TB-Profiler result

Run: ERR4821053
Summary

Run ID: ERR4821053

Sample name:

Date: 2024-04-16T09:58:11.423097

Number of reads: 2696130

Percentage reads mapped: 72.46

Median coverage: 54.0

Strain: lineage3

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.93
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin gid c.102delG Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1948_1950delCGCinsAG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.17 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.25 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.3 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.26 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304878 c.1948_1950delCGCinsAG frameshift_variant&missense_variant 0.23 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.3 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247448 p.His312Arg missense_variant 0.21 ethambutol Mutation from literature
gid 4408100 c.102delG frameshift_variant 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 187 c.187T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 540 c.540C>G synonymous_variant 0.18 isoniazid
dnaA 543 c.543C>G synonymous_variant 0.25 isoniazid
dnaA 549 c.549C>T synonymous_variant 0.26 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.32 isoniazid
dnaA 576 c.576G>C synonymous_variant 0.32 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 591 c.591C>G synonymous_variant 0.31 isoniazid
dnaA 600 c.600T>C synonymous_variant 0.31 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.3 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.33 isoniazid
dnaA 636 c.636C>G synonymous_variant 0.24 isoniazid
dnaA 645 c.645A>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 786 c.786C>T synonymous_variant 0.16 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.18 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.18 isoniazid
gyrB 5791 c.552A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 5806 c.567C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 5809 c.570C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 5815 c.576C>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 5824 c.585A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 5827 c.588G>A synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrB 5848 c.609G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrB 5863 c.624G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 5873 c.634A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 5882 c.643_645delCAAinsAC frameshift_variant&missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin
gyrB 5887 p.Asp216Glu missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6148 c.909C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6169 c.930C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6862 c.1623C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 7216 c.1977G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7225 c.-77T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7727 c.426G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7862 c.561C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7923 p.His208Tyr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8081 c.780A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8084 c.783G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8099 c.798T>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8253 p.Ile318Leu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8438 c.1137C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8535 p.Glu412Gln missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8765 p.Asp488Glu missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8779 p.Asp493Ala missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8796 c.1495_1497delATCinsGG frameshift_variant&missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8951 c.1650G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9204 p.Ser635Thr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9281 c.1980C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9383 c.2082T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9666 p.Arg789Gly missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9674 c.2373T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
fgd1 490803 c.21T>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490833 c.51G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490842 c.60C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491137 p.Glu119Gln missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.3 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.31 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491331 c.549G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491502 c.720G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491532 c.750G>T synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491542 c.760T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491583 c.801G>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 574625 c.-723C>G upstream_gene_variant 0.16 ethionamide
isoniazid
mshA 575623 c.276C>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575629 c.282A>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.2 ethionamide
isoniazid Not assoc w R - Interim
mshA 575649 p.Val101Glu missense_variant 0.15 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.18 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.22 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.19 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.16 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.22 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.22 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575767 c.420G>A synonymous_variant 0.29 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.27 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575827 c.480G>A synonymous_variant 0.27 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.18 ethionamide
isoniazid
ccsA 619591 c.-300G>C upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>G upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619648 c.-243C>G upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>C upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619655 c.-236A>G upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619669 c.-222G>C upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>C upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.26 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.21 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620461 p.Val191Ile missense_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620598 c.708C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>T synonymous_variant 0.17 capreomycin
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620607 c.717T>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
Rv0565c 656526 p.Glu315Asp missense_variant 0.19 ethionamide
Rv0565c 656535 c.936C>G synonymous_variant 0.2 ethionamide
Rv0565c 656539 p.Ser311Ala missense_variant 0.2 ethionamide
Rv0565c 656568 c.903G>C synonymous_variant 0.25 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657219 p.Ala84Val missense_variant 0.18 ethionamide
Rv0565c 657222 c.249C>G synonymous_variant 0.18 ethionamide
Rv0565c 657242 p.Glu77Lys missense_variant 0.15 ethionamide
hadA 731747 c.-183T>C upstream_gene_variant 0.21 isoniazid
hadA 731753 c.-177A>G upstream_gene_variant 0.2 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.18 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.17 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.18 isoniazid
hadA 732272 p.Ala115Ser missense_variant 0.16 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.17 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.2 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.23 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.24 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.24 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.31 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.29 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.27 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.24 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.24 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.18 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.17 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.3 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.28 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.29 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.34 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.35 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.33 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.33 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.29 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.29 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
nusG 734595 c.342C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734596 c.343T>C synonymous_variant 0.17 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.19 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.24 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.2 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.2 rifampicin
nusG 734661 c.408A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734664 c.411T>G synonymous_variant 0.17 rifampicin
nusG 734673 c.420A>G synonymous_variant 0.18 rifampicin
nusG 734679 c.426C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734680 c.427_429delGCCinsTG frameshift_variant&missense_variant 0.19 rifampicin
nusG 734754 c.501G>C synonymous_variant 0.32 rifampicin
nusG 734757 c.504T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734778 c.525G>C synonymous_variant 0.36 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.37 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.34 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.34 rifampicin Uncertain significance
nusG 734820 c.567A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.36 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
nusG 734832 c.579C>G synonymous_variant 0.33 rifampicin
nusG 734841 c.588G>A synonymous_variant 0.36 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.33 rifampicin
nusG 734853 c.600A>C synonymous_variant 0.23 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.25 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.26 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.2 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.2 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.2 rifampicin
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760130 p.Asp108Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.24 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.27 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.34 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.38 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.38 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.4 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.37 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.32 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.23 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.36 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.33 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760555 p.Glu250Ala missense_variant 0.24 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.18 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.24 rifampicin
rpoB 760602 p.Glu266Gln missense_variant 0.29 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.38 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.23 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.21 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.19 rifampicin
rpoB 760763 c.957C>T synonymous_variant 0.15 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.27 rifampicin
rpoB 760869 p.Val355Ile missense_variant 0.3 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.31 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.36 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.36 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.45 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.27 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.26 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.33 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.36 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.33 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.37 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.33 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761492 c.1686G>C synonymous_variant 0.17 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.28 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.34 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.23 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.23 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.21 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.2 rifampicin
rpoB 761723 c.1917_1919delAGAinsG frameshift_variant&synonymous_variant 0.24 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.25 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.28 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.29 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.29 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.23 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.25 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.24 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.27 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.27 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.3 rifampicin
rpoB 761847 p.Cys681Ser missense_variant 0.3 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.29 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.3 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>G synonymous_variant 0.31 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.28 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.31 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.2 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.2 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.21 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.21 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.21 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.27 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.3 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.28 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762027 c.2221_2223delCTCinsTG frameshift_variant&missense_variant 0.23 rifampicin
rpoB 762032 c.2226C>G synonymous_variant 0.21 rifampicin
rpoB 762035 c.2229G>C synonymous_variant 0.21 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 0.34 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.35 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.35 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.3 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.24 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.26 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.29 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.34 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.36 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.34 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.35 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.26 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.22 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.21 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.28 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 0.75 rifampicin Not assoc w R
rpoC 762443 c.-927G>T upstream_gene_variant 0.2 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.34 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.75 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.31 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.31 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.26 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.24 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.29 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.3 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.37 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.27 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.28 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.31 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.34 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.35 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.36 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.38 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.34 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.34 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.32 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.34 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.33 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.28 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.27 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.24 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.23 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.25 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.27 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.28 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.23 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.22 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.21 rifampicin
rpoC 763919 c.550C>T synonymous_variant 0.29 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.33 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.34 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.29 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.34 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.23 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.2 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.19 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.23 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764116 c.747C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.22 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.25 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.21 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.2 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.28 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.27 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.27 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.25 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.22 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.21 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.22 rifampicin
rpoC 764398 c.1029G>C synonymous_variant 0.24 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.21 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.21 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.2 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.27 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.28 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTG frameshift_variant&missense_variant 0.18 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.2 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.32 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.25 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.25 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.31 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.36 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.36 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.21 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765287 c.1918C>T synonymous_variant 0.26 rifampicin
rpoC 765292 c.1923G>T synonymous_variant 0.26 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.27 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.29 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.34 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.35 rifampicin Uncertain significance
rpoC 765349 c.1980T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.33 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.29 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.24 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.27 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.32 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.32 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765535 c.2166C>T synonymous_variant 0.25 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.23 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.22 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.22 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.29 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.28 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.37 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.32 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.25 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.22 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.17 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.19 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.19 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.29 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.27 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.23 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.26 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.38 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.49 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.46 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.45 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.42 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.41 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.38 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.3 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.18 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766327 c.2958C>G synonymous_variant 0.17 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.21 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.2 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.2 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.21 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.26 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.31 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.25 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.24 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.21 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.21 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.19 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.2 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.25 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.22 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.22 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.17 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.22 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.22 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.22 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.25 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.27 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.26 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.28 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.26 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.27 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.2 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.2 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.19 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.21 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.22 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.19 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.27 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.28 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.18 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776647 p.Val612Ile missense_variant 0.17 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776654 c.1827A>T synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 776663 c.1816_1818delACCinsGG frameshift_variant&missense_variant 0.26 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776678 c.1803G>C synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 776693 c.1788C>G synonymous_variant 0.21 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.18 streptomycin
rpsL 781608 c.49_51delAGTinsGC frameshift_variant&missense_variant 0.31 streptomycin Uncertain significance
rpsL 781631 c.72G>C synonymous_variant 0.38 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.43 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.48 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.45 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.42 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.38 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.38 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.24 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.27 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.26 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.2 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.24 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.26 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.32 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.36 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.37 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.44 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.45 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.48 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.49 streptomycin Uncertain significance
rplC 800648 c.-161A>C upstream_gene_variant 0.18 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.18 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.21 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.24 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.25 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.24 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.25 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.25 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.32 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.28 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.29 linezolid
rplC 800814 c.6A>G synonymous_variant 0.31 linezolid
rplC 800817 c.9A>T synonymous_variant 0.31 linezolid
rplC 800844 c.36T>C synonymous_variant 0.29 linezolid
rplC 800865 c.57A>G synonymous_variant 0.28 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.28 linezolid
rplC 800874 c.66A>G synonymous_variant 0.25 linezolid
rplC 800877 c.69A>C synonymous_variant 0.26 linezolid
rplC 800880 c.72A>G synonymous_variant 0.24 linezolid
rplC 800889 c.81C>G synonymous_variant 0.27 linezolid
rplC 800907 c.99C>G synonymous_variant 0.23 linezolid
rplC 800916 c.108A>G synonymous_variant 0.2 linezolid
rplC 800982 c.174C>T synonymous_variant 0.17 linezolid
rplC 800985 c.177A>G synonymous_variant 0.18 linezolid
rplC 800994 c.186C>G synonymous_variant 0.17 linezolid
rplC 801004 p.Leu66Val missense_variant 0.17 linezolid
rplC 801171 c.363A>G synonymous_variant 0.18 linezolid
rplC 801174 c.366T>C synonymous_variant 0.18 linezolid
rplC 801222 c.414T>C synonymous_variant 0.23 linezolid
rplC 801228 c.420T>C synonymous_variant 0.24 linezolid
rplC 801246 c.438C>G synonymous_variant 0.25 linezolid
rplC 801249 c.441T>G synonymous_variant 0.26 linezolid
rplC 801255 c.447C>T synonymous_variant 0.27 linezolid
rplC 801267 c.459A>C synonymous_variant 0.2 linezolid
rplC 801270 c.462T>C synonymous_variant 0.19 linezolid
rplC 801276 c.468G>C synonymous_variant 0.18 linezolid
rplC 801279 c.471G>C synonymous_variant 0.18 linezolid
rplC 801282 c.474G>C synonymous_variant 0.18 linezolid
rplC 801301 c.493C>A synonymous_variant 0.17 linezolid
rplC 801357 c.549T>C synonymous_variant 0.16 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.17 linezolid
rplC 801396 c.588T>C synonymous_variant 0.19 linezolid
rplC 801402 c.594T>C synonymous_variant 0.19 linezolid
rplC 801405 c.597T>C synonymous_variant 0.19 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303470 c.540T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303476 c.546G>C synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303480 p.Gln184Glu missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303560 c.630G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303660 p.Val244Thr missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303701 c.771C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303716 c.786C>T synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304080 p.Ala384Ser missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304520 c.1590A>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304523 c.1593G>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304727 c.1797A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.43 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.67 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304872 c.1942_1944delAGCinsTCG synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304877 c.1947T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304961 c.2031C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305311 p.Arg794Gln missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305381 c.2451G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305393 c.2463T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid
sigE 1364679 c.267T>C synonymous_variant 0.2 pyrazinamide
sigE 1364691 c.279T>C synonymous_variant 0.19 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.22 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.21 pyrazinamide
sigE 1364727 c.315C>T synonymous_variant 0.22 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.21 pyrazinamide
sigE 1364748 c.336G>C synonymous_variant 0.19 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.16 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.19 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.24 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.26 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.33 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.37 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.34 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.34 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.34 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.36 pyrazinamide
sigE 1364866 c.454_456delGCTinsTG frameshift_variant&missense_variant 0.34 pyrazinamide Uncertain significance
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.3 pyrazinamide Uncertain significance
sigE 1364904 p.Asp164Glu missense_variant 0.28 pyrazinamide
embR 1416261 c.1087C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
atpE 1461149 c.105T>G synonymous_variant 0.18 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.18 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.19 bedaquiline Uncertain significance
atpE 1461185 c.141G>C synonymous_variant 0.19 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.19 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.18 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.17 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
inhA 1673547 c.-655T>C upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.31 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>G upstream_gene_variant 0.31 ethionamide
isoniazid
inhA 1673595 c.-607A>C upstream_gene_variant 0.32 ethionamide
isoniazid
fabG1 1673596 c.157_159delAAGinsGC frameshift_variant&missense_variant 0.32 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.34 ethionamide
isoniazid
inhA 1673610 c.-592C>T upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1673616 c.-586A>G upstream_gene_variant 0.35 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.34 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.28 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1673658 c.-544G>A upstream_gene_variant 0.17 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.16 ethionamide
isoniazid
inhA 1673679 c.-523T>G upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1674315 c.114C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674321 c.120G>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674342 c.141T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674368 p.Ala56Glu missense_variant 0.15 ethionamide
isoniazid
inhA 1674379 c.178C>T synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674382 p.Leu61Ile missense_variant 0.15 ethionamide
isoniazid
inhA 1674399 c.198A>G synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.28 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.3 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.41 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.33 ethionamide
isoniazid
rpsA 1833541 c.-1T>C upstream_gene_variant 0.18 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.22 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.21 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.27 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.34 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.38 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.42 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.41 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.43 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.39 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.31 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.49 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.44 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.33 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.33 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834594 c.1053C>T synonymous_variant 0.39 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.27 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.24 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.33 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.33 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.23 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.19 linezolid
tsnR 1853370 c.-236G>T upstream_gene_variant 0.15 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064912 c.-184A>G upstream_gene_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064936 c.-208C>A upstream_gene_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064945 c.-217G>A upstream_gene_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064963 c.-235G>C upstream_gene_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101960 c.1083A>G synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2101978 c.1065C>T synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2101988 p.Ala352Gly missense_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102009 p.Ser345Asn missense_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102026 c.1017G>C synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102050 c.993T>C synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102218 c.825C>G synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102233 c.810G>A synonymous_variant 0.2 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102242 c.801G>A synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102305 c.738T>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102317 c.726A>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155029 c.1083C>G synonymous_variant 0.2 isoniazid
katG 2155032 c.1080T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
katG 2155054 p.Tyr353Phe missense_variant 0.23 isoniazid
katG 2155056 c.1056A>G synonymous_variant 0.23 isoniazid
katG 2155062 c.1050T>C synonymous_variant 0.22 isoniazid
katG 2155065 c.1047C>G synonymous_variant 0.22 isoniazid
katG 2155068 c.1044T>C synonymous_variant 0.22 isoniazid
katG 2155071 c.1041T>C synonymous_variant 0.22 isoniazid
katG 2155080 c.1032G>C synonymous_variant 0.2 isoniazid
katG 2155632 c.480A>C synonymous_variant 0.22 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.24 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.26 isoniazid Uncertain significance
katG 2155677 c.435C>G synonymous_variant 0.25 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.26 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.24 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.24 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.25 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.23 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.23 isoniazid
katG 2155741 p.Gly124Asp missense_variant 0.14 isoniazid Uncertain significance
katG 2155747 p.Ala122Gly missense_variant 0.16 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
pncA 2290006 c.-765T>C upstream_gene_variant 0.19 pyrazinamide
pncA 2290009 c.-768A>G upstream_gene_variant 0.18 pyrazinamide
pncA 2290030 c.-791_-789delAATinsCC upstream_gene_variant 0.18 pyrazinamide
pncA 2290033 c.-792C>G upstream_gene_variant 0.17 pyrazinamide
pncA 2290038 c.-797G>T upstream_gene_variant 0.17 pyrazinamide
pncA 2290042 c.-801T>C upstream_gene_variant 0.17 pyrazinamide
kasA 2517947 c.-168C>T upstream_gene_variant 0.4 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.38 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.33 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.33 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.16 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.21 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.24 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.25 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.22 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.21 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.2 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.19 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.23 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.23 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.22 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.25 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.29 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.3 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.33 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.29 isoniazid
kasA 2518690 c.576C>T synonymous_variant 0.29 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.32 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.35 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.29 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.3 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.32 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.31 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.3 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.22 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.29 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.3 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.25 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.25 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.25 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.28 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.27 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.19 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.18 isoniazid
kasA 2519125 c.1011C>T synonymous_variant 0.17 isoniazid
kasA 2519137 c.1023T>C synonymous_variant 0.23 isoniazid
kasA 2519146 c.1032C>A synonymous_variant 0.22 isoniazid
kasA 2519167 c.1053T>C synonymous_variant 0.19 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.2 isoniazid
kasA 2519176 c.1062G>A synonymous_variant 0.16 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
ahpC 2726546 c.354C>G synonymous_variant 0.18 isoniazid
ahpC 2726551 p.Gln120Leu missense_variant 0.18 isoniazid
ahpC 2726556 c.364_366delGCAinsAC frameshift_variant&missense_variant 0.17 isoniazid Uncertain significance
ahpC 2726564 c.372C>T synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ahpC 2726579 c.387T>C synonymous_variant 0.26 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.25 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.25 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.31 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.3 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.34 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.35 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.34 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.33 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.3 isoniazid Not assoc w R - Interim
ahpC 2726681 c.489A>G synonymous_variant 0.38 isoniazid
ahpC 2726687 c.495C>G synonymous_variant 0.38 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.29 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.28 isoniazid
ahpC 2726717 c.525A>G synonymous_variant 0.31 isoniazid
folC 2747040 p.Ile187Val missense_variant 0.16 para-aminosalicylic_acid
folC 2747065 c.534C>G synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747281 c.318A>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.18 para-aminosalicylic_acid
folC 2747290 c.309A>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.2 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.18 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.18 para-aminosalicylic_acid
Rv2477c 2782447 c.1596C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782450 c.1593C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 c.1590C>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782498 c.1545C>T synonymous_variant 0.69 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
Rv2477c 2782510 c.1533G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.4 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.53 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.53 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783243 p.Thr267Ser missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783373 p.Glu224Gln missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783416 c.625_627delATCinsGG frameshift_variant&missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783422 c.621T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.616_618delCCCinsGG frameshift_variant&missense_variant 0.28 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783432 p.Ser204Ala missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783434 c.609C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783578 p.Glu155Asp missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.45 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784301 c.-259T>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784306 c.-264G>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784311 c.-269T>G upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784315 c.-273G>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784321 c.-279A>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784324 c.-282G>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784327 c.-285G>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784330 c.-288G>A upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784357 c.-316_-315delTTinsAC upstream_gene_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784366 c.-324G>C upstream_gene_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784375 c.-333T>C upstream_gene_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784381 c.-339T>C upstream_gene_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784390 c.-348G>C upstream_gene_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784428 c.-386T>C upstream_gene_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784455 c.-413A>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3064958 p.Ser412Arg missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064962 c.1230C>A synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064973 p.Ala407Ser missense_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064974 c.1218T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064980 c.1212C>A synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064995 c.1197C>G synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064998 c.1194A>G synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065018 p.Asn392His missense_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065028 c.1164G>C synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065031 c.1161G>C synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065040 c.1152C>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065901 c.291A>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065916 p.Phe92Tyr missense_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065919 c.273G>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065925 p.Ala89Gly missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065928 c.264G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065947 p.Gly82Ala missense_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065955 c.235_237delTTGinsCC frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065993 p.Val67Ile missense_variant 0.14 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066024 c.168T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066042 c.150T>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066264 c.-73C>G upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066276 c.-85G>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066279 c.-88A>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066285 c.-96_-94delGCCinsCG upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066294 c.-103C>G upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066300 c.-109G>A upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066303 c.-112C>G upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066309 c.-118T>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066335 c.-144T>C upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066336 c.-145C>G upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066342 c.-151G>A upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066345 c.-154C>G upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066350 c.-159T>A upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066360 c.-169T>C upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066370 c.-180_-179delAGinsGC upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066380 c.-189A>G upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066390 c.-199C>G upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066395 c.-205_-204insACC upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066398 c.-210_-208delATT upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066748 c.-558_-557delCAinsAT upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066756 c.-565G>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066765 c.-574G>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066771 c.-580C>G upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066797 c.-606C>T upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067244 c.702C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067249 p.Thr233Ala missense_variant 0.2 para-aminosalicylic_acid
thyX 3067250 c.694_696delGTGinsAC frameshift_variant&missense_variant 0.2 para-aminosalicylic_acid
thyX 3067277 c.669C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067280 c.666G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067284 p.Ala221Asp missense_variant 0.19 para-aminosalicylic_acid
thyX 3067286 c.660C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067293 p.Gln218Arg missense_variant 0.2 para-aminosalicylic_acid
thyX 3067304 c.642A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067463 c.481_483delATCinsGA frameshift_variant&missense_variant 0.21 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067470 p.Asn159Ser missense_variant 0.22 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067640 c.306G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067643 c.303C>T synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067682 c.264G>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.33 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3074010 c.462C>A synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.3 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074334 c.138T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074339 p.Leu45Ile missense_variant 0.19 para-aminosalicylic_acid
thyA 3074349 c.123T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074360 c.112T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074361 c.111T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074372 p.Met34Leu missense_variant 0.19 para-aminosalicylic_acid
thyA 3074394 c.78C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074409 c.63C>A synonymous_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087649 p.Gly277Asp missense_variant 0.15 cycloserine
whiB7 3569197 c.-518C>A upstream_gene_variant 0.16 streptomycin
amikacin
kanamycin
whiB7 3569199 c.-520C>A upstream_gene_variant 0.16 streptomycin
amikacin
kanamycin
whiB7 3569250 c.-571T>G upstream_gene_variant 0.19 streptomycin
amikacin
kanamycin
Rv3236c 3612667 c.450T>G synonymous_variant 0.2 pyrazinamide
Rv3236c 3612673 c.444G>C synonymous_variant 0.2 pyrazinamide
Rv3236c 3612676 c.441A>G synonymous_variant 0.2 pyrazinamide
Rv3236c 3612685 c.432C>T synonymous_variant 0.22 pyrazinamide
Rv3236c 3612694 c.423T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
Rv3236c 3612814 c.303C>T synonymous_variant 1.0 pyrazinamide
lpqB 3623459 c.1452G>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3623465 c.1446G>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3623468 c.1443T>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623471 c.1440C>T synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3623474 c.1437C>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3623484 p.Phe476Tyr missense_variant 0.21 bedaquiline
rifampicin
lpqB 3623492 c.1419T>C synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3623512 p.Gly467Ser missense_variant 0.18 bedaquiline
rifampicin
lpqB 3623516 c.1395C>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3623528 c.1383G>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624094 c.817A>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624100 c.811T>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624119 c.792C>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624124 p.Leu263Val missense_variant 0.22 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624335 c.576C>T synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624339 p.Arg191His missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624346 p.Ser189Pro missense_variant 0.18 bedaquiline
rifampicin
lpqB 3624371 c.540T>G synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624389 c.522C>G synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3624401 c.510C>T synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624422 c.489G>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624425 p.Glu162Ala missense_variant 0.26 bedaquiline
rifampicin
lpqB 3624428 c.483A>G synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624452 c.459T>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624464 c.447A>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624470 c.441T>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.29 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>C synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.29 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624725 c.186G>C synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.22 bedaquiline
rifampicin Uncertain significance
lpqB 3624760 c.151C>T synonymous_variant 0.22 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625569 c.1045T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.24 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.28 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.26 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.19 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.23 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625882 c.732G>A synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625888 c.-978G>T upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625909 c.-999T>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626684 c.-71G>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.26 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626942 c.-329A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627215 c.135G>A synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
fbiB 3642593 c.1059G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiB 3642602 c.1068A>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiB 3642605 c.1071A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiB 3642614 c.1080C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642620 c.1086T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
rpoA 3877553 p.Glu319Gln missense_variant 0.18 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.31 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.22 rifampicin
rpoA 3877677 c.829_831delGCGinsAC frameshift_variant&missense_variant 0.22 rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.33 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.29 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.28 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.24 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.25 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.27 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.32 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.32 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.32 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.32 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.3 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.3 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.28 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.29 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.27 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.27 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.3 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.32 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.28 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.26 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.29 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.31 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.35 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.35 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.31 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.32 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.33 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.27 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.27 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.27 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.37 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.37 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.38 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.37 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.34 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.35 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.35 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.34 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.32 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.21 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.16 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.23 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878809 c.-302T>C upstream_gene_variant 0.19 rifampicin
rpoA 3878875 c.-368C>T upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878878 c.-371T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.23 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.23 rifampicin
rpoA 3878894 c.-387A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878908 c.-402_-401delACinsCG upstream_gene_variant 0.19 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878924 c.-417G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.2 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878989 c.-482G>C upstream_gene_variant 0.27 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.26 rifampicin
rpoA 3879012 c.-505C>T upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3879013 c.-506A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.25 rifampicin
rpoA 3879040 c.-533G>C upstream_gene_variant 0.25 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.31 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.25 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.2 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879149 c.-642C>G upstream_gene_variant 0.79 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.21 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.22 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.23 rifampicin
ddn 3986648 c.-196C>G upstream_gene_variant 0.19 delamanid
pretomanid
ddn 3986655 c.-189A>T upstream_gene_variant 0.17 delamanid
pretomanid
ddn 3986660 c.-184C>T upstream_gene_variant 0.16 delamanid
pretomanid
clpC1 4038271 p.Pro812Ala missense_variant 0.3 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.3 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAC frameshift_variant&missense_variant 0.24 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.32 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.31 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.21 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.27 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.31 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.29 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.31 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.22 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.22 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.36 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.48 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.33 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.3 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039289 c.1416T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.18 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039388 c.1317C>A synonymous_variant 0.27 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.27 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.26 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.37 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.32 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.42 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.22 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.24 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.25 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.26 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.29 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.44 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.46 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.49 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.48 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.29 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040264 c.441C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.24 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>A synonymous_variant 0.32 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040662 c.43C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
panD 4044096 c.186C>T synonymous_variant 0.16 pyrazinamide
panD 4044120 c.162A>G synonymous_variant 0.18 pyrazinamide
panD 4044123 c.159T>C synonymous_variant 0.18 pyrazinamide
panD 4044126 c.156T>C synonymous_variant 0.18 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>G synonymous_variant 0.22 pyrazinamide
panD 4044162 c.120A>G synonymous_variant 0.21 pyrazinamide
panD 4044703 c.-422C>G upstream_gene_variant 0.93 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.17 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.23 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.23 pyrazinamide
panD 4044749 c.-468G>A upstream_gene_variant 0.22 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.22 pyrazinamide
panD 4044755 c.-474G>C upstream_gene_variant 0.24 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.2 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.19 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
panD 4044886 c.-605A>G upstream_gene_variant 0.98 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.18 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.2 pyrazinamide
panD 4045025 c.-744C>G upstream_gene_variant 0.19 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.18 pyrazinamide
panD 4045034 c.-753A>T upstream_gene_variant 0.19 pyrazinamide
glpK 4138547 c.1209C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138551 p.Cys402Tyr missense_variant 0.85 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138568 c.1188A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138583 c.1173G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138586 c.1170C>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138594 p.Asn388Asp missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138622 c.1134C>T synonymous_variant 0.83 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138631 c.1125C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138715 c.1041G>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138747 c.1009C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138751 c.1005T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139554 p.Ala68Ser missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139575 p.Val61Ile missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139581 p.Asn59Asp missense_variant 0.26 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139630 c.126C>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139651 p.His35Gln missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4238879 c.-984G>A upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4240216 c.354T>C synonymous_variant 0.17 ethambutol
embC 4240543 c.681G>C synonymous_variant 0.21 ethambutol
embC 4240561 c.699C>G synonymous_variant 0.21 ethambutol
embC 4240573 c.711G>C synonymous_variant 0.16 ethambutol
embC 4240578 p.Ala239Val missense_variant 0.18 ethambutol
embC 4240582 c.720C>G synonymous_variant 0.21 ethambutol
embC 4240591 c.729C>G synonymous_variant 0.2 ethambutol
embC 4240594 c.732C>G synonymous_variant 0.2 ethambutol
embC 4240600 c.738G>C synonymous_variant 0.21 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.2 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.22 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.22 ethambutol
embC 4240654 c.792C>T synonymous_variant 0.21 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.2 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.27 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.25 ethambutol
embC 4240685 c.823_825delACCinsGG frameshift_variant&missense_variant 0.26 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.29 ethambutol
embC 4240706 p.Val282Thr missense_variant 0.28 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.37 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.38 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.38 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.39 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.38 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.31 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.31 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.29 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.29 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.27 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.22 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.21 ethambutol
embC 4240919 c.1057_1059delCTCinsTG frameshift_variant&missense_variant 0.22 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.2 ethambutol
embC 4240945 c.1083T>C synonymous_variant 0.19 ethambutol
embC 4240951 c.1089C>G synonymous_variant 0.19 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.18 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.19 ethambutol
embC 4240966 c.1104G>T synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4240979 p.Thr373Gln missense_variant 0.2 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.21 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.24 ethambutol
embC 4240996 c.1134G>C synonymous_variant 0.24 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.22 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.21 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.21 ethambutol
embC 4241035 c.1173G>A synonymous_variant 0.21 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.19 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.25 ethambutol
embC 4241137 c.1275G>C synonymous_variant 0.3 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.3 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.25 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.23 ethambutol
embC 4241443 c.1581C>G synonymous_variant 0.22 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.22 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.21 ethambutol
embC 4241473 c.1611G>A synonymous_variant 0.18 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.16 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.16 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 0.92 ethambutol Not assoc w R
embA 4245137 c.1905T>C synonymous_variant 0.27 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.28 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.31 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.29 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.28 ethambutol
embA 4245206 c.1974A>G synonymous_variant 0.25 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.25 ethambutol
embA 4245215 c.1983A>G synonymous_variant 0.24 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
embB 4245701 c.-813G>C upstream_gene_variant 0.18 ethambutol
embB 4245725 c.-789A>C upstream_gene_variant 0.2 ethambutol
embA 4245726 c.2494_2496delTTGinsCC frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
embB 4245737 c.-777A>C upstream_gene_variant 0.22 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.24 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.29 ethambutol
embA 4245771 p.Asn847Ser missense_variant 0.26 ethambutol Uncertain significance
embA 4245807 c.2575_2577delTTAinsCG frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
embA 4245820 p.Ser863Thr missense_variant 0.25 ethambutol
embB 4245830 c.-684G>C upstream_gene_variant 0.26 ethambutol
embB 4245845 c.-669T>G upstream_gene_variant 0.27 ethambutol
embB 4245848 c.-666C>G upstream_gene_variant 0.28 ethambutol
embB 4245860 c.-654C>G upstream_gene_variant 0.25 ethambutol
embA 4245885 p.Asp885Thr missense_variant 0.19 ethambutol
embA 4245892 p.Ile887Thr missense_variant 0.18 ethambutol Uncertain significance
embB 4245905 c.-609C>G upstream_gene_variant 0.18 ethambutol
embB 4246013 c.-501T>C upstream_gene_variant 0.16 ethambutol
embA 4246041 p.Asp937Asn missense_variant 0.18 ethambutol
embA 4246055 c.2823T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4246064 c.-450T>C upstream_gene_variant 0.2 ethambutol
embB 4246079 c.-435C>T upstream_gene_variant 0.18 ethambutol
embA 4246080 c.2848_2850delCCTinsTC frameshift_variant&missense_variant 0.18 ethambutol Uncertain significance
embA 4246088 c.2856A>G synonymous_variant 0.19 ethambutol Not assoc w R
embB 4246097 c.-417C>G upstream_gene_variant 0.18 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.16 ethambutol
embA 4246330 p.Thr1033Met missense_variant 0.17 ethambutol
embB 4246355 c.-159G>C upstream_gene_variant 0.2 ethambutol
embA 4246359 c.3127_3129delGCCinsCG frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
embB 4246364 c.-150G>C upstream_gene_variant 0.19 ethambutol
embB 4246367 c.-147C>T upstream_gene_variant 0.19 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.18 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.18 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.17 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.17 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.18 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.18 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.23 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.28 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.3 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.29 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.29 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.28 ethambutol
embB 4247536 c.1023C>G synonymous_variant 0.27 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.26 ethambutol
embB 4247746 c.1233C>A synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embB 4247776 c.1263G>T synonymous_variant 0.23 ethambutol
embB 4247779 c.1266C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247785 c.1272G>C synonymous_variant 0.19 ethambutol
embB 4247800 c.1287A>C synonymous_variant 0.19 ethambutol
embB 4247806 c.1293G>C synonymous_variant 0.2 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.2 ethambutol
embB 4247824 c.1311C>G synonymous_variant 0.18 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.23 ethambutol
embB 4248011 p.Ser500Ala missense_variant 0.27 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.26 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.25 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.25 ethambutol
embB 4248052 c.1539G>A synonymous_variant 0.24 ethambutol
embB 4248055 c.1542G>A synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4248064 c.1551G>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.33 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.31 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.29 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.3 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.33 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.35 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.34 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.34 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.32 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.32 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.32 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.32 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.29 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.23 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.23 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.23 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.23 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.23 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.18 ethambutol
embB 4248398 c.1885C>T synonymous_variant 0.17 ethambutol
embB 4249381 c.2868A>G synonymous_variant 0.16 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.2 ethambutol
aftB 4267607 c.1230G>A synonymous_variant 0.16 ethambutol
aftB 4267619 c.1218C>G synonymous_variant 0.17 ethambutol
aftB 4267622 c.1215G>C synonymous_variant 0.17 ethambutol
aftB 4267634 p.Arg401His missense_variant 0.16 ethambutol
aftB 4267637 c.1200C>G synonymous_variant 0.17 ethambutol
ubiA 4269001 p.Ala278Val missense_variant 0.29 ethambutol Uncertain significance
aftB 4269006 c.-170T>C upstream_gene_variant 0.29 ethambutol
aftB 4269009 c.-173A>G upstream_gene_variant 0.35 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.33 ethambutol
aftB 4269027 c.-191C>G upstream_gene_variant 0.32 ethambutol
aftB 4269033 c.-197T>C upstream_gene_variant 0.31 ethambutol
aftB 4269036 c.-200C>G upstream_gene_variant 0.31 ethambutol
aftB 4269042 c.-206G>C upstream_gene_variant 0.29 ethambutol
ubiA 4269075 c.757_759delATTinsGC frameshift_variant&missense_variant 0.18 ethambutol
aftB 4269081 c.-245G>C upstream_gene_variant 0.18 ethambutol
ubiA 4269088 p.Ala249Val missense_variant 0.15 ethambutol Uncertain significance
aftB 4269183 c.-347T>C upstream_gene_variant 0.27 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.32 ethambutol
ubiA 4269209 p.Ser209Ala missense_variant 0.31 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.23 ethambutol
ubiA 4269222 c.612T>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
aftB 4269225 c.-389C>G upstream_gene_variant 0.23 ethambutol
aftB 4269231 c.-395C>G upstream_gene_variant 0.22 ethambutol
aftB 4269234 c.-398A>G upstream_gene_variant 0.23 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.24 ethambutol
ethA 4328462 c.-989C>T upstream_gene_variant 0.19 ethionamide
ethA 4328471 c.-998A>G upstream_gene_variant 0.23 ethionamide
ethA 4328473 c.-1000G>C upstream_gene_variant 0.25 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R