TB-Profiler result

Run: SRR9971041
Summary

Run ID: SRR9971041

Sample name:

Date: 2024-10-04T23:51:07.361242

Number of reads: 3021270

Percentage reads mapped: 60.99

Median coverage: 86.0

Strain: lineage4.3.3

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4 Euro-American None 1.0
lineage4.3.3 Euro-American (LAM) RD115 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ahpC c.-52C>T Uncertain significance Mutation from literature
ethambutol embB p.Met306Ile Assoc w R
p.Gly406Ala Assoc w R
pyrazinamide pncA c.377_*115del Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
rrs n.799C>T Uncertain significance Mutation from literature
gid c.160_290del Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide ethA c.-11A>G Uncertain significance Mutation from literature
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.9 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.8 streptomycin Assoc w R
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.32 amikacin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.28 amikacin Assoc w R
capreomycin Assoc w R
kanamycin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2288565 c.377_*115del frameshift_variant&stop_lost&splice_region_variant 1.0 pyrazinamide Assoc w R
ahpC 2726141 c.-52C>T upstream_gene_variant 1.0 isoniazid Uncertain significance Mutation from literature
embB 4247431 p.Met306Ile missense_variant 0.87 ethambutol Assoc w R
embB 4247730 p.Gly406Ala missense_variant 1.0 ethambutol Assoc w R
ethA 4327484 c.-11A>G upstream_gene_variant 1.0 ethionamide Uncertain significance Mutation from literature
gid 4407912 c.160_290del frameshift_variant 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6769 c.-533C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7108 c.-194G>A upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7397 c.96G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7433 c.132G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7847 c.546G>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8040 p.Gly247Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8513 c.1212C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8535 p.Glu412Gln missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8549 c.1248C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9324 c.2023_2025delTCGinsAGC synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9345 c.2044_2046delAGGinsCGC synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9353 c.2052G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9407 c.2106C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 491499 c.717G>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491508 c.726A>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491512 p.Asn244Asp missense_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491536 c.754C>T synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>T synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491548 p.Ala256Pro missense_variant 0.14 pretomanid
delamanid
clofazimine
fgd1 491571 c.789C>T synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491595 c.813C>T synonymous_variant 0.14 pretomanid
delamanid
clofazimine
mshA 575749 c.402C>A synonymous_variant 0.13 isoniazid
ethionamide
mshA 575764 c.417C>G synonymous_variant 0.17 isoniazid
ethionamide
mshA 575771 p.Val142Thr missense_variant 0.16 isoniazid
ethionamide
mshA 575776 c.429C>T synonymous_variant 0.17 isoniazid
ethionamide
mshA 575782 c.435G>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575795 p.Ile150Val missense_variant 0.17 isoniazid
ethionamide
mshA 575800 c.453G>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575803 c.456C>T synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.19 isoniazid
ethionamide
mshA 575842 c.495G>C synonymous_variant 0.15 isoniazid
ethionamide
ccsA 620661 c.771C>G synonymous_variant 0.13 kanamycin
capreomycin
amikacin
ccsA 620694 c.804C>G synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620698 p.Val270Ile missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620715 c.825C>T synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620730 c.840C>T synonymous_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620742 c.852G>C synonymous_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>C synonymous_variant 0.14 kanamycin
capreomycin
amikacin
rpoB 759940 p.Pro45Leu missense_variant 0.97 rifampicin Uncertain significance
rpoB 760235 c.429T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.17 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.17 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.2 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.2 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.18 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760406 c.600G>T synonymous_variant 0.19 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.2 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.19 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.17 rifampicin Uncertain significance
rpoB 760748 c.942C>G synonymous_variant 0.15 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.15 rifampicin
rpoB 760755 p.His317Asn missense_variant 0.15 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.16 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.15 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.16 rifampicin
rpoB 760784 c.978G>T synonymous_variant 0.16 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.18 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.18 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.17 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.14 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.15 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 0.17 rifampicin
rpoB 761217 p.Pro471Ser missense_variant 0.15 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.23 rifampicin
rpoB 761288 c.1482G>T synonymous_variant 0.23 rifampicin
rpoB 761318 c.1512G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.23 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 0.22 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.19 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.16 rifampicin
rpoB 761367 p.Glu521Gln missense_variant 0.16 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.16 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.13 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.16 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.19 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.19 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.19 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.29 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762308 c.2502G>C synonymous_variant 0.29 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.28 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.29 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.28 rifampicin
rpoB 762350 c.2544C>T synonymous_variant 0.27 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.28 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.27 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.26 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.23 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.22 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.22 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.24 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.2 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.2 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.21 rifampicin Uncertain significance
rpoB 762920 c.3114C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.25 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.15 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.21 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.22 rifampicin
rpoC 763190 c.-180C>T upstream_gene_variant 0.16 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.13 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>T synonymous_variant 0.21 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763600 c.231C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.19 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.22 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.21 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.2 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.16 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.16 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.15 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.15 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763872 p.Gly168Ala missense_variant 0.13 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.16 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.17 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.15 rifampicin Uncertain significance
rpoC 764195 c.826_828delTCGinsAGC synonymous_variant 0.16 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.17 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.18 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.18 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.18 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.18 rifampicin
rpoC 764227 c.858G>T synonymous_variant 0.16 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 0.22 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.22 rifampicin
rpoC 764263 c.894G>T synonymous_variant 0.21 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.22 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.21 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.25 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.39 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.21 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.22 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.22 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.21 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.22 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.18 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.26 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>G synonymous_variant 0.16 rifampicin
rpoC 764548 c.1179G>A synonymous_variant 0.16 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.15 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.14 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.14 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764707 c.1338G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.26 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.21 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.21 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.19 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.19 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.25 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.86 rifampicin Not assoc w R
rpoC 765445 c.2076G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.17 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.19 rifampicin Uncertain significance
rpoC 765496 c.2127C>G synonymous_variant 0.2 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.15 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.14 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.15 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.14 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.15 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.14 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.14 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.14 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767105 p.Asn1246Gln missense_variant 0.16 rifampicin Uncertain significance
rpoC 767119 c.3750A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.24 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.27 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.27 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.23 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.19 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.18 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775856 c.2625T>C synonymous_variant 0.15 bedaquiline
clofazimine
mmpL5 775892 c.2589C>T synonymous_variant 0.16 bedaquiline
clofazimine
mmpL5 775904 c.2577G>A synonymous_variant 0.2 bedaquiline
clofazimine
mmpL5 775909 p.Leu858Phe missense_variant 0.15 bedaquiline
clofazimine
mmpL5 775915 p.Ala856Ser missense_variant 0.16 bedaquiline
clofazimine
mmpL5 775916 c.2565T>C synonymous_variant 0.15 bedaquiline
clofazimine
mmpL5 775921 c.2560C>T synonymous_variant 0.15 bedaquiline
clofazimine
mmpL5 775924 c.2557C>T synonymous_variant 0.14 bedaquiline
clofazimine Not assoc w R - Interim
mmpL5 775951 c.2530C>T synonymous_variant 0.23 bedaquiline
clofazimine
mmpL5 775966 p.Ala839Ser missense_variant 0.2 bedaquiline
clofazimine
mmpL5 775970 c.2511G>C synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 775975 c.2506T>C synonymous_variant 0.16 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.19 bedaquiline
clofazimine
mmpL5 776030 c.2451G>C synonymous_variant 0.17 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.16 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.24 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.23 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.24 streptomycin
rpsL 781732 c.174_177delGAGT frameshift_variant 0.17 streptomycin Uncertain significance
rpsL 781740 c.180_181insCGGC frameshift_variant 0.16 streptomycin Uncertain significance
rpsL 781742 c.183C>T synonymous_variant 0.15 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.23 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.25 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.2 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.23 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.22 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.28 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.21 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.21 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.24 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.25 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.23 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.25 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.24 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.24 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.22 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.18 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.18 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.19 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.21 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.2 streptomycin Uncertain significance
rplC 800516 c.-293G>C upstream_gene_variant 0.14 linezolid
rplC 800543 c.-266C>T upstream_gene_variant 0.16 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.16 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.18 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.18 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.2 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.23 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.22 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.21 linezolid
rplC 800603 c.-206G>C upstream_gene_variant 0.22 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.25 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.24 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.24 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.21 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.21 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.22 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 0.26 linezolid
rplC 800684 c.-125G>A upstream_gene_variant 0.25 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.26 linezolid
rplC 800702 c.-107G>A upstream_gene_variant 0.23 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.24 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.22 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.21 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.21 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.22 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.16 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.14 linezolid
fbiC 1304526 c.1596T>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304533 c.1603T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304541 c.1611C>A synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304544 c.1614T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304546 p.Val539Ala missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304562 c.1632G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304567 p.Phe546Tyr missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304571 c.1641G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304649 c.1719C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304671 p.Val581Thr missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Asp missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>T synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.26 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304751 c.1821C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.14 pyrazinamide
sigE 1364898 c.486C>T synonymous_variant 0.18 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.2 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.2 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.21 pyrazinamide
sigE 1364931 c.519C>T synonymous_variant 0.2 pyrazinamide
sigE 1364950 p.Ala180Ser missense_variant 0.16 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472120 n.275G>A non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472223 n.378C>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472228 n.383G>C non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472245 n.400C>A non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472251 n.406G>C non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472279 n.434T>G non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472506 n.661A>T non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472572 n.727T>A non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472591 n.746G>A non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.24 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473047 n.1202C>T non_coding_transcript_exon_variant 0.34 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473091 n.1246G>A non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>A non_coding_transcript_exon_variant 0.28 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473094 n.1249T>A non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.28 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>C non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473121 n.1276_1278delTTAinsCTT non_coding_transcript_exon_variant 0.41 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473157 n.1312C>T non_coding_transcript_exon_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.32 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443delCinsAGTTT non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1453delGGGAGGGAinsTGGAGGGG non_coding_transcript_exon_variant 0.36 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473305 n.1460G>T non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1473811 n.154_155insT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473814 n.158delT non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473829 n.172G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474091 n.434C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474096 n.439C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474102 n.446_449delAGTA non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474108 n.451C>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474110 n.453_454insCGGTG non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474287 n.630_633delTCCTinsACCA non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474292 n.636_649delTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474308 n.651_652insTT non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474584 n.927C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474694 n.1037C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474709 n.1053_1056delTGGTinsACAA non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474716 n.1059_1063delAAAGCinsCCAAGAGT non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.14 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474806 n.1149A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474822 n.1165G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475354 n.1697A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475379 n.1722G>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1475381 n.1724G>C non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1475382 n.1725A>G non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1475395 n.1738T>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid Uncertain significance
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475398 n.1741C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475696 n.2039T>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475697 n.2040C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475963 n.2306G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.8 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448_2449delGAinsAT non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476519 n.2862C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476534 n.2877A>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rpsA 1833589 c.48A>C synonymous_variant 0.18 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.17 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.17 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.23 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.23 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.22 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.21 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.21 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.19 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1833709 c.168C>T synonymous_variant 0.16 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.14 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.17 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.21 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.25 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.26 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.27 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.18 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.17 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.16 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.18 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.19 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.19 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.19 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.14 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.17 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.13 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.14 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223051 p.Glu38Asp missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.17 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.13 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.13 isoniazid
kasA 2518919 p.Gly269Ser missense_variant 1.0 isoniazid
pepQ 2860342 p.Asp26Ala missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv2752c 3065824 p.Pro123Leu missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
thyA 3073868 p.Thr202Ala missense_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624701 c.210T>G synonymous_variant 0.13 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625117 c.-207T>G upstream_gene_variant 0.13 rifampicin
bedaquiline
lpqB 3625122 c.-212C>A upstream_gene_variant 0.13 rifampicin
bedaquiline
mtrB 3625149 p.Val489Ile missense_variant 0.14 rifampicin
bedaquiline
mtrB 3625754 p.Ala287His missense_variant 0.14 rifampicin
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
rpoA 3877704 c.804G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.17 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.18 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.16 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.19 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877770 c.735_738delGTCAinsCAGC synonymous_variant 0.2 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.24 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.24 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.24 rifampicin
rpoA 3877875 c.633T>A synonymous_variant 0.27 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.28 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.26 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877899 c.609C>T synonymous_variant 0.22 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.22 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.23 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.24 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>C synonymous_variant 0.21 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.21 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.18 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.18 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.17 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.17 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>G synonymous_variant 0.17 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.17 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.17 rifampicin
rpoA 3878061 c.447G>A synonymous_variant 0.19 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.22 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.22 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.28 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.25 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.21 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.19 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.19 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>A synonymous_variant 0.23 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.23 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878238 c.270C>T synonymous_variant 0.2 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.18 rifampicin
rpoA 3878247 c.261G>A synonymous_variant 0.19 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.18 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.19 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.17 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
clpC1 4038287 c.2418C>T synonymous_variant 0.95 pyrazinamide Not assoc w R
clpC1 4038584 c.2121G>A synonymous_variant 0.17 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.23 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.2 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.2 pyrazinamide
clpC1 4038660 c.2044_2045delTCinsAG synonymous_variant 0.2 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038679 p.Pro676Ala missense_variant 0.22 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.21 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038776 c.1929G>A synonymous_variant 0.2 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.2 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039064 c.1641C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.24 pyrazinamide
clpC1 4039100 c.1605C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.2 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.23 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039320 p.Ala462Gly missense_variant 0.24 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.23 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.2 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039361 c.1344C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.22 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.2 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 0.14 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.15 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039985 c.720G>A synonymous_variant 0.2 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>T synonymous_variant 0.14 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040492 c.213G>A synonymous_variant 0.14 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.15 pyrazinamide
glpK 4138634 c.1122G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138646 c.1110G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138661 c.1095T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138670 c.1086G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138696 p.Pro354Thr missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4138697 c.1059C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138703 c.1053C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138727 c.1029C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138747 c.1009C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138763 c.993G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138769 c.987G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138778 c.978C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138781 c.975G>T synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138799 c.957T>G synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138808 c.948G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138817 p.Ala313Ser missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138822 p.Asn312Asp missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138823 c.933G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138829 c.927A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247464 c.951C>G synonymous_variant 0.14 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.15 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.16 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.17 ethambutol
embB 4247511 p.Tyr333Phe missense_variant 0.15 ethambutol
embB 4247527 c.1014G>C synonymous_variant 0.14 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.15 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.14 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.15 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.14 ethambutol
embB 4248143 p.Leu544Met missense_variant 0.14 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248158 p.Cys549Ser missense_variant 0.18 ethambutol
embB 4248167 p.Thr552Ala missense_variant 0.2 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.2 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.2 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.2 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.2 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.2 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R