TB-Profiler result

Run: ERR9787165

Summary

Run ID: ERR9787165

Sample name:

Date: 2024-03-24T19:26:46.795988

Number of reads: 935911

Percentage reads mapped: 73.21

Median coverage: 42.0

Strain: lineage6.1.3

Spoligotype:

Drug-resistance: Other


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage6.1.3 West-Africa 2 RD702 0.42
lineage6 West-Africa 2 RD702 0.93
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Tyr384Asn Mutation from literature
p.Ala388Gly Mutation from literature
p.Asn399Asp Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.412_414delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1078_1080delTTGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491194 c.412_414delCTAinsTG frameshift_variant&stop_gained 0.23 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.23 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304008 c.1078_1080delTTGinsCC frameshift_variant&missense_variant 0.23 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance Mutation from literature
embB 4247663 p.Tyr384Asn missense_variant 0.2 ethambutol Mutation from literature
embB 4247676 p.Ala388Gly missense_variant 0.22 ethambutol Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.22 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 882 c.882C>T synonymous_variant 0.18 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.18 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.21 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.22 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.23 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.23 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.22 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.2 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.2 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.2 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.2 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.2 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.23 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.2 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.2 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.2 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.21 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.21 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.23 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.22 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.23 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.21 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.21 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.23 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.22 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.21 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.24 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.24 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.26 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.28 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.27 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.32 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.34 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.37 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.35 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.35 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.34 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.34 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.34 isoniazid Not assoc w R - Interim
dnaA 1311 c.1311C>G synonymous_variant 0.31 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.31 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.3 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.3 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.32 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.31 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.24 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.25 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.22 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.24 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.24 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.24 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.22 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.2 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.2 isoniazid
gyrB 6238 c.999G>A synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.24 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6446 p.Ala403Ser missense_variant 0.87 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6541 c.1302C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642_1644delTTGinsCC frameshift_variant&missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin
gyrA 6889 c.-413G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6898 c.-404G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7442 c.141G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCC frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.23 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8357 c.1056G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8367 c.1066C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8400 c.1099_1101delGACinsAT frameshift_variant&missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8493 p.Leu398Phe missense_variant 0.59 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8504 c.1203G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8553 c.1252C>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8636 c.1335A>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8708 c.1407G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.39 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9101 c.1800A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9104 c.1803C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9153 p.Thr618Glu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9176 c.1875G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9179 c.1878C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9224 c.1923C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 p.Asp669Glu missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9344 c.2043C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9359 c.2058C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
fgd1 490827 c.45C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490854 c.72C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491067 c.285C>T synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fgd1 491083 p.Val101Ile missense_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491130 c.348C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491184 c.402A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491668 p.Lys296Glu missense_variant 0.73 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575755 c.408G>A synonymous_variant 0.18 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.18 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.17 ethionamide
isoniazid
mshA 575771 p.Val142Phe missense_variant 0.17 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.29 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575875 c.528C>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.2 ethionamide
isoniazid
ccsA 619507 c.-384A>G upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619528 c.-363C>G upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356_-354delCAAinsGCG upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619543 c.-348C>G upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619561 c.-330G>C upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>C upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
Rv0565c 656432 p.Gly347Ser missense_variant 0.89 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.21 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.19 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.19 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.19 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.19 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.18 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.21 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.24 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.28 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.31 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.32 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.32 isoniazid
nusG 734580 c.327T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.19 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.24 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.2 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.2 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.21 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.2 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.2 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.2 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.21 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.21 rifampicin
nusG 734658 c.405A>G synonymous_variant 0.23 rifampicin Not assoc w R
nusG 734661 c.408A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734664 c.411T>G synonymous_variant 0.21 rifampicin
nusG 734673 c.420A>G synonymous_variant 0.21 rifampicin
nusG 734676 c.423G>C synonymous_variant 0.22 rifampicin
nusG 734679 c.426C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734680 c.427_429delGCCinsAG frameshift_variant&missense_variant 0.22 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.21 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.23 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.31 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.3 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.32 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.33 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.35 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.36 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.36 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.48 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.46 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.4 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.34 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.38 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.4 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.34 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.3 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.31 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760855 p.Thr350Ile missense_variant 0.92 rifampicin Uncertain significance
rpoB 760934 c.1128C>T synonymous_variant 0.17 rifampicin
rpoB 760969 p.Ser388Leu missense_variant 0.75 rifampicin Not assoc w R
rpoB 760982 c.1176G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.29 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.32 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.36 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.45 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.43 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.46 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.35 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.34 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.3 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.24 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.22 rifampicin
rpoB 761423 c.1617T>C synonymous_variant 0.19 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.19 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.19 rifampicin
rpoB 761439 p.Asp545Asn missense_variant 0.19 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.2 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.2 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.2 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.2 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.24 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.28 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.32 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.37 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.4 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761639 c.1833G>A synonymous_variant 0.36 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.33 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.31 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.27 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 1.0 rifampicin Not assoc w R
rpoB 761732 c.1926C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.26 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.29 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.29 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.26 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.28 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.27 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.24 rifampicin
rpoB 761815 p.Ala670Asp missense_variant 0.18 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.27 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.25 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.25 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.25 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.25 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.28 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.35 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.33 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.35 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.35 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.35 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.41 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.54 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.53 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.52 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.52 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.54 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.48 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.49 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.49 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.48 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.43 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.4 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.37 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.36 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.34 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.26 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.26 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.27 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.27 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.31 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.36 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.6 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.39 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.42 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.3 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.28 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.28 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.28 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.29 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.2 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.2 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.19 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.17 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.23 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.31 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.44 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.42 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.43 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.41 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.43 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.4 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.37 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.36 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.36 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.36 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.32 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.3 rifampicin
rpoC 763877 c.508_510delCTAinsTG frameshift_variant&stop_gained 0.29 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.33 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.33 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.33 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.36 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.37 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.32 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.31 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.33 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.32 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.3 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.31 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.31 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.33 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.34 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.35 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.39 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.29 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.28 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.29 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.31 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.3 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.31 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.33 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.32 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.28 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.28 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.23 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.25 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.26 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.3 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.29 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.28 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.3 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.31 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.34 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.28 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.28 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.31 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.38 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.29 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.22 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.23 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.24 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.22 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.2 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.2 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.2 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.22 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.38 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.44 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.47 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.47 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.43 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.41 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.33 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.39 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.32 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.32 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.38 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.3 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.3 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.31 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.3 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.48 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.5 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.51 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.49 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.44 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.5 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.48 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.48 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.47 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.49 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.38 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.42 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.39 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.34 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766168 c.2799C>T synonymous_variant 0.32 rifampicin
rpoC 766174 p.Asn935Lys missense_variant 0.3 rifampicin
rpoC 766178 p.Ile937Val missense_variant 0.28 rifampicin
rpoC 766185 p.Glu939Ala missense_variant 0.26 rifampicin
rpoC 766189 c.2820T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766192 c.2823T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766193 c.2824_2826delCAAinsGG frameshift_variant&missense_variant 0.25 rifampicin
rpoC 766204 c.2835C>T synonymous_variant 0.26 rifampicin
rpoC 766207 c.2838T>C synonymous_variant 0.26 rifampicin
rpoC 766216 c.2847T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766219 p.Asp950Glu missense_variant 0.24 rifampicin
rpoC 766222 c.2853T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766226 c.2857T>C synonymous_variant 0.23 rifampicin
rpoC 766231 c.2862T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766234 c.2865T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766237 c.2868T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766240 c.2871T>C synonymous_variant 0.23 rifampicin
rpoC 766243 c.2874C>G synonymous_variant 0.24 rifampicin
rpoC 766258 c.2889T>C synonymous_variant 0.28 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.26 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.26 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.27 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.25 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.24 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.29 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.28 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.26 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.26 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.33 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.33 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.35 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.35 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.35 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.35 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.34 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.4 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.4 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.42 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.38 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.38 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.38 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.35 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.37 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.36 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.37 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.34 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.34 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.23 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.25 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.28 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.3 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.42 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.53 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.52 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.45 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.48 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.5 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.5 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.46 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.34 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.29 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.29 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767265 p.Ala1299Glu missense_variant 0.19 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>T synonymous_variant 0.18 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpS5 779511 c.-606T>C upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.22 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.24 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.24 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.29 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.26 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.27 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.26 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.26 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.26 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.27 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.3 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.28 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.27 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.27 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.28 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.29 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.26 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.27 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.25 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.3 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.28 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.32 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.28 streptomycin Uncertain significance
rplC 800232 c.-577G>T upstream_gene_variant 1.0 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.18 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.2 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.21 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.21 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.19 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.2 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.2 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.2 linezolid
rplC 800817 c.9A>T synonymous_variant 0.18 linezolid
rplC 800844 c.36T>C synonymous_variant 0.21 linezolid
rplC 801195 c.387G>C synonymous_variant 0.19 linezolid
rplC 801207 c.399C>T synonymous_variant 0.19 linezolid
rplC 801246 c.438C>T synonymous_variant 0.21 linezolid
rplC 801249 c.441T>C synonymous_variant 0.21 linezolid
rplC 801255 c.447C>T synonymous_variant 0.21 linezolid
rplC 801264 c.456C>T synonymous_variant 0.18 linezolid
rplC 801267 c.459A>T synonymous_variant 0.19 linezolid
rplC 801270 c.462T>C synonymous_variant 0.19 linezolid
rplC 801276 c.468G>C synonymous_variant 0.19 linezolid
rplC 801309 c.501C>G synonymous_variant 0.22 linezolid
rplC 801312 c.504G>C synonymous_variant 0.2 linezolid
rplC 801321 c.513C>T synonymous_variant 0.25 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.26 linezolid
rplC 801339 c.531T>C synonymous_variant 0.29 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.29 linezolid
rplC 801348 c.540T>G synonymous_variant 0.33 linezolid
rplC 801357 c.549T>C synonymous_variant 0.3 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.33 linezolid
rplC 801402 c.594T>C synonymous_variant 0.38 linezolid
rplC 801405 c.597T>C synonymous_variant 0.39 linezolid
rplC 801423 c.615G>C synonymous_variant 0.35 linezolid
rplC 801426 c.618C>G synonymous_variant 0.35 linezolid
rplC 801427 p.Met207Val missense_variant 0.37 linezolid
rplC 801438 c.630T>C synonymous_variant 0.39 linezolid
rplC 801442 p.Ile212Val missense_variant 0.39 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303480 p.Gln184Glu missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303489 c.559C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303501 c.571C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303521 c.591C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303530 c.600G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303654 c.724C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303663 c.733C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303671 c.741C>T synonymous_variant 0.34 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303827 c.897A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303866 p.Glu312Asp missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303977 c.1047C>A synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304050 c.1120T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Ile missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.32 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.44 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
Rv1258c 1406685 p.Val219Ala missense_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
embR 1416633 p.Leu239Val missense_variant 1.0 ethambutol Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
atpE 1461251 c.207G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.2 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.36 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.4 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
inhA 1673667 c.-535A>G upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673679 c.-523T>C upstream_gene_variant 0.22 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673685 c.-517C>T upstream_gene_variant 0.26 ethionamide
isoniazid
fabG1 1673710 p.Leu91Ile missense_variant 0.28 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.3 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.32 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.28 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.28 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.28 ethionamide
isoniazid
inhA 1673778 c.-424C>G upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673890 p.Ala151Ser missense_variant 0.24 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 0.24 ethionamide
isoniazid
inhA 1673916 c.-286A>C upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.23 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.33 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.26 ethionamide
isoniazid
fabG1 1674049 c.610_612delCAAinsGC frameshift_variant&missense_variant 0.23 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1674063 c.-139G>C upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.2 ethionamide
isoniazid
inhA 1674434 p.Val78Ala missense_variant 0.92 ethionamide Uncertain significance
isoniazid Not assoc w R
rpsA 1833841 c.300C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.36 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.33 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.28 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.23 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.21 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.19 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.23 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.23 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2063121 c.1608A>T synonymous_variant 1.0 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ndh 2101783 c.1260T>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2101804 c.1239T>G synonymous_variant 0.33 ethionamide
delamanid
isoniazid
ndh 2101808 p.Thr412Ser missense_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2101830 p.Ile405Val missense_variant 0.44 ethionamide
delamanid
isoniazid
ndh 2101837 p.Ala402Val missense_variant 0.44 ethionamide Uncertain significance
delamanid
isoniazid Uncertain significance
ndh 2101872 p.Ile391Phe missense_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2101873 c.1168_1170delTTTinsCA frameshift_variant&missense_variant 0.41 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2101885 c.1158G>A synonymous_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2101888 c.1155T>C synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2101894 c.1149T>G synonymous_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2101912 c.1131G>C synonymous_variant 0.42 ethionamide
delamanid
isoniazid
ndh 2101920 c.1123A>C synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2101924 c.1119T>G synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2101939 c.1104A>G synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.36 ethionamide
delamanid
isoniazid
ndh 2101963 c.1080G>A synonymous_variant 0.34 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101966 c.1077T>G synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2101988 p.Ala352Asp missense_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2101990 c.1053G>C synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2101993 c.1050A>G synonymous_variant 0.25 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.23 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.35 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.38 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.24 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.33 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.36 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.31 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.31 isoniazid
kasA 2518951 c.837G>C synonymous_variant 0.33 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.31 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.29 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.29 isoniazid
kasA 2518975 c.861C>G synonymous_variant 0.32 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.32 isoniazid
kasA 2518999 c.885G>C synonymous_variant 0.32 isoniazid
kasA 2519008 c.894C>G synonymous_variant 0.3 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.2 isoniazid
ahpC 2726357 c.165A>G synonymous_variant 0.25 isoniazid Not assoc w R - Interim
ahpC 2726366 c.174G>C synonymous_variant 0.24 isoniazid
ahpC 2726387 c.195C>T synonymous_variant 0.2 isoniazid
ahpC 2726397 p.Ser69Gly missense_variant 0.22 isoniazid
ahpC 2726408 c.216T>C synonymous_variant 0.23 isoniazid
ahpC 2726414 c.222G>A synonymous_variant 0.23 isoniazid
ahpC 2726419 p.Glu76Ala missense_variant 0.23 isoniazid
ahpC 2726432 c.240C>G synonymous_variant 0.21 isoniazid
ahpC 2726436 c.244_246delATCinsGT frameshift_variant&missense_variant 0.21 isoniazid Uncertain significance
ahpC 2726444 c.252G>T synonymous_variant 0.22 isoniazid Not assoc w R - Interim
ahpC 2726447 c.255T>G synonymous_variant 0.22 isoniazid
ahpC 2726453 c.261T>C synonymous_variant 0.22 isoniazid
ahpC 2726467 p.Ala92Val missense_variant 0.18 isoniazid
ahpC 2726486 c.294A>G synonymous_variant 0.2 isoniazid
ahpC 2726493 c.301_303delAACinsGG frameshift_variant&missense_variant 0.21 isoniazid Uncertain significance
ahpC 2726506 p.Thr105Lys missense_variant 0.23 isoniazid Uncertain significance
ahpC 2726508 c.316_318delTTAinsCG frameshift_variant&missense_variant 0.24 isoniazid Uncertain significance
ahpC 2726528 c.336C>G synonymous_variant 0.25 isoniazid
ahpC 2726551 p.Gln120Leu missense_variant 0.18 isoniazid
ahpC 2726556 p.Ala122Thr missense_variant 0.18 isoniazid Uncertain significance
ahpC 2726579 c.387T>G synonymous_variant 1.0 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.21 isoniazid
ahpC 2726717 c.525A>G synonymous_variant 0.2 isoniazid
Rv2477c 2782537 c.1506T>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782684 c.1359T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782705 c.1338G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782711 c.1332C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782714 c.1329A>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782720 c.1323T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782729 c.1314A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782732 c.1311A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782741 c.1302G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782750 c.1293T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782759 c.1284A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782777 c.1266A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782786 c.1257A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782792 c.1251A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782795 c.1248T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782801 p.Gln414Val missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782807 c.1234_1236delTATinsCC frameshift_variant&missense_variant 0.3 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782816 c.1227T>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782822 c.1221G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782828 c.1215T>C synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782841 p.Thr401Asn missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782847 p.Arg399Lys missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782852 c.1191T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.42 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.43 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.47 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>T synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.41 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783662 c.381G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3064860 c.1332G>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064863 c.1329G>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064872 c.1320T>G synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064877 p.Ser439Ala missense_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064881 p.Ser437Ala missense_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064887 c.1305A>G synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064893 c.1299C>G synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064896 c.1296T>C synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064914 c.1278T>G synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064926 c.1264_1266delTTGinsCC frameshift_variant&missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064932 c.1260T>C synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064935 c.1257A>G synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064941 c.1249_1251delCAAinsGG frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064947 c.1245A>G synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064956 c.1234_1236delAGTinsCC frameshift_variant&missense_variant 0.32 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064962 c.1230C>G synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064973 p.Ala407Ser missense_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064974 c.1218T>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064995 c.1197C>G synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064998 c.1194A>G synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065007 c.1185G>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065013 c.1179G>C synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065018 p.Asn392His missense_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065022 c.1170G>C synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065028 c.1162_1164delGTGinsAC frameshift_variant&missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065040 c.1152C>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065052 c.1140G>A synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065055 c.1137T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065073 c.1119C>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065079 c.1113T>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065082 c.1110G>T synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065085 c.1105_1107delAGGinsCC frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065088 c.1104A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065109 c.1081_1083delAGAinsCC frameshift_variant&missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065115 c.1077C>A synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065126 p.Ser356Ala missense_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065127 c.1065G>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065130 p.Ala354Glu missense_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065133 c.1059T>C synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065142 c.1050A>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065151 c.1041G>C synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065183 p.Ser337Ala missense_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065186 c.1006T>C synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065190 c.1000_1002delATCinsGG frameshift_variant&missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065196 c.996T>C synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065202 c.990T>G synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065205 c.987T>C synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065210 c.982T>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065223 c.969T>C synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065229 c.963G>C synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065232 c.960T>C synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065241 c.951A>G synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065262 c.930G>A synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065268 c.924A>G synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065295 c.897A>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065298 p.Asp298Glu missense_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065306 p.Ala296Pro missense_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065311 p.Thr294Met missense_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065323 p.Ala290Gly missense_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066432 c.-241T>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066435 c.-246_-244delGGTinsAAC upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066452 c.-261T>A upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066453 c.-262G>A upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066456 c.-265A>G upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066462 c.-271G>A upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066465 c.-276_-274delGGGinsAAT upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066471 c.-280A>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066476 c.-285C>G upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066482 c.-291G>T upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066483 c.-292T>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066810 c.-619G>A upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066855 c.-664T>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066864 c.-673C>G upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066867 c.-676T>C upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066876 c.-685T>C upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066879 c.-688T>C upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066891 c.-700G>C upstream_gene_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066900 c.-709A>G upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066905 c.-714T>C upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066906 c.-715C>G upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066910 c.-719C>T upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066912 c.-721G>C upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066924 c.-735_-733delATCinsCGA upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066927 c.-736A>G upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066933 c.-743_-742delGGinsAC upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066960 c.-769C>G upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066969 c.-778G>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066981 c.-790T>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066987 c.-796C>T upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3067001 c.-810G>A upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3067018 c.-827G>A upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067295 c.651C>T synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067388 c.558C>G synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.45 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.5 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.48 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.54 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.52 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.44 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.4 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.39 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.42 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.38 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.4 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.44 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067661