TB-Profiler result

Run: ERR9786526
Summary

Run ID: ERR9786526

Sample name:

Date: 2024-04-15T07:20:49.727626

Number of reads: 1979100

Percentage reads mapped: 77.63

Median coverage: 80.0

Strain: lineage4.1;lineage4.8

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.79
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 0.1
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 371 p.Pro124Leu missense_variant 0.34 isoniazid Not assoc w R
dnaA 1029 c.1029C>T synonymous_variant 0.15 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.17 isoniazid
dnaA 1080 c.1080C>G synonymous_variant 0.16 isoniazid
gyrB 6507 p.Ala423Val missense_variant 0.61 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6532 c.-770C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6583 c.-719G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6586 c.-716T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.19 levofloxacin Uncertain significance
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.19 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6838 c.-464C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6889 c.-413G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6970 c.-332C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7021 c.-281G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7030 c.-272C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7559 c.258G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.8 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7655 c.354G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7727 c.426G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7769 c.468C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7778 c.477G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8552 c.1251C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8885 c.1584C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9002 c.1701C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 0.79 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9656 c.2355C>G synonymous_variant 0.78 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13404 p.Ser52Thr missense_variant 0.21 isoniazid Uncertain significance
fgd1 490987 p.Leu69Val missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490998 c.216T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491064 c.282A>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491083 p.Val101Ile missense_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491115 c.333G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491168 p.Phe129Tyr missense_variant 0.16 clofazimine
pretomanid
delamanid
mshA 575674 c.327G>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575692 c.345G>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.2 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.22 ethionamide
isoniazid
mshA 575722 c.375G>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575746 c.399C>T synonymous_variant 0.21 ethionamide
isoniazid
mshA 575770 c.423G>T synonymous_variant 0.21 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.21 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575833 c.486C>T synonymous_variant 0.27 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575845 c.498C>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575878 c.531A>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.19 ethionamide
isoniazid
ccsA 619574 c.-317G>A upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
Rv0565c 657219 p.Ala84Val missense_variant 0.18 ethionamide
Rv0565c 657233 p.Ile80Val missense_variant 0.18 ethionamide
Rv0565c 657237 c.234A>G synonymous_variant 0.18 ethionamide
Rv0565c 657241 p.Glu77Arg missense_variant 0.18 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.2 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.2 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.2 ethionamide
Rv0565c 657267 c.202_204delTCGinsCC frameshift_variant&synonymous_variant 0.2 ethionamide Uncertain significance
hadA 732389 p.Ser154Thr missense_variant 0.16 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.18 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.18 isoniazid
nusG 734460 c.207G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.18 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>T synonymous_variant 0.16 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.23 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.24 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.21 rifampicin
nusG 734596 c.343_345delTTGinsCC frameshift_variant&missense_variant 0.21 rifampicin
nusG 734604 c.351C>T synonymous_variant 0.21 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.18 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.18 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.22 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.22 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.3 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.3 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.3 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.3 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.32 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.21 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.32 rifampicin
rpoB 760412 c.606C>T synonymous_variant 0.22 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760520 c.714C>G synonymous_variant 0.33 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.32 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.31 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.3 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.34 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.24 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.25 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.24 rifampicin
rpoB 760765 p.Glu320Ala missense_variant 0.24 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.24 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.26 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.27 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.26 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.23 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.21 rifampicin
rpoB 760856 c.1050C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.19 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.2 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.22 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.22 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.22 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.22 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.2 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.24 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.25 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.31 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>G synonymous_variant 0.42 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.42 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.43 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.33 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.17 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.16 rifampicin
rpoB 761437 p.Ala544Glu missense_variant 0.16 rifampicin
rpoB 761439 p.Asp545Asn missense_variant 0.16 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.16 rifampicin
rpoB 761452 p.Val549Asp missense_variant 0.16 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.16 rifampicin
rpoB 761465 c.1659G>C synonymous_variant 0.19 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.19 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.21 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.21 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.21 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.17 rifampicin
rpoB 761579 c.1773G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.22 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.21 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.17 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.18 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.2 rifampicin
rpoB 761699 c.1893C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761711 c.1905C>G synonymous_variant 0.17 rifampicin
rpoB 761714 c.1908C>G synonymous_variant 0.17 rifampicin
rpoB 761717 c.1911C>G synonymous_variant 0.17 rifampicin
rpoB 761735 c.1929C>G synonymous_variant 0.18 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.19 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.2 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.17 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.17 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.17 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.16 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.19 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.19 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.17 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.21 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.31 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.3 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.29 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762074 c.2268C>G synonymous_variant 0.29 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.32 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.32 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.31 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.21 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.21 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.2 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.22 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.2 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.18 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.17 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.21 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762449 c.2643C>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.24 rifampicin Uncertain significance
rpoB 762789 p.Leu995Met missense_variant 0.24 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.23 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.23 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.23 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762833 c.3027C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762863 c.-507T>G upstream_gene_variant 0.26 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.34 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.4 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.4 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 762998 c.-372G>A upstream_gene_variant 0.23 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.22 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.2 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.28 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>C upstream_gene_variant 0.19 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.2 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.2 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.2 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.16 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.28 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763561 c.192G>A synonymous_variant 0.22 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.35 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.33 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.36 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.4 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.39 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.39 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.39 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.38 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.38 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.34 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.37 rifampicin
rpoC 763852 c.483C>G synonymous_variant 0.38 rifampicin
rpoC 763853 c.484_486delGTCinsAT frameshift_variant&missense_variant 0.38 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.37 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.35 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.33 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.32 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.31 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.31 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763933 c.564C>G synonymous_variant 0.26 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.22 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.24 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.24 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.25 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.26 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.26 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.24 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.28 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.33 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.36 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.3 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.31 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.31 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764198 c.829C>T synonymous_variant 0.35 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.34 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764213 p.Arg282Lys missense_variant 0.34 rifampicin Uncertain significance
rpoC 764257 c.888G>C synonymous_variant 0.32 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.33 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.33 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.31 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>A synonymous_variant 0.25 rifampicin
rpoC 764383 c.1014C>G synonymous_variant 0.25 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.26 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.27 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.26 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.27 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.27 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.2 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.18 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.19 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.17 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.22 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.23 rifampicin
rpoC 764647 c.1278C>T synonymous_variant 0.25 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764720 c.1351C>T synonymous_variant 0.18 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.32 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.33 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.33 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.31 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.23 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.18 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.19 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.19 rifampicin
rpoC 765150 p.Gly594Glu missense_variant 0.82 rifampicin Not assoc w R
rpoC 765187 c.1818C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 765361 c.1992C>A synonymous_variant 0.16 rifampicin
rpoC 765370 c.2001G>T synonymous_variant 0.16 rifampicin
rpoC 765371 c.2002C>T synonymous_variant 0.16 rifampicin
rpoC 765379 c.2010G>T synonymous_variant 0.17 rifampicin
rpoC 765383 c.2014_2016delATGinsCT frameshift_variant&missense_variant 0.18 rifampicin
rpoC 765394 c.2025G>A synonymous_variant 0.19 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.19 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.19 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.2 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.22 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.22 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765523 c.2154C>T synonymous_variant 0.22 rifampicin
rpoC 765529 c.2160C>T synonymous_variant 0.3 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.29 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.28 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.29 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.27 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.27 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.33 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.25 rifampicin
rpoC 765637 c.2268C>T synonymous_variant 0.22 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.34 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.35 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.34 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.33 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.35 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.35 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.33 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.33 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.3 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.26 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>G synonymous_variant 0.26 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2643delTCCinsAG frameshift_variant&synonymous_variant 0.17 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.17 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.18 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.2 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.21 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.19 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.19 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.2 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766411 c.3042C>G synonymous_variant 0.2 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.19 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.23 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.24 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.23 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.23 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.21 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.2 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.22 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.22 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.22 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.23 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.22 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.22 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.25 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.27 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.26 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.24 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.22 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.22 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.21 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.21 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.31 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.23 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.19 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.18 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.18 rifampicin
rpoC 766918 c.3549C>G synonymous_variant 0.17 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.18 rifampicin
rpoC 766924 p.Glu1185Asp missense_variant 0.17 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.17 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.17 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.16 rifampicin
rpoC 767134 c.3765C>A synonymous_variant 0.15 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775909 p.Leu858Phe missense_variant 0.17 clofazimine
bedaquiline
mmpL5 776656 p.Gly609Arg missense_variant 0.2 clofazimine Uncertain significance
bedaquiline Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781421 c.-139C>A upstream_gene_variant 0.89 streptomycin Uncertain significance
rpsL 781628 c.69T>C synonymous_variant 0.19 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.23 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.23 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.27 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.29 streptomycin
rpsL 781718 c.159C>T synonymous_variant 0.28 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.29 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.29 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.28 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.28 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.28 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.29 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.27 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.26 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.28 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.28 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.28 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.31 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.31 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.3 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.29 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.28 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.28 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.34 streptomycin Uncertain significance
fbiC 1303746 c.816T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304001 c.1071C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304610 c.1680C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304625 c.1695C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Glu missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304796 c.1866G>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304853 c.1923C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304880 c.1950C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304995 c.2065T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305014 p.Thr695Ser missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305039 c.2109G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473752 n.95G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473936 n.279A>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.58 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475758 n.2104delC non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673679 c.-523T>C upstream_gene_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673682 c.-520G>C upstream_gene_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
fabG1 1673710 c.271_273delCTAinsAC frameshift_variant&missense_variant 0.18 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.19 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.23 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.24 ethionamide
isoniazid
fabG1 1673758 p.Lys107Gln missense_variant 0.24 ethionamide
isoniazid
inhA 1674324 c.123C>T synonymous_variant 0.19 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674331 c.130C>T synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674336 c.135G>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674352 p.Thr51Ala missense_variant 0.18 ethionamide Uncertain significance
isoniazid
inhA 1674368 p.Ala56Glu missense_variant 0.19 ethionamide
isoniazid
inhA 1674375 c.174C>G synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674471 c.270G>T synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674489 c.288G>T synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.44 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.39 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.38 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.4 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.42 ethionamide
isoniazid
inhA 1674624 c.423A>T synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674729 c.528G>T synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674746 p.Tyr182Phe missense_variant 0.28 ethionamide
isoniazid
inhA 1674750 c.549T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674756 c.555T>A synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674786 c.585G>A synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674804 c.603G>C synonymous_variant 0.31 ethionamide Not assoc w R - Interim
isoniazid
inhA 1674816 c.615T>G synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674837 c.636C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674840 c.639C>G synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.33 ethionamide
isoniazid
inhA 1674858 c.657G>A synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.27 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.18 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.19 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.18 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1833793 c.252C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.31 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.3 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.23 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.23 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.25 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834546 c.1005T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.36 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.28 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834684 c.1143C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.17 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.29 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.3 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.29 linezolid
tsnR 1853390 c.-216G>A upstream_gene_variant 0.3 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.29 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.27 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.28 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.28 linezolid
tsnR 1853444 c.-162C>T upstream_gene_variant 0.25 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.24 linezolid
tsnR 1853459 c.-147G>T upstream_gene_variant 0.21 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.19 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 0.71 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2155824 c.288C>T synonymous_variant 0.84 isoniazid Not assoc w R - Interim
katG 2156007 c.105C>T synonymous_variant 0.79 isoniazid Not assoc w R - Interim
PPE35 2168448 p.Gln722Arg missense_variant 0.61 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223421 c.-257G>A upstream_gene_variant 0.79 clofazimine
bedaquiline
kasA 2517917 c.-198G>T upstream_gene_variant 0.18 isoniazid
kasA 2517926 c.-189G>A upstream_gene_variant 0.19 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.2 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.18 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.2 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.17 isoniazid
kasA 2518031 c.-84G>T upstream_gene_variant 0.16 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.19 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.2 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.21 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.23 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.25 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.23 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.23 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.23 isoniazid
kasA 2518705 c.591T>G synonymous_variant 0.24 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.24 isoniazid
kasA 2518714 c.600A>T synonymous_variant 0.24 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.25 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.24 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.24 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.22 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.2 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.19 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.19 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.21 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.19 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.2 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.19 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.17 isoniazid
Rv2477c 2782669 c.1374A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782680 c.1363T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782684 c.1359T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782705 c.1338G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782714 c.1329A>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782720 c.1323T>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782729 c.1314A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782732 c.1311A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782913 p.Ser377Ile missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782928 p.Thr372Gln missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.31 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.38 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783193 p.Ser284Gly missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783244 p.Thr267Ala missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783296 c.747C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783586 p.Ala153Pro missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783695 c.348C>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783770 c.273G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783812 c.231G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783838 p.Thr69Ser missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783853 c.190C>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859843 c.576G>C synonymous_variant 0.18 clofazimine
bedaquiline
pepQ 2859857 p.Val188Met missense_variant 0.16 clofazimine
bedaquiline
thyX 3067373 c.573C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067427 c.519G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067499 c.447G>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.18 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.18 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.18 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.18 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.16 para-aminosalicylic_acid
thyX 3067559 p.Arg129Gln missense_variant 0.16 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.16 para-aminosalicylic_acid
thyX 3067571 c.375C>T synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067586 c.360C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.19 para-aminosalicylic_acid
thyX 3067616 c.330C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074440 p.Val11Ala missense_variant 0.26 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 0.82 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 0.76 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625093 p.Glu507Asp missense_variant 0.16 bedaquiline
rifampicin
lpqB 3625117 c.-207T>G upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625135 c.-225A>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625138 c.-228C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625141 c.-231T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625144 c.-234G>A upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.21 bedaquiline
rifampicin
lpqB 3625156 c.-246G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.2 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625183 c.-273G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625189 c.-279A>T upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625195 c.-285A>G upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625198 c.-288C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625204 c.1408_1410delTCGinsGC frameshift_variant&missense_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625222 c.1392T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625243 c.-333T>G upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625246 c.-336G>A upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625255 c.-345T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.23 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625741 c.-831G>A upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.29 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.27 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625798 c.-888G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625852 c.762A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625888 c.726G>A synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625909 c.-999T>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625927 c.687T>C synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3625930 c.684C>G synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3625936 c.678C>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625942 c.672C>G synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3625945 c.669A>G synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3626684 c.-71G>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626708 c.642G>A synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626711 c.-98T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626720 c.-107G>A upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626732 c.-119A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626735 c.-122C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626744 c.-131G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.19 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626849 c.-236C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627023 c.-410C>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3627056 c.294C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627065 c.-452G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.162A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627269 c.81G>T synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627293 c.57G>A synonymous_variant 0.7 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
alr 3840764 c.657G>C synonymous_variant 0.18 cycloserine
rpoA 3877587 c.921A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.19 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.24 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.25 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.29 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.34 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>G synonymous_variant 0.29 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.31 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.3 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.28 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Asn missense_variant 0.25 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.23 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.22 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.24 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.24 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.25 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.25 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.26 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.27 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.28 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.27 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.28 rifampicin
rpoA 3878064 c.444G>T synonymous_variant 0.27 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.28 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.28 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.29 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.3 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.32 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.31 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.31 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.33 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.27 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.26 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.28 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.31 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.29 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.31 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.32 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.3 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.29 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.29 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.29 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.29 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.27 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.28 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.26 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.27 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.25 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.25 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.23 rifampicin
rpoA 3878458 p.Asn17Ser missense_variant 0.22 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.22 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.21 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.18 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.24 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.21 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.25 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.26 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.2 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.28 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.32 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.32 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.34 rifampicin Uncertain significance
rpoA 3878935 c.-428C>T upstream_gene_variant 0.37 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.37 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878956 c.-449G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.29 rifampicin
rpoA 3878995 c.-488A>G upstream_gene_variant 0.25 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.22 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879028 c.-521C>T upstream_gene_variant 0.2 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.2 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.25 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.27 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.26 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.16 rifampicin
clpC1 4038395 c.2310C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.16 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.27 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.35 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.36 pyrazinamide
clpC1 4038938 c.1767C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.39 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039025 c.1680C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.19 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.16 pyrazinamide
clpC1 4039199 c.1506C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039328 p.Ala459Gly missense_variant 0.16 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.17 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039364 c.1341C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.27 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.29 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039466 c.1239T>G synonymous_variant 0.31 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.3 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039595 c.1110C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.18 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039991 c.714G>T synonymous_variant 0.18 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.18 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.21 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.19 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.2 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>A synonymous_variant 0.19 pyrazinamide
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.18 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040342 c.363C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040477 c.228G>A synonymous_variant 0.16 pyrazinamide
glpK 4138436 c.1320C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138547 c.1209C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138580 c.1176C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138661 c.1095T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139207 c.549T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139228 c.526_528delCCGinsGC frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139231 c.525A>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240615 c.753G>C synonymous_variant 0.18 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.18 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.24 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.23 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.22 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.24 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.25 ethambutol
embC 4240698 p.Ala279Gly missense_variant 0.26 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.24 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.24 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.24 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.26 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.26 ethambutol
embC 4240859 p.Leu333Val missense_variant 0.25 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.26 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.23 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.23 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.23 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.25 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.25 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.25 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.24 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.22 ethambutol
embC 4240945 c.1083T>C synonymous_variant 0.22 ethambutol
embC 4240951 c.1089C>G synonymous_variant 0.2 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.2 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.2 ethambutol
embC 4240966 c.1104G>C synonymous_variant 0.21 ethambutol
embC 4240978 c.1116G>A synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4240979 p.Thr373Gln missense_variant 0.21 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.2 ethambutol
embC 4240990 c.1128A>C synonymous_variant 0.21 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.21 ethambutol
embC 4241020 c.1158G>C synonymous_variant 0.21 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.22 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.21 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.19 ethambutol
embC 4241048 c.1186_1188delCTTinsTG frameshift_variant&missense_variant 0.19 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.2 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.21 ethambutol
embC 4241230 c.1368A>G synonymous_variant 0.21 ethambutol
embC 4241248 c.1386G>C synonymous_variant 0.16 ethambutol
embC 4241249 c.1387_1389delCGTinsAA frameshift_variant&missense_variant 0.16 ethambutol
embC 4241256 p.Arg465Lys missense_variant 0.17 ethambutol
embC 4241259 p.Arg466Leu missense_variant 0.16 ethambutol
embC 4241266 c.1404C>T synonymous_variant 0.17 ethambutol
embC 4241268 p.Val469Ala missense_variant 0.17 ethambutol
embC 4241272 c.1410A>G synonymous_variant 0.18 ethambutol
embC 4241287 c.1425G>C synonymous_variant 0.18 ethambutol
embC 4241288 c.1426_1428delATCinsCG frameshift_variant&missense_variant 0.18 ethambutol
embC 4241301 p.Ala480Val missense_variant 0.18 ethambutol Uncertain significance
embC 4241305 c.1443C>G synonymous_variant 0.18 ethambutol
embC 4241319 p.Pro486Leu missense_variant 0.19 ethambutol
embC 4241326 c.1464T>C synonymous_variant 0.18 ethambutol
embC 4241329 c.1467T>C synonymous_variant 0.18 ethambutol
embC 4241338 c.1476C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241339 p.Phe493Leu missense_variant 0.19 ethambutol
embC 4241344 c.1482G>C synonymous_variant 0.19 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.16 ethambutol
embC 4241528 p.Arg556Ser missense_variant 0.15 ethambutol Uncertain significance
embC 4241539 c.1677T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241551 c.1689A>G synonymous_variant 0.17 ethambutol
embC 4241560 c.1698C>G synonymous_variant 0.19 ethambutol
embC 4241567 p.Ile569Ala missense_variant 0.21 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.21 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.2 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.2 ethambutol
embC 4241591 c.1729_1731delCTCinsGG frameshift_variant&missense_variant 0.2 ethambutol
embC 4241608 c.1746C>G synonymous_variant 0.21 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.21 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.2 ethambutol
embC 4241617 c.1755G>A synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.72 ethambutol Not assoc w R
embA 4244262 c.1030C>T synonymous_variant 0.72 ethambutol Not assoc w R - Interim
embA 4244372 c.1140T>G synonymous_variant 0.18 ethambutol
embA 4244378 c.1146G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embA 4245041 c.1809C>G synonymous_variant 0.17 ethambutol
embA 4245053 c.1821G>C synonymous_variant 0.19 ethambutol
embA 4245056 c.1824C>G synonymous_variant 0.2 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.19 ethambutol
embA 4245078 p.Trp616Val missense_variant 0.17 ethambutol
embA 4245083 c.1851A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embA 4245093 p.Ile621Val missense_variant 0.21 ethambutol Uncertain significance
embA 4245101 c.1869G>C synonymous_variant 0.19 ethambutol
embA 4245143 c.1911C>T synonymous_variant 0.2 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.2 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.2 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.18 ethambutol
embB 4247857 c.1344C>A synonymous_variant 0.16 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.19 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.19 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.18 ethambutol
embB 4247974 c.1461C>G synonymous_variant 0.18 ethambutol
embB 4247980 c.1467C>A synonymous_variant 0.21 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.24 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.25 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.25 ethambutol Uncertain significance
embB 4248044 p.Lys511Ser missense_variant 0.23 ethambutol
embB 4248052 c.1539G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248055 c.1542G>C synonymous_variant 0.23 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.25 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.26 ethambutol
embB 4248088 c.1575C>T synonymous_variant 0.26 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.25 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.24 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.22 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.22 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.22 ethambutol
embB 4248149 c.1636_1638delACCinsGG frameshift_variant&missense_variant 0.21 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248160 c.1647C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4248169 c.1656C>G synonymous_variant 0.23 ethambutol
embB 4248172 c.1659G>C synonymous_variant 0.22 ethambutol
embB 4248175 c.1662G>C synonymous_variant 0.22 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.21 ethambutol
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.18 ethambutol
embB 4248211 c.1698G>T synonymous_variant 0.18 ethambutol
embB 4248214 c.1701C>G synonymous_variant 0.18 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248226 c.1713G>C synonymous_variant 0.2 ethambutol
ubiA 4269164 p.Leu224Met missense_variant 0.17 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.78 capreomycin
amikacin
kanamycin
gid 4407650 p.Asp185Asn missense_variant 0.2 streptomycin Uncertain significance