TB-Profiler result

Run: ERR6866125
Summary

Run ID: ERR6866125

Sample name:

Date: 2024-10-05T04:45:03.141381

Number of reads: 493774

Percentage reads mapped: 28.09

Median coverage: 14.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.99
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 1.0
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6655 c.-647T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6663 p.Phe475Tyr missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrB 6737 p.Thr500Ala missense_variant 0.58 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6742 c.-560A>G upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6749 p.Ala504Ser missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrB 6764 p.Leu509Phe missense_variant 0.48 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
mshA 575679 p.Asn111Ser missense_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 1.0 ethionamide Uncertain significance
nusG 734443 p.Ala64Thr missense_variant 0.33 rifampicin
nusG 734448 c.195C>T synonymous_variant 0.33 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.32 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.32 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734463 c.210G>C synonymous_variant 0.33 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734505 c.252G>T synonymous_variant 0.47 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760115 c.309C>T synonymous_variant 0.71 rifampicin Not assoc w R
rpoB 760274 p.Glu156Asp missense_variant 0.31 rifampicin Uncertain significance
rpoB 760283 c.477G>A synonymous_variant 0.33 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760337 c.531C>G synonymous_variant 0.44 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.46 rifampicin
rpoB 760356 p.Thr184Ser missense_variant 0.54 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760368 c.562_563delTCinsAG synonymous_variant 0.56 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.6 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.65 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760407 p.Ser201Gly missense_variant 0.6 rifampicin Uncertain significance
rpoB 760412 c.606C>T synonymous_variant 0.6 rifampicin
rpoB 760916 c.1110C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.39 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.37 rifampicin
rpoB 760931 c.1125C>G synonymous_variant 0.4 rifampicin
rpoB 760940 c.1134G>C synonymous_variant 0.45 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760958 c.1152G>C synonymous_variant 0.52 rifampicin
rpoB 760961 c.1155C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.52 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.54 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.69 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761003 c.1197C>G synonymous_variant 0.62 rifampicin
rpoB 761006 c.1200C>T synonymous_variant 0.62 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.58 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.58 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.61 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 0.69 rifampicin
rpoB 761234 c.1428G>T synonymous_variant 0.67 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>C synonymous_variant 0.64 rifampicin
rpoB 761261 c.1455G>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761274 c.1468C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.58 rifampicin
rpoB 761288 c.1482G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>A synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761540 c.1734C>T synonymous_variant 0.33 rifampicin
rpoB 761549 c.1743G>C synonymous_variant 0.4 rifampicin
rpoB 761555 c.1749G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761996 c.2190C>T synonymous_variant 0.67 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.64 rifampicin
rpoB 762003 p.Asn733Gln missense_variant 0.64 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762026 c.2220G>C synonymous_variant 0.67 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.77 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.71 rifampicin Uncertain significance
rpoB 762128 c.2322G>C synonymous_variant 0.67 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.66 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.68 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762156 p.Val784Ile missense_variant 0.61 rifampicin
rpoB 762161 c.2355C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762189 p.Ile795Val missense_variant 0.64 rifampicin
rpoB 762218 c.2412T>C synonymous_variant 0.62 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.49 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.47 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.43 rifampicin
rpoB 762299 c.2493G>C synonymous_variant 0.43 rifampicin
rpoB 762308 c.2502G>C synonymous_variant 0.46 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.44 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762812 c.3006C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762814 p.Met1003Thr missense_variant 0.32 rifampicin Uncertain significance
rpoB 762818 c.3012C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762827 c.-543G>T upstream_gene_variant 0.35 rifampicin
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762858 p.Thr1018Ser missense_variant 0.61 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762881 p.Met1025Ile missense_variant 0.68 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 762971 c.-399G>C upstream_gene_variant 0.73 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.75 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.68 rifampicin
rpoC 763022 c.-348C>G upstream_gene_variant 0.63 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.61 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763067 c.-303C>G upstream_gene_variant 0.57 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.62 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.62 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.39 rifampicin
rpoC 763160 c.-210G>C upstream_gene_variant 0.37 rifampicin
rpoC 763411 c.42T>C synonymous_variant 0.33 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763430 c.61_63delAGGinsCGC synonymous_variant 0.37 rifampicin
rpoC 763433 p.Gln22Asn missense_variant 0.38 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763507 c.138G>C synonymous_variant 0.77 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.76 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.75 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.73 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.76 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763624 c.255C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.45 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.32 rifampicin
rpoC 763708 c.339G>T synonymous_variant 0.33 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.32 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>T synonymous_variant 0.3 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.29 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.3 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 0.57 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.57 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.54 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.58 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764296 c.927G>C synonymous_variant 0.66 rifampicin
rpoC 764308 c.939G>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764320 c.951C>T synonymous_variant 0.61 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.67 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764368 c.999C>T synonymous_variant 0.68 rifampicin
rpoC 764371 c.1002G>T synonymous_variant 0.67 rifampicin
rpoC 764377 c.1008C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.58 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.54 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.54 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.56 rifampicin
rpoC 764455 c.1086G>T synonymous_variant 0.58 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764506 c.1137C>T synonymous_variant 0.65 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.6 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>G synonymous_variant 0.67 rifampicin
rpoC 764548 c.1179G>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764707 c.1338G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764719 c.1350G>A synonymous_variant 0.7 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.54 rifampicin
rpoC 764785 c.1416C>G synonymous_variant 0.56 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.5 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.48 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.45 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 766996 c.3627C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767017 c.3648C>G synonymous_variant 0.53 rifampicin
rpoC 767062 c.3693C>A synonymous_variant 0.63 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.62 rifampicin
rpoC 767093 c.3724_3726delAGCinsTCG synonymous_variant 0.56 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.58 rifampicin
rpoC 767113 c.3744G>C synonymous_variant 0.62 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 767152 c.3783T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767173 c.3804C>G synonymous_variant 0.5 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.47 rifampicin
rpoC 767185 c.3816G>T synonymous_variant 0.47 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781802 c.243G>C synonymous_variant 0.5 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.48 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.45 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.45 streptomycin
rpsL 781829 c.270G>T synonymous_variant 0.43 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.43 streptomycin
rpsL 781856 c.297C>T synonymous_variant 0.5 streptomycin Not assoc w R - Interim
rpsL 781859 c.300T>C synonymous_variant 0.5 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.46 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.46 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.45 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.47 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.44 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.44 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.44 streptomycin
rplC 800738 c.-71T>C upstream_gene_variant 0.32 linezolid
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.56 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.58 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472312 n.467_468insA non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.89 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472449 n.604C>T non_coding_transcript_exon_variant 0.9 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.9 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.9 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>A non_coding_transcript_exon_variant 0.9 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472467 n.622G>T non_coding_transcript_exon_variant 0.9 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.83 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472837 n.992C>T non_coding_transcript_exon_variant 0.79 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472844 n.999_1004delCGCGTCinsAAGCCG non_coding_transcript_exon_variant 0.86 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472858 n.1013G>C non_coding_transcript_exon_variant 0.83 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.83 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472861 n.1016G>C non_coding_transcript_exon_variant 0.83 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472862 n.1017T>C non_coding_transcript_exon_variant 0.83 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472863 n.1018T>C non_coding_transcript_exon_variant 0.83 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.84 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.84 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472878 n.1033G>A non_coding_transcript_exon_variant 0.84 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.86 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.89 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.94 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473791 n.134A>C non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473792 n.135C>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473793 n.136G>C non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473802 n.145C>G non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473803 n.146G>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473804 n.147T>G non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473814 n.157A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473830 n.173T>C non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474153 n.496C>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474166 n.509G>A non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474220 n.563G>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474411 n.756_778delACCCACACGCGCATACGCGCGTG non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474437 n.780G>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474438 n.781A>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474439 n.782A>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474447 n.790G>A non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474638 n.981C>T non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1052G>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474710 n.1053T>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474711 n.1054G>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474716 n.1059_1060delAAinsGAG non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475065 n.1408G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475067 n.1410A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475481 n.1824C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475482 n.1825A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1475761 n.2104C>A non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>G non_coding_transcript_exon_variant 0.95 capreomycin
linezolid Uncertain significance
rrl 1475766 n.2109G>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.95 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1476047 n.2390G>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.92 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.92 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.92 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.98 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.95 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.95 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.92 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833676 c.135A>G synonymous_variant 0.39 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833682 c.141C>T synonymous_variant 0.39 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.41 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833697 c.156C>T synonymous_variant 0.41 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.37 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.5 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.52 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.52 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.57 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.56 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.56 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.56 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.56 pyrazinamide
rpsA 1833838 c.297G>A synonymous_variant 0.56 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.58 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.58 pyrazinamide
rpsA 1833850 c.309C>G synonymous_variant 0.58 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.54 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.52 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.51 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.54 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.53 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.48 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.48 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.48 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.48 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.47 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.53 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.48 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.44 pyrazinamide
rpsA 1834252 c.711C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.36 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.38 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834307 p.Asp256Asn missense_variant 0.4 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.52 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.53 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>T synonymous_variant 0.45 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834360 c.819G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.47 pyrazinamide
rpsA 1834378 c.837T>G synonymous_variant 0.53 pyrazinamide
rpsA 1834384 c.843A>G synonymous_variant 0.56 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.56 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.58 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.63 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCTC synonymous_variant 0.65 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.55 pyrazinamide
rpsA 1834474 c.933C>T synonymous_variant 0.48 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834570 c.1029C>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1834574 p.Met345Leu missense_variant 0.47 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.48 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834612 c.1071G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834627 c.1086C>G synonymous_variant 0.52 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.48 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834650 p.Thr370Asn missense_variant 0.4 pyrazinamide
rpsA 1834653 p.Glu371Ala missense_variant 0.4 pyrazinamide
rpsA 1834663 c.1122C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.39 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCG synonymous_variant 0.41 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.35 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.3 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.29 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.29 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517917 c.-198G>C upstream_gene_variant 0.27 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.26 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.25 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.26 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.26 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 0.26 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.25 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
thyA 3073863 c.609T>C synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3073874 p.Ile200Val missense_variant 0.5 para-aminosalicylic_acid
thyA 3073878 p.Glu198Asp missense_variant 0.5 para-aminosalicylic_acid
thyA 3073884 c.588C>G synonymous_variant 0.46 para-aminosalicylic_acid
thyA 3073888 p.Ser195Glu missense_variant 0.46 para-aminosalicylic_acid
thyA 3073890 c.580_582delTTGinsCTC synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3073902 p.Ala190Gln missense_variant 0.4 para-aminosalicylic_acid
thyA 3073905 c.567C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073910 p.Met188Val missense_variant 0.38 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.38 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
fbiD 3339040 c.-78T>C upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrA 3627756 c.-407A>T upstream_gene_variant 1.0 rifampicin
bedaquiline
rpoA 3878283 p.Glu75Asp missense_variant 0.43 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 0.5 rifampicin
rpoA 3878310 c.198G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>C synonymous_variant 0.46 rifampicin
rpoA 3878334 c.174T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878343 c.165C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.46 rifampicin
rpoA 3878358 c.150C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878361 c.147G>T synonymous_variant 0.46 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.46 rifampicin
clpC1 4038746 c.1959C>T synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4038749 c.1956C>T synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>T synonymous_variant 0.4 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.47 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.47 pyrazinamide
clpC1 4038791 c.1914G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038794 p.Ser637Thr missense_variant 0.53 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038815 c.1890G>A synonymous_variant 0.54 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038881 c.1824C>T synonymous_variant 0.57 pyrazinamide
clpC1 4038890 c.1815G>A synonymous_variant 0.61 pyrazinamide
clpC1 4038905 c.1800A>T synonymous_variant 0.62 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.62 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.62 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.62 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.64 pyrazinamide
clpC1 4038926 c.1779G>T synonymous_variant 0.65 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.62 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.63 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.7 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.7 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4038997 c.1708T>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.67 pyrazinamide
clpC1 4039007 c.1698G>C synonymous_variant 0.66 pyrazinamide
clpC1 4039010 c.1695G>A synonymous_variant 0.68 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.66 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4039082 c.1623C>T synonymous_variant 0.44 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.48 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.49 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039133 c.1572C>T synonymous_variant 0.46 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.4 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.5 pyrazinamide
clpC1 4039217 c.1488G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039279 p.Val476Ile missense_variant 0.43 pyrazinamide
clpC1 4039280 c.1425G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039286 c.1419T>G synonymous_variant 0.43 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039337 c.1368A>C synonymous_variant 0.44 pyrazinamide
clpC1 4039347 p.Arg453Lys missense_variant 0.43 pyrazinamide
clpC1 4039355 c.1350G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039359 p.Ser449Asn missense_variant 0.38 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.36 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039406 c.1299G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039412 c.1293T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.32 pyrazinamide Uncertain significance
clpC1 4039427 p.Glu426Asp missense_variant 0.27 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039499 c.1206G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039508 c.1197G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039598 c.1107C>T synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.56 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.5 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039655 c.1050G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039670 c.1035G>T synonymous_variant 0.5 pyrazinamide
clpC1 4039682 c.1023C>A synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4039691 c.1014G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.51 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.55 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.53 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.53 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.54 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.55 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.58 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.59 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.68 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.71 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.72 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.61 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.63 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.63 pyrazinamide
clpC1 4039982 c.723G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.68 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.67 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.67 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.65 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.65 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.65 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.65 pyrazinamide
clpC1 4040036 c.669C>T synonymous_variant 0.65 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040051 c.654C>G synonymous_variant 0.43 pyrazinamide
clpC1 4040054 c.651G>A synonymous_variant 0.43 pyrazinamide
clpC1 4040063 c.642G>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040066 c.639G>C synonymous_variant 0.35 pyrazinamide
clpC1 4040069 c.636G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040495 c.210C>T synonymous_variant 0.42 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040525 c.180C>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.46 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040540 c.165G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040546 c.159G>T synonymous_variant 0.44 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.37 pyrazinamide
clpC1 4040567 c.138C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040573 c.132T>G synonymous_variant 0.3 pyrazinamide
clpC1 4040582 c.123G>T synonymous_variant 0.25 pyrazinamide
clpC1 4040585 c.120A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040594 c.111G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCTG synonymous_variant 0.24 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.24 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040612 c.93G>A synonymous_variant 0.28 pyrazinamide
clpC1 4040615 c.90C>G synonymous_variant 0.28 pyrazinamide
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embB 4248043 c.1530C>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
whiB6 4338901 c.-380T>G upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4408312 c.-110C>T upstream_gene_variant 1.0 streptomycin