TB-Profiler result

Run: SRR10315551
Summary

Run ID: SRR10315551

Sample name:

Date: 2025-02-11T19:43:14.623700

Number of reads: 3606186

Percentage reads mapped: 61.87

Median coverage: 109.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6680 c.1441C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6737 p.Thr500Ala missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6742 c.-560A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6749 p.Ala504Ser missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6764 p.Leu509Phe missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.21 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6805 c.1566G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.19 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7081 c.-221T>C upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrB 7088 p.Asp617Asn missense_variant 0.13 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.12 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7100 c.1861T>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7123 c.-179C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7124 p.Ser629Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>C upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8867 c.1566A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8876 c.1575C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8913 p.Lys538Arg missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8924 c.1623C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Lys missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8982 p.Cys561Ser missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9002 c.1701C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9018 p.Gln573Lys missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9026 c.1725G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9038 c.1737C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9047 c.1746C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R
gyrA 9050 p.Asp583Glu missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9063 p.Ser588Asn missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCTG synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575907 p.Ala187Val missense_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
nusG 734499 c.246G>C synonymous_variant 0.15 rifampicin
nusG 734505 c.252G>A synonymous_variant 0.15 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.15 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
nusG 734543 p.Arg97Pro missense_variant 0.13 rifampicin
nusG 734548 p.Gln99Lys missense_variant 0.13 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.14 rifampicin
rpoB 760139 c.333A>C synonymous_variant 0.13 rifampicin
rpoB 760140 p.Pro112Ser missense_variant 0.13 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.17 rifampicin
rpoB 760157 c.351A>G synonymous_variant 0.18 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.21 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.22 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760185 c.379C>T synonymous_variant 0.22 rifampicin
rpoB 760199 c.393C>G synonymous_variant 0.23 rifampicin
rpoB 760233 c.427_429delAGTinsTCG synonymous_variant 0.2 rifampicin
rpoB 760241 c.435G>C synonymous_variant 0.19 rifampicin
rpoB 760253 c.447T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760265 p.Met153Ile missense_variant 0.2 rifampicin
rpoB 760274 p.Glu156Asp missense_variant 0.2 rifampicin Uncertain significance
rpoB 760282 p.Thr159Ser missense_variant 0.17 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.3 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.3 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.18 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.18 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761969 p.Glu721Asp missense_variant 0.25 rifampicin Uncertain significance
rpoB 761972 c.2166C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762000 c.2194_2195delTCinsAG synonymous_variant 0.28 rifampicin
rpoB 762003 p.Asn733Gln missense_variant 0.28 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.28 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.29 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.26 rifampicin Uncertain significance
rpoB 762128 c.2322G>C synonymous_variant 0.29 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.3 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.31 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762170 c.2364C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.34 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.29 rifampicin
rpoB 762245 c.2439G>T synonymous_variant 0.28 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762299 c.2493G>C synonymous_variant 0.14 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762858 p.Thr1018Ser missense_variant 0.16 rifampicin
rpoC 762863 c.-507T>G upstream_gene_variant 0.17 rifampicin
rpoB 762881 p.Met1025Ile missense_variant 0.25 rifampicin
rpoC 762887 c.-483G>T upstream_gene_variant 0.25 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.37 rifampicin
rpoB 762989 c.3183G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763067 c.-303C>G upstream_gene_variant 0.38 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.38 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763160 c.-210G>C upstream_gene_variant 0.23 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763597 c.228G>A synonymous_variant 0.32 rifampicin
rpoC 763609 c.240C>G synonymous_variant 0.28 rifampicin
rpoC 763619 p.Arg84Lys missense_variant 0.26 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763648 c.279C>T synonymous_variant 0.26 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.23 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.24 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.24 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.25 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.25 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.25 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.23 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.17 rifampicin
rpoC 763819 c.450G>T synonymous_variant 0.13 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764242 c.873C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.17 rifampicin
rpoC 764254 c.885G>A synonymous_variant 0.22 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.22 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.23 rifampicin
rpoC 764266 c.897T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764269 c.900G>C synonymous_variant 0.22 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>C synonymous_variant 0.27 rifampicin
rpoC 764290 c.921C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.29 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.32 rifampicin
rpoC 764329 c.960C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764341 c.972G>T synonymous_variant 0.33 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.34 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764396 c.1027C>T synonymous_variant 0.26 rifampicin
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.24 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.21 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.21 rifampicin
rpoC 764455 c.1086G>T synonymous_variant 0.22 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764470 c.1101C>G synonymous_variant 0.26 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.27 rifampicin
rpoC 764506 c.1137C>T synonymous_variant 0.27 rifampicin
rpoC 764509 c.1140G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.26 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.42 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.39 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.39 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.36 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.38 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 0.3 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.32 rifampicin
rpoC 764764 p.His465Gln missense_variant 0.35 rifampicin
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.29 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.29 rifampicin Not assoc w R
rpoC 764812 p.Gln482Ala missense_variant 0.29 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>T synonymous_variant 0.27 rifampicin
rpoC 764875 c.1506C>T synonymous_variant 0.27 rifampicin
rpoC 764887 c.1518G>T synonymous_variant 0.23 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.25 rifampicin
rpoC 764908 c.1539G>A synonymous_variant 0.23 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.21 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.21 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765004 c.1635G>C synonymous_variant 0.26 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765013 c.1644C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>G synonymous_variant 0.24 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>G synonymous_variant 0.25 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.25 rifampicin
rpoC 765076 c.1707A>G synonymous_variant 0.24 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.17 rifampicin
rpoC 765874 c.2505G>C synonymous_variant 0.19 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.19 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.19 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765908 p.Leu847Ala missense_variant 0.22 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>C synonymous_variant 0.23 rifampicin
rpoC 765946 c.2577C>T synonymous_variant 0.23 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.22 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.22 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766309 c.2940G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766315 c.2946C>G synonymous_variant 0.14 rifampicin
rpoC 766333 c.2964G>C synonymous_variant 0.23 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.24 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.24 rifampicin
rpoC 766361 p.Val998Ile missense_variant 0.23 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.22 rifampicin
rpoC 766375 c.3006C>G synonymous_variant 0.22 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.23 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.22 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.22 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.23 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766411 c.3042C>G synonymous_variant 0.24 rifampicin
rpoC 766435 p.Glu1022Asp missense_variant 0.2 rifampicin Uncertain significance
rpoC 766456 c.3087C>G synonymous_variant 0.17 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.16 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.16 rifampicin
rpoC 766471 c.3102G>C synonymous_variant 0.14 rifampicin
rpoC 766510 c.3141C>G synonymous_variant 0.16 rifampicin
rpoC 766513 p.Asp1048Glu missense_variant 0.16 rifampicin
rpoC 766517 p.Thr1050Ser missense_variant 0.16 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.17 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.18 rifampicin
rpoC 766534 c.3165C>G synonymous_variant 0.18 rifampicin
rpoC 766542 p.Gly1058Asp missense_variant 0.19 rifampicin
rpoC 766546 p.Glu1059Asp missense_variant 0.17 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.19 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.18 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.17 rifampicin
rpoC 766582 c.3213C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766583 p.Gly1072Ser missense_variant 0.13 rifampicin
rpoC 766684 c.3315C>G synonymous_variant 0.12 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.13 rifampicin
rpoC 766693 c.3324C>T synonymous_variant 0.13 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.12 rifampicin
rpoC 766718 p.Asp1117Asn missense_variant 0.13 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.14 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.16 rifampicin
rpoC 766742 p.Gln1125Met missense_variant 0.16 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.16 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.16 rifampicin
rpoC 766754 p.Glu1129Gln missense_variant 0.16 rifampicin
rpoC 766763 p.Ile1132Val missense_variant 0.15 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.15 rifampicin
rpoC 766775 p.Arg1136Asn missense_variant 0.15 rifampicin
rpoC 766799 p.Ala1144Ser missense_variant 0.15 rifampicin Uncertain significance
rpoC 766804 c.3435A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>A synonymous_variant 0.13 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767017 c.3648C>G synonymous_variant 0.24 rifampicin
rpoC 767023 p.Asp1218Glu missense_variant 0.25 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.25 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.27 rifampicin
rpoC 767065 c.3696G>C synonymous_variant 0.28 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.3 rifampicin
rpoC 767080 c.3711G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767087 p.Cys1240Ser missense_variant 0.28 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.24 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.14 streptomycin
rpsL 781706 c.147T>G synonymous_variant 0.18 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.18 streptomycin Not assoc w R - Interim
rpsL 781721 c.162C>T synonymous_variant 0.18 streptomycin
rpsL 781725 p.Lys56Arg missense_variant 0.18 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.18 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.18 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.18 streptomycin
rpsL 781737 p.Gln60Ser missense_variant 0.18 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.23 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.24 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.24 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.25 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.28 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.24 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.24 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.23 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.22 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.21 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.2 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.17 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.17 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.16 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.16 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.16 streptomycin
rpsL 781884 p.Asn109Asp missense_variant 0.16 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.12 streptomycin
rplC 800633 c.-176T>C upstream_gene_variant 0.17 linezolid
rplC 800645 c.-164C>T upstream_gene_variant 0.19 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.19 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
rplC 800667 c.-142_-140delTCGinsAGC upstream_gene_variant 0.16 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.16 linezolid
rplC 800675 c.-134G>A upstream_gene_variant 0.17 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.15 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.15 linezolid
rplC 800702 c.-107G>A upstream_gene_variant 0.15 linezolid
rplC 800703 c.-106_-104delTTGinsCTC upstream_gene_variant 0.14 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.14 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.14 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.15 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.14 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.14 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80delTinsCAG non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471929 n.84C>G non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471930 n.85G>C non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471931 n.86G>T non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471980 n.135G>T non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1471981 n.136C>G non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472028 n.183_189delACGGGATinsTTACATC non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472055 n.211_212delGC non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472067 n.222G>T non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472068 n.223T>G non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453_467delGTCCGGGTTCTCTCGinsCGT non_coding_transcript_exon_variant 0.43 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.39 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.4 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472445 n.601dupT non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472449 n.604_607delCACGinsGCA non_coding_transcript_exon_variant 0.34 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472463 n.618G>A non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>A non_coding_transcript_exon_variant 0.43 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.44 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472674 n.829T>C non_coding_transcript_exon_variant 0.44 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472680 n.835C>T non_coding_transcript_exon_variant 0.45 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472685 n.840G>A non_coding_transcript_exon_variant 0.45 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.51 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472841 n.996G>A non_coding_transcript_exon_variant 0.5 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.47 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472859 n.1014G>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472960 n.1115G>A non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472986 n.1141C>T non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.34 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473743 n.86C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473750 n.93C>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473811 n.154C>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473812 n.155G>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_175delGGTGCinsCTGGTGT non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473835 n.179delA non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>G non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474264 n.607T>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474265 n.608G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474740 n.1083G>C non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1474747 n.1090C>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475059 n.1404_1405delCA non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475064 n.1407G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475067 n.1410_1411insG non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475080 n.1423G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475081 n.1424C>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475201 n.1544G>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475212 n.1555A>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475221 n.1564C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid Uncertain significance
rrl 1475222 n.1565G>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475246 n.1589C>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475307 n.1650T>G non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475443 n.1786G>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475444 n.1787G>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475481 n.1824C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945_1948delGGAAinsCAT non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475607 n.1950A>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475609 n.1952C>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475614 n.1957A>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475627 n.1970G>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475628 n.1971G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475633 n.1976G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475636 n.1979A>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101delAinsGTG non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475769 n.2113_2114insCG non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476029 n.2373_2377delACCTC non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.64 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.62 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.62 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.63 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833586 c.45C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.14 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.14 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.14 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.15 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.15 pyrazinamide
rpsA 1833623 p.Lys28Ser missense_variant 0.15 pyrazinamide
rpsA 1833658 c.117C>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1833664 c.123C>A synonymous_variant 0.22 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833682 c.141C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.19 pyrazinamide
rpsA 1833739 c.198C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833763 c.222C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833782 p.Ser81Asn missense_variant 0.18 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.29 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833862 c.321G>A synonymous_variant 0.31 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.35 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.42 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.39 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.36 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.36 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.35 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834066 c.525G>A synonymous_variant 0.19 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834151 p.Asn204His missense_variant 0.14 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.14 pyrazinamide
rpsA 1834157 c.616_618delTTGinsCTC synonymous_variant 0.14 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834167 c.628_629delAC frameshift_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834172 c.631_632insGG frameshift_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834183 c.642T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834213 c.672G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834252 c.711C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834282 c.741C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834298 p.Gln253Ala missense_variant 0.27 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.27 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.25 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834345 c.804C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834372 c.831G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834375 c.834G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.2 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.2 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.25 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834483 p.Glu314Asp missense_variant 0.27 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834504 c.963G>T synonymous_variant 0.24 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.25 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834570 c.1029C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834600 c.1059G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834619 c.1078T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.22 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.3 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834738 p.Glu399Asp missense_variant 0.25 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.23 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.22 pyrazinamide
rpsA 1834779 p.Glu413Ala missense_variant 0.21 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834810 c.1269C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834813 c.1272G>C synonymous_variant 0.14 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.99 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
ahpC 2726593 p.Val134Ala missense_variant 0.14 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.16 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.16 isoniazid
ahpC 2726648 c.456T>A synonymous_variant 0.16 isoniazid
ahpC 2726654 c.462G>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
ahpC 2726657 c.465A>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ahpC 2726669 c.477T>C synonymous_variant 0.16 isoniazid
ahpC 2726675 c.483A>C synonymous_variant 0.16 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
ahpC 2726684 c.492G>C synonymous_variant 0.15 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.16 isoniazid
Rv2477c 2783611 c.432C>G synonymous_variant 0.13 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783652 p.His131Asn missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783659 p.Glu128Asp missense_variant 0.13 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783665 c.378A>G synonymous_variant 0.13 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783672 p.Arg124Lys missense_variant 0.13 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.13 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.13 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783689 c.354G>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625797 p.Val273Met missense_variant 0.13 rifampicin Uncertain significance
bedaquiline Uncertain significance
lpqB 3625804 c.-896_-894delAGGinsCGC upstream_gene_variant 0.13 rifampicin
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
rpoA 3877656 c.852T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.13 rifampicin
rpoA 3877665 c.843C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.14 rifampicin
rpoA 3877674 c.834C>G synonymous_variant 0.15 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>T synonymous_variant 0.19 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877734 c.774G>C synonymous_variant 0.25 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.25 rifampicin
rpoA 3877743 p.Asp255Glu missense_variant 0.25 rifampicin
rpoA 3877746 c.762G>C synonymous_variant 0.24 rifampicin
rpoA 3877749 c.759C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.24 rifampicin
rpoA 3877765 p.Ala248Ser missense_variant 0.27 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877803 c.705G>T synonymous_variant 0.24 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877827 c.681C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>C synonymous_variant 0.11 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.12 rifampicin
rpoA 3877898 p.Pro204Ala missense_variant 0.12 rifampicin
rpoA 3877959 c.549C>G synonymous_variant 0.15 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.2 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.21 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878010 c.498C>G synonymous_variant 0.23 rifampicin
rpoA 3878013 c.495T>C synonymous_variant 0.22 rifampicin
rpoA 3878019 c.489A>G synonymous_variant 0.23 rifampicin
rpoA 3878025 c.483C>G synonymous_variant 0.24 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.24 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.24 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.24 rifampicin
rpoA 3878046 c.462T>G synonymous_variant 0.27 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.27 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.27 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.28 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.27 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878102 p.Val136Ile missense_variant 0.25 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.24 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.24 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.22 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.2 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Asp missense_variant 0.15 rifampicin Uncertain significance
rpoA 3878185 p.Gly108Ala missense_variant 0.21 rifampicin
rpoA 3878188 p.Ala107Gly missense_variant 0.2 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Thr missense_variant 0.18 rifampicin
rpoA 3878199 c.309T>C synonymous_variant 0.19 rifampicin
rpoA 3878214 c.294C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878217 p.Leu97Val missense_variant 0.24 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.21 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.19 rifampicin
rpoA 3878251 c.256_257delTCinsAG synonymous_variant 0.19 rifampicin
rpoA 3878259 c.249G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878264 p.Ser82Gly missense_variant 0.19 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.18 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.15 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
clpC1 4038671 c.2034T>G synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
clpC1 4038713 c.1992T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038749 c.1956C>A synonymous_variant 0.18 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.19 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038776 c.1929G>A synonymous_variant 0.21 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.23 pyrazinamide
clpC1 4038810 p.Gln632Ser missense_variant 0.18 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038857 c.1848C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038875 c.1830C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038884 c.1821C>T synonymous_variant 0.3 pyrazinamide
clpC1 4038890 c.1815G>A synonymous_variant 0.3 pyrazinamide
clpC1 4038905 c.1800A>T synonymous_variant 0.3 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.28 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.28 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038926 c.1779G>T synonymous_variant 0.29 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.31 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038977 c.1728G>A synonymous_variant 0.31 pyrazinamide
clpC1 4038986 p.Asp573Glu missense_variant 0.28 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039019 c.1686G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039031 c.1674T>A synonymous_variant 0.27 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039088 c.1617G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039091 c.1614G>A synonymous_variant 0.16 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.19 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCTC synonymous_variant 0.18 pyrazinamide
clpC1 4039184 c.1521G>A synonymous_variant 0.18 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.2 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.2 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039241 c.1464G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039244 c.1461G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039499 c.1206G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.2 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039583 c.1122C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039601 p.Ala368Ser missense_variant 0.25 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039654 p.Thr351Ser missense_variant 0.33 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039694 c.1011G>T synonymous_variant 0.26 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.37 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039787 c.918G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.3 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.31 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.3 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.34 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.32 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.31 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.18 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4336779 c.80_*1391del frameshift_variant&stop_lost&splice_region_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407620 p.Tyr195His missense_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R