TB-Profiler result

Run: ERR4799547
Summary

Run ID: ERR4799547

Sample name:

Date: 2024-04-15T06:53:49.539939

Number of reads: 755440

Percentage reads mapped: 28.97

Median coverage: 17.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.95
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.88
lineage2.2 East-Asian (Beijing) RD105;RD207 0.94
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.757_759delCGGinsGC Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1774_1776delCACinsTT Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1304704 c.1774_1776delCACinsTT frameshift_variant&missense_variant 0.46 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155353 c.757_759delCGGinsGC frameshift_variant&synonymous_variant 0.34 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 744 c.744C>T synonymous_variant 0.38 isoniazid
dnaA 747 c.747G>T synonymous_variant 0.39 isoniazid
dnaA 748 c.748_750delCTCinsTG frameshift_variant&missense_variant 0.39 isoniazid Uncertain significance
dnaA 763 p.Lys255Arg missense_variant 0.45 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.5 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.5 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.55 isoniazid Uncertain significance
dnaA 801 c.801G>T synonymous_variant 0.55 isoniazid
dnaA 804 c.804G>C synonymous_variant 0.55 isoniazid
dnaA 805 c.805T>C synonymous_variant 0.61 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.55 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.59 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.59 isoniazid Not assoc w R - Interim
dnaA 837 c.837A>G synonymous_variant 0.59 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.59 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.57 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.57 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.5 isoniazid
dnaA 894 c.894G>A synonymous_variant 0.5 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.5 isoniazid
dnaA 903 c.903C>G synonymous_variant 0.5 isoniazid Not assoc w R - Interim
dnaA 909 c.909A>C synonymous_variant 0.47 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.47 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.41 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 924 c.924C>G synonymous_variant 0.41 isoniazid
dnaA 928 p.Gln310Gly missense_variant 0.41 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.44 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.43 isoniazid
dnaA 948 c.948C>T synonymous_variant 0.45 isoniazid
dnaA 955 c.955_957delAGAinsCT frameshift_variant&missense_variant 0.41 isoniazid Uncertain significance
gyrA 6976 c.-326A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6994 c.-308C>T upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7010 p.Leu591Met missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7024 c.-278G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7030 c.-272C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.32 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7397 c.96G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7421 c.120G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7424 c.123G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7430 c.129G>A synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7439 c.138C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7451 c.150C>A synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7454 c.153G>A synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7466 c.165G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7505 c.204C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7715 c.414G>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 7727 c.426G>T synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.58 levofloxacin
moxifloxacin
gyrA 7745 c.444G>A synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7760 c.459C>T synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 7781 c.480G>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 7782 p.Gln161Met missense_variant 0.72 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7818 c.517C>T synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7868 p.Ile189Met missense_variant 0.55 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7886 c.585T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8930 c.1629C>T synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8945 c.1644G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Lys missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8993 c.1692C>T synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.47 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9026 c.1725G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9063 c.1762_1764delTCCinsGT frameshift_variant&missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>T synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9098 c.1797G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9113 c.1812C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
mshA 575734 c.387T>G synonymous_variant 0.35 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575744 p.Ala133Thr missense_variant 0.37 ethionamide
isoniazid Uncertain significance
mshA 575755 c.408G>A synonymous_variant 0.37 ethionamide
isoniazid
mshA 575761 c.414C>A synonymous_variant 0.37 ethionamide
isoniazid
mshA 575771 p.Val142Ile missense_variant 0.37 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575788 c.441C>T synonymous_variant 0.37 ethionamide
isoniazid
mshA 575792 p.Asp149Asn missense_variant 0.37 ethionamide
isoniazid
mshA 575795 c.448_450delATCinsCG frameshift_variant&missense_variant 0.37 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575800 c.453G>T synonymous_variant 0.37 ethionamide
isoniazid
mshA 575806 c.459G>C synonymous_variant 0.37 ethionamide
isoniazid
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.85 ethionamide Uncertain significance
nusG 734452 c.199_201delGAAinsCG frameshift_variant&missense_variant 0.48 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
nusG 734478 c.225C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
nusG 734497 c.244_246delGTGinsAC frameshift_variant&missense_variant 0.56 rifampicin
nusG 734511 c.258C>A synonymous_variant 0.58 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.6 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
nusG 734586 c.333G>C synonymous_variant 0.52 rifampicin
nusG 734595 p.Asp114Glu missense_variant 0.4 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.4 rifampicin
nusG 734600 p.Thr116Asn missense_variant 0.38 rifampicin Uncertain significance
nusG 734607 p.Asp118Glu missense_variant 0.38 rifampicin
rpoB 760154 c.348C>T synonymous_variant 0.33 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760220 c.414C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760274 p.Glu156Asp missense_variant 0.33 rifampicin Uncertain significance
rpoB 760298 c.492G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.27 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.24 rifampicin
rpoB 760357 p.Thr184Asn missense_variant 0.3 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.36 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.44 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.5 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.56 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.56 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>A synonymous_variant 0.58 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760436 c.630C>G synonymous_variant 0.58 rifampicin
rpoB 760457 c.651C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.59 rifampicin
rpoB 760502 c.696C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.6 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.59 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.5 rifampicin
rpoB 760567 c.761delCinsGGG frameshift_variant&missense_variant 0.5 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.53 rifampicin
rpoB 760588 p.Thr261Ile missense_variant 0.53 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.54 rifampicin
rpoB 760595 c.789C>A synonymous_variant 0.57 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.57 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760668 c.862_864delACGinsGC frameshift_variant&missense_variant 0.39 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760817 c.1011A>G synonymous_variant 0.41 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.39 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760858 p.Val351Ala missense_variant 0.57 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760886 p.Glu360Asp missense_variant 0.62 rifampicin Uncertain significance
rpoB 760887 p.Thr361Val missense_variant 0.62 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.7 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.7 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.68 rifampicin
rpoB 760988 c.1182C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.88 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.89 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAC frameshift_variant&missense_variant 0.68 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.69 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761347 p.Val514Ala missense_variant 0.5 rifampicin
rpoB 761351 p.Asp515Glu missense_variant 0.47 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.39 rifampicin
rpoB 761357 c.1551G>C synonymous_variant 0.39 rifampicin
rpoB 761362 p.Ser519Thr missense_variant 0.37 rifampicin
rpoB 761531 c.1725C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.72 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.75 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.75 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.79 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.8 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.78 rifampicin
rpoB 761690 c.1884G>T synonymous_variant 0.78 rifampicin
rpoB 761693 c.1887G>C synonymous_variant 0.77 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.69 rifampicin
rpoB 761723 c.1917A>G synonymous_variant 0.69 rifampicin
rpoB 761724 c.1918_1920delGAAinsAG frameshift_variant&missense_variant 0.69 rifampicin
rpoB 761728 p.Ser641Thr missense_variant 0.69 rifampicin
rpoB 761732 c.1926C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761741 c.1935G>A synonymous_variant 0.68 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.67 rifampicin
rpoB 761760 p.Ile652Val missense_variant 0.65 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.62 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.59 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.61 rifampicin
rpoB 761791 p.Arg662Gln missense_variant 0.61 rifampicin
rpoB 761794 p.Thr663Ser missense_variant 0.59 rifampicin
rpoB 761802 p.Met666Leu missense_variant 0.59 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.59 rifampicin
rpoB 761819 c.2013G>T synonymous_variant 0.52 rifampicin
rpoB 761881 p.Ala692Val missense_variant 0.41 rifampicin
rpoB 761891 c.2085G>T synonymous_variant 0.5 rifampicin
rpoB 761892 p.Ile696Leu missense_variant 0.5 rifampicin
rpoB 761906 c.2100C>T synonymous_variant 0.45 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.43 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.48 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.45 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.45 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.45 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.45 rifampicin
rpoB 761936 c.2130C>T synonymous_variant 0.44 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>A synonymous_variant 0.46 rifampicin
rpoB 761955 c.2149_2151delATCinsGT frameshift_variant&missense_variant 0.46 rifampicin
rpoB 761969 c.2163G>A synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.63 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.64 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.66 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.66 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.74 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.74 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.85 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.65 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.7 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762323 c.2517C>A synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.65 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.61 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.58 rifampicin
rpoB 762350 c.2544C>G synonymous_variant 0.58 rifampicin
rpoB 762353 c.2547C>T synonymous_variant 0.56 rifampicin
rpoB 762356 p.Glu850Asp missense_variant 0.56 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.55 rifampicin
rpoB 762368 p.Glu854Asp missense_variant 0.55 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.55 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.57 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.53 rifampicin
rpoC 762383 c.-987C>G upstream_gene_variant 0.54 rifampicin
rpoC 762395 c.-975G>T upstream_gene_variant 0.51 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.51 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.51 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762449 c.2643C>A synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.51 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.51 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 762533 c.-837T>C upstream_gene_variant 0.47 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.45 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.45 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.52 rifampicin
rpoC 762560 c.-810A>T upstream_gene_variant 0.43 rifampicin
rpoC 762563 c.-807G>T upstream_gene_variant 0.38 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.57 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 762959 c.-411G>T upstream_gene_variant 0.66 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.29 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763157 c.3351G>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763450 c.81G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.66 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.68 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>C synonymous_variant 0.68 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.68 rifampicin
rpoC 763711 c.342G>T synonymous_variant 0.68 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.74 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.72 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.72 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.66 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.62 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.36 rifampicin
rpoC 763836 p.Ala156Glu missense_variant 0.33 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.33 rifampicin
rpoC 763844 p.Arg159Lys missense_variant 0.3 rifampicin
rpoC 763857 p.Glu163Ala missense_variant 0.29 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.29 rifampicin
rpoC 763867 c.498C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763872 p.Gly168Ala missense_variant 0.27 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.24 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.24 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.25 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.24 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.24 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.43 rifampicin
rpoC 764386 c.1017C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.43 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.44 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.48 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.45 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.55 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>A synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.58 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.6 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>T synonymous_variant 0.5 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764810 p.Pro481Ala missense_variant 0.61 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.62 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.62 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764905 c.1536C>T synonymous_variant 0.59 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.57 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.57 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579_1581delTTGinsCC frameshift_variant&missense_variant 0.53 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1644delAGCinsTCG synonymous_variant 0.59 rifampicin
rpoC 765016 c.1647C>G synonymous_variant 0.62 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.5 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.5 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.57 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765100 c.1731G>C synonymous_variant 0.52 rifampicin
rpoC 765103 c.1734G>T synonymous_variant 0.55 rifampicin
rpoC 765121 c.1752G>T synonymous_variant 0.41 rifampicin
rpoC 765379 c.2010G>C synonymous_variant 0.48 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.48 rifampicin Uncertain significance
rpoC 765398 c.2029C>T synonymous_variant 0.52 rifampicin
rpoC 765403 c.2034G>C synonymous_variant 0.5 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.52 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765412 c.2043T>C synonymous_variant 0.56 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765449 c.2080_2082delGCCinsTG frameshift_variant&missense_variant 0.5 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.55 rifampicin
rpoC 765469 c.2100G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 0.62 rifampicin
rpoC 765480 p.Tyr704Phe missense_variant 0.63 rifampicin Uncertain significance
rpoC 765499 c.2130C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.36 rifampicin
rpoC 765533 p.Tyr722His missense_variant 0.36 rifampicin Uncertain significance
rpoC 765875 p.Val836Ile missense_variant 0.32 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.37 rifampicin
rpoC 765907 c.2538G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.39 rifampicin
rpoC 765947 c.2578_2580delTTGinsCC frameshift_variant&missense_variant 0.39 rifampicin
rpoC 765952 c.2583G>C synonymous_variant 0.38 rifampicin
rpoC 765955 c.2586C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593_2595delTTGinsCC frameshift_variant&missense_variant 0.39 rifampicin
rpoC 765973 c.2604C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.24 rifampicin
rpoC 766312 c.2943T>C synonymous_variant 0.38 rifampicin
rpoC 766522 c.3153C>A synonymous_variant 0.27 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.32 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.5 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.56 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.54 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.53 rifampicin
rpoC 766624 c.3255G>T synonymous_variant 0.55 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.53 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.53 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.47 rifampicin
rpoC 766660 c.3291G>T synonymous_variant 0.46 rifampicin
rpoC 766661 p.Val1098Pro missense_variant 0.46 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.46 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.46 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.46 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.44 rifampicin
rpoC 766693 c.3324C>A synonymous_variant 0.45 rifampicin
rpoC 766843 c.3474T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766867 c.3498C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766883 c.3514_3516delTCGinsGA frameshift_variant&missense_variant 0.55 rifampicin
rpoC 766891 c.3522G>A synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.56 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.56 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.58 rifampicin
rpoC 766909 c.3540G>C synonymous_variant 0.56 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.56 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.56 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766920 p.Ala1184Gly missense_variant 0.55 rifampicin
rpoC 766931 c.3562_3564delGCAinsTG frameshift_variant&stop_gained 0.57 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766960 c.3591C>T synonymous_variant 0.65 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 767071 c.3702C>G synonymous_variant 0.57 rifampicin
rpoC 767080 c.3711G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767100 p.Lys1244Arg missense_variant 0.54 rifampicin
rpoC 767104 c.3735C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Ser missense_variant 0.39 rifampicin Uncertain significance
rpoC 767191 c.3822C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 0.31 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.44 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.47 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.44 streptomycin
rpsL 781670 c.111G>C synonymous_variant 0.59 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.68 streptomycin
rpsL 781706 c.147T>G synonymous_variant 0.68 streptomycin
rpsL 781715 c.156T>G synonymous_variant 0.65 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.64 streptomycin
rpsL 781725 p.Lys56Arg missense_variant 0.64 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.64 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.67 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.67 streptomycin
rpsL 781737 p.Gln60Ala missense_variant 0.67 streptomycin
rpsL 781742 c.183C>A synonymous_variant 0.59 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.67 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.64 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.61 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.61 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.61 streptomycin Not assoc w R - Interim
rpsL 781769 c.210G>A synonymous_variant 0.64 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.52 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.48 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.5 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.48 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.41 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.43 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.43 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.41 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.4 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.41 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.35 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.34 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.32 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.34 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.26 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.25 streptomycin
rplC 800537 c.-272C>G upstream_gene_variant 0.25 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.25 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.35 linezolid
rplC 800639 c.-170C>T upstream_gene_variant 0.44 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.44 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.43 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.47 linezolid
rplC 800666 c.-143C>T upstream_gene_variant 0.37 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.34 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 0.35 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.4 linezolid
rplC 800703 c.-106_-104delTTGinsCC upstream_gene_variant 0.45 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.44 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.44 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.44 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.4 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.34 linezolid
rplC 800768 c.-41C>T upstream_gene_variant 0.31 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1304613 c.1683T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304649 c.1719C>T synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304660 p.Tyr577Phe missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304672 p.Val581Ala missense_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Glu missense_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304682 c.1752C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304684 p.Ala585Gly missense_variant 0.48 clofazimine Uncertain significance
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>T synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.44 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1461149 c.105T>G synonymous_variant 0.6 bedaquiline
atpE 1461161 c.117C>G synonymous_variant 0.62 bedaquiline
atpE 1461164 c.120C>T synonymous_variant 0.6 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.59 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.57 bedaquiline
atpE 1461179 c.135G>T synonymous_variant 0.59 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.59 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.59 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.58 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.57 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>T non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472050 n.205G>C non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472846 n.1001C>T non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473684 n.27G>A non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1473696 n.39_40delTCinsCTA non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1473699 n.43delG non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1473829 n.172G>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473950 n.293G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1474044 n.387C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474074 n.417C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474089 n.432C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1474100 n.443C>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474103 n.446A>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474106 n.449_450insCT non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474109 n.453_454delAT non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524_525insT non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474184 n.527C>A non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1474289 n.632C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756A>C non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474416 n.759_782delCACACGCGCATACGCGCGTGTGAAinsG non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1474708 n.1051_1052insAATAA non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474712 n.1055_1060delGTGTAAinsAG non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1474743 n.1086T>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1406delA non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476085 n.2428G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476114 n.2457T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.81 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.9 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.91 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.81 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673772 c.-430C>G upstream_gene_variant 0.46 ethionamide
isoniazid
inhA 1673778 c.-424C>G upstream_gene_variant 0.54 ethionamide
isoniazid
inhA 1673787 c.-415G>T upstream_gene_variant 0.54 ethionamide
isoniazid Uncertain significance
inhA 1673799 c.-403T>G upstream_gene_variant 0.54 ethionamide
isoniazid
inhA 1673802 c.-400A>G upstream_gene_variant 0.54 ethionamide
isoniazid
inhA 1673808 c.-394A>C upstream_gene_variant 0.55 ethionamide
isoniazid
fabG1 1673829 p.Asn130Lys missense_variant 0.6 ethionamide
isoniazid
fabG1 1673830 p.Lys131Arg missense_variant 0.58 ethionamide
isoniazid
inhA 1673838 c.-364T>C upstream_gene_variant 0.56 ethionamide
isoniazid
inhA 1673841 c.-361A>G upstream_gene_variant 0.56 ethionamide
isoniazid
inhA 1673847 c.-355A>C upstream_gene_variant 0.53 ethionamide
isoniazid
inhA 1673853 c.-349A>C upstream_gene_variant 0.55 ethionamide
isoniazid
inhA 1673856 c.-346T>C upstream_gene_variant 0.56 ethionamide
isoniazid
fabG1 1673870 p.Ser144Thr missense_variant 0.61 ethionamide
isoniazid
inhA 1673883 c.-319C>A upstream_gene_variant 0.61 ethionamide
isoniazid
inhA 1673886 c.-316C>T upstream_gene_variant 0.61 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.61 ethionamide
isoniazid
inhA 1673916 c.-286A>T upstream_gene_variant 0.61 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.59 ethionamide
isoniazid
inhA 1673925 c.-277C>G upstream_gene_variant 0.56 ethionamide
isoniazid
fabG1 1673926 p.Met163Leu missense_variant 0.56 ethionamide
isoniazid
inhA 1673931 c.-271C>G upstream_gene_variant 0.56 ethionamide
isoniazid
inhA 1673934 c.-268C>T upstream_gene_variant 0.61 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.6 ethionamide
isoniazid
inhA 1673961 c.-241A>G upstream_gene_variant 0.61 ethionamide
isoniazid
fabG1 1673962 p.Asn175Gly missense_variant 0.59 ethionamide
isoniazid
inhA 1673973 c.-229G>C upstream_gene_variant 0.59 ethionamide
isoniazid Uncertain significance
inhA 1673976 c.-226T>C upstream_gene_variant 0.59 ethionamide
isoniazid
inhA 1673982 c.-220G>C upstream_gene_variant 0.62 ethionamide
isoniazid
inhA 1673985 c.-217C>A upstream_gene_variant 0.68 ethionamide
isoniazid
inhA 1673991 c.-211C>T upstream_gene_variant 0.68 ethionamide
isoniazid
fabG1 1673993 p.Tyr185Phe missense_variant 0.68 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.72 ethionamide
isoniazid
inhA 1674012 c.-190C>T upstream_gene_variant 0.62 ethionamide
isoniazid
fabG1 1674016 p.Ala193Ser missense_variant 0.67 ethionamide
isoniazid
inhA 1674021 c.-181G>C upstream_gene_variant 0.69 ethionamide
isoniazid
inhA 1674033 c.-169T>C upstream_gene_variant 0.55 ethionamide
isoniazid
fabG1 1674037 p.Gln200Glu missense_variant 0.55 ethionamide
isoniazid
rpsA 1833580 c.39C>T synonymous_variant 0.35 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.38 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.39 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.41 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.52 pyrazinamide
rpsA 1833616 c.75A>T synonymous_variant 0.59 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.6 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.6 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.65 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.59 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.59 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.58 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.61 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.6 pyrazinamide
rpsA 1833697 c.156C>T synonymous_variant 0.59 pyrazinamide
rpsA 1833700 c.159C>T synonymous_variant 0.63 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.65 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.64 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.66 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.65 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.65 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.69 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.68 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.68 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.71 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.7 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.69 pyrazinamide
rpsA 1833823 c.282G>A synonymous_variant 0.66 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.7 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.7 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.7 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.73 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.73 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.69 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.68 pyrazinamide
rpsA 1833877 c.336C>G synonymous_variant 0.68 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.67 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.63 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.76 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.68 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.68 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.69 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.67 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.65 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.65 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.61 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.59 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.61 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.59 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834073 p.Lys178Arg missense_variant 0.52 pyrazinamide
rpsA 1834087 c.546C>T synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
rpsA 1834096 c.555G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
rpsA 1834213 c.672G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834228 c.687C>A synonymous_variant 0.36 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.38 pyrazinamide
rpsA 1834234 c.693G>T synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834240 c.699T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.4 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.39 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.5 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.52 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.53 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.6 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.62 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.57 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.6 pyrazinamide
rpsA 1834405 c.864C>G synonymous_variant 0.62 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.61 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.59 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.64 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.66 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.71 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834520 c.979_981delGCCinsTG frameshift_variant&missense_variant 0.59 pyrazinamide Uncertain significance
rpsA 1834528 c.987T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.64 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.65 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.65 pyrazinamide
tsnR 1853361 c.-245_-243delTTGinsCC upstream_gene_variant 0.32 linezolid
tsnR 1853372 c.-234A>G upstream_gene_variant 0.36 linezolid
tsnR 1853375 c.-231G>T upstream_gene_variant 0.38 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155293 c.819T>C synonymous_variant 0.35 isoniazid
katG 2155299 c.813T>C synonymous_variant 0.36 isoniazid
katG 2155311 c.801C>G synonymous_variant 0.37 isoniazid
katG 2155320 c.792G>A synonymous_variant 0.37 isoniazid
katG 2155326 c.786A>C synonymous_variant 0.37 isoniazid
katG 2155332 p.Val260Glu missense_variant 0.35 isoniazid
katG 2155344 c.768C>A synonymous_variant 0.35 isoniazid
katG 2155350 c.762C>G synonymous_variant 0.37 isoniazid
katG 2155356 c.756T>C synonymous_variant 0.36 isoniazid
katG 2155359 c.753G>C synonymous_variant 0.36 isoniazid
katG 2155376 p.Val246Ile missense_variant 0.41 isoniazid
katG 2155380 c.732G>C synonymous_variant 0.43 isoniazid
katG 2155388 p.Met242Leu missense_variant 0.41 isoniazid
katG 2155389 c.723C>G synonymous_variant 0.41 isoniazid Not assoc w R
katG 2155410 c.702G>C synonymous_variant 0.46 isoniazid Not assoc w R - Interim
katG 2155413 c.699G>A synonymous_variant 0.42 isoniazid
katG 2155416 c.696G>C synonymous_variant 0.38 isoniazid
katG 2155419 c.693C>T synonymous_variant 0.38 isoniazid
katG 2155422 c.690G>C synonymous_variant 0.38 isoniazid Not assoc w R - Interim
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>C upstream_gene_variant 0.29 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.3 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.4 isoniazid
kasA 2518768 c.654C>A synonymous_variant 0.38 isoniazid
kasA 2518771 c.657C>A synonymous_variant 0.38 isoniazid
kasA 2518774 c.660C>T synonymous_variant 0.4 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.4 isoniazid
kasA 2518783 c.669T>G synonymous_variant 0.4 isoniazid
kasA 2518787 p.Arg225Lys missense_variant 0.4 isoniazid
kasA 2518792 c.678C>T synonymous_variant 0.38 isoniazid
kasA 2518795 c.681C>T synonymous_variant 0.35 isoniazid
kasA 2518798 c.684G>T synonymous_variant 0.35 isoniazid
kasA 2518822 c.708C>A synonymous_variant 0.33 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.33 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.33 isoniazid
kasA 2518846 c.732G>C synonymous_variant 0.3 isoniazid
kasA 2518853 p.Leu247Val missense_variant 0.37 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.33 isoniazid
Rv2752c 3067039 c.-848T>C upstream_gene_variant 0.89 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyA 3073947 c.525G>C synonymous_variant 0.53 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.54 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3073965 c.507C>T synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3073971 c.501C>T synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3073980 c.492C>T synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073983 c.489C>G synonymous_variant 0.38 para-aminosalicylic_acid
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625765 c.849C>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626704 c.-91C>T upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626717 c.-104C>T upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3626735 c.-122C>G upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrA 3626756 c.594C>G synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626762 c.588G>C synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626776 c.-163A>C upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.57 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>C upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626825 c.525T>A synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626843 c.-230G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627059 c.-446G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627073 c.277C>T synonymous_variant 0.24 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627080 c.270T>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
fbiA 3640243 c.-300T>C upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
rpoA 3877560 c.948C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsAC frameshift_variant&missense_variant 0.48 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.56 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877665 c.843C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.53 rifampicin
rpoA 3877680 c.828G>T synonymous_variant 0.57 rifampicin
rpoA 3877685 c.823C>T synonymous_variant 0.56 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.47 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.46 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.45 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.47 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.48 rifampicin
rpoA 3877758 c.750G>C synonymous_variant 0.47 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.44 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.44 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877827 c.681C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>G synonymous_variant 0.44 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877860 c.648C>T synonymous_variant 0.49 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>T synonymous_variant 0.55 rifampicin
rpoA 3877887 c.621G>A synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.46 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.46 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.37 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.36 rifampicin
rpoA 3877977 p.Lys177Asn missense_variant 0.39 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.45 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.41 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.41 rifampicin
rpoA 3878028 c.480G>T synonymous_variant 0.41 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.41 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.41 rifampicin
rpoA 3878037 c.471C>T synonymous_variant 0.43 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.45 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.48 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.5 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.48 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.52 rifampicin
rpoA 3878102 p.Val136Ile missense_variant 0.61 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.59 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.61 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.54 rifampicin Uncertain significance
rpoA 3878145 c.363C>T synonymous_variant 0.54 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.62 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.64 rifampicin
rpoA 3878205 c.303T>A synonymous_variant 0.65 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3878244 c.264G>A synonymous_variant 0.61 rifampicin
rpoA 3878259 c.249G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.58 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.46 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878400 c.108T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878403 c.105C>T synonymous_variant 0.32 rifampicin
ddn 3986621 c.-223G>C upstream_gene_variant 0.35 delamanid
pretomanid
ddn 3986622 c.-222C>T upstream_gene_variant 0.35 delamanid
pretomanid
clpC1 4038749 c.1956C>T synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>C synonymous_variant 0.43 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.41 pyrazinamide
clpC1 4038770 c.1935C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.41 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.45 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038815 c.1890G>A synonymous_variant 0.43 pyrazinamide
clpC1 4038838 c.1867C>T synonymous_variant 0.4 pyrazinamide
clpC1 4038842 c.1863G>T synonymous_variant 0.4 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.42 pyrazinamide
clpC1 4038860 c.1845G>T synonymous_variant 0.54 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>G synonymous_variant 0.5 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.5 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.5 pyrazinamide
clpC1 4038914 c.1791G>T synonymous_variant 0.5 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.5 pyrazinamide
clpC1 4038923 c.1782A>T synonymous_variant 0.5 pyrazinamide
clpC1 4038928 c.1777C>A synonymous_variant 0.5 pyrazinamide
clpC1 4038929 c.1776G>A synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4038932 c.1773G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.52 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.55 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038977 c.1728G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.64 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.66 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.55 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.54 pyrazinamide
clpC1 4039077 p.Lys543Arg missense_variant 0.51 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.55 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.55 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.55 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.63 pyrazinamide
clpC1 4039124 c.1581C>A synonymous_variant 0.67 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.66 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.65 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.69 pyrazinamide
clpC1 4039178 c.1527G>T synonymous_variant 0.69 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.71 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.71 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.68 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
clpC1 4039265 c.1440C>T synonymous_variant 0.71 pyrazinamide
clpC1 4039271 c.1434G>A synonymous_variant 0.71 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.74 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>T synonymous_variant 0.74 pyrazinamide
clpC1 4039286 c.1419T>G synonymous_variant 0.73 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.74 pyrazinamide
clpC1 4039316 p.Glu463Asp missense_variant 0.7 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
clpC1 4039328 c.1377A>C synonymous_variant 0.7 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.62 pyrazinamide
clpC1 4039346 p.Arg453Ser missense_variant 0.64 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4039357 c.1348C>T synonymous_variant 0.64 pyrazinamide
clpC1 4039360 p.Ser449Arg missense_variant 0.64 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.64 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.68 pyrazinamide
clpC1 4039391 c.1314T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.66 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.66 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.64 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.52 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4039487 c.1218G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4039508 c.1197G>A synonymous_variant 0.56 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.55 pyrazinamide
clpC1 4039528 c.1177C>A synonymous_variant 0.61 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.62 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.64 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.64 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.64 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.62 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.68 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.72 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.73 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.73 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.72 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.72 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.72 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.63 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.62 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.63 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.59 pyrazinamide
clpC1 4039733 c.972G>T synonymous_variant 0.56 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.5 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.49 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.52 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.5 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.49 pyrazinamide
clpC1 4039913 c.792C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039925 c.780C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.49 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.61 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.63 pyrazinamide
clpC1 4040000 c.705C>T synonymous_variant 0.64 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.62 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.63 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.61 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.67 pyrazinamide
clpC1 4040087 c.618G>T synonymous_variant 0.69 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.68 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4040141 c.564C>T synonymous_variant 0.5 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.43 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.57 pyrazinamide
clpC1 4040168 c.537G>T synonymous_variant 0.5 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.53 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040345 c.360C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.36 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.59 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.57 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.59 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.57 pyrazinamide
clpC1 4040459 c.246C>G synonymous_variant 0.52 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.48 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4040525 c.180C>T synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.56 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4040540 c.165G>C synonymous_variant 0.57 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.51 pyrazinamide
clpC1 4040558 c.147G>T synonymous_variant 0.48 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.47 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040579 c.126A>G synonymous_variant 0.44 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.44 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.44 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.42 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.42 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.42 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.44 pyrazinamide
clpC1 4040642 c.61_63delAGGinsCC frameshift_variant&missense_variant 0.28 pyrazinamide
embC 4240756 c.894G>C synonymous_variant 0.46 ethambutol
embC 4240768 c.906G>C synonymous_variant 0.56 ethambutol
embC 4240771 c.909G>C synonymous_variant 0.58 ethambutol
embC 4240772 p.Ser304Ala missense_variant 0.58 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.59 ethambutol
embC 4240781 p.Ala307Ser missense_variant 0.58 ethambutol Uncertain significance
embC 4240789 c.927T>C synonymous_variant 0.55 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.56 ethambutol
embC 4240826 p.Ala322Ser missense_variant 0.54 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.51 ethambutol
embC 4240843 c.981C>T synonymous_variant 0.5 ethambutol
embC 4240856 c.994_996delGCGinsAC frameshift_variant&missense_variant 0.44 ethambutol
embC 4240859 c.997_999delCTGinsAC frameshift_variant&missense_variant 0.47 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.47 ethambutol
embC 4240885 c.1023T>C synonymous_variant 0.37 ethambutol
embC 4240886 p.Ile342Val missense_variant 0.36 ethambutol
embC 4240897 c.1035C>A synonymous_variant 0.25 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.93 ethambutol Not assoc w R
embA 4243958 c.726G>A synonymous_variant 0.57 ethambutol Not assoc w R - Interim
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R