TB-Profiler result

Run: ERR4796577
Summary

Run ID: ERR4796577

Sample name:

Date: 2024-10-03T15:30:27.246379

Number of reads: 1003782

Percentage reads mapped: 25.0

Median coverage: 16.0

Strain:

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.2.2 Indo-Oceanic RD239 0.98
lineage1.2.2.2 Indo-Oceanic RD239 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid inhA c.-778A>G Assoc w R - Interim Alias fabG1_c.-16A>G. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
p.Ile21Thr Uncertain significance Mutation from literature
ethambutol
pyrazinamide
streptomycin rpsL p.Lys88Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-778A>G Assoc w R - Interim Alias fabG1_c.-16A>G
c.-777C>T Assoc w R Alias fabG1_c.-15C>T
p.Ile21Thr Uncertain significance Mutation from literature
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpsL 781822 p.Lys88Arg missense_variant 0.44 streptomycin Assoc w R
inhA 1673424 c.-778A>G upstream_gene_variant 1.0 ethionamide Assoc w R - Interim Alias fabG1_c.-16A>G
isoniazid Assoc w R - Interim Alias fabG1_c.-16A>G. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 ethionamide Assoc w R Alias fabG1_c.-15C>T
isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
inhA 1674263 p.Ile21Thr missense_variant 1.0 ethionamide Uncertain significance Mutation from literature
isoniazid Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6700 c.-602T>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6733 c.-569G>A upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6739 c.-563C>G upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6749 p.Ala504Ser missense_variant 0.67 levofloxacin
moxifloxacin
gyrA 6754 c.-548C>T upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrB 6764 p.Leu509Phe missense_variant 0.68 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6794 p.Ile519Leu missense_variant 0.45 levofloxacin
moxifloxacin
gyrB 6798 p.Gly520Ala missense_variant 0.45 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6805 c.1566G>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6808 c.1569C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 7100 c.1861T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7123 c.-179C>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 7124 p.Ser629Glu missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7190 c.-112C>T upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7198 c.-104C>G upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrB 7209 p.Asp657Ala missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7213 c.-89G>A upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7216 c.-86G>T upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8366 c.1065G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8846 c.1545C>T synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8849 c.1548C>G synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>G synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8858 c.1557T>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.83 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8913 p.Lys538Arg missense_variant 0.88 levofloxacin
moxifloxacin
gyrA 8921 c.1620C>T synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Lys missense_variant 0.91 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8982 p.Cys561Ser missense_variant 0.91 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.88 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.86 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>T synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>G synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.64 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13699 c.-141A>G upstream_gene_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
nusG 734439 c.186C>G synonymous_variant 0.47 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.55 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.55 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.55 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.55 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.61 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.68 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
nusG 734543 p.Arg97Pro missense_variant 0.62 rifampicin
nusG 734548 p.Gln99Lys missense_variant 0.62 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.62 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
nusG 734600 p.Thr116Asn missense_variant 0.57 rifampicin Uncertain significance
nusG 734607 p.Asp118Glu missense_variant 0.57 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.59 rifampicin
nusG 734615 p.Ala121Gly missense_variant 0.57 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.55 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.55 rifampicin
nusG 734637 c.384G>T synonymous_variant 0.38 rifampicin
rpoB 760091 c.285G>A synonymous_variant 0.45 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>C synonymous_variant 0.59 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.59 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760120 p.Arg105His missense_variant 0.62 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.75 rifampicin Uncertain significance
rpoB 760139 c.333A>C synonymous_variant 0.76 rifampicin
rpoB 760140 p.Pro112Ser missense_variant 0.73 rifampicin
rpoB 760145 c.339C>G synonymous_variant 0.78 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.78 rifampicin
rpoB 760157 c.351A>G synonymous_variant 0.82 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760233 c.427_429delAGTinsTCG synonymous_variant 0.7 rifampicin
rpoB 760241 c.435G>C synonymous_variant 0.7 rifampicin
rpoB 760253 c.447T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760265 p.Met153Ile missense_variant 0.65 rifampicin
rpoB 760274 p.Glu156Asp missense_variant 0.52 rifampicin Uncertain significance
rpoB 760282 p.Thr159Ser missense_variant 0.48 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760472 c.666C>T synonymous_variant 0.82 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760496 c.690G>A synonymous_variant 0.88 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.8 rifampicin
rpoB 760515 p.Trp237Met missense_variant 0.8 rifampicin
rpoB 760522 p.Ser239Thr missense_variant 0.71 rifampicin
rpoB 760527 p.Gln241Glu missense_variant 0.71 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760534 p.Val243Ala missense_variant 0.71 rifampicin
rpoB 760538 p.Glu244Asp missense_variant 0.75 rifampicin
rpoB 760547 c.741G>A synonymous_variant 0.71 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760616 p.Asp270Glu missense_variant 0.71 rifampicin Uncertain significance
rpoB 760617 p.Ile271Val missense_variant 0.71 rifampicin
rpoB 760625 c.819C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760640 c.834C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760665 p.Gln287Glu missense_variant 0.74 rifampicin
rpoB 760669 p.Thr288Asn missense_variant 0.74 rifampicin
rpoB 760673 c.867G>T synonymous_variant 0.77 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.68 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.65 rifampicin
rpoB 760958 c.1152G>C synonymous_variant 0.38 rifampicin
rpoB 760965 p.Met387Leu missense_variant 0.42 rifampicin Uncertain significance
rpoB 760985 c.1179G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.5 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.82 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.81 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.85 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.53 rifampicin
rpoB 761174 c.1368T>C synonymous_variant 0.5 rifampicin
rpoB 761178 c.1372_1374delTCAinsAGC synonymous_variant 0.53 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.55 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.57 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.48 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.76 rifampicin
rpoB 761603 c.1797C>A synonymous_variant 0.76 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.76 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.76 rifampicin
rpoB 761650 p.Ser615Asn missense_variant 0.73 rifampicin
rpoB 761655 p.Ala617Ser missense_variant 0.73 rifampicin
rpoB 761666 c.1860G>T synonymous_variant 0.76 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.7 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.32 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.3 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.3 rifampicin
rpoB 761789 c.1983G>C synonymous_variant 0.29 rifampicin
rpoB 761790 p.Arg662Asp missense_variant 0.29 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.48 rifampicin
rpoB 761816 c.2010C>G synonymous_variant 0.48 rifampicin
rpoB 761819 c.2013G>C synonymous_variant 0.46 rifampicin
rpoB 761834 c.2028T>G synonymous_variant 0.56 rifampicin
rpoB 761847 p.Cys681Arg missense_variant 0.59 rifampicin Uncertain significance
rpoB 761852 c.2046C>G synonymous_variant 0.57 rifampicin
rpoB 761863 p.Ala686Glu missense_variant 0.61 rifampicin
rpoB 761868 p.Asp688Gln missense_variant 0.62 rifampicin
rpoB 761873 c.2067A>T synonymous_variant 0.62 rifampicin
rpoB 761891 c.2085G>A synonymous_variant 0.62 rifampicin
rpoB 761892 p.Ile696Leu missense_variant 0.62 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.6 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.56 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.57 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.59 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.68 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.76 rifampicin
rpoB 761942 c.2136C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762000 c.2194_2195delTCinsAG synonymous_variant 0.9 rifampicin
rpoB 762003 p.Asn733Gln missense_variant 0.9 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.9 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Thr missense_variant 0.91 rifampicin Uncertain significance
rpoB 762053 c.2247T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.73 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.76 rifampicin Uncertain significance
rpoB 762137 c.2331C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.76 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.77 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.84 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.84 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.85 rifampicin
rpoB 762269 c.2463G>A synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762318 p.Ser838Thr missense_variant 0.83 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762335 c.2529C>T synonymous_variant 0.76 rifampicin
rpoB 762336 p.Ile844Val missense_variant 0.75 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.83 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.79 rifampicin
rpoB 762348 c.2542_2543delTCinsAG synonymous_variant 0.79 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.84 rifampicin
rpoB 762368 p.Glu854Asp missense_variant 0.84 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.84 rifampicin
rpoB 762375 p.Ala857Pro missense_variant 0.85 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.86 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.88 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762410 c.2604T>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 762426 p.Ser874Gln missense_variant 0.71 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.68 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762485 c.2679G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.61 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.59 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.59 rifampicin Uncertain significance
rpoC 762527 c.-843G>C upstream_gene_variant 0.57 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.5 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.44 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.44 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 0.47 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.42 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.68 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.68 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.68 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762814 p.Met1003Thr missense_variant 0.71 rifampicin Uncertain significance
rpoB 762818 c.3012C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 762830 c.-540C>T upstream_gene_variant 0.76 rifampicin
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762858 p.Thr1018Ser missense_variant 0.65 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762878 p.Ile1024Met missense_variant 0.7 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.7 rifampicin Uncertain significance
rpoB 762899 c.3093G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 762917 c.-453C>T upstream_gene_variant 0.74 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 762971 c.-399G>C upstream_gene_variant 0.71 rifampicin
rpoC 762980 c.-390T>C upstream_gene_variant 0.72 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.74 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.87 rifampicin
rpoC 763022 c.-348C>G upstream_gene_variant 0.86 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763053 c.-317_-315delTTGinsCTC upstream_gene_variant 0.87 rifampicin
rpoC 763058 c.-312C>G upstream_gene_variant 0.89 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.88 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 1.0 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763619 p.Arg84Lys missense_variant 0.72 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.75 rifampicin
rpoC 763648 c.279C>G synonymous_variant 0.71 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.8 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.8 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.86 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.86 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.86 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.86 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.85 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.79 rifampicin
rpoC 763786 c.417C>G synonymous_variant 0.74 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.73 rifampicin
rpoC 763796 p.Met143Leu missense_variant 0.72 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.55 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.47 rifampicin
rpoC 763884 p.Ala172Val missense_variant 1.0 rifampicin Not assoc w R
rpoC 763886 c.517C>A synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 764134 c.765C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764143 c.774G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764147 p.Ser260Ala missense_variant 0.5 rifampicin Uncertain significance
rpoC 764153 p.Gln262Lys missense_variant 0.52 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.5 rifampicin
rpoC 764162 p.Ile265Leu missense_variant 0.48 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.59 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.61 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.66 rifampicin Uncertain significance
rpoC 764215 c.846A>G synonymous_variant 0.66 rifampicin
rpoC 764216 p.Asn283Ser missense_variant 0.66 rifampicin
rpoC 764227 c.858G>C synonymous_variant 0.71 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.71 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.78 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.79 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>C synonymous_variant 0.82 rifampicin
rpoC 764297 p.Met310Leu missense_variant 0.82 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.85 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.79 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.84 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGT synonymous_variant 0.83 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.82 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.89 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTTG synonymous_variant 0.91 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.91 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.89 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.78 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.78 rifampicin
rpoC 764656 c.1287C>G synonymous_variant 0.79 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764690 p.Cys441Ala missense_variant 0.67 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.69 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764763 p.His465Leu missense_variant 0.73 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.74 rifampicin
rpoC 764803 c.1434C>G synonymous_variant 0.74 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.72 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.74 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.73 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.65 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCTC synonymous_variant 0.65 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.65 rifampicin
rpoC 764902 c.1533C>G synonymous_variant 0.65 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.52 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764956 c.1587T>C synonymous_variant 0.66 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>G synonymous_variant 0.61 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.61 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.61 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.61 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>A synonymous_variant 0.62 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.54 rifampicin
rpoC 765121 c.1752G>T synonymous_variant 0.47 rifampicin
rpoC 765379 c.2010G>C synonymous_variant 0.56 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.59 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.68 rifampicin
rpoC 765408 p.Gly680Glu missense_variant 0.71 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.74 rifampicin
rpoC 765417 p.Phe683Tyr missense_variant 0.74 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 0.74 rifampicin
rpoC 765435 p.His689Pro missense_variant 0.74 rifampicin
rpoC 765443 p.Val692Arg missense_variant 0.85 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.77 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765496 c.2127C>G synonymous_variant 0.75 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766280 p.Ser971Gly missense_variant 0.79 rifampicin
rpoC 766288 c.2919C>T synonymous_variant 0.77 rifampicin
rpoC 766299 p.Thr977Met missense_variant 0.77 rifampicin
rpoC 766312 c.2943T>G synonymous_variant 0.74 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.74 rifampicin
rpoC 766333 c.2964G>C synonymous_variant 0.79 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.8 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 766361 p.Val998Ile missense_variant 0.8 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.8 rifampicin
rpoC 766369 c.3000C>A synonymous_variant 0.8 rifampicin
rpoC 766375 c.3006C>G synonymous_variant 0.8 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.8 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.83 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 766390 c.3021C>T synonymous_variant 0.83 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 766432 c.3063T>C synonymous_variant 0.65 rifampicin
rpoC 766435 p.Glu1022Asp missense_variant 0.65 rifampicin Uncertain significance
rpoC 766684 c.3315C>G synonymous_variant 0.5 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.58 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.59 rifampicin
rpoC 766718 p.Asp1117Asn missense_variant 0.65 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.68 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.7 rifampicin
rpoC 766742 p.Gln1125Met missense_variant 0.7 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.68 rifampicin
rpoC 766754 p.Glu1129Gln missense_variant 0.7 rifampicin
rpoC 766763 p.Ile1132Val missense_variant 0.73 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.71 rifampicin
rpoC 766775 p.Arg1136Asn missense_variant 0.71 rifampicin
rpoC 766792 c.3423C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 766798 c.3429C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 766799 p.Ala1144Ser missense_variant 0.71 rifampicin Uncertain significance
rpoC 766804 c.3435A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766969 c.3600C>G synonymous_variant 0.81 rifampicin
rpoC 766990 c.3621G>C synonymous_variant 0.87 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767017 c.3648C>G synonymous_variant 0.85 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.85 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.83 rifampicin
rpoC 767065 c.3696G>C synonymous_variant 0.83 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.85 rifampicin
rpoC 767080 c.3711G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 767087 p.Cys1240Ser missense_variant 0.84 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.83 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781652 c.93T>C synonymous_variant 0.55 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.44 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.42 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.44 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.44 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.44 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.42 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.42 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.36 streptomycin
rpsL 781845 p.Lys96Arg missense_variant 0.36 streptomycin
rpsL 781851 p.Ile98Val missense_variant 0.34 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.33 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.33 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.3 streptomycin
rpsL 781884 p.Asn109Asp missense_variant 0.32 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.33 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.29 streptomycin
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.66 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471928 n.83T>G non_coding_transcript_exon_variant 0.66 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471930 n.85_89delGGAGAinsTTGCAGGG non_coding_transcript_exon_variant 0.66 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471980 n.135G>C non_coding_transcript_exon_variant 0.82 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471981 n.136C>A non_coding_transcript_exon_variant 0.83 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.89 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>A non_coding_transcript_exon_variant 0.89 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.89 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>T non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195T>A non_coding_transcript_exon_variant 0.92 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472043 n.198T>G non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472055 n.211delG non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472060 n.215T>G non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472067 n.222G>T non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472068 n.223T>G non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>T non_coding_transcript_exon_variant 0.94 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.92 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472287 n.442C>G non_coding_transcript_exon_variant 0.82 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472288 n.443A>T non_coding_transcript_exon_variant 0.82 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472289 n.444T>A non_coding_transcript_exon_variant 0.82 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472298 n.453delGinsCC non_coding_transcript_exon_variant 0.8 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.8 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472304 n.461_471delTCTCTCGGATT non_coding_transcript_exon_variant 0.8 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472325 n.480G>T non_coding_transcript_exon_variant 0.8 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472326 n.481T>G non_coding_transcript_exon_variant 0.8 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472327 n.482G>C non_coding_transcript_exon_variant 0.8 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472445 n.601dupT non_coding_transcript_exon_variant 0.98 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472449 n.604_607delCACGinsGCA non_coding_transcript_exon_variant 0.98 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>A non_coding_transcript_exon_variant 0.96 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>A non_coding_transcript_exon_variant 0.99 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.97 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.95 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472680 n.835C>T non_coding_transcript_exon_variant 0.95 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.9 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472841 n.996G>A non_coding_transcript_exon_variant 0.91 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.79 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472960 n.1115G>A non_coding_transcript_exon_variant 0.82 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.84 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472986 n.1141C>T non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.87 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.95 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474253 n.596A>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474638 n.981C>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1474675 n.1018C>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1052G>A non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474710 n.1053T>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474716 n.1059_1060delAAinsGAG non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474721 n.1064G>A non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474740 n.1083G>C non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474747 n.1090C>G non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475065 n.1408G>C non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475066 n.1409C>G non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475067 n.1410A>C non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>G non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475080 n.1423G>C non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475081 n.1424C>G non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475381 n.1724G>C non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1475404 n.1747A>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475422 n.1765A>G non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1475427 n.1772delG non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1475433 n.1776A>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1475440 n.1783T>A non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1475443 n.1786G>C non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1475444 n.1787G>A non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475481 n.1824C>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475485 n.1828C>T non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475772 n.2115A>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.88 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>A non_coding_transcript_exon_variant 0.87 capreomycin
linezolid Uncertain significance
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.91 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.91 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476309 n.2652G>T non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867_2868insT non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1476531 n.2874T>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833628 c.87G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.55 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.6 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.6 pyrazinamide
rpsA 1833682 c.141C>T synonymous_variant 0.58 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.6 pyrazinamide
rpsA 1833697 c.156C>A synonymous_variant 0.6 pyrazinamide
rpsA 1833700 c.159C>T synonymous_variant 0.6 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.63 pyrazinamide
rpsA 1833712 c.171C>T synonymous_variant 0.63 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.63 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.69 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.72 pyrazinamide
rpsA 1833769 c.228C>G synonymous_variant 0.76 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.7 pyrazinamide
rpsA 1833782 p.Ser81Asn missense_variant 0.7 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.72 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.78 pyrazinamide
rpsA 1833817 c.276C>T synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
rpsA 1833829 c.288A>G synonymous_variant 0.79 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.82 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.83 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.83 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.89 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.89 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.87 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.88 pyrazinamide
rpsA 1833894 p.Ala118Asp missense_variant 0.88 pyrazinamide
rpsA 1833898 c.357C>G synonymous_variant 0.88 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.94 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.85 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.86 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.87 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.87 pyrazinamide
rpsA 1833997 c.456G>A synonymous_variant 0.87 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.87 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.86 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.84 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.83 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.74 pyrazinamide
rpsA 1834129 c.588C>G synonymous_variant 0.71 pyrazinamide
rpsA 1834135 c.594G>C synonymous_variant 0.65 pyrazinamide
rpsA 1834151 p.Asn204His missense_variant 0.59 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.59 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
rpsA 1834164 c.623_624insGGGGC frameshift_variant 0.57 pyrazinamide Uncertain significance
rpsA 1834167 c.627_631delCACCA frameshift_variant 0.59 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
rpsA 1834183 c.642T>C synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
rpsA 1834192 c.651C>G synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.78 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.76 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.75 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.78 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.78 pyrazinamide
rpsA 1834258 c.717G>A synonymous_variant 0.78 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.76 pyrazinamide
rpsA 1834282 c.741C>T synonymous_variant 0.76 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834298 p.Gln253Thr missense_variant 0.73 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.69 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.66 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>G synonymous_variant 0.59 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.56 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.56 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.56 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.59 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.58 pyrazinamide
rpsA 1834432 c.891G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.7 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.74 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.74 pyrazinamide
rpsA 1834477 c.936C>A synonymous_variant 0.74 pyrazinamide
rpsA 1834483 p.Glu314Asp missense_variant 0.74 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.76 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.75 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.83 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.85 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.86 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.86 pyrazinamide
rpsA 1834556 p.Ala339Ser missense_variant 0.86 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.79 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.78 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.8 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.81 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834657 c.1116G>A synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
rpsA 1834667 p.Ala376Ser missense_variant 0.84 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.76 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.79 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.78 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.59 linezolid
tsnR 1853372 c.-234A>G upstream_gene_variant 0.57 linezolid
tsnR 1853375 c.-231G>C upstream_gene_variant 0.57 linezolid
tsnR 1853381 c.-225C>T upstream_gene_variant 0.57 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.59 linezolid
tsnR 1853387 c.-219T>C upstream_gene_variant 0.59 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.61 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.68 linezolid
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
katG 2155674 c.438G>A synonymous_variant 0.54 isoniazid
katG 2155680 c.432G>A synonymous_variant 0.67 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.64 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.69 isoniazid
katG 2155719 c.393G>C synonymous_variant 0.69 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.67 isoniazid
katG 2155742 p.Gly124Arg missense_variant 0.67 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.67 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.67 isoniazid
katG 2155752 c.360C>T synonymous_variant 0.67 isoniazid
katG 2155758 c.354C>T synonymous_variant 0.67 isoniazid
katG 2155764 p.His116Glu missense_variant 0.67 isoniazid
katG 2155769 p.Ile115Val missense_variant 0.57 isoniazid
katG 2155770 c.342C>G synonymous_variant 0.57 isoniazid
katG 2155782 c.330C>G synonymous_variant 0.62 isoniazid
katG 2155785 p.Ala109Ser missense_variant 0.62 isoniazid
katG 2155796 p.Ala106Ser missense_variant 0.62 isoniazid
katG 2155806 c.306T>C synonymous_variant 0.53 isoniazid
Rv1979c 2223553 c.-389C>A upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Not assoc w R
kasA 2517917 c.-198G>C upstream_gene_variant 0.56 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.44 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0 isoniazid
ahpC 2726418 p.Glu76Lys missense_variant 1.0 isoniazid Uncertain significance
ahpC 2726638 p.Ala149Val missense_variant 0.39 isoniazid
ahpC 2726651 c.459G>C synonymous_variant 0.37 isoniazid
ahpC 2726654 c.462G>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
ahpC 2726657 c.465A>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
ahpC 2726663 c.471C>T synonymous_variant 0.37 isoniazid
ahpC 2726669 c.477T>C synonymous_variant 0.37 isoniazid
ahpC 2726676 c.484C>T synonymous_variant 0.39 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.39 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.37 isoniazid
Rv2477c 2783473 c.570A>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783488 c.555G>A synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783497 c.544_546delTTGinsCTC synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.5 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783516 c.526_527delTCinsAG synonymous_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.5 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783578 p.Glu155Ser missense_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783584 p.Ala153Gly missense_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783587 c.456G>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
thyA 3074031 c.441T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074034 c.438T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.37 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.38 para-aminosalicylic_acid
thyA 3074058 c.414C>T synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074076 c.396C>A synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3074089 p.Ile128Asn missense_variant 0.43 para-aminosalicylic_acid
thyA 3074094 c.378G>A synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3074110 p.Thr121Ser missense_variant 0.45 para-aminosalicylic_acid
thyA 3074115 c.357G>C synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3074121 p.Asp117Glu missense_variant 0.45 para-aminosalicylic_acid
thyA 3074124 c.348G>C synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.48 para-aminosalicylic_acid
thyA 3074135 p.Ser113Gly missense_variant 0.48 para-aminosalicylic_acid
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625714 c.-804C>G upstream_gene_variant 0.57 rifampicin
bedaquiline
mtrB 3625721 p.Arg298Gln missense_variant 0.57 rifampicin Uncertain significance
bedaquiline
lpqB 3625723 c.-813C>G upstream_gene_variant 0.57 rifampicin
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625733 p.Asn294Gly missense_variant 0.57 rifampicin
bedaquiline
mtrB 3625750 p.Gln288His missense_variant 0.57 rifampicin
bedaquiline
mtrB 3625753 p.Ala287Thr missense_variant 0.57 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 p.Arg284Lys missense_variant 0.62 rifampicin
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.67 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625825 c.-915C>T upstream_gene_variant 0.62 rifampicin
bedaquiline
mtrB 3626467 c.147G>A synonymous_variant 1.0 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.38 rifampicin
rpoA 3877600 p.Gln303Ala missense_variant 0.35 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.53 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.53 rifampicin
rpoA 3877629 c.879C>G synonymous_variant 0.5 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.58 rifampicin
rpoA 3877665 c.843C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.64 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.82 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.81 rifampicin
rpoA 3877740 c.768G>C synonymous_variant 0.79 rifampicin
rpoA 3877752 p.Asp252Glu missense_variant 0.87 rifampicin
rpoA 3877765 p.Ala248Ser missense_variant 0.88 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3877800 c.708G>C synonymous_variant 0.87 rifampicin
rpoA 3877827 p.Val227Thr missense_variant 0.83 rifampicin
rpoA 3877836 c.672A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>C synonymous_variant 0.85 rifampicin
rpoA 3877847 c.661C>T synonymous_variant 0.79 rifampicin
rpoA 3877856 c.652T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoA 3877860 c.648C>G synonymous_variant 0.82 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.79 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.79 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.75 rifampicin
rpoA 3877898 p.Pro204Ala missense_variant 0.67 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.73 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.68 rifampicin
rpoA 3877929 p.Ile193Val missense_variant 0.7 rifampicin Uncertain significance
rpoA 3877935 p.Lys191Arg missense_variant 0.7 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.62 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.61 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877992 c.516C>G synonymous_variant 0.63 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.52 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.52 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.52 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.52 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.52 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.52 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>C synonymous_variant 0.52 rifampicin
rpoA 3878046 c.462T>A synonymous_variant 0.53 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.55 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.56 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.56 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.58 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.58 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3878102 p.Val136Ile missense_variant 0.64 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.64 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.68 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.74 rifampicin
rpoA 3878124 c.384G>C synonymous_variant 0.72 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.75 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.75 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.74 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.84 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoA 3878185 p.Gly108Ala missense_variant 0.83 rifampicin
rpoA 3878188 p.Ala107Gly missense_variant 0.8 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Thr missense_variant 0.8 rifampicin
rpoA 3878199 c.309T>C synonymous_variant 0.78 rifampicin
rpoA 3878217 p.Leu97Val missense_variant 0.77 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.65 rifampicin
rpoA 3878251 c.256_257delTCinsAG synonymous_variant 0.65 rifampicin
rpoA 3878259 c.249G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3878264 p.Ser82Gly missense_variant 0.56 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
clpC1 4038704 c.2001T>C synonymous_variant 0.53 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.59 pyrazinamide
clpC1 4038710 c.1995G>A synonymous_variant 0.62 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.76 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.74 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.73 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.73 pyrazinamide
clpC1 4038779 c.1924_1926delCTCinsTTG synonymous_variant 0.7 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.71 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.74 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.79 pyrazinamide
clpC1 4038810 p.Gln632Ser missense_variant 0.81 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.81 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.81 pyrazinamide
clpC1 4038836 c.1869G>C synonymous_variant 0.82 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4038896 c.1809C>G synonymous_variant 0.79 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.8 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.81 pyrazinamide
clpC1 4038914 c.1791G>T synonymous_variant 0.81 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.81 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.81 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.81 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.85 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4038983 c.1722C>T synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4038986 p.Asp573Glu missense_variant 0.85 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
clpC1 4039009 c.1696C>T synonymous_variant 0.88 pyrazinamide
clpC1 4039016 c.1689C>G synonymous_variant 0.87 pyrazinamide
clpC1 4039021 c.1684C>T synonymous_variant 0.88 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.88 pyrazinamide
clpC1 4039046 c.1659C>A synonymous_variant 0.9 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.92 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4039082 c.1623C>T synonymous_variant 0.91 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.91 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.94 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.98 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 0.97 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.95 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.95 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.95 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.93 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.9 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCTC synonymous_variant 0.9 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.9 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.9 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.93 pyrazinamide
clpC1 4039223 c.1482C>T synonymous_variant 0.81 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.75 pyrazinamide
clpC1 4039277 c.1428C>G synonymous_variant 0.65 pyrazinamide
clpC1 4039280 c.1425G>C synonymous_variant 0.64 pyrazinamide
clpC1 4039286 p.Leu473Met missense_variant 0.64 pyrazinamide
clpC1 4039293 c.1411_1412insTG frameshift_variant 0.59 pyrazinamide
clpC1 4039296 c.1407_1408delTT frameshift_variant 0.59 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.5 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>G synonymous_variant 0.48 pyrazinamide
clpC1 4039327 p.Gln460Glu missense_variant 0.48 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.5 pyrazinamide
clpC1 4039334 c.1371G>T synonymous_variant 0.5 pyrazinamide
clpC1 4039337 c.1368A>C synonymous_variant 0.5 pyrazinamide
clpC1 4039340 c.1365G>A synonymous_variant 0.5 pyrazinamide
clpC1 4039347 p.Arg453Lys missense_variant 0.5 pyrazinamide
clpC1 4039352 c.1353C>A synonymous_variant 0.46 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.57 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>C synonymous_variant 0.85 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039552 c.1153C>T synonymous_variant 0.96 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.89 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.86 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.86 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.86 pyrazinamide Not assoc w R - Interim
clpC1 4039582 p.Thr375Ser missense_variant 0.87 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039601 p.Ala368Ser missense_variant 0.82 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.81 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.82 pyrazinamide
clpC1 4039654 p.Thr351Ser missense_variant 0.74 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.79 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.78 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.8 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039700 c.1005C>T synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4039724 c.981A>G synonymous_variant 0.82 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.81 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.75 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.74 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.75 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.75 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.73 pyrazinamide
clpC1 4039766 c.939T>G synonymous_variant 0.75 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.73 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.73 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.7 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.73 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.73 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.67 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.65 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.65 pyrazinamide
clpC1 4039856 c.849C>T synonymous_variant 0.68 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.69 pyrazinamide
clpC1 4039883 c.822G>A synonymous_variant 0.63 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.7 pyrazinamide
clpC1 4039916 c.789T>C synonymous_variant 0.64 pyrazinamide
clpC1 4039925 c.780C>G synonymous_variant 0.66 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.68 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.64 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.66 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.67 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.63 pyrazinamide
clpC1 4039996 p.Glu237Lys missense_variant 0.65 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.64 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.65 pyrazinamide
clpC1 4040021 c.684A>G synonymous_variant 0.66 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.67 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.67 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.67 pyrazinamide
clpC1 4040072 c.633C>T synonymous_variant 0.66 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.62 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4040117 c.588A>G synonymous_variant 0.52 pyrazinamide
clpC1 4040135 c.570C>T synonymous_variant 0.48 pyrazinamide
clpC1 4040138 c.567G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.43 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040279 c.426C>G synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.68 pyrazinamide
clpC1 4040300 c.405C>T synonymous_variant 0.68 pyrazinamide
clpC1 4040306 c.399G>A synonymous_variant 0.61 pyrazinamide
clpC1 4040310 p.Thr132Asn missense_variant 0.56 pyrazinamide
clpC1 4040315 p.Glu130Asp missense_variant 0.53 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.4 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.45 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.62 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.66 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.68 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.68 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.69 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.68 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.61 pyrazinamide
clpC1 4040432 c.271_273delAGCinsTCG synonymous_variant 0.61 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.65 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.62 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4040453 c.252C>A synonymous_variant 0.58 pyrazinamide
clpC1 4040456 c.249C>G synonymous_variant 0.58 pyrazinamide
clpC1 4040459 c.246C>G synonymous_variant 0.58 pyrazinamide
clpC1 4040462 c.243C>G synonymous_variant 0.6 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.6 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
clpC1 4040517 p.Val63Ala missense_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.35 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4241042 p.Asn394Asp missense_variant 1.0 ethambutol Not assoc w R
embA 4245969 p.Pro913Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
ethA 4326439 p.Asn345Lys missense_variant 1.0 ethionamide Uncertain significance
ethA 4327126 p.Trp116Cys missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407848 p.Ala119Thr missense_variant 1.0 streptomycin Uncertain significance