TB-Profiler result

Run: ERR4831616
Summary

Run ID: ERR4831616

Sample name:

Date: 2024-10-04T00:05:02.522271

Number of reads: 666728

Percentage reads mapped: 44.16

Median coverage: 21.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.96
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.97
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Gln432Arg Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Gln432Arg Mutation from literature
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin rpsL p.Lys88Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761101 p.Gln432Arg missense_variant 0.71 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rifampicin Mutation from literature
rpsL 781822 p.Lys88Arg missense_variant 0.59 streptomycin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1389 c.1389C>T synonymous_variant 1.0 isoniazid Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6769 c.-533C>T upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.26 levofloxacin
moxifloxacin
gyrB 6808 c.1569C>T synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.31 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7397 c.96G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7433 c.132G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7631 c.330G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7637 c.336C>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8191 p.Ala297Gly missense_variant 0.45 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8198 c.897T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8222 c.921C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8225 c.924T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCTG synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8240 c.939C>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8246 c.945C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8247 p.Ile316Val missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 p.Ile328Leu missense_variant 0.43 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8535 p.Glu412Gln missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8600 c.1299G>A synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8633 c.1332C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491499 c.717G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491512 p.Asn244Glu missense_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491542 c.760T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491563 c.781_783delAGCinsTCG synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491571 c.789C>T synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491595 c.813C>T synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>G synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fgd1 491616 c.834A>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491620 p.Ile280Val missense_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575764 c.417C>G synonymous_variant 0.39 isoniazid
ethionamide
mshA 575771 p.Val142Thr missense_variant 0.4 isoniazid
ethionamide
mshA 575776 c.429C>T synonymous_variant 0.41 isoniazid
ethionamide
mshA 575782 c.435G>C synonymous_variant 0.41 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.43 isoniazid
ethionamide
mshA 575795 p.Ile150Val missense_variant 0.43 isoniazid
ethionamide
mshA 575800 c.453G>C synonymous_variant 0.4 isoniazid
ethionamide
mshA 575803 c.456C>T synonymous_variant 0.38 isoniazid Not assoc w R - Interim
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.35 isoniazid
ethionamide
mshA 575842 c.495G>C synonymous_variant 0.38 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.35 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.28 isoniazid
ethionamide
mshA 575907 p.Ala187Val missense_variant 0.9 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620337 c.447C>G synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620346 c.456C>G synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620358 c.468C>G synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Ser missense_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.35 kanamycin
capreomycin
amikacin
ccsA 620397 c.507C>G synonymous_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.28 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620421 c.531G>T synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620427 c.537C>G synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620439 c.549T>C synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620442 c.552G>C synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620445 c.555A>G synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620454 c.564C>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620460 c.570T>C synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620619 c.729G>C synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
ccsA 620631 c.741T>C synonymous_variant 0.31 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620652 c.762C>G synonymous_variant 0.43 kanamycin
capreomycin
amikacin
ccsA 620661 c.771C>G synonymous_variant 0.45 kanamycin
capreomycin
amikacin
ccsA 620694 c.804C>G synonymous_variant 0.43 kanamycin
capreomycin
amikacin
ccsA 620698 p.Val270Ile missense_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620715 c.825C>T synonymous_variant 0.42 kanamycin
capreomycin
amikacin
ccsA 620730 c.840C>T synonymous_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.45 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620742 c.852G>C synonymous_variant 0.39 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>C synonymous_variant 0.37 kanamycin
capreomycin
amikacin
ccsA 620764 p.Ala292Ser missense_variant 0.34 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
rpoB 760235 c.429T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.41 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.39 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.42 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.44 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.43 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.39 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.46 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.46 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.52 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.48 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.4 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.33 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.32 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.32 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.32 rifampicin
rpoB 760585 p.Asn260Ser missense_variant 0.41 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.43 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.4 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.4 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.36 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.45 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.47 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.47 rifampicin
rpoB 760755 p.His317Asn missense_variant 0.47 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.47 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.52 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.52 rifampicin
rpoB 760784 c.978G>T synonymous_variant 0.53 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.51 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.51 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.5 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.51 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.4 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 0.35 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.34 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.34 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.34 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.3 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.31 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.29 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 0.5 rifampicin
rpoB 761217 p.Pro471Ser missense_variant 0.56 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761240 c.1434C>T synonymous_variant 0.5 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.53 rifampicin
rpoB 761288 c.1482G>T synonymous_variant 0.5 rifampicin
rpoB 761318 c.1512G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.41 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 0.38 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.31 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.25 rifampicin
rpoB 761366 c.1560C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761367 p.Glu521Gln missense_variant 0.25 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.25 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.31 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.24 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.25 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.25 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.23 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.2 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.25 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.48 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.47 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.44 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.44 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.54 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762308 c.2502G>C synonymous_variant 0.5 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.56 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.5 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.47 rifampicin
rpoB 762350 c.2544C>T synonymous_variant 0.46 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.46 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.39 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.38 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.37 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.35 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.34 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.37 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.33 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.33 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.29 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.27 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.48 rifampicin Uncertain significance
rpoB 762920 c.3114C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.48 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.41 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.44 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.47 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.53 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.5 rifampicin
rpoC 763190 c.-180C>T upstream_gene_variant 0.41 rifampicin
rpoC 763199 c.-171G>C upstream_gene_variant 0.3 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>T synonymous_variant 0.47 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763588 c.219C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.26 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.24 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.26 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.29 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.32 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.31 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.31 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.34 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.31 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.27 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.27 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.33 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.32 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.35 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.32 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.35 rifampicin
rpoC 763882 c.513G>A synonymous_variant 0.36 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.36 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.36 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.33 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.3 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.32 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.32 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.32 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.32 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764059 c.690G>T synonymous_variant 0.43 rifampicin
rpoC 764071 c.702G>C synonymous_variant 0.43 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.29 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.32 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.36 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764195 c.826_828delTCGinsAGC synonymous_variant 0.32 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.29 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.29 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.29 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.3 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.3 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 0.52 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.52 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.52 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.52 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.61 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.64 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.57 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.47 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.47 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.47 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.52 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.5 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.45 rifampicin
rpoC 764512 c.1143G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.59 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.5 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.48 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.46 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.43 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.45 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765445 c.2076G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 0.3 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.34 rifampicin
rpoC 765800 p.Phe811Leu missense_variant 0.39 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.4 rifampicin
rpoC 765814 c.2445A>C synonymous_variant 0.42 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.4 rifampicin
rpoC 765823 c.2454C>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.57 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.55 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.55 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.53 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.52 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766666 c.3297C>G synonymous_variant 0.27 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.29 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 0.27 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.28 rifampicin
rpoC 766694 p.Gln1109Asp missense_variant 0.25 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.23 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.24 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.24 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.24 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.24 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.24 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767105 p.Asn1246Gln missense_variant 0.54 rifampicin Uncertain significance
rpoC 767119 c.3750A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.57 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.57 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.57 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.57 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.54 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775940 c.2541C>T synonymous_variant 0.38 bedaquiline
clofazimine
mmpL5 775951 c.2530C>T synonymous_variant 0.62 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.58 bedaquiline
clofazimine
mmpL5 775994 p.Ile829Leu missense_variant 0.52 bedaquiline
clofazimine
mmpL5 775997 c.2484T>G synonymous_variant 0.55 bedaquiline
clofazimine
mmpL5 776000 p.Leu827Ile missense_variant 0.5 bedaquiline
clofazimine
mmpL5 776030 c.2451G>C synonymous_variant 0.5 bedaquiline
clofazimine
mmpL5 776053 c.2428T>C synonymous_variant 0.4 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Leu missense_variant 1.0 bedaquiline
clofazimine
mmpL5 776182 p.Asp767Asn missense_variant 0.88 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781709 c.150G>C synonymous_variant 0.48 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.45 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.39 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.38 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.4 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.38 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.46 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.44 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.42 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.42 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.42 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.45 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.43 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.43 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.42 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.42 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.44 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.45 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.41 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.44 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.46 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.48 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.45 streptomycin Uncertain significance
rplC 800516 c.-293G>C upstream_gene_variant 0.48 linezolid
rplC 800543 c.-266C>T upstream_gene_variant 0.54 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.56 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.7 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.68 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.69 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.63 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.62 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.62 linezolid
rplC 800603 c.-206G>C upstream_gene_variant 0.65 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.66 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.65 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.66 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.64 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.63 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.62 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 0.54 linezolid
rplC 800684 c.-125G>A upstream_gene_variant 0.56 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.54 linezolid
rplC 800702 c.-107G>A upstream_gene_variant 0.48 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.47 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.38 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.38 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.39 linezolid
rplC 800904 c.96G>C synonymous_variant 0.27 linezolid
rplC 800916 c.108A>G synonymous_variant 0.27 linezolid
rplC 800921 p.Arg38Leu missense_variant 0.25 linezolid
rplC 800928 c.120C>T synonymous_variant 0.25 linezolid
rplC 800931 c.123G>C synonymous_variant 0.25 linezolid
rplC 800937 c.129A>G synonymous_variant 0.25 linezolid
rplC 800946 c.138T>C synonymous_variant 0.24 linezolid
rplC 800949 c.141T>C synonymous_variant 0.24 linezolid
rplC 800964 c.156G>C synonymous_variant 0.26 linezolid
rplC 800985 c.177A>G synonymous_variant 0.19 linezolid
rplC 801195 c.387G>T synonymous_variant 0.34 linezolid
rplC 801205 p.Arg133Ala missense_variant 0.37 linezolid
rplC 801210 c.402T>C synonymous_variant 0.37 linezolid
rplC 801220 p.Ser138Ala missense_variant 0.34 linezolid
rplC 801231 c.423C>T synonymous_variant 0.33 linezolid
rplC 801237 c.429G>A synonymous_variant 0.33 linezolid
rplC 801252 c.444G>C synonymous_variant 0.37 linezolid
rplC 801264 c.456C>T synonymous_variant 0.34 linezolid
rplC 801267 c.459A>C synonymous_variant 0.34 linezolid
rplC 801276 c.468G>C synonymous_variant 0.36 linezolid
rplC 801281 p.Ala158Gly missense_variant 0.31 linezolid
rplC 801285 c.477G>C synonymous_variant 0.32 linezolid
rplC 801307 p.Ala167Ser missense_variant 0.23 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1304580 c.1650T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304671 p.Val581Thr missense_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Asp missense_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>T synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.38 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
atpE 1461132 p.Val30Ile missense_variant 0.36 bedaquiline
atpE 1461137 c.93C>G synonymous_variant 0.4 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.4 bedaquiline
atpE 1461155 c.111C>G synonymous_variant 0.47 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.42 bedaquiline Uncertain significance
atpE 1461167 c.123G>T synonymous_variant 0.41 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.41 bedaquiline
atpE 1461179 c.135G>C synonymous_variant 0.38 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.39 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.41 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.33 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.28 bedaquiline
atpE 1461224 c.180T>G synonymous_variant 0.27 bedaquiline
atpE 1461227 c.183G>A synonymous_variant 0.27 bedaquiline
atpE 1461230 c.186G>C synonymous_variant 0.29 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.29 bedaquiline
atpE 1461251 c.207G>C synonymous_variant 0.22 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.45 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.43 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.48 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473717 n.60G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230delTinsAA non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474417 n.762_765delACGC non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474426 n.769_773delTACGCinsGTA non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474432 n.775C>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474438 n.781delAinsGT non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474439 n.782A>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053T>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474711 n.1054G>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474716 n.1059_1063delAAAGCinsCCAAGAGT non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475618 n.1961C>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475626 n.1969delTinsCC non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.65 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.79 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
inhA 1674006 c.-196T>G upstream_gene_variant 0.33 isoniazid
ethionamide
inhA 1674210 c.9A>C synonymous_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R - Interim
rpsA 1833589 c.48A>C synonymous_variant 0.24 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.24 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.24 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.22 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.22 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.35 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.32 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.4 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.43 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.45 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.44 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.41 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.38 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.36 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.32 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834168 c.627C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834169 p.Thr210Ala missense_variant 0.32 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.46 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.5 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.49 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.49 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.62 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.62 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.66 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.66 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.6 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.59 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.56 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.48 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.48 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 0.53 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.46 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.46 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834663 c.1122C>T synonymous_variant 0.55 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.55 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.55 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.61 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.37 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155696 p.Ala139Val missense_variant 0.19 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.18 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.18 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.19 isoniazid
katG 2155742 p.Gly124Arg missense_variant 0.21 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.21 isoniazid
katG 2155749 c.363C>T synonymous_variant 0.2 isoniazid Not assoc w R - Interim
katG 2155752 c.360C>T synonymous_variant 0.2 isoniazid
katG 2155764 p.His116Glu missense_variant 0.19 isoniazid
katG 2155769 p.Ile115Val missense_variant 0.2 isoniazid
katG 2155770 c.342C>G synonymous_variant 0.2 isoniazid
katG 2155782 c.330C>A synonymous_variant 0.22 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.54 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.5 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.48 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 0.42 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.39 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.19 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.19 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.23 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.2 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.24 isoniazid
kasA 2518726 c.612G>A synonymous_variant 0.29 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.27 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.26 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.24 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.25 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.25 isoniazid
kasA 2518785 p.Glu224Ala missense_variant 0.26 isoniazid
kasA 2518787 p.Arg225Gly missense_variant 0.26 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.27 isoniazid
kasA 2518795 c.681C>T synonymous_variant 0.27 isoniazid
kasA 2518813 c.699C>T synonymous_variant 0.27 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.27 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.31 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.23 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.24 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.23 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.2 isoniazid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625243 c.-333T>G upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625663 c.-753G>A upstream_gene_variant 0.28 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrB 3625711 c.903C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625732 c.882C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3625753 p.Ala287Gln missense_variant 0.4 rifampicin
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625804 c.-896_-894delAGGinsCGC upstream_gene_variant 0.39 rifampicin
bedaquiline
lpqB 3625822 c.-912C>T upstream_gene_variant 0.4 rifampicin
bedaquiline
lpqB 3625828 c.-918G>C upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625840 c.-930A>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3625845 p.Ser257Thr missense_variant 0.24 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625855 c.759G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrA 3626969 c.381C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3626972 c.-359A>G upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrA 3626978 p.Asp124Glu missense_variant 0.36 rifampicin Uncertain significance
bedaquiline
mtrB 3626999 c.-386G>C upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3627002 c.-389G>C upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3627005 c.-392G>A upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrB 3627032 c.-419G>C upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrA 3627041 p.Ile103Val missense_variant 0.47 rifampicin
bedaquiline
mtrB 3627044 c.-431C>T upstream_gene_variant 0.47 rifampicin
bedaquiline
mtrB 3627059 c.-446G>C upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3627062 c.-449G>A upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627071 c.-458G>C upstream_gene_variant 0.41 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627101 c.-488C>G upstream_gene_variant 0.41 rifampicin
bedaquiline
mtrB 3627110 c.-497G>C upstream_gene_variant 0.38 rifampicin
bedaquiline
fbiB 3641625 p.Ala31Thr missense_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
rpoA 3877638 c.870T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.28 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.2 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.21 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.3 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.4 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.4 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.4 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.41 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877770 c.735_738delGTCAinsCAGC synonymous_variant 0.36 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.39 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.53 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.53 rifampicin
rpoA 3877875 c.633T>A synonymous_variant 0.5 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.54 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.56 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.46 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.3 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.3 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.21 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.21 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.28 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.38 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.43 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.41 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.42 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>A synonymous_variant 0.57 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.59 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3878238 c.270C>T synonymous_variant 0.64 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.63 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.63 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.61 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.55 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.4 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
clpC1 4038551 c.2154C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038563 c.2142C>T synonymous_variant 0.25 pyrazinamide
clpC1 4038584 c.2121G>A synonymous_variant 0.38 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.39 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.38 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.43 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.41 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.4 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.38 pyrazinamide
clpC1 4038660 c.2044_2045delTCinsAG synonymous_variant 0.36 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4038679 p.Pro676Ala missense_variant 0.42 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.47 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 0.47 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.45 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.45 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038776 c.1929G>A synonymous_variant 0.44 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.44 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.51 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.47 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.49 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.49 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.49 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.49 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.49 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.49 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.5 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.49 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.46 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039064 c.1641C>T synonymous_variant 0.39 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.41 pyrazinamide
clpC1 4039100 c.1605C>T synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.45 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.45 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.47 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039320 p.Ala462Gly missense_variant 0.45 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.42 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.42 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039361 c.1344C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.49 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.52 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.52 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.35 pyrazinamide
clpC1 4039457 c.1248C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.41 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.42 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.48 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.49 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.49 pyrazinamide
clpC1 4039832 c.873C>A synonymous_variant 0.49 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039883 c.822G>A synonymous_variant 0.54 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.71 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 0.74 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.72 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.72 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.69 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.64 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.54 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.48 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040363 c.342A>T synonymous_variant 0.27 pyrazinamide
clpC1 4040366 c.339C>T synonymous_variant 0.28 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.41 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.41 pyrazinamide
clpC1 4040390 c.315C>G synonymous_variant 0.44 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.38 pyrazinamide
clpC1 4040433 c.271_272delAGinsTC synonymous_variant 0.36 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.38 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.38 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.41 pyrazinamide
clpC1 4040462 c.243C>T synonymous_variant 0.39 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.41 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040495 c.210C>G synonymous_variant 0.48 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.43 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.43 pyrazinamide
glpK 4138583 c.1173G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138625 c.1131G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138628 c.1128T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138634 c.1122G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138646 c.1110G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138822 p.Asn312Asp missense_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240789 c.927T>C synonymous_variant 0.33 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.31 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247491 c.978G>C synonymous_variant 0.42 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.45 ethambutol
embB 4247511 p.Tyr333Phe missense_variant 0.45 ethambutol
embB 4247527 c.1014G>C synonymous_variant 0.52 ethambutol
embB 4247536 c.1023C>A synonymous_variant 0.48 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.29 ethambutol
embB 4248112 c.1599C>G synonymous_variant 0.23 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.23 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.26 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.25 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.24 ethambutol
embB 4248143 p.Leu544Ile missense_variant 0.24 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4248158 p.Cys549Ser missense_variant 0.24 ethambutol
embB 4248167 p.Thr552Ala missense_variant 0.32 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.32 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.32 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.32 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.32 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.35 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embB 4248225 p.Ala571Val missense_variant 0.3 ethambutol Uncertain significance
embB 4248242 p.Val577Ile missense_variant 0.26 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.27 ethambutol
embB 4248256 c.1743C>G synonymous_variant 0.27 ethambutol
embB 4248264 p.Phe584Cys missense_variant 0.3 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R