TB-Profiler result

Run: ERR245794
Summary

Run ID: ERR245794

Sample name:

Date: 2024-10-05T07:06:59.811286

Number of reads: 3378280

Percentage reads mapped: 37.83

Median coverage: 57.0

Strain: lineage4.3.4.2.1

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4 Euro-American None 1.0
lineage4.3.4.2.1 Euro-American (LAM) RD174 0.93
lineage4.3.4 Euro-American (LAM) RD174 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Trp412* Assoc w R High-level resistance
ahpC c.-81C>T Uncertain significance Mutation from literature
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2154877 p.Trp412* stop_gained 0.97 isoniazid Assoc w R High-level resistance
ahpC 2726112 c.-81C>T upstream_gene_variant 0.98 isoniazid Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 702 c.702C>G synonymous_variant 0.15 isoniazid
dnaA 705 c.705A>G synonymous_variant 0.16 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.17 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.29 isoniazid
dnaA 753 c.753C>T synonymous_variant 0.29 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.3 isoniazid
dnaA 767 p.Val256Ala missense_variant 0.24 isoniazid
dnaA 769 p.Ala257Ser missense_variant 0.24 isoniazid Uncertain significance
dnaA 783 c.783C>T synonymous_variant 0.19 isoniazid Not assoc w R - Interim
gyrB 5807 p.Val190Ile missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 5819 c.580C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 5824 c.585A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 5848 c.609G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6140 p.Val301Leu missense_variant 0.82 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6793 c.1554T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6808 c.1569C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.19 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7178 c.-124T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7210 p.Asp657Glu missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 7213 c.-89G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7216 c.-86G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7225 c.-77T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 7234 c.1995C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7243 c.-59G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7397 c.96G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7433 c.132G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7613 c.312G>A synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7637 c.336C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7775 c.474C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7886 c.585T>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8191 p.Ala297Gly missense_variant 0.13 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8267 c.966G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 p.Ile328Leu missense_variant 0.3 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8315 c.1014G>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8354 c.1053G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8357 c.1056G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8535 p.Glu412Gln missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8600 c.1299G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8840 c.1539C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8876 c.1575C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9377 c.2076A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>G synonymous_variant 0.14 levofloxacin
moxifloxacin
fgd1 491472 c.690A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491481 c.699C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491490 c.708C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491493 c.711C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491499 c.717G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491508 c.726A>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491512 p.Asn244Glu missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491536 c.754C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491542 c.760T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491563 c.781_783delAGCinsTCG synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491595 c.813C>T synonymous_variant 0.28 pretomanid
delamanid
clofazimine
mshA 575689 c.342G>C synonymous_variant 0.21 isoniazid
ethionamide
mshA 575692 c.345G>A synonymous_variant 0.29 isoniazid
ethionamide
mshA 575704 c.357T>C synonymous_variant 0.35 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.37 isoniazid
ethionamide
mshA 575725 c.378C>G synonymous_variant 0.32 isoniazid
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.31 isoniazid
ethionamide
mshA 575744 p.Ala133Thr missense_variant 0.28 isoniazid Uncertain significance
ethionamide
mshA 575749 c.402C>A synonymous_variant 0.28 isoniazid
ethionamide
mshA 575837 c.490C>T synonymous_variant 0.41 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575842 c.495G>C synonymous_variant 0.45 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.31 isoniazid
ethionamide
ccsA 620625 c.735A>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620631 c.741T>C synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620652 c.762C>G synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620661 c.771C>G synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620694 c.804C>G synonymous_variant 0.36 kanamycin
capreomycin
amikacin
ccsA 620698 p.Val270Ile missense_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620715 c.825C>T synonymous_variant 0.25 kanamycin
capreomycin
amikacin
hadA 731732 c.-198G>A upstream_gene_variant 0.23 isoniazid
hadA 731753 c.-177A>G upstream_gene_variant 0.23 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.2 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.19 isoniazid
nusG 734460 c.207G>C synonymous_variant 0.16 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734478 c.225C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.25 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.16 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.4 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.38 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.36 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.39 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.46 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.45 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.39 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.39 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.29 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.18 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.4 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.25 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760805 c.999G>C synonymous_variant 0.16 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.22 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.22 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.25 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 0.16 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.14 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.15 rifampicin
rpoB 760888 p.Thr361Met missense_variant 0.16 rifampicin
rpoB 760910 c.1104C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.19 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.16 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.16 rifampicin
rpoB 761147 c.1341C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.44 rifampicin
rpoB 761288 c.1482G>T synonymous_variant 0.52 rifampicin
rpoB 761318 c.1512G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.39 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 0.35 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.28 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.18 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761552 c.1746G>C synonymous_variant 0.29 rifampicin
rpoB 761555 c.1749G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.47 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.44 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.26 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.29 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.29 rifampicin
rpoB 761847 p.Cys681Arg missense_variant 0.27 rifampicin Uncertain significance
rpoB 761852 c.2046C>G synonymous_variant 0.28 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.17 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.24 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.45 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>A synonymous_variant 0.32 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.23 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.24 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.23 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.25 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.42 rifampicin
rpoB 762287 c.2481C>T synonymous_variant 0.42 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762308 c.2502G>C synonymous_variant 0.37 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762374 c.-996G>C upstream_gene_variant 0.16 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.17 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.15 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.16 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.17 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.19 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.17 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.25 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.25 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.35 rifampicin Uncertain significance
rpoB 762920 c.3114C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.25 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.35 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.33 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.25 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.2 rifampicin
rpoC 763375 c.6C>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>C synonymous_variant 0.19 rifampicin
rpoC 763414 c.45T>C synonymous_variant 0.2 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.18 rifampicin Uncertain significance
rpoC 763456 c.87A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>T synonymous_variant 0.47 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.45 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.51 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.48 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.49 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.5 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.5 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.5 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.5 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.41 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.29 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.17 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.17 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.23 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.24 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.29 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.29 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.31 rifampicin
rpoC 763882 c.513G>A synonymous_variant 0.33 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.36 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.38 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.33 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.3 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.29 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.25 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.24 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.24 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.2 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.2 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.2 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.2 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764153 p.Gln262Lys missense_variant 0.32 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.3 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.23 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764239 c.870T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 0.25 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.25 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.28 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.32 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.37 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.4 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.44 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.21 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.3 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.31 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.45 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.44 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.47 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.52 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764707 c.1338G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.46 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764851 c.1482C>T synonymous_variant 0.45 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.38 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.38 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.42 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.73 rifampicin Not assoc w R
rpoC 765383 p.Met672Leu missense_variant 0.28 rifampicin Uncertain significance
rpoC 765403 c.2034G>C synonymous_variant 0.21 rifampicin
rpoC 765404 p.Leu679Lys missense_variant 0.23 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.2 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.24 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 0.29 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 0.2 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.21 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.24 rifampicin Uncertain significance
rpoC 765496 c.2127C>G synonymous_variant 0.14 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765811 c.2442T>G synonymous_variant 0.19 rifampicin
rpoC 765814 c.2445A>C synonymous_variant 0.17 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.18 rifampicin
rpoC 765823 c.2454C>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.33 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.34 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.33 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.27 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.25 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766345 c.2976T>C synonymous_variant 0.32 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.19 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.25 rifampicin
rpoC 766579 c.3210C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.28 rifampicin
rpoC 766594 c.3225G>T synonymous_variant 0.26 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.2 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.16 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.16 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.22 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.25 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.34 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.32 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.31 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766981 c.3612T>C synonymous_variant 0.29 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.22 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.21 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.24 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.24 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.49 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767296 c.3927C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767302 c.3933C>A synonymous_variant 0.31 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775697 c.2784G>C synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 775715 c.2766G>A synonymous_variant 0.17 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
mmpL5 775745 p.Met912Leu missense_variant 0.16 bedaquiline
clofazimine
mmpL5 775754 c.2727C>G synonymous_variant 0.17 bedaquiline
clofazimine
mmpL5 775847 c.2634G>A synonymous_variant 0.17 bedaquiline
clofazimine
mmpL5 775856 c.2625T>C synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 775865 c.2616T>G synonymous_variant 0.17 bedaquiline
clofazimine
mmpL5 775886 c.2595A>T synonymous_variant 0.16 bedaquiline
clofazimine
mmpL5 775892 c.2589C>T synonymous_variant 0.21 bedaquiline
clofazimine
mmpL5 775904 c.2577G>A synonymous_variant 0.26 bedaquiline
clofazimine
mmpL5 775909 p.Leu858Phe missense_variant 0.28 bedaquiline
clofazimine
mmpL5 775915 p.Ala856Ser missense_variant 0.28 bedaquiline
clofazimine
mmpL5 775916 c.2565T>C synonymous_variant 0.31 bedaquiline
clofazimine
mmpL5 775921 c.2560C>T synonymous_variant 0.28 bedaquiline
clofazimine
mmpL5 775924 c.2557C>T synonymous_variant 0.28 bedaquiline
clofazimine Not assoc w R - Interim
mmpL5 775951 c.2530C>T synonymous_variant 0.27 bedaquiline
clofazimine
mmpL5 775966 p.Ala839Ser missense_variant 0.19 bedaquiline
clofazimine
mmpL5 776030 c.2451G>C synonymous_variant 0.28 bedaquiline
clofazimine
mmpL5 776053 c.2428T>C synonymous_variant 0.38 bedaquiline
clofazimine
mmpL5 776075 c.2406C>G synonymous_variant 0.34 bedaquiline
clofazimine
mmpL5 776081 c.2400G>C synonymous_variant 0.42 bedaquiline
clofazimine
mmpL5 776084 c.2397C>G synonymous_variant 0.44 bedaquiline
clofazimine
mmpL5 776087 c.2394C>G synonymous_variant 0.44 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Leu missense_variant 0.32 bedaquiline
clofazimine
mmpL5 776120 c.2361C>T synonymous_variant 0.2 bedaquiline
clofazimine
mmpL5 776704 p.Asp593Asn missense_variant 0.14 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781559 c.-1G>C upstream_gene_variant 0.21 streptomycin
rpsL 781572 p.Gln5Asn missense_variant 0.26 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.25 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.24 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.24 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.26 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.27 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.27 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.25 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.26 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.29 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.29 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.24 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.31 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.36 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.42 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.4 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.33 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.31 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.28 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.28 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.25 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.21 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.21 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.25 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.24 streptomycin Uncertain significance
rplC 800516 c.-293G>C upstream_gene_variant 0.27 linezolid
rplC 800543 c.-266C>T upstream_gene_variant 0.31 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.29 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.25 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.22 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.22 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.19 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.21 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.19 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.25 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.27 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.3 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 0.27 linezolid
rplC 800684 c.-125G>A upstream_gene_variant 0.25 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.26 linezolid
rplC 800702 c.-107G>A upstream_gene_variant 0.25 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.26 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.27 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.24 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.24 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.27 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.21 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.17 linezolid
Rv1129c 1254580 c.-46C>G upstream_gene_variant 0.98 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Not assoc w R
fbiC 1303531 p.Met201Leu missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303536 c.606G>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303539 c.609G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304671 p.Val581Thr missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Asp missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>G synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.2 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304751 c.1821C>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
sigE 1364709 c.297T>C synonymous_variant 0.18 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.19 pyrazinamide
sigE 1364721 c.309C>G synonymous_variant 0.21 pyrazinamide
sigE 1364724 c.312C>T synonymous_variant 0.22 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.22 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.16 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.16 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.47 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.45 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.46 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.5 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230delTinsAA non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474710 n.1053T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474711 n.1054G>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474716 n.1059_1063delAAAGCinsCCAAGAGT non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475353 n.1696A>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475354 n.1697A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.68 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.67 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.65 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
inhA 1673682 c.-520G>C upstream_gene_variant 0.15 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1673703 c.-499C>T upstream_gene_variant 0.14 isoniazid
ethionamide
inhA 1673717 c.-485_-484insA upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1673724 c.-478A>G upstream_gene_variant 0.15 isoniazid
ethionamide
inhA 1673877 c.-325C>G upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673905 c.-297T>G upstream_gene_variant 0.29 isoniazid
ethionamide
inhA 1673916 c.-286A>C upstream_gene_variant 0.25 isoniazid
ethionamide
inhA 1673917 c.-285G>C upstream_gene_variant 0.25 isoniazid
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673931 c.-271C>G upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1674123 c.-79T>C upstream_gene_variant 0.14 isoniazid
ethionamide
inhA 1674132 c.-70T>C upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674136 c.-66T>G upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1674141 c.-61T>C upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674147 c.-55C>G upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674153 c.-49G>C upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674651 c.450C>T synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674656 p.Ser152Thr missense_variant 0.19 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674663 c.462G>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674672 c.471C>A synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674690 c.489C>G synonymous_variant 0.22 isoniazid
ethionamide
rpsA 1833628 c.87G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.24 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.35 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.35 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.34 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.34 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1833709 c.168C>T synonymous_variant 0.38 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.34 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.31 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.3 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.31 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.28 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.25 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.27 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.39 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.48 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.52 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.56 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.6 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.5 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.47 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.45 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.42 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.41 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.38 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.41 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.45 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.25 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.37 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.46 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.43 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.4 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.33 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.39 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.3 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.31 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 0.3 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.33 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.38 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.18 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.16 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102638 c.405A>T synonymous_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2102644 c.399A>G synonymous_variant 0.24 isoniazid
delamanid
ethionamide
ndh 2102668 c.375T>C synonymous_variant 0.18 isoniazid
delamanid
ethionamide
ndh 2102671 c.372T>G synonymous_variant 0.15 isoniazid
delamanid
ethionamide
katG 2155691 c.421T>C synonymous_variant 0.19 isoniazid
katG 2155696 p.Ala139Val missense_variant 0.18 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.17 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.16 isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.3 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.32 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.33 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 0.33 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.32 isoniazid
kasA 2517980 c.-135C>T upstream_gene_variant 0.31 isoniazid
kasA 2517989 c.-126T>G upstream_gene_variant 0.28 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.3 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.21 isoniazid
Rv2477c 2782453 c.1590C>T synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782501 c.1542T>C synonymous_variant 0.26 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2782528 c.1515G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3065022 c.1170G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065058 c.1134C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065061 c.1131C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065064 c.1128G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065070 c.1122C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065079 c.1113T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065886 c.306C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065898 c.294C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065901 c.291A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065907 c.285G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065916 p.Phe92Tyr missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065925 c.267G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067325 c.621A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067331 c.615C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067334 c.612C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067340 c.606G>A synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067355 c.591A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.16 para-aminosalicylic_acid
thyX 3067771 p.Gly59Ser missense_variant 0.16 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067788 p.Lys53Arg missense_variant 0.18 para-aminosalicylic_acid
thyA 3073868 p.Thr202Ala missense_variant 1.0 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.18 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087672 p.His285Asp missense_variant 0.2 cycloserine
ald 3087699 p.Leu294Val missense_variant 0.19 cycloserine
ald 3087704 c.885T>C synonymous_variant 0.19 cycloserine
ald 3087716 c.897G>C synonymous_variant 0.21 cycloserine
ald 3087727 p.Ala303Gly missense_variant 0.2 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0 pyrazinamide Not assoc w R
lpqB 3623383 p.Ala510Pro missense_variant 0.16 rifampicin
bedaquiline
lpqB 3623393 p.Thr506Ser missense_variant 0.16 rifampicin
bedaquiline
lpqB 3623396 c.1515G>C synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624673 p.Ala80Ser missense_variant 0.26 rifampicin
bedaquiline
lpqB 3624675 p.Asn79Ser missense_variant 0.27 rifampicin
bedaquiline
lpqB 3624680 c.231T>G synonymous_variant 0.29 rifampicin
bedaquiline
lpqB 3624701 c.210T>G synonymous_variant 0.25 rifampicin
bedaquiline
lpqB 3624704 c.207G>C synonymous_variant 0.25 rifampicin
bedaquiline
lpqB 3624725 c.186G>T synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624734 c.177A>G synonymous_variant 0.18 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625690 c.-780T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3625711 c.903C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625753 p.Ala287Gln missense_variant 0.17 rifampicin
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625804 c.-896_-894delAGGinsCGC upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625822 c.-912C>T upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627032 c.-419G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627041 p.Ile103Val missense_variant 0.25 rifampicin
bedaquiline
mtrB 3627044 c.-431C>T upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627110 c.-497G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
alr 3840719 c.702A>G synonymous_variant 1.0 cycloserine
rpoA 3877587 c.921A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877590 c.918G>C synonymous_variant 0.22 rifampicin
rpoA 3877593 c.915C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.3 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.27 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.23 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.2 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.21 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.16 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.18 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.22 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877770 c.735_738delGTCAinsCAGC synonymous_variant 0.15 rifampicin
rpoA 3877782 c.726T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.16 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.48 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.47 rifampicin
rpoA 3877875 c.633T>A synonymous_variant 0.43 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.45 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.45 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.45 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.35 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.28 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>C synonymous_variant 0.25 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.36 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.42 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.4 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.44 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.4 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.41 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>A synonymous_variant 0.46 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.49 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878238 c.270C>T synonymous_variant 0.47 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.43 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.42 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.33 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.35 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.2 rifampicin Uncertain significance
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4038347 c.2358G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038383 c.2322G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.17 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.3 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.28 pyrazinamide
clpC1 4038533 p.Arg724Gln missense_variant 0.29 pyrazinamide
clpC1 4038536 c.2169C>G synonymous_variant 0.32 pyrazinamide
clpC1 4038551 c.2154C>G synonymous_variant 0.4 pyrazinamide
clpC1 4038563 c.2142C>T synonymous_variant 0.45 pyrazinamide
clpC1 4038584 c.2121G>A synonymous_variant 0.41 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.42 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.4 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.34 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.26 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.2 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.19 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.54 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.44 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.31 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.49 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039064 c.1641C>T synonymous_variant 0.39 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.25 pyrazinamide
clpC1 4039100 c.1605C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039118 c.1587C>A synonymous_variant 0.34 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.41 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.28 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039320 p.Ala462Gly missense_variant 0.15 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.44 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.35 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.34 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.37 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039688 c.1017G>A synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039694 c.1011G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039883 c.822G>A synonymous_variant 0.39 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.22 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039985 c.720G>A synonymous_variant 0.29 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040237 c.468C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.38 pyrazinamide
clpC1 4040258 c.447G>A synonymous_variant 0.5 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.41 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040306 c.399G>T synonymous_variant 0.28 pyrazinamide
clpC1 4040309 c.396C>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040324 c.381G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040495 c.210C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.39 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.37 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.2 pyrazinamide
clpC1 4040648 c.57G>A synonymous_variant 0.22 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.24 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040695 c.10C>A synonymous_variant 0.21 pyrazinamide
clpC1 4040696 c.9A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040699 c.6C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040711 c.-7G>A upstream_gene_variant 0.19 pyrazinamide
panD 4044714 c.-433T>C upstream_gene_variant 0.16 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.2 pyrazinamide
panD 4044746 c.-466_-465delTGinsCC upstream_gene_variant 0.17 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.17 pyrazinamide
panD 4044755 c.-474G>C upstream_gene_variant 0.18 pyrazinamide
panD 4044761 c.-480G>C upstream_gene_variant 0.18 pyrazinamide
glpK 4138703 c.1053C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138727 c.1029C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138747 c.1009C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139561 c.195G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139585 c.171G>A synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139594 c.162C>A synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139602 c.154C>A synonymous_variant 0.37 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240717 c.855T>C synonymous_variant 0.3 ethambutol
embC 4240777 c.915G>A synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.35 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.35 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.39 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.38 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.3 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.29 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.34 ethambutol
embC 4241039 p.Asp393Asn missense_variant 0.38 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.38 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.39 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.42 ethambutol
embC 4241059 c.1197G>A synonymous_variant 0.37 ethambutol
embC 4241074 c.1212G>C synonymous_variant 0.33 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.28 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.18 ethambutol
embC 4241109 p.Ala416Gly missense_variant 0.18 ethambutol
embC 4241539 c.1677T>C synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244681 c.1449A>C synonymous_variant 0.2 ethambutol
embA 4244684 c.1452C>G synonymous_variant 0.21 ethambutol
embA 4244695 p.Lys488Thr missense_variant 0.21 ethambutol
embA 4244712 p.Ala494Ser missense_variant 0.19 ethambutol Uncertain significance
embA 4244726 p.Asp498Glu missense_variant 0.17 ethambutol
embB 4247455 c.942C>T synonymous_variant 0.2 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.22 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.23 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.27 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.25 ethambutol
embB 4248233 c.1720C>T synonymous_variant 0.22 ethambutol
embB 4248242 p.Val577Ile missense_variant 0.31 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.28 ethambutol
embB 4248256 c.1743C>G synonymous_variant 0.25 ethambutol
embB 4248264 p.Phe584Cys missense_variant 0.3 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.32 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.25 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R