TB-Profiler result

Run: SRR6458421
Summary

Run ID: SRR6458421

Sample name:

Date: 2024-04-15T15:18:06.098888

Number of reads: 1298659

Percentage reads mapped: 70.54

Median coverage: 50.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.93
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.97
lineage2.2 East-Asian (Beijing) RD105;RD207 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Ser450Leu Assoc w R
rpoC p.Leu527Val Uncertain significance Mutation from literature
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
p.His312Arg Mutation from literature
pyrazinamide pncA p.Gly97Ser Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin eis c.-10G>A Assoc w R Can only confer resistance if genetically linked to a functional Eis
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.24 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.48 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761155 p.Ser450Leu missense_variant 0.59 rifampicin Assoc w R
rpoC 764948 p.Leu527Val missense_variant 0.81 rifampicin Uncertain significance Mutation from literature
rpsL 781687 p.Lys43Arg missense_variant 0.77 streptomycin Assoc w R
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.35 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.27 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 0.93 isoniazid Assoc w R High-level resistance
pncA 2288953 p.Gly97Ser missense_variant 1.0 pyrazinamide Assoc w R
eis 2715342 c.-10G>A upstream_gene_variant 1.0 kanamycin Assoc w R Can only confer resistance if genetically linked to a functional Eis
embB 4247429 p.Met306Val missense_variant 0.66 ethambutol Assoc w R
embB 4247448 p.His312Arg missense_variant 0.37 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 708 c.708T>C synonymous_variant 0.19 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.22 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.23 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.21 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.22 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.21 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.29 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.31 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.3 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.3 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.3 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.31 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.31 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.3 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.34 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.33 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.33 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.29 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.32 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.31 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.31 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.32 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.31 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.31 isoniazid
dnaA 942 c.942C>G synonymous_variant 0.29 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.31 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.32 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.3 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.26 isoniazid
dnaA 975 c.975G>C synonymous_variant 0.26 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>G synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.25 isoniazid
dnaA 996 c.996A>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 1002 c.1002G>A synonymous_variant 0.25 isoniazid
dnaA 1005 c.1005G>C synonymous_variant 0.25 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 1020 c.1020C>G synonymous_variant 0.22 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.21 isoniazid
dnaA 1035 c.1035A>G synonymous_variant 0.26 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.21 isoniazid
dnaA 1050 c.1050G>C synonymous_variant 0.22 isoniazid
dnaA 1053 c.1053C>G synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 1059 c.1059C>G synonymous_variant 0.22 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.24 isoniazid
dnaA 1071 c.1071C>G synonymous_variant 0.25 isoniazid
dnaA 1074 c.1074C>G synonymous_variant 0.25 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.34 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.32 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.31 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.35 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.35 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.33 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.32 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.32 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.32 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.31 isoniazid
dnaA 1177 p.Ala393Ser missense_variant 0.31 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.3 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.29 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.28 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.28 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.26 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.22 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.23 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.24 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.25 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.25 isoniazid
dnaA 1293 c.1293T>G synonymous_variant 0.23 isoniazid
dnaA 1302 c.1302C>G synonymous_variant 0.25 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.27 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.25 isoniazid
dnaA 1329 c.1329A>C synonymous_variant 0.23 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 1335 c.1335G>A synonymous_variant 0.21 isoniazid
dnaA 1338 c.1338T>C synonymous_variant 0.21 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.24 isoniazid
dnaA 1356 c.1356T>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 1359 c.1359G>A synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 1365 c.1365C>G synonymous_variant 0.25 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.24 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.24 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.24 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.2 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.19 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.2 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.21 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.2 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.2 isoniazid
dnaA 1419 c.1419C>G synonymous_variant 0.21 isoniazid
dnaA 1431 c.1431A>G synonymous_variant 0.21 isoniazid
gyrB 6190 c.951A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.22 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6400 c.-902C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.37 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.44 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6931 c.-371A>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6934 c.-368A>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 6937 c.1698G>A synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6955 c.-347G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6970 c.-332C>T upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6973 c.1734G>A synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6976 c.-326A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7000 c.-302C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 7012 c.1773G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7018 c.-284G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7021 c.-281G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.28 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7727 c.426G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7862 c.561C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7883 c.582G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7884 c.583_585delCGTinsGC frameshift_variant&missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7919 p.Glu206Asp missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7923 p.His208Tyr missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7928 p.Asp209Glu missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7942 p.Glu214Ala missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7955 c.654G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7958 c.657C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7963 p.Gly221Glu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7970 c.669T>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7976 c.675C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7979 c.678G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7991 c.690C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7992 c.691_693delGCCinsTG frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7997 c.696A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8010 p.Ser237Thr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8020 p.Thr240Ile missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8024 c.723T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8027 c.726T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8036 c.735A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8039 c.738T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8054 c.753T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8057 c.756A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8081 c.780A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8084 c.783G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8099 c.798T>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364Leu missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8438 c.1137C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8498 c.1197C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8535 p.Glu412Gln missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8720 c.1419G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8732 c.1431G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8951 c.1650G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.28 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9281 c.1980C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9542 c.2241T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9548 c.2247T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 490902 c.120T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 490968 c.186C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 490974 c.192T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 490998 c.216T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491010 c.228C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491031 c.249C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491038 p.Ile86Val missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491077 p.Asn99Gly missense_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491137 p.Glu119Gln missense_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491331 c.549G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 574650 c.-698A>C upstream_gene_variant 0.24 ethionamide
isoniazid
mshA 574655 c.-693C>G upstream_gene_variant 0.23 ethionamide
isoniazid
mshA 574664 c.-684G>C upstream_gene_variant 0.24 ethionamide
isoniazid
mshA 574671 c.-677_-675delGCAinsCTG upstream_gene_variant 0.24 ethionamide
isoniazid
mshA 574676 c.-672G>C upstream_gene_variant 0.23 ethionamide
isoniazid
mshA 574683 c.-665T>C upstream_gene_variant 0.21 ethionamide
isoniazid Uncertain significance
mshA 575689 c.342G>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.23 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.28 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.28 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575767 c.420G>A synonymous_variant 0.26 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.26 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.94 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620249 p.Ser120Cys missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620631 c.741T>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620710 p.Val274Met missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620730 c.840C>T synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>G synonymous_variant 0.25 capreomycin
amikacin
kanamycin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.98 ethionamide Uncertain significance
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.17 ethionamide
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.19 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.2 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.2 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.21 ethionamide
Rv0565c 657686 c.-216C>G upstream_gene_variant 0.22 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.22 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.25 ethionamide
Rv0565c 657719 c.-249C>G upstream_gene_variant 0.32 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.34 ethionamide
hadA 731681 c.-249A>C upstream_gene_variant 0.18 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.29 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.18 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.18 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.18 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.2 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.22 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.22 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.24 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.33 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.3 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.3 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.3 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.28 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.26 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.25 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.31 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.33 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.33 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.33 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.41 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.32 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734595 c.342C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734596 c.343T>C synonymous_variant 0.26 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.28 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.28 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734832 c.579C>G synonymous_variant 0.27 rifampicin
nusG 734841 c.588G>A synonymous_variant 0.25 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.25 rifampicin
nusG 734853 c.600A>C synonymous_variant 0.23 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.23 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.24 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.23 rifampicin
rpoB 760139 c.333A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.22 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.28 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.35 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.33 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.33 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.32 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.32 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.33 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.29 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.26 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.22 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760555 p.Glu250Ala missense_variant 0.23 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.23 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.33 rifampicin
rpoB 760602 p.Glu266Gln missense_variant 0.33 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.33 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.42 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.42 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.39 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.36 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.35 rifampicin
rpoB 760763 c.957C>T synonymous_variant 0.36 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.36 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.36 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.36 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.39 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.38 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.4 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.4 rifampicin
rpoB 760821 c.1015C>T synonymous_variant 0.4 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.48 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.49 rifampicin
rpoB 760869 p.Val355Ile missense_variant 0.52 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.52 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.61 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.6 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.64 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.73 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.76 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.54 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.54 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.33 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.33 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.33 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.29 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.48 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761360 c.1554T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.42 rifampicin
rpoB 761373 p.Val523His missense_variant 0.34 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.39 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.31 rifampicin
rpoB 761437 p.Ala544Asp missense_variant 0.31 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.31 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.31 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.3 rifampicin
rpoB 761452 p.Val549Ala missense_variant 0.3 rifampicin
rpoB 761457 c.1651_1653delCCGinsGC frameshift_variant&missense_variant 0.3 rifampicin
rpoB 761462 c.1656C>G synonymous_variant 0.3 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.34 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.35 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.33 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.27 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.28 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.24 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.24 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.24 rifampicin
rpoB 761723 c.1917_1919delAGAinsG frameshift_variant&synonymous_variant 0.23 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.22 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.25 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.25 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.25 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.23 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.25 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.25 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.24 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.24 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.23 rifampicin
rpoB 761847 p.Cys681Ser missense_variant 0.22 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.2 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.2 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>G synonymous_variant 0.21 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.2 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.21 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.21 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.22 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.22 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.21 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.21 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.35 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.36 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.35 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762027 c.2221_2223delCTCinsTG frameshift_variant&missense_variant 0.36 rifampicin
rpoB 762032 c.2226C>G synonymous_variant 0.35 rifampicin
rpoB 762035 c.2229G>C synonymous_variant 0.37 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.36 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.34 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.33 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.37 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.33 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.26 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762347 c.2541T>C synonymous_variant 0.23 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.25 rifampicin
rpoC 762521 c.-849C>G upstream_gene_variant 0.18 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.15 rifampicin
rpoB 762860 c.3054G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.26 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.68 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.33 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.29 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.33 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.3 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.28 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.27 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.28 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763220 c.-150G>C upstream_gene_variant 0.31 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.32 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763268 c.3462C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763284 c.-86C>T upstream_gene_variant 0.26 rifampicin
rpoB 763316 c.3510T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763322 c.-48G>T upstream_gene_variant 0.18 rifampicin
rpoC 763343 c.-27T>C upstream_gene_variant 0.19 rifampicin
rpoC 763351 c.-19T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoC 763352 c.-18T>A upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoC 763402 c.33C>G synonymous_variant 0.19 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.24 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.23 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.41 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.41 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.33 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.35 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.37 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.35 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.34 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.26 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.27 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.27 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.29 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.26 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.22 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.2 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.2 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.24 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.23 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.23 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.23 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.21 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.25 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.25 rifampicin
rpoC 763919 c.550C>T synonymous_variant 0.32 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.27 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.28 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.28 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.29 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.27 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.28 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.32 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.33 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.38 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.41 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764116 c.747C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.4 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.39 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.37 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.37 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.33 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.27 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.28 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.25 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.32 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.31 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.3 rifampicin
rpoC 764398 c.1029G>C synonymous_variant 0.31 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.33 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.32 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.31 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.41 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.38 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTG frameshift_variant&missense_variant 0.33 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.34 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.35 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.34 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.25 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.25 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.29 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.27 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.21 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765349 c.1980T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.28 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.26 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.28 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.28 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.26 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.26 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765535 c.2166C>T synonymous_variant 0.34 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.33 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.34 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.34 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.37 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.36 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.35 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.33 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.41 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.42 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.44 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.45 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.44 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.4 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.4 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.38 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.39 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.39 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.38 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.36 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.33 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.3 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.28 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.28 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.25 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.23 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766274 p.Ala969Thr missense_variant 0.17 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.21 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.23 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.22 rifampicin
rpoC 766327 c.2958C>G synonymous_variant 0.24 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.24 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.27 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.26 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.24 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.29 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.3 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.34 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.38 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.38 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.39 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.44 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.45 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.45 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.49 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.48 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.52 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.49 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.48 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.49 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.54 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.56 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.63 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.6 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.6 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.58 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.59 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.48 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.45 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.48 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.42 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.39 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.39 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.41 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.42 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.37 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.34 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.32 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.31 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.37 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.36 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.26 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.25 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.22 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767248 c.3879C>T synonymous_variant 0.2 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775898 c.2583G>A synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775901 c.2580G>A synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.2 clofazimine
bedaquiline
mmpL5 775912 c.2569C>A synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.21 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.2 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.23 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.25 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.27 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.26 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.26 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.27 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.29 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.3 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.32 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.3 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.31 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.34 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.34 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.33 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.33 streptomycin Uncertain significance
rplC 800537 c.-272C>T upstream_gene_variant 0.19 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.22 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.22 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.24 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.25 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.28 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.28 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.29 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.29 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.36 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.37 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.37 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.4 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.42 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.41 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.39 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.37 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.34 linezolid
rplC 800794 c.-15_-9delAGATTGGinsGAGTT upstream_gene_variant 0.33 linezolid
rplC 800814 c.6A>G synonymous_variant 0.33 linezolid
rplC 800817 c.9A>T synonymous_variant 0.33 linezolid
rplC 800844 c.36T>C synonymous_variant 0.32 linezolid
rplC 800865 c.57A>G synonymous_variant 0.24 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.24 linezolid
rplC 800874 c.66A>G synonymous_variant 0.22 linezolid
rplC 800877 c.69A>C synonymous_variant 0.21 linezolid
rplC 800880 c.72A>G synonymous_variant 0.22 linezolid
rplC 800889 c.81C>G synonymous_variant 0.22 linezolid
rplC 800907 c.99C>G synonymous_variant 0.17 linezolid
rplC 801127 p.Ala107Thr missense_variant 0.15 linezolid
rplC 801183 c.375C>A synonymous_variant 0.19 linezolid
rplC 801222 c.414T>C synonymous_variant 0.24 linezolid
rplC 801228 c.420T>C synonymous_variant 0.25 linezolid
rplC 801246 c.438C>G synonymous_variant 0.26 linezolid
rplC 801249 c.441T>G synonymous_variant 0.25 linezolid
rplC 801255 c.447C>T synonymous_variant 0.22 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303534 p.Ser202Ala missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303560 c.630G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303611 c.681G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303660 p.Val244Thr missense_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303701 c.771C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303716 c.786C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.37 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.28 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304080 p.Ala384Ser missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304523 c.1593G>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304628 c.1698G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Glu missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.25 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304893 p.Gly655Ser missense_variant 0.16 clofazimine
pretomanid
delamanid
sigE 1364667 c.255T>C synonymous_variant 0.2 pyrazinamide
sigE 1364676 c.264C>G synonymous_variant 0.21 pyrazinamide
sigE 1364679 c.267T>C synonymous_variant 0.21 pyrazinamide
sigE 1364691 c.279T>C synonymous_variant 0.24 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.24 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.23 pyrazinamide
sigE 1364727 c.315C>T synonymous_variant 0.24 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.25 pyrazinamide
sigE 1364748 c.336G>C synonymous_variant 0.29 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.27 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.26 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.29 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.28 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.31 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.31 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.31 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.31 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.25 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.26 pyrazinamide
sigE 1364866 c.454_456delGCTinsTG frameshift_variant&missense_variant 0.26 pyrazinamide Uncertain significance
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.24 pyrazinamide Uncertain significance
sigE 1364904 p.Asp164Glu missense_variant 0.21 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.634_649delTTTCCTCTCCGGAGGAinsC non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
inhA 1673607 c.-595T>C upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673610 c.-592C>T upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673616 c.-586A>G upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.2 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.23 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673658 c.-544G>A upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.23 ethionamide
isoniazid
inhA 1673664 c.-538A>G upstream_gene_variant 0.24 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.25 ethionamide
isoniazid
inhA 1673679 c.-523T>G upstream_gene_variant 0.31 ethionamide
isoniazid
inhA 1673709 c.-493C>T upstream_gene_variant 0.25 ethionamide
isoniazid
fabG1 1673710 c.271_273delCTAinsAC frameshift_variant&missense_variant 0.25 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.26 ethionamide
isoniazid
inhA 1673730 c.-472C>G upstream_gene_variant 0.26 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.26 ethionamide
isoniazid
inhA 1673742 c.-460C>G upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673750 p.Lys104Arg missense_variant 0.23 ethionamide
isoniazid
inhA 1674368 p.Ala56Glu missense_variant 0.19 ethionamide
isoniazid
inhA 1674379 c.178C>T synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674382 p.Leu61Ile missense_variant 0.19 ethionamide
isoniazid
inhA 1674415 p.Ala72Thr missense_variant 0.16 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.21 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.24 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.27 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674693 c.492C>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.2 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.32 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.33 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.28 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.39 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.48 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.48 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.51 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.51 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.45 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.45 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.46 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.46 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.33 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.28 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.28 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834201 c.660C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.42 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.42 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.42 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.43 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.46 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834594 c.1053C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.37 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.34 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.26 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.25 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.21 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.34 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.32 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.35 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.35 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.36 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.37 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.33 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.34 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.3 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.3 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.3 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.23 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064933 c.-205A>G upstream_gene_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064936 c.-208C>A upstream_gene_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064945 c.-217G>A upstream_gene_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064963 c.-235G>C upstream_gene_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-253_-251delGGCinsCT upstream_gene_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517947 c.-168C>T upstream_gene_variant 0.27 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.25 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.22 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.18 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.27 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.27 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.3 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.31 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.32 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.32 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.34 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.36 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.39 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.43 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.44 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.41 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.41 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.4 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.44 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.45 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.45 isoniazid
kasA 2518690 c.576C>T synonymous_variant 0.44 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.45 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.46 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.47 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.43 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.44 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.52 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.49 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.5 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.46 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.45 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.45 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.43 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.49 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.48 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.41 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.38 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.37 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.38 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.33 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.27 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.23 isoniazid
kasA 2518927 c.813C>G synonymous_variant 0.17 isoniazid
folC 2747359 c.240C>G synonymous_variant 0.18 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783320 c.723C>T synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783332 c.711T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783365 c.678C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783373 p.Glu224Gln missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783416 c.625_627delATCinsGG frameshift_variant&missense_variant 0.25 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783422 c.621T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.616_618delCCCinsGG frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783432 p.Ser204Ala missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783434 c.609C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.43 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784330 c.-288G>A upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784357 c.-316_-315delTTinsAC upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784366 c.-324G>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784375 c.-333T>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784381 c.-339T>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784390 c.-348G>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784428 c.-386T>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784455 c.-413A>C upstream_gene_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3064962 c.1230C>A synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064973 p.Ala407Ser missense_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064980 c.1212C>A synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066350 c.-159T>A upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067376 c.570G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067463 c.481_483delATCinsGA frameshift_variant&missense_variant 0.27 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067470 p.Asn159Ser missense_variant 0.29 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067500 p.Lys149Arg missense_variant 0.33 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.32 para-aminosalicylic_acid
thyX 3067526 c.420C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.28 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.24 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.21 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.21 para-aminosalicylic_acid
thyX 3067560 p.Arg129His missense_variant 0.21 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.22 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.22 para-aminosalicylic_acid
thyX 3067571 c.375C>T synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067577 p.Glu123Asp missense_variant 0.24 para-aminosalicylic_acid
thyX 3067582 p.Met122Leu missense_variant 0.27 para-aminosalicylic_acid
thyX 3067586 c.360C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067601 c.345G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067604 c.342G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067610 p.Lys112Asn missense_variant 0.24 para-aminosalicylic_acid
thyX 3067613 c.333G>A synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067640 c.306G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067643 c.303C>T synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067682 c.264G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073874 p.Ile200Val missense_variant 0.19 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3074010 c.462C>A synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.34 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074117 c.355C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074120 c.352T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074199 c.273G>A synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.22 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074217 c.255T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074235 c.237C>T synonymous_variant 0.18 para-aminosalicylic_acid
ald 3086731 c.-89A>G upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624166 p.Met249Leu missense_variant 0.26 bedaquiline
rifampicin
lpqB 3624172 p.Val247Ile missense_variant 0.26 bedaquiline
rifampicin
lpqB 3624173 c.738A>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624188 c.723G>C synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624191 c.720C>G synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624194 c.717C>A synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624200 c.711A>G synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624209 c.702A>C synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624224 c.687T>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624241 c.670C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624242 c.669A>G synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624245 c.666A>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624401 c.510C>T synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.2 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625313 p.Arg434Lys missense_variant 0.16 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.28 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.25 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.26 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.28 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.29 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.3 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626684 c.-71G>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.21 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>T upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.38 bedaquiline