TB-Profiler result

Run: ERR4831638
Summary

Run ID: ERR4831638

Sample name:

Date: 2024-04-15T19:00:28.637742

Number of reads: 266944

Percentage reads mapped: 18.04

Median coverage: 6.0

Strain: lineage1.1.1;lineage4

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.1 Indo-Oceanic RD239 0.5
lineage4 Euro-American None 0.68
lineage1 Indo-Oceanic RD239 0.23
lineage1.1.1 Indo-Oceanic RD239 0.28
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 771 c.771A>G synonymous_variant 0.74 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.65 isoniazid Uncertain significance
dnaA 801 c.801G>T synonymous_variant 0.61 isoniazid
dnaA 804 c.804G>C synonymous_variant 0.61 isoniazid
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.61 isoniazid Uncertain significance
dnaA 822 c.822A>G synonymous_variant 0.62 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.67 isoniazid Not assoc w R - Interim
dnaA 837 c.837A>G synonymous_variant 0.62 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.62 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.62 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.64 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.53 isoniazid Not assoc w R - Interim
dnaA 877 c.877T>C synonymous_variant 0.44 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.44 isoniazid
dnaA 888 c.888C>G synonymous_variant 0.47 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.54 isoniazid
dnaA 903 c.903C>G synonymous_variant 0.5 isoniazid Not assoc w R - Interim
gyrA 6673 c.-629A>C upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.59 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.59 levofloxacin Uncertain significance
moxifloxacin
gyrA 6739 c.-563C>T upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6754 c.-548C>T upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.71 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>G synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6838 c.-464C>T upstream_gene_variant 0.52 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 6872 c.1633_1635delTTGinsCT frameshift_variant&synonymous_variant 0.47 levofloxacin Uncertain significance
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6889 c.-413G>A upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.47 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>T upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7100 c.1861T>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7123 c.-179C>G upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrB 7126 c.1887G>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7129 c.-173T>G upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>C upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 7135 c.-167G>A upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>G upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>A upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7189 c.-113C>T upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrB 7198 c.1959C>T synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7412 c.111C>G synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7421 c.120G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7424 c.123G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7439 c.138C>T synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7451 c.150C>A synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7466 c.165G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 7511 c.210C>T synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7574 c.273G>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7589 c.288G>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>T synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>T synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8452 p.Ala384Val missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8792 c.1491G>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 8799 p.Ala500Ser missense_variant 0.71 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8817 p.Ser506Ala missense_variant 0.71 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8829 c.1528_1530delTTGinsCC frameshift_variant&missense_variant 0.71 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>G synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8840 c.1539C>T synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8846 c.1545C>T synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>T synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Lys missense_variant 0.62 levofloxacin
moxifloxacin
gyrA 8978 c.1677C>T synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8993 c.1692C>T synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.65 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.57 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9026 c.1725G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>T synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9063 p.Ser588Ala missense_variant 0.53 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
fgd1 491112 c.330G>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fgd1 491115 c.333G>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fgd1 491137 p.Glu119Ile missense_variant 0.67 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.67 clofazimine
pretomanid
delamanid
ccsA 620328 c.438G>C synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620338 c.448_450delACCinsGG frameshift_variant&missense_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>C synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620354 p.Trp155Tyr missense_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620365 p.Asn159Tyr missense_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>C synonymous_variant 0.64 capreomycin
amikacin
kanamycin
ccsA 620397 c.507C>G synonymous_variant 0.6 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.64 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.64 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.64 capreomycin
amikacin
kanamycin
ccsA 620430 c.540C>T synonymous_variant 0.64 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>G synonymous_variant 0.62 capreomycin
amikacin
kanamycin
nusG 734424 c.171G>A synonymous_variant 0.46 rifampicin
nusG 734445 c.192C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
nusG 734452 c.199_201delGAAinsCG frameshift_variant&missense_variant 0.5 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>A synonymous_variant 0.67 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
nusG 734493 c.240C>T synonymous_variant 0.71 rifampicin
nusG 734497 c.244_246delGTGinsAC frameshift_variant&missense_variant 0.71 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
nusG 734535 c.282C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
nusG 734794 p.Val181Ile missense_variant 0.7 rifampicin Uncertain significance
nusG 734807 p.Tyr185Phe missense_variant 0.8 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.8 rifampicin
nusG 734834 p.Met194Thr missense_variant 0.67 rifampicin Uncertain significance
nusG 734841 c.588G>T synonymous_variant 0.67 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.73 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.67 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.67 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.67 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.67 rifampicin
nusG 734864 p.Thr204Ser missense_variant 0.67 rifampicin
nusG 734893 p.Lys214Arg missense_variant 0.57 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.53 rifampicin
nusG 734928 c.675A>G synonymous_variant 0.54 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760110 c.304_306delTCTinsAGC synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760118 c.312T>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.64 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760274 p.Glu156Asp missense_variant 0.43 rifampicin Uncertain significance
rpoB 760276 p.Lys157Met missense_variant 0.43 rifampicin Uncertain significance
rpoB 760283 c.477G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.47 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.53 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.61 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760415 c.609C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.78 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760499 c.693G>A synonymous_variant 0.77 rifampicin
rpoB 760502 c.696C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.86 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760553 c.747C>G synonymous_variant 0.76 rifampicin
rpoB 760561 c.757_758delCG frameshift_variant 0.71 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.71 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.71 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.72 rifampicin
rpoB 760588 p.Thr261Ile missense_variant 0.75 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.78 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.78 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.79 rifampicin
rpoB 760608 c.802C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760668 c.862_864delACGinsGC frameshift_variant&missense_variant 0.53 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760817 c.1011A>G synonymous_variant 0.6 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.62 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760858 p.Val351Ala missense_variant 0.79 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760886 p.Glu360Asp missense_variant 0.89 rifampicin Uncertain significance
rpoB 760887 p.Thr361Val missense_variant 0.89 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760928 c.1122G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.89 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760979 c.1173G>A synonymous_variant 0.81 rifampicin
rpoB 760982 c.1176G>T synonymous_variant 0.79 rifampicin
rpoB 760985 c.1179G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.8 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.63 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.65 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAC frameshift_variant&missense_variant 0.68 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.66 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761231 c.1425C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>T synonymous_variant 0.65 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761297 c.1491C>T synonymous_variant 0.67 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.66 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.73 rifampicin
rpoB 761657 c.1851C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.69 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.69 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.67 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.65 rifampicin
rpoB 761693 c.1887G>C synonymous_variant 0.62 rifampicin
rpoB 761705 c.1899C>A synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761909 c.2103T>C synonymous_variant 0.63 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.63 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.63 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.6 rifampicin
rpoB 761924 c.2118G>A synonymous_variant 0.57 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.59 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.62 rifampicin
rpoB 761936 c.2130C>T synonymous_variant 0.64 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>A synonymous_variant 0.68 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.68 rifampicin Uncertain significance
rpoB 761969 c.2163G>A synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.87 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.88 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.84 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.84 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.84 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.86 rifampicin
rpoB 762158 c.2352G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.86 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.88 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.93 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762323 c.2517C>A synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.9 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.9 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.9 rifampicin
rpoB 762350 c.2544C>G synonymous_variant 0.89 rifampicin
rpoB 762353 c.2547C>T synonymous_variant 0.9 rifampicin
rpoB 762356 p.Glu850Asp missense_variant 0.9 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.94 rifampicin
rpoB 762368 p.Glu854Asp missense_variant 0.94 rifampicin
rpoC 762374 c.-996G>T upstream_gene_variant 0.94 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.94 rifampicin
rpoC 762383 c.-987C>G upstream_gene_variant 0.94 rifampicin
rpoC 762392 c.-978G>C upstream_gene_variant 0.94 rifampicin
rpoC 762395 c.-975G>T upstream_gene_variant 0.94 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.94 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762410 c.2604T>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762449 c.2643C>A synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.82 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.82 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 762533 c.-837T>C upstream_gene_variant 0.7 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.7 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.7 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.65 rifampicin
rpoC 762557 c.-813G>A upstream_gene_variant 0.57 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762866 c.3060C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.81 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 763145 c.3339G>A synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 763157 c.3351G>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763179 c.-191C>T upstream_gene_variant 0.64 rifampicin
rpoB 763193 c.3387C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>C synonymous_variant 0.93 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 763415 c.46_48delACCinsTG frameshift_variant&missense_variant 0.93 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.93 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCA frameshift_variant&missense_variant 0.93 rifampicin
rpoC 763433 c.64_66delCAAinsAC frameshift_variant&missense_variant 0.93 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.94 rifampicin
rpoC 763450 c.81G>A synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763609 c.240C>T synonymous_variant 0.89 rifampicin
rpoC 763621 c.252C>T synonymous_variant 0.9 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.79 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.79 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.79 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.79 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.79 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.72 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.71 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.71 rifampicin
rpoC 763816 c.447C>G synonymous_variant 0.44 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.5 rifampicin
rpoC 763836 p.Ala156Glu missense_variant 0.5 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.5 rifampicin
rpoC 763844 p.Arg159Lys missense_variant 0.5 rifampicin
rpoC 763857 p.Glu163Ala missense_variant 0.53 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.5 rifampicin
rpoC 763870 c.501C>T synonymous_variant 0.44 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.44 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.44 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.47 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.5 rifampicin Not assoc w R
rpoC 763886 c.517_519delCGGinsAT frameshift_variant&missense_variant 0.5 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.5 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.5 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763933 c.564C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.68 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.7 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.7 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.73 rifampicin
rpoC 763991 c.622_624delATCinsCT frameshift_variant&missense_variant 0.73 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.73 rifampicin
rpoC 763999 c.630C>T synonymous_variant 0.7 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.7 rifampicin
rpoC 764003 p.Ala212Ser missense_variant 0.7 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.78 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.75 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.75 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.76 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.76 rifampicin
rpoC 764054 c.685C>T synonymous_variant 0.83 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.86 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.79 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764362 c.993C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.71 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.78 rifampicin
rpoC 764428 c.1059G>T synonymous_variant 0.83 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.85 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.84 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764509 c.1140G>A synonymous_variant 0.72 rifampicin
rpoC 764510 c.1141C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>A synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>A synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.76 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764683 c.1314G>A synonymous_variant 0.88 rifampicin
rpoC 764692 c.1323C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.71 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.71 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.69 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.69 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765300 p.Val644Ala missense_variant 0.53 rifampicin Uncertain significance
rpoC 765305 p.Ile646Val missense_variant 0.53 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765323 c.1955_1957delGCC disruptive_inframe_deletion 0.57 rifampicin
rpoC 765328 p.His653Gln missense_variant 0.57 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.57 rifampicin Uncertain significance
rpoC 765334 c.1965C>T synonymous_variant 0.6 rifampicin
rpoC 765343 c.1974G>A synonymous_variant 0.59 rifampicin
rpoC 765352 c.1983G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765356 c.1987_1989delATGinsGC frameshift_variant&missense_variant 0.7 rifampicin
rpoC 765370 c.2001G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765379 c.2010G>C synonymous_variant 0.77 rifampicin
rpoC 765382 c.2013G>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.77 rifampicin Uncertain significance
rpoC 765403 c.2034G>C synonymous_variant 0.81 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.81 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 765449 c.2080_2082delGCCinsTG frameshift_variant&missense_variant 0.88 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 0.83 rifampicin
rpoC 765480 p.Tyr704Phe missense_variant 0.83 rifampicin Uncertain significance
rpoC 765499 c.2130C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 765517 c.2148C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.64 rifampicin
rpoC 765533 p.Tyr722His missense_variant 0.64 rifampicin Uncertain significance
rpoC 765895 c.2526G>A synonymous_variant 0.43 rifampicin
rpoC 765907 c.2538G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.37 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>G synonymous_variant 0.37 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766573 c.3204T>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766594 c.3225G>T synonymous_variant 0.63 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.68 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.68 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.72 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.72 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.72 rifampicin
rpoC 766642 c.3273C>T synonymous_variant 0.64 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.64 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.62 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.58 rifampicin
rpoC 766660 c.3291G>T synonymous_variant 0.58 rifampicin
rpoC 766661 p.Val1098Pro missense_variant 0.58 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.64 rifampicin
rpoC 766667 p.Ser1100Ala missense_variant 0.64 rifampicin Uncertain significance
rpoC 766672 c.3303T>C synonymous_variant 0.64 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 0.7 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.64 rifampicin
rpoC 766693 c.3324C>A synonymous_variant 0.64 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.54 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766975 c.3606C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Ser missense_variant 0.83 rifampicin Uncertain significance
rpoC 767191 c.3822C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 0.78 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.76 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767254 c.3885G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.54 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.5 streptomycin
rpsL 781658 c.99A>C synonymous_variant 0.5 streptomycin Not assoc w R - Interim
rpsL 781670 c.111G>C synonymous_variant 0.59 streptomycin
rpsL 781706 c.147T>C synonymous_variant 0.78 streptomycin
rpsL 781715 c.156T>G synonymous_variant 0.75 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.73 streptomycin
rpsL 781725 p.Lys56Arg missense_variant 0.69 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.69 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.69 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.75 streptomycin
rpsL 781737 p.Gln60Ala missense_variant 0.75 streptomycin
rpsL 781742 c.183C>G synonymous_variant 0.77 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.79 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.73 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.75 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.78 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.79 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.81 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.91 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.9 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.89 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.78 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.78 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.68 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.68 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.68 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.7 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.7 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.62 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.59 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.56 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.46 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.46 streptomycin
rplC 800645 c.-164C>G upstream_gene_variant 0.47 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.47 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.57 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.46 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.44 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.44 linezolid
rplC 800703 c.-106_-104delTTGinsCC upstream_gene_variant 0.41 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.42 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.41 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.41 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.46 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.46 linezolid
Rv1129c 1254543 c.-9T>G upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
sigE 1364718 c.306C>T synonymous_variant 0.53 pyrazinamide
sigE 1364726 p.Asn105Ser missense_variant 0.53 pyrazinamide
sigE 1364733 p.His107Gln missense_variant 0.53 pyrazinamide
sigE 1364742 c.330A>G synonymous_variant 0.57 pyrazinamide
sigE 1364751 c.339C>A synonymous_variant 0.62 pyrazinamide
sigE 1364757 c.345G>A synonymous_variant 0.62 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.64 pyrazinamide
sigE 1364778 c.366G>C synonymous_variant 0.62 pyrazinamide
sigE 1364782 c.370_372delGTCinsTG frameshift_variant&missense_variant 0.58 pyrazinamide Uncertain significance
sigE 1364790 c.378T>C synonymous_variant 0.58 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.77 pyrazinamide
sigE 1364814 c.402C>G synonymous_variant 0.77 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.83 pyrazinamide
sigE 1364838 c.426C>T synonymous_variant 0.82 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.82 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.75 pyrazinamide
atpE 1461132 p.Val30Ile missense_variant 0.8 bedaquiline
atpE 1461146 c.102G>T synonymous_variant 0.82 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.82 bedaquiline
atpE 1461161 c.117C>G synonymous_variant 0.83 bedaquiline
atpE 1461164 c.120C>T synonymous_variant 0.83 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.83 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.83 bedaquiline
atpE 1461179 c.135G>T synonymous_variant 0.83 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.83 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.77 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.79 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.73 bedaquiline
atpE 1461230 c.186G>T synonymous_variant 0.71 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.71 bedaquiline
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472846 n.1001C>T non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>C non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>C non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756A>C non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474415 n.759_781delCACACGCGCATACGCGCGTGTGA non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474743 n.1086T>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.78 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.7 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833547 c.6G>A synonymous_variant 0.6 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.71 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.71 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.71 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.76 pyrazinamide
rpsA 1833616 c.75A>T synonymous_variant 0.85 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.81 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.81 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.88 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.85 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.85 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.82 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.81 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.79 pyrazinamide
rpsA 1833697 c.156C>T synonymous_variant 0.79 pyrazinamide
rpsA 1833700 c.159C>T synonymous_variant 0.79 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.79 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.81 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.83 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.83 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.83 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.83 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.82 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.83 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.79 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.79 pyrazinamide
rpsA 1833823 c.282G>A synonymous_variant 0.79 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.84 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.84 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.84 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.85 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.87 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.86 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.84 pyrazinamide
rpsA 1833877 c.336C>G synonymous_variant 0.84 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.85 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.84 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.83 pyrazinamide
rpsA 1833958 c.417C>T synonymous_variant 0.83 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.83 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.84 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.83 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.82 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.8 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.8 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.78 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.79 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.83 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.83 pyrazinamide
rpsA 1834073 p.Lys178Arg missense_variant 0.71 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.64 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.64 pyrazinamide
rpsA 1834228 c.687C>A synonymous_variant 0.74 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.74 pyrazinamide
rpsA 1834234 c.693G>T synonymous_variant 0.74 pyrazinamide Not assoc w R - Interim
rpsA 1834240 c.699T>C synonymous_variant 0.75 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.77 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.77 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.75 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.81 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>T synonymous_variant 0.85 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.86 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.86 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.85 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.82 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.82 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>T synonymous_variant 0.81 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.76 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.73 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.74 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.74 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.74 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.75 pyrazinamide
rpsA 1834438 c.897C>T synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
rpsA 1834451 c.910T>C synonymous_variant 0.79 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.78 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.76 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.74 pyrazinamide
rpsA 1834516 c.975G>A synonymous_variant 0.72 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834520 c.979_981delGCCinsTG frameshift_variant&missense_variant 0.71 pyrazinamide Uncertain significance
rpsA 1834528 c.987T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.77 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.79 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.79 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.79 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.79 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.79 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.79 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.79 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.78 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.75 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834645 c.1104C>T synonymous_variant 0.76 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.78 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.78 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834700 p.Gln387Ala missense_variant 0.7 pyrazinamide
rpsA 1834705 c.1164C>G synonymous_variant 0.7 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.67 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.63 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.65 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.62 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.61 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.6 linezolid
tsnR 1853372 c.-234A>G upstream_gene_variant 0.55 linezolid
tsnR 1853375 c.-231G>C upstream_gene_variant 0.55 linezolid
tsnR 1853381 c.-225C>T upstream_gene_variant 0.55 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.55 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.55 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.55 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.5 linezolid
tsnR 1853417 c.-189G>C upstream_gene_variant 0.55 linezolid
tsnR 1853418 c.-188_-186delCTTinsTC upstream_gene_variant 0.55 linezolid
tsnR 1854045 p.Tyr147Cys missense_variant 1.0 linezolid Not assoc w R
kasA 2517917 c.-198G>C upstream_gene_variant 0.67 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.64 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.56 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.55 isoniazid
kasA 2518681 c.567C>T synonymous_variant 0.58 isoniazid
kasA 2518684 c.570C>A synonymous_variant 0.58 isoniazid
kasA 2518688 c.574_576delGTCinsAG frameshift_variant&missense_variant 0.58 isoniazid
kasA 2518691 p.Ala193Ile missense_variant 0.58 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.58 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.58 isoniazid
kasA 2518715 p.Pro201Met missense_variant 0.58 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.64 isoniazid
kasA 2518726 c.612G>C synonymous_variant 0.71 isoniazid
kasA 2518738 c.624G>C synonymous_variant 0.79 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.75 isoniazid
kasA 2518771 c.657C>G synonymous_variant 0.75 isoniazid
kasA 2518774 c.660C>T synonymous_variant 0.75 isoniazid
kasA 2518783 c.669T>G synonymous_variant 0.69 isoniazid
kasA 2518787 p.Arg225Lys missense_variant 0.67 isoniazid
kasA 2518792 c.678C>T synonymous_variant 0.67 isoniazid
kasA 2518795 c.681C>T synonymous_variant 0.67 isoniazid
kasA 2518798 c.684G>C synonymous_variant 0.67 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.73 isoniazid
ahpC 2726613 p.Asn141Asp missense_variant 0.62 isoniazid
ahpC 2726619 p.Glu143Ile missense_variant 0.62 isoniazid
ahpC 2726624 c.432C>T synonymous_variant 0.57 isoniazid Not assoc w R - Interim
ahpC 2726636 c.444G>C synonymous_variant 0.57 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.57 isoniazid
ahpC 2726642 c.450C>G synonymous_variant 0.57 isoniazid
ahpC 2726645 c.453C>A synonymous_variant 0.57 isoniazid
ahpC 2726651 c.459G>C synonymous_variant 0.57 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.57 isoniazid Not assoc w R - Interim
ahpC 2726666 c.474C>G synonymous_variant 0.5 isoniazid
ahpC 2726669 c.477T>C synonymous_variant 0.53 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.5 isoniazid
ahpC 2726678 c.486G>C synonymous_variant 0.5 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.47 isoniazid Not assoc w R - Interim
ahpC 2726687 c.495C>T synonymous_variant 0.47 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.47 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.47 isoniazid
ahpC 2726717 c.525A>C synonymous_variant 0.44 isoniazid
Rv2477c 2783311 c.732T>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>T synonymous_variant 0.69 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783347 c.696C>T synonymous_variant 0.69 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783377 c.666C>G synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783380 c.663C>T synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>A synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783404 c.639C>T synonymous_variant 0.82 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783407 c.636C>G synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783419 c.624G>C synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783432 p.Ser204Thr missense_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626717 c.-104C>T upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrA 3626741 c.609C>G synonymous_variant 0.67 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626756 c.594C>G synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626762 c.588G>C synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626786 c.564A>G synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626804 c.546A>G synonymous_variant 0.75 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626825 c.525T>A synonymous_variant 0.76 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626843 c.-230G>T upstream_gene_variant 0.77 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.75 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627073 c.277C>T synonymous_variant 0.68 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 0.72 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627110 c.-497G>C upstream_gene_variant 0.72 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.68 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>G upstream_gene_variant 0.68 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.78 bedaquiline
rifampicin
mtrA 3627133 p.Ala73Ser missense_variant 0.68 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrB 3627143 c.-530G>C upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrB 3627149 c.-536G>A upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrB 3627167 c.-554T>G upstream_gene_variant 0.68 bedaquiline
rifampicin
mtrB 3627170 c.-557C>G upstream_gene_variant 0.71 bedaquiline
rifampicin
rpoA 3877542 c.966C>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877545 c.963G>C synonymous_variant 0.47 rifampicin
rpoA 3877554 c.954G>C synonymous_variant 0.62 rifampicin
rpoA 3877560 c.948C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsAC frameshift_variant&missense_variant 0.61 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3877614 c.894G>A synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3877620 c.888G>A synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877665 c.843C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877677 c.831G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.7 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.69 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.68 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.65 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.67 rifampicin
rpoA 3877758 c.750G>C synonymous_variant 0.67 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.62 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.71 rifampicin
rpoA 3877797 c.711G>A synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3877815 c.693C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.79 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.87 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.73 rifampicin Uncertain significance
rpoA 3877974 c.534G>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877977 p.Lys177Asn missense_variant 0.73 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.47 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.5 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.5 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.5 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.5 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.5 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.5 rifampicin
rpoA 3878091 c.417C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3878102 p.Val136Ile missense_variant 0.67 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.67 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.77 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.74 rifampicin
rpoA 3878142 p.Gly122Asp missense_variant 0.78 rifampicin Uncertain significance
rpoA 3878154 c.354G>A synonymous_variant 0.79 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.95 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.95 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.92 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3878343 c.165C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.9 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.89 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.88 rifampicin
rpoA 3878373 c.135G>C synonymous_variant 0.94 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
clpC1 4038767 c.1938G>T synonymous_variant 0.59 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.59 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.59 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.61 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.65 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.56 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.6 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.67 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.67 pyrazinamide
clpC1 4038860 c.1845G>T synonymous_variant 0.74 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.84 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.72 pyrazinamide
clpC1 4038911 c.1794G>C synonymous_variant 0.72 pyrazinamide
clpC1 4038914 c.1791G>T synonymous_variant 0.73 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.73 pyrazinamide
clpC1 4038923 c.1782A>T synonymous_variant 0.73 pyrazinamide
clpC1 4038928 c.1777C>A synonymous_variant 0.73 pyrazinamide
clpC1 4038929 c.1776G>A synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4038932 c.1773G>C synonymous_variant 0.77 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.77 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.77 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.77 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.78 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.68 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.69 pyrazinamide
clpC1 4038992 c.1713C>T synonymous_variant 0.72 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.69 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.78 pyrazinamide
clpC1 4039061 c.1644G>C synonymous_variant 0.76 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.76 pyrazinamide
clpC1 4039077 p.Lys543Arg missense_variant 0.77 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.77 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.77 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.77 pyrazinamide
clpC1 4039094 c.1611C>T synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
clpC1 4039097 c.1608G>T synonymous_variant 0.77 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.77 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.79 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.85 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.87 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.87 pyrazinamide
clpC1 4039165 c.1540C>T synonymous_variant 0.85 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.85 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.85 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.84 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.84 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.8 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.77 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.76 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.76 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.77 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4039265 c.1440C>T synonymous_variant 0.63 pyrazinamide
clpC1 4039271 c.1434G>A synonymous_variant 0.63 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.6 pyrazinamide
clpC1 4039286 c.1417_1419delCTTinsTA frameshift_variant&synonymous_variant 0.52 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.58 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.65 pyrazinamide
clpC1 4039316 p.Glu463Asp missense_variant 0.66 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.66 pyrazinamide Not assoc w R - Interim
clpC1 4039328 c.1377A>G synonymous_variant 0.66 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.66 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.65 pyrazinamide
clpC1 4039347 p.Arg453Ser missense_variant 0.64 pyrazinamide
clpC1 4039360 p.Ser449Arg missense_variant 0.63 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.63 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.64 pyrazinamide
clpC1 4039391 c.1314T>C synonymous_variant 0.65 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.73 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.73 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.76 pyrazinamide Uncertain significance
clpC1 4039427 c.1278G>A synonymous_variant 0.75 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.75 pyrazinamide
clpC1 4039436 c.1269G>A synonymous_variant 0.79 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.75 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.78 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.78 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.78 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.78 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.79 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.79 pyrazinamide
clpC1 4039528 c.1177C>A synonymous_variant 0.79 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.82 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.81 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.79 pyrazinamide
clpC1 4039565 c.1140G>T synonymous_variant 0.76 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.75 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.77 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.76 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.7 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.7 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.72 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.74 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.77 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.78 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.78 pyrazinamide
clpC1 4039733 c.972G>T synonymous_variant 0.77 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.79 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.78 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.79 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.83 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.85 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.86 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.88 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.91 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.9 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.9 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.88 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.88 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.88 pyrazinamide
clpC1 4039868 c.837C>T synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4039913 c.792C>T synonymous_variant 0.94 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.85 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.84 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.84 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.85 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.85 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.85 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
clpC1 4040009 c.696C>G synonymous_variant 0.81 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.8 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.8 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.8 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.75 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>C synonymous_variant 0.86 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.9 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>T synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
clpC1 4040141 c.564C>T synonymous_variant 0.8 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.8 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.79 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.77 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4040168 c.537G>C synonymous_variant 0.71 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.71 pyrazinamide
clpC1 4040174 c.531C>T synonymous_variant 0.71 pyrazinamide
clpC1 4040300 c.405C>T synonymous_variant 0.67 pyrazinamide
clpC1 4040309 c.396C>T synonymous_variant 0.74 pyrazinamide
clpC1 4040333 c.372G>C synonymous_variant 0.74 pyrazinamide
clpC1 4040342 c.363C>A synonymous_variant 0.74 pyrazinamide
clpC1 4040348 c.357G>T synonymous_variant 0.74 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.71 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.71 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.63 pyrazinamide
clpC1 4040366 c.339C>T synonymous_variant 0.63 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.63 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.6 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.6 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.62 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.65 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.69 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.7 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.7 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.71 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.68 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.66 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.61 pyrazinamide
clpC1 4040462 c.243C>T synonymous_variant 0.64 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.64 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.69 pyrazinamide Not assoc w R - Interim
clpC1 4040495 c.210C>T synonymous_variant 0.69 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.84 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.83 pyrazinamide
clpC1 4040540 c.165G>T synonymous_variant 0.82 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.83 pyrazinamide
clpC1 4040558 c.147G>C synonymous_variant 0.76 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.76 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.74 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.73 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.68 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.68 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.68 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.7 pyrazinamide
clpC1 4040642 c.61_63delAGGinsCC frameshift_variant&missense_variant 0.6 pyrazinamide
glpK 4138556 c.1200G>C synonymous_variant 0.6 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138579 c.1177C>T synonymous_variant 0.6 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138601 c.1155G>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138616 c.1140G>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>A synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.69 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138664 c.1092G>C synonymous_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.55 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138688 c.1068C>T synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138694 p.Pro354Glu missense_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138712 p.Ala348Asp missense_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.6 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1030_1032delGCAinsTG frameshift_variant&missense_variant 0.6 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240756 c.894G>C synonymous_variant 0.8 ethambutol
embC 4240819 c.957A>C synonymous_variant 1.0 ethambutol
embC 4240826 p.Ala322Ser missense_variant 1.0 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.91 ethambutol