TB-Profiler result

Run: SRR12708418
Summary

Run ID: SRR12708418

Sample name:

Date: 2024-04-14T05:54:03.343769

Number of reads: 647235

Percentage reads mapped: 39.53

Median coverage: 16.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG p.Met257Ile Uncertain significance Mutation from literature
ethambutol
pyrazinamide
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpsL 781687 p.Lys43Arg missense_variant 0.64 streptomycin Assoc w R
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethionamide Assoc w R Alias fabG1_c.-15C>T
katG 2155341 p.Met257Ile missense_variant 1.0 isoniazid Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6700 c.-602T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6749 p.Ala504Ser missense_variant 0.22 levofloxacin
moxifloxacin
gyrB 6764 c.1525_1527delCTGinsTC frameshift_variant&missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin
gyrB 6772 c.1533C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6976 c.-326A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7012 c.1773G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7021 c.-281G>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7022 p.Leu595Val missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 7025 p.Lys596Ala missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7581 p.Asp94Ser missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
fgd1 490988 p.Leu69Gln missense_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 490992 c.210G>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 490998 c.216T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491005 p.Leu75Met missense_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fgd1 491037 c.255C>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fgd1 491112 c.330G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491115 c.333G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 1.0 ethionamide Not assoc w R
isoniazid Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.36 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.33 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.32 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.31 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.28 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.43 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.45 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
nusG 734502 c.249G>A synonymous_variant 0.51 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.41 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.45 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
nusG 734807 p.Tyr185Phe missense_variant 0.47 rifampicin
nusG 734814 c.561G>C synonymous_variant 0.38 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.41 rifampicin
nusG 734841 c.588G>C synonymous_variant 0.35 rifampicin
nusG 734844 c.591G>C synonymous_variant 0.33 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.37 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.37 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.37 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.37 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.37 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.3 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.3 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.32 rifampicin
nusG 734898 c.645C>G synonymous_variant 0.32 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.36 rifampicin Uncertain significance
rpoB 760143 p.Val113Ile missense_variant 0.29 rifampicin Uncertain significance
rpoB 760148 p.Asp114Glu missense_variant 0.31 rifampicin
rpoB 760157 c.351A>G synonymous_variant 0.32 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.37 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.48 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760187 c.381G>C synonymous_variant 0.43 rifampicin
rpoB 760196 c.390C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.43 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760400 c.594G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.21 rifampicin
rpoB 760407 c.601_603delAGCinsGT frameshift_variant&missense_variant 0.34 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760461 p.Arg219Ser missense_variant 0.54 rifampicin Uncertain significance
rpoB 760475 c.669A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760532 c.726T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.37 rifampicin
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.42 rifampicin
rpoB 760649 c.843G>C synonymous_variant 0.18 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760659 c.853_855delTCAinsAGC synonymous_variant 0.19 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760858 p.Val351Ala missense_variant 0.3 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760865 c.1059C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760883 c.1077G>C synonymous_variant 0.28 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.37 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.52 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.47 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.52 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.55 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760958 c.1152G>C synonymous_variant 0.68 rifampicin
rpoB 760961 c.1155C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.74 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.79 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761087 c.1281C>G synonymous_variant 0.52 rifampicin
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.52 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.68 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.7 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.62 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>C synonymous_variant 0.7 rifampicin
rpoB 761261 c.1455G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.53 rifampicin
rpoB 761285 c.1479G>C synonymous_variant 0.5 rifampicin
rpoB 761288 c.1482G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761540 c.1734C>A synonymous_variant 0.45 rifampicin
rpoB 761549 c.1743G>C synonymous_variant 0.45 rifampicin
rpoB 761555 c.1749G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.48 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.5 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.5 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761951 c.2145G>C synonymous_variant 0.39 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.39 rifampicin Uncertain significance
rpoB 762002 c.2196C>G synonymous_variant 0.53 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.52 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762026 c.2220G>C synonymous_variant 0.62 rifampicin
rpoB 762029 c.2223C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.55 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762098 c.2292C>G synonymous_variant 0.52 rifampicin
rpoB 762110 c.2304G>C synonymous_variant 0.39 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.53 rifampicin Uncertain significance
rpoB 762140 c.2334G>C synonymous_variant 0.46 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.46 rifampicin
rpoB 762158 c.2352G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.3 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.35 rifampicin
rpoB 762293 c.2487T>G synonymous_variant 0.32 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762318 p.Ser838Asn missense_variant 0.35 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762335 c.2529C>T synonymous_variant 0.33 rifampicin
rpoB 762338 c.2532T>C synonymous_variant 0.41 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762881 p.Met1025Ile missense_variant 0.38 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 762917 c.-453C>T upstream_gene_variant 0.39 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 762926 c.-444C>G upstream_gene_variant 0.38 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.4 rifampicin
rpoC 762956 c.-414G>C upstream_gene_variant 0.35 rifampicin
rpoB 762959 c.3153G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>A upstream_gene_variant 0.35 rifampicin
rpoB 762989 c.3183G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.54 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763052 c.-318G>C upstream_gene_variant 0.33 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.32 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.23 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.23 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.22 rifampicin
rpoB 763172 c.3366G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763375 c.6C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>C synonymous_variant 0.3 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763423 p.Glu18Asp missense_variant 0.33 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCC frameshift_variant&missense_variant 0.36 rifampicin
rpoC 763433 c.64_66delCAAinsAC frameshift_variant&missense_variant 0.36 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763507 c.138G>C synonymous_variant 0.45 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>G synonymous_variant 0.59 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>T synonymous_variant 0.65 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.72 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.71 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.67 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.64 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.65 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.58 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.55 rifampicin
rpoC 763786 c.417C>G synonymous_variant 0.53 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.49 rifampicin
rpoC 763796 c.427_429delATGinsCC frameshift_variant&missense_variant 0.46 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.37 rifampicin
rpoC 763819 c.450G>C synonymous_variant 0.33 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.29 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763910 c.541_543delCTGinsAC frameshift_variant&missense_variant 0.24 rifampicin
rpoC 763921 c.552G>C synonymous_variant 0.24 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.31 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.3 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.31 rifampicin Uncertain significance
rpoC 763951 c.582G>T synonymous_variant 0.26 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763961 p.Arg198Lys missense_variant 0.23 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.32 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.35 rifampicin
rpoC 764039 c.670_671delAGinsTC synonymous_variant 0.22 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.24 rifampicin
rpoC 764059 c.690G>A synonymous_variant 0.24 rifampicin
rpoC 764062 c.693C>G synonymous_variant 0.23 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764149 c.780G>C synonymous_variant 0.28 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.24 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.27 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.27 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.27 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.27 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.26 rifampicin
rpoC 764239 c.870T>C synonymous_variant 0.3 rifampicin
rpoC 764254 c.885G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.22 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.17 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.17 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.17 rifampicin
rpoC 764275 c.909_911delACA disruptive_inframe_deletion 0.18 rifampicin
rpoC 764284 c.915delGinsCACC conservative_inframe_insertion&synonymous_variant 0.18 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.25 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.24 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.46 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 0.38 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.43 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764707 c.1338G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.35 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.34 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.34 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.48 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.48 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764844 p.Ala492Gly missense_variant 0.35 rifampicin
rpoC 764854 c.1485G>C synonymous_variant 0.39 rifampicin
rpoC 764858 c.1489_1491delTTGinsCC frameshift_variant&missense_variant 0.56 rifampicin
rpoC 764872 c.1503A>C synonymous_variant 0.36 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.28 rifampicin
rpoC 764887 c.1518G>T synonymous_variant 0.27 rifampicin
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.41 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.23 rifampicin
rpoC 764902 c.1533C>G synonymous_variant 0.22 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.42 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.42 rifampicin Uncertain significance
rpoC 764917 c.1548G>C synonymous_variant 0.25 rifampicin
rpoC 764920 c.1551G>C synonymous_variant 0.25 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766309 c.2940G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>C synonymous_variant 0.5 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.5 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.56 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.58 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.62 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.62 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.61 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>A synonymous_variant 0.31 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767017 c.3648C>G synonymous_variant 0.35 rifampicin
rpoC 767035 c.3666G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.47 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.49 rifampicin
rpoC 767093 c.3724_3726delAGCinsTCG synonymous_variant 0.44 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.45 rifampicin
rpoC 767113 c.3744G>C synonymous_variant 0.44 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767152 c.3783T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767173 c.3804C>G synonymous_variant 0.32 rifampicin
rpoC 767180 p.Ala1271Thr missense_variant 0.38 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781766 c.207C>T synonymous_variant 0.5 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.53 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.66 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.47 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.45 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.61 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.61 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.62 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.56 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.46 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.46 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.67 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.49 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.63 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.67 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.69 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.68 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.56 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.68 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.58 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.56 streptomycin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303545 c.615A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303548 c.618G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471997 n.152T>C non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472027 n.182C>T non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472057 n.212C>A non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472062 n.217G>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472068 n.223T>C non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472069 n.224G>A non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472449 n.604C>A non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472463 n.618G>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472467 n.622G>T non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472495 n.650C>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>A non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472582 n.737G>A non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473673 n.16G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473677 n.20C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473679 n.22T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474153 n.496C>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474166 n.509G>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756A>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474415 n.759_781delCACACGCGCATACGCGCGTGTGA non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474450 n.793T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1474709 n.1052G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474710 n.1053T>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474716 n.1059_1060delAAinsGAG non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474740 n.1083G>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474747 n.1090C>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404_1408delCAAGGinsAAGA non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1475067 n.1410A>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475422 n.1765A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>A non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475481 n.1824C>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475761 n.2104_2108delCGCAAinsACTTCG non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476087 n.2430C>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476091 n.2434_2435insC non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.76 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.73 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.73 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.8 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867delCinsGA non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.81 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.78 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833254 c.-288G>C upstream_gene_variant 1.0 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.44 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.43 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.45 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.43 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.53 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.48 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.53 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.56 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.61 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.66 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.66 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.58 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.6 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.6 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.57 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.59 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.59 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.66 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.59 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.54 pyrazinamide
rpsA 1833838 c.297G>A synonymous_variant 0.6 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.64 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.64 pyrazinamide
rpsA 1833850 c.309C>G synonymous_variant 0.59 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.68 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.7 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.69 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.72 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.65 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.7 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.63 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.7 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.64 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.68 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.59 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.63 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.63 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.63 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.65 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.66 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.62 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.52 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834108 c.567C>A synonymous_variant 0.35 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834135 c.594G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834210 c.669C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
rpsA 1834306 c.765T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.44 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>T synonymous_variant 0.4 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.37 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.45 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.53 pyrazinamide Uncertain significance
rpsA 1834465 c.924T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834468 c.927A>C synonymous_variant 0.52 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.66 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834534 c.993C>G synonymous_variant 0.51 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1834543 c.1002C>G synonymous_variant 0.49 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834556 p.Ala339Thr missense_variant 0.52 pyrazinamide Uncertain significance
rpsA 1834573 c.1032G>A synonymous_variant 0.47 pyrazinamide
rpsA 1834574 p.Met345Leu missense_variant 0.45 pyrazinamide
rpsA 1834600 c.1059G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834627 c.1086C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.47 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834650 p.Thr370Ser missense_variant 0.45 pyrazinamide
rpsA 1834653 p.Glu371Ala missense_variant 0.42 pyrazinamide
rpsA 1834663 c.1122C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834667 c.1126_1128delGCGinsTC frameshift_variant&missense_variant 0.47 pyrazinamide Uncertain significance
rpsA 1834688 c.1147_1149delAGTinsTCG synonymous_variant 0.44 pyrazinamide
rpsA 1834699 p.Glu386Asp missense_variant 0.5 pyrazinamide
rpsA 1834712 p.Ile391Val missense_variant 0.47 pyrazinamide Uncertain significance
rpsA 1834732 c.1191T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.53 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.64 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.66 pyrazinamide
rpsA 1834759 c.1218A>G synonymous_variant 0.45 pyrazinamide
rpsA 1834761 p.Phe407Tyr missense_variant 0.41 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.45 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.44 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.45 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.47 pyrazinamide
rpsA 1834788 p.Ala416Gly missense_variant 0.42 pyrazinamide
rpsA 1834810 c.1269C>T synonymous_variant 0.36 pyrazinamide
rpsA 1834813 c.1272G>T synonymous_variant 0.36 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.31 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.39 isoniazid
Rv2477c 2782558 c.1485T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782582 c.1459_1461delAACinsGA frameshift_variant&missense_variant 0.38 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782586 p.Leu486Gln missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782591 c.1452T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782594 c.1449T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782603 c.1440G>A synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782606 c.1437T>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782612 c.1431T>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782621 c.1422T>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782624 c.1419G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782633 c.1410G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782636 c.1407G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782639 c.1404A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782651 c.1392T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
fbiD 3339117 c.-1C>A upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3626804 c.546A>G synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626825 c.-212T>G upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3626831 c.-218T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626857 c.-244T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626908 p.Asn148Asp missense_variant 0.23 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.23 bedaquiline
rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877665 c.843C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877734 c.774G>C synonymous_variant 0.38 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.4 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.34 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877794 c.714G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877800 c.708G>C synonymous_variant 0.19 rifampicin
rpoA 3877803 c.705G>A synonymous_variant 0.19 rifampicin
rpoA 3877821 c.687C>A synonymous_variant 0.18 rifampicin
rpoA 3877824 c.684G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877896 c.612G>A synonymous_variant 0.26 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.3 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.24 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.28 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878102 p.Val136Ile missense_variant 0.24 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.24 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.21 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.3 rifampicin
rpoA 3878124 c.384G>C synonymous_variant 0.2 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.2 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.28 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.21 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Asp missense_variant 0.29 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.21 rifampicin
rpoA 3878153 p.His119Asn missense_variant 0.21 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.21 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878217 c.289_291delCTAinsGC frameshift_variant&missense_variant 0.35 rifampicin
rpoA 3878244 p.Glu88Asp missense_variant 0.3 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.37 rifampicin
rpoA 3878251 c.256_257delTCinsAG synonymous_variant 0.39 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.39 rifampicin
rpoA 3878259 c.249G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878262 c.244_246delAGCinsGA frameshift_variant&missense_variant 0.39 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.52 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3879097 c.-590C>A upstream_gene_variant 0.35 rifampicin
rpoA 3879121 c.-614T>C upstream_gene_variant 0.39 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.44 rifampicin
rpoA 3879130 c.-623A>G upstream_gene_variant 0.39 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.47 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.35 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.38 rifampicin
rpoA 3879181 c.-676_-674delAAGinsCGT upstream_gene_variant 0.29 rifampicin
rpoA 3879202 c.-695T>A upstream_gene_variant 0.3 rifampicin
clpC1 4038740 c.1965G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038749 c.1956C>A synonymous_variant 0.69 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.69 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.69 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.76 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.83 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.88 pyrazinamide
clpC1 4038791 c.1914G>C synonymous_variant 0.79 pyrazinamide
clpC1 4038794 p.Ser637Thr missense_variant 0.79 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.9 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.89 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.88 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4038911 c.1794G>C synonymous_variant 0.73 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.5 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.53 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039010 c.1695G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039016 c.1689C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039031 c.1674T>A synonymous_variant 0.32 pyrazinamide
clpC1 4039040 c.1665C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039043 c.1662G>T synonymous_variant 0.44 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.32 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039499 c.1206G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.71 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.7 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.64 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Ser missense_variant 0.65 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039646 p.Glu353Asp missense_variant 0.46 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039652 c.1051_1053delACGinsTC frameshift_variant&missense_variant 0.43 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.55 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.53 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.59 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.6 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.56 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.58 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.7 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.52 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.5 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.49 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.51 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4039925 c.780C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.51 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.46 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040063 c.642G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040465 c.240T>C synonymous_variant 0.6 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
glpK 4138625 c.1131G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4248441 p.Thr643Ile missense_variant 1.0 ethambutol Uncertain significance
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
aftB 4269183 c.-347T>C upstream_gene_variant 0.29 ethambutol
ubiA 4269190 p.Ser215Thr missense_variant 0.29 ethambutol
ubiA 4269199 p.Ser212Asn missense_variant 0.29 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.29 ethambutol
ubiA 4269211 p.Lys208Arg missense_variant 0.28 ethambutol Uncertain significance
ubiA 4269220 p.Ala205Lys missense_variant 0.25 ethambutol
ubiA 4269222 c.612T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
aftB 4269234 c.-398A>G upstream_gene_variant 0.32 ethambutol
aftB 4269240 c.-404G>C upstream_gene_variant 0.32 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.32 ethambutol
ubiA 4269270 p.Val188Ala missense_variant 0.36 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R