TB-Profiler

Lineage	Family	RDs	Frequency
lineage3.1.2.2	East-African-Indian	RD750	0.1
lineage4	Euro-American	None	0.65
lineage4.9	Euro-American (H37Rv-like)	None	0.87

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
embB	4247580	p.Ala356Val	missense_variant	0.97	ethambutol	Uncertain significance	Mutation from literature
embB	4247663	p.Tyr384Asn	missense_variant	0.92	ethambutol		Mutation from literature
embB	4247708	p.Asn399Asp	missense_variant	0.89	ethambutol		Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	21	c.21A>T	synonymous_variant	1.0	isoniazid
dnaA	24	c.24C>T	synonymous_variant	1.0	isoniazid
dnaA	30	c.30C>G	synonymous_variant	1.0	isoniazid
dnaA	33	c.33A>C	synonymous_variant	1.0	isoniazid
gyrB	6172	c.933C>T	synonymous_variant	0.86	levofloxacin
gyrB	6172	c.933C>T	synonymous_variant	0.86	moxifloxacin
gyrB	6190	c.951A>G	synonymous_variant	0.88	levofloxacin
gyrB	6190	c.951A>G	synonymous_variant	0.88	moxifloxacin
gyrB	6214	c.975G>C	synonymous_variant	0.92	levofloxacin
gyrB	6214	c.975G>C	synonymous_variant	0.92	moxifloxacin
gyrB	6238	c.999G>A	synonymous_variant	0.96	levofloxacin	Not assoc w R - Interim
gyrB	6238	c.999G>A	synonymous_variant	0.96	moxifloxacin	Not assoc w R - Interim
gyrB	6242	p.Arg335Lys	missense_variant	0.96	levofloxacin
gyrB	6242	p.Arg335Lys	missense_variant	0.96	moxifloxacin
gyrB	6253	c.1014G>C	synonymous_variant	0.96	levofloxacin
gyrB	6253	c.1014G>C	synonymous_variant	0.96	moxifloxacin
gyrB	6265	c.1026C>T	synonymous_variant	0.92	levofloxacin	Not assoc w R - Interim
gyrB	6265	c.1026C>T	synonymous_variant	0.92	moxifloxacin	Not assoc w R - Interim
gyrB	6280	c.1041T>C	synonymous_variant	0.88	levofloxacin
gyrB	6280	c.1041T>C	synonymous_variant	0.88	moxifloxacin
gyrB	6286	c.1047T>C	synonymous_variant	0.86	levofloxacin
gyrB	6286	c.1047T>C	synonymous_variant	0.86	moxifloxacin
gyrB	6292	c.1053G>A	synonymous_variant	0.86	levofloxacin
gyrB	6292	c.1053G>A	synonymous_variant	0.86	moxifloxacin
gyrB	6298	c.1059C>G	synonymous_variant	0.86	levofloxacin
gyrB	6298	c.1059C>G	synonymous_variant	0.86	moxifloxacin
gyrB	6299	c.1060C>T	synonymous_variant	0.86	levofloxacin
gyrB	6299	c.1060C>T	synonymous_variant	0.86	moxifloxacin
gyrB	6307	c.1068T>G	synonymous_variant	0.86	levofloxacin	Not assoc w R - Interim
gyrB	6307	c.1068T>G	synonymous_variant	0.86	moxifloxacin	Not assoc w R - Interim
gyrA	6316	c.-986G>C	upstream_gene_variant	0.83	levofloxacin
gyrA	6316	c.-986G>C	upstream_gene_variant	0.83	moxifloxacin
gyrB	6326	p.Ser363Ala	missense_variant	0.79	levofloxacin
gyrB	6326	p.Ser363Ala	missense_variant	0.79	moxifloxacin
gyrA	6331	c.-971A>G	upstream_gene_variant	0.79	levofloxacin
gyrA	6331	c.-971A>G	upstream_gene_variant	0.79	moxifloxacin
gyrA	6700	c.-602T>C	upstream_gene_variant	0.82	levofloxacin
gyrA	6700	c.-602T>C	upstream_gene_variant	0.82	moxifloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	0.82	levofloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	0.82	moxifloxacin
gyrA	6706	c.-596G>A	upstream_gene_variant	0.82	levofloxacin
gyrA	6706	c.-596G>A	upstream_gene_variant	0.82	moxifloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	0.82	levofloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	0.82	moxifloxacin
gyrA	6712	c.-590G>C	upstream_gene_variant	0.82	levofloxacin
gyrA	6712	c.-590G>C	upstream_gene_variant	0.82	moxifloxacin
gyrA	6730	c.-572A>G	upstream_gene_variant	0.82	levofloxacin
gyrA	6730	c.-572A>G	upstream_gene_variant	0.82	moxifloxacin
gyrA	6733	c.-569G>A	upstream_gene_variant	0.82	levofloxacin
gyrA	6733	c.-569G>A	upstream_gene_variant	0.82	moxifloxacin
gyrB	6745	c.1506T>C	synonymous_variant	0.69	levofloxacin	Not assoc w R - Interim
gyrB	6745	c.1506T>C	synonymous_variant	0.69	moxifloxacin	Not assoc w R - Interim
gyrA	6751	c.-551G>C	upstream_gene_variant	0.69	levofloxacin
gyrA	6751	c.-551G>C	upstream_gene_variant	0.69	moxifloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	0.69	levofloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	0.69	moxifloxacin
gyrA	6769	c.-533C>T	upstream_gene_variant	0.69	levofloxacin
gyrA	6769	c.-533C>T	upstream_gene_variant	0.69	moxifloxacin
gyrB	6775	c.1536G>C	synonymous_variant	0.64	levofloxacin	Not assoc w R - Interim
gyrB	6775	c.1536G>C	synonymous_variant	0.64	moxifloxacin	Not assoc w R - Interim
gyrA	6787	c.-515G>A	upstream_gene_variant	0.69	levofloxacin
gyrA	6787	c.-515G>A	upstream_gene_variant	0.69	moxifloxacin
gyrB	6911	p.Asn558His	missense_variant	0.67	levofloxacin
gyrB	6911	p.Asn558His	missense_variant	0.67	moxifloxacin
gyrB	6931	c.1692A>G	synonymous_variant	0.73	levofloxacin	Not assoc w R - Interim
gyrB	6931	c.1692A>G	synonymous_variant	0.73	moxifloxacin	Not assoc w R - Interim
gyrA	6934	c.-368A>G	upstream_gene_variant	0.73	levofloxacin
gyrA	6934	c.-368A>G	upstream_gene_variant	0.73	moxifloxacin
gyrA	6949	c.-353A>G	upstream_gene_variant	0.69	levofloxacin
gyrA	6949	c.-353A>G	upstream_gene_variant	0.69	moxifloxacin
gyrA	6955	c.-347G>A	upstream_gene_variant	0.69	levofloxacin
gyrA	6955	c.-347G>A	upstream_gene_variant	0.69	moxifloxacin
gyrA	6967	c.-335T>C	upstream_gene_variant	0.69	levofloxacin
gyrA	6967	c.-335T>C	upstream_gene_variant	0.69	moxifloxacin
gyrA	6970	c.-332C>T	upstream_gene_variant	0.69	levofloxacin
gyrA	6970	c.-332C>T	upstream_gene_variant	0.69	moxifloxacin
gyrA	6976	c.-326A>G	upstream_gene_variant	0.69	levofloxacin
gyrA	6976	c.-326A>G	upstream_gene_variant	0.69	moxifloxacin
gyrA	6982	c.-320A>C	upstream_gene_variant	0.69	levofloxacin
gyrA	6982	c.-320A>C	upstream_gene_variant	0.69	moxifloxacin
gyrA	6985	c.-317C>T	upstream_gene_variant	0.67	levofloxacin
gyrA	6985	c.-317C>T	upstream_gene_variant	0.67	moxifloxacin
gyrA	6994	c.-308C>G	upstream_gene_variant	0.69	levofloxacin
gyrA	6994	c.-308C>G	upstream_gene_variant	0.69	moxifloxacin
gyrA	6997	c.-305G>A	upstream_gene_variant	0.69	levofloxacin
gyrA	6997	c.-305G>A	upstream_gene_variant	0.69	moxifloxacin
gyrA	7000	c.-302C>T	upstream_gene_variant	0.69	levofloxacin
gyrA	7000	c.-302C>T	upstream_gene_variant	0.69	moxifloxacin
gyrA	7003	c.-299C>T	upstream_gene_variant	0.69	levofloxacin
gyrA	7003	c.-299C>T	upstream_gene_variant	0.69	moxifloxacin
gyrA	7006	c.-296T>G	upstream_gene_variant	0.69	levofloxacin
gyrA	7006	c.-296T>G	upstream_gene_variant	0.69	moxifloxacin
gyrA	7007	c.-295C>T	upstream_gene_variant	0.69	levofloxacin
gyrA	7007	c.-295C>T	upstream_gene_variant	0.69	moxifloxacin
gyrB	7023	p.Leu595Gln	missense_variant	0.79	levofloxacin
gyrB	7023	p.Leu595Gln	missense_variant	0.79	moxifloxacin
gyrA	7484	c.183T>C	synonymous_variant	0.91	levofloxacin
gyrA	7484	c.183T>C	synonymous_variant	0.91	moxifloxacin
gyrA	7490	c.189C>G	synonymous_variant	1.0	levofloxacin
gyrA	7490	c.189C>G	synonymous_variant	1.0	moxifloxacin
gyrA	7502	c.201C>T	synonymous_variant	0.92	levofloxacin
gyrA	7502	c.201C>T	synonymous_variant	0.92	moxifloxacin
gyrA	7526	c.225G>T	synonymous_variant	0.92	levofloxacin	Not assoc w R - Interim
gyrA	7526	c.225G>T	synonymous_variant	0.92	moxifloxacin	Not assoc w R - Interim
gyrA	7532	c.231T>C	synonymous_variant	0.92	levofloxacin	Not assoc w R - Interim
gyrA	7532	c.231T>C	synonymous_variant	0.92	moxifloxacin	Not assoc w R - Interim
gyrA	7541	c.240C>G	synonymous_variant	0.83	levofloxacin	Not assoc w R - Interim
gyrA	7541	c.240C>G	synonymous_variant	0.83	moxifloxacin	Not assoc w R - Interim
gyrA	7547	c.246C>T	synonymous_variant	0.75	levofloxacin	Not assoc w R - Interim
gyrA	7547	c.246C>T	synonymous_variant	0.75	moxifloxacin	Not assoc w R - Interim
gyrA	8531	c.1230G>T	synonymous_variant	0.9	levofloxacin	Not assoc w R - Interim
gyrA	8531	c.1230G>T	synonymous_variant	0.9	moxifloxacin	Not assoc w R - Interim
gyrA	8535	p.Glu412Gln	missense_variant	0.88	levofloxacin
gyrA	8535	p.Glu412Gln	missense_variant	0.88	moxifloxacin
gyrA	8543	c.1242C>T	synonymous_variant	0.9	levofloxacin
gyrA	8543	c.1242C>T	synonymous_variant	0.9	moxifloxacin
gyrA	8546	c.1245T>C	synonymous_variant	0.9	levofloxacin	Not assoc w R - Interim
gyrA	8546	c.1245T>C	synonymous_variant	0.9	moxifloxacin	Not assoc w R - Interim
gyrA	8555	c.1254G>C	synonymous_variant	0.91	levofloxacin
gyrA	8555	c.1254G>C	synonymous_variant	0.91	moxifloxacin
gyrA	8561	c.1260A>C	synonymous_variant	0.91	levofloxacin	Not assoc w R - Interim
gyrA	8561	c.1260A>C	synonymous_variant	0.91	moxifloxacin	Not assoc w R - Interim
gyrA	8585	c.1284C>T	synonymous_variant	0.92	levofloxacin
gyrA	8585	c.1284C>T	synonymous_variant	0.92	moxifloxacin
gyrA	8588	c.1287G>A	synonymous_variant	0.92	levofloxacin
gyrA	8588	c.1287G>A	synonymous_variant	0.92	moxifloxacin
gyrA	8619	c.1318T>C	synonymous_variant	0.9	levofloxacin	Not assoc w R - Interim
gyrA	8619	c.1318T>C	synonymous_variant	0.9	moxifloxacin	Not assoc w R - Interim
gyrA	8624	c.1323G>T	synonymous_variant	0.9	levofloxacin	Not assoc w R - Interim
gyrA	8624	c.1323G>T	synonymous_variant	0.9	moxifloxacin	Not assoc w R - Interim
gyrA	8627	c.1326C>A	synonymous_variant	0.9	levofloxacin
gyrA	8627	c.1326C>A	synonymous_variant	0.9	moxifloxacin
gyrA	8636	c.1335A>C	synonymous_variant	0.9	levofloxacin	Not assoc w R - Interim
gyrA	8636	c.1335A>C	synonymous_variant	0.9	moxifloxacin	Not assoc w R - Interim
gyrA	8642	c.1341A>G	synonymous_variant	0.9	levofloxacin
gyrA	8642	c.1341A>G	synonymous_variant	0.9	moxifloxacin
gyrA	8655	p.Ile452Val	missense_variant	0.92	levofloxacin
gyrA	8655	p.Ile452Val	missense_variant	0.92	moxifloxacin
gyrA	8672	c.1371A>G	synonymous_variant	0.91	levofloxacin	Not assoc w R - Interim
gyrA	8672	c.1371A>G	synonymous_variant	0.91	moxifloxacin	Not assoc w R - Interim
gyrA	8678	c.1377G>A	synonymous_variant	0.9	levofloxacin
gyrA	8678	c.1377G>A	synonymous_variant	0.9	moxifloxacin
gyrA	8694	c.1393C>T	synonymous_variant	0.96	levofloxacin	Not assoc w R - Interim
gyrA	8694	c.1393C>T	synonymous_variant	0.96	moxifloxacin	Not assoc w R - Interim
gyrA	8711	c.1410A>C	synonymous_variant	0.92	levofloxacin
gyrA	8711	c.1410A>C	synonymous_variant	0.92	moxifloxacin
gyrA	8714	c.1413A>G	synonymous_variant	0.88	levofloxacin
gyrA	8714	c.1413A>G	synonymous_variant	0.88	moxifloxacin
gyrA	8717	c.1416C>G	synonymous_variant	0.88	levofloxacin	Not assoc w R - Interim
gyrA	8717	c.1416C>G	synonymous_variant	0.88	moxifloxacin	Not assoc w R - Interim
gyrA	8720	c.1419G>A	synonymous_variant	0.88	levofloxacin
gyrA	8720	c.1419G>A	synonymous_variant	0.88	moxifloxacin
gyrA	8729	c.1428T>C	synonymous_variant	0.88	levofloxacin
gyrA	8729	c.1428T>C	synonymous_variant	0.88	moxifloxacin
gyrA	8747	c.1446A>G	synonymous_variant	0.89	levofloxacin
gyrA	8747	c.1446A>G	synonymous_variant	0.89	moxifloxacin
gyrA	8765	p.Asp488Glu	missense_variant	0.93	levofloxacin	Uncertain significance
gyrA	8765	p.Asp488Glu	missense_variant	0.93	moxifloxacin	Uncertain significance
gyrA	8767	p.Arg489Lys	missense_variant	0.93	levofloxacin	Uncertain significance
gyrA	8767	p.Arg489Lys	missense_variant	0.93	moxifloxacin	Uncertain significance
gyrA	8779	p.Asp493Ala	missense_variant	0.92	levofloxacin
gyrA	8779	p.Asp493Ala	missense_variant	0.92	moxifloxacin
gyrA	8786	c.1485T>C	synonymous_variant	0.92	levofloxacin
gyrA	8786	c.1485T>C	synonymous_variant	0.92	moxifloxacin
gyrA	8789	c.1488C>T	synonymous_variant	0.92	levofloxacin
gyrA	8789	c.1488C>T	synonymous_variant	0.92	moxifloxacin
gyrA	8792	c.1491G>C	synonymous_variant	0.92	levofloxacin
gyrA	8792	c.1491G>C	synonymous_variant	0.92	moxifloxacin
gyrA	8798	c.1497C>T	synonymous_variant	0.92	levofloxacin	Not assoc w R - Interim
gyrA	8798	c.1497C>T	synonymous_variant	0.92	moxifloxacin	Not assoc w R - Interim
gyrA	8810	c.1509A>C	synonymous_variant	0.87	levofloxacin
gyrA	8810	c.1509A>C	synonymous_variant	0.87	moxifloxacin
gyrA	8813	p.Asp504Glu	missense_variant	0.87	levofloxacin	Uncertain significance
gyrA	8813	p.Asp504Glu	missense_variant	0.87	moxifloxacin	Uncertain significance
gyrA	8818	p.Ser506Asn	missense_variant	0.87	levofloxacin	Uncertain significance
gyrA	8818	p.Ser506Asn	missense_variant	0.87	moxifloxacin	Uncertain significance
gyrA	8829	c.1528T>C	synonymous_variant	0.86	levofloxacin	Not assoc w R - Interim
gyrA	8829	c.1528T>C	synonymous_variant	0.86	moxifloxacin	Not assoc w R - Interim
gyrA	8840	c.1539C>G	synonymous_variant	0.87	levofloxacin
gyrA	8840	c.1539C>G	synonymous_variant	0.87	moxifloxacin
gyrA	8852	c.1551T>C	synonymous_variant	0.9	levofloxacin
gyrA	8852	c.1551T>C	synonymous_variant	0.9	moxifloxacin
gyrA	8858	c.1557T>G	synonymous_variant	0.9	levofloxacin	Not assoc w R - Interim
gyrA	8858	c.1557T>G	synonymous_variant	0.9	moxifloxacin	Not assoc w R - Interim
gyrA	8870	c.1569G>C	synonymous_variant	0.94	levofloxacin	Not assoc w R - Interim
gyrA	8870	c.1569G>C	synonymous_variant	0.94	moxifloxacin	Not assoc w R - Interim
gyrA	8873	c.1572A>T	synonymous_variant	0.94	levofloxacin
gyrA	8873	c.1572A>T	synonymous_variant	0.94	moxifloxacin
gyrA	8888	c.1587C>G	synonymous_variant	0.94	levofloxacin
gyrA	8888	c.1587C>G	synonymous_variant	0.94	moxifloxacin
gyrA	8897	c.1596T>C	synonymous_variant	0.93	levofloxacin	Not assoc w R - Interim
gyrA	8897	c.1596T>C	synonymous_variant	0.93	moxifloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.93	levofloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.93	moxifloxacin	Not assoc w R - Interim
gyrA	8915	c.1614A>G	synonymous_variant	0.86	levofloxacin	Not assoc w R - Interim
gyrA	8915	c.1614A>G	synonymous_variant	0.86	moxifloxacin	Not assoc w R - Interim
gyrA	8924	c.1623C>T	synonymous_variant	0.9	levofloxacin
gyrA	8924	c.1623C>T	synonymous_variant	0.9	moxifloxacin
gyrA	8930	c.1629C>G	synonymous_variant	0.9	levofloxacin	Not assoc w R - Interim
gyrA	8930	c.1629C>G	synonymous_variant	0.9	moxifloxacin
gyrA	8933	c.1632G>C	synonymous_variant	0.9	levofloxacin
gyrA	8933	c.1632G>C	synonymous_variant	0.9	moxifloxacin
gyrA	8936	c.1635G>A	synonymous_variant	0.9	levofloxacin
gyrA	8936	c.1635G>A	synonymous_variant	0.9	moxifloxacin
gyrA	8939	c.1638T>C	synonymous_variant	0.9	levofloxacin
gyrA	8939	c.1638T>C	synonymous_variant	0.9	moxifloxacin
gyrA	8942	c.1641G>C	synonymous_variant	0.9	levofloxacin
gyrA	8942	c.1641G>C	synonymous_variant	0.9	moxifloxacin
gyrA	8946	c.1645_1647delTTGinsCTC	synonymous_variant	0.9	levofloxacin	Not assoc w R - Interim
gyrA	8946	c.1645_1647delTTGinsCTC	synonymous_variant	0.9	moxifloxacin	Not assoc w R - Interim
gyrA	8983	p.Cys561Ser	missense_variant	0.92	levofloxacin
gyrA	8983	p.Cys561Ser	missense_variant	0.92	moxifloxacin
gyrA	8987	c.1686C>G	synonymous_variant	0.92	levofloxacin
gyrA	8987	c.1686C>G	synonymous_variant	0.92	moxifloxacin
gyrA	8990	c.1689C>G	synonymous_variant	0.92	levofloxacin
gyrA	8990	c.1689C>G	synonymous_variant	0.92	moxifloxacin
gyrA	8996	c.1695T>C	synonymous_variant	0.9	levofloxacin
gyrA	8996	c.1695T>C	synonymous_variant	0.9	moxifloxacin
gyrA	8998	p.Leu566Trp	missense_variant	0.91	levofloxacin	Uncertain significance
gyrA	8998	p.Leu566Trp	missense_variant	0.91	moxifloxacin	Uncertain significance
gyrA	9003	c.1702C>T	synonymous_variant	0.91	levofloxacin
gyrA	9003	c.1702C>T	synonymous_variant	0.91	moxifloxacin
gyrA	9023	c.1722A>C	synonymous_variant	0.88	levofloxacin	Not assoc w R - Interim
gyrA	9023	c.1722A>C	synonymous_variant	0.88	moxifloxacin	Not assoc w R - Interim
gyrA	9029	c.1728T>A	synonymous_variant	0.86	levofloxacin
gyrA	9029	c.1728T>A	synonymous_variant	0.86	moxifloxacin
gyrA	9032	c.1731T>C	synonymous_variant	0.85	levofloxacin
gyrA	9032	c.1731T>C	synonymous_variant	0.85	moxifloxacin
gyrA	9035	c.1734G>C	synonymous_variant	0.85	levofloxacin	Not assoc w R - Interim
gyrA	9035	c.1734G>C	synonymous_variant	0.85	moxifloxacin
gyrA	9038	c.1737C>G	synonymous_variant	0.85	levofloxacin
gyrA	9038	c.1737C>G	synonymous_variant	0.85	moxifloxacin
gyrA	9050	p.Asp583Glu	missense_variant	0.85	levofloxacin	Uncertain significance
gyrA	9050	p.Asp583Glu	missense_variant	0.85	moxifloxacin	Uncertain significance
gyrA	9051	c.1750T>C	synonymous_variant	0.85	levofloxacin
gyrA	9051	c.1750T>C	synonymous_variant	0.85	moxifloxacin
gyrA	9062	c.1761C>A	synonymous_variant	0.91	levofloxacin
gyrA	9062	c.1761C>A	synonymous_variant	0.91	moxifloxacin
gyrA	9074	c.1773G>C	synonymous_variant	0.92	levofloxacin
gyrA	9074	c.1773G>C	synonymous_variant	0.92	moxifloxacin
gyrA	9080	c.1779G>T	synonymous_variant	0.93	levofloxacin
gyrA	9080	c.1779G>T	synonymous_variant	0.93	moxifloxacin
gyrA	9089	c.1788G>C	synonymous_variant	0.94	levofloxacin
gyrA	9089	c.1788G>C	synonymous_variant	0.94	moxifloxacin
gyrA	9101	c.1800A>G	synonymous_variant	0.94	levofloxacin	Not assoc w R - Interim
gyrA	9101	c.1800A>G	synonymous_variant	0.94	moxifloxacin	Not assoc w R - Interim
gyrA	9104	c.1803C>A	synonymous_variant	0.94	levofloxacin
gyrA	9104	c.1803C>A	synonymous_variant	0.94	moxifloxacin
gyrA	9110	c.1809G>A	synonymous_variant	0.95	levofloxacin	Not assoc w R - Interim
gyrA	9110	c.1809G>A	synonymous_variant	0.95	moxifloxacin	Not assoc w R - Interim
gyrA	9128	c.1827C>A	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9128	c.1827C>A	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9143	c.1842T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9147	p.Gly616Ser	missense_variant	0.95	levofloxacin
gyrA	9147	p.Gly616Ser	missense_variant	0.95	moxifloxacin
gyrA	9153	p.Thr618Glu	missense_variant	1.0	levofloxacin
gyrA	9153	p.Thr618Glu	missense_variant	1.0	moxifloxacin
gyrA	9161	c.1860C>G	synonymous_variant	1.0	levofloxacin
gyrA	9161	c.1860C>G	synonymous_variant	1.0	moxifloxacin
gyrA	9164	c.1863G>C	synonymous_variant	1.0	levofloxacin
gyrA	9164	c.1863G>C	synonymous_variant	1.0	moxifloxacin
gyrA	9167	c.1866C>T	synonymous_variant	1.0	levofloxacin
gyrA	9167	c.1866C>T	synonymous_variant	1.0	moxifloxacin
gyrA	9182	c.1881T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9182	c.1881T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9183	p.Arg628Lys	missense_variant	1.0	levofloxacin
gyrA	9183	p.Arg628Lys	missense_variant	1.0	moxifloxacin
gyrA	9197	c.1896G>C	synonymous_variant	1.0	levofloxacin
gyrA	9197	c.1896G>C	synonymous_variant	1.0	moxifloxacin
gyrA	9230	c.1929T>C	synonymous_variant	0.98	levofloxacin
gyrA	9230	c.1929T>C	synonymous_variant	0.98	moxifloxacin
gyrA	9236	c.1935G>C	synonymous_variant	0.98	levofloxacin
gyrA	9236	c.1935G>C	synonymous_variant	0.98	moxifloxacin
gyrA	9242	c.1941A>C	synonymous_variant	0.98	levofloxacin
gyrA	9242	c.1941A>C	synonymous_variant	0.98	moxifloxacin
gyrA	9248	c.1947G>C	synonymous_variant	0.98	levofloxacin
gyrA	9248	c.1947G>C	synonymous_variant	0.98	moxifloxacin
gyrA	9252	p.Val651Ile	missense_variant	0.98	levofloxacin	Uncertain significance
gyrA	9252	p.Val651Ile	missense_variant	0.98	moxifloxacin	Uncertain significance
gyrA	9266	c.1965C>T	synonymous_variant	0.98	levofloxacin
gyrA	9266	c.1965C>T	synonymous_variant	0.98	moxifloxacin
gyrA	9284	c.1983T>C	synonymous_variant	0.98	levofloxacin
gyrA	9284	c.1983T>C	synonymous_variant	0.98	moxifloxacin
gyrA	9287	c.1986G>C	synonymous_variant	0.95	levofloxacin
gyrA	9287	c.1986G>C	synonymous_variant	0.95	moxifloxacin
gyrA	9291	c.1990C>T	synonymous_variant	0.98	levofloxacin
gyrA	9291	c.1990C>T	synonymous_variant	0.98	moxifloxacin
gyrA	9296	c.1995T>C	synonymous_variant	0.98	levofloxacin	Not assoc w R - Interim
gyrA	9296	c.1995T>C	synonymous_variant	0.98	moxifloxacin	Not assoc w R - Interim
gyrA	9304	p.Gly668Glu	missense_variant	1.0	levofloxacin
gyrA	9304	p.Gly668Glu	missense_variant	1.0	moxifloxacin
gyrA	9308	p.Asp669Glu	missense_variant	0.98	levofloxacin
gyrA	9308	p.Asp669Glu	missense_variant	0.98	moxifloxacin
gyrA	9315	c.2014C>T	synonymous_variant	0.98	levofloxacin	Not assoc w R - Interim
gyrA	9315	c.2014C>T	synonymous_variant	0.98	moxifloxacin	Not assoc w R - Interim
gyrA	9326	c.2025G>T	synonymous_variant	0.95	levofloxacin
gyrA	9326	c.2025G>T	synonymous_variant	0.95	moxifloxacin
gyrA	9338	c.2037G>A	synonymous_variant	0.94	levofloxacin
gyrA	9338	c.2037G>A	synonymous_variant	0.94	moxifloxacin
gyrA	9341	c.2040C>G	synonymous_variant	0.94	levofloxacin
gyrA	9341	c.2040C>G	synonymous_variant	0.94	moxifloxacin
gyrA	9345	c.2044A>C	synonymous_variant	0.94	levofloxacin
gyrA	9345	c.2044A>C	synonymous_variant	0.94	moxifloxacin
gyrA	9383	c.2082T>C	synonymous_variant	0.94	levofloxacin
gyrA	9383	c.2082T>C	synonymous_variant	0.94	moxifloxacin
gyrA	9386	c.2085T>C	synonymous_variant	0.94	levofloxacin	Not assoc w R - Interim
gyrA	9386	c.2085T>C	synonymous_variant	0.94	moxifloxacin	Not assoc w R - Interim
gyrA	9395	c.2094G>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9395	c.2094G>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9398	c.2097T>C	synonymous_variant	0.8	levofloxacin
gyrA	9398	c.2097T>C	synonymous_variant	0.8	moxifloxacin
mshA	574607	c.-741G>A	upstream_gene_variant	0.87	isoniazid
mshA	574607	c.-741G>A	upstream_gene_variant	0.87	ethionamide
mshA	574610	c.-738G>A	upstream_gene_variant	0.88	isoniazid
mshA	574610	c.-738G>A	upstream_gene_variant	0.88	ethionamide
mshA	574616	c.-732G>C	upstream_gene_variant	0.9	isoniazid
mshA	574616	c.-732G>C	upstream_gene_variant	0.9	ethionamide
mshA	574640	c.-708G>A	upstream_gene_variant	0.91	isoniazid
mshA	574640	c.-708G>A	upstream_gene_variant	0.91	ethionamide
mshA	574646	c.-702G>A	upstream_gene_variant	0.95	isoniazid
mshA	574646	c.-702G>A	upstream_gene_variant	0.95	ethionamide
mshA	574650	c.-698A>C	upstream_gene_variant	0.95	isoniazid
mshA	574650	c.-698A>C	upstream_gene_variant	0.95	ethionamide
mshA	574667	c.-681G>A	upstream_gene_variant	0.94	isoniazid
mshA	574667	c.-681G>A	upstream_gene_variant	0.94	ethionamide
mshA	574673	c.-675A>G	upstream_gene_variant	0.94	isoniazid
mshA	574673	c.-675A>G	upstream_gene_variant	0.94	ethionamide
mshA	574676	c.-672G>C	upstream_gene_variant	0.94	isoniazid
mshA	574676	c.-672G>C	upstream_gene_variant	0.94	ethionamide
mshA	574683	c.-665T>C	upstream_gene_variant	0.89	isoniazid	Uncertain significance
mshA	574683	c.-665T>C	upstream_gene_variant	0.89	ethionamide
mshA	574688	c.-660G>C	upstream_gene_variant	0.89	isoniazid	Uncertain significance
mshA	574688	c.-660G>C	upstream_gene_variant	0.89	ethionamide	Uncertain significance
mshA	574694	c.-654C>G	upstream_gene_variant	0.89	isoniazid
mshA	574694	c.-654C>G	upstream_gene_variant	0.89	ethionamide
mshA	574712	c.-636A>G	upstream_gene_variant	0.89	isoniazid
mshA	574712	c.-636A>G	upstream_gene_variant	0.89	ethionamide
mshA	574718	c.-630A>G	upstream_gene_variant	0.89	isoniazid
mshA	574718	c.-630A>G	upstream_gene_variant	0.89	ethionamide
mshA	574721	c.-627C>A	upstream_gene_variant	0.89	isoniazid
mshA	574721	c.-627C>A	upstream_gene_variant	0.89	ethionamide
mshA	574724	c.-624T>C	upstream_gene_variant	0.89	isoniazid
mshA	574724	c.-624T>C	upstream_gene_variant	0.89	ethionamide
mshA	574727	c.-621G>C	upstream_gene_variant	0.89	isoniazid
mshA	574727	c.-621G>C	upstream_gene_variant	0.89	ethionamide
mshA	574731	c.-617A>G	upstream_gene_variant	0.89	isoniazid
mshA	574731	c.-617A>G	upstream_gene_variant	0.89	ethionamide
mshA	574739	c.-609T>C	upstream_gene_variant	0.89	isoniazid
mshA	574739	c.-609T>C	upstream_gene_variant	0.89	ethionamide
mshA	575072	c.-276G>C	upstream_gene_variant	0.91	isoniazid
mshA	575072	c.-276G>C	upstream_gene_variant	0.91	ethionamide
mshA	575075	c.-273T>C	upstream_gene_variant	0.91	isoniazid	Uncertain significance
mshA	575075	c.-273T>C	upstream_gene_variant	0.91	ethionamide
mshA	575081	c.-267A>G	upstream_gene_variant	0.91	isoniazid
mshA	575081	c.-267A>G	upstream_gene_variant	0.91	ethionamide
mshA	575087	c.-261C>G	upstream_gene_variant	0.91	isoniazid
mshA	575087	c.-261C>G	upstream_gene_variant	0.91	ethionamide
mshA	575109	c.-239G>T	upstream_gene_variant	0.91	isoniazid
mshA	575109	c.-239G>T	upstream_gene_variant	0.91	ethionamide
mshA	575114	c.-234G>A	upstream_gene_variant	0.83	isoniazid	Uncertain significance
mshA	575114	c.-234G>A	upstream_gene_variant	0.83	ethionamide
mshA	575117	c.-231T>C	upstream_gene_variant	0.83	isoniazid
mshA	575117	c.-231T>C	upstream_gene_variant	0.83	ethionamide
mshA	575118	c.-230A>G	upstream_gene_variant	0.83	isoniazid	Uncertain significance
mshA	575118	c.-230A>G	upstream_gene_variant	0.83	ethionamide
mshA	575123	c.-225A>G	upstream_gene_variant	0.83	isoniazid
mshA	575123	c.-225A>G	upstream_gene_variant	0.83	ethionamide
mshA	575124	c.-224_-222delGGGinsCGT	upstream_gene_variant	0.83	isoniazid
mshA	575124	c.-224_-222delGGGinsCGT	upstream_gene_variant	0.83	ethionamide
mshA	575695	c.348C>G	synonymous_variant	0.83	isoniazid	Not assoc w R - Interim
mshA	575695	c.348C>G	synonymous_variant	0.83	ethionamide
mshA	575704	c.357T>C	synonymous_variant	0.87	isoniazid
mshA	575704	c.357T>C	synonymous_variant	0.87	ethionamide
mshA	575705	c.358T>C	synonymous_variant	0.87	isoniazid
mshA	575705	c.358T>C	synonymous_variant	0.87	ethionamide
mshA	575713	c.366G>A	synonymous_variant	0.88	isoniazid
mshA	575713	c.366G>A	synonymous_variant	0.88	ethionamide
mshA	575719	c.372C>T	synonymous_variant	0.89	isoniazid	Not assoc w R - Interim
mshA	575719	c.372C>T	synonymous_variant	0.89	ethionamide	Not assoc w R - Interim
mshA	575734	c.387T>G	synonymous_variant	0.82	isoniazid
mshA	575734	c.387T>G	synonymous_variant	0.82	ethionamide
mshA	575746	c.399C>G	synonymous_variant	0.82	isoniazid
mshA	575746	c.399C>G	synonymous_variant	0.82	ethionamide
mshA	575767	c.420G>A	synonymous_variant	0.82	isoniazid
mshA	575767	c.420G>A	synonymous_variant	0.82	ethionamide
mshA	575771	p.Val142Ser	missense_variant	0.81	isoniazid
mshA	575771	p.Val142Ser	missense_variant	0.81	ethionamide
mshA	575779	p.Glu144Asp	missense_variant	0.84	isoniazid
mshA	575779	p.Glu144Asp	missense_variant	0.84	ethionamide
mshA	575780	p.Pro145Ala	missense_variant	0.84	isoniazid
mshA	575780	p.Pro145Ala	missense_variant	0.84	ethionamide
mshA	575821	c.474G>C	synonymous_variant	0.76	isoniazid
mshA	575821	c.474G>C	synonymous_variant	0.76	ethionamide
mshA	575824	c.477T>G	synonymous_variant	0.74	isoniazid
mshA	575824	c.477T>G	synonymous_variant	0.74	ethionamide
mshA	575842	c.495G>C	synonymous_variant	0.68	isoniazid
mshA	575842	c.495G>C	synonymous_variant	0.68	ethionamide
mshA	575845	c.498C>G	synonymous_variant	0.65	isoniazid
mshA	575845	c.498C>G	synonymous_variant	0.65	ethionamide
mshA	575848	c.501C>T	synonymous_variant	0.63	isoniazid
mshA	575848	c.501C>T	synonymous_variant	0.63	ethionamide
mshA	575851	c.504C>G	synonymous_variant	0.63	isoniazid
mshA	575851	c.504C>G	synonymous_variant	0.63	ethionamide
mshA	575864	c.517T>C	synonymous_variant	0.56	isoniazid
mshA	575864	c.517T>C	synonymous_variant	0.56	ethionamide
ccsA	619507	c.-384A>G	upstream_gene_variant	0.93	kanamycin
					capreomycin
					amikacin
ccsA	619516	c.-375C>G	upstream_gene_variant	0.92	kanamycin
					capreomycin
					amikacin
ccsA	619525	c.-366C>T	upstream_gene_variant	0.92	kanamycin
					capreomycin
					amikacin
ccsA	619531	c.-360T>C	upstream_gene_variant	0.92	kanamycin
					capreomycin
					amikacin
ccsA	619534	c.-357G>A	upstream_gene_variant	0.92	kanamycin
					capreomycin
					amikacin
ccsA	619537	c.-354A>G	upstream_gene_variant	0.92	kanamycin
					capreomycin
					amikacin
ccsA	619540	c.-351C>G	upstream_gene_variant	0.85	kanamycin
					capreomycin
					amikacin
ccsA	619543	c.-348C>G	upstream_gene_variant	0.85	kanamycin
					capreomycin
					amikacin
ccsA	619544	c.-347A>C	upstream_gene_variant	0.85	kanamycin
					capreomycin
					amikacin
ccsA	619552	c.-339A>G	upstream_gene_variant	0.85	kanamycin
					capreomycin
					amikacin
ccsA	619555	c.-336C>T	upstream_gene_variant	0.85	kanamycin
					capreomycin
					amikacin
ccsA	619561	c.-330G>C	upstream_gene_variant	0.79	kanamycin
					capreomycin
					amikacin
ccsA	619564	c.-327C>G	upstream_gene_variant	0.79	kanamycin
					capreomycin
					amikacin
ccsA	619570	c.-321G>C	upstream_gene_variant	0.79	kanamycin
					capreomycin
					amikacin
ccsA	619573	c.-318G>C	upstream_gene_variant	0.79	kanamycin
					capreomycin
					amikacin
ccsA	619574	c.-317G>A	upstream_gene_variant	0.79	kanamycin
					capreomycin
					amikacin
ccsA	619579	c.-312G>C	upstream_gene_variant	0.73	kanamycin
					capreomycin
					amikacin
ccsA	619588	c.-303C>G	upstream_gene_variant	0.69	kanamycin
					capreomycin
					amikacin
ccsA	619591	c.-300G>C	upstream_gene_variant	0.69	kanamycin
					capreomycin
					amikacin
ccsA	619594	c.-297G>A	upstream_gene_variant	0.69	kanamycin
					capreomycin
					amikacin
ccsA	620197	p.Gln103Met	missense_variant	0.83	kanamycin
					capreomycin
					amikacin
ccsA	620238	c.348G>C	synonymous_variant	0.73	kanamycin
					capreomycin
					amikacin
ccsA	620245	c.355T>C	synonymous_variant	0.69	kanamycin
					capreomycin
					amikacin
ccsA	620249	p.Ser120Cys	missense_variant	0.69	kanamycin
					capreomycin
					amikacin
ccsA	620253	c.363G>C	synonymous_variant	0.69	kanamycin
					capreomycin
					amikacin
ccsA	620254	c.364_366delCTCinsTTG	synonymous_variant	0.69	kanamycin
					capreomycin
					amikacin
ccsA	620271	c.381C>G	synonymous_variant	0.75	kanamycin
					capreomycin
					amikacin
ccsA	620284	p.Ala132Pro	missense_variant	0.75	kanamycin
					capreomycin
					amikacin
ccsA	620288	p.Arg133Gln	missense_variant	0.75	kanamycin
					capreomycin
					amikacin
ccsA	620291	p.Tyr134Phe	missense_variant	0.75	kanamycin
					capreomycin
					amikacin
ccsA	620307	c.417C>G	synonymous_variant	0.75	kanamycin
					capreomycin
					amikacin
ccsA	620317	p.Val143Leu	missense_variant	0.73	kanamycin
					capreomycin
					amikacin
ccsA	620325	c.435G>C	synonymous_variant	0.75	kanamycin
					capreomycin
					amikacin
ccsA	620343	c.453G>C	synonymous_variant	0.77	kanamycin
					capreomycin
					amikacin
ccsA	620349	c.459A>T	synonymous_variant	0.83	kanamycin
					capreomycin
					amikacin
ccsA	620362	p.Ala158Thr	missense_variant	0.9	kanamycin
					capreomycin
					amikacin
ccsA	620367	c.477T>C	synonymous_variant	0.9	kanamycin
					capreomycin
					amikacin
ccsA	620625	c.735A>C	synonymous_variant	0.8	kanamycin
					capreomycin
					amikacin
ccsA	620631	c.741T>G	synonymous_variant	0.8	kanamycin
					capreomycin
					amikacin
ccsA	620649	c.759A>G	synonymous_variant	0.8	kanamycin
					capreomycin
					amikacin
ccsA	620652	c.762C>G	synonymous_variant	0.82	kanamycin
					capreomycin
					amikacin
ccsA	620661	c.771C>G	synonymous_variant	0.89	kanamycin
					capreomycin
					amikacin
ccsA	620685	c.795G>A	synonymous_variant	0.85	kanamycin	Not assoc w R - Interim
					capreomycin	Not assoc w R - Interim
					amikacin
ccsA	620698	p.Val270Ile	missense_variant	0.87	kanamycin
					capreomycin
					amikacin
ccsA	620712	c.822G>C	synonymous_variant	0.86	kanamycin
					capreomycin
					amikacin
ccsA	620715	c.825C>T	synonymous_variant	0.88	kanamycin
					capreomycin
					amikacin
ccsA	620721	c.831G>A	synonymous_variant	0.89	kanamycin
					capreomycin
					amikacin
ccsA	620733	c.843G>C	synonymous_variant	0.92	kanamycin
					capreomycin
					amikacin
ccsA	620739	c.849A>G	synonymous_variant	0.92	kanamycin
					capreomycin
					amikacin
ccsA	620742	c.852G>C	synonymous_variant	0.92	kanamycin
					capreomycin
					amikacin
ccsA	620748	c.858T>C	synonymous_variant	0.91	kanamycin
					capreomycin
					amikacin
ccsA	620778	c.888T>C	synonymous_variant	0.89	kanamycin
					capreomycin
					amikacin
ccsA	620781	c.891C>G	synonymous_variant	0.89	kanamycin
					capreomycin
					amikacin
ccsA	620783	p.Ala298Val	missense_variant	0.89	kanamycin
					capreomycin
					amikacin
ccsA	620787	c.897C>A	synonymous_variant	0.89	kanamycin
					capreomycin
					amikacin
ccsA	620796	c.906C>G	synonymous_variant	0.91	kanamycin
					capreomycin
					amikacin
ccsA	620829	c.939G>C	synonymous_variant	0.9	kanamycin
					capreomycin
					amikacin
ccsA	620835	c.945C>G	synonymous_variant	0.89	kanamycin
					capreomycin
					amikacin
ccsA	620844	c.954C>T	synonymous_variant	0.87	kanamycin
					capreomycin
					amikacin
ccsA	620853	c.963G>C	synonymous_variant	0.79	kanamycin	Not assoc w R - Interim
					capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv0565c	657183	c.288G>A	synonymous_variant	0.83	ethionamide
Rv0565c	657189	c.282C>A	synonymous_variant	0.83	ethionamide
Rv0565c	657193	p.Met93Thr	missense_variant	0.83	ethionamide
Rv0565c	657196	p.Asp92Ala	missense_variant	0.83	ethionamide
Rv0565c	657200	p.Thr91Ala	missense_variant	0.83	ethionamide	Uncertain significance
Rv0565c	657210	c.261C>T	synonymous_variant	0.83	ethionamide	Not assoc w R - Interim
Rv0565c	657213	c.258C>T	synonymous_variant	0.83	ethionamide
Rv0565c	657219	p.Ala84Val	missense_variant	0.92	ethionamide
Rv0565c	657233	p.Ile80Val	missense_variant	0.92	ethionamide
Rv0565c	657240	p.Glu77Lys	missense_variant	0.92	ethionamide
Rv0565c	657252	c.219G>C	synonymous_variant	1.0	ethionamide
Rv0565c	657255	c.216G>A	synonymous_variant	1.0	ethionamide
Rv0565c	657259	p.Tyr71Phe	missense_variant	1.0	ethionamide
Rv0565c	657294	c.177C>A	synonymous_variant	1.0	ethionamide
Rv0565c	657306	c.165C>T	synonymous_variant	1.0	ethionamide
Rv0565c	657312	c.159C>T	synonymous_variant	1.0	ethionamide
Rv0565c	657318	c.153T>C	synonymous_variant	1.0	ethionamide
hadA	731686	c.-244_-243insATGT	upstream_gene_variant	0.88	isoniazid
hadA	731689	c.-240_-237delAGAC	upstream_gene_variant	0.88	isoniazid
hadA	731695	c.-235C>T	upstream_gene_variant	0.88	isoniazid
hadA	731698	c.-232T>G	upstream_gene_variant	0.85	isoniazid
hadA	731708	c.-222G>A	upstream_gene_variant	0.88	isoniazid
hadA	731711	c.-219T>C	upstream_gene_variant	0.89	isoniazid
hadA	731726	c.-204C>G	upstream_gene_variant	0.89	isoniazid
hadA	731729	c.-201C>T	upstream_gene_variant	0.9	isoniazid
hadA	731753	c.-177A>C	upstream_gene_variant	0.88	isoniazid
hadA	731756	c.-174C>T	upstream_gene_variant	0.88	isoniazid
hadA	731774	c.-156T>C	upstream_gene_variant	0.91	isoniazid
hadA	731786	c.-144C>G	upstream_gene_variant	0.89	isoniazid
hadA	731789	c.-141A>G	upstream_gene_variant	0.87	isoniazid
hadA	732396	p.Gly156Ala	missense_variant	0.9	isoniazid
hadA	732398	p.Ala157Thr	missense_variant	0.9	isoniazid
nusG	734111	c.-143A>G	upstream_gene_variant	0.82	rifampicin
nusG	734114	c.-140A>G	upstream_gene_variant	0.83	rifampicin
nusG	734120	c.-134T>C	upstream_gene_variant	0.83	rifampicin	Uncertain significance
nusG	734129	c.-125G>C	upstream_gene_variant	0.91	rifampicin
nusG	734142	c.-112_-110delGCGinsATA	upstream_gene_variant	0.91	rifampicin
nusG	734147	c.-107T>C	upstream_gene_variant	0.91	rifampicin
nusG	734150	c.-104G>C	upstream_gene_variant	0.91	rifampicin
nusG	734153	c.-101C>A	upstream_gene_variant	0.91	rifampicin
nusG	734171	c.-83_-82insG	upstream_gene_variant	0.85	rifampicin
nusG	734175	c.-79G>T	upstream_gene_variant	0.85	rifampicin
nusG	734177	c.-76delG	upstream_gene_variant	0.92	rifampicin
nusG	734183	c.-71C>T	upstream_gene_variant	0.92	rifampicin
nusG	734186	c.-68G>C	upstream_gene_variant	0.92	rifampicin	Uncertain significance
nusG	734403	c.150C>T	synonymous_variant	1.0	rifampicin
nusG	734407	p.Val52Ile	missense_variant	1.0	rifampicin
nusG	734421	c.168A>C	synonymous_variant	1.0	rifampicin
nusG	734424	c.171G>C	synonymous_variant	1.0	rifampicin
nusG	734439	c.186C>G	synonymous_variant	1.0	rifampicin
nusG	734451	c.198G>C	synonymous_variant	1.0	rifampicin
nusG	734454	c.201A>G	synonymous_variant	1.0	rifampicin
nusG	734472	c.219T>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
nusG	734475	c.222T>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
nusG	734478	c.225C>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
nusG	734499	c.246G>C	synonymous_variant	0.94	rifampicin
nusG	734520	c.267C>A	synonymous_variant	0.88	rifampicin
rpoB	760056	c.250_252delCTCinsTTG	synonymous_variant	1.0	rifampicin
rpoB	760070	c.264T>G	synonymous_variant	1.0	rifampicin
rpoB	760091	c.285G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760101	c.295T>C	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoB	760181	c.375T>A	synonymous_variant	0.95	rifampicin
rpoB	760184	c.378A>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoB	760235	c.429T>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	760244	c.438G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	760830	c.1024T>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	760841	c.1035T>C	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoB	760845	p.Thr347Pro	missense_variant	0.9	rifampicin
rpoB	760856	c.1050C>G	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	760916	c.1110C>G	synonymous_variant	0.95	rifampicin
rpoB	760919	c.1113C>G	synonymous_variant	0.96	rifampicin
rpoB	760925	c.1119T>C	synonymous_variant	0.96	rifampicin
rpoB	760928	c.1122G>C	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoB	760931	c.1125C>G	synonymous_variant	0.96	rifampicin
rpoB	760937	c.1131G>A	synonymous_variant	0.96	rifampicin
rpoB	760946	c.1140A>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoB	760973	c.1167G>C	synonymous_variant	0.97	rifampicin
rpoB	760982	c.1176G>T	synonymous_variant	1.0	rifampicin
rpoB	760985	c.1179G>T	synonymous_variant	0.97	rifampicin
rpoB	760991	c.1185G>T	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoB	761006	c.1200C>T	synonymous_variant	0.96	rifampicin
rpoB	761015	c.1209G>C	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoB	761021	c.1215G>C	synonymous_variant	0.9	rifampicin
rpoB	761027	c.1221A>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoB	761036	c.1230G>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	761037	c.1231T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	761051	c.1245G>T	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761057	c.1251G>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761060	c.1254C>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761063	c.1257C>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761558	c.1752C>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	761570	c.1764T>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	761573	c.1767C>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	761579	c.1773G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	761606	c.1800C>G	synonymous_variant	0.86	rifampicin
rpoB	761612	c.1806G>T	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	761615	c.1809A>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	761636	c.1830G>T	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	761645	c.1839C>A	synonymous_variant	0.83	rifampicin
rpoB	761648	c.1842T>C	synonymous_variant	0.82	rifampicin
rpoB	761666	c.1860G>C	synonymous_variant	0.73	rifampicin
rpoB	761690	c.1884G>C	synonymous_variant	0.77	rifampicin
rpoB	761750	c.1944G>C	synonymous_variant	0.89	rifampicin
rpoB	761765	c.1959T>C	synonymous_variant	0.95	rifampicin
rpoB	761772	p.His656Ala	missense_variant	0.95	rifampicin
rpoB	761778	p.Asn658Asp	missense_variant	0.95	rifampicin
rpoB	761791	p.Arg662His	missense_variant	0.95	rifampicin
rpoB	761813	c.2007T>C	synonymous_variant	0.92	rifampicin
rpoB	761828	c.2022C>T	synonymous_variant	0.92	rifampicin
rpoB	761834	c.2028T>C	synonymous_variant	0.91	rifampicin
rpoB	761837	c.2031C>T	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoB	761848	p.Cys681Ser	missense_variant	0.89	rifampicin
rpoB	761852	c.2046C>G	synonymous_variant	0.9	rifampicin
rpoB	761858	c.2052G>C	synonymous_variant	0.91	rifampicin
rpoB	761873	c.2067A>C	synonymous_variant	0.92	rifampicin
rpoB	761885	c.2079T>C	synonymous_variant	0.95	rifampicin
rpoB	761891	c.2085G>C	synonymous_variant	0.95	rifampicin
rpoB	761909	c.2103T>C	synonymous_variant	0.9	rifampicin
rpoB	761912	c.2106T>C	synonymous_variant	0.9	rifampicin
rpoB	761913	p.Asp703Gln	missense_variant	0.9	rifampicin
rpoB	761916	p.Asp704Asn	missense_variant	0.9	rifampicin
rpoB	761921	c.2115C>T	synonymous_variant	0.9	rifampicin
rpoB	761930	c.2124G>C	synonymous_variant	0.9	rifampicin
rpoB	761954	c.2148C>G	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoB	762008	c.2202C>G	synonymous_variant	0.94	rifampicin
rpoB	762014	c.2208C>T	synonymous_variant	0.94	rifampicin
rpoB	762047	c.2241G>A	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoB	762053	c.2247T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762062	c.2256T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762065	c.2259T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762083	c.2277T>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	762086	c.2280G>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	762101	c.2295C>G	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoB	762114	p.Ile770Val	missense_variant	0.92	rifampicin	Uncertain significance
rpoB	762131	c.2325C>G	synonymous_variant	0.92	rifampicin
rpoB	762134	c.2328C>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	762143	c.2337T>C	synonymous_variant	0.93	rifampicin
rpoB	762167	c.2361T>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	762185	c.2379G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	762233	c.2427G>T	synonymous_variant	0.85	rifampicin
rpoB	762254	c.2448T>G	synonymous_variant	0.9	rifampicin
rpoB	762257	c.2451C>G	synonymous_variant	0.89	rifampicin
rpoB	762266	c.2460T>C	synonymous_variant	0.88	rifampicin
rpoB	762281	c.2475G>A	synonymous_variant	0.8	rifampicin
rpoB	762284	c.2478G>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	762293	c.2487T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	762317	c.2511A>G	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoB	762338	c.2532T>C	synonymous_variant	0.82	rifampicin
rpoB	762341	c.2535G>C	synonymous_variant	0.82	rifampicin
rpoB	762347	c.2541T>C	synonymous_variant	0.89	rifampicin
rpoB	762362	p.Glu852Asp	missense_variant	0.89	rifampicin
rpoB	762369	c.2563T>C	synonymous_variant	0.89	rifampicin
rpoC	762395	c.-975G>C	upstream_gene_variant	0.88	rifampicin
rpoC	762398	c.-972T>C	upstream_gene_variant	0.88	rifampicin
rpoC	762401	c.-969G>C	upstream_gene_variant	0.88	rifampicin
rpoB	762404	c.2598T>C	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	762410	c.-960T>C	upstream_gene_variant	0.9	rifampicin
rpoB	762416	c.2610A>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoB	762431	c.2625C>T	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	762449	c.2643C>A	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	762470	c.2664G>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	762491	c.2685T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	762509	c.-861T>G	upstream_gene_variant	0.74	rifampicin
rpoB	762510	p.Ala902Pro	missense_variant	0.74	rifampicin	Uncertain significance
rpoC	762902	c.-468C>T	upstream_gene_variant	0.9	rifampicin
rpoC	762917	c.-453C>T	upstream_gene_variant	0.85	rifampicin
rpoB	762929	c.3123G>T	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoB	762962	c.3156C>T	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	762983	c.-387C>G	upstream_gene_variant	0.92	rifampicin
rpoB	762995	c.3189G>T	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	763031	c.3225T>C	synonymous_variant	1.0	rifampicin	Not assoc w R
rpoB	763034	c.3228C>G	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	763040	c.3234C>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	763050	c.-320C>T	upstream_gene_variant	0.94	rifampicin
rpoB	763070	c.3264T>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoB	763082	c.3276C>T	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoB	763085	c.3279C>G	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoB	763115	c.3309T>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoB	763127	c.3321G>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoB	763166	c.3360A>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	763169	c.-201A>G	upstream_gene_variant	0.9	rifampicin
rpoC	763402	c.33C>T	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	763409	c.40_42delCTTinsTTG	synonymous_variant	0.96	rifampicin
rpoC	763414	c.45T>G	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoC	763441	c.72C>T	synonymous_variant	0.97	rifampicin
rpoC	763444	c.75T>C	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoC	763456	c.87A>G	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoC	763486	c.117T>G	synonymous_variant	0.96	rifampicin
rpoC	763528	c.159G>A	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	763546	c.177A>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	763570	c.201G>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	763594	c.225C>T	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoC	763603	c.234C>T	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoC	763618	c.249C>T	synonymous_variant	0.95	rifampicin
rpoC	763636	c.267T>C	synonymous_variant	0.95	rifampicin
rpoC	763660	c.291T>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	763669	c.300C>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	763675	c.306C>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	763703	c.334_336delTCGinsAGC	synonymous_variant	0.9	rifampicin
rpoC	763709	c.340C>T	synonymous_variant	0.9	rifampicin
rpoC	763714	c.345G>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	763726	c.357C>T	synonymous_variant	0.93	rifampicin
rpoC	763732	c.363C>G	synonymous_variant	0.93	rifampicin
rpoC	763741	c.372C>T	synonymous_variant	0.92	rifampicin
rpoC	763744	c.375G>C	synonymous_variant	0.92	rifampicin
rpoC	763765	c.396T>G	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoC	763771	c.402C>T	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	763780	c.411C>G	synonymous_variant	0.88	rifampicin
rpoC	763792	p.Glu141Asp	missense_variant	0.9	rifampicin
rpoC	763801	c.432C>G	synonymous_variant	0.92	rifampicin
rpoC	763807	c.438T>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	763836	p.Ala156Val	missense_variant	0.91	rifampicin
rpoC	763851	p.Ala161Gly	missense_variant	0.89	rifampicin
rpoC	763855	c.486C>T	synonymous_variant	0.89	rifampicin
rpoC	763858	c.489A>G	synonymous_variant	0.9	rifampicin
rpoC	763872	p.Gly168Ala	missense_variant	0.91	rifampicin
rpoC	763876	p.Glu169Asp	missense_variant	0.91	rifampicin
rpoC	763879	c.510A>G	synonymous_variant	0.92	rifampicin
rpoC	763888	c.519G>C	synonymous_variant	0.91	rifampicin
rpoC	763891	c.522G>C	synonymous_variant	0.91	rifampicin
rpoC	763894	c.525A>G	synonymous_variant	0.91	rifampicin
rpoC	763936	c.567C>G	synonymous_variant	0.93	rifampicin
rpoC	763939	c.570G>A	synonymous_variant	0.92	rifampicin
rpoC	763951	c.582G>A	synonymous_variant	0.93	rifampicin
rpoC	763963	c.594C>G	synonymous_variant	0.98	rifampicin
rpoC	763967	p.Gly200Ser	missense_variant	0.98	rifampicin
rpoC	763972	c.603C>T	synonymous_variant	0.98	rifampicin
rpoC	763987	c.618C>T	synonymous_variant	0.98	rifampicin
rpoC	763996	c.627T>C	synonymous_variant	0.98	rifampicin
rpoC	764005	c.636G>C	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoC	764011	c.642T>C	synonymous_variant	0.96	rifampicin
rpoC	764024	c.655T>C	synonymous_variant	0.96	rifampicin
rpoC	764040	p.Ser224Thr	missense_variant	0.96	rifampicin
rpoC	764044	c.675T>G	synonymous_variant	0.95	rifampicin
rpoC	764059	c.690G>T	synonymous_variant	0.96	rifampicin
rpoC	764083	c.714A>G	synonymous_variant	0.96	rifampicin
rpoC	764098	c.729A>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	764101	c.732C>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	764140	c.771C>T	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	764159	c.790C>T	synonymous_variant	0.95	rifampicin
rpoC	764167	c.798G>A	synonymous_variant	0.92	rifampicin
rpoC	764188	c.819A>G	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoC	764195	p.Ser276Ile	missense_variant	0.94	rifampicin
rpoC	764215	c.846A>C	synonymous_variant	0.94	rifampicin
rpoC	764218	c.849C>T	synonymous_variant	0.94	rifampicin
rpoC	764242	c.873C>T	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoC	764245	c.876C>A	synonymous_variant	0.93	rifampicin
rpoC	764246	c.877_879delCTCinsTTG	synonymous_variant	0.93	rifampicin
rpoC	764263	c.894G>C	synonymous_variant	0.9	rifampicin
rpoC	764266	c.897T>C	synonymous_variant	0.89	rifampicin
rpoC	764278	c.909A>G	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	764497	c.1128A>G	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	764503	c.1134G>C	synonymous_variant	0.86	rifampicin
rpoC	764521	c.1152T>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	764527	c.1158C>T	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	764536	c.1167G>T	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	764539	c.1170C>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	764554	c.1185C>T	synonymous_variant	0.89	rifampicin
rpoC	764575	c.1206T>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	764578	c.1209C>G	synonymous_variant	0.94	rifampicin
rpoC	764593	c.1224C>T	synonymous_variant	0.94	rifampicin
rpoC	764605	c.1236G>A	synonymous_variant	1.0	rifampicin
rpoC	764626	c.1257C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764858	c.1489T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764887	c.1518G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764888	c.1519_1521delTTGinsCTC	synonymous_variant	1.0	rifampicin
rpoC	764896	c.1527C>T	synonymous_variant	1.0	rifampicin
rpoC	764902	c.1533C>T	synonymous_variant	0.96	rifampicin
rpoC	764911	c.1542A>G	synonymous_variant	0.96	rifampicin
rpoC	764923	c.1554A>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	764932	c.1563C>G	synonymous_variant	0.96	rifampicin
rpoC	764948	c.1579T>C	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	764968	c.1599T>C	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	765007	c.1638T>G	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	765008	c.1639T>C	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	765013	c.1644C>T	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	765019	c.1650A>G	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	765040	c.1671T>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	765041	c.1672T>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	765047	c.1678T>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoC	765065	c.1696C>T	synonymous_variant	0.8	rifampicin
rpoC	765073	c.1704G>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	765076	c.1707A>G	synonymous_variant	0.8	rifampicin
rpoC	765079	c.1710T>C	synonymous_variant	0.8	rifampicin
rpoC	765082	c.1713G>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	765089	c.1720T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	765103	c.1734G>A	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoC	765121	c.1752G>T	synonymous_variant	0.7	rifampicin
rpoC	765319	c.1950A>G	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoC	765328	p.His653Gln	missense_variant	0.93	rifampicin	Uncertain significance
rpoC	765330	p.Ser654Asn	missense_variant	0.93	rifampicin	Uncertain significance
rpoC	765334	c.1965C>T	synonymous_variant	0.93	rifampicin
rpoC	765343	c.1974G>A	synonymous_variant	0.93	rifampicin
rpoC	765352	c.1983G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	765367	c.1998C>G	synonymous_variant	0.9	rifampicin
rpoC	765370	c.2001G>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	765383	p.Met672Leu	missense_variant	0.9	rifampicin	Uncertain significance
rpoC	765493	c.2124G>C	synonymous_variant	1.0	rifampicin
rpoC	765499	c.2130C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765508	c.2139C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765517	c.2148C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765529	c.2160C>T	synonymous_variant	1.0	rifampicin
rpoC	765541	c.2172C>G	synonymous_variant	1.0	rifampicin
rpoC	765553	c.2184C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765556	c.2187G>C	synonymous_variant	1.0	rifampicin
rpoC	765562	c.2193G>C	synonymous_variant	1.0	rifampicin
rpoC	765578	c.2209C>T	synonymous_variant	1.0	rifampicin
rpoC	765622	p.Glu751Asp	missense_variant	1.0	rifampicin
rpoC	765625	c.2256C>T	synonymous_variant	1.0	rifampicin
rpoC	765628	c.2259G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765658	c.2289C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765670	c.2301C>T	synonymous_variant	1.0	rifampicin
rpoC	765814	c.2445A>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	765835	c.2466C>T	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	765883	c.2514C>G	synonymous_variant	0.94	rifampicin
rpoC	765886	c.2517C>G	synonymous_variant	0.88	rifampicin
rpoC	765892	c.2523T>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	765934	c.2565C>T	synonymous_variant	0.85	rifampicin
rpoC	765967	c.2598C>T	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	765982	c.2613C>G	synonymous_variant	0.72	rifampicin
rpoC	765994	c.2625A>T	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoC	766288	c.2919C>G	synonymous_variant	0.64	rifampicin
rpoC	766309	c.2940G>A	synonymous_variant	0.79	rifampicin
rpoC	766315	c.2946C>G	synonymous_variant	0.79	rifampicin
rpoC	766321	c.2952C>G	synonymous_variant	0.81	rifampicin
rpoC	766348	c.2979A>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	766369	c.3000C>G	synonymous_variant	0.92	rifampicin
rpoC	766381	c.3012C>T	synonymous_variant	0.89	rifampicin
rpoC	766384	c.3015A>G	synonymous_variant	0.93	rifampicin
rpoC	766393	c.3024C>G	synonymous_variant	0.93	rifampicin
rpoC	766402	c.3033C>G	synonymous_variant	0.93	rifampicin
rpoC	766408	c.3039C>T	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoC	766426	c.3057C>T	synonymous_variant	0.92	rifampicin
rpoC	766456	c.3087C>G	synonymous_variant	0.94	rifampicin
rpoC	766486	c.3117A>G	synonymous_variant	0.88	rifampicin
rpoC	766492	c.3123T>C	synonymous_variant	0.86	rifampicin
rpoC	766530	p.Arg1054Gln	missense_variant	0.8	rifampicin
rpoC	766549	c.3180G>C	synonymous_variant	0.83	rifampicin
rpoC	766573	c.3204T>C	synonymous_variant	0.89	rifampicin
rpoC	766585	c.3216T>C	synonymous_variant	0.9	rifampicin
rpoC	766594	c.3225G>C	synonymous_variant	0.9	rifampicin
rpoC	766607	p.Ile1080Leu	missense_variant	0.92	rifampicin
rpoC	766630	c.3261G>T	synonymous_variant	0.95	rifampicin
rpoC	766660	c.3291G>A	synonymous_variant	0.93	rifampicin
rpoC	766666	c.3297C>G	synonymous_variant	0.96	rifampicin
rpoC	766672	c.3303T>C	synonymous_variant	0.96	rifampicin
rpoC	766700	c.3331C>T	synonymous_variant	0.94	rifampicin
rpoC	766726	c.3357T>C	synonymous_variant	0.95	rifampicin
rpoC	766733	c.3364C>T	synonymous_variant	0.95	rifampicin
rpoC	766738	c.3369G>C	synonymous_variant	0.95	rifampicin
rpoC	766741	c.3372G>C	synonymous_variant	0.95	rifampicin
rpoC	766750	c.3381C>G	synonymous_variant	0.95	rifampicin
rpoC	766765	c.3396A>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	766774	c.3405T>C	synonymous_variant	0.95	rifampicin
rpoC	766798	c.3429C>G	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	766801	c.3432C>G	synonymous_variant	0.88	rifampicin
rpoC	766804	c.3435A>G	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	766843	c.3474T>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	766864	c.3495G>C	synonymous_variant	0.83	rifampicin
rpoC	766876	c.3507C>T	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	766883	p.Ser1172Ala	missense_variant	0.69	rifampicin	Uncertain significance
rpoC	766894	c.3525T>C	synonymous_variant	0.67	rifampicin
rpoC	766895	c.3526T>C	synonymous_variant	0.67	rifampicin
rpoC	766900	c.3531T>C	synonymous_variant	0.71	rifampicin
rpoC	766903	c.3534C>T	synonymous_variant	0.71	rifampicin
rpoC	766918	c.3549C>T	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	766933	c.3564A>G	synonymous_variant	0.85	rifampicin
rpoC	766945	c.3576A>G	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	766963	c.3594T>G	synonymous_variant	0.91	rifampicin
rpoC	766996	c.3627C>G	synonymous_variant	0.89	rifampicin
rpoC	767002	c.3633G>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	767009	c.3640_3642delTCGinsAGC	synonymous_variant	0.94	rifampicin
rpoC	767014	c.3645G>C	synonymous_variant	0.94	rifampicin
rpoC	767033	c.3664_3666delTCGinsAGT	synonymous_variant	0.94	rifampicin
rpoC	767059	c.3690T>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	767062	c.3693C>A	synonymous_variant	0.94	rifampicin
rpoC	767098	c.3729T>C	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoC	767119	c.3750A>G	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	767134	c.3765C>A	synonymous_variant	0.83	rifampicin
rpoC	767158	c.3789T>A	synonymous_variant	0.79	rifampicin
rpoC	767167	c.3798C>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	767180	p.Ala1271Gln	missense_variant	0.8	rifampicin
rpoC	767191	c.3822C>G	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	767206	c.3837C>G	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	767209	c.3840T>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	767221	c.3852C>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpsL	781134	c.-426T>C	upstream_gene_variant	0.91	streptomycin
rpsL	781138	c.-422C>G	upstream_gene_variant	0.91	streptomycin
rpsL	781143	c.-417T>C	upstream_gene_variant	0.91	streptomycin
rpsL	781152	c.-408G>A	upstream_gene_variant	0.9	streptomycin
rpsL	781571	c.12C>T	synonymous_variant	0.9	streptomycin
rpsL	781595	c.36T>C	synonymous_variant	0.85	streptomycin
rpsL	781598	c.39G>C	synonymous_variant	0.85	streptomycin
rpsL	781605	p.Ile16Val	missense_variant	0.85	streptomycin	Uncertain significance
rpsL	781608	p.Ser17Ala	missense_variant	0.92	streptomycin
rpsL	781616	c.57C>T	synonymous_variant	0.85	streptomycin
rpsL	781628	c.69T>C	synonymous_variant	0.85	streptomycin	Not assoc w R - Interim
rpsL	781655	c.96T>C	synonymous_variant	0.75	streptomycin
rpsL	781658	c.99A>G	synonymous_variant	0.75	streptomycin
rpsL	781682	c.123T>C	synonymous_variant	0.71	streptomycin
rpsL	781721	c.162C>T	synonymous_variant	0.58	streptomycin
rpsL	781772	c.213C>G	synonymous_variant	0.75	streptomycin
rpsL	781793	c.234G>C	synonymous_variant	0.82	streptomycin
rpsL	781808	c.249C>T	synonymous_variant	0.83	streptomycin
rpsL	781832	c.273T>G	synonymous_variant	0.87	streptomycin
rpsL	781835	c.276T>C	synonymous_variant	0.87	streptomycin	Not assoc w R - Interim
rpsL	781859	c.300T>G	synonymous_variant	0.86	streptomycin
rpsL	781865	c.306G>C	synonymous_variant	0.85	streptomycin
rpsL	781868	c.309T>C	synonymous_variant	0.86	streptomycin
rpsL	781871	c.312G>C	synonymous_variant	0.85	streptomycin
rpsL	781883	c.324G>A	synonymous_variant	0.85	streptomycin
rpsL	781886	c.327C>T	synonymous_variant	0.85	streptomycin
rpsL	781892	c.333A>G	synonymous_variant	0.88	streptomycin
rpsL	781898	c.339A>T	synonymous_variant	0.88	streptomycin
rpsL	781916	c.357T>C	synonymous_variant	0.88	streptomycin
rpsL	781929	p.Gly124Ser	missense_variant	0.89	streptomycin	Uncertain significance
rpsL	781933	c.374G>A	splice_region_variant&stop_retained_variant	0.89	streptomycin
rplC	800516	c.-293G>T	upstream_gene_variant	0.91	linezolid
rplC	800540	c.-269T>C	upstream_gene_variant	0.91	linezolid
rplC	800546	c.-263T>C	upstream_gene_variant	0.83	linezolid
rplC	800567	c.-242A>G	upstream_gene_variant	0.86	linezolid
rplC	800579	c.-230C>T	upstream_gene_variant	0.86	linezolid
rplC	800582	c.-227C>T	upstream_gene_variant	0.86	linezolid
rplC	800612	c.-197A>G	upstream_gene_variant	0.86	linezolid
rplC	800618	c.-191T>C	upstream_gene_variant	0.77	linezolid
rplC	800621	c.-188G>A	upstream_gene_variant	0.77	linezolid
rplC	800627	c.-182C>T	upstream_gene_variant	0.79	linezolid
rplC	800648	c.-161A>G	upstream_gene_variant	0.75	linezolid
rplC	800654	c.-155T>C	upstream_gene_variant	0.77	linezolid
rplC	800693	c.-116A>G	upstream_gene_variant	0.73	linezolid
rplC	800703	c.-106T>C	upstream_gene_variant	0.79	linezolid
rplC	800714	c.-95C>T	upstream_gene_variant	0.69	linezolid
rplC	800715	c.-94A>C	upstream_gene_variant	0.77	linezolid
rplC	800723	c.-86C>G	upstream_gene_variant	0.79	linezolid
rplC	800744	c.-65G>C	upstream_gene_variant	0.71	linezolid
rplC	800745	c.-64_-62delCTCinsTTG	upstream_gene_variant	0.71	linezolid
rplC	800759	c.-50C>T	upstream_gene_variant	0.71	linezolid
rplC	800762	c.-47T>G	upstream_gene_variant	0.79	linezolid
rplC	801246	c.438C>T	synonymous_variant	0.76	linezolid
rplC	801255	c.447C>A	synonymous_variant	0.76	linezolid
rplC	801267	c.459A>C	synonymous_variant	0.76	linezolid
rplC	801270	c.462T>C	synonymous_variant	0.76	linezolid
rplC	801273	c.465C>G	synonymous_variant	0.76	linezolid
rplC	801279	c.471G>C	synonymous_variant	0.76	linezolid
rplC	801285	c.477G>A	synonymous_variant	0.72	linezolid
rplC	801309	c.501C>G	synonymous_variant	0.76	linezolid
rplC	801312	c.504G>C	synonymous_variant	0.76	linezolid
rplC	801324	c.516T>C	synonymous_variant	0.75	linezolid
rplC	801330	c.522G>T	synonymous_variant	0.69	linezolid
rplC	801333	c.525G>C	synonymous_variant	0.65	linezolid
rplC	801339	c.531T>G	synonymous_variant	0.61	linezolid
rplC	801341	p.Leu178Gln	missense_variant	0.61	linezolid
rplC	801348	c.540T>G	synonymous_variant	0.61	linezolid
rplC	801349	p.Leu181Val	missense_variant	0.61	linezolid
rplC	801357	c.549T>C	synonymous_variant	0.62	linezolid
fbiC	1303506	c.576C>T	synonymous_variant	0.88	pretomanid
					delamanid
					clofazimine
fbiC	1303512	c.582T>C	synonymous_variant	0.89	pretomanid
					delamanid
					clofazimine
fbiC	1303534	p.Ser202Ala	missense_variant	0.93	pretomanid
					delamanid
					clofazimine
fbiC	1303538	p.Arg203Leu	missense_variant	0.93	pretomanid
					delamanid
					clofazimine
fbiC	1303545	c.615A>G	synonymous_variant	0.94	pretomanid
					delamanid
					clofazimine
fbiC	1303575	c.645G>C	synonymous_variant	0.88	pretomanid
					delamanid
					clofazimine
fbiC	1303578	c.648G>A	synonymous_variant	0.86	pretomanid
					delamanid
					clofazimine
fbiC	1303584	c.654C>G	synonymous_variant	0.86	pretomanid
					delamanid
					clofazimine
fbiC	1303596	c.666G>C	synonymous_variant	0.83	pretomanid
					delamanid
					clofazimine
fbiC	1303605	c.675C>G	synonymous_variant	0.82	pretomanid
					delamanid
					clofazimine
fbiC	1303608	c.678G>A	synonymous_variant	0.82	pretomanid
					delamanid
					clofazimine
fbiC	1303614	c.684C>T	synonymous_variant	0.81	pretomanid
					delamanid
					clofazimine
fbiC	1303617	c.687C>G	synonymous_variant	0.81	pretomanid
					delamanid
					clofazimine
fbiC	1303620	c.690C>T	synonymous_variant	0.81	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
fbiC	1303629	c.699C>T	synonymous_variant	0.84	pretomanid
					delamanid
					clofazimine
fbiC	1303632	c.702T>G	synonymous_variant	0.84	pretomanid
					delamanid
					clofazimine
fbiC	1303659	c.729T>C	synonymous_variant	0.81	pretomanid
					delamanid
					clofazimine
fbiC	1303661	p.Val244Ala	missense_variant	0.81	pretomanid
					delamanid
					clofazimine
fbiC	1303674	c.744C>G	synonymous_variant	0.82	pretomanid
					delamanid
					clofazimine
fbiC	1303686	c.756C>G	synonymous_variant	0.77	pretomanid
					delamanid
					clofazimine
fbiC	1303704	c.774T>C	synonymous_variant	0.78	pretomanid
					delamanid
					clofazimine
fbiC	1303708	c.778T>C	synonymous_variant	0.76	pretomanid
					delamanid
					clofazimine
fbiC	1303729	c.799_801delCTAinsTTG	synonymous_variant	0.85	pretomanid
					delamanid
					clofazimine
fbiC	1303732	p.Ser268Ala	missense_variant	0.75	pretomanid
					delamanid
					clofazimine
fbiC	1303737	c.807G>A	synonymous_variant	0.83	pretomanid
					delamanid
					clofazimine
fbiC	1303746	c.816T>C	synonymous_variant	0.83	pretomanid
					delamanid
					clofazimine
fbiC	1303750	c.820_822delTTAinsCTG	synonymous_variant	0.91	pretomanid
					delamanid
					clofazimine
fbiC	1303755	c.825T>C	synonymous_variant	0.9	pretomanid
					delamanid
					clofazimine
fbiC	1304481	c.1551T>G	synonymous_variant	0.69	pretomanid
					delamanid
					clofazimine
fbiC	1304496	c.1566T>A	synonymous_variant	0.72	pretomanid
					delamanid
					clofazimine
fbiC	1304499	c.1569T>G	synonymous_variant	0.74	pretomanid
					delamanid
					clofazimine	Not assoc w R - Interim
fbiC	1304502	c.1572G>C	synonymous_variant	0.76	pretomanid
					delamanid
					clofazimine
fbiC	1304526	c.1596T>G	synonymous_variant	0.79	pretomanid
					delamanid
					clofazimine
fbiC	1304532	c.1602G>C	synonymous_variant	0.79	pretomanid
					delamanid
					clofazimine
fbiC	1304533	c.1603T>C	synonymous_variant	0.79	pretomanid
					delamanid
					clofazimine
fbiC	1304541	c.1611C>G	synonymous_variant	0.78	pretomanid
					delamanid
					clofazimine
fbiC	1304544	c.1614T>C	synonymous_variant	0.79	pretomanid
					delamanid
					clofazimine
fbiC	1304546	p.Val539Ala	missense_variant	0.81	pretomanid
					delamanid
					clofazimine
fbiC	1304559	p.Glu543Asp	missense_variant	0.84	pretomanid
					delamanid
					clofazimine
fbiC	1304565	c.1635C>G	synonymous_variant	0.84	pretomanid
					delamanid
					clofazimine
fbiC	1304568	c.1638T>C	synonymous_variant	0.84	pretomanid
					delamanid
					clofazimine
fbiC	1304574	c.1644C>G	synonymous_variant	0.87	pretomanid
					delamanid
					clofazimine
fbiC	1304580	c.1650T>C	synonymous_variant	0.84	pretomanid
					delamanid
					clofazimine
fbiC	1304610	c.1680C>G	synonymous_variant	0.81	pretomanid
					delamanid
					clofazimine
fbiC	1304613	c.1683T>A	synonymous_variant	0.81	pretomanid
					delamanid
					clofazimine
fbiC	1304625	c.1695C>T	synonymous_variant	0.88	pretomanid
					delamanid
					clofazimine
fbiC	1304634	c.1704C>G	synonymous_variant	0.85	pretomanid
					delamanid
					clofazimine
fbiC	1304640	c.1710A>C	synonymous_variant	0.89	pretomanid
					delamanid
					clofazimine
fbiC	1304646	c.1716T>C	synonymous_variant	0.89	pretomanid
					delamanid
					clofazimine
fbiC	1304658	c.1728C>G	synonymous_variant	0.73	pretomanid
					delamanid
					clofazimine
fbiC	1304670	c.1740G>C	synonymous_variant	0.71	pretomanid
					delamanid
					clofazimine
fbiC	1304672	p.Val581Ala	missense_variant	0.71	pretomanid
					delamanid
					clofazimine
fbiC	1304674	p.Gly582Gln	missense_variant	0.71	pretomanid
					delamanid
					clofazimine
fbiC	1304694	c.1764A>C	synonymous_variant	0.73	pretomanid
					delamanid
					clofazimine
fbiC	1304760	c.1830G>C	synonymous_variant	0.73	pretomanid
					delamanid
					clofazimine
fbiC	1304778	c.1848T>C	synonymous_variant	0.67	pretomanid
					delamanid
					clofazimine
fbiC	1304784	c.1854T>G	synonymous_variant	0.67	pretomanid
					delamanid
					clofazimine
fbiC	1304787	c.1857T>C	synonymous_variant	0.67	pretomanid
					delamanid
					clofazimine
fbiC	1304797	p.Ala623Asn	missense_variant	0.59	pretomanid
					delamanid
					clofazimine
fbiC	1304811	c.1881C>G	synonymous_variant	0.67	pretomanid
					delamanid
					clofazimine
fbiC	1304817	c.1887T>C	synonymous_variant	0.7	pretomanid
					delamanid
					clofazimine
fbiC	1304823	c.1893C>T	synonymous_variant	0.73	pretomanid
					delamanid
					clofazimine
fbiC	1304832	c.1902C>G	synonymous_variant	0.75	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
fbiC	1304853	c.1923C>G	synonymous_variant	0.75	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
fbiC	1304856	c.1926C>G	synonymous_variant	0.75	pretomanid
					delamanid
					clofazimine
fbiC	1304868	c.1938G>C	synonymous_variant	0.74	pretomanid
					delamanid
					clofazimine
fbiC	1304871	c.1941G>T	synonymous_variant	0.74	pretomanid
					delamanid
					clofazimine
fbiC	1304872	c.1942_1943delAGinsTC	synonymous_variant	0.74	pretomanid
					delamanid
					clofazimine
fbiC	1304875	p.Ile649Val	missense_variant	0.74	pretomanid
					delamanid
					clofazimine
fbiC	1304883	c.1953G>A	synonymous_variant	0.75	pretomanid
					delamanid
					clofazimine
fbiC	1304893	p.Gly655Ser	missense_variant	0.76	pretomanid
					delamanid
					clofazimine
fbiC	1304915	p.Asp662Gly	missense_variant	0.81	pretomanid
					delamanid
					clofazimine
fbiC	1304928	c.1998T>C	synonymous_variant	0.8	pretomanid
					delamanid
					clofazimine
fbiC	1304934	c.2004C>G	synonymous_variant	0.8	pretomanid
					delamanid
					clofazimine
fbiC	1304937	c.2007G>C	synonymous_variant	0.75	pretomanid
					delamanid
					clofazimine
fbiC	1304946	c.2016G>C	synonymous_variant	0.8	pretomanid
					delamanid
					clofazimine
fbiC	1304955	c.2025G>A	synonymous_variant	0.92	pretomanid
					delamanid
					clofazimine
rrs	1473105	n.1260G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1473123	n.1278delAinsTT	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473288	n.1443C>T	non_coding_transcript_exon_variant	0.94	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	0.94	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1473291	n.1446G>T	non_coding_transcript_exon_variant	0.94	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473797	n.140G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473797	n.140G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1473813	n.156C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473813	n.156C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473831	n.174G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473831	n.174G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1473876	n.219G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473876	n.219G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1473887	n.230T>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473887	n.230T>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473888	n.231T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473888	n.231T>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1473899	n.242A>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473899	n.242A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473918	n.261C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473918	n.261C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473924	n.267_268insT	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473924	n.267_268insT	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473942	n.285G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473942	n.285G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473943	n.286G>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473943	n.286G>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473945	n.288T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473945	n.288T>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473946	n.289A>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473946	n.289A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473981	n.324delGinsAT	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473981	n.324delGinsAT	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473986	n.329T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473986	n.329T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473994	n.337C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473994	n.337C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	1.0	linezolid	Not assoc w R
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474011	n.354G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474011	n.354G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474018	n.361G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474018	n.361G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474089	n.432C>T	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1474089	n.432C>T	non_coding_transcript_exon_variant	0.93	linezolid
rrl	1474093	n.436G>A	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1474093	n.436G>A	non_coding_transcript_exon_variant	0.93	linezolid
rrl	1474100	n.443C>T	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1474100	n.443C>T	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1474110	n.453A>G	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1474110	n.453A>G	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1474111	n.454T>C	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1474111	n.454T>C	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476580	n.2923G>A	non_coding_transcript_exon_variant	0.64	capreomycin
rrl	1476580	n.2923G>A	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.6	linezolid
inhA	1673565	c.-637G>C	upstream_gene_variant	1.0	isoniazid
inhA	1673565	c.-637G>C	upstream_gene_variant	1.0	ethionamide
inhA	1673580	c.-622T>C	upstream_gene_variant	1.0	isoniazid	Uncertain significance
inhA	1673580	c.-622T>C	upstream_gene_variant	1.0	ethionamide
inhA	1673589	c.-613A>G	upstream_gene_variant	1.0	isoniazid
inhA	1673589	c.-613A>G	upstream_gene_variant	1.0	ethionamide
inhA	1673595	c.-607A>C	upstream_gene_variant	1.0	isoniazid
inhA	1673595	c.-607A>C	upstream_gene_variant	1.0	ethionamide
inhA	1673596	c.-606A>G	upstream_gene_variant	1.0	isoniazid
inhA	1673596	c.-606A>G	upstream_gene_variant	1.0	ethionamide
inhA	1673604	c.-598G>C	upstream_gene_variant	1.0	isoniazid
inhA	1673604	c.-598G>C	upstream_gene_variant	1.0	ethionamide
inhA	1673607	c.-595T>C	upstream_gene_variant	0.92	isoniazid
inhA	1673607	c.-595T>C	upstream_gene_variant	0.92	ethionamide
inhA	1673615	c.-587_-586delAAinsTG	upstream_gene_variant	0.85	isoniazid
inhA	1673615	c.-587_-586delAAinsTG	upstream_gene_variant	0.85	ethionamide
inhA	1673633	c.-569G>A	upstream_gene_variant	0.77	isoniazid
inhA	1673633	c.-569G>A	upstream_gene_variant	0.77	ethionamide
inhA	1673646	c.-556T>C	upstream_gene_variant	0.69	isoniazid
inhA	1673646	c.-556T>C	upstream_gene_variant	0.69	ethionamide
inhA	1673657	c.-545C>A	upstream_gene_variant	0.69	isoniazid
inhA	1673657	c.-545C>A	upstream_gene_variant	0.69	ethionamide
inhA	1673660	c.-542C>A	upstream_gene_variant	0.67	isoniazid
inhA	1673660	c.-542C>A	upstream_gene_variant	0.67	ethionamide
inhA	1673664	c.-538A>C	upstream_gene_variant	0.67	isoniazid
inhA	1673664	c.-538A>C	upstream_gene_variant	0.67	ethionamide
inhA	1673667	c.-535A>G	upstream_gene_variant	0.67	isoniazid
inhA	1673667	c.-535A>G	upstream_gene_variant	0.67	ethionamide
inhA	1673679	c.-523T>C	upstream_gene_variant	0.64	isoniazid	Uncertain significance
inhA	1673679	c.-523T>C	upstream_gene_variant	0.64	ethionamide	Uncertain significance
inhA	1674669	c.468G>C	synonymous_variant	0.92	isoniazid
inhA	1674669	c.468G>C	synonymous_variant	0.92	ethionamide
inhA	1674729	c.528G>A	synonymous_variant	0.94	isoniazid
inhA	1674729	c.528G>A	synonymous_variant	0.94	ethionamide
inhA	1674745	p.Tyr182Ala	missense_variant	0.95	isoniazid
inhA	1674745	p.Tyr182Ala	missense_variant	0.95	ethionamide
inhA	1674756	c.555T>C	synonymous_variant	0.95	isoniazid	Not assoc w R - Interim
inhA	1674756	c.555T>C	synonymous_variant	0.95	ethionamide	Not assoc w R - Interim
inhA	1674759	c.558G>C	synonymous_variant	0.95	isoniazid
inhA	1674759	c.558G>C	synonymous_variant	0.95	ethionamide
inhA	1674765	c.564C>T	synonymous_variant	0.95	isoniazid
inhA	1674765	c.564C>T	synonymous_variant	0.95	ethionamide
inhA	1674774	c.573A>C	synonymous_variant	0.94	isoniazid
inhA	1674774	c.573A>C	synonymous_variant	0.94	ethionamide
inhA	1674777	c.576C>A	synonymous_variant	0.94	isoniazid
inhA	1674777	c.576C>A	synonymous_variant	0.94	ethionamide
inhA	1674780	c.579T>G	synonymous_variant	0.94	isoniazid
inhA	1674780	c.579T>G	synonymous_variant	0.94	ethionamide
inhA	1674792	c.591G>C	synonymous_variant	0.94	isoniazid
inhA	1674792	c.591G>C	synonymous_variant	0.94	ethionamide
inhA	1674801	c.600T>C	synonymous_variant	1.0	isoniazid
inhA	1674801	c.600T>C	synonymous_variant	1.0	ethionamide
inhA	1674820	c.619_621delCTCinsTTG	synonymous_variant	1.0	isoniazid
inhA	1674820	c.619_621delCTCinsTTG	synonymous_variant	1.0	ethionamide
inhA	1674828	c.627G>A	synonymous_variant	1.0	isoniazid
inhA	1674828	c.627G>A	synonymous_variant	1.0	ethionamide
inhA	1674846	p.Ile215Met	missense_variant	1.0	isoniazid
inhA	1674846	p.Ile215Met	missense_variant	1.0	ethionamide
inhA	1674870	c.669T>C	synonymous_variant	0.94	isoniazid
inhA	1674870	c.669T>C	synonymous_variant	0.94	ethionamide
inhA	1674876	c.675C>G	synonymous_variant	0.94	isoniazid
inhA	1674876	c.675C>G	synonymous_variant	0.94	ethionamide
inhA	1674879	c.678T>C	synonymous_variant	0.94	isoniazid
inhA	1674879	c.678T>C	synonymous_variant	0.94	ethionamide
inhA	1674888	c.687C>T	synonymous_variant	0.93	isoniazid
inhA	1674888	c.687C>T	synonymous_variant	0.93	ethionamide
inhA	1674904	p.Ala235Pro	missense_variant	0.93	isoniazid
inhA	1674904	p.Ala235Pro	missense_variant	0.93	ethionamide
inhA	1674909	c.708G>C	synonymous_variant	0.93	isoniazid
inhA	1674909	c.708G>C	synonymous_variant	0.93	ethionamide
inhA	1674915	c.714C>G	synonymous_variant	0.94	isoniazid
inhA	1674915	c.714C>G	synonymous_variant	0.94	ethionamide
inhA	1674939	c.738G>A	synonymous_variant	0.95	isoniazid	Not assoc w R - Interim
inhA	1674939	c.738G>A	synonymous_variant	0.95	ethionamide	Not assoc w R - Interim
inhA	1674942	c.741T>C	synonymous_variant	0.95	isoniazid
inhA	1674942	c.741T>C	synonymous_variant	0.95	ethionamide
inhA	1674966	c.765T>C	synonymous_variant	0.96	isoniazid
inhA	1674966	c.765T>C	synonymous_variant	0.96	ethionamide
inhA	1674967	p.Asp256Thr	missense_variant	0.96	isoniazid
inhA	1674967	p.Asp256Thr	missense_variant	0.96	ethionamide
inhA	1674993	c.792G>C	synonymous_variant	0.95	isoniazid
inhA	1674993	c.792G>C	synonymous_variant	0.95	ethionamide
inhA	1674994	p.His265Ser	missense_variant	0.95	isoniazid
inhA	1674994	p.His265Ser	missense_variant	0.95	ethionamide
inhA	1675006	c.805_807delCTCinsTTG	synonymous_variant	1.0	isoniazid
inhA	1675006	c.805_807delCTCinsTTG	synonymous_variant	1.0	ethionamide
rpsA	1833568	c.27G>C	synonymous_variant	0.94	pyrazinamide	Not assoc w R - Interim
rpsA	1833589	c.48A>T	synonymous_variant	0.95	pyrazinamide
rpsA	1833595	c.54T>C	synonymous_variant	0.95	pyrazinamide
rpsA	1833613	c.72C>A	synonymous_variant	0.93	pyrazinamide
rpsA	1833619	c.78A>C	synonymous_variant	0.93	pyrazinamide
rpsA	1833661	c.120A>G	synonymous_variant	0.94	pyrazinamide
rpsA	1833667	c.126C>G	synonymous_variant	0.94	pyrazinamide
rpsA	1833703	c.162C>T	synonymous_variant	0.91	pyrazinamide	Not assoc w R - Interim
rpsA	1833724	c.183C>G	synonymous_variant	0.94	pyrazinamide
rpsA	1833727	c.186G>C	synonymous_variant	0.94	pyrazinamide
rpsA	1833745	c.204G>C	synonymous_variant	0.94	pyrazinamide
rpsA	1833760	c.219C>T	synonymous_variant	0.93	pyrazinamide	Not assoc w R - Interim
rpsA	1833790	c.249T>C	synonymous_variant	0.93	pyrazinamide
rpsA	1833793	c.252C>T	synonymous_variant	0.91	pyrazinamide
rpsA	1833802	c.261A>G	synonymous_variant	0.91	pyrazinamide
rpsA	1833808	c.267G>C	synonymous_variant	0.91	pyrazinamide
rpsA	1833811	c.270G>T	synonymous_variant	0.91	pyrazinamide
rpsA	1833832	c.291G>A	synonymous_variant	0.9	pyrazinamide
rpsA	1833838	c.297G>C	synonymous_variant	0.9	pyrazinamide
rpsA	1833841	c.300C>G	synonymous_variant	0.89	pyrazinamide
rpsA	1833847	c.306C>G	synonymous_variant	0.9	pyrazinamide
rpsA	1833856	c.315A>G	synonymous_variant	0.96	pyrazinamide
rpsA	1833859	c.318C>T	synonymous_variant	0.93	pyrazinamide
rpsA	1833874	c.333T>C	synonymous_variant	0.91	pyrazinamide
rpsA	1833895	c.354G>C	synonymous_variant	0.97	pyrazinamide
rpsA	1833928	c.387G>C	synonymous_variant	0.95	pyrazinamide
rpsA	1833949	c.408T>C	synonymous_variant	0.97	pyrazinamide
rpsA	1833964	c.423C>T	synonymous_variant	0.97	pyrazinamide	Not assoc w R - Interim
rpsA	1833970	c.429G>A	synonymous_variant	0.97	pyrazinamide
rpsA	1833979	c.438T>C	synonymous_variant	0.97	pyrazinamide
rpsA	1834000	c.459G>C	synonymous_variant	0.97	pyrazinamide
rpsA	1834015	c.474G>C	synonymous_variant	0.97	pyrazinamide
rpsA	1834021	c.480C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834102	c.561T>C	synonymous_variant	0.95	pyrazinamide
rpsA	1834105	c.564C>T	synonymous_variant	0.95	pyrazinamide
rpsA	1834150	c.609G>C	synonymous_variant	0.91	pyrazinamide
rpsA	1834153	c.612T>C	synonymous_variant	0.9	pyrazinamide
rpsA	1834154	p.Asn205Gln	missense_variant	0.91	pyrazinamide
rpsA	1834157	c.616T>C	synonymous_variant	0.91	pyrazinamide
rpsA	1834162	c.621A>G	synonymous_variant	0.91	pyrazinamide	Not assoc w R - Interim
rpsA	1834165	c.624A>G	synonymous_variant	0.91	pyrazinamide
rpsA	1834177	c.636A>C	synonymous_variant	0.92	pyrazinamide	Not assoc w R - Interim
rpsA	1834186	c.645C>G	synonymous_variant	0.92	pyrazinamide
rpsA	1834189	c.648G>C	synonymous_variant	0.92	pyrazinamide
rpsA	1834195	c.654G>C	synonymous_variant	0.92	pyrazinamide
rpsA	1834222	c.681T>C	synonymous_variant	0.93	pyrazinamide
rpsA	1834225	c.684C>G	synonymous_variant	0.96	pyrazinamide
rpsA	1834231	c.690T>G	synonymous_variant	0.97	pyrazinamide
rpsA	1834249	c.708T>C	synonymous_variant	0.97	pyrazinamide
rpsA	1834261	c.720A>G	synonymous_variant	0.96	pyrazinamide	Not assoc w R - Interim
rpsA	1834264	c.723G>C	synonymous_variant	0.96	pyrazinamide
rpsA	1834297	c.756C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834303	c.762T>G	synonymous_variant	0.96	pyrazinamide
rpsA	1834306	c.765T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834336	c.795C>G	synonymous_variant	1.0	pyrazinamide
rpsA	1834348	c.807T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
rpsA	1834357	c.816T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834366	c.825A>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
rpsA	1834375	c.834G>A	synonymous_variant	1.0	pyrazinamide
rpsA	1834396	c.855G>T	synonymous_variant	0.97	pyrazinamide
rpsA	1834411	c.870T>C	synonymous_variant	0.97	pyrazinamide
rpsA	1834423	c.882G>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834451	c.910T>C	synonymous_variant	0.96	pyrazinamide
rpsA	1834456	c.915T>G	synonymous_variant	0.96	pyrazinamide
rpsA	1834465	c.924T>C	synonymous_variant	0.96	pyrazinamide
rpsA	1834468	c.927A>G	synonymous_variant	0.95	pyrazinamide
rpsA	1834477	c.936C>T	synonymous_variant	0.95	pyrazinamide	Not assoc w R - Interim
rpsA	1834489	c.948T>C	synonymous_variant	0.88	pyrazinamide
rpsA	1834519	c.978G>C	synonymous_variant	0.93	pyrazinamide
rpsA	1834546	c.1005T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834555	c.1014T>G	synonymous_variant	1.0	pyrazinamide
rpsA	1834603	c.1062G>A	synonymous_variant	0.95	pyrazinamide
rpsA	1834609	c.1068T>C	synonymous_variant	0.95	pyrazinamide
rpsA	1834612	c.1071G>A	synonymous_variant	0.95	pyrazinamide	Not assoc w R - Interim
rpsA	1834633	c.1092A>G	synonymous_variant	0.95	pyrazinamide
rpsA	1834639	c.1098T>C	synonymous_variant	0.95	pyrazinamide
rpsA	1834654	c.1113G>A	synonymous_variant	0.95	pyrazinamide
rpsA	1834690	c.1149T>C	synonymous_variant	0.94	pyrazinamide
rpsA	1834699	p.Glu386Asp	missense_variant	0.88	pyrazinamide
rpsA	1834732	c.1191T>C	synonymous_variant	0.91	pyrazinamide
tsnR	1853369	c.-237C>T	upstream_gene_variant	0.9	linezolid
tsnR	1853370	c.-236_-234delGCAinsTCG	upstream_gene_variant	0.9	linezolid
tsnR	1853384	c.-222G>C	upstream_gene_variant	0.9	linezolid
tsnR	1853387	c.-219T>G	upstream_gene_variant	0.9	linezolid
tsnR	1853390	c.-216G>C	upstream_gene_variant	0.9	linezolid
tsnR	1853393	c.-213C>T	upstream_gene_variant	0.9	linezolid
tsnR	1853394	c.-212_-211delCTinsGC	upstream_gene_variant	0.9	linezolid
tsnR	1853420	c.-186T>G	upstream_gene_variant	0.9	linezolid
tsnR	1853429	c.-177G>C	upstream_gene_variant	0.89	linezolid
tsnR	1853441	c.-165C>G	upstream_gene_variant	0.87	linezolid
tsnR	1853447	c.-159C>G	upstream_gene_variant	0.83	linezolid
tsnR	1853450	c.-156G>A	upstream_gene_variant	0.82	linezolid
tsnR	1853453	c.-153G>C	upstream_gene_variant	0.82	linezolid
tsnR	1853462	c.-144A>G	upstream_gene_variant	0.82	linezolid
ndh	2102836	c.207T>C	synonymous_variant	0.9	isoniazid
					delamanid
					ethionamide
ndh	2102842	c.201A>G	synonymous_variant	0.92	isoniazid
					delamanid
					ethionamide
ndh	2102845	c.198A>C	synonymous_variant	0.92	isoniazid
					delamanid
					ethionamide
ndh	2102857	c.186T>C	synonymous_variant	0.93	isoniazid	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					ethionamide	Not assoc w R - Interim
ndh	2102863	c.180C>T	synonymous_variant	0.93	isoniazid	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					ethionamide	Not assoc w R - Interim
ndh	2102869	c.174G>T	synonymous_variant	0.93	isoniazid
					delamanid
					ethionamide
ndh	2102872	c.171A>G	synonymous_variant	0.87	isoniazid
					delamanid
					ethionamide
ndh	2102878	c.165G>C	synonymous_variant	0.87	isoniazid
					delamanid
					ethionamide
ndh	2102883	c.160C>T	synonymous_variant	0.87	isoniazid
					delamanid
					ethionamide
ndh	2102895	c.148C>T	synonymous_variant	0.87	isoniazid	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					ethionamide	Not assoc w R - Interim
ndh	2102902	c.141C>G	synonymous_variant	0.86	isoniazid
					delamanid
					ethionamide
ndh	2102908	c.135C>G	synonymous_variant	0.86	isoniazid
					delamanid
					ethionamide
ndh	2102914	c.129C>T	synonymous_variant	0.85	isoniazid
					delamanid
					ethionamide
ndh	2102919	c.124C>T	synonymous_variant	0.85	isoniazid	Not assoc w R - Interim
					delamanid
					ethionamide	Not assoc w R - Interim
ndh	2102929	c.114T>C	synonymous_variant	0.85	isoniazid
					delamanid
					ethionamide
ndh	2102938	p.Arg35His	missense_variant	0.85	isoniazid
					delamanid
					ethionamide
ndh	2102959	c.84C>T	synonymous_variant	0.9	isoniazid
					delamanid
					ethionamide
ndh	2102962	c.81A>C	synonymous_variant	0.9	isoniazid
					delamanid
					ethionamide
kasA	2517941	c.-174C>G	upstream_gene_variant	0.94	isoniazid
kasA	2517950	c.-165C>G	upstream_gene_variant	0.95	isoniazid
kasA	2517962	c.-153C>G	upstream_gene_variant	0.95	isoniazid
kasA	2517965	c.-150C>T	upstream_gene_variant	0.95	isoniazid
kasA	2517974	c.-141T>C	upstream_gene_variant	0.95	isoniazid
kasA	2517983	c.-132T>C	upstream_gene_variant	0.95	isoniazid
kasA	2517989	c.-126T>G	upstream_gene_variant	0.94	isoniazid
kasA	2517993	c.-122G>T	upstream_gene_variant	0.94	isoniazid
kasA	2518019	c.-96A>G	upstream_gene_variant	0.93	isoniazid
kasA	2518025	c.-90G>C	upstream_gene_variant	0.92	isoniazid
kasA	2518031	c.-84G>T	upstream_gene_variant	0.93	isoniazid
kasA	2518034	c.-81T>C	upstream_gene_variant	0.92	isoniazid
kasA	2518040	c.-75G>T	upstream_gene_variant	0.93	isoniazid
kasA	2518041	c.-74T>C	upstream_gene_variant	0.93	isoniazid
kasA	2518049	c.-66G>C	upstream_gene_variant	0.83	isoniazid
kasA	2518053	c.-62_-60delATTinsCTG	upstream_gene_variant	0.82	isoniazid
kasA	2518073	c.-42T>G	upstream_gene_variant	0.83	isoniazid
kasA	2518169	p.Val19Leu	missense_variant	0.8	isoniazid
kasA	2518172	p.Thr20Ala	missense_variant	0.8	isoniazid
kasA	2518190	p.Ser26Ala	missense_variant	0.8	isoniazid
kasA	2518492	c.378C>T	synonymous_variant	0.62	isoniazid
kasA	2518504	c.390T>C	synonymous_variant	0.62	isoniazid
kasA	2518506	p.Ala131Glu	missense_variant	0.62	isoniazid
kasA	2518519	c.405G>C	synonymous_variant	0.71	isoniazid
kasA	2518528	c.414C>G	synonymous_variant	0.75	isoniazid
kasA	2518534	c.420G>C	synonymous_variant	0.75	isoniazid
kasA	2518561	c.447T>C	synonymous_variant	0.86	isoniazid
kasA	2518567	c.453G>C	synonymous_variant	0.86	isoniazid
kasA	2518570	c.456G>C	synonymous_variant	0.86	isoniazid
kasA	2518573	c.459G>C	synonymous_variant	0.86	isoniazid
kasA	2518574	p.Ile154Val	missense_variant	0.86	isoniazid
kasA	2518582	c.468G>C	synonymous_variant	0.86	isoniazid
kasA	2518583	p.Gln157Glu	missense_variant	0.86	isoniazid
kasA	2518594	c.480C>T	synonymous_variant	0.87	isoniazid
kasA	2518597	c.483C>G	synonymous_variant	0.87	isoniazid
kasA	2518606	c.492G>C	synonymous_variant	0.93	isoniazid
kasA	2518609	p.Met165Ile	missense_variant	0.93	isoniazid
kasA	2518636	c.522C>A	synonymous_variant	0.9	isoniazid
kasA	2518639	c.525G>C	synonymous_variant	0.9	isoniazid
kasA	2518642	c.528A>G	synonymous_variant	0.9	isoniazid
kasA	2518645	c.531G>C	synonymous_variant	0.9	isoniazid
kasA	2518651	c.537C>G	synonymous_variant	0.9	isoniazid
kasA	2518657	c.543G>C	synonymous_variant	0.9	isoniazid
kasA	2518663	c.549T>C	synonymous_variant	0.8	isoniazid
Rv2477c	2783299	c.744A>G	synonymous_variant	0.7	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783311	c.732T>C	synonymous_variant	0.75	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783314	c.729C>A	synonymous_variant	0.75	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783320	c.723C>T	synonymous_variant	0.77	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783332	c.711T>C	synonymous_variant	0.77	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783347	c.696C>G	synonymous_variant	0.83	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783350	c.693T>C	synonymous_variant	0.91	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783353	c.690T>C	synonymous_variant	0.91	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783362	c.681G>C	synonymous_variant	0.92	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783371	c.672A>G	synonymous_variant	0.92	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783374	c.669G>C	synonymous_variant	0.92	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783527	c.516A>G	synonymous_variant	0.8	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783535	c.508C>T	synonymous_variant	0.8	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783542	c.501G>A	synonymous_variant	0.83	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783548	c.495T>G	synonymous_variant	0.84	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783563	c.480A>C	synonymous_variant	0.81	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783572	c.471A>G	synonymous_variant	0.82	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783578	c.465G>A	synonymous_variant	0.82	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783602	c.441G>A	synonymous_variant	0.91	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783605	c.438T>C	synonymous_variant	0.91	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783623	c.420G>A	synonymous_variant	0.92	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783628	p.Ala139Ser	missense_variant	0.92	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783632	c.411C>G	synonymous_variant	0.88	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783656	c.387G>C	synonymous_variant	0.89	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783665	c.378A>G	synonymous_variant	0.88	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783860	c.183T>C	synonymous_variant	1.0	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783881	c.160_162delTTGinsCTC	synonymous_variant	1.0	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783884	c.159T>G	synonymous_variant	1.0	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783920	c.123G>T	synonymous_variant	1.0	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin
Rv2477c	2783938	c.105T>C	synonymous_variant	1.0	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783956	p.Tyr29Phe	missense_variant	1.0	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783962	c.81T>C	synonymous_variant	1.0	kanamycin	Not assoc w R - Interim
					levofloxacin
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783968	c.75G>C	synonymous_variant	1.0	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783971	c.72G>C	synonymous_variant	1.0	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783980	c.63C>G	synonymous_variant	1.0	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783992	c.51T>C	synonymous_variant	1.0	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin
Rv2752c	3065040	c.1150_1152delCTCinsTTG	synonymous_variant	1.0	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065049	c.1143G>A	synonymous_variant	1.0	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065055	c.1137T>G	synonymous_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065064	c.1128G>C	synonymous_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
Rv2752c	3065070	c.1122C>A	synonymous_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065073	c.1119C>G	synonymous_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
Rv2752c	3065085	c.1105_1107delAGGinsCGC	synonymous_variant	0.93	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065097	c.1095C>T	synonymous_variant	0.94	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065109	c.1081_1083delAGAinsCGG	synonymous_variant	0.95	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065130	c.1062A>G	synonymous_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065133	c.1059T>C	synonymous_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065142	c.1050A>C	synonymous_variant	0.92	levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
Rv2752c	3065146	p.Phe349Tyr	missense_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065154	c.1038G>A	synonymous_variant	0.91	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065186	c.1006T>C	synonymous_variant	0.81	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065190	p.Ile334Val	missense_variant	0.8	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065199	c.993T>C	synonymous_variant	0.8	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065202	c.990T>G	synonymous_variant	0.8	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065205	c.987T>C	synonymous_variant	0.86	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065210	c.982T>C	synonymous_variant	0.86	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065223	c.969T>C	synonymous_variant	0.86	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065229	c.963G>C	synonymous_variant	0.85	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065232	c.960T>C	synonymous_variant	0.83	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065235	c.957G>C	synonymous_variant	0.82	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065241	c.951A>G	synonymous_variant	0.8	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065550	c.642G>C	synonymous_variant	0.64	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065556	c.636G>T	synonymous_variant	0.6	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065562	c.630T>G	synonymous_variant	0.6	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066567	c.-376C>A	upstream_gene_variant	0.85	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066573	c.-382G>C	upstream_gene_variant	0.86	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066579	c.-388A>G	upstream_gene_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066583	c.-392C>G	upstream_gene_variant	0.93	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066597	c.-406C>T	upstream_gene_variant	0.93	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066603	c.-412A>G	upstream_gene_variant	0.93	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066612	c.-421G>A	upstream_gene_variant	0.93	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066617	c.-426G>A	upstream_gene_variant	0.93	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066618	c.-427A>G	upstream_gene_variant	0.93	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066633	c.-442T>C	upstream_gene_variant	0.93	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066644	c.-453T>C	upstream_gene_variant	0.87	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066647	c.-456G>A	upstream_gene_variant	0.87	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066654	c.-463G>C	upstream_gene_variant	0.87	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066676	c.-485C>T	upstream_gene_variant	0.93	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066685	c.-495_-494delGGinsCC	upstream_gene_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066687	c.-496G>T	upstream_gene_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066696	c.-505T>C	upstream_gene_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066707	c.-516A>G	upstream_gene_variant	0.83	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
thyA	3073944	c.528C>T	synonymous_variant	0.92	para-aminosalicylic_acid
thyA	3073953	c.519T>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyA	3073956	c.516G>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyA	3073959	c.513T>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyA	3073968	c.504C>G	synonymous_variant	1.0	para-aminosalicylic_acid
thyA	3073977	c.495A>G	synonymous_variant	1.0	para-aminosalicylic_acid
thyA	3073989	c.483T>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyA	3074001	c.471C>G	synonymous_variant	1.0	para-aminosalicylic_acid
thyA	3074004	c.468T>C	synonymous_variant	1.0	para-aminosalicylic_acid
thyA	3074256	c.216G>A	synonymous_variant	0.8	para-aminosalicylic_acid
thyA	3074267	p.Ile69Val	missense_variant	0.83	para-aminosalicylic_acid
thyA	3074268	c.204T>C	synonymous_variant	0.83	para-aminosalicylic_acid
thyA	3074274	c.198T>C	synonymous_variant	0.85	para-aminosalicylic_acid
thyA	3074280	c.192C>T	synonymous_variant	0.85	para-aminosalicylic_acid
thyA	3074297	c.175C>T	synonymous_variant	0.85	para-aminosalicylic_acid
thyA	3074301	c.171C>T	synonymous_variant	0.85	para-aminosalicylic_acid
thyA	3074305	p.Ala56Val	missense_variant	0.92	para-aminosalicylic_acid
thyA	3074307	c.165A>G	synonymous_variant	0.92	para-aminosalicylic_acid
thyA	3074313	c.159A>G	synonymous_variant	0.92	para-aminosalicylic_acid
thyA	3074316	p.Phe52Leu	missense_variant	0.92	para-aminosalicylic_acid
thyA	3074322	c.150C>G	synonymous_variant	0.92	para-aminosalicylic_acid
thyA	3074325	c.147A>G	synonymous_variant	0.92	para-aminosalicylic_acid
thyA	3074334	c.138T>C	synonymous_variant	0.92	para-aminosalicylic_acid
thyA	3074337	c.135C>G	synonymous_variant	0.92	para-aminosalicylic_acid
thyA	3074360	c.112T>C	synonymous_variant	0.92	para-aminosalicylic_acid
thyA	3074361	c.111T>C	synonymous_variant	0.92	para-aminosalicylic_acid
thyA	3074364	c.108T>C	synonymous_variant	0.92	para-aminosalicylic_acid
thyA	3074372	p.Met34Leu	missense_variant	0.92	para-aminosalicylic_acid
thyA	3074373	c.99G>A	synonymous_variant	0.92	para-aminosalicylic_acid
lpqB	3623360	c.1551A>C	synonymous_variant	0.55	rifampicin
lpqB	3623360	c.1551A>C	synonymous_variant	0.55	bedaquiline
lpqB	3623363	c.1548T>C	synonymous_variant	0.55	rifampicin
lpqB	3623363	c.1548T>C	synonymous_variant	0.55	bedaquiline
lpqB	3623366	c.1545T>C	synonymous_variant	0.64	rifampicin
lpqB	3623366	c.1545T>C	synonymous_variant	0.64	bedaquiline
lpqB	3623381	p.Ala510Ile	missense_variant	0.58	rifampicin
lpqB	3623381	p.Ala510Ile	missense_variant	0.58	bedaquiline
lpqB	3623388	p.Thr508Asn	missense_variant	0.58	rifampicin
lpqB	3623388	p.Thr508Asn	missense_variant	0.58	bedaquiline
lpqB	3623393	c.1518A>G	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
lpqB	3623393	c.1518A>G	synonymous_variant	0.57	bedaquiline	Not assoc w R - Interim
lpqB	3623424	p.Ser496Tyr	missense_variant	0.57	rifampicin
lpqB	3623424	p.Ser496Tyr	missense_variant	0.57	bedaquiline
lpqB	3623428	c.1483T>C	synonymous_variant	0.54	rifampicin
lpqB	3623428	c.1483T>C	synonymous_variant	0.54	bedaquiline
lpqB	3623429	c.1482G>C	synonymous_variant	0.54	rifampicin
lpqB	3623429	c.1482G>C	synonymous_variant	0.54	bedaquiline
lpqB	3625675	c.-765G>C	upstream_gene_variant	0.67	rifampicin
lpqB	3625675	c.-765G>C	upstream_gene_variant	0.67	bedaquiline
lpqB	3625687	c.-777G>C	upstream_gene_variant	0.75	rifampicin
lpqB	3625687	c.-777G>C	upstream_gene_variant	0.75	bedaquiline
lpqB	3625690	c.-780T>G	upstream_gene_variant	0.75	rifampicin
lpqB	3625690	c.-780T>G	upstream_gene_variant	0.75	bedaquiline
lpqB	3625696	c.-786A>G	upstream_gene_variant	0.71	rifampicin
lpqB	3625696	c.-786A>G	upstream_gene_variant	0.71	bedaquiline
mtrB	3625699	c.915C>T	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
mtrB	3625699	c.915C>T	synonymous_variant	0.71	bedaquiline
lpqB	3625717	c.-807C>T	upstream_gene_variant	0.75	rifampicin
lpqB	3625717	c.-807C>T	upstream_gene_variant	0.75	bedaquiline
mtrB	3625747	c.867G>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
mtrB	3625747	c.867G>C	synonymous_variant	0.77	bedaquiline
lpqB	3625762	c.-852A>C	upstream_gene_variant	0.78	rifampicin
lpqB	3625762	c.-852A>C	upstream_gene_variant	0.78	bedaquiline
mtrB	3625765	c.849C>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
mtrB	3625765	c.849C>G	synonymous_variant	0.79	bedaquiline
lpqB	3625783	c.-873C>T	upstream_gene_variant	0.81	rifampicin
lpqB	3625783	c.-873C>T	upstream_gene_variant	0.81	bedaquiline
lpqB	3625801	c.-891G>C	upstream_gene_variant	0.84	rifampicin
lpqB	3625801	c.-891G>C	upstream_gene_variant	0.84	bedaquiline
mtrB	3625806	c.808A>C	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
mtrB	3625806	c.808A>C	synonymous_variant	0.84	bedaquiline
lpqB	3625849	c.-939T>C	upstream_gene_variant	0.8	rifampicin
lpqB	3625849	c.-939T>C	upstream_gene_variant	0.8	bedaquiline
mtrB	3625852	c.762A>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
mtrB	3625852	c.762A>G	synonymous_variant	0.8	bedaquiline
lpqB	3625864	c.-954T>G	upstream_gene_variant	0.74	rifampicin
lpqB	3625864	c.-954T>G	upstream_gene_variant	0.74	bedaquiline
mtrB	3625867	c.747A>G	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
mtrB	3625867	c.747A>G	synonymous_variant	0.72	bedaquiline
lpqB	3625870	c.-960C>G	upstream_gene_variant	0.71	rifampicin
lpqB	3625870	c.-960C>G	upstream_gene_variant	0.71	bedaquiline
mtrB	3625876	c.738G>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
mtrB	3625876	c.738G>C	synonymous_variant	0.69	bedaquiline
lpqB	3625909	c.-999T>C	upstream_gene_variant	0.75	rifampicin
lpqB	3625909	c.-999T>C	upstream_gene_variant	0.75	bedaquiline
mtrB	3625912	c.702G>C	synonymous_variant	0.75	rifampicin
mtrB	3625912	c.702G>C	synonymous_variant	0.75	bedaquiline
mtrB	3625915	c.699G>C	synonymous_variant	0.73	rifampicin
mtrB	3625915	c.699G>C	synonymous_variant	0.73	bedaquiline
mtrB	3625927	c.687T>C	synonymous_variant	0.73	rifampicin
mtrB	3625927	c.687T>C	synonymous_variant	0.73	bedaquiline
mtrB	3626332	c.282T>C	synonymous_variant	1.0	rifampicin
mtrB	3626332	c.282T>C	synonymous_variant	1.0	bedaquiline
mtrB	3626344	c.270G>C	synonymous_variant	1.0	rifampicin
mtrB	3626344	c.270G>C	synonymous_variant	1.0	bedaquiline
mtrB	3626349	p.Ser89Gly	missense_variant	1.0	rifampicin
mtrB	3626349	p.Ser89Gly	missense_variant	1.0	bedaquiline
mtrB	3626353	c.261C>G	synonymous_variant	1.0	rifampicin
mtrB	3626353	c.261C>G	synonymous_variant	1.0	bedaquiline
mtrB	3626362	c.252A>C	synonymous_variant	1.0	rifampicin
mtrB	3626362	c.252A>C	synonymous_variant	1.0	bedaquiline
mtrB	3626368	c.246G>A	synonymous_variant	1.0	rifampicin
mtrB	3626368	c.246G>A	synonymous_variant	1.0	bedaquiline
mtrB	3626377	p.Asp79Glu	missense_variant	1.0	rifampicin
mtrB	3626377	p.Asp79Glu	missense_variant	1.0	bedaquiline
mtrB	3626383	p.Ala77Gly	missense_variant	1.0	rifampicin
mtrB	3626383	p.Ala77Gly	missense_variant	1.0	bedaquiline
mtrB	3626389	p.Arg75Lys	missense_variant	1.0	rifampicin
mtrB	3626389	p.Arg75Lys	missense_variant	1.0	bedaquiline
mtrB	3626400	p.Ile72Val	missense_variant	1.0	rifampicin
mtrB	3626400	p.Ile72Val	missense_variant	1.0	bedaquiline
mtrB	3626404	c.210C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3626404	c.210C>T	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
mtrB	3626407	c.207C>G	synonymous_variant	1.0	rifampicin
mtrB	3626407	c.207C>G	synonymous_variant	1.0	bedaquiline
mtrB	3626437	c.177T>C	synonymous_variant	1.0	rifampicin
mtrB	3626437	c.177T>C	synonymous_variant	1.0	bedaquiline
mtrB	3626443	c.171T>G	synonymous_variant	1.0	rifampicin
mtrB	3626443	c.171T>G	synonymous_variant	1.0	bedaquiline
mtrB	3626451	c.163C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3626451	c.163C>T	synonymous_variant	1.0	bedaquiline
mtrB	3626455	c.159C>G	synonymous_variant	1.0	rifampicin
mtrB	3626455	c.159C>G	synonymous_variant	1.0	bedaquiline
mtrB	3626461	c.153A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3626461	c.153A>G	synonymous_variant	1.0	bedaquiline
mtrB	3626470	c.144A>C	synonymous_variant	1.0	rifampicin
mtrB	3626470	c.144A>C	synonymous_variant	1.0	bedaquiline
mtrB	3626473	c.141T>G	synonymous_variant	0.92	rifampicin
mtrB	3626473	c.141T>G	synonymous_variant	0.92	bedaquiline
mtrB	3626476	c.138C>G	synonymous_variant	0.91	rifampicin
mtrB	3626476	c.138C>G	synonymous_variant	0.91	bedaquiline
mtrB	3626488	c.126C>G	synonymous_variant	0.9	rifampicin
mtrB	3626488	c.126C>G	synonymous_variant	0.9	bedaquiline
mtrB	3626750	c.-137T>C	upstream_gene_variant	0.94	rifampicin
mtrB	3626750	c.-137T>C	upstream_gene_variant	0.94	bedaquiline
mtrA	3626759	c.591T>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
mtrA	3626759	c.591T>C	synonymous_variant	0.94	bedaquiline
mtrB	3626773	c.-160C>T	upstream_gene_variant	0.94	rifampicin
mtrB	3626773	c.-160C>T	upstream_gene_variant	0.94	bedaquiline
mtrB	3626774	c.-163_-161delAGGinsCGC	upstream_gene_variant	0.94	rifampicin
mtrB	3626774	c.-163_-161delAGGinsCGC	upstream_gene_variant	0.94	bedaquiline
mtrA	3626777	c.573C>T	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
mtrA	3626777	c.573C>T	synonymous_variant	0.94	bedaquiline
mtrB	3626780	c.-167T>C	upstream_gene_variant	0.94	rifampicin
mtrB	3626780	c.-167T>C	upstream_gene_variant	0.94	bedaquiline
mtrB	3626783	c.-170C>G	upstream_gene_variant	0.88	rifampicin
mtrB	3626783	c.-170C>G	upstream_gene_variant	0.88	bedaquiline
mtrA	3626786	c.564A>G	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
mtrA	3626786	c.564A>G	synonymous_variant	0.88	bedaquiline
mtrA	3626792	c.558G>T	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
mtrA	3626792	c.558G>T	synonymous_variant	0.88	bedaquiline
mtrB	3626798	c.-185T>A	upstream_gene_variant	0.88	rifampicin
mtrB	3626798	c.-185T>A	upstream_gene_variant	0.88	bedaquiline
mtrA	3626804	c.546A>G	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
mtrA	3626804	c.546A>G	synonymous_variant	0.89	bedaquiline
mtrA	3626825	c.525T>A	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
mtrA	3626825	c.525T>A	synonymous_variant	0.87	bedaquiline
mtrB	3626843	c.-230G>A	upstream_gene_variant	0.86	rifampicin
mtrB	3626843	c.-230G>A	upstream_gene_variant	0.86	bedaquiline
mtrA	3626846	c.504G>A	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
mtrA	3626846	c.504G>A	synonymous_variant	0.86	bedaquiline
mtrB	3626849	c.-236C>T	upstream_gene_variant	0.86	rifampicin
mtrB	3626849	c.-236C>T	upstream_gene_variant	0.86	bedaquiline
mtrB	3626858	c.-245A>G	upstream_gene_variant	0.86	rifampicin
mtrB	3626858	c.-245A>G	upstream_gene_variant	0.86	bedaquiline
mtrB	3626876	c.-263A>G	upstream_gene_variant	0.82	rifampicin
mtrB	3626876	c.-263A>G	upstream_gene_variant	0.82	bedaquiline
mtrB	3626885	c.-272A>G	upstream_gene_variant	0.71	rifampicin
mtrB	3626885	c.-272A>G	upstream_gene_variant	0.71	bedaquiline
mtrB	3626890	c.-277T>C	upstream_gene_variant	0.69	rifampicin
mtrB	3626890	c.-277T>C	upstream_gene_variant	0.69	bedaquiline
mtrB	3626903	c.-290T>C	upstream_gene_variant	0.71	rifampicin
mtrB	3626903	c.-290T>C	upstream_gene_variant	0.71	bedaquiline
mtrA	3626912	c.438T>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
mtrA	3626912	c.438T>C	synonymous_variant	0.71	bedaquiline
mtrB	3626924	c.-311G>C	upstream_gene_variant	0.71	rifampicin
mtrB	3626924	c.-311G>C	upstream_gene_variant	0.71	bedaquiline
mtrB	3626927	c.-314G>A	upstream_gene_variant	0.71	rifampicin
mtrB	3626927	c.-314G>A	upstream_gene_variant	0.71	bedaquiline
mtrB	3626930	c.-317A>G	upstream_gene_variant	0.71	rifampicin
mtrB	3626930	c.-317A>G	upstream_gene_variant	0.71	bedaquiline
mtrB	3626933	c.-320C>T	upstream_gene_variant	0.71	rifampicin
mtrB	3626933	c.-320C>T	upstream_gene_variant	0.71	bedaquiline
mtrB	3626942	c.-329A>C	upstream_gene_variant	0.78	rifampicin
mtrB	3626942	c.-329A>C	upstream_gene_variant	0.78	bedaquiline
mtrB	3626954	c.-341C>G	upstream_gene_variant	0.78	rifampicin
mtrB	3626954	c.-341C>G	upstream_gene_variant	0.78	bedaquiline
mtrB	3626957	c.-344G>C	upstream_gene_variant	0.78	rifampicin
mtrB	3626957	c.-344G>C	upstream_gene_variant	0.78	bedaquiline
mtrB	3626969	c.-356C>G	upstream_gene_variant	0.82	rifampicin
mtrB	3626969	c.-356C>G	upstream_gene_variant	0.82	bedaquiline
mtrB	3626972	c.-359A>G	upstream_gene_variant	0.82	rifampicin
mtrB	3626972	c.-359A>G	upstream_gene_variant	0.82	bedaquiline
mtrB	3626987	c.-374C>G	upstream_gene_variant	0.8	rifampicin
mtrB	3626987	c.-374C>G	upstream_gene_variant	0.8	bedaquiline
mtrB	3626996	c.-383G>A	upstream_gene_variant	0.79	rifampicin
mtrB	3626996	c.-383G>A	upstream_gene_variant	0.79	bedaquiline
mtrB	3627008	c.-395G>C	upstream_gene_variant	0.81	rifampicin
mtrB	3627008	c.-395G>C	upstream_gene_variant	0.81	bedaquiline
mtrB	3627011	c.-398T>G	upstream_gene_variant	0.82	rifampicin
mtrB	3627011	c.-398T>G	upstream_gene_variant	0.82	bedaquiline
mtrB	3627023	c.-410C>G	upstream_gene_variant	0.83	rifampicin
mtrB	3627023	c.-410C>G	upstream_gene_variant	0.83	bedaquiline
mtrB	3627059	c.-446G>C	upstream_gene_variant	0.86	rifampicin
mtrB	3627059	c.-446G>C	upstream_gene_variant	0.86	bedaquiline
mtrA	3627068	c.282T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
mtrA	3627068	c.282T>C	synonymous_variant	0.86	bedaquiline
mtrA	3627080	c.270T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
mtrA	3627080	c.270T>C	synonymous_variant	0.86	bedaquiline
mtrA	3627098	c.252A>C	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
mtrA	3627098	c.252A>C	synonymous_variant	0.87	bedaquiline
mtrB	3627101	c.-488C>G	upstream_gene_variant	0.86	rifampicin
mtrB	3627101	c.-488C>G	upstream_gene_variant	0.86	bedaquiline
mtrB	3627104	c.-491C>G	upstream_gene_variant	0.86	rifampicin
mtrB	3627104	c.-491C>G	upstream_gene_variant	0.86	bedaquiline
mtrB	3627110	c.-497G>C	upstream_gene_variant	0.85	rifampicin
mtrB	3627110	c.-497G>C	upstream_gene_variant	0.85	bedaquiline
mtrB	3627122	c.-509T>C	upstream_gene_variant	0.83	rifampicin
mtrB	3627122	c.-509T>C	upstream_gene_variant	0.83	bedaquiline
mtrB	3627128	c.-515T>C	upstream_gene_variant	0.83	rifampicin
mtrB	3627128	c.-515T>C	upstream_gene_variant	0.83	bedaquiline
mtrB	3627137	c.-526_-524delTTGinsCTA	upstream_gene_variant	0.82	rifampicin
mtrB	3627137	c.-526_-524delTTGinsCTA	upstream_gene_variant	0.82	bedaquiline
mtrA	3627187	c.163T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
mtrA	3627187	c.163T>C	synonymous_variant	0.6	bedaquiline
mtrA	3627188	c.162A>G	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
mtrA	3627188	c.162A>G	synonymous_variant	0.6	bedaquiline
mtrB	3627197	c.-584T>C	upstream_gene_variant	0.6	rifampicin
mtrB	3627197	c.-584T>C	upstream_gene_variant	0.6	bedaquiline
mtrB	3627203	c.-590C>G	upstream_gene_variant	0.73	rifampicin
mtrB	3627203	c.-590C>G	upstream_gene_variant	0.73	bedaquiline
mtrB	3627209	c.-596G>A	upstream_gene_variant	0.73	rifampicin
mtrB	3627209	c.-596G>A	upstream_gene_variant	0.73	bedaquiline
mtrB	3627212	c.-599C>T	upstream_gene_variant	0.73	rifampicin
mtrB	3627212	c.-599C>T	upstream_gene_variant	0.73	bedaquiline
mtrB	3627218	c.-605G>C	upstream_gene_variant	0.79	rifampicin
mtrB	3627218	c.-605G>C	upstream_gene_variant	0.79	bedaquiline
mtrB	3627233	c.-620T>G	upstream_gene_variant	0.8	rifampicin
mtrB	3627233	c.-620T>G	upstream_gene_variant	0.8	bedaquiline
mtrB	3627236	c.-623T>C	upstream_gene_variant	0.79	rifampicin
mtrB	3627236	c.-623T>C	upstream_gene_variant	0.79	bedaquiline
mtrA	3627239	c.111C>T	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
mtrA	3627239	c.111C>T	synonymous_variant	0.81	bedaquiline	Not assoc w R - Interim
mtrB	3627254	c.-641C>T	upstream_gene_variant	0.85	rifampicin
mtrB	3627254	c.-641C>T	upstream_gene_variant	0.85	bedaquiline
mtrB	3627266	c.-653A>G	upstream_gene_variant	0.81	rifampicin
mtrB	3627266	c.-653A>G	upstream_gene_variant	0.81	bedaquiline
mtrB	3627272	c.-659G>C	upstream_gene_variant	0.81	rifampicin
mtrB	3627272	c.-659G>C	upstream_gene_variant	0.81	bedaquiline
mtrB	3627278	c.-665G>T	upstream_gene_variant	0.85	rifampicin
mtrB	3627278	c.-665G>T	upstream_gene_variant	0.85	bedaquiline
mtrB	3627287	c.-674C>G	upstream_gene_variant	0.84	rifampicin
mtrB	3627287	c.-674C>G	upstream_gene_variant	0.84	bedaquiline
mtrB	3627296	c.-683T>G	upstream_gene_variant	0.83	rifampicin
mtrB	3627296	c.-683T>G	upstream_gene_variant	0.83	bedaquiline
mtrB	3627299	c.-688_-686delTTGinsCTC	upstream_gene_variant	0.83	rifampicin
mtrB	3627299	c.-688_-686delTTGinsCTC	upstream_gene_variant	0.83	bedaquiline
mtrB	3627317	c.-704T>C	upstream_gene_variant	0.86	rifampicin
mtrB	3627317	c.-704T>C	upstream_gene_variant	0.86	bedaquiline
mtrA	3627343	p.Thr3Ser	missense_variant	0.9	rifampicin
mtrA	3627343	p.Thr3Ser	missense_variant	0.9	bedaquiline
mtrB	3627359	c.-746T>G	upstream_gene_variant	0.87	rifampicin
mtrB	3627359	c.-746T>G	upstream_gene_variant	0.87	bedaquiline
mtrB	3627360	c.-747G>C	upstream_gene_variant	0.87	rifampicin
mtrB	3627360	c.-747G>C	upstream_gene_variant	0.87	bedaquiline
mtrB	3627375	c.-762C>G	upstream_gene_variant	0.83	rifampicin
mtrB	3627375	c.-762C>G	upstream_gene_variant	0.83	bedaquiline
mtrB	3627377	c.-764G>C	upstream_gene_variant	0.85	rifampicin
mtrB	3627377	c.-764G>C	upstream_gene_variant	0.85	bedaquiline
mtrB	3627380	c.-767T>C	upstream_gene_variant	0.85	rifampicin
mtrB	3627380	c.-767T>C	upstream_gene_variant	0.85	bedaquiline
alr	3840476	c.945A>C	synonymous_variant	0.83	cycloserine
alr	3840502	p.Leu307Val	missense_variant	0.83	cycloserine
alr	3840503	p.Asn306Thr	missense_variant	0.83	cycloserine
alr	3840515	p.Pro302Glu	missense_variant	1.0	cycloserine
alr	3840518	c.903G>C	synonymous_variant	0.91	cycloserine
alr	3840523	p.Ile300Val	missense_variant	0.92	cycloserine
alr	3840527	c.894A>C	synonymous_variant	0.86	cycloserine
alr	3840534	p.Gly296Ala	missense_variant	0.92	cycloserine
alr	3840542	c.879G>A	synonymous_variant	0.88	cycloserine
alr	3840548	c.873G>A	synonymous_variant	0.88	cycloserine
alr	3840551	c.870G>T	synonymous_variant	0.88	cycloserine
alr	3840554	c.867G>C	synonymous_variant	0.88	cycloserine
alr	3840562	p.Ile287Val	missense_variant	0.89	cycloserine
alr	3840566	c.855A>G	synonymous_variant	0.89	cycloserine
alr	3840574	c.847C>T	synonymous_variant	0.84	cycloserine
alr	3840578	c.843T>G	synonymous_variant	0.84	cycloserine
alr	3840599	c.822G>C	synonymous_variant	0.82	cycloserine
alr	3840605	p.Val272Leu	missense_variant	0.79	cycloserine
rpoA	3877494	p.Glu338Asp	missense_variant	0.79	rifampicin	Uncertain significance
rpoA	3877503	c.1005G>C	synonymous_variant	0.8	rifampicin
rpoA	3877506	p.Gly334Ala	missense_variant	0.79	rifampicin
rpoA	3877515	c.993G>C	synonymous_variant	0.87	rifampicin
rpoA	3877557	c.951C>G	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoA	3877587	c.921A>C	synonymous_variant	0.96	rifampicin
rpoA	3877613	p.Ile299Val	missense_variant	0.97	rifampicin
rpoA	3877617	c.891G>C	synonymous_variant	0.96	rifampicin
rpoA	3877638	c.870T>G	synonymous_variant	1.0	rifampicin
rpoA	3877656	c.852T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877677	p.Ala277Ser	missense_variant	0.96	rifampicin
rpoA	3877680	c.828G>C	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoA	3877685	c.823C>T	synonymous_variant	0.97	rifampicin
rpoA	3877686	c.822A>G	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoA	3877692	c.816G>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoA	3877704	c.804G>T	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoA	3877737	c.771G>C	synonymous_variant	0.91	rifampicin
rpoA	3877743	c.765T>C	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoA	3877758	c.750G>C	synonymous_variant	0.91	rifampicin
rpoA	3877764	c.744C>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoA	3877770	c.738A>G	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoA	3877776	c.732T>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoA	3877782	c.726T>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoA	3877815	c.693C>T	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoA	3877839	c.669G>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoA	3877851	c.657C>T	synonymous_variant	0.96	rifampicin
rpoA	3877857	c.651G>A	synonymous_variant	0.96	rifampicin
rpoA	3877865	c.643C>T	synonymous_variant	1.0	rifampicin
rpoA	3877866	c.642G>C	synonymous_variant	1.0	rifampicin
rpoA	3877872	c.636C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877875	c.633T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877887	c.621G>C	synonymous_variant	1.0	rifampicin
rpoA	3877900	p.Ser203Thr	missense_variant	1.0	rifampicin
rpoA	3877905	c.603A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877908	p.Asn200Ser	missense_variant	1.0	rifampicin
rpoA	3877920	c.588G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877962	c.546G>T	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoA	3877968	c.540C>G	synonymous_variant	0.9	rifampicin
rpoA	3877989	c.519A>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoA	3878001	c.507A>G	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoA	3878022	c.486T>C	synonymous_variant	0.87	rifampicin
rpoA	3878025	c.483C>T	synonymous_variant	0.87	rifampicin
rpoA	3878028	c.480G>C	synonymous_variant	0.87	rifampicin
rpoA	3878031	c.477T>C	synonymous_variant	0.87	rifampicin
rpoA	3878043	c.465G>C	synonymous_variant	0.88	rifampicin
rpoA	3878046	c.462T>G	synonymous_variant	0.88	rifampicin
rpoA	3878055	c.453A>G	synonymous_variant	0.88	rifampicin
rpoA	3878061	c.447G>C	synonymous_variant	0.84	rifampicin
rpoA	3878067	c.441C>G	synonymous_variant	0.87	rifampicin
rpoA	3878070	c.438T>C	synonymous_variant	0.87	rifampicin
rpoA	3878082	c.426T>C	synonymous_variant	0.9	rifampicin
rpoA	3878097	c.411G>A	synonymous_variant	0.9	rifampicin
rpoA	3878103	c.405A>G	synonymous_variant	0.87	rifampicin
rpoA	3878106	c.402G>C	synonymous_variant	0.87	rifampicin
rpoA	3878115	c.393G>A	synonymous_variant	0.89	rifampicin
rpoA	3878118	c.390T>C	synonymous_variant	0.89	rifampicin
rpoA	3878130	c.378C>G	synonymous_variant	0.91	rifampicin
rpoA	3878145	c.363C>G	synonymous_variant	0.91	rifampicin
rpoA	3878157	c.351C>G	synonymous_variant	0.9	rifampicin
rpoA	3878166	c.342C>G	synonymous_variant	0.9	rifampicin
rpoA	3878169	c.339G>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoA	3878184	c.324C>T	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoA	3878187	c.321C>G	synonymous_variant	0.96	rifampicin
rpoA	3878193	c.315T>C	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoA	3878205	c.303T>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoA	3878217	c.291A>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoA	3878229	c.279C>G	synonymous_variant	0.93	rifampicin
rpoA	3878247	c.261G>C	synonymous_variant	0.91	rifampicin
rpoA	3878256	c.252G>C	synonymous_variant	0.94	rifampicin
rpoA	3878264	p.Ser82Gly	missense_variant	0.91	rifampicin
rpoA	3878271	c.237T>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoA	3878283	p.Glu75Asp	missense_variant	0.94	rifampicin	Uncertain significance
rpoA	3878295	c.213A>G	synonymous_variant	0.95	rifampicin
rpoA	3878298	c.210A>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoA	3878304	c.204G>C	synonymous_variant	0.93	rifampicin
rpoA	3878313	c.195G>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoA	3878322	c.186A>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoA	3878331	c.177A>C	synonymous_variant	0.94	rifampicin
rpoA	3878334	c.174T>C	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoA	3878337	c.171T>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoA	3878346	c.162T>C	synonymous_variant	0.95	rifampicin
rpoA	3878364	c.144A>C	synonymous_variant	0.94	rifampicin
rpoA	3878370	c.138T>C	synonymous_variant	0.92	rifampicin
rpoA	3878376	c.132G>C	synonymous_variant	0.92	rifampicin
rpoA	3878384	c.124C>T	synonymous_variant	0.91	rifampicin
rpoA	3878385	c.123C>G	synonymous_variant	0.91	rifampicin
rpoA	3878391	c.117T>G	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoA	3878418	c.90C>T	synonymous_variant	0.9	rifampicin
rpoA	3878442	c.66G>C	synonymous_variant	0.87	rifampicin
rpoA	3878454	c.54A>G	synonymous_variant	0.81	rifampicin
rpoA	3878458	p.Asn17Ser	missense_variant	0.83	rifampicin
rpoA	3878471	p.Val13Leu	missense_variant	0.78	rifampicin
rpoA	3878472	p.Asp12Glu	missense_variant	0.77	rifampicin
rpoA	3878484	c.24C>A	synonymous_variant	0.7	rifampicin
rpoA	3878490	c.18C>A	synonymous_variant	0.72	rifampicin
rpoA	3878496	c.12A>T	synonymous_variant	0.69	rifampicin
rpoA	3878761	c.-254G>A	upstream_gene_variant	0.7	rifampicin	Uncertain significance
rpoA	3878764	c.-257A>G	upstream_gene_variant	0.7	rifampicin
rpoA	3878776	c.-269G>C	upstream_gene_variant	0.7	rifampicin
rpoA	3878779	c.-274_-272delATCinsGTT	upstream_gene_variant	0.7	rifampicin
rpoA	3878788	c.-281G>T	upstream_gene_variant	0.7	rifampicin
rpoA	3878803	c.-296G>C	upstream_gene_variant	0.75	rifampicin	Uncertain significance
rpoA	3878809	c.-302T>C	upstream_gene_variant	0.75	rifampicin
rpoA	3878824	c.-317G>C	upstream_gene_variant	0.86	rifampicin
rpoA	3878833	c.-326C>G	upstream_gene_variant	0.9	rifampicin
rpoA	3878836	c.-329G>C	upstream_gene_variant	0.9	rifampicin	Uncertain significance
rpoA	3878842	c.-335G>C	upstream_gene_variant	0.91	rifampicin
rpoA	3878853	c.-346G>A	upstream_gene_variant	0.92	rifampicin
rpoA	3878869	c.-362G>C	upstream_gene_variant	0.91	rifampicin
rpoA	3878878	c.-371T>C	upstream_gene_variant	0.91	rifampicin	Uncertain significance
rpoA	3878881	c.-374C>G	upstream_gene_variant	0.91	rifampicin
rpoA	3878889	c.-382A>G	upstream_gene_variant	0.89	rifampicin
rpoA	3878894	c.-387A>G	upstream_gene_variant	0.9	rifampicin
rpoA	3878909	c.-402A>C	upstream_gene_variant	0.92	rifampicin
rpoA	3878914	c.-407T>C	upstream_gene_variant	0.92	rifampicin	Uncertain significance
rpoA	3878923	c.-417_-416delGCinsCG	upstream_gene_variant	0.92	rifampicin
rpoA	3878947	c.-440G>C	upstream_gene_variant	0.86	rifampicin	Uncertain significance
rpoA	3878953	c.-446C>G	upstream_gene_variant	0.87	rifampicin
rpoA	3878962	c.-455G>A	upstream_gene_variant	0.81	rifampicin	Uncertain significance
rpoA	3878968	c.-461T>C	upstream_gene_variant	0.87	rifampicin	Uncertain significance
rpoA	3878974	c.-469_-467delATCinsGTG	upstream_gene_variant	0.86	rifampicin
rpoA	3879117	c.-610C>T	upstream_gene_variant	0.86	rifampicin
rpoA	3879121	c.-614T>G	upstream_gene_variant	0.85	rifampicin
rpoA	3879127	c.-620T>C	upstream_gene_variant	0.86	rifampicin
rpoA	3879145	c.-638G>C	upstream_gene_variant	0.82	rifampicin
rpoA	3879148	c.-641G>C	upstream_gene_variant	0.82	rifampicin
rpoA	3879154	c.-647T>C	upstream_gene_variant	0.82	rifampicin
rpoA	3879160	c.-653A>G	upstream_gene_variant	0.82	rifampicin
rpoA	3879178	c.-671T>G	upstream_gene_variant	0.74	rifampicin
rpoA	3879190	c.-683C>G	upstream_gene_variant	0.7	rifampicin
rpoA	3879202	c.-695T>C	upstream_gene_variant	0.7	rifampicin
rpoA	3879208	c.-701C>G	upstream_gene_variant	0.71	rifampicin
rpoA	3879222	c.-715T>C	upstream_gene_variant	0.71	rifampicin
rpoA	3879226	c.-719G>C	upstream_gene_variant	0.71	rifampicin
rpoA	3879229	c.-722A>G	upstream_gene_variant	0.79	rifampicin
rpoA	3879232	c.-725A>G	upstream_gene_variant	0.79	rifampicin
clpC1	4038329	p.Glu792Asp	missense_variant	0.9	pyrazinamide
clpC1	4038338	c.2367C>T	synonymous_variant	0.92	pyrazinamide
clpC1	4038347	c.2358G>C	synonymous_variant	0.92	pyrazinamide
clpC1	4038356	c.2349T>C	synonymous_variant	0.94	pyrazinamide
clpC1	4038359	c.2346A>G	synonymous_variant	0.94	pyrazinamide
clpC1	4038368	c.2337T>C	synonymous_variant	0.94	pyrazinamide
clpC1	4038388	c.2317T>C	synonymous_variant	0.95	pyrazinamide
clpC1	4038398	c.2307G>T	synonymous_variant	0.96	pyrazinamide
clpC1	4038403	c.2302T>C	synonymous_variant	0.96	pyrazinamide	Not assoc w R - Interim
clpC1	4038425	c.2280C>A	synonymous_variant	0.97	pyrazinamide
clpC1	4038444	p.Ala754Lys	missense_variant	0.97	pyrazinamide
clpC1	4038446	c.2259T>C	synonymous_variant	0.97	pyrazinamide
clpC1	4038456	p.Val750Glu	missense_variant	1.0	pyrazinamide
clpC1	4038486	p.Gly740Asn	missense_variant	1.0	pyrazinamide
clpC1	4038491	c.2214C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4038502	p.Ile735Val	missense_variant	1.0	pyrazinamide
clpC1	4038508	c.2197C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4038518	c.2187G>T	synonymous_variant	1.0	pyrazinamide
clpC1	4038530	p.Glu725Asp	missense_variant	0.97	pyrazinamide
clpC1	4038537	p.Thr723Ser	missense_variant	0.96	pyrazinamide
clpC1	4038539	c.2166G>C	synonymous_variant	0.96	pyrazinamide
clpC1	4038569	c.2136C>T	synonymous_variant	0.95	pyrazinamide
clpC1	4038575	c.2130C>G	synonymous_variant	0.95	pyrazinamide
clpC1	4038596	c.2109A>G	synonymous_variant	0.95	pyrazinamide
clpC1	4038620	c.2085G>A	synonymous_variant	0.95	pyrazinamide
clpC1	4038623	c.2082A>G	synonymous_variant	0.95	pyrazinamide
clpC1	4038653	c.2052C>T	synonymous_variant	0.94	pyrazinamide
clpC1	4038658	p.Lys683Gln	missense_variant	0.89	pyrazinamide
clpC1	4038661	p.Ser682Thr	missense_variant	0.88	pyrazinamide
clpC1	4038662	c.2043T>C	synonymous_variant	0.89	pyrazinamide
clpC1	4038668	c.2037G>C	synonymous_variant	0.89	pyrazinamide
clpC1	4038671	c.2034T>C	synonymous_variant	0.89	pyrazinamide
clpC1	4038677	c.2028G>C	synonymous_variant	0.94	pyrazinamide
clpC1	4038683	c.2022T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4038692	c.2013C>G	synonymous_variant	0.94	pyrazinamide	Not assoc w R - Interim
clpC1	4038713	c.1992T>C	synonymous_variant	0.94	pyrazinamide
clpC1	4038740	c.1965G>C	synonymous_variant	0.91	pyrazinamide
clpC1	4038749	c.1956C>T	synonymous_variant	0.91	pyrazinamide	Not assoc w R - Interim
clpC1	4038773	c.1932T>C	synonymous_variant	0.89	pyrazinamide
clpC1	4038782	c.1923G>T	synonymous_variant	0.88	pyrazinamide
clpC1	4038790	c.1915C>T	synonymous_variant	0.88	pyrazinamide	Not assoc w R - Interim
clpC1	4038809	c.1896G>A	synonymous_variant	0.96	pyrazinamide
clpC1	4038812	c.1893T>C	synonymous_variant	0.96	pyrazinamide
clpC1	4038875	c.1830C>G	synonymous_variant	0.89	pyrazinamide
clpC1	4038878	c.1827A>G	synonymous_variant	0.89	pyrazinamide	Not assoc w R - Interim
clpC1	4038893	c.1812C>T	synonymous_variant	0.93	pyrazinamide
clpC1	4038908	c.1797C>G	synonymous_variant	0.93	pyrazinamide
clpC1	4038914	c.1791G>C	synonymous_variant	0.93	pyrazinamide
clpC1	4038923	c.1782A>G	synonymous_variant	0.93	pyrazinamide
clpC1	4038953	c.1752A>G	synonymous_variant	0.92	pyrazinamide
clpC1	4038956	c.1749T>C	synonymous_variant	0.92	pyrazinamide
clpC1	4038965	c.1740T>C	synonymous_variant	0.88	pyrazinamide
clpC1	4038971	c.1734T>C	synonymous_variant	0.9	pyrazinamide
clpC1	4038974	c.1731T>C	synonymous_variant	0.9	pyrazinamide	Not assoc w R - Interim
clpC1	4038989	c.1716T>C	synonymous_variant	0.93	pyrazinamide
clpC1	4038997	c.1708T>C	synonymous_variant	0.88	pyrazinamide	Not assoc w R - Interim
clpC1	4039004	c.1701C>G	synonymous_variant	0.88	pyrazinamide
clpC1	4039022	c.1683A>G	synonymous_variant	0.95	pyrazinamide
clpC1	4039025	c.1680C>G	synonymous_variant	0.94	pyrazinamide
clpC1	4039223	c.1482C>T	synonymous_variant	0.73	pyrazinamide
clpC1	4039226	c.1479T>C	synonymous_variant	0.72	pyrazinamide	Not assoc w R - Interim
clpC1	4039238	c.1467C>T	synonymous_variant	0.76	pyrazinamide
clpC1	4039243	c.1462C>T	synonymous_variant	0.75	pyrazinamide
clpC1	4039259	c.1446G>A	synonymous_variant	0.78	pyrazinamide
clpC1	4039262	c.1443C>T	synonymous_variant	0.78	pyrazinamide	Not assoc w R - Interim
clpC1	4039268	c.1437C>T	synonymous_variant	0.78	pyrazinamide
clpC1	4039274	c.1431G>C	synonymous_variant	0.8	pyrazinamide	Not assoc w R - Interim
clpC1	4039286	c.1419T>C	synonymous_variant	0.79	pyrazinamide
clpC1	4039298	c.1407T>C	synonymous_variant	0.79	pyrazinamide
clpC1	4039304	c.1401G>A	synonymous_variant	0.79	pyrazinamide
clpC1	4039313	c.1392C>T	synonymous_variant	0.79	pyrazinamide
clpC1	4039319	p.Ala462Thr	missense_variant	0.78	pyrazinamide
clpC1	4039322	c.1383T>C	synonymous_variant	0.76	pyrazinamide
clpC1	4039328	c.1377A>C	synonymous_variant	0.81	pyrazinamide
clpC1	4039338	p.Thr456Gln	missense_variant	0.82	pyrazinamide
clpC1	4039361	c.1344C>A	synonymous_variant	0.77	pyrazinamide
clpC1	4039382	c.1323C>T	synonymous_variant	0.67	pyrazinamide	Not assoc w R - Interim
clpC1	4039463	c.1242C>G	synonymous_variant	0.6	pyrazinamide
clpC1	4039466	c.1239T>C	synonymous_variant	0.6	pyrazinamide
clpC1	4039469	c.1236T>C	synonymous_variant	0.6	pyrazinamide
clpC1	4039472	c.1233G>C	synonymous_variant	0.6	pyrazinamide
clpC1	4039481	c.1224T>G	synonymous_variant	0.77	pyrazinamide	Not assoc w R - Interim
clpC1	4039484	c.1221T>G	synonymous_variant	0.75	pyrazinamide
clpC1	4039508	c.1197G>C	synonymous_variant	0.84	pyrazinamide
clpC1	4039526	c.1179G>A	synonymous_variant	0.88	pyrazinamide
clpC1	4039532	c.1173C>T	synonymous_variant	0.93	pyrazinamide
clpC1	4039553	c.1152C>A	synonymous_variant	0.97	pyrazinamide
clpC1	4039562	c.1143C>G	synonymous_variant	0.97	pyrazinamide
clpC1	4039565	c.1140G>C	synonymous_variant	0.97	pyrazinamide
clpC1	4039576	p.Ala377Ser	missense_variant	0.97	pyrazinamide
clpC1	4039577	c.1128T>C	synonymous_variant	0.97	pyrazinamide	Not assoc w R - Interim
clpC1	4039583	c.1122C>T	synonymous_variant	0.94	pyrazinamide
clpC1	4039622	c.1083C>T	synonymous_variant	0.94	pyrazinamide
clpC1	4039664	c.1041G>C	synonymous_variant	0.81	pyrazinamide
clpC1	4039670	c.1035G>C	synonymous_variant	0.76	pyrazinamide
clpC1	4039796	c.909C>T	synonymous_variant	0.71	pyrazinamide	Not assoc w R - Interim
clpC1	4039805	c.900C>G	synonymous_variant	0.73	pyrazinamide
clpC1	4039817	c.888A>T	synonymous_variant	0.79	pyrazinamide
clpC1	4039820	c.885T>C	synonymous_variant	0.79	pyrazinamide	Not assoc w R - Interim
clpC1	4039826	c.879C>G	synonymous_variant	0.85	pyrazinamide
clpC1	4039831	c.874T>C	synonymous_variant	0.85	pyrazinamide
clpC1	4039832	c.873C>T	synonymous_variant	0.85	pyrazinamide
clpC1	4039850	c.855T>C	synonymous_variant	0.88	pyrazinamide
clpC1	4039865	c.840T>C	synonymous_variant	0.92	pyrazinamide
clpC1	4039898	c.807C>G	synonymous_variant	0.93	pyrazinamide
clpC1	4039931	c.774T>C	synonymous_variant	0.94	pyrazinamide
clpC1	4039937	c.768G>C	synonymous_variant	0.94	pyrazinamide
clpC1	4039943	c.762G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039946	c.759A>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039949	c.756G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039952	c.753T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039955	c.750G>T	synonymous_variant	1.0	pyrazinamide
clpC1	4039958	c.747G>C	synonymous_variant	0.92	pyrazinamide
clpC1	4039964	c.741C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4040090	c.613_615delTCTinsAGC	synonymous_variant	0.93	pyrazinamide
clpC1	4040093	c.612C>G	synonymous_variant	0.93	pyrazinamide	Not assoc w R - Interim
clpC1	4040105	c.600C>G	synonymous_variant	0.94	pyrazinamide
clpC1	4040147	c.558A>G	synonymous_variant	0.96	pyrazinamide	Not assoc w R - Interim
clpC1	4040162	c.543G>C	synonymous_variant	0.97	pyrazinamide	Not assoc w R - Interim
clpC1	4040165	c.540G>C	synonymous_variant	0.97	pyrazinamide
clpC1	4040171	c.534C>G	synonymous_variant	0.97	pyrazinamide
clpC1	4040195	c.510G>T	synonymous_variant	0.96	pyrazinamide
clpC1	4040200	c.505T>C	synonymous_variant	0.95	pyrazinamide
clpC1	4040201	c.504C>G	synonymous_variant	0.95	pyrazinamide
clpC1	4040204	c.501G>C	synonymous_variant	0.95	pyrazinamide
clpC1	4040207	c.498T>C	synonymous_variant	0.95	pyrazinamide
clpC1	4040213	c.490_492delTCTinsAGC	synonymous_variant	0.95	pyrazinamide
clpC1	4040225	c.480A>C	synonymous_variant	0.95	pyrazinamide
clpC1	4040228	c.477G>C	synonymous_variant	0.95	pyrazinamide
clpC1	4040231	c.474C>T	synonymous_variant	0.95	pyrazinamide
clpC1	4040246	c.459C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040249	c.456A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040267	c.438A>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040273	c.432T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040291	c.414G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040309	c.396C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4040342	c.363C>G	synonymous_variant	0.84	pyrazinamide
clpC1	4040348	c.357G>C	synonymous_variant	0.84	pyrazinamide
clpC1	4040354	c.351A>G	synonymous_variant	0.84	pyrazinamide
clpC1	4040357	c.348T>C	synonymous_variant	0.84	pyrazinamide
clpC1	4040363	c.342A>C	synonymous_variant	0.84	pyrazinamide
clpC1	4040369	c.336C>G	synonymous_variant	0.84	pyrazinamide
clpC1	4040375	c.330G>C	synonymous_variant	0.84	pyrazinamide
clpC1	4040380	c.325T>C	synonymous_variant	0.85	pyrazinamide
clpC1	4040387	c.318A>G	synonymous_variant	0.83	pyrazinamide
clpC1	4040393	c.312G>C	synonymous_variant	0.83	pyrazinamide	Not assoc w R - Interim
clpC1	4040411	c.294T>C	synonymous_variant	0.86	pyrazinamide	Not assoc w R - Interim
clpC1	4040419	c.286C>T	synonymous_variant	0.86	pyrazinamide
clpC1	4040423	c.282A>G	synonymous_variant	0.9	pyrazinamide	Not assoc w R - Interim
clpC1	4040426	c.279T>C	synonymous_variant	0.86	pyrazinamide
clpC1	4040431	c.274T>C	synonymous_variant	0.78	pyrazinamide
clpC1	4040450	c.255A>G	synonymous_variant	0.75	pyrazinamide	Not assoc w R - Interim
panD	4045000	c.-719A>T	upstream_gene_variant	0.77	pyrazinamide
panD	4045001	c.-720G>C	upstream_gene_variant	0.77	pyrazinamide
panD	4045022	c.-742_-741delTCinsCG	upstream_gene_variant	0.71	pyrazinamide
panD	4045028	c.-747C>G	upstream_gene_variant	0.67	pyrazinamide
panD	4045034	c.-753A>G	upstream_gene_variant	0.67	pyrazinamide
panD	4045052	c.-771G>C	upstream_gene_variant	0.59	pyrazinamide
panD	4045063	c.-782T>C	upstream_gene_variant	0.62	pyrazinamide
panD	4045067	c.-786C>G	upstream_gene_variant	0.62	pyrazinamide
panD	4045070	c.-789C>T	upstream_gene_variant	0.62	pyrazinamide
panD	4045073	c.-792C>G	upstream_gene_variant	0.62	pyrazinamide
panD	4045076	c.-795A>C	upstream_gene_variant	0.62	pyrazinamide
panD	4045088	c.-807T>G	upstream_gene_variant	0.62	pyrazinamide
panD	4045094	c.-813T>G	upstream_gene_variant	0.57	pyrazinamide
panD	4045097	c.-816T>G	upstream_gene_variant	0.57	pyrazinamide
panD	4045105	c.-824T>C	upstream_gene_variant	0.62	pyrazinamide
glpK	4138340	c.1416G>C	synonymous_variant	0.8	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138352	c.1404C>G	synonymous_variant	0.64	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138360	c.1396T>C	synonymous_variant	0.64	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138370	c.1386C>T	synonymous_variant	0.64	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138376	p.Val460Ala	missense_variant	0.64	levofloxacin	Not assoc w R
					moxifloxacin	Not assoc w R
					isoniazid	Not assoc w R
					streptomycin	Not assoc w R
					rifampicin	Not assoc w R
					ethambutol	Not assoc w R
glpK	4138379	c.1377T>C	synonymous_variant	0.64	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138382	c.1374A>G	synonymous_variant	0.64	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138385	c.1371A>G	synonymous_variant	0.64	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138397	c.1359C>G	synonymous_variant	0.7	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138418	c.1338T>C	synonymous_variant	0.67	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138427	c.1327_1329delTTGinsCTC	synonymous_variant	0.6	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138433	c.1323C>T	synonymous_variant	0.6	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138596	p.Phe387Tyr	missense_variant	0.73	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138598	c.1158G>C	synonymous_variant	0.73	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138606	c.1150T>C	synonymous_variant	0.78	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138631	c.1125C>G	synonymous_variant	0.88	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138640	c.1116C>T	synonymous_variant	0.88	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138643	c.1113A>G	synonymous_variant	0.88	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4138646	c.1110G>C	synonymous_variant	0.89	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138670	c.1086G>C	synonymous_variant	0.87	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138681	p.Met359Val	missense_variant	0.89	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138682	c.1074C>G	synonymous_variant	0.89	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138702	p.Gln352Glu	missense_variant	0.88	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138703	c.1053C>T	synonymous_variant	0.88	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138706	c.1050C>G	synonymous_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138714	p.Ala348Ser	missense_variant	0.96	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138715	c.1041G>A	synonymous_variant	0.96	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138718	c.1038T>C	synonymous_variant	0.96	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138724	c.1032A>G	synonymous_variant	0.96	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138751	c.1005T>C	synonymous_variant	0.89	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138757	c.999A>G	synonymous_variant	0.84	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139176	p.Val194Ile	missense_variant	0.8	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139177	c.579T>C	synonymous_variant	0.8	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139215	c.541T>C	synonymous_variant	0.85	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139223	p.Thr178Ser	missense_variant	0.85	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139230	p.Pro176Ala	missense_variant	0.85	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139231	c.525A>C	synonymous_variant	0.85	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139243	c.513A>G	synonymous_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139249	c.507C>T	synonymous_variant	0.92	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
embC	4240671	p.Thr270Ile	missense_variant	0.73	ethambutol	Not assoc w R
embC	4240678	c.816T>C	synonymous_variant	0.75	ethambutol
embC	4240681	c.819G>C	synonymous_variant	0.75	ethambutol
embC	4240685	p.Thr275Ala	missense_variant	0.8	ethambutol
embC	4240690	c.828G>C	synonymous_variant	0.8	ethambutol
embC	4240693	c.831T>C	synonymous_variant	0.8	ethambutol
embC	4240698	p.Ala279Gly	missense_variant	0.8	ethambutol
embC	4240726	c.864G>C	synonymous_variant	0.82	ethambutol	Not assoc w R - Interim
embC	4240729	c.867C>G	synonymous_variant	0.82	ethambutol
embC	4240747	c.885C>T	synonymous_variant	0.82	ethambutol	Not assoc w R - Interim
embC	4240759	c.897C>G	synonymous_variant	0.82	ethambutol
embC	4240765	c.903C>G	synonymous_variant	0.82	ethambutol
embC	4240783	c.921G>C	synonymous_variant	0.76	ethambutol
embB	4247407	c.894G>C	synonymous_variant	0.9	ethambutol
embB	4247425	c.912G>C	synonymous_variant	0.94	ethambutol
embB	4247437	c.924A>G	synonymous_variant	0.9	ethambutol	Not assoc w R - Interim
embB	4247452	c.939C>G	synonymous_variant	0.92	ethambutol
embB	4247470	c.957T>C	synonymous_variant	0.97	ethambutol
embB	4247497	c.984T>C	synonymous_variant	0.96	ethambutol
embB	4247500	c.987C>G	synonymous_variant	0.96	ethambutol
embB	4247506	c.993C>G	synonymous_variant	0.96	ethambutol
embB	4247512	c.999T>C	synonymous_variant	0.96	ethambutol
embB	4247527	c.1014G>C	synonymous_variant	0.96	ethambutol
embB	4247539	c.1026T>C	synonymous_variant	0.96	ethambutol
embB	4247550	p.Ala346Asp	missense_variant	0.96	ethambutol
embB	4247554	c.1041T>C	synonymous_variant	0.96	ethambutol
embB	4247566	c.1053C>G	synonymous_variant	0.94	ethambutol
embB	4247572	c.1059A>C	synonymous_variant	0.92	ethambutol
embB	4247590	c.1077A>G	synonymous_variant	0.96	ethambutol	Not assoc w R - Interim
embB	4247629	c.1116C>G	synonymous_variant	0.94	ethambutol
embB	4247632	c.1119C>G	synonymous_variant	0.91	ethambutol
embB	4247638	c.1125G>C	synonymous_variant	0.91	ethambutol
embB	4247645	p.Glu378Thr	missense_variant	0.87	ethambutol
embB	4247648	p.Ala379Ser	missense_variant	0.91	ethambutol
embB	4247656	c.1143A>G	synonymous_variant	0.91	ethambutol
embB	4247657	p.Pro382Ala	missense_variant	0.91	ethambutol
embB	4247662	c.1149C>G	synonymous_variant	0.92	ethambutol
embB	4247677	c.1164C>G	synonymous_variant	0.92	ethambutol	Not assoc w R - Interim
embB	4247684	c.1171T>C	synonymous_variant	0.92	ethambutol
embB	4248070	c.1557T>C	synonymous_variant	0.7	ethambutol
embB	4248085	c.1572T>C	synonymous_variant	0.79	ethambutol
embB	4248097	c.1584C>G	synonymous_variant	0.84	ethambutol
embB	4248118	c.1605T>G	synonymous_variant	0.86	ethambutol
embB	4248127	c.1614G>C	synonymous_variant	0.86	ethambutol
embB	4248130	c.1617G>C	synonymous_variant	0.86	ethambutol
embB	4248133	c.1620C>A	synonymous_variant	0.82	ethambutol
embB	4248139	c.1626C>G	synonymous_variant	0.78	ethambutol
embB	4248142	c.1629T>C	synonymous_variant	0.78	ethambutol
embB	4248143	c.1630T>C	synonymous_variant	0.78	ethambutol
embB	4248146	p.Ile545Leu	missense_variant	0.78	ethambutol
embB	4248149	p.Thr546Ser	missense_variant	0.78	ethambutol
embB	4248157	c.1644A>G	synonymous_variant	0.83	ethambutol	Not assoc w R - Interim
embB	4248161	c.1648C>T	synonymous_variant	0.83	ethambutol	Not assoc w R - Interim
embB	4248169	c.1656C>G	synonymous_variant	0.86	ethambutol
embB	4248190	c.1677G>C	synonymous_variant	0.83	ethambutol	Not assoc w R - Interim
embB	4248200	p.Ile563Val	missense_variant	0.81	ethambutol
embB	4248206	p.Ser565Gly	missense_variant	0.8	ethambutol	Uncertain significance
embB	4248211	c.1698G>A	synonymous_variant	0.78	ethambutol

TB-Profiler result