TB-Profiler result

Run: SRR14066533
Summary

Run ID: SRR14066533

Sample name:

Date: 2024-10-04T18:10:19.268675

Number of reads: 7371796

Percentage reads mapped: 77.84

Median coverage: 213.0

Strain: lineage1.1.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.1 Indo-Oceanic RD239 0.98
lineage1 Indo-Oceanic RD239 0.93
lineage1.1.1 Indo-Oceanic RD239 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 756 c.756T>C synonymous_variant 0.17 isoniazid
dnaA 765 c.765G>A synonymous_variant 0.18 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.17 isoniazid
dnaA 783 c.783C>T synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 795 c.795A>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 798 c.798C>T synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.18 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.19 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.18 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 840 c.840G>A synonymous_variant 0.17 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.16 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 885 c.885T>C synonymous_variant 0.16 isoniazid
dnaA 894 c.894G>A synonymous_variant 0.15 isoniazid
gyrB 6112 p.Met291Ile missense_variant 0.93 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6160 c.921C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6169 c.930C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6181 c.942C>A synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6184 c.945C>A synonymous_variant 0.2 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6208 c.969G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6280 c.1041T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6586 c.-716T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6652 c.-650C>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6766 c.-536G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6769 c.-533C>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6772 c.1533C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6794 p.Ile519Leu missense_variant 0.27 levofloxacin
moxifloxacin
gyrB 6797 p.Gly520Ser missense_variant 0.27 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6847 c.-455C>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6898 c.-404G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6926 c.1687T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6931 c.1692A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6950 c.-352_-350delCTCinsTTG upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6970 p.Asp577Glu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7012 c.1773G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7018 c.-284G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7024 c.-278G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7069 c.-233C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7114 c.-188C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 7126 c.1887G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7129 c.-173T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7162 c.-140C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7457 c.156T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7496 c.195C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7532 c.231T>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7787 c.486G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7796 c.495G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8438 c.1137C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8452 p.Ala384Val missense_variant 0.8 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8459 c.1158G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8537 c.1236G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8555 c.1254G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8573 c.1272G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8628 c.1327C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8767 p.Arg489Lys missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8786 c.1485T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8983 p.Cys561Ser missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9252 p.Val651Ile missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9263 c.1962C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9268 p.Asn656Thr missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9300 p.Ala667Ser missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9326 c.2025G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
Rv0010c 13275 p.Tyr95Cys missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
fgd1 490854 c.72C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491229 c.447C>T synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491265 c.483G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491286 c.504G>A synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491296 p.Val172Ile missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491328 c.546C>A synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491340 c.558C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491343 c.561C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491355 c.573C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491364 c.582T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491367 c.585G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491388 c.606C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491393 p.Thr204Asn missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491472 c.690A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 574679 c.-669C>T upstream_gene_variant 0.16 isoniazid Uncertain significance
ethionamide Uncertain significance
mshA 574683 c.-665T>C upstream_gene_variant 0.16 isoniazid Uncertain significance
ethionamide
mshA 574694 c.-654C>G upstream_gene_variant 0.16 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.17 isoniazid
ethionamide
mshA 575725 c.378C>G synonymous_variant 0.16 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575743 c.396C>T synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575773 c.426C>A synonymous_variant 0.15 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.16 isoniazid
ethionamide
mshA 575806 c.459G>C synonymous_variant 0.16 isoniazid
ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657690 c.-220C>A upstream_gene_variant 0.15 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.19 ethionamide
nusG 734116 c.-138T>C upstream_gene_variant 0.98 rifampicin Not assoc w R
nusG 734439 c.186C>G synonymous_variant 0.17 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.19 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.2 rifampicin
nusG 734469 c.216C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.22 rifampicin
nusG 734508 c.255C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734790 c.537G>C synonymous_variant 0.17 rifampicin
nusG 734814 c.561G>C synonymous_variant 0.18 rifampicin
nusG 734817 c.564C>G synonymous_variant 0.18 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.19 rifampicin
mmaA3 737874 c.276C>T synonymous_variant 0.15 isoniazid
rpoB 760124 c.318C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760139 c.333A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.18 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.22 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.24 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.22 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.22 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.22 rifampicin
rpoB 760331 c.525G>T synonymous_variant 0.21 rifampicin
rpoB 760337 c.531C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760340 c.534G>C synonymous_variant 0.18 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760564 p.Arg253Leu missense_variant 0.15 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.17 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760637 c.831G>A synonymous_variant 0.15 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.17 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760971 c.1165C>A synonymous_variant 0.22 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.26 rifampicin
rpoB 761006 c.1200C>T synonymous_variant 0.27 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.25 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.24 rifampicin
rpoB 761126 c.1320G>C synonymous_variant 0.23 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.2 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761375 c.1569G>C synonymous_variant 0.17 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.2 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.18 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.17 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.17 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.17 rifampicin
rpoB 761453 c.1647C>G synonymous_variant 0.17 rifampicin
rpoB 761457 p.Pro551Gly missense_variant 0.17 rifampicin
rpoB 761465 c.1659G>C synonymous_variant 0.2 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.2 rifampicin
rpoB 761507 c.1701G>T synonymous_variant 0.21 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.2 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.23 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.21 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.16 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.18 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.19 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.17 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.18 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.18 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.19 rifampicin
rpoB 761819 c.2013G>C synonymous_variant 0.18 rifampicin
rpoB 761834 c.2028T>G synonymous_variant 0.2 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.19 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.19 rifampicin
rpoB 761867 c.2061C>T synonymous_variant 0.22 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.21 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.22 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.22 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.22 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.21 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.22 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.22 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.25 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.22 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.22 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.22 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.21 rifampicin
rpoB 762149 c.2343G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762161 c.2355C>G synonymous_variant 0.2 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.27 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.26 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.26 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.19 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.2 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.2 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.2 rifampicin
rpoC 762389 c.-981G>A upstream_gene_variant 0.2 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.18 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.18 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.18 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.19 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762446 c.-924C>G upstream_gene_variant 0.19 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762486 p.Pro894Ala missense_variant 0.16 rifampicin
rpoB 762490 p.Val895Asp missense_variant 0.16 rifampicin
rpoC 762518 c.-852C>T upstream_gene_variant 0.17 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.18 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.17 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 0.18 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.17 rifampicin
rpoC 762728 c.-642C>G upstream_gene_variant 0.16 rifampicin
rpoC 762749 c.-621C>G upstream_gene_variant 0.18 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762759 p.Cys985Ala missense_variant 0.18 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.19 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.19 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.21 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762868 p.Tyr1021Phe missense_variant 0.26 rifampicin
rpoC 762890 c.-480C>T upstream_gene_variant 0.27 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.25 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.25 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.21 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.17 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.23 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.25 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.27 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.26 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.25 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.25 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.23 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.25 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.25 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.23 rifampicin
rpoC 763851 p.Ala161Gly missense_variant 0.23 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.24 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.24 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.25 rifampicin
rpoC 763876 c.507A>G synonymous_variant 0.25 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.26 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.74 rifampicin Not assoc w R
rpoC 763886 c.517C>A synonymous_variant 0.73 rifampicin Not assoc w R
rpoC 763894 c.525A>G synonymous_variant 0.27 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.27 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.28 rifampicin
rpoC 763948 c.579G>C synonymous_variant 0.28 rifampicin
rpoC 763963 c.594C>G synonymous_variant 0.28 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.26 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.26 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.27 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.26 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.25 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.26 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.26 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764099 p.Leu244Ile missense_variant 0.24 rifampicin
rpoC 764110 c.741C>G synonymous_variant 0.27 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.26 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.3 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.3 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.29 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.27 rifampicin
rpoC 764248 c.879C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764255 c.886C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764266 c.897T>C synonymous_variant 0.24 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.24 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.24 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764326 c.957G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.21 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764381 p.Ser338Thr missense_variant 0.17 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.21 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.21 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.22 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764479 c.1110G>A synonymous_variant 0.23 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.21 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>G synonymous_variant 0.22 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.23 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.23 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.2 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.2 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.21 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.24 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.24 rifampicin
rpoC 764896 c.1527C>T synonymous_variant 0.24 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.24 rifampicin
rpoC 764929 c.1560G>A synonymous_variant 0.23 rifampicin
rpoC 764932 c.1563C>G synonymous_variant 0.22 rifampicin
rpoC 764939 c.1570C>T synonymous_variant 0.22 rifampicin
rpoC 764962 c.1593G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>G synonymous_variant 0.21 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.2 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765171 p.Pro601Leu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765403 c.2034G>C synonymous_variant 0.18 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.18 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.18 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.18 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765533 p.Tyr722His missense_variant 0.21 rifampicin Uncertain significance
rpoC 765541 c.2172C>G synonymous_variant 0.2 rifampicin
rpoC 765547 c.2178C>A synonymous_variant 0.2 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.21 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.21 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.21 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.22 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765694 c.2325G>C synonymous_variant 0.2 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765724 c.2355C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365_2367delTTGinsCTC synonymous_variant 0.2 rifampicin
rpoC 765739 c.2370G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765753 p.Asp795Ala missense_variant 0.21 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.2 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.21 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.21 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.2 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.2 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.23 rifampicin
rpoC 765883 c.2514C>G synonymous_variant 0.24 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.24 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.21 rifampicin
rpoC 765986 c.2617C>T synonymous_variant 0.21 rifampicin
rpoC 765997 c.2628T>C synonymous_variant 0.22 rifampicin
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.2 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.2 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.21 rifampicin
rpoC 766057 c.2688C>A synonymous_variant 0.19 rifampicin
rpoC 766083 p.Ala905Glu missense_variant 0.15 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.19 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.2 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.2 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766393 c.3024C>G synonymous_variant 0.23 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.26 rifampicin
rpoC 766444 c.3075C>G synonymous_variant 0.28 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.27 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.28 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.27 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.27 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.26 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.26 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.25 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.25 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.24 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.24 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.24 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.23 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.23 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.23 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.21 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.23 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.23 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.22 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.22 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.21 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.2 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.19 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.18 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.18 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.21 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.23 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.23 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.23 rifampicin
rpoC 766907 c.3538C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.22 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.23 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.22 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>A synonymous_variant 0.21 rifampicin
rpoC 767032 c.3663G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>T synonymous_variant 0.23 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.26 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767113 c.3744G>C synonymous_variant 0.26 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.24 rifampicin
rpoC 767149 c.3780C>G synonymous_variant 0.22 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.19 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.17 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.17 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.21 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.2 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.19 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.19 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.19 streptomycin
rpsL 781742 c.183C>G synonymous_variant 0.19 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.18 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.18 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.19 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.2 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.2 streptomycin
rpsL 781817 c.258G>A synonymous_variant 0.19 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.19 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.2 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.18 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.18 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.21 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.21 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.21 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.25 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.26 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.27 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.27 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.28 streptomycin
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
rplC 800537 c.-272C>T upstream_gene_variant 0.14 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.18 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.19 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.2 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.2 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.17 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.17 linezolid
rplC 800708 c.-101C>T upstream_gene_variant 0.16 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.16 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.17 linezolid
rplC 801210 c.402T>G synonymous_variant 0.17 linezolid Not assoc w R - Interim
rplC 801249 c.441T>G synonymous_variant 0.18 linezolid
rplC 801267 c.459A>C synonymous_variant 0.18 linezolid
rplC 801270 c.462T>C synonymous_variant 0.18 linezolid
rplC 801276 c.468G>C synonymous_variant 0.18 linezolid
rplC 801309 c.501C>T synonymous_variant 0.18 linezolid
rplC 801312 c.504G>C synonymous_variant 0.18 linezolid
rplC 801324 c.516T>C synonymous_variant 0.16 linezolid
Rv1129c 1254543 c.-9T>G upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303509 c.579G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303512 c.582T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303581 c.651G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303584 c.654C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303590 c.660A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>T synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303788 c.858T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303794 c.864A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303848 c.918C>T synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303869 c.939T>C synonymous_variant 0.19 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303884 c.954T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303890 c.960G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303908 c.978C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303935 c.1005G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303961 p.Arg344Leu missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303969 p.Val347Ile missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303980 c.1050G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304904 c.1974G>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304911 c.1981C>T synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304925 c.1995G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304940 c.2010A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304970 c.2040G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305075 c.2145T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305078 c.2148A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1305096 c.2166T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305099 c.2169T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305126 c.2196T>C synonymous_variant 0.17 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1305150 c.2220C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305153 c.2223G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1305173 p.Asn748Ser missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305177 c.2247A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305198 c.2268G>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1305204 c.2274C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305215 p.Ser762Thr missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305219 c.2289T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
sigE 1364691 c.279T>C synonymous_variant 0.16 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.17 pyrazinamide
sigE 1364715 c.303G>C synonymous_variant 0.19 pyrazinamide
sigE 1364733 p.His107Gln missense_variant 0.19 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.22 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.23 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.22 pyrazinamide
sigE 1364772 c.360G>C synonymous_variant 0.21 pyrazinamide
sigE 1364778 c.366G>C synonymous_variant 0.22 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.22 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.2 pyrazinamide
sigE 1364802 c.390C>G synonymous_variant 0.2 pyrazinamide
sigE 1364805 c.393C>G synonymous_variant 0.21 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.22 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.21 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.19 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.18 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.18 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.17 pyrazinamide
sigE 1364868 c.456T>C synonymous_variant 0.17 pyrazinamide
sigE 1364877 c.465G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.19 pyrazinamide
sigE 1364898 c.486C>T synonymous_variant 0.2 pyrazinamide
sigE 1364913 c.501C>G synonymous_variant 0.22 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.23 pyrazinamide
sigE 1364943 c.531C>T synonymous_variant 0.22 pyrazinamide
sigE 1364949 c.537C>T synonymous_variant 0.21 pyrazinamide
sigE 1364950 p.Ala180Ser missense_variant 0.2 pyrazinamide
sigE 1364961 c.549A>G synonymous_variant 0.2 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.19 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.2 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.2 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.21 pyrazinamide
sigE 1365015 c.603G>C synonymous_variant 0.19 pyrazinamide
sigE 1365018 c.606G>C synonymous_variant 0.19 pyrazinamide
sigE 1365037 c.625C>T synonymous_variant 0.17 pyrazinamide
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
atpE 1461227 c.183G>A synonymous_variant 1.0 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473290 n.1445delCinsTT non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474018 n.361G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474040 n.383G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1052G>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475220 n.1563G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475297 n.1640C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475366 n.1709G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475401 n.1745delC non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475617 n.1960C>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475625 n.1968G>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475655 n.1998T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475758 n.2104delC non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475883 n.2226A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476711 n.3054G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476719 n.3062C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
inhA 1673808 c.-394A>G upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673870 c.-332G>T upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1673898 c.-304C>T upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673901 c.-301A>G upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673905 c.-297T>G upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673916 c.-286A>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673917 c.-285G>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1674006 c.-196T>G upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674024 c.-178T>C upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674336 c.135G>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674342 c.141T>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674348 c.147C>G synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674352 p.Thr51Ala missense_variant 0.21 isoniazid
ethionamide Uncertain significance
inhA 1674368 p.Ala56Glu missense_variant 0.16 isoniazid
ethionamide
inhA 1674375 c.174C>G synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674382 p.Leu61Ile missense_variant 0.19 isoniazid
ethionamide
inhA 1674419 p.Ser73Thr missense_variant 0.22 isoniazid
ethionamide
inhA 1674421 c.220T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674428 p.Gly76Glu missense_variant 0.22 isoniazid
ethionamide
inhA 1674440 p.Glu80Ala missense_variant 0.21 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1674443 p.Ala81Glu missense_variant 0.21 isoniazid
ethionamide
inhA 1674450 c.249G>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674455 p.Gly85Asp missense_variant 0.23 isoniazid
ethionamide
inhA 1674465 c.264C>G synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674471 c.270G>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674480 c.279T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674486 c.285T>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674489 c.288G>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674537 c.336C>A synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.18 isoniazid
ethionamide
inhA 1674552 c.351C>G synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674573 c.372G>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674575 p.Tyr125Phe missense_variant 0.21 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.22 isoniazid
ethionamide
inhA 1674624 c.423A>T synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674627 c.426T>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674651 c.450C>T synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674655 c.454_456delAGCinsTCG synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674660 c.459G>T synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674690 c.489C>G synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674738 c.537C>G synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674741 c.540C>T synonymous_variant 0.22 isoniazid Not assoc w R - Interim
ethionamide
inhA 1674742 p.Lys181Pro missense_variant 0.23 isoniazid
ethionamide
inhA 1674750 c.549T>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674756 c.555T>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674771 c.570C>G synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.3 isoniazid
ethionamide
inhA 1674816 c.615T>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674846 p.Ile215Met missense_variant 0.24 isoniazid
ethionamide
inhA 1674870 c.669T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674879 c.678T>G synonymous_variant 0.19 isoniazid
ethionamide
rpsA 1833595 c.54T>G synonymous_variant 0.17 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.16 pyrazinamide
rpsA 1833610 c.69C>T synonymous_variant 0.16 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833928 c.387G>A synonymous_variant 0.26 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.16 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834144 c.603G>A synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834177 c.636A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.22 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834319 p.Val260Ile missense_variant 0.79 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>G synonymous_variant 0.27 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834459 c.918G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834633 c.1092A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834751 p.Leu404Ile missense_variant 0.16 pyrazinamide
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.21 linezolid
tsnR 1853375 c.-231G>C upstream_gene_variant 0.22 linezolid
tsnR 1853387 c.-219T>C upstream_gene_variant 0.23 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.21 linezolid
tsnR 1853411 c.-195C>T upstream_gene_variant 0.23 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.25 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.23 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.23 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.18 linezolid
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tsnR 1854045 p.Tyr147Cys missense_variant 1.0 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
bacA 2063106 c.1623G>A synonymous_variant 1.0 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ndh 2102305 c.738T>C synonymous_variant 0.17 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2156681 c.-570C>A upstream_gene_variant 1.0 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2167983 p.Gly877Asp missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.16 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.19 isoniazid
kasA 2518245 p.His44Arg missense_variant 0.21 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.22 isoniazid
kasA 2518255 c.141A>G synonymous_variant 0.21 isoniazid
kasA 2518273 c.159G>A synonymous_variant 0.21 isoniazid
kasA 2518279 c.165T>C synonymous_variant 0.19 isoniazid
kasA 2518280 c.166C>T synonymous_variant 0.18 isoniazid
kasA 2518283 p.Ala57Pro missense_variant 0.18 isoniazid
kasA 2518297 c.183C>T synonymous_variant 0.2 isoniazid
kasA 2518300 c.186T>A synonymous_variant 0.2 isoniazid
kasA 2518312 p.Asp66Glu missense_variant 0.19 isoniazid
kasA 2518315 c.201G>C synonymous_variant 0.18 isoniazid
kasA 2518321 c.207C>T synonymous_variant 0.17 isoniazid
kasA 2518323 p.Ser70Asn missense_variant 0.17 isoniazid
kasA 2518334 c.220C>A synonymous_variant 0.16 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.19 isoniazid
kasA 2518567 c.453G>T synonymous_variant 0.19 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.21 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.21 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.22 isoniazid
kasA 2518603 c.489G>C synonymous_variant 0.22 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.21 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.21 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.24 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.22 isoniazid
kasA 2518708 c.594C>G synonymous_variant 0.23 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.23 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.24 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.25 isoniazid
kasA 2518756 c.642G>T synonymous_variant 0.27 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.25 isoniazid
kasA 2518789 c.675G>T synonymous_variant 0.26 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.26 isoniazid
kasA 2518798 c.684G>T synonymous_variant 0.26 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.25 isoniazid
kasA 2518837 c.723G>A synonymous_variant 0.23 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.22 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.19 isoniazid
kasA 2518867 c.753G>A synonymous_variant 0.18 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 0.99 isoniazid
ahpC 2726070 c.-123G>A upstream_gene_variant 1.0 isoniazid
folC 2746351 c.1248C>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2746360 c.1239T>C synonymous_variant 0.16 para-aminosalicylic_acid
folC 2746378 c.1221G>T synonymous_variant 0.16 para-aminosalicylic_acid
folC 2746381 c.1218C>T synonymous_variant 0.15 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747412 p.Ser63Gly missense_variant 0.19 para-aminosalicylic_acid
folC 2747414 p.Arg62Leu missense_variant 0.2 para-aminosalicylic_acid
folC 2747419 c.180C>G synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747422 c.177G>C synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747425 c.174C>G synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747442 c.157T>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747443 c.156G>C synonymous_variant 0.19 para-aminosalicylic_acid
Rv2477c 2783008 c.1035C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783015 p.Ser343Thr missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.17 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>T synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783071 c.972C>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783083 c.960G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783119 c.924G>A synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.28 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.28 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.28 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783185 c.858G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783218 c.825C>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>A synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783287 c.756C>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783317 c.726G>A synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783407 c.636C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783419 c.624G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783432 p.Ser204Ala missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.25 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783509 c.534C>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783557 c.486T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783566 c.477C>T synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783578 c.465G>A synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783602 c.441G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783626 p.Ala139Ser missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783632 c.411C>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783788 c.255T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783791 c.252C>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3064632 c.1560C>T synonymous_variant 0.97 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
Rv2752c 3065457 c.735A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065463 c.729T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065487 c.705T>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065490 c.702A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065493 c.699G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065496 c.696G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065499 c.693A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065508 c.684T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065511 c.681G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065517 c.675C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065528 c.664C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065532 c.660A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065538 c.654G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065550 c.642G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065553 c.639A>G synonymous_variant 0.19 levofloxacin
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065576 p.Ala206Ser missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065577 c.615C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065580 c.612G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065595 p.Leu199Phe missense_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065610 p.Thr194Ala missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065619 c.573C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065634 c.558G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065637 c.555A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065640 c.552T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065649 c.543T>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065652 c.540C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065659 p.Pro178Leu missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3066141 c.51G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066156 c.36C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066171 c.21G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066176 p.Pro6Thr missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066195 c.-4A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066231 c.-40G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066483 c.-292T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066930 c.-739G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066934 c.-743G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066966 c.-775C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066969 c.-778G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066981 c.-790T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066994 c.-804_-803delCAinsGG upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3067011 c.-820C>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067244 c.702C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067249 p.Thr233Ser missense_variant 0.17 para-aminosalicylic_acid
thyX 3067271 c.675G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067274 c.672C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067277 c.669C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067284 p.Ala221Gly missense_variant 0.2 para-aminosalicylic_acid
thyX 3067287 p.Ala220Val missense_variant 0.2 para-aminosalicylic_acid
thyX 3067304 c.642A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067316 c.630A>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067355 c.591A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067430 c.516C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067466 c.480G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067470 p.Asn159Ser missense_variant 0.18 para-aminosalicylic_acid
thyX 3067472 c.474C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073968 c.504C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.18 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
lpqB 3624008 c.903T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624014 c.897T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624037 c.874A>C synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624041 p.Glu290Asp missense_variant 0.21 rifampicin
bedaquiline
lpqB 3624050 c.861C>G synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624077 c.834G>C synonymous_variant 0.23 rifampicin
bedaquiline
lpqB 3624082 c.829A>C synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624089 c.822C>G synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624094 c.817A>C synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624100 c.811T>C synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624101 c.810C>G synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624107 c.804C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624116 c.795A>G synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624125 c.786A>G synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624486 p.Asp142Gly missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3624701 c.210T>G synonymous_variant 0.16 rifampicin
bedaquiline
lpqB 3624722 c.189C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624731 c.180C>G synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624749 c.162G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624760 c.151C>T synonymous_variant 0.15 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625095 p.Glu507Gln missense_variant 0.16 rifampicin
bedaquiline
lpqB 3625117 c.-207T>G upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625123 c.-213T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625134 c.-224T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625135 c.-225A>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625138 c.-228C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625141 c.-231T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625161 c.-251T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3625162 c.1452T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625183 c.-273G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625186 c.-276T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625189 c.1425A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625195 c.-285A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625198 c.-288C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625201 c.-291T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625222 c.1392T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625240 c.-330T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625243 c.-333T>G upstream_gene_variant 0.22 rifampicin
bedaquiline
lpqB 3625255 c.-345T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625258 c.-348G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625267 c.1347T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625270 c.-360G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625276 c.-366C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625285 c.-375G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625537 c.-627T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625543 c.-633G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625569 c.1045T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625585 c.-675G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3625592 p.Ser341Asn missense_variant 0.25 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3625615 p.Arg333Ala missense_variant 0.26 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625675 c.-765G>C upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.25 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 c.852A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625801 c.-891G>T upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625840 c.-930A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626400 p.Ile72Val missense_variant 0.17 rifampicin
bedaquiline
mtrB 3626404 c.210C>G synonymous_variant 0.18 rifampicin
bedaquiline
mtrB 3626407 c.207C>G synonymous_variant 0.18 rifampicin
bedaquiline
mtrB 3626410 c.204T>C synonymous_variant 0.17 rifampicin
bedaquiline
mtrB 3626413 c.201T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626437 c.177T>C synonymous_variant 0.17 rifampicin
bedaquiline
mtrA 3626723 c.627C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3626729 c.-116G>A upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626780 c.-167T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626852 c.-239G>A upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626857 c.-244T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626888 c.-277_-275delTTGinsCTC upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626891 c.-278G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3626939 p.Glu137Asp missense_variant 0.25 rifampicin
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626954 c.-341C>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626999 c.-386G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627011 c.-398T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627071 c.-458G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627110 c.-497G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627116 c.-503G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627139 c.-526T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3627170 c.-557C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3627187 c.163T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627188 c.-577_-575delTTAinsCTG upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627197 c.-584T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627221 c.-608C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
rpoA 3877587 c.921A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.2 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877677 p.Ala277Thr missense_variant 0.16 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.22 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.22 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>C synonymous_variant 0.23 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.2 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.21 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.19 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.19 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.25 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.22 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.22 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.22 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.22 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.2 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.22 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.21 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.21 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.18 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.18 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.18 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.18 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.18 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.18 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.22 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.24 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.24 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878256 c.252G>C synonymous_variant 0.26 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.25 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.23 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.23 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878364 c.144A>C synonymous_variant 0.27 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.29 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.27 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.23 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.22 rifampicin
rpoA 3878432 c.76C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878436 c.72A>G synonymous_variant 0.22 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.22 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.21 rifampicin
rpoA 3878458 p.Asn17Thr missense_variant 0.2 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.16 rifampicin
rpoA 3878630 c.-124delC upstream_gene_variant 0.99 rifampicin Not assoc w R
rpoA 3878725 c.-218A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.19 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.19 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878749 c.-242G>C upstream_gene_variant 0.19 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.25 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878806 c.-299C>A upstream_gene_variant 0.24 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.23 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.22 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878889 c.-382A>G upstream_gene_variant 0.19 rifampicin
rpoA 3878890 c.-383C>G upstream_gene_variant 0.19 rifampicin
rpoA 3878893 c.-388_-386delCACinsAAG upstream_gene_variant 0.19 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878917 c.-410G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878926 c.-419C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.16 rifampicin
rpoA 3878947 c.-440G>A upstream_gene_variant 0.18 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.18 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878995 c.-488A>G upstream_gene_variant 0.17 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.19 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.26 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.27 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879130 c.-623A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.17 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.18 pretomanid
delamanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.17 pretomanid
delamanid
ddn 3986660 c.-184C>T upstream_gene_variant 0.15 pretomanid
delamanid
ddn 3987083 c.240C>T synonymous_variant 0.15 pretomanid
delamanid
ddn 3987086 c.243C>T synonymous_variant 0.15 pretomanid
delamanid
clpC1 4038640 p.Asp689Asn missense_variant 0.16 pyrazinamide
clpC1 4038644 p.Glu687Asp missense_variant 0.17 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.15 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038674 c.2031C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038721 c.1984C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038848 c.1857C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038860 c.1845G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038884 c.1821C>T synonymous_variant 0.25 pyrazinamide
clpC1 4038899 c.1806C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.26 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039094 c.1611C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039139 p.Glu522Val missense_variant 0.18 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039162 p.His515Tyr missense_variant 0.79 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.19 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.19 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039258 p.Gln483Glu missense_variant 0.19 pyrazinamide
clpC1 4039259 p.Glu482Asn missense_variant 0.19 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039286 p.Leu473Met missense_variant 0.22 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.25 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.22 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.21 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039406 c.1299G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039412 c.1293T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.23 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Ser missense_variant 0.24 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039581 p.Thr375Ser missense_variant 0.23 pyrazinamide
clpC1 4039601 c.1104G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039621 c.1084C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039622 c.1083C>A synonymous_variant 0.22 pyrazinamide
clpC1 4039646 p.Glu353Ala missense_variant 0.2 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039790 c.915C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.16 pyrazinamide
clpC1 4040517 p.Val63Ala missense_variant 0.91 pyrazinamide Not assoc w R - Interim
glpK 4138338 p.Ala473Asp missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138360 c.1396T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138361 c.1395C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138376 p.Val460Ala missense_variant 0.18 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4138379 c.1377T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138382 c.1374A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138385 c.1371A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138391 c.1365C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138418 c.1338T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138429 c.1327T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138451 c.1305T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138463 c.1293C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138472 c.1284G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138478 c.1278T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138634 c.1122G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138643 c.1113A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138646 c.1110G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138654 c.1102C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138661 c.1095T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138670 c.1086G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138681 p.Met359Val missense_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138697 c.1059C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138703 c.1053C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138714 p.Ala348Ser missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.997_999delCTAinsTTG synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138796 c.960A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138799 c.957T>A synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138808 c.948G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139265 p.Ala164Glu missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139315 c.441C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240726 c.864G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embC 4240765 c.903C>G synonymous_variant 0.25 ethambutol
embC 4240771 c.909G>C synonymous_variant 0.25 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.25 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.25 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.26 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.25 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.26 ethambutol
embC 4240859 p.Leu333Val missense_variant 0.26 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.24 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.24 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.23 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.23 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.22 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.23 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.23 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.21 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.21 ethambutol
embC 4240935 p.Val358Ala missense_variant 0.19 ethambutol Uncertain significance
embC 4240945 c.1083T>C synonymous_variant 0.21 ethambutol
embC 4240948 c.1086G>A synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4240951 c.1089C>G synonymous_variant 0.2 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.21 ethambutol
embC 4240963 c.1101G>C synonymous_variant 0.22 ethambutol
embC 4240966 c.1104G>C synonymous_variant 0.22 ethambutol
embC 4240978 c.1116G>A synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embC 4240983 p.Ser374Asn missense_variant 0.22 ethambutol
embC 4240990 c.1128A>C synonymous_variant 0.22 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.22 ethambutol
embC 4241020 c.1158G>C synonymous_variant 0.22 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.22 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.26 ethambutol
embC 4241042 p.Asn394Asp missense_variant 0.74 ethambutol Not assoc w R
embC 4241050 c.1188T>G synonymous_variant 0.26 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.26 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.26 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.27 ethambutol
embC 4241101 c.1239G>C synonymous_variant 0.25 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.26 ethambutol
embC 4241140 c.1278A>C synonymous_variant 0.23 ethambutol
embC 4241158 c.1296T>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4241161 c.1299C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.2 ethambutol
embC 4241179 c.1317G>A synonymous_variant 0.2 ethambutol
embC 4241185 c.1323G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241203 c.1341T>C synonymous_variant 0.17 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.99 ethambutol Not assoc w R
embA 4242847 c.-386C>A upstream_gene_variant 0.15 ethambutol
embA 4243848 p.Val206Met missense_variant 1.0 ethambutol Not assoc w R
embA 4244096 c.864C>T synonymous_variant 0.99 ethambutol Not assoc w R
embA 4244933 c.1701A>G synonymous_variant 0.18 ethambutol
embA 4244936 c.1704C>G synonymous_variant 0.18 ethambutol
embA 4244960 c.1728A>G synonymous_variant 0.2 ethambutol
embA 4244978 c.1746G>C synonymous_variant 0.2 ethambutol
embA 4244980 p.Val583Ala missense_variant 0.2 ethambutol
embA 4244982 c.1750T>C synonymous_variant 0.21 ethambutol
embA 4244987 c.1755T>C synonymous_variant 0.22 ethambutol
embA 4245003 p.Thr591Ala missense_variant 0.23 ethambutol Uncertain significance
embA 4245008 c.1776T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embA 4245014 c.1782C>G synonymous_variant 0.24 ethambutol
embA 4245023 c.1791A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embA 4245026 c.1794T>C synonymous_variant 0.23 ethambutol
embA 4245029 c.1797T>C synonymous_variant 0.23 ethambutol
embA 4245032 c.1800A>C synonymous_variant 0.23 ethambutol
embA 4245041 c.1809C>G synonymous_variant 0.25 ethambutol
embA 4245053 c.1821G>C synonymous_variant 0.25 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.24 ethambutol
embA 4245083 c.1851A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embA 4245101 c.1869G>C synonymous_variant 0.17 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.17 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.17 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.17 ethambutol
embA 4245183 c.1951C>T synonymous_variant 0.16 ethambutol
embA 4245355 p.Ala708Gly missense_variant 0.17 ethambutol
embA 4245359 c.2127G>C synonymous_variant 0.17 ethambutol
embA 4245362 c.2130G>C synonymous_variant 0.17 ethambutol
embA 4245368 c.2136T>C synonymous_variant 0.17 ethambutol
embA 4245969 p.Pro913Ser missense_variant 0.99 ethambutol Not assoc w R
embB 4247470 c.957T>C synonymous_variant 0.18 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.17 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.17 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.18 ethambutol
embB 4247550 p.Ala346Asp missense_variant 0.15 ethambutol
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248052 c.1539G>T synonymous_variant 0.16 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.19 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.19 ethambutol
embB 4248098 p.Ile529Phe missense_variant 0.19 ethambutol
embB 4248109 c.1596C>G synonymous_variant 0.22 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.22 ethambutol
embB 4248119 p.Ser536Ala missense_variant 0.23 ethambutol
embB 4248122 p.Leu537Val missense_variant 0.24 ethambutol
embB 4248133 c.1620C>A synonymous_variant 0.23 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.21 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.21 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.22 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.21 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.2 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4249369 c.2856T>C synonymous_variant 0.16 ethambutol
embB 4249378 c.2865G>A synonymous_variant 0.15 ethambutol
ubiA 4269077 p.Ile253Val missense_variant 0.16 ethambutol
ubiA 4269164 p.Leu224Met missense_variant 0.16 ethambutol
ubiA 4269173 p.Val221Ile missense_variant 0.16 ethambutol
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4327483 c.-10G>A upstream_gene_variant 1.0 ethionamide Uncertain significance
whiB6 4338242 p.Gln94Glu missense_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 1.0 streptomycin Not assoc w R