TB-Profiler result

Run: 8f9d7d60-b4f0-40b8-9920-e84bf1f8991a
Summary

Run ID: 8f9d7d60-b4f0-40b8-9920-e84bf1f8991a

Sample name:

Date: 18-03-2024 13:22:28

Number of reads: 7881908

Percentage reads mapped: 30.93

Median coverage: 87

Strain: lineage6.1.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage6 West-Africa 2 RD702 0.99
lineage6.1.1 West-Africa 2 RD702 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser441Ala Assoc w R - interim
isoniazid katG p.Ser140Asn Uncertain significance
ethambutol
pyrazinamide
moxifloxacin
levofloxacin
bedaquiline
delamanid
pretomanid
linezolid
streptomycin
amikacin rrs n.1402C>A Uncertain significance
n.1484G>T Assoc w R - interim
kanamycin rrs n.1402C>A Uncertain significance
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance
n.1484G>T Assoc w R
clofazimine
ethionamide
para-aminosalicylic_acid
cycloserine
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761127 p.Ser441Ala missense_variant 0.15 rifampicin Assoc w R - interim
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Uncertain significance
aminoglycosides Uncertain significance
amikacin Uncertain significance
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.45 kanamycin Assoc w R
capreomycin Assoc w R
aminoglycosides Uncertain significance
amikacin Assoc w R - interim
katG 2155693 p.Ser140Asn missense_variant 0.16 isoniazid Uncertain significance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6169 c.930C>G synonymous_variant 0.19 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 6190 c.951A>G synonymous_variant 0.23 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 6200 c.962_963insTG frameshift_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 6352 c.-950C>G upstream_gene_variant 0.15 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 6362 c.-940_-938delTTGinsCTC upstream_gene_variant 0.14 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 6446 p.Ala403Ser missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 6680 c.-622C>T upstream_gene_variant 0.13 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.13 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.14 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.19 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 6970 p.Asp577Glu missense_variant 0.23 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.28 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 7005 p.Gly589Ala missense_variant 0.31 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7012 c.-290G>C upstream_gene_variant 0.31 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7021 c.-281G>T upstream_gene_variant 0.25 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.19 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 7038 p.Lys600Arg missense_variant 0.13 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.15 fluoroquinolones
moxifloxacin
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 7075 c.-227T>C upstream_gene_variant 0.15 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.16 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 7088 p.Asp617Asn missense_variant 0.14 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7093 c.-209T>C upstream_gene_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7100 c.-202T>C upstream_gene_variant 0.13 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 7835 c.534A>G synonymous_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7859 c.558A>C synonymous_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8294 c.993T>C synonymous_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.16 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.13 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8493 p.Leu398Phe missense_variant 0.99 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.99 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
fgd1 491472 c.690A>G synonymous_variant 0.1 delamanid
fgd1 491580 p.Ile266Met missense_variant 0.11 delamanid
fgd1 491668 p.Lys296Glu missense_variant 0.97 delamanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 delamanid
rpoB 760148 p.Asp114Glu missense_variant 0.14 rifampicin
rpoB 760157 c.351A>G synonymous_variant 0.22 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.25 rifampicin
rpoB 760196 c.390C>T synonymous_variant 0.21 rifampicin
rpoB 760211 c.405C>T synonymous_variant 0.11 rifampicin
rpoB 760244 c.438G>C synonymous_variant 0.11 rifampicin
rpoB 760274 p.Glu156Asp missense_variant 0.16 rifampicin Uncertain significance
rpoB 760283 c.477G>C synonymous_variant 0.11 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.13 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.24 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.3 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.33 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.38 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.49 rifampicin
rpoB 760433 p.Asp209Glu missense_variant 0.14 rifampicin
rpoB 760434 p.Val210Ile missense_variant 0.14 rifampicin
rpoB 760457 c.651C>T synonymous_variant 0.31 rifampicin
rpoB 760463 c.657C>T synonymous_variant 0.35 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.31 rifampicin
rpoB 760481 c.675G>T synonymous_variant 0.34 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.33 rifampicin
rpoB 760514 c.708C>A synonymous_variant 0.25 rifampicin
rpoB 760518 p.Thr238Ser missense_variant 0.3 rifampicin
rpoB 760522 p.Ser239Thr missense_variant 0.3 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.31 rifampicin
rpoB 760541 c.735G>T synonymous_variant 0.33 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.19 rifampicin
rpoB 760574 c.768G>C synonymous_variant 0.2 rifampicin
rpoB 760589 c.783C>G synonymous_variant 0.1 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.19 rifampicin
rpoB 760855 p.Thr350Ile missense_variant 1.0 rifampicin Uncertain significance
rpoB 760916 c.1110C>T synonymous_variant 0.25 rifampicin
rpoB 760919 c.1113C>T synonymous_variant 0.26 rifampicin
rpoB 760940 c.1134G>C synonymous_variant 0.29 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin
rpoB 760969 p.Ser388Leu missense_variant 1.0 rifampicin Uncertain significance
rpoB 760997 c.1191G>C synonymous_variant 0.12 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.22 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.16 rifampicin
rpoB 761037 c.1231T>C synonymous_variant 0.11 rifampicin
rpoB 761051 c.1245G>T synonymous_variant 0.27 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.28 rifampicin
rpoB 761060 c.1254C>G synonymous_variant 0.3 rifampicin
rpoB 761084 c.1278C>A synonymous_variant 0.19 rifampicin
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.14 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.12 rifampicin
rpoB 761126 c.1320G>C synonymous_variant 0.15 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.29 rifampicin
rpoB 761133 c.1327T>C synonymous_variant 0.28 rifampicin
rpoB 761138 c.1332C>G synonymous_variant 0.14 rifampicin
rpoB 761147 c.1341C>T synonymous_variant 0.35 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.22 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.25 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.17 rifampicin
rpoB 761180 c.1374A>G synonymous_variant 0.2 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.22 rifampicin
rpoB 761198 c.1392G>C synonymous_variant 0.23 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.16 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.39 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.31 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.27 rifampicin
rpoB 761255 c.1449T>G synonymous_variant 0.11 rifampicin
rpoB 761264 c.1458_1459insG frameshift_variant 0.13 rifampicin
rpoB 761273 c.1467T>C synonymous_variant 0.22 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.31 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.24 rifampicin
rpoB 761333 c.1527G>C synonymous_variant 0.2 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.13 rifampicin
rpoB 761573 c.1767C>G synonymous_variant 0.23 rifampicin
rpoB 761579 c.1773G>C synonymous_variant 0.39 rifampicin
rpoB 761600 c.1794T>C synonymous_variant 0.22 rifampicin
rpoB 761603 c.1797C>G synonymous_variant 0.21 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.25 rifampicin
rpoB 761615 c.1809A>G synonymous_variant 0.38 rifampicin
rpoB 761627 c.1821C>T synonymous_variant 0.15 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 1.0 rifampicin Uncertain significance
rpoB 761948 c.2142G>C synonymous_variant 0.14 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.14 rifampicin
rpoB 761969 c.2163G>A synonymous_variant 0.17 rifampicin
rpoB 762003 p.Asn733Gln missense_variant 0.11 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.14 rifampicin
rpoB 762014 c.2208C>G synonymous_variant 0.13 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.15 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.31 rifampicin
rpoB 762062 c.2256T>C synonymous_variant 0.33 rifampicin
rpoB 762065 c.2259T>C synonymous_variant 0.33 rifampicin
rpoB 762080 c.2274G>C synonymous_variant 0.32 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.35 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.27 rifampicin
rpoB 762128 c.2322G>C synonymous_variant 0.19 rifampicin
rpoB 762158 c.2352G>C synonymous_variant 0.12 rifampicin
rpoC 762452 c.-918G>C upstream_gene_variant 0.1 rifampicin
rpoC 762818 c.-552C>G upstream_gene_variant 0.11 rifampicin
rpoC 762827 c.-543G>T upstream_gene_variant 0.15 rifampicin
rpoC 762831 c.-539_-538delAGinsTC upstream_gene_variant 0.13 rifampicin
rpoC 762857 c.-513C>G upstream_gene_variant 0.12 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.12 rifampicin
rpoC 762863 c.-507T>C upstream_gene_variant 0.11 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.3 rifampicin
rpoC 762896 c.-474G>C upstream_gene_variant 0.48 rifampicin
rpoC 762917 c.-453C>G upstream_gene_variant 0.52 rifampicin
rpoC 762923 c.-447C>G upstream_gene_variant 0.54 rifampicin
rpoC 762929 c.-441G>C upstream_gene_variant 0.52 rifampicin
rpoC 762947 c.-423C>G upstream_gene_variant 0.16 rifampicin
rpoC 762959 c.-411G>C upstream_gene_variant 0.52 rifampicin
rpoC 762962 c.-408C>T upstream_gene_variant 0.52 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.36 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.43 rifampicin
rpoC 762995 c.-375G>T upstream_gene_variant 0.4 rifampicin
rpoC 763028 c.-342T>C upstream_gene_variant 0.3 rifampicin
rpoC 763031 c.-339T>C upstream_gene_variant 1.0 rifampicin
rpoC 763043 c.-327G>C upstream_gene_variant 0.18 rifampicin
rpoB 763075 p.Thr1090Ile missense_variant 0.14 rifampicin
rpoB 763077 p.Val1091Leu missense_variant 0.14 rifampicin
rpoC 763082 c.-288C>T upstream_gene_variant 0.12 rifampicin
rpoC 763094 c.-276G>C upstream_gene_variant 0.51 rifampicin
rpoC 763115 c.-255T>C upstream_gene_variant 0.59 rifampicin
rpoB 763126 p.Pro1107His missense_variant 0.19 rifampicin
rpoC 763133 c.-237G>C upstream_gene_variant 0.16 rifampicin
rpoC 763136 c.-234C>T upstream_gene_variant 0.41 rifampicin
rpoC 763160 c.-210G>C upstream_gene_variant 0.35 rifampicin
rpoC 763166 c.-204A>G upstream_gene_variant 0.32 rifampicin
rpoC 763172 c.-198G>C upstream_gene_variant 0.27 rifampicin
rpoC 763187 c.-183C>G upstream_gene_variant 0.16 rifampicin
rpoC 763363 c.-7G>A upstream_gene_variant 0.15 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.23 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.11 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.1 rifampicin
rpoC 763420 c.51G>C synonymous_variant 0.1 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.11 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.11 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.22 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.27 rifampicin
rpoC 763501 c.132C>T synonymous_variant 0.31 rifampicin
rpoC 763505 c.136C>T synonymous_variant 0.33 rifampicin
rpoC 763528 c.159G>T synonymous_variant 0.34 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.32 rifampicin
rpoC 763534 c.165T>C synonymous_variant 0.32 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.35 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.43 rifampicin
rpoC 763570 c.201G>T synonymous_variant 0.42 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.41 rifampicin
rpoC 763630 c.261G>C synonymous_variant 0.31 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.29 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.25 rifampicin
rpoC 763660 c.291T>C synonymous_variant 0.34 rifampicin
rpoC 763666 c.297G>T synonymous_variant 0.22 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.21 rifampicin
rpoC 763672 c.303C>G synonymous_variant 0.36 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.34 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.14 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.16 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.2 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.28 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.24 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.24 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.19 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.11 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.11 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.1 rifampicin
rpoC 764002 c.633C>T synonymous_variant 0.11 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.36 rifampicin
rpoC 764143 c.774G>C synonymous_variant 0.35 rifampicin
rpoC 764147 p.Ser260Ala missense_variant 0.34 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.39 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.14 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.13 rifampicin
rpoC 764266 c.897T>G synonymous_variant 0.13 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.26 rifampicin
rpoC 764284 c.915G>C synonymous_variant 0.29 rifampicin
rpoC 764296 c.927G>C synonymous_variant 0.34 rifampicin
rpoC 764316 p.Ala316Val missense_variant 0.19 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.32 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.23 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.21 rifampicin
rpoC 764359 c.990C>G synonymous_variant 0.21 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.26 rifampicin
rpoC 764371 c.1002G>C synonymous_variant 0.2 rifampicin
rpoC 764377 c.1008C>G synonymous_variant 0.16 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.13 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.12 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.14 rifampicin
rpoC 764470 c.1101C>G synonymous_variant 0.25 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.44 rifampicin
rpoC 764498 p.Ser377Ala missense_variant 0.35 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.43 rifampicin
rpoC 764509 c.1140G>C synonymous_variant 0.13 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.26 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.18 rifampicin
rpoC 764548 c.1179G>T synonymous_variant 0.24 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.27 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.29 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.35 rifampicin
rpoC 764602 c.1233C>A synonymous_variant 0.19 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.5 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.54 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.25 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.49 rifampicin
rpoC 764635 c.1266C>G synonymous_variant 0.28 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.46 rifampicin
rpoC 764660 p.Val431Ile missense_variant 0.27 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.28 rifampicin
rpoC 764677 c.1308C>G synonymous_variant 0.31 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.21 rifampicin
rpoC 764706 p.Leu446His missense_variant 0.35 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.23 rifampicin
rpoC 764737 c.1368G>C synonymous_variant 0.12 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.18 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.17 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.21 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.16 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.12 rifampicin
rpoC 765082 c.1713G>C synonymous_variant 0.11 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.11 rifampicin
rpoC 765089 c.1720_1722delTTGinsCTC synonymous_variant 0.11 rifampicin
rpoC 765478 c.2109T>G synonymous_variant 0.23 rifampicin
rpoC 765493 c.2124G>C synonymous_variant 0.3 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.29 rifampicin
rpoC 765844 c.2475C>G synonymous_variant 0.1 rifampicin
rpoC 765856 c.2487T>C synonymous_variant 0.21 rifampicin
rpoC 765871 c.2502T>C synonymous_variant 0.21 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.23 rifampicin
rpoC 765907 c.2538G>C synonymous_variant 0.15 rifampicin
rpoC 765908 p.Leu847Ala missense_variant 0.16 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.16 rifampicin
rpoC 766231 c.2862T>C synonymous_variant 1.0 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.14 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.22 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.24 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.13 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.13 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.16 rifampicin
rpoC 766799 p.Ala1144Ser missense_variant 0.16 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.15 rifampicin
rpoC 766807 c.3438T>C synonymous_variant 0.17 rifampicin
rpoC 766837 c.3468G>C synonymous_variant 0.28 rifampicin
rpoC 766843 c.3474T>G synonymous_variant 0.24 rifampicin
rpoC 766858 c.3489C>T synonymous_variant 0.23 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.22 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.2 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.17 rifampicin
rpoC 766987 c.3618G>C synonymous_variant 0.17 rifampicin
rpoC 766990 c.3621G>C synonymous_variant 0.21 rifampicin
rpoC 767044 c.3675G>C synonymous_variant 0.29 rifampicin
rpoC 767068 c.3699G>C synonymous_variant 0.16 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.15 rifampicin
rpoC 767104 c.3735C>G synonymous_variant 0.11 rifampicin
rpoC 767106 p.Asn1246Ile missense_variant 0.11 rifampicin
rpoC 767113 c.3744G>C synonymous_variant 0.22 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.25 rifampicin
rpoC 767146 c.3777G>C synonymous_variant 0.17 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Uncertain significance
rpsL 781643 c.84G>C synonymous_variant 0.13 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.1 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.12 streptomycin
rpsL 781664 c.105C>T synonymous_variant 0.16 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.14 streptomycin
rpsL 781706 c.147T>C synonymous_variant 0.15 streptomycin
rpsL 781709 c.150G>T synonymous_variant 0.14 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.25 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.34 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.39 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.17 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.23 streptomycin
rpsL 781781 c.222G>C synonymous_variant 0.26 streptomycin
rpsL 781794 p.Met79Leu missense_variant 0.16 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.37 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.23 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.33 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.3 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.27 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.27 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.33 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.32 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.32 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.34 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.4 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.41 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.4 streptomycin
rpsL 781913 c.354C>A synonymous_variant 0.37 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.44 streptomycin
rplC 800672 c.-137G>C upstream_gene_variant 0.14 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.15 linezolid
rplC 800702 c.-107G>T upstream_gene_variant 0.12 linezolid Uncertain significance
rplC 800703 c.-106_-104delTTGinsCTC upstream_gene_variant 0.21 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.11 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.11 linezolid
rplC 800762 c.-47T>C upstream_gene_variant 0.1 linezolid
rplC 800768 c.-41C>G upstream_gene_variant 0.11 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.1 linezolid
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 delamanid Uncertain significance
fbiC 1303794 c.864A>G synonymous_variant 0.1 delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.16 delamanid
fbiC 1304019 c.1089C>T synonymous_variant 0.17 delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.16 delamanid
fbiC 1304580 c.1650T>G synonymous_variant 0.11 delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.21 delamanid
fbiC 1304628 c.1698G>C synonymous_variant 0.16 delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.14 delamanid
fbiC 1304727 c.1797A>G synonymous_variant 0.14 delamanid
fbiC 1304751 c.1821C>G synonymous_variant 0.25 delamanid
fbiC 1304763 c.1833C>G synonymous_variant 0.22 delamanid
fbiC 1304781 c.1851G>C synonymous_variant 0.14 delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.14 delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.16 delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.18 delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.17 delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.13 delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.13 delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.12 delamanid
fbiC 1304961 c.2031C>G synonymous_variant 0.12 delamanid
Rv1258c 1406685 p.Val219Ala missense_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
embR 1416633 p.Leu239Val missense_variant 1.0 ethambutol Uncertain significance
atpE 1461251 c.207G>T synonymous_variant 1.0 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1471878 n.33C>T non_coding_transcript_exon_variant 0.27 linezolid
kanamycin
capreomycin Uncertain significance
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.6 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.6 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.47 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.41 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472042 n.197T>C non_coding_transcript_exon_variant 0.28 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472045 n.200T>G non_coding_transcript_exon_variant 0.17 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.41 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.7 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.72 linezolid
kanamycin Uncertain significance
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.39 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.43 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.53 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.22 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.82 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.85 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.55 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.78 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.17 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.15 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.42 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472333 n.488G>A non_coding_transcript_exon_variant 0.2 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.26 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.38 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.58 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.6 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472389 n.544G>A non_coding_transcript_exon_variant 0.58 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.58 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.58 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.19 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472489 n.644A>C non_coding_transcript_exon_variant 0.15 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.51 linezolid
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.5 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.51 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1472507 n.662C>T non_coding_transcript_exon_variant 0.55 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.18 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.7 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.69 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472571 n.726G>A non_coding_transcript_exon_variant 0.69 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.63 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472606 n.761C>G non_coding_transcript_exon_variant 0.64 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.17 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.68 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472623 n.778A>C non_coding_transcript_exon_variant 0.64 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472645 n.800G>C non_coding_transcript_exon_variant 0.53 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.46 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472660 n.815T>A non_coding_transcript_exon_variant 0.66 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.58 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.32 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472666 n.821G>T non_coding_transcript_exon_variant 0.33 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.15 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.4 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.39 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472694 n.849C>A non_coding_transcript_exon_variant 0.14 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.21 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472701 n.856T>C non_coding_transcript_exon_variant 0.19 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472714 n.869A>T non_coding_transcript_exon_variant 0.72 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.62 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.6 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.27 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.19 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.2 linezolid
kanamycin Uncertain significance
capreomycin
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.43 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.51 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.49 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.66 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.65 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.13 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.67 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.63 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.12 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.12 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.74 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472993 n.1148G>T non_coding_transcript_exon_variant 0.61 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.63 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.6 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.62 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.62 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.19 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.18 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473097 n.1252G>A non_coding_transcript_exon_variant 0.45 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.64 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.6 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.49 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.49 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.5 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.29 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.24 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473134 n.1289T>C non_coding_transcript_exon_variant 0.26 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.4 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473147 n.1302G>A non_coding_transcript_exon_variant 0.46 linezolid
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1473164 n.1319C>T non_coding_transcript_exon_variant 0.55 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.56 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.58 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473269 n.1424C>T non_coding_transcript_exon_variant 0.51 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.66 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.35 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.55 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.41 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473320 n.1475G>A non_coding_transcript_exon_variant 0.41 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473324 n.1479G>A non_coding_transcript_exon_variant 0.42 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin
aminoglycosides
streptomycin
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.12 linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.14 linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.15 linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.32 linezolid
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.32 linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.32 linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.44 linezolid
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.41 linezolid
rrl 1473828 n.173_174delTG non_coding_transcript_exon_variant 0.17 linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.13 linezolid
rrl 1473834 n.178_179insTAG non_coding_transcript_exon_variant 0.23 linezolid
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.45 linezolid
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.45 linezolid
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.43 linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.41 linezolid
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.29 linezolid
rrl 1474166 n.509G>A non_coding_transcript_exon_variant 0.36 linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.5 linezolid
rrl 1474184 n.527C>A non_coding_transcript_exon_variant 0.49 linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.57 linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.43 linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.7 linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.77 linezolid
rrl 1474265 n.608G>T non_coding_transcript_exon_variant 0.55 linezolid
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.1 linezolid
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.62 linezolid Uncertain significance
rrl 1474275 n.618T>A non_coding_transcript_exon_variant 0.49 linezolid
rrl 1474280 n.623C>T non_coding_transcript_exon_variant 0.14 linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.71 linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.62 linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.14 linezolid
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.49 linezolid
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.52 linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.64 linezolid
rrl 1474374 n.717T>G non_coding_transcript_exon_variant 0.59 linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.66 linezolid
rrl 1474414 n.757C>T non_coding_transcript_exon_variant 0.24 linezolid
rrl 1474466 n.809G>A non_coding_transcript_exon_variant 0.15 linezolid Uncertain significance
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.16 linezolid
rrl 1474488 n.831G>C non_coding_transcript_exon_variant 0.42 linezolid
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.57 linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.51 linezolid
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.66 linezolid
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.65 linezolid
rrl 1474516 n.859C>G non_coding_transcript_exon_variant 0.62 linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.82 linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.11 linezolid
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.77 linezolid
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.8 linezolid
rrl 1474601 n.944C>T non_coding_transcript_exon_variant 0.76 linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.1 linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.73 linezolid
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.68 linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.57 linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.64 linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.68 linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.8 linezolid
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.76 linezolid
rrl 1474710 n.1053T>G non_coding_transcript_exon_variant 0.19 linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.17 linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.25 linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.44 linezolid
rrl 1474790 n.1133C>T non_coding_transcript_exon_variant 0.21 linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.72 linezolid
rrl 1474800 n.1143T>C non_coding_transcript_exon_variant 0.53 linezolid
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.23 linezolid
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.14 linezolid
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.78 linezolid
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.75 linezolid
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.61 linezolid
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.72 linezolid
rrl 1474844 n.1187G>T non_coding_transcript_exon_variant 0.12 linezolid
rrl 1474866 n.1209C>A non_coding_transcript_exon_variant 0.11 linezolid
rrl 1474869 n.1212G>T non_coding_transcript_exon_variant 0.1 linezolid
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.11 linezolid
rrl 1474902 n.1245T>C non_coding_transcript_exon_variant 0.11 linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.84 linezolid
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.63 linezolid
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.83 linezolid
rrl 1474920 n.1263G>A non_coding_transcript_exon_variant 0.74 linezolid
rrl 1474935 n.1278A>G non_coding_transcript_exon_variant 0.15 linezolid
rrl 1475039 n.1382A>G non_coding_transcript_exon_variant 0.15 linezolid
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.2 linezolid
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.2 linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.21 linezolid
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.17 linezolid
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.34 linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.3 linezolid
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.31 linezolid
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.25 linezolid
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.22 linezolid
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.17 linezolid
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.37 linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.24 linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.2 linezolid
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.18 linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.27 linezolid
rrl 1475692 n.2035G>C non_coding_transcript_exon_variant 0.58 linezolid
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.21 linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.18 linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.27 linezolid
rrl 1475776 n.2119G>C non_coding_transcript_exon_variant 0.11 linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.66 linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.12 linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1475892 n.2235A>G non_coding_transcript_exon_variant 0.16 linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.72 linezolid
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.52 linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.53 linezolid
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.19 linezolid
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.63 linezolid
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.64 linezolid
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.57 linezolid
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.57 linezolid
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.16 linezolid
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.77 linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.8 linezolid Uncertain significance
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.73 linezolid
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.51 linezolid
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.58 linezolid Uncertain significance
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.6 linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.46 linezolid
rrl 1476044 n.2387T>A non_coding_transcript_exon_variant 0.18 linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.18 linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.32 linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.3 linezolid
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.19 linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.12 linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.5 linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.71 linezolid
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.82 linezolid
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.69 linezolid
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.69 linezolid
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.12 linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.79 linezolid
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.78 linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.1 linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.8 linezolid
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.81 linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.84 linezolid
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.83 linezolid
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.81 linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.71 linezolid
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.19 linezolid
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.2 linezolid
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.19 linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.32 linezolid
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.43 linezolid
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.25 linezolid
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.58 linezolid
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.63 linezolid
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.58 linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.79 linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.72 linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.38 linezolid
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.2 linezolid
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.37 linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.48 linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.45 linezolid
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.1 linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.22 linezolid
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.21 linezolid
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.16 linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.14 linezolid
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.1 linezolid
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.1 linezolid
rrl 1476630 n.2973A>T non_coding_transcript_exon_variant 0.11 linezolid
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.12 linezolid
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.1 linezolid
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.11 linezolid
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.11 linezolid
inhA 1674434 p.Val78Ala missense_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
rpsA 1833727 c.186G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.16 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.11 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.14 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.2 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.36 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.12 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.19 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834108 c.567C>A synonymous_variant 0.2 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834135 c.594G>C synonymous_variant 0.11 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834243 c.702G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.12 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.11 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.15 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.1 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.1 pyrazinamide
rpsA 1834307 p.Asp256Thr missense_variant 0.1 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.16 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.14 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.39 pyrazinamide
rpsA 1834427 p.Ile296Val missense_variant 0.18 pyrazinamide
rpsA 1834431 p.Val297Ala missense_variant 0.19 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCTC synonymous_variant 0.43 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.39 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834600 c.1059G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834612 c.1071G>T synonymous_variant 0.19 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.11 pyrazinamide
rpsA 1834653 p.Glu371Ala missense_variant 0.17 pyrazinamide
rpsA 1834663 c.1122C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.33 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.26 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.19 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Uncertain significance
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid
katG 2155674 c.438G>C synonymous_variant 0.24 isoniazid
katG 2155689 c.421_423delTTGinsCTC synonymous_variant 0.21 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.19 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.2 isoniazid
katG 2155722 c.390G>T synonymous_variant 0.14 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
kasA 2517917 c.-198G>C upstream_gene_variant 0.15 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.25 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.2 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.11 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
pepQ 2859828 c.591G>T synonymous_variant 0.1 clofazimine
bedaquiline
pepQ 2859834 c.585T>C synonymous_variant 0.11 clofazimine
bedaquiline
pepQ 2859837 c.582G>C synonymous_variant 0.1 clofazimine
bedaquiline
ald 3086667 c.-153C>T upstream_gene_variant 1.0 cycloserine
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 0.98 cycloserine
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0 capreomycin
amikacin
fprA 3475159 p.Asn385Asp missense_variant 1.0 capreomycin Uncertain significance
amikacin Uncertain significance
Rv3236c 3612143 p.Arg325His missense_variant 1.0 pyrazinamide Uncertain significance
fbiB 3641993 c.459A>C synonymous_variant 0.12 delamanid
rpoA 3877613 p.Ile299Val missense_variant 0.24 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.27 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.24 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.17 rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.1 rifampicin
rpoA 3877707 c.801G>A synonymous_variant 0.12 rifampicin
rpoA 3877728 c.780C>G synonymous_variant 0.1 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.1 rifampicin
rpoA 3877739 p.Thr257Ser missense_variant 0.1 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.15 rifampicin
rpoA 3877746 c.762G>C synonymous_variant 0.16 rifampicin
rpoA 3877833 c.675C>G synonymous_variant 0.12 rifampicin
rpoA 3877839 c.669G>C synonymous_variant 0.11 rifampicin
rpoA 3877842 c.666A>C synonymous_variant 0.12 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.19 rifampicin
rpoA 3877968 c.540C>G synonymous_variant 0.18 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.17 rifampicin
rpoA 3877983 c.525C>G synonymous_variant 0.17 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.1 rifampicin
rpoA 3878064 c.444G>T synonymous_variant 0.11 rifampicin
rpoA 3878067 c.441C>T synonymous_variant 0.13 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.16 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.16 rifampicin
rpoA 3878102 p.Val136Ile missense_variant 0.17 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.13 rifampicin
clpC1 4038529 p.Glu726Gln missense_variant 0.1 pyrazinamide
clpC1 4038584 c.2121G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038694 p.Ser671Ala missense_variant 0.15 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038749 c.1956C>A synonymous_variant 0.15 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.12 pyrazinamide
clpC1 4038791 c.1914G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038795 p.Ser637Thr missense_variant 0.28 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038839 c.1866G>T synonymous_variant 0.26 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038890 c.1815G>A synonymous_variant 0.16 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.1 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.1 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.1 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.1 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.12 pyrazinamide
clpC1 4039025 c.1680C>G synonymous_variant 0.1 pyrazinamide
clpC1 4039031 c.1674T>A synonymous_variant 0.1 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039042 p.Ser555Thr missense_variant 0.14 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.15 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039120 p.Ser529Ala missense_variant 0.24 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039239 p.Gly489Ala missense_variant 0.19 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039244 c.1461G>T synonymous_variant 0.17 pyrazinamide
clpC1 4039262 p.Asp481Glu missense_variant 0.12 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.33 pyrazinamide
clpC1 4039406 c.1299G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039412 c.1293T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.13 pyrazinamide Uncertain significance
clpC1 4039448 c.1257A>G synonymous_variant 0.11 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.1 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.11 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.11 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.11 pyrazinamide
clpC1 4039499 c.1206G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.11 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.1 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.31 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039694 c.1011G>T synonymous_variant 0.31 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039736 c.969C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039814 c.891C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.14 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039872 p.Thr278Ser missense_variant 0.18 pyrazinamide
clpC1 4039982 c.723G>C synonymous_variant 0.11 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.13 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040063 c.642G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040066 c.639G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040069 c.636G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040108 c.597G>C synonymous_variant 0.12 pyrazinamide
clpC1 4040117 c.588A>G synonymous_variant 0.12 pyrazinamide
clpC1 4040124 p.Glu194Ala missense_variant 0.15 pyrazinamide
clpC1 4040126 c.579C>G synonymous_variant 0.14 pyrazinamide
clpC1 4040615 c.90C>G synonymous_variant 0.12 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.18 pyrazinamide
embC 4240023 p.Gln54Pro missense_variant 1.0 ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Uncertain significance
embC 4241843 p.Leu661Ile missense_variant 1.0 ethambutol Uncertain significance
embA 4242643 c.-590C>T upstream_gene_variant 1.0 ethambutol
embA 4243570 p.Thr113Arg missense_variant 1.0 ethambutol Uncertain significance
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol
embA 4244379 p.Pro383Ser missense_variant 1.0 ethambutol Uncertain significance
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol
embB 4247028 p.Leu172Arg missense_variant 0.19 ethambutol Uncertain significance
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Uncertain significance
aftB 4269258 c.-422C>G upstream_gene_variant 0.11 capreomycin
amikacin
aftB 4269351 c.-515C>T upstream_gene_variant 1.0 capreomycin
amikacin
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Uncertain significance
aftB 4269522 c.-686C>T upstream_gene_variant 1.0 capreomycin
amikacin
aftB 4269606 c.-770T>C upstream_gene_variant 1.0 capreomycin
amikacin
ethA 4326465 p.Ile337Val missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 streptomycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin
gid 4408034 p.Glu57Lys missense_variant 1.0 streptomycin Uncertain significance
gid 4408074 c.129G>A synonymous_variant 1.0 streptomycin