TB-Profiler result

Run: SRR3675572
Summary

Run ID: SRR3675572

Sample name:

Date: 2024-10-04T06:00:01.484007

Number of reads: 654322

Percentage reads mapped: 45.69

Median coverage: 18.0

Strain:

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.2.BCG M.bovis None 0.09
lineage6.2.3 West-Africa 2 RD702 0.06
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Leu359Ile Uncertain significance Mutation from literature
p.Ala659Thr Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.54 ethambutol Mutation from literature
embB 4247588 p.Leu359Ile missense_variant 0.62 ethambutol Uncertain significance Mutation from literature
embB 4248488 p.Ala659Thr missense_variant 0.25 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 30 c.30C>G synonymous_variant 0.63 isoniazid
dnaA 588 c.588A>C synonymous_variant 0.41 isoniazid
dnaA 597 c.597C>G synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 600 c.600T>A synonymous_variant 0.39 isoniazid
dnaA 612 c.612G>C synonymous_variant 0.47 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.45 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 649 c.649C>T synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.41 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.32 isoniazid
dnaA 669 c.669C>T synonymous_variant 0.29 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.35 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.42 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.4 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.43 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.55 isoniazid Not assoc w R - Interim
dnaA 768 c.768C>G synonymous_variant 0.5 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.5 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.44 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.41 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.44 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.44 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.44 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.38 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.45 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.47 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.47 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.47 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.55 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.62 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.52 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.48 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.48 isoniazid
dnaA 1003 c.1003C>T synonymous_variant 0.47 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.47 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.47 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.53 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.52 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.52 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.5 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.56 isoniazid
dnaA 1218 c.1218C>G synonymous_variant 0.31 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.33 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.42 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.47 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.49 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.49 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.49 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.47 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.44 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.44 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.47 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.47 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.47 isoniazid Not assoc w R - Interim
dnaA 1311 c.1311C>G synonymous_variant 0.48 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.5 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.5 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.5 isoniazid
dnaA 1323 c.1323C>T synonymous_variant 0.52 isoniazid Not assoc w R - Interim
dnaA 1332 c.1332A>C synonymous_variant 0.59 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.61 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.6 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.58 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.56 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.57 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.53 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.53 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.53 isoniazid
gyrB 5671 c.432C>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 5782 c.543A>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrB 5788 c.549G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrB 5791 c.552A>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrB 5803 c.564A>G synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrB 5806 c.567C>G synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrB 5809 c.570C>G synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrB 5824 c.585A>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrB 5827 c.588G>A synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrB 5849 c.610C>T synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrB 5854 c.615C>A synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrB 5863 c.624G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrB 5873 c.634A>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrB 5880 p.Thr214Ser missense_variant 0.35 levofloxacin
moxifloxacin
gyrB 5882 p.Gln215Asn missense_variant 0.35 levofloxacin
moxifloxacin
gyrB 5887 p.Asp216Glu missense_variant 0.35 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.55 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6446 p.Ala403Ser missense_variant 0.92 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6598 c.-704C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.43 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.48 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7475 c.174A>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7664 c.363T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCGC synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7697 c.396C>A synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCTC synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7725 c.424C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGT synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7823 c.522G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8096 c.795T>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.6 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.58 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.78 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTTG synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>T synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8367 c.1066C>T synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.74 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.74 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8400 p.Asp367Asn missense_variant 0.61 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8708 c.1407G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 8762 c.1461G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.48 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8816 c.1515C>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.51 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>A synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.54 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9153 p.Thr618Glu missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9656 c.2355C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9665 c.2364A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9666 p.Arg789Gly missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9674 c.2373T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
Rv0010c 13438 p.Gly41Arg missense_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491043 c.261T>G synonymous_variant 0.69 pretomanid
delamanid
clofazimine
fgd1 491049 c.267T>C synonymous_variant 0.69 pretomanid
delamanid
clofazimine
fgd1 491063 p.Gly94Ala missense_variant 0.67 pretomanid
delamanid
clofazimine
fgd1 491077 p.Asn99Asp missense_variant 0.53 pretomanid
delamanid
clofazimine
fgd1 491082 c.300T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491083 p.Val101Ile missense_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491091 c.309T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491094 c.312C>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fgd1 491097 c.315G>C synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fgd1 491100 c.318C>T synonymous_variant 0.53 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491106 c.324T>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fgd1 491121 c.339A>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fgd1 491130 c.348C>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fgd1 491144 p.Ala121Asp missense_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491173 c.391C>A synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491181 c.399T>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491184 c.402A>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491191 p.Gly137Arg missense_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491194 c.412_414delCTAinsTTG synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491202 c.420G>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 491203 p.Gln141Glu missense_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Arg missense_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491244 c.462T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575734 c.387T>G synonymous_variant 0.23 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.25 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.27 isoniazid
ethionamide
mshA 575752 c.405G>C synonymous_variant 0.26 isoniazid
ethionamide
mshA 575755 c.408G>A synonymous_variant 0.26 isoniazid
ethionamide
mshA 575756 c.409C>T synonymous_variant 0.27 isoniazid
ethionamide
mshA 575770 c.423G>A synonymous_variant 0.24 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.24 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.27 isoniazid
ethionamide
mshA 575782 c.435G>C synonymous_variant 0.26 isoniazid
ethionamide
mshA 575809 c.462C>T synonymous_variant 0.26 isoniazid
ethionamide
mshA 575812 c.465C>T synonymous_variant 0.26 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.29 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.3 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.31 isoniazid
ethionamide
mshA 575833 c.486C>G synonymous_variant 0.35 isoniazid
ethionamide
mshA 575845 c.498C>T synonymous_variant 0.37 isoniazid Not assoc w R - Interim
ethionamide
ccsA 620310 c.420C>T synonymous_variant 0.48 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620346 c.456C>G synonymous_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.52 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.52 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.54 kanamycin
capreomycin
amikacin
ccsA 620376 c.486G>C synonymous_variant 0.52 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620389 c.499C>T synonymous_variant 0.48 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.46 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.46 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.46 kanamycin
capreomycin
amikacin
ccsA 620424 c.534G>C synonymous_variant 0.46 kanamycin
capreomycin
amikacin
ccsA 620433 c.543C>G synonymous_variant 0.4 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.31 kanamycin
capreomycin
amikacin
ccsA 620439 c.549T>C synonymous_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620445 c.555A>G synonymous_variant 0.33 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620659 c.769_771delCGCinsAGG synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620664 c.774C>T synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620682 c.792G>A synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.32 kanamycin
capreomycin
amikacin
Rv0565c 656219 p.His418Tyr missense_variant 0.62 ethionamide
Rv0565c 656220 c.1251A>C synonymous_variant 0.62 ethionamide
Rv0565c 656223 c.1248T>C synonymous_variant 0.62 ethionamide Not assoc w R - Interim
Rv0565c 656226 p.Ala415Ser missense_variant 0.62 ethionamide
Rv0565c 656238 p.Ala411Glu missense_variant 0.62 ethionamide
Rv0565c 656243 p.Leu410Met missense_variant 0.62 ethionamide
Rv0565c 656244 c.1227A>C synonymous_variant 0.62 ethionamide
Rv0565c 656265 c.1206G>C synonymous_variant 0.62 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.62 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.62 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.67 ethionamide
Rv0565c 656298 c.1173G>C synonymous_variant 0.69 ethionamide
Rv0565c 656304 c.1167T>C synonymous_variant 0.69 ethionamide
Rv0565c 656391 c.1080C>G synonymous_variant 0.33 ethionamide
Rv0565c 656402 p.Ala357Thr missense_variant 0.33 ethionamide
Rv0565c 656412 c.1059T>G synonymous_variant 0.35 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.35 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.35 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.32 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.32 ethionamide
Rv0565c 657348 c.123A>G synonymous_variant 0.32 ethionamide
Rv0565c 657356 p.Ile39Val missense_variant 0.32 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.42 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.41 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.48 isoniazid
hadA 731687 c.-243_-242insCACAGATCTTTT upstream_gene_variant 0.5 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.5 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.5 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.5 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.5 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.53 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.52 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.6 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.62 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.42 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.48 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.5 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.57 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.64 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.64 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.74 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.81 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.85 isoniazid
nusG 734370 c.117A>G synonymous_variant 0.37 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.43 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.44 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.5 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.46 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.48 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.48 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.48 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.43 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.39 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.39 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.42 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.38 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.36 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.42 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.35 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.53 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.54 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.53 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.68 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.68 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.65 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.63 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.59 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.59 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.58 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.59 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.59 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.61 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.73 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.74 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.79 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.74 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.69 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.81 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.79 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.63 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.68 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.66 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.69 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.52 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.53 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.5 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.43 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.38 rifampicin
rpoB 761373 p.Val523His missense_variant 0.31 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.38 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761492 c.1686G>C synonymous_variant 0.43 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.47 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761559 p.Thr585Ala missense_variant 0.35 rifampicin Uncertain significance
rpoB 761570 c.1764T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.61 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.59 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.44 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.5 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.43 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.43 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.43 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.44 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.46 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.48 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.5 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.48 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.47 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.43 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.38 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.38 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.4 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.38 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.37 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.36 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.39 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.37 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.42 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.43 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.42 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.62 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.76 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.77 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.81 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.82 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.71 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.7 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.64 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.62 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.62 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.72 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.71 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.67 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.69 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.62 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.67 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.7 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.7 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.61 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.62 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.52 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.55 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.55 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.52 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.5 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.48 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.48 rifampicin
rpoB 762926 c.3120C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.76 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.76 rifampicin
rpoC 763025 c.-345C>T upstream_gene_variant 0.75 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.54 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.58 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.53 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.5 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.58 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.7 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.81 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.79 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.67 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.67 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.66 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.65 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.62 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.62 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.54 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.44 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.48 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.48 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.42 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.44 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.48 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.48 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.58 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.56 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.61 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.6 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.56 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.53 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.47 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.58 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.52 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.6 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.44 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.44 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.46 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.55 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.54 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.67 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.73 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.76 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.72 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.72 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.74 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.49 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.43 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.59 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.64 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.57 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.52 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.57 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.35 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.39 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.53 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.51 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.71 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.71 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.68 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.7 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.69 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.66 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.6 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.59 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.59 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.59 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.63 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.59 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.62 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.65 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.62 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.59 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.58 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.6 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.6 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.64 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.63 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.63 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.6 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.61 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.59 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.52 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.38 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.29 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766174 p.Asn935Lys missense_variant 0.31 rifampicin
rpoC 766178 p.Ile937Val missense_variant 0.31 rifampicin
rpoC 766258 c.2889T>C synonymous_variant 0.33 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.25 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.26 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.3 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.31 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.31 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.32 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.31 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.31 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.32 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.33 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.33 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.36 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.39 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.39 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.5 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.5 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.48 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.48 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.41 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.41 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.39 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.55 rifampicin
rpoC 766549 c.3180G>T synonymous_variant 0.47 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.41 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.38 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.35 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.35 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.49 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.48 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.55 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.62 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.63 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.72 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.73 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.73 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.7 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.74 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.58 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.59 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.55 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.54 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.59 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.59 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.64 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.26 rifampicin
mmpL5 775975 c.2506T>C synonymous_variant 0.38 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.35 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781700 c.141G>C synonymous_variant 0.67 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.64 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.64 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.65 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.64 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.62 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.65 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.61 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.61 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.57 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.53 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.52 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.53 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.5 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.51 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.53 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.53 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.55 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.58 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.62 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.62 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.65 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.61 streptomycin Uncertain significance
rplC 800546 c.-263T>G upstream_gene_variant 0.46 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.4 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.39 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.46 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.48 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.52 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.55 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.51 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.48 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.58 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.58 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.6 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.58 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.53 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.53 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.4 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.41 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.43 linezolid
rplC 800814 c.6A>G synonymous_variant 0.42 linezolid
rplC 800817 c.9A>T synonymous_variant 0.4 linezolid
rplC 800844 c.36T>C synonymous_variant 0.41 linezolid
rplC 800865 c.57A>G synonymous_variant 0.42 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.42 linezolid
rplC 800874 c.66A>G synonymous_variant 0.38 linezolid
rplC 800875 p.Val23Ile missense_variant 0.38 linezolid
rplC 800880 c.72A>G synonymous_variant 0.4 linezolid
rplC 800889 c.81C>G synonymous_variant 0.4 linezolid
rplC 800892 c.84G>C synonymous_variant 0.38 linezolid
rplC 800907 c.99C>G synonymous_variant 0.45 linezolid
rplC 800916 c.108A>G synonymous_variant 0.47 linezolid
rplC 800934 c.126C>G synonymous_variant 0.44 linezolid
rplC 800937 c.129A>G synonymous_variant 0.44 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.44 linezolid
rplC 800946 c.138T>C synonymous_variant 0.39 linezolid
rplC 800949 c.141T>C synonymous_variant 0.41 linezolid
rplC 801246 c.438C>T synonymous_variant 0.47 linezolid
rplC 801285 c.477G>C synonymous_variant 0.47 linezolid
rplC 801300 c.492C>G synonymous_variant 0.62 linezolid
rplC 801309 c.501C>G synonymous_variant 0.6 linezolid
rplC 801312 c.504G>C synonymous_variant 0.41 linezolid
rplC 801321 c.513C>T synonymous_variant 0.5 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.5 linezolid
rplC 801339 c.531T>C synonymous_variant 0.43 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.43 linezolid
rplC 801348 c.540T>G synonymous_variant 0.46 linezolid
rplC 801357 c.549T>C synonymous_variant 0.46 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.52 linezolid
rplC 801402 c.594T>C synonymous_variant 0.44 linezolid
rplC 801405 c.597T>C synonymous_variant 0.46 linezolid
rplC 801423 c.615G>C synonymous_variant 0.48 linezolid
rplC 801426 c.618C>G synonymous_variant 0.48 linezolid
rplC 801427 p.Met207Val missense_variant 0.48 linezolid
rplC 801438 c.630T>C synonymous_variant 0.52 linezolid
rplC 801442 p.Ile212Val missense_variant 0.52 linezolid
Rv1129c 1253655 p.Arg294Cys missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
fbiC 1303575 c.645G>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303590 c.660A>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303602 c.672A>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303605 c.675C>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303608 c.678G>A synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>T synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303617 c.687C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303641 c.711C>T synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303650 c.720G>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1303654 c.724C>T synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303671 c.741C>T synonymous_variant 0.43 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1303674 c.744C>G synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1303681 c.751T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303686 c.756C>G synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.54 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303797 c.867A>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>T synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1303944 c.1014G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303953 p.Asp341Glu missense_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303956 c.1026A>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303961 p.Arg344Leu missense_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303971 c.1041T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303980 c.1050G>A synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304097 c.1167G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304106 c.1176G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304127 c.1197A>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304132 p.Ala401Gly missense_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304142 c.1212G>C synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fbiC 1304169 c.1239T>C synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304174 p.Val415Ala missense_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304184 c.1254G>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304187 c.1257T>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304553 c.1623C>T synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.36 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304739 c.1809C>T synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.59 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.59 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.67 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.7 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.73 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.93 pretomanid
delamanid
clofazimine
fbiC 1304862 c.1932G>A synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.6 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.6 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.54 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.64 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473417 n.-241C>T upstream_gene_variant 0.33 capreomycin
linezolid
rrl 1473419 n.-239T>C upstream_gene_variant 0.33 capreomycin
linezolid
rrl 1473420 n.-238A>G upstream_gene_variant 0.32 capreomycin
linezolid
rrl 1473421 n.-237G>A upstream_gene_variant 0.32 capreomycin
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.78 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.65 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673523 c.-679G>T upstream_gene_variant 0.53 isoniazid
ethionamide
inhA 1673535 c.-667A>G upstream_gene_variant 0.5 isoniazid
ethionamide
inhA 1673547 c.-655T>C upstream_gene_variant 0.5 isoniazid
ethionamide
inhA 1673568 c.-634C>G upstream_gene_variant 0.47 isoniazid
ethionamide
inhA 1673574 c.-628C>G upstream_gene_variant 0.47 isoniazid
ethionamide
inhA 1673633 c.-569G>A upstream_gene_variant 0.61 isoniazid
ethionamide
inhA 1673637 c.-565C>G upstream_gene_variant 0.59 isoniazid
ethionamide
inhA 1673641 c.-561G>A upstream_gene_variant 0.57 isoniazid
ethionamide
inhA 1673657 c.-545C>A upstream_gene_variant 0.59 isoniazid
ethionamide
inhA 1673660 c.-542C>A upstream_gene_variant 0.54 isoniazid
ethionamide
inhA 1673664 c.-538A>C upstream_gene_variant 0.56 isoniazid
ethionamide
inhA 1673667 c.-535A>G upstream_gene_variant 0.58 isoniazid
ethionamide
inhA 1673679 c.-523T>C upstream_gene_variant 0.59 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1673685 c.-517C>T upstream_gene_variant 0.68 isoniazid
ethionamide
inhA 1673710 c.-492C>A upstream_gene_variant 0.65 isoniazid
ethionamide
inhA 1673716 c.-486_-485delGCinsAA upstream_gene_variant 0.65 isoniazid
ethionamide
inhA 1673733 c.-469G>C upstream_gene_variant 0.58 isoniazid
ethionamide
inhA 1673748 c.-454A>G upstream_gene_variant 0.58 isoniazid
ethionamide
inhA 1673749 c.-453_-452delAAinsCG upstream_gene_variant 0.57 isoniazid
ethionamide
inhA 1673758 c.-444A>G upstream_gene_variant 0.57 isoniazid
ethionamide
inhA 1673890 c.-312G>T upstream_gene_variant 0.43 isoniazid
ethionamide
inhA 1673901 c.-301A>G upstream_gene_variant 0.5 isoniazid
ethionamide
inhA 1673905 c.-297T>G upstream_gene_variant 0.48 isoniazid
ethionamide
inhA 1673916 c.-286A>C upstream_gene_variant 0.48 isoniazid
ethionamide
inhA 1673917 c.-285G>C upstream_gene_variant 0.48 isoniazid
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.48 isoniazid
ethionamide
inhA 1673941 c.-261G>T upstream_gene_variant 0.48 isoniazid
ethionamide
inhA 1673955 c.-247G>C upstream_gene_variant 0.48 isoniazid
ethionamide
inhA 1673961 c.-241A>C upstream_gene_variant 0.48 isoniazid
ethionamide
inhA 1673985 c.-217C>G upstream_gene_variant 0.52 isoniazid
ethionamide
inhA 1674006 c.-196T>G upstream_gene_variant 0.5 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.4 isoniazid
ethionamide
inhA 1674601 p.Leu134Thr missense_variant 0.4 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.39 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.35 isoniazid
ethionamide
inhA 1674672 c.471C>G synonymous_variant 0.35 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.39 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.4 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.43 isoniazid
ethionamide
inhA 1674738 c.537C>G synonymous_variant 0.39 isoniazid
ethionamide
rpsA 1833554 p.Thr5Ala missense_variant 0.45 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.48 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.48 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.6 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.68 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.73 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.71 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.73 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.71 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.7 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.7 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.78 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.79 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.8 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.8 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.77 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.77 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.76 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.72 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.74 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.73 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.71 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.74 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.73 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.64 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.54 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.29 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.3 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.74 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.74 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.68 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.66 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.58 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.5 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.56 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.59 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.58 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.58 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.62 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.6 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.58 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.55 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.5 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.5 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.56 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.57 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.62 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.53 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.53 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.53 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.53 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.57 linezolid
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064972 c.-244T>C upstream_gene_variant 0.5 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.5 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.5 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.53 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.55 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101804 c.1239T>G synonymous_variant 0.38 isoniazid
delamanid
ethionamide
ndh 2101808 p.Thr412Ser missense_variant 0.43 isoniazid
delamanid
ethionamide
ndh 2101830 p.Ile405Val missense_variant 0.48 isoniazid
delamanid
ethionamide
ndh 2101837 p.Ala402Val missense_variant 0.5 isoniazid Uncertain significance
delamanid
ethionamide Uncertain significance
ndh 2101858 p.LeuIle394PheAla missense_variant 0.58 isoniazid
delamanid
ethionamide
ndh 2101872 p.Ile391Phe missense_variant 0.55 isoniazid
delamanid
ethionamide
ndh 2101873 p.Phe390Leu missense_variant 0.55 isoniazid
delamanid
ethionamide
ndh 2101885 c.1158G>A synonymous_variant 0.6 isoniazid
delamanid
ethionamide
ndh 2101888 c.1155T>C synonymous_variant 0.65 isoniazid
delamanid
ethionamide
ndh 2101894 c.1149T>G synonymous_variant 0.67 isoniazid
delamanid
ethionamide
ndh 2101912 c.1131G>C synonymous_variant 0.77 isoniazid
delamanid
ethionamide
ndh 2101920 c.1123A>C synonymous_variant 0.63 isoniazid
delamanid
ethionamide
ndh 2101924 c.1119T>G synonymous_variant 0.65 isoniazid
delamanid
ethionamide
ndh 2101939 c.1104A>G synonymous_variant 0.6 isoniazid
delamanid
ethionamide
ndh 2101960 c.1083A>G synonymous_variant 0.54 isoniazid
delamanid
ethionamide
ndh 2101963 c.1080G>A synonymous_variant 0.5 isoniazid Not assoc w R - Interim
delamanid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
ndh 2101966 c.1077T>G synonymous_variant 0.5 isoniazid
delamanid
ethionamide
ndh 2101972 c.1071G>C synonymous_variant 0.52 isoniazid
delamanid
ethionamide
ndh 2101988 p.Ala352Asp missense_variant 0.44 isoniazid
delamanid
ethionamide
ndh 2101990 c.1053G>C synonymous_variant 0.44 isoniazid
delamanid
ethionamide
ndh 2101993 c.1050A>G synonymous_variant 0.44 isoniazid
delamanid
ethionamide
ndh 2102014 c.1029C>G synonymous_variant 0.38 isoniazid
delamanid
ethionamide
ndh 2102020 c.1023A>G synonymous_variant 0.35 isoniazid
delamanid
ethionamide
ndh 2102023 c.1020G>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
delamanid
ethionamide
ndh 2102026 c.1017G>C synonymous_variant 0.33 isoniazid
delamanid
ethionamide
katG 2155716 c.396T>G synonymous_variant 0.67 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.62 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.62 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.55 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.55 isoniazid
katG 2156056 p.Gly19Val missense_variant 1.0 isoniazid Uncertain significance
PPE35 2168460 p.Asn718Ser missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517950 c.-165C>G upstream_gene_variant 0.69 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.55 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.52 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518462 c.348A>C synonymous_variant 0.33 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.43 isoniazid
kasA 2518474 c.360G>A synonymous_variant 0.46 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.5 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.5 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.52 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.52 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.45 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.47 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.42 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.38 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.35 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.35 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.35 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.33 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.4 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.4 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.43 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.47 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.5 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.53 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.47 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.38 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.35 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.35 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.35 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.27 isoniazid
kasA 2519108 p.Asp332Gln missense_variant 0.27 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.29 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.27 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.3 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.33 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.33 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.37 isoniazid
ahpC 2726232 p.Gln14Glu missense_variant 0.36 isoniazid
ahpC 2726243 c.51T>G synonymous_variant 0.42 isoniazid
ahpC 2726244 c.52_54delCTCinsTTG synonymous_variant 0.42 isoniazid
ahpC 2726251 p.Gly20Ala missense_variant 0.4 isoniazid Uncertain significance
ahpC 2726255 c.63T>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
ahpC 2726258 c.66C>T synonymous_variant 0.4 isoniazid Not assoc w R - Interim
ahpC 2726303 c.111T>C synonymous_variant 0.79 isoniazid
ahpC 2726311 p.Ser40Asn missense_variant 0.74 isoniazid
ahpC 2726315 p.Asp41Glu missense_variant 0.72 isoniazid
ahpC 2726318 p.Glu42Asp missense_variant 0.72 isoniazid
ahpC 2726322 p.Pro44Ala missense_variant 0.72 isoniazid
ahpC 2726330 c.138G>A synonymous_variant 0.72 isoniazid Not assoc w R - Interim
ahpC 2726336 c.144G>C synonymous_variant 0.72 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.87 isoniazid
ahpC 2726357 c.165A>G synonymous_variant 0.75 isoniazid Not assoc w R - Interim
ahpC 2726366 c.174G>C synonymous_variant 0.62 isoniazid
ahpC 2726528 c.336C>G synonymous_variant 0.5 isoniazid
ahpC 2726540 c.348C>G synonymous_variant 0.54 isoniazid
ahpC 2726543 c.351A>G synonymous_variant 0.54 isoniazid
ahpC 2726546 c.354C>G synonymous_variant 0.5 isoniazid
ahpC 2726551 p.Gln120Leu missense_variant 0.47 isoniazid
ahpC 2726556 p.Ala122Thr missense_variant 0.47 isoniazid Uncertain significance
ahpC 2726564 c.372C>G synonymous_variant 0.55 isoniazid Not assoc w R - Interim
ahpC 2726579 c.387T>C synonymous_variant 0.63 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.64 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.64 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.63 isoniazid
ahpC 2726601 p.Ile137Leu missense_variant 0.63 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.79 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.83 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.73 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.73 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.67 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.67 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.67 isoniazid Not assoc w R - Interim
ahpC 2726693 c.501C>G synonymous_variant 0.65 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.62 isoniazid
ahpC 2726717 c.525A>G synonymous_variant 0.47 isoniazid
Rv2477c 2782828 c.1215T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782841 p.Thr401Asn missense_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782847 p.Arg399Lys missense_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782852 c.1191T>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.44 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.58 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.57 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.63 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.67 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.64 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.61 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.61 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.59 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.59 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.61 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.66 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.65 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.56 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.58 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.7 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.72 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.71 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.73 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783179 c.864G>C synonymous_variant 0.68 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.67 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783338 c.705C>T synonymous_variant 0.72 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.58 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.62 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.57 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.59 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.55 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.5 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
ribD 2986832 c.-7C>T upstream_gene_variant 1.0 para-aminosalicylic_acid
Rv2752c 3065013 c.1179G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065018 p.Asn392His missense_variant 0.41 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065028 p.Val388Ile missense_variant 0.41 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065040 c.1152C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065052 c.1140G>A synonymous_variant 0.47 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065055 c.1137T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065262 c.930G>A synonymous_variant 0.57 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065268 c.924A>G synonymous_variant 0.62 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065288 c.904T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065481 c.711T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065487 c.705T>G synonymous_variant 0.5 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065490 c.702A>C synonymous_variant 0.44 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065493 c.699G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065499 c.693A>C synonymous_variant 0.45 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065502 p.Asp230Glu missense_variant 0.4 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065508 c.684T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065511 c.681G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065517 c.675C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065523 c.669C>T synonymous_variant 0.37 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065532 c.660A>G synonymous_variant 0.37 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065535 c.657C>T synonymous_variant 0.37 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065538 c.654G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065541 c.651A>G synonymous_variant 0.37 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3066018 c.174T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066024 c.168T>G synonymous_variant 0.43 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066054 c.138T>G synonymous_variant 0.36 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066066 c.126T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066074 c.118C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066075 c.117A>G synonymous_variant 0.36 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066078 c.114C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066102 c.90C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067376 c.570G>A synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.67 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.68 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.78 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.78 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.76 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.79 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.78 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.65 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.59 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.59 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.64 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.63 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.6 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.45 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.44 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067691 p.Ile85Leu missense_variant 0.36 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067736 p.Phe70Leu missense_variant 0.43 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.33 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.36 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067781 c.165C>A synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.35 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074034 c.438T>C synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.39 para-aminosalicylic_acid
thyA 3074055 p.Glu139Pro missense_variant 0.39 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3074100 p.Asp124Asn missense_variant 0.55 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.52 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.57 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.55 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074163 p.Ala103Thr missense_variant 0.35 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.35 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.35 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3449723 p.Cys407Tyr missense_variant 1.0 ethionamide
whiB7 3569016 c.-337C>T upstream_gene_variant 1.0 kanamycin
amikacin
streptomycin
lpqB 3623630 c.1281G>C synonymous_variant 0.42 rifampicin
bedaquiline
lpqB 3623648 c.1263A>G synonymous_variant 0.5 rifampicin
bedaquiline
lpqB 3623654 p.Asp419Glu missense_variant 0.45 rifampicin
bedaquiline
lpqB 3623703 p.Ala403Val missense_variant 0.56 rifampicin
bedaquiline
lpqB 3623705 c.1206C>T synonymous_variant 0.56 rifampicin
bedaquiline
lpqB 3623721 p.Ser397Thr missense_variant 0.5 rifampicin
bedaquiline
lpqB 3624350 c.561G>T synonymous_variant 0.77 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
lpqB 3624486 p.Asp142Gly missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625510 c.-600T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
lpqB 3625513 c.-603G>C upstream_gene_variant 0.29 rifampicin
bedaquiline
lpqB 3625518 c.-608T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625525 c.-615G>C upstream_gene_variant 0.3 rifampicin
bedaquiline
lpqB 3625528 c.-618G>T upstream_gene_variant 0.33 rifampicin
bedaquiline
lpqB 3625537 c.-627T>C upstream_gene_variant 0.38 rifampicin
bedaquiline
lpqB 3625543 c.-633G>C upstream_gene_variant 0.42 rifampicin
bedaquiline
lpqB 3625549 c.-639G>A upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3625569 c.1045T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.47 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.45 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.54 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.5 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.44 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.38 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.39 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.36 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.36 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.43 rifampicin
bedaquiline
lpqB 3625749 c.-839C>T upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.46 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.48 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626110 c.504C>G synonymous_variant 0.3 rifampicin
bedaquiline
mtrB 3626124 p.Ala164Ser missense_variant 0.39 rifampicin
bedaquiline
mtrB 3626125 c.489C>G synonymous_variant 0.39 rifampicin
bedaquiline
mtrB 3626155 p.Ala153Ser missense_variant 0.38 rifampicin
bedaquiline
mtrB 3626158 c.456C>T synonymous_variant 0.38 rifampicin
bedaquiline
mtrB 3626161 c.453C>A synonymous_variant 0.35 rifampicin
bedaquiline
mtrB 3626170 c.444T>C synonymous_variant 0.38 rifampicin
bedaquiline
mtrB 3626179 c.435A>T synonymous_variant 0.38 rifampicin
bedaquiline
mtrB 3626185 c.429T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626188 p.Ser142Thr missense_variant 0.38 rifampicin
bedaquiline
mtrB 3626191 c.423C>G synonymous_variant 0.38 rifampicin
bedaquiline
mtrB 3626194 c.420T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626203 c.411G>A synonymous_variant 0.4 rifampicin
bedaquiline
mtrB 3626206 c.408T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3626209 c.405T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.41 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.41 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.47 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.47 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3626912 c.-299T>G upstream_gene_variant 0.52 rifampicin
bedaquiline
mtrB 3626927 c.-314G>C upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.48 rifampicin
bedaquiline
mtrB 3626957 c.-344G>C upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.41 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.41 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.62 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.6 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.57 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.43 rifampicin
bedaquiline
rpoA 3877494 p.Glu338Asp missense_variant 0.41 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.45 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.48 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.47 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.57 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.61 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.63 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.53 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.47 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.44 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.53 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.69 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.72 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.67 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.65 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.66 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.64 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.62 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.74 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.71 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.62 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.48 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.46 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.46 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.5 rifampicin
rpoA 3878181 c.327C>T synonymous_variant 0.45 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.54 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.58 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.58 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.62 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.72 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.61 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.59 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.7 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.78 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.75 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.76 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.79 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.79 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.79 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.79 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.77 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.79 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.81 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.78 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.7 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.64 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.64 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.64 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.58 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.71 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.73 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.63 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.6 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.65 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.65 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.65 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.65 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.67 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.61 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.68 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.7 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.65 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.62 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.66 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.62 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.56 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.54 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.57 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.6 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.72 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.71 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.7 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.69 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.68 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.58 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.62 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.52 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.48 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.6 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.57 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.65 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.63 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.66 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.61 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.59 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.6 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.61 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.55 pretomanid
delamanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.46 pretomanid
delamanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.32 pretomanid
delamanid
ddn 3987111 p.Leu90Val missense_variant 1.0 pretomanid
delamanid
clpC1 4038271 p.Pro812Ala missense_variant 0.32 pyrazinamide
clpC1 4038272 p.Gly811Ser missense_variant 0.32 pyrazinamide
clpC1 4038275 c.2430A>G synonymous_variant 0.32 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038308 p.Val799Ile missense_variant 0.29 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.37 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.36 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.36 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.45 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.45 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.48 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.48 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.56 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.58 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.47 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.47 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.53 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.7 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.66 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.64 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.64 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.61 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.58 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.6 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.6 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.56 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.43 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.45 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.43 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.42 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.62 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.69 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.63 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.64 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.63 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.6 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.59 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.55 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.66 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.74 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.61 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.52 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.52 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.54 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.52 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.35 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.35 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.55 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.55 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.5 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.44 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.5 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.47 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.41 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.38 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.33 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.35 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.4 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.29 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.4 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.36 pyrazinamide
panD 4044746 c.-467_-465delGTGinsATC upstream_gene_variant 0.35 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.4 pyrazinamide
panD 4044758 c.-477C>T upstream_gene_variant 0.4 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.46 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.48 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.48 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.48 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.43 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.45 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.45 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.41 pyrazinamide
panD 4044848 c.-567T>G upstream_gene_variant 0.41 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.39 pyrazinamide
panD 4044986 c.-705C>G upstream_gene_variant 0.32 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.35 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.4 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.57 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.57 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.61 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.58 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.6 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.71 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.75 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.75 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.64 pyrazinamide
panD 4045088 c.-807T>C upstream_gene_variant 0.57 pyrazinamide
panD 4045094 c.-813T>C upstream_gene_variant 0.5 pyrazinamide
panD 4045097 c.-816T>C upstream_gene_variant 0.5 pyrazinamide
panD 4045105 c.-824T>C upstream_gene_variant 0.5 pyrazinamide
panD 4045112 c.-831A>G upstream_gene_variant 0.42 pyrazinamide
panD 4045115 c.-834G>C upstream_gene_variant 0.4 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4138695 p.Pro354Asp missense_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139597 c.159C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139601 p.Arg52Gln missense_variant 0.5 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139611 p.Ile49Val missense_variant 0.47 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139615 c.141G>A synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
glpK 4139651 p.His35Glu missense_variant 0.55 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240249 p.Asp129Glu missense_variant 0.33 ethambutol
embC 4240258 c.396T>G synonymous_variant 0.33 ethambutol
embC 4240267 c.405T>C synonymous_variant 0.33 ethambutol
embC 4240270 c.408T>C synonymous_variant 0.33 ethambutol
embC 4240277 p.Leu139Val missense_variant 0.33 ethambutol
embC 4240282 c.420C>G synonymous_variant 0.33 ethambutol
embC 4240284 p.Thr141Ser missense_variant 0.33 ethambutol
embC 4240297 c.435T>C synonymous_variant 0.35 ethambutol
embC 4240543 c.681G>C synonymous_variant 0.24 ethambutol
embC 4240558 c.696C>G synonymous_variant 0.27 ethambutol
embC 4240561 c.699C>G synonymous_variant 0.29 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.26 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.29 ethambutol
embC 4240669 c.807G>C synonymous_variant 0.38 ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240677 p.Gly272Ala missense_variant 0.36 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.42 ethambutol
embC 4240693 c.831T>G synonymous_variant 0.5 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.57 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.48 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.51 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.52 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.56 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.54 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.52 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.42 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.4 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.4 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.43 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.41 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.41 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.56 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.56 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.62 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.41 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.41 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.38 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>A synonymous_variant 0.4 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.4 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.43 ethambutol Not assoc w R - Interim
embC 4241548 c.1686T>C synonymous_variant 0.46 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.46 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.46 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.46 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.46 ethambutol
embC 4242176 p.Pro772Ser missense_variant 1.0 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245083 c.1851A>C synonymous_variant 0.44 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.57 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.57 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.6 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.72 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.71 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.67 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.67 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.63 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.62 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.6 ethambutol
embA 4245704 c.2472G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4245785 c.2553G>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4245807 c.-707_-705delTTAinsCTG upstream_gene_variant 0.29 ethambutol
embB 4246184 c.-330A>C upstream_gene_variant 0.43 ethambutol
embB 4246196 c.-318C>G upstream_gene_variant 0.45 ethambutol
embB 4246205 c.-309A>G upstream_gene_variant 0.48 ethambutol
embB 4246211 c.-303T>C upstream_gene_variant 0.43 ethambutol
embB 4246250 c.-264G>C upstream_gene_variant 0.36 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.39 ethambutol
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247413 c.900C>T synonymous_variant 0.54 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.48 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.48 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.52 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.52 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.52 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.55 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.53 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.61 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.64 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.66 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.62 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.57 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.53 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.57 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.59 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.62 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.63 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.64 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.61 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247746 c.1233C>T synonymous_variant 0.3 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.38 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.48 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.5 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.42 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.42 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.5 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.5 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.5 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.53 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.53 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.57 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.61 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.56 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.56 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.58 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.56 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.55 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.5 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.47 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.45 ethambutol
embB 4247932 c.1419C>G synonymous_variant 0.38 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.35 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.35 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.33 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.32 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.44 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.44 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.44 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.43 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.49 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.49 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.49 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.48 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.48 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.47 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.47 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.47 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embB 4248199 c.1686A>G synonymous_variant 0.53 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.53 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.52 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.5 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.57 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.5 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.48 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.44 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.41 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.41 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.34 ethambutol
embB 4248361 c.1848A>C synonymous_variant 0.34 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.34 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.37 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.42 ethambutol
embB 4248407 p.Leu632Val missense_variant 0.39 ethambutol
embB 4248410 p.Phe633Leu missense_variant 0.38 ethambutol
embB 4248419 p.Leu636Met missense_variant 0.35 ethambutol
embB 4248425 c.1912T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4248430 c.1917T>C synonymous_variant 0.3 ethambutol
embB 4248432 p.Trp640Phe missense_variant 0.3 ethambutol
embB 4248457 c.1944T>C synonymous_variant 0.27 ethambutol
embB 4248472 c.1959T>C synonymous_variant 0.23 ethambutol
embB 4248475 c.1962G>C synonymous_variant 0.22 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.41 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.44 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.41 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.43 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.45 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.42 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.4 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.4 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.4 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.4 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.42 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.37 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.37 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.37 ethambutol
embB 4249594 c.3081G>C synonymous_variant 0.32 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.35 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.36 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.36 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.36 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
aftB 4268182 p.Phe219Leu missense_variant 0.33 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 0.32 ethambutol
aftB 4268205 p.Val211Ala missense_variant 0.32 ethambutol
aftB 4268213 c.624T>G synonymous_variant 0.33 ethambutol
aftB 4268225 c.612G>C synonymous_variant 0.32 ethambutol
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R