TB-Profiler

Lineage	Family	RDs	Frequency
lineage3	East-African-Indian	RD750	0.96

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1472307	n.462C>T	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance	Mutation from literature
embB	4247448	p.His312Arg	missense_variant	0.31	ethambutol		Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	571	c.571T>C	synonymous_variant	0.17	isoniazid
dnaA	582	c.582A>C	synonymous_variant	0.17	isoniazid	Not assoc w R - Interim
dnaA	609	c.609C>G	synonymous_variant	0.16	isoniazid
dnaA	610	c.610C>T	synonymous_variant	0.16	isoniazid
dnaA	630	c.630C>G	synonymous_variant	0.17	isoniazid
dnaA	882	c.882C>T	synonymous_variant	0.18	isoniazid
dnaA	885	c.885T>C	synonymous_variant	0.18	isoniazid
dnaA	897	c.897A>G	synonymous_variant	0.19	isoniazid
dnaA	909	c.909A>G	synonymous_variant	0.18	isoniazid
dnaA	912	c.912T>G	synonymous_variant	0.17	isoniazid
dnaA	921	c.921A>G	synonymous_variant	0.17	isoniazid	Not assoc w R - Interim
dnaA	927	c.927G>A	synonymous_variant	0.14	isoniazid
dnaA	1220	p.Asn407Ser	missense_variant	0.15	isoniazid
dnaA	1230	c.1230A>G	synonymous_variant	0.17	isoniazid
dnaA	1242	c.1242G>C	synonymous_variant	0.21	isoniazid
dnaA	1245	c.1245G>C	synonymous_variant	0.22	isoniazid	Not assoc w R - Interim
dnaA	1254	c.1254T>G	synonymous_variant	0.25	isoniazid
dnaA	1278	c.1278T>C	synonymous_variant	0.24	isoniazid
dnaA	1293	c.1293T>C	synonymous_variant	0.19	isoniazid
gyrB	6133	c.894G>A	synonymous_variant	0.14	levofloxacin
gyrB	6133	c.894G>A	synonymous_variant	0.14	moxifloxacin
gyrB	6319	c.1080G>C	synonymous_variant	0.15	levofloxacin	Not assoc w R - Interim
gyrB	6319	c.1080G>C	synonymous_variant	0.15	moxifloxacin
gyrA	6361	c.-941G>A	upstream_gene_variant	0.16	levofloxacin
gyrA	6361	c.-941G>A	upstream_gene_variant	0.16	moxifloxacin
gyrA	6362	c.-940T>C	upstream_gene_variant	0.16	levofloxacin
gyrA	6362	c.-940T>C	upstream_gene_variant	0.16	moxifloxacin
gyrA	6367	c.-935C>T	upstream_gene_variant	0.16	levofloxacin
gyrA	6367	c.-935C>T	upstream_gene_variant	0.16	moxifloxacin
gyrA	6376	c.-926G>A	upstream_gene_variant	0.15	levofloxacin
gyrA	6376	c.-926G>A	upstream_gene_variant	0.15	moxifloxacin
gyrA	6382	c.-920A>G	upstream_gene_variant	0.14	levofloxacin
gyrA	6382	c.-920A>G	upstream_gene_variant	0.14	moxifloxacin
gyrB	6745	c.1506T>C	synonymous_variant	0.19	levofloxacin	Not assoc w R - Interim
gyrB	6745	c.1506T>C	synonymous_variant	0.19	moxifloxacin	Not assoc w R - Interim
gyrA	6760	c.-542G>C	upstream_gene_variant	0.24	levofloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	0.24	moxifloxacin
gyrB	6775	c.1536G>C	synonymous_variant	0.26	levofloxacin	Not assoc w R - Interim
gyrB	6775	c.1536G>C	synonymous_variant	0.26	moxifloxacin	Not assoc w R - Interim
gyrA	6787	c.-515G>A	upstream_gene_variant	0.24	levofloxacin
gyrA	6787	c.-515G>A	upstream_gene_variant	0.24	moxifloxacin
gyrB	6793	c.1554T>C	synonymous_variant	0.23	levofloxacin	Not assoc w R - Interim
gyrB	6793	c.1554T>C	synonymous_variant	0.23	moxifloxacin	Not assoc w R - Interim
gyrB	6797	p.Gly520Thr	missense_variant	0.22	levofloxacin
gyrB	6797	p.Gly520Thr	missense_variant	0.22	moxifloxacin
gyrA	6838	c.-464C>T	upstream_gene_variant	0.22	levofloxacin
gyrA	6838	c.-464C>T	upstream_gene_variant	0.22	moxifloxacin
gyrB	6841	c.1602T>C	synonymous_variant	0.2	levofloxacin	Not assoc w R - Interim
gyrB	6841	c.1602T>C	synonymous_variant	0.2	moxifloxacin	Not assoc w R - Interim
gyrA	6853	c.-449A>G	upstream_gene_variant	0.16	levofloxacin
gyrA	6853	c.-449A>G	upstream_gene_variant	0.16	moxifloxacin
gyrB	6856	c.1617T>C	synonymous_variant	0.15	levofloxacin	Not assoc w R - Interim
gyrB	6856	c.1617T>C	synonymous_variant	0.15	moxifloxacin	Not assoc w R - Interim
gyrA	6866	c.-436C>T	upstream_gene_variant	0.15	levofloxacin
gyrA	6866	c.-436C>T	upstream_gene_variant	0.15	moxifloxacin
gyrB	6878	c.1639T>C	synonymous_variant	0.15	levofloxacin	Not assoc w R - Interim
gyrB	6878	c.1639T>C	synonymous_variant	0.15	moxifloxacin	Not assoc w R - Interim
gyrA	7165	c.-137C>G	upstream_gene_variant	0.21	levofloxacin
gyrA	7165	c.-137C>G	upstream_gene_variant	0.21	moxifloxacin
gyrA	7178	c.-124T>C	upstream_gene_variant	0.25	levofloxacin
gyrA	7178	c.-124T>C	upstream_gene_variant	0.25	moxifloxacin
gyrB	7216	c.1977G>C	synonymous_variant	0.2	levofloxacin	Not assoc w R - Interim
gyrB	7216	c.1977G>C	synonymous_variant	0.2	moxifloxacin
gyrA	7237	c.-65C>T	upstream_gene_variant	0.14	levofloxacin
gyrA	7237	c.-65C>T	upstream_gene_variant	0.14	moxifloxacin
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7391	c.90C>T	synonymous_variant	0.15	levofloxacin	Not assoc w R - Interim
gyrA	7391	c.90C>T	synonymous_variant	0.15	moxifloxacin	Not assoc w R - Interim
gyrA	7394	c.93T>C	synonymous_variant	0.17	levofloxacin	Not assoc w R - Interim
gyrA	7394	c.93T>C	synonymous_variant	0.17	moxifloxacin
gyrA	7427	c.126G>C	synonymous_variant	0.18	levofloxacin
gyrA	7427	c.126G>C	synonymous_variant	0.18	moxifloxacin
gyrA	7442	c.141G>T	synonymous_variant	0.21	levofloxacin
gyrA	7442	c.141G>T	synonymous_variant	0.21	moxifloxacin
gyrA	7451	c.150C>G	synonymous_variant	0.19	levofloxacin
gyrA	7451	c.150C>G	synonymous_variant	0.19	moxifloxacin
gyrA	7532	c.231T>C	synonymous_variant	0.15	levofloxacin	Not assoc w R - Interim
gyrA	7532	c.231T>C	synonymous_variant	0.15	moxifloxacin	Not assoc w R - Interim
gyrA	7538	c.237G>A	synonymous_variant	0.16	levofloxacin
gyrA	7538	c.237G>A	synonymous_variant	0.16	moxifloxacin
gyrA	7541	c.240C>G	synonymous_variant	0.16	levofloxacin	Not assoc w R - Interim
gyrA	7541	c.240C>G	synonymous_variant	0.16	moxifloxacin	Not assoc w R - Interim
gyrA	7547	c.246C>T	synonymous_variant	0.19	levofloxacin	Not assoc w R - Interim
gyrA	7547	c.246C>T	synonymous_variant	0.19	moxifloxacin	Not assoc w R - Interim
gyrA	7556	c.255C>T	synonymous_variant	0.19	levofloxacin	Not assoc w R - Interim
gyrA	7556	c.255C>T	synonymous_variant	0.19	moxifloxacin	Not assoc w R - Interim
gyrA	7559	c.258G>C	synonymous_variant	0.2	levofloxacin	Not assoc w R - Interim
gyrA	7559	c.258G>C	synonymous_variant	0.2	moxifloxacin	Not assoc w R - Interim
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7601	c.300C>G	synonymous_variant	0.15	levofloxacin	Not assoc w R - Interim
gyrA	7601	c.300C>G	synonymous_variant	0.15	moxifloxacin	Not assoc w R - Interim
gyrA	7607	c.306C>G	synonymous_variant	0.15	levofloxacin	Not assoc w R - Interim
gyrA	7607	c.306C>G	synonymous_variant	0.15	moxifloxacin	Not assoc w R - Interim
gyrA	7727	c.426G>C	synonymous_variant	0.19	levofloxacin
gyrA	7727	c.426G>C	synonymous_variant	0.19	moxifloxacin
gyrA	7728	c.427_429delAGGinsCGC	synonymous_variant	0.19	levofloxacin
gyrA	7728	c.427_429delAGGinsCGC	synonymous_variant	0.19	moxifloxacin
gyrA	7763	c.462T>C	synonymous_variant	0.3	levofloxacin	Not assoc w R - Interim
gyrA	7763	c.462T>C	synonymous_variant	0.3	moxifloxacin	Not assoc w R - Interim
gyrA	7769	c.468C>T	synonymous_variant	0.3	levofloxacin
gyrA	7769	c.468C>T	synonymous_variant	0.3	moxifloxacin
gyrA	7775	c.474C>T	synonymous_variant	0.27	levofloxacin	Not assoc w R - Interim
gyrA	7775	c.474C>T	synonymous_variant	0.27	moxifloxacin	Not assoc w R - Interim
gyrA	7778	c.477G>T	synonymous_variant	0.28	levofloxacin
gyrA	7778	c.477G>T	synonymous_variant	0.28	moxifloxacin
gyrA	7784	c.483A>G	synonymous_variant	0.26	levofloxacin
gyrA	7784	c.483A>G	synonymous_variant	0.26	moxifloxacin
gyrA	7787	c.486G>A	synonymous_variant	0.27	levofloxacin
gyrA	7787	c.486G>A	synonymous_variant	0.27	moxifloxacin
gyrA	7793	c.492G>C	synonymous_variant	0.28	levofloxacin
gyrA	7793	c.492G>C	synonymous_variant	0.28	moxifloxacin
gyrA	7799	c.498A>G	synonymous_variant	0.3	levofloxacin	Not assoc w R - Interim
gyrA	7799	c.498A>G	synonymous_variant	0.3	moxifloxacin	Not assoc w R - Interim
gyrA	7832	c.531G>T	synonymous_variant	0.26	levofloxacin
gyrA	7832	c.531G>T	synonymous_variant	0.26	moxifloxacin
gyrA	7835	c.534A>C	synonymous_variant	0.25	levofloxacin
gyrA	7835	c.534A>C	synonymous_variant	0.25	moxifloxacin
gyrA	7859	c.558A>G	synonymous_variant	0.19	levofloxacin
gyrA	7859	c.558A>G	synonymous_variant	0.19	moxifloxacin
gyrA	7865	c.564T>C	synonymous_variant	0.17	levofloxacin
gyrA	7865	c.564T>C	synonymous_variant	0.17	moxifloxacin
gyrA	7868	c.567C>T	synonymous_variant	0.16	levofloxacin
gyrA	7868	c.567C>T	synonymous_variant	0.16	moxifloxacin
gyrA	8120	c.819G>A	synonymous_variant	0.17	levofloxacin
gyrA	8120	c.819G>A	synonymous_variant	0.17	moxifloxacin
gyrA	8121	c.820T>C	synonymous_variant	0.17	levofloxacin
gyrA	8121	c.820T>C	synonymous_variant	0.17	moxifloxacin
gyrA	8129	c.828T>C	synonymous_variant	0.23	levofloxacin
gyrA	8129	c.828T>C	synonymous_variant	0.23	moxifloxacin
gyrA	8135	c.834C>G	synonymous_variant	0.26	levofloxacin
gyrA	8135	c.834C>G	synonymous_variant	0.26	moxifloxacin
gyrA	8156	c.855T>C	synonymous_variant	0.32	levofloxacin
gyrA	8156	c.855T>C	synonymous_variant	0.32	moxifloxacin
gyrA	8168	c.867A>G	synonymous_variant	0.3	levofloxacin
gyrA	8168	c.867A>G	synonymous_variant	0.3	moxifloxacin
gyrA	8177	c.876A>C	synonymous_variant	0.31	levofloxacin
gyrA	8177	c.876A>C	synonymous_variant	0.31	moxifloxacin
gyrA	8198	c.897T>C	synonymous_variant	0.25	levofloxacin	Not assoc w R - Interim
gyrA	8198	c.897T>C	synonymous_variant	0.25	moxifloxacin	Not assoc w R - Interim
gyrA	8207	c.906T>C	synonymous_variant	0.19	levofloxacin
gyrA	8207	c.906T>C	synonymous_variant	0.19	moxifloxacin
gyrA	8210	c.909G>A	synonymous_variant	0.19	levofloxacin
gyrA	8210	c.909G>A	synonymous_variant	0.19	moxifloxacin
gyrA	8219	c.918T>C	synonymous_variant	0.14	levofloxacin	Not assoc w R - Interim
gyrA	8219	c.918T>C	synonymous_variant	0.14	moxifloxacin	Not assoc w R - Interim
gyrA	8294	c.993T>C	synonymous_variant	0.16	levofloxacin	Not assoc w R - Interim
gyrA	8294	c.993T>C	synonymous_variant	0.16	moxifloxacin	Not assoc w R - Interim
gyrA	8324	c.1023T>C	synonymous_variant	0.18	levofloxacin
gyrA	8324	c.1023T>C	synonymous_variant	0.18	moxifloxacin
gyrA	8330	c.1029C>G	synonymous_variant	0.18	levofloxacin	Not assoc w R - Interim
gyrA	8330	c.1029C>G	synonymous_variant	0.18	moxifloxacin	Not assoc w R - Interim
gyrA	8340	p.Ala347Ser	missense_variant	0.13	levofloxacin	Uncertain significance
gyrA	8340	p.Ala347Ser	missense_variant	0.13	moxifloxacin	Uncertain significance
gyrA	8375	c.1074G>C	synonymous_variant	0.15	levofloxacin	Not assoc w R - Interim
gyrA	8375	c.1074G>C	synonymous_variant	0.15	moxifloxacin
gyrA	8382	p.Leu361Met	missense_variant	0.16	levofloxacin
gyrA	8382	p.Leu361Met	missense_variant	0.16	moxifloxacin
gyrA	8401	p.Asp367Ala	missense_variant	0.15	levofloxacin
gyrA	8401	p.Asp367Ala	missense_variant	0.15	moxifloxacin
gyrA	8420	c.1119T>C	synonymous_variant	0.18	levofloxacin
gyrA	8420	c.1119T>C	synonymous_variant	0.18	moxifloxacin
gyrA	8453	c.1152A>C	synonymous_variant	0.15	levofloxacin
gyrA	8453	c.1152A>C	synonymous_variant	0.15	moxifloxacin
gyrA	8546	p.Asp415Glu	missense_variant	0.22	levofloxacin
gyrA	8546	p.Asp415Glu	missense_variant	0.22	moxifloxacin
gyrA	8552	c.1251C>G	synonymous_variant	0.23	levofloxacin
gyrA	8552	c.1251C>G	synonymous_variant	0.23	moxifloxacin
gyrA	8561	c.1260A>C	synonymous_variant	0.26	levofloxacin	Not assoc w R - Interim
gyrA	8561	c.1260A>C	synonymous_variant	0.26	moxifloxacin	Not assoc w R - Interim
gyrA	8576	c.1275C>G	synonymous_variant	0.29	levofloxacin
gyrA	8576	c.1275C>G	synonymous_variant	0.29	moxifloxacin
gyrA	8603	c.1302A>G	synonymous_variant	0.3	levofloxacin	Not assoc w R - Interim
gyrA	8603	c.1302A>G	synonymous_variant	0.3	moxifloxacin	Not assoc w R - Interim
gyrA	8619	c.1318T>C	synonymous_variant	0.27	levofloxacin	Not assoc w R - Interim
gyrA	8619	c.1318T>C	synonymous_variant	0.27	moxifloxacin	Not assoc w R - Interim
gyrA	8624	c.1323G>C	synonymous_variant	0.26	levofloxacin
gyrA	8624	c.1323G>C	synonymous_variant	0.26	moxifloxacin
gyrA	8627	c.1326C>G	synonymous_variant	0.23	levofloxacin
gyrA	8627	c.1326C>G	synonymous_variant	0.23	moxifloxacin
gyrA	8636	c.1335A>C	synonymous_variant	0.22	levofloxacin	Not assoc w R - Interim
gyrA	8636	c.1335A>C	synonymous_variant	0.22	moxifloxacin	Not assoc w R - Interim
gyrA	8642	c.1341A>G	synonymous_variant	0.2	levofloxacin
gyrA	8642	c.1341A>G	synonymous_variant	0.2	moxifloxacin
gyrA	8655	p.Ile452Val	missense_variant	0.18	levofloxacin
gyrA	8655	p.Ile452Val	missense_variant	0.18	moxifloxacin
gyrA	8767	p.Arg489Lys	missense_variant	0.15	levofloxacin	Uncertain significance
gyrA	8767	p.Arg489Lys	missense_variant	0.15	moxifloxacin	Uncertain significance
gyrA	8780	p.Asp493Glu	missense_variant	0.2	levofloxacin
gyrA	8780	p.Asp493Glu	missense_variant	0.2	moxifloxacin
gyrA	8783	c.1482G>T	synonymous_variant	0.21	levofloxacin
gyrA	8783	c.1482G>T	synonymous_variant	0.21	moxifloxacin
gyrA	8810	c.1509A>T	synonymous_variant	0.22	levofloxacin	Not assoc w R - Interim
gyrA	8810	c.1509A>T	synonymous_variant	0.22	moxifloxacin	Not assoc w R - Interim
gyrA	8817	p.Ser506Ala	missense_variant	0.21	levofloxacin
gyrA	8817	p.Ser506Ala	missense_variant	0.21	moxifloxacin
gyrA	8828	c.1527T>C	synonymous_variant	0.23	levofloxacin
gyrA	8828	c.1527T>C	synonymous_variant	0.23	moxifloxacin
gyrA	8829	c.1528T>C	synonymous_variant	0.22	levofloxacin	Not assoc w R - Interim
gyrA	8829	c.1528T>C	synonymous_variant	0.22	moxifloxacin	Not assoc w R - Interim
gyrA	8843	c.1542G>A	synonymous_variant	0.16	levofloxacin	Not assoc w R - Interim
gyrA	8843	c.1542G>A	synonymous_variant	0.16	moxifloxacin	Not assoc w R - Interim
gyrA	8897	c.1596T>C	synonymous_variant	0.15	levofloxacin	Not assoc w R - Interim
gyrA	8897	c.1596T>C	synonymous_variant	0.15	moxifloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.16	levofloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.16	moxifloxacin	Not assoc w R - Interim
gyrA	8915	c.1614A>G	synonymous_variant	0.19	levofloxacin	Not assoc w R - Interim
gyrA	8915	c.1614A>G	synonymous_variant	0.19	moxifloxacin	Not assoc w R - Interim
gyrA	8933	c.1632G>C	synonymous_variant	0.24	levofloxacin
gyrA	8933	c.1632G>C	synonymous_variant	0.24	moxifloxacin
gyrA	8939	c.1638T>C	synonymous_variant	0.25	levofloxacin
gyrA	8939	c.1638T>C	synonymous_variant	0.25	moxifloxacin
gyrA	8942	c.1641G>C	synonymous_variant	0.25	levofloxacin
gyrA	8942	c.1641G>C	synonymous_variant	0.25	moxifloxacin
gyrA	8966	c.1665C>G	synonymous_variant	0.27	levofloxacin	Not assoc w R - Interim
gyrA	8966	c.1665C>G	synonymous_variant	0.27	moxifloxacin	Not assoc w R - Interim
gyrA	8967	p.Ala556Arg	missense_variant	0.27	levofloxacin
gyrA	8967	p.Ala556Arg	missense_variant	0.27	moxifloxacin
gyrA	8990	c.1689C>G	synonymous_variant	0.29	levofloxacin
gyrA	8990	c.1689C>G	synonymous_variant	0.29	moxifloxacin
gyrA	8998	p.Leu566Trp	missense_variant	0.3	levofloxacin	Uncertain significance
gyrA	8998	p.Leu566Trp	missense_variant	0.3	moxifloxacin	Uncertain significance
gyrA	9002	c.1701C>T	synonymous_variant	0.3	levofloxacin
gyrA	9002	c.1701C>T	synonymous_variant	0.3	moxifloxacin
gyrA	9017	c.1716C>G	synonymous_variant	0.27	levofloxacin	Not assoc w R - Interim
gyrA	9017	c.1716C>G	synonymous_variant	0.27	moxifloxacin	Not assoc w R - Interim
gyrA	9023	c.1722A>C	synonymous_variant	0.25	levofloxacin	Not assoc w R - Interim
gyrA	9023	c.1722A>C	synonymous_variant	0.25	moxifloxacin	Not assoc w R - Interim
gyrA	9029	c.1728T>G	synonymous_variant	0.26	levofloxacin
gyrA	9029	c.1728T>G	synonymous_variant	0.26	moxifloxacin
gyrA	9051	c.1750T>C	synonymous_variant	0.19	levofloxacin
gyrA	9051	c.1750T>C	synonymous_variant	0.19	moxifloxacin
gyrA	9056	c.1755C>G	synonymous_variant	0.19	levofloxacin	Not assoc w R - Interim
gyrA	9056	c.1755C>G	synonymous_variant	0.19	moxifloxacin	Not assoc w R - Interim
gyrA	9065	c.1764C>G	synonymous_variant	0.17	levofloxacin
gyrA	9065	c.1764C>G	synonymous_variant	0.17	moxifloxacin
gyrA	9071	c.1770G>C	synonymous_variant	0.15	levofloxacin
gyrA	9071	c.1770G>C	synonymous_variant	0.15	moxifloxacin
gyrA	9267	p.Asn656Gly	missense_variant	0.19	levofloxacin
gyrA	9267	p.Asn656Gly	missense_variant	0.19	moxifloxacin
gyrA	9296	c.1995T>C	synonymous_variant	0.28	levofloxacin	Not assoc w R - Interim
gyrA	9296	c.1995T>C	synonymous_variant	0.28	moxifloxacin	Not assoc w R - Interim
gyrA	9299	c.1998G>C	synonymous_variant	0.27	levofloxacin	Not assoc w R - Interim
gyrA	9299	c.1998G>C	synonymous_variant	0.27	moxifloxacin	Not assoc w R - Interim
gyrA	9304	p.Gly668Glu	missense_variant	1.0	levofloxacin
gyrA	9304	p.Gly668Glu	missense_variant	1.0	moxifloxacin
gyrA	9335	c.2034G>C	synonymous_variant	0.39	levofloxacin
gyrA	9335	c.2034G>C	synonymous_variant	0.39	moxifloxacin
gyrA	9345	c.2044A>C	synonymous_variant	0.39	levofloxacin
gyrA	9345	c.2044A>C	synonymous_variant	0.39	moxifloxacin
gyrA	9365	c.2064G>A	synonymous_variant	0.3	levofloxacin
gyrA	9365	c.2064G>A	synonymous_variant	0.3	moxifloxacin
gyrA	9377	c.2076A>G	synonymous_variant	0.25	levofloxacin	Not assoc w R - Interim
gyrA	9377	c.2076A>G	synonymous_variant	0.25	moxifloxacin	Not assoc w R - Interim
gyrA	9383	c.2082T>C	synonymous_variant	0.23	levofloxacin
gyrA	9383	c.2082T>C	synonymous_variant	0.23	moxifloxacin
gyrA	9395	c.2094G>C	synonymous_variant	0.19	levofloxacin	Not assoc w R - Interim
gyrA	9395	c.2094G>C	synonymous_variant	0.19	moxifloxacin	Not assoc w R - Interim
gyrA	9398	c.2097T>C	synonymous_variant	0.18	levofloxacin
gyrA	9398	c.2097T>C	synonymous_variant	0.18	moxifloxacin
fgd1	490812	c.30A>G	synonymous_variant	0.16	pretomanid
					delamanid
					clofazimine
fgd1	490815	c.33G>C	synonymous_variant	0.15	pretomanid
					delamanid
					clofazimine
fgd1	490818	c.36C>T	synonymous_variant	0.17	pretomanid
					delamanid
					clofazimine
fgd1	490827	c.45C>T	synonymous_variant	0.21	pretomanid
					delamanid
					clofazimine
fgd1	490851	c.69A>C	synonymous_variant	0.22	pretomanid
					delamanid
					clofazimine
fgd1	490854	c.72C>T	synonymous_variant	0.22	pretomanid
					delamanid
					clofazimine
fgd1	490868	p.Ala29Gly	missense_variant	0.17	pretomanid
					delamanid
					clofazimine
fgd1	490872	c.90C>T	synonymous_variant	0.17	pretomanid
					delamanid
					clofazimine
fgd1	490887	c.105G>A	synonymous_variant	0.22	pretomanid
					delamanid
					clofazimine
fgd1	490902	c.120T>C	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fgd1	490905	c.123T>C	synonymous_variant	0.14	pretomanid
					delamanid
					clofazimine
fgd1	490998	c.216T>C	synonymous_variant	0.22	pretomanid
					delamanid
					clofazimine
fgd1	491007	c.225G>C	synonymous_variant	0.26	pretomanid
					delamanid
					clofazimine
fgd1	491013	c.231C>G	synonymous_variant	0.22	pretomanid
					delamanid
					clofazimine
fgd1	491034	c.252C>G	synonymous_variant	0.19	pretomanid
					delamanid
					clofazimine
fgd1	491043	c.261T>G	synonymous_variant	0.17	pretomanid
					delamanid
					clofazimine
fgd1	491560	p.His260Thr	missense_variant	0.17	pretomanid
					delamanid
					clofazimine
fgd1	491569	p.Asp263His	missense_variant	0.19	pretomanid
					delamanid
					clofazimine
fgd1	491578	p.Ile266Arg	missense_variant	0.2	pretomanid
					delamanid
					clofazimine
fgd1	491601	c.819T>C	synonymous_variant	0.19	pretomanid
					delamanid
					clofazimine
fgd1	491742	c.960T>C	synonymous_variant	0.99	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R
mshA	574900	c.-448G>C	upstream_gene_variant	1.0	isoniazid	Uncertain significance
mshA	574900	c.-448G>C	upstream_gene_variant	1.0	ethionamide	Uncertain significance
mshA	575561	p.Met72Val	missense_variant	0.19	isoniazid
mshA	575561	p.Met72Val	missense_variant	0.19	ethionamide
mshA	575569	c.222A>G	synonymous_variant	0.17	isoniazid
mshA	575569	c.222A>G	synonymous_variant	0.17	ethionamide
mshA	575571	p.Ser75Thr	missense_variant	0.17	isoniazid
mshA	575571	p.Ser75Thr	missense_variant	0.17	ethionamide
mshA	575614	c.267C>T	synonymous_variant	0.13	isoniazid
mshA	575614	c.267C>T	synonymous_variant	0.13	ethionamide
mshA	575785	c.438T>C	synonymous_variant	0.15	isoniazid
mshA	575785	c.438T>C	synonymous_variant	0.15	ethionamide
mshA	575821	c.474G>C	synonymous_variant	0.22	isoniazid
mshA	575821	c.474G>C	synonymous_variant	0.22	ethionamide
mshA	575824	c.477T>G	synonymous_variant	0.21	isoniazid
mshA	575824	c.477T>G	synonymous_variant	0.21	ethionamide
mshA	575833	c.486C>T	synonymous_variant	0.27	isoniazid	Not assoc w R - Interim
mshA	575833	c.486C>T	synonymous_variant	0.27	ethionamide	Not assoc w R - Interim
mshA	575845	c.498C>G	synonymous_variant	0.29	isoniazid
mshA	575845	c.498C>G	synonymous_variant	0.29	ethionamide
mshA	575878	c.531A>C	synonymous_variant	0.26	isoniazid
mshA	575878	c.531A>C	synonymous_variant	0.26	ethionamide
mshA	575887	c.540G>C	synonymous_variant	0.26	isoniazid
mshA	575887	c.540G>C	synonymous_variant	0.26	ethionamide
mshA	575938	c.591G>C	synonymous_variant	0.16	isoniazid
mshA	575938	c.591G>C	synonymous_variant	0.16	ethionamide
mshA	575944	c.597T>C	synonymous_variant	0.17	isoniazid
mshA	575944	c.597T>C	synonymous_variant	0.17	ethionamide
mshA	575953	c.606G>C	synonymous_variant	0.17	isoniazid
mshA	575953	c.606G>C	synonymous_variant	0.17	ethionamide
ccsA	619574	c.-317G>A	upstream_gene_variant	0.19	kanamycin
					capreomycin
					amikacin
ccsA	619579	c.-312G>C	upstream_gene_variant	0.2	kanamycin
					capreomycin
					amikacin
ccsA	619591	c.-300G>C	upstream_gene_variant	0.22	kanamycin
					capreomycin
					amikacin
ccsA	619594	c.-297G>C	upstream_gene_variant	0.21	kanamycin
					capreomycin
					amikacin
ccsA	619618	c.-273C>G	upstream_gene_variant	0.25	kanamycin
					capreomycin
					amikacin
ccsA	619634	c.-257T>A	upstream_gene_variant	0.25	kanamycin
					capreomycin
					amikacin
ccsA	619645	c.-246G>C	upstream_gene_variant	0.22	kanamycin
					capreomycin
					amikacin
ccsA	619654	c.-237A>G	upstream_gene_variant	0.18	kanamycin
					capreomycin
					amikacin
ccsA	620784	c.894C>A	synonymous_variant	0.14	kanamycin
					capreomycin
					amikacin
ccsA	620790	c.900C>T	synonymous_variant	0.14	kanamycin
					capreomycin
					amikacin
Rv0565c	656502	c.969C>T	synonymous_variant	0.16	ethionamide
Rv0565c	656511	c.960T>C	synonymous_variant	0.17	ethionamide	Not assoc w R - Interim
Rv0565c	656568	c.903G>C	synonymous_variant	0.18	ethionamide
Rv0565c	657081	c.390G>A	synonymous_variant	1.0	ethionamide	Not assoc w R - Interim
Rv0565c	657653	c.-183C>G	upstream_gene_variant	0.16	ethionamide
Rv0565c	657671	c.-201A>G	upstream_gene_variant	0.21	ethionamide
Rv0565c	657678	c.-209_-208delAAinsTC	upstream_gene_variant	0.23	ethionamide
Rv0565c	657689	c.-220_-219delCAinsAC	upstream_gene_variant	0.2	ethionamide
Rv0565c	657701	c.-231C>G	upstream_gene_variant	0.16	ethionamide
Rv0565c	657734	c.-264T>C	upstream_gene_variant	0.21	ethionamide
hadA	731747	c.-183T>C	upstream_gene_variant	0.18	isoniazid
hadA	731774	c.-156T>C	upstream_gene_variant	0.23	isoniazid
hadA	731789	c.-141A>G	upstream_gene_variant	0.24	isoniazid
hadA	731792	c.-138G>A	upstream_gene_variant	0.24	isoniazid
hadA	731801	c.-129C>G	upstream_gene_variant	0.23	isoniazid
hadA	731816	c.-114G>A	upstream_gene_variant	0.22	isoniazid
hadA	731840	c.-90G>C	upstream_gene_variant	0.15	isoniazid
hadA	731843	c.-87T>C	upstream_gene_variant	0.16	isoniazid
hadA	731849	c.-81C>T	upstream_gene_variant	0.16	isoniazid
hadA	732378	c.450_452dupAGA	disruptive_inframe_insertion	0.33	isoniazid
hadA	732389	p.Ser154Thr	missense_variant	0.32	isoniazid
hadA	732396	p.Gly156Ala	missense_variant	0.31	isoniazid
hadA	732398	p.Ala157Thr	missense_variant	0.29	isoniazid
nusG	734147	c.-107T>C	upstream_gene_variant	0.14	rifampicin
nusG	734370	c.117A>G	synonymous_variant	0.22	rifampicin
nusG	734407	p.Val52Ile	missense_variant	0.26	rifampicin
nusG	734421	c.168A>G	synonymous_variant	0.3	rifampicin
nusG	734424	c.171G>C	synonymous_variant	0.26	rifampicin
nusG	734442	c.189G>A	synonymous_variant	0.29	rifampicin
nusG	734451	c.198G>C	synonymous_variant	0.27	rifampicin
nusG	734460	c.207G>T	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
nusG	734472	c.219T>C	synonymous_variant	0.27	rifampicin
nusG	734475	c.222T>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
nusG	734532	c.279A>G	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
nusG	734538	c.285C>T	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
nusG	734541	c.288A>G	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
nusG	734556	c.303C>T	synonymous_variant	0.28	rifampicin
nusG	734559	c.306T>C	synonymous_variant	0.28	rifampicin
nusG	734580	c.327T>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
nusG	734589	c.336G>C	synonymous_variant	0.23	rifampicin
nusG	734750	p.Ser166Thr	missense_variant	0.16	rifampicin
nusG	734754	c.501G>C	synonymous_variant	0.18	rifampicin
nusG	734757	c.504T>C	synonymous_variant	0.19	rifampicin
nusG	734771	p.Ala173Val	missense_variant	0.24	rifampicin
nusG	734781	c.528A>G	synonymous_variant	0.27	rifampicin
nusG	734792	p.Val180Ala	missense_variant	0.26	rifampicin
nusG	734794	p.Val181Ile	missense_variant	0.26	rifampicin	Uncertain significance
nusG	734814	c.561G>C	synonymous_variant	0.25	rifampicin
nusG	734826	c.573A>G	synonymous_variant	0.25	rifampicin
nusG	734829	c.576C>G	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
nusG	734841	c.588G>C	synonymous_variant	0.16	rifampicin
nusG	734865	c.612G>C	synonymous_variant	0.15	rifampicin
rpoB	760067	c.261G>C	synonymous_variant	0.2	rifampicin
rpoB	760070	c.264T>G	synonymous_variant	0.2	rifampicin
rpoB	760091	c.285G>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	760101	c.295T>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoB	760112	c.306T>C	synonymous_variant	0.28	rifampicin
rpoB	760118	c.312T>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoB	760130	p.Asp108Glu	missense_variant	0.27	rifampicin	Uncertain significance
rpoB	760139	c.333A>G	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoB	760142	c.336C>G	synonymous_variant	0.24	rifampicin
rpoB	760181	c.375T>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoB	760184	c.378A>G	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoB	760196	c.390C>G	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoB	760223	c.417T>C	synonymous_variant	0.21	rifampicin
rpoB	760235	c.429T>C	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
rpoB	760244	c.438G>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	760256	c.450C>T	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	760274	c.468G>A	synonymous_variant	0.22	rifampicin
rpoB	760283	c.477G>C	synonymous_variant	0.22	rifampicin	Not assoc w R - Interim
rpoB	760328	c.522G>C	synonymous_variant	0.22	rifampicin
rpoB	760331	c.525G>C	synonymous_variant	0.22	rifampicin
rpoB	760337	c.531C>G	synonymous_variant	0.2	rifampicin
rpoB	760340	c.534G>C	synonymous_variant	0.2	rifampicin
rpoB	760361	c.555T>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	760370	c.564C>G	synonymous_variant	0.23	rifampicin
rpoB	760376	p.Asp190Glu	missense_variant	0.22	rifampicin	Uncertain significance
rpoB	760380	p.Thr192Leu	missense_variant	0.21	rifampicin
rpoB	760424	c.618C>G	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
rpoB	760430	c.624T>C	synonymous_variant	0.2	rifampicin	Not assoc w R - Interim
rpoB	760475	c.669A>G	synonymous_variant	0.2	rifampicin	Not assoc w R - Interim
rpoB	760481	c.675G>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	760484	c.678A>G	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoB	760520	c.714C>G	synonymous_variant	0.32	rifampicin
rpoB	760522	p.Ser239Asn	missense_variant	0.34	rifampicin	Uncertain significance
rpoB	760532	c.726T>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	760533	p.Val243Thr	missense_variant	0.3	rifampicin
rpoB	760547	c.741G>T	synonymous_variant	0.34	rifampicin
rpoB	760563	p.Arg253Met	missense_variant	0.27	rifampicin	Uncertain significance
rpoB	760591	p.Val262Ala	missense_variant	0.28	rifampicin
rpoB	760598	c.792C>T	synonymous_variant	0.25	rifampicin
rpoB	760611	c.805T>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	760646	c.840C>G	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	760655	c.849A>G	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoB	760661	c.855A>G	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	760670	c.864G>C	synonymous_variant	0.21	rifampicin
rpoB	760674	c.868T>C	synonymous_variant	0.2	rifampicin	Not assoc w R - Interim
rpoB	760679	c.873A>G	synonymous_variant	0.2	rifampicin	Not assoc w R - Interim
rpoB	760683	c.877T>C	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
rpoB	760724	c.918T>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	760730	c.924T>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	760751	c.945G>C	synonymous_variant	0.26	rifampicin
rpoB	760755	p.His317Asn	missense_variant	0.26	rifampicin
rpoB	760765	p.Glu320Ala	missense_variant	0.27	rifampicin
rpoB	760769	c.963C>G	synonymous_variant	0.26	rifampicin
rpoB	760793	c.987A>G	synonymous_variant	0.22	rifampicin
rpoB	760805	c.999G>C	synonymous_variant	0.22	rifampicin
rpoB	760817	c.1011A>G	synonymous_variant	0.24	rifampicin
rpoB	760820	c.1014T>C	synonymous_variant	0.2	rifampicin
rpoB	760830	c.1024T>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	760841	c.1035T>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoB	760845	p.Thr347Ala	missense_variant	0.27	rifampicin
rpoB	760856	c.1050C>G	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	760859	c.1053T>C	synonymous_variant	0.23	rifampicin
rpoB	760862	c.1056G>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	760869	p.Val355Thr	missense_variant	0.26	rifampicin
rpoB	760886	c.1080A>G	synonymous_variant	0.26	rifampicin
rpoB	760919	c.1113C>G	synonymous_variant	0.31	rifampicin
rpoB	760925	c.1119T>C	synonymous_variant	0.29	rifampicin
rpoB	760928	c.1122G>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	760931	c.1125C>G	synonymous_variant	0.3	rifampicin
rpoB	760946	c.1140A>G	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoB	760982	c.1176G>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	760991	c.1185G>T	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoB	761006	c.1200C>G	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoB	761015	c.1209G>C	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoB	761021	c.1215G>C	synonymous_variant	0.3	rifampicin
rpoB	761027	c.1221A>G	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoB	761036	c.1230G>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	761037	c.1231T>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	761057	c.1251G>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	761097	c.1291_1293delAGCinsTCG	synonymous_variant	0.27	rifampicin
rpoB	761102	c.1296A>G	synonymous_variant	0.29	rifampicin
rpoB	761129	c.1323G>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	761133	c.1327_1329delTTGinsCTC	synonymous_variant	0.26	rifampicin
rpoB	761147	c.1341C>T	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoB	761150	c.1344A>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	761165	c.1359G>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	761180	c.1374A>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	761189	c.1383T>C	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoB	761195	c.1389G>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	761207	c.1401C>T	synonymous_variant	0.31	rifampicin
rpoB	761234	c.1428G>C	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoB	761249	c.1443A>G	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	761255	c.1449T>G	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoB	761261	c.1455G>T	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	761264	c.1458C>G	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoB	761300	c.1494G>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoB	761318	c.1512G>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	761327	c.1521A>G	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoB	761345	c.1539G>C	synonymous_variant	0.21	rifampicin
rpoB	761354	c.1548C>T	synonymous_variant	0.18	rifampicin
rpoB	761492	c.1686G>C	synonymous_variant	0.22	rifampicin
rpoB	761504	c.1698C>G	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	761510	c.1704T>C	synonymous_variant	0.25	rifampicin
rpoB	761531	c.1725C>G	synonymous_variant	0.28	rifampicin
rpoB	761537	c.1731C>G	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	761561	c.1755C>G	synonymous_variant	0.25	rifampicin
rpoB	761564	c.1758G>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	761570	c.1764T>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoB	761573	c.1767C>G	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	761579	c.1773G>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	761606	c.1800C>G	synonymous_variant	0.31	rifampicin
rpoB	761612	c.1806G>T	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoB	761615	c.1809A>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	761636	c.1830G>T	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoB	761645	c.1839C>G	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoB	761648	c.1842T>C	synonymous_variant	0.31	rifampicin
rpoB	761657	c.1851C>G	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoB	761669	c.1863C>T	synonymous_variant	0.24	rifampicin
rpoB	761675	c.1869G>C	synonymous_variant	0.21	rifampicin
rpoB	761765	c.1959T>C	synonymous_variant	0.19	rifampicin
rpoB	761772	p.His656Ala	missense_variant	0.18	rifampicin
rpoB	761778	p.Asn658Asp	missense_variant	0.18	rifampicin
rpoB	761791	p.Arg662His	missense_variant	0.22	rifampicin
rpoB	761813	c.2007T>C	synonymous_variant	0.19	rifampicin
rpoB	761815	p.Ala670Glu	missense_variant	0.17	rifampicin
rpoB	761834	c.2028T>C	synonymous_variant	0.16	rifampicin
rpoB	761885	c.2079T>C	synonymous_variant	0.19	rifampicin
rpoB	761891	c.2085G>C	synonymous_variant	0.21	rifampicin
rpoB	761909	c.2103T>C	synonymous_variant	0.19	rifampicin
rpoB	761912	c.2106T>C	synonymous_variant	0.17	rifampicin
rpoB	761915	p.Asp703Glu	missense_variant	0.17	rifampicin
rpoB	761916	p.Asp704Asn	missense_variant	0.16	rifampicin
rpoB	761921	c.2115C>T	synonymous_variant	0.2	rifampicin
rpoB	761948	c.2142G>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	761954	c.2148C>G	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	761969	c.2163G>A	synonymous_variant	0.22	rifampicin	Not assoc w R - Interim
rpoB	761972	c.2166C>G	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoB	761999	c.2193G>C	synonymous_variant	0.29	rifampicin
rpoB	762008	c.2202C>G	synonymous_variant	0.3	rifampicin
rpoB	762014	c.2208C>T	synonymous_variant	0.3	rifampicin
rpoB	762017	c.2211A>G	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	762053	c.2247T>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	762062	c.2256T>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	762065	c.2259T>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	762083	c.2277T>C	synonymous_variant	0.22	rifampicin	Not assoc w R - Interim
rpoB	762086	c.2280G>C	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
rpoB	762101	c.2295C>G	synonymous_variant	0.22	rifampicin	Not assoc w R - Interim
rpoB	762114	p.Ile770Val	missense_variant	0.2	rifampicin	Uncertain significance
rpoB	762131	c.2325C>G	synonymous_variant	0.21	rifampicin
rpoB	762143	c.2337T>C	synonymous_variant	0.22	rifampicin
rpoB	762149	c.2343G>C	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
rpoB	762176	c.2370T>C	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoB	762185	c.2379G>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoB	762233	c.2427G>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	762254	c.2448T>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoB	762257	c.2451C>G	synonymous_variant	0.27	rifampicin
rpoB	762284	c.2478G>T	synonymous_variant	0.35	rifampicin
rpoB	762293	c.2487T>C	synonymous_variant	0.34	rifampicin	Not assoc w R - Interim
rpoB	762296	c.2490G>C	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoB	762317	c.2511A>G	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoB	762329	c.2523G>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	762338	c.2532T>C	synonymous_variant	0.27	rifampicin
rpoB	762347	c.2541T>C	synonymous_variant	0.28	rifampicin
rpoB	762356	c.2550G>A	synonymous_variant	0.27	rifampicin
rpoB	762362	p.Glu852Asp	missense_variant	0.28	rifampicin
rpoB	762369	c.2563T>C	synonymous_variant	0.27	rifampicin
rpoC	762398	c.-972T>C	upstream_gene_variant	0.25	rifampicin
rpoC	762401	c.-969G>C	upstream_gene_variant	0.23	rifampicin
rpoB	762404	c.2598T>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	762410	c.-960T>C	upstream_gene_variant	0.26	rifampicin
rpoB	762416	c.2610A>G	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoB	762434	c.2628T>G	synonymous_variant	0.71	rifampicin	Not assoc w R
rpoC	762443	c.-927G>C	upstream_gene_variant	0.25	rifampicin
rpoB	762449	c.2643C>A	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoB	762452	c.2646G>C	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoB	762470	c.2664G>C	synonymous_variant	0.2	rifampicin	Not assoc w R - Interim
rpoB	762489	p.Val895Gln	missense_variant	0.18	rifampicin
rpoC	762509	c.-861T>G	upstream_gene_variant	0.18	rifampicin
rpoB	762510	p.Ala902Pro	missense_variant	0.18	rifampicin	Uncertain significance
rpoC	762533	c.-837T>C	upstream_gene_variant	0.23	rifampicin
rpoC	762536	c.-834T>C	upstream_gene_variant	0.23	rifampicin
rpoC	762537	c.-833T>C	upstream_gene_variant	0.23	rifampicin
rpoC	762545	c.-825C>G	upstream_gene_variant	0.24	rifampicin
rpoC	762551	c.-819C>T	upstream_gene_variant	0.21	rifampicin
rpoB	762729	p.Gln975Lys	missense_variant	0.15	rifampicin
rpoB	762736	p.Ala977Glu	missense_variant	0.17	rifampicin
rpoB	762750	p.Leu982Met	missense_variant	0.17	rifampicin
rpoB	762753	c.2947T>C	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoC	762758	c.-612G>C	upstream_gene_variant	0.22	rifampicin
rpoB	762785	p.Asp993Glu	missense_variant	0.23	rifampicin	Uncertain significance
rpoB	762788	c.2982G>C	synonymous_variant	0.18	rifampicin	Not assoc w R - Interim
rpoB	762789	p.Leu995Met	missense_variant	0.18	rifampicin	Uncertain significance
rpoB	762795	p.Asp997Asn	missense_variant	0.21	rifampicin	Uncertain significance
rpoB	762799	p.Ala998Gly	missense_variant	0.23	rifampicin	Uncertain significance
rpoB	762812	c.3006C>G	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	762813	p.Met1003Val	missense_variant	0.27	rifampicin
rpoB	762818	c.3012C>G	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	762827	c.3021G>C	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoB	762833	c.3027C>T	synonymous_variant	0.37	rifampicin	Not assoc w R - Interim
rpoB	762857	c.3051C>G	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoB	762860	c.3054G>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoC	762863	c.-507T>G	upstream_gene_variant	0.27	rifampicin
rpoB	762899	c.3093G>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>T	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoC	762947	c.-423C>G	upstream_gene_variant	0.27	rifampicin
rpoB	762962	c.3156C>T	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	762983	c.-387C>T	upstream_gene_variant	0.21	rifampicin
rpoC	762989	c.-381G>C	upstream_gene_variant	0.21	rifampicin
rpoB	762995	c.3189G>T	synonymous_variant	0.22	rifampicin	Not assoc w R - Interim
rpoB	763028	c.3222T>C	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoB	763031	c.3225T>C	synonymous_variant	1.0	rifampicin	Not assoc w R
rpoB	763034	c.3228C>G	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoB	763040	c.3234C>G	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
rpoB	763070	c.3264T>C	synonymous_variant	0.22	rifampicin	Not assoc w R - Interim
rpoB	763085	c.3279C>G	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoB	763115	c.3309T>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoC	763139	c.-231C>T	upstream_gene_variant	0.29	rifampicin
rpoC	763148	c.-222G>C	upstream_gene_variant	0.31	rifampicin
rpoC	763158	c.-212C>T	upstream_gene_variant	0.26	rifampicin
rpoB	763166	c.3360A>G	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoC	763202	c.-168A>C	upstream_gene_variant	0.17	rifampicin
rpoC	763205	c.-165G>C	upstream_gene_variant	0.16	rifampicin
rpoC	763206	c.-164_-162delAGTinsTCG	upstream_gene_variant	0.16	rifampicin
rpoC	763226	c.-144A>G	upstream_gene_variant	0.19	rifampicin
rpoB	763238	c.3432T>C	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoC	763253	c.-117G>C	upstream_gene_variant	0.17	rifampicin
rpoC	763402	c.33C>T	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	763408	c.39T>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoC	763411	c.42T>G	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	763414	c.45T>C	synonymous_variant	0.25	rifampicin
rpoC	763441	c.72C>T	synonymous_variant	0.2	rifampicin
rpoC	763444	c.75T>C	synonymous_variant	0.2	rifampicin	Not assoc w R - Interim
rpoC	763456	c.87A>G	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
rpoC	763486	c.117T>G	synonymous_variant	0.26	rifampicin
rpoC	763528	c.159G>A	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoC	763546	c.177A>G	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoC	763570	c.201G>C	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	763573	c.204G>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoC	763576	c.207C>G	synonymous_variant	0.25	rifampicin
rpoC	763594	c.225C>T	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	763603	c.234C>T	synonymous_variant	0.22	rifampicin	Not assoc w R - Interim
rpoC	763636	c.267T>C	synonymous_variant	0.27	rifampicin
rpoC	763660	c.291T>G	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoC	763663	c.294C>G	synonymous_variant	0.26	rifampicin
rpoC	763675	c.306C>G	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoC	763696	c.327T>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoC	763702	c.333C>G	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoC	763714	c.345G>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoC	763717	c.348T>C	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoC	763723	c.354G>C	synonymous_variant	0.3	rifampicin
rpoC	763732	c.363C>G	synonymous_variant	0.34	rifampicin
rpoC	763741	c.372C>T	synonymous_variant	0.38	rifampicin
rpoC	763744	c.375G>C	synonymous_variant	0.38	rifampicin
rpoC	763765	c.396T>C	synonymous_variant	0.38	rifampicin
rpoC	763774	c.405G>C	synonymous_variant	0.38	rifampicin
rpoC	763792	p.Glu141Asp	missense_variant	0.33	rifampicin
rpoC	763801	c.432C>T	synonymous_variant	0.28	rifampicin
rpoC	763807	c.438T>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoC	763816	c.447C>G	synonymous_variant	0.24	rifampicin
rpoC	763858	c.489A>G	synonymous_variant	0.15	rifampicin
rpoC	763872	p.Gly168Ala	missense_variant	0.26	rifampicin
rpoC	763876	p.Glu169Asp	missense_variant	0.28	rifampicin
rpoC	763879	c.510A>G	synonymous_variant	0.3	rifampicin
rpoC	763891	c.522G>C	synonymous_variant	0.31	rifampicin
rpoC	763894	c.525A>G	synonymous_variant	0.31	rifampicin
rpoC	763900	c.531G>C	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoC	763930	c.561G>A	synonymous_variant	0.42	rifampicin
rpoC	763945	c.576T>C	synonymous_variant	0.38	rifampicin
rpoC	763951	c.582G>C	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoC	763960	c.591T>C	synonymous_variant	0.34	rifampicin	Not assoc w R - Interim
rpoC	763987	c.618C>T	synonymous_variant	0.25	rifampicin
rpoC	763991	p.Ile208Leu	missense_variant	0.21	rifampicin
rpoC	763996	c.627T>C	synonymous_variant	0.18	rifampicin
rpoC	764002	c.633C>G	synonymous_variant	0.19	rifampicin
rpoC	764005	c.636G>C	synonymous_variant	0.2	rifampicin	Not assoc w R - Interim
rpoC	764011	c.642T>C	synonymous_variant	0.21	rifampicin
rpoC	764059	c.690G>T	synonymous_variant	0.17	rifampicin
rpoC	764083	c.714A>G	synonymous_variant	0.25	rifampicin
rpoC	764098	c.729A>G	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoC	764101	c.732C>G	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoC	764102	p.Val245Ile	missense_variant	0.24	rifampicin
rpoC	764112	p.Tyr248Phe	missense_variant	0.32	rifampicin
rpoC	764116	c.747C>T	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoC	764131	c.762T>C	synonymous_variant	0.34	rifampicin
rpoC	764134	c.765C>G	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoC	764198	c.829C>T	synonymous_variant	0.28	rifampicin
rpoC	764203	c.834G>T	synonymous_variant	0.27	rifampicin
rpoC	764206	c.837T>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoC	764213	p.Arg282Lys	missense_variant	0.26	rifampicin	Uncertain significance
rpoC	764257	c.888G>C	synonymous_variant	0.39	rifampicin
rpoC	764266	c.897T>C	synonymous_variant	0.36	rifampicin
rpoC	764269	c.900G>C	synonymous_variant	0.36	rifampicin
rpoC	764278	c.909A>G	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoC	764287	c.918C>T	synonymous_variant	0.43	rifampicin
rpoC	764293	c.924G>C	synonymous_variant	0.45	rifampicin	Not assoc w R - Interim
rpoC	764338	c.969G>A	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoC	764365	c.996C>T	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoC	764380	c.1011G>C	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoC	764383	c.1014C>G	synonymous_variant	0.27	rifampicin
rpoC	764387	c.1018_1020delTTGinsCTC	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoC	764405	c.1036_1038delAGGinsCGC	synonymous_variant	0.22	rifampicin	Not assoc w R - Interim
rpoC	764428	c.1059G>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoC	764431	c.1062G>C	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoC	764434	c.1065A>G	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	764446	c.1077T>C	synonymous_variant	0.27	rifampicin
rpoC	764449	c.1080G>C	synonymous_variant	0.26	rifampicin
rpoC	764452	c.1083T>C	synonymous_variant	0.25	rifampicin
rpoC	764458	c.1089G>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoC	764461	c.1092A>G	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoC	764497	c.1128A>G	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoC	764500	c.1131C>G	synonymous_variant	0.34	rifampicin
rpoC	764521	c.1152T>C	synonymous_variant	0.34	rifampicin	Not assoc w R - Interim
rpoC	764527	c.1158C>T	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoC	764536	c.1167G>C	synonymous_variant	0.36	rifampicin
rpoC	764539	c.1170C>G	synonymous_variant	0.34	rifampicin	Not assoc w R - Interim
rpoC	764548	c.1179G>A	synonymous_variant	0.33	rifampicin
rpoC	764554	c.1185C>T	synonymous_variant	0.31	rifampicin
rpoC	764560	c.1191T>C	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoC	764566	c.1197C>G	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoC	764575	c.1206T>C	synonymous_variant	0.23	rifampicin
rpoC	764581	c.1212T>C	synonymous_variant	0.24	rifampicin
rpoC	764593	c.1224C>T	synonymous_variant	0.25	rifampicin
rpoC	764611	c.1242G>C	synonymous_variant	0.3	rifampicin
rpoC	764626	c.1257C>T	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoC	764650	c.1281G>T	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoC	764668	c.1299C>T	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoC	764764	c.1395T>C	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoC	764803	c.1434C>T	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoC	764809	c.1440C>T	synonymous_variant	0.32	rifampicin	Not assoc w R
rpoC	764815	c.1446A>G	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoC	764827	c.1458G>C	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoC	764858	c.1489T>C	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoC	764872	c.1503A>G	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoC	764888	c.1519T>C	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
rpoC	764932	c.1563C>G	synonymous_variant	0.31	rifampicin
rpoC	764935	c.1566T>C	synonymous_variant	0.32	rifampicin
rpoC	764948	c.1579T>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoC	764968	c.1599T>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoC	764995	c.1626C>G	synonymous_variant	0.23	rifampicin	Not assoc w R
rpoC	765007	c.1638T>G	synonymous_variant	0.17	rifampicin	Not assoc w R - Interim
rpoC	765008	c.1639T>C	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
rpoC	765055	c.1686C>G	synonymous_variant	0.15	rifampicin	Not assoc w R - Interim
rpoC	765103	c.1734G>T	synonymous_variant	0.15	rifampicin
rpoC	765244	c.1875T>C	synonymous_variant	0.16	rifampicin
rpoC	765247	c.1878C>G	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
rpoC	765248	c.1879T>C	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
rpoC	765251	c.1882_1884delAGCinsTCG	synonymous_variant	0.16	rifampicin
rpoC	765287	c.1918C>T	synonymous_variant	0.21	rifampicin
rpoC	765292	c.1923G>T	synonymous_variant	0.17	rifampicin
rpoC	765300	p.Val644Ala	missense_variant	0.23	rifampicin	Uncertain significance
rpoC	765319	c.1950A>G	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	765326	p.His653Ala	missense_variant	0.25	rifampicin	Uncertain significance
rpoC	765330	p.Ser654Asn	missense_variant	0.26	rifampicin	Uncertain significance
rpoC	765370	c.2001G>T	synonymous_variant	0.2	rifampicin
rpoC	765371	c.2002C>T	synonymous_variant	0.2	rifampicin
rpoC	765379	c.2010G>T	synonymous_variant	0.18	rifampicin
rpoC	765383	p.Met672Leu	missense_variant	0.18	rifampicin	Uncertain significance
rpoC	765394	c.2025G>A	synonymous_variant	0.17	rifampicin
rpoC	765404	p.Leu679Val	missense_variant	0.14	rifampicin
rpoC	765409	c.2040T>C	synonymous_variant	0.16	rifampicin
rpoC	765412	c.2043T>C	synonymous_variant	0.17	rifampicin
rpoC	765421	c.2052C>G	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoC	765451	c.2082C>G	synonymous_variant	0.24	rifampicin
rpoC	765454	c.2085C>G	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoC	765469	c.2100G>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoC	765478	c.2109T>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoC	765499	c.2130C>G	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoC	765508	c.2139C>G	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoC	765529	c.2160C>T	synonymous_variant	0.23	rifampicin
rpoC	765541	c.2172C>G	synonymous_variant	0.2	rifampicin
rpoC	765553	c.2184C>T	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
rpoC	765556	c.2187G>C	synonymous_variant	0.15	rifampicin
rpoC	765562	c.2193G>C	synonymous_variant	0.17	rifampicin
rpoC	765580	c.2211G>C	synonymous_variant	0.17	rifampicin
rpoC	765583	c.2214G>C	synonymous_variant	0.16	rifampicin
rpoC	765613	p.His748Gln	missense_variant	0.25	rifampicin
rpoC	765625	c.2256C>G	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoC	765628	c.2259G>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoC	765631	p.Asp754Glu	missense_variant	0.27	rifampicin
rpoC	765658	c.2289C>T	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoC	765700	c.2331T>C	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoC	765734	c.2365T>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoC	765739	c.2370G>T	synonymous_variant	0.24	rifampicin
rpoC	765751	c.2382C>G	synonymous_variant	0.21	rifampicin
rpoC	765753	p.Asp795Ala	missense_variant	0.2	rifampicin	Uncertain significance
rpoC	765772	c.2403C>G	synonymous_variant	0.19	rifampicin
rpoC	765778	c.2409C>G	synonymous_variant	0.22	rifampicin
rpoC	765784	c.2415C>G	synonymous_variant	0.23	rifampicin
rpoC	765793	c.2424C>G	synonymous_variant	0.21	rifampicin
rpoC	765796	c.2427C>T	synonymous_variant	0.21	rifampicin
rpoC	765811	c.2442T>G	synonymous_variant	0.23	rifampicin
rpoC	765826	c.2457T>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoC	765886	c.2517C>G	synonymous_variant	0.31	rifampicin
rpoC	765928	c.2559C>G	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	765967	c.2598C>T	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoC	766010	p.Ser881Thr	missense_variant	0.14	rifampicin
rpoC	766021	c.2652G>C	synonymous_variant	0.16	rifampicin
rpoC	766027	c.2658G>C	synonymous_variant	0.17	rifampicin
rpoC	766043	p.Gln892Glu	missense_variant	0.23	rifampicin
rpoC	766054	c.2685C>G	synonymous_variant	0.26	rifampicin
rpoC	766061	p.Val898Ile	missense_variant	0.26	rifampicin
rpoC	766080	c.2712_2715delTGCA	frameshift_variant	0.18	rifampicin
rpoC	766096	c.2727G>C	synonymous_variant	0.2	rifampicin
rpoC	766097	p.Leu910Val	missense_variant	0.2	rifampicin
rpoC	766288	c.2919C>T	synonymous_variant	0.15	rifampicin
rpoC	766294	c.2925C>T	synonymous_variant	0.16	rifampicin
rpoC	766303	c.2934C>T	synonymous_variant	0.18	rifampicin	Not assoc w R - Interim
rpoC	766315	c.2946C>G	synonymous_variant	0.2	rifampicin
rpoC	766321	c.2952C>G	synonymous_variant	0.19	rifampicin
rpoC	766327	c.2958C>G	synonymous_variant	0.19	rifampicin
rpoC	766345	c.2976T>C	synonymous_variant	0.16	rifampicin
rpoC	766357	c.2988C>T	synonymous_variant	0.17	rifampicin
rpoC	766369	c.3000C>G	synonymous_variant	0.16	rifampicin
rpoC	766381	c.3012C>T	synonymous_variant	0.17	rifampicin
rpoC	766384	c.3015A>G	synonymous_variant	0.18	rifampicin
rpoC	766390	c.3021C>T	synonymous_variant	0.22	rifampicin
rpoC	766408	c.3039C>T	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoC	766411	c.3042C>G	synonymous_variant	0.29	rifampicin
rpoC	766426	c.3057C>T	synonymous_variant	0.32	rifampicin
rpoC	766447	c.3078T>C	synonymous_variant	0.36	rifampicin
rpoC	766462	c.3093G>T	synonymous_variant	0.33	rifampicin
rpoC	766483	c.3114G>C	synonymous_variant	0.23	rifampicin
rpoC	766484	p.Val1039Ile	missense_variant	0.23	rifampicin	Uncertain significance
rpoC	766492	c.3123T>C	synonymous_variant	0.24	rifampicin
rpoC	766495	c.3126C>T	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoC	766522	c.3153C>G	synonymous_variant	0.24	rifampicin
rpoC	766531	c.3162G>T	synonymous_variant	0.21	rifampicin
rpoC	766543	c.3174C>T	synonymous_variant	0.24	rifampicin
rpoC	766573	c.3204T>C	synonymous_variant	0.21	rifampicin
rpoC	766583	p.Gly1072Ser	missense_variant	0.19	rifampicin
rpoC	766591	c.3222A>G	synonymous_variant	0.17	rifampicin
rpoC	766594	c.3225G>C	synonymous_variant	0.17	rifampicin
rpoC	766597	c.3228C>G	synonymous_variant	0.18	rifampicin	Not assoc w R - Interim
rpoC	766607	p.Ile1080Leu	missense_variant	0.23	rifampicin
rpoC	766630	c.3261G>T	synonymous_variant	0.25	rifampicin
rpoC	766645	c.3276A>G	synonymous_variant	0.32	rifampicin
rpoC	766657	c.3288A>G	synonymous_variant	0.3	rifampicin
rpoC	766666	c.3297C>G	synonymous_variant	0.3	rifampicin
rpoC	766672	c.3303T>C	synonymous_variant	0.33	rifampicin
rpoC	766726	c.3357T>C	synonymous_variant	0.35	rifampicin
rpoC	766738	c.3369G>C	synonymous_variant	0.36	rifampicin
rpoC	766765	c.3396A>C	synonymous_variant	0.34	rifampicin	Not assoc w R - Interim
rpoC	766774	c.3405T>C	synonymous_variant	0.35	rifampicin
rpoC	766804	c.3435A>G	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
rpoC	766861	c.3492G>C	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoC	766864	c.3495G>C	synonymous_variant	0.29	rifampicin
rpoC	766867	c.3498C>G	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoC	766894	c.3525T>C	synonymous_variant	0.28	rifampicin
rpoC	766895	c.3526T>C	synonymous_variant	0.28	rifampicin
rpoC	766900	c.3531T>C	synonymous_variant	0.29	rifampicin
rpoC	766918	c.3549C>G	synonymous_variant	0.25	rifampicin
rpoC	766921	c.3552G>C	synonymous_variant	0.25	rifampicin
rpoC	766924	p.Glu1185Asp	missense_variant	0.27	rifampicin
rpoC	766933	c.3564A>G	synonymous_variant	0.28	rifampicin
rpoC	766945	c.3576A>G	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	767059	c.3690T>G	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoC	767062	c.3693C>A	synonymous_variant	0.24	rifampicin
rpoC	767098	c.3729T>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoC	767104	c.3735C>G	synonymous_variant	0.22	rifampicin	Not assoc w R - Interim
rpoC	767105	p.Asn1246Gln	missense_variant	0.21	rifampicin	Uncertain significance
rpoC	767119	c.3750A>G	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoC	767134	c.3765C>A	synonymous_variant	0.24	rifampicin
rpoC	767167	c.3798C>G	synonymous_variant	0.15	rifampicin	Not assoc w R - Interim
rpoC	767180	p.Ala1271Gln	missense_variant	0.16	rifampicin
rpoC	767191	c.3822C>G	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
rpoC	767206	c.3837C>G	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoC	767209	c.3840T>C	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoC	767212	c.3843G>C	synonymous_variant	0.2	rifampicin
rpoC	767221	c.3852C>G	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoC	767230	c.3861G>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoC	767233	c.3864T>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoC	767263	c.3894T>C	synonymous_variant	0.17	rifampicin	Not assoc w R - Interim
rpoC	767264	p.Ala1299Gln	missense_variant	0.16	rifampicin
rpoC	767281	c.3912C>G	synonymous_variant	0.15	rifampicin	Not assoc w R - Interim
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	clofazimine	Not assoc w R
rpsL	781230	c.-330T>C	upstream_gene_variant	0.16	streptomycin
rpsL	781234	c.-326G>C	upstream_gene_variant	0.16	streptomycin
rpsL	781240	c.-320A>T	upstream_gene_variant	0.16	streptomycin
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
rpsL	781595	c.36T>C	synonymous_variant	0.15	streptomycin
rpsL	781598	c.39G>C	synonymous_variant	0.16	streptomycin
rpsL	781628	c.69T>C	synonymous_variant	0.2	streptomycin	Not assoc w R - Interim
rpsL	781634	c.75G>A	synonymous_variant	0.2	streptomycin
rpsL	781649	c.90T>C	synonymous_variant	0.19	streptomycin
rpsL	781655	c.96T>C	synonymous_variant	0.17	streptomycin
rpsL	781682	c.123T>C	synonymous_variant	0.25	streptomycin
rpsL	781715	c.156T>C	synonymous_variant	0.26	streptomycin
rpsL	781718	c.159C>T	synonymous_variant	0.26	streptomycin
rpsL	781728	c.169T>C	synonymous_variant	0.28	streptomycin
rpsL	781736	c.177T>C	synonymous_variant	0.28	streptomycin
rpsL	781742	c.183C>T	synonymous_variant	0.3	streptomycin
rpsL	781751	c.192G>C	synonymous_variant	0.32	streptomycin
rpsL	781754	c.195G>C	synonymous_variant	0.33	streptomycin
rpsL	781814	c.255C>T	synonymous_variant	0.29	streptomycin
rpsL	781817	c.258G>T	synonymous_variant	0.3	streptomycin
rpsL	781832	c.273T>C	synonymous_variant	0.25	streptomycin
rpsL	781838	c.279G>C	synonymous_variant	0.21	streptomycin
rpsL	781841	c.282C>G	synonymous_variant	0.21	streptomycin
rpsL	781898	c.339A>T	synonymous_variant	0.25	streptomycin
rpsL	781916	c.357T>C	synonymous_variant	0.28	streptomycin
rpsL	781929	p.Gly124Ser	missense_variant	0.32	streptomycin	Uncertain significance
rplC	800516	c.-293G>T	upstream_gene_variant	0.19	linezolid
rplC	800537	c.-272C>T	upstream_gene_variant	0.27	linezolid
rplC	800546	c.-263T>G	upstream_gene_variant	0.26	linezolid
rplC	800567	c.-242A>G	upstream_gene_variant	0.29	linezolid
rplC	800582	c.-227C>G	upstream_gene_variant	0.27	linezolid
rplC	800591	c.-218C>T	upstream_gene_variant	0.23	linezolid
rplC	800600	c.-209G>T	upstream_gene_variant	0.22	linezolid
rplC	800612	c.-197A>G	upstream_gene_variant	0.21	linezolid
rplC	800654	c.-155T>C	upstream_gene_variant	0.17	linezolid
rplC	800693	c.-116A>G	upstream_gene_variant	0.18	linezolid
rplC	801171	c.363A>G	synonymous_variant	0.2	linezolid
rplC	801174	c.366T>C	synonymous_variant	0.2	linezolid
rplC	801195	c.387G>C	synonymous_variant	0.24	linezolid
rplC	801207	c.399C>T	synonymous_variant	0.24	linezolid
rplC	801210	c.402T>C	synonymous_variant	0.24	linezolid
rplC	801222	c.414T>C	synonymous_variant	0.22	linezolid
rplC	801249	c.441T>C	synonymous_variant	0.16	linezolid
rplC	801255	c.447C>T	synonymous_variant	0.15	linezolid
rplC	801367	p.Ala187Thr	missense_variant	0.14	linezolid
rplC	801396	c.588T>C	synonymous_variant	0.18	linezolid
rplC	801399	c.591G>C	synonymous_variant	0.19	linezolid
rplC	801402	c.594T>C	synonymous_variant	0.19	linezolid
rplC	801405	c.597T>C	synonymous_variant	0.19	linezolid
rplC	801423	c.615G>C	synonymous_variant	0.15	linezolid
Rv1129c	1253541	p.Ile332Leu	missense_variant	1.0	levofloxacin
					moxifloxacin
					isoniazid	Uncertain significance
					rifampicin	Uncertain significance
Rv1129c	1254562	c.-28T>C	upstream_gene_variant	1.0	levofloxacin	Not assoc w R
					moxifloxacin	Not assoc w R
					isoniazid	Not assoc w R
					rifampicin	Not assoc w R
Rv1129c	1254591	c.-57C>T	upstream_gene_variant	1.0	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
fbiC	1303492	c.562T>C	synonymous_variant	0.16	pretomanid
					delamanid
					clofazimine
fbiC	1303509	c.579G>C	synonymous_variant	0.2	pretomanid
					delamanid
					clofazimine
fbiC	1303512	c.582T>C	synonymous_variant	0.2	pretomanid
					delamanid
					clofazimine
fbiC	1303534	p.Ser202Ala	missense_variant	0.2	pretomanid
					delamanid
					clofazimine
fbiC	1303545	c.615A>G	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fbiC	1303674	c.744C>G	synonymous_variant	0.15	pretomanid
					delamanid
					clofazimine
fbiC	1303686	c.756C>G	synonymous_variant	0.17	pretomanid
					delamanid
					clofazimine
fbiC	1303695	c.765T>C	synonymous_variant	0.2	pretomanid
					delamanid
					clofazimine
fbiC	1303704	c.774T>C	synonymous_variant	0.23	pretomanid
					delamanid
					clofazimine
fbiC	1303708	c.778T>C	synonymous_variant	0.23	pretomanid
					delamanid
					clofazimine
fbiC	1303728	c.798G>C	synonymous_variant	0.22	pretomanid
					delamanid
					clofazimine
fbiC	1303731	c.801A>C	synonymous_variant	0.2	pretomanid
					delamanid
					clofazimine
fbiC	1303732	p.Ser268Thr	missense_variant	0.2	pretomanid
					delamanid
					clofazimine
fbiC	1303746	c.816T>C	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fbiC	1303749	c.819G>C	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fbiC	1303752	c.822A>G	synonymous_variant	0.18	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
fbiC	1303755	c.825T>C	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fbiC	1303785	c.855G>T	synonymous_variant	0.15	pretomanid
					delamanid
					clofazimine
fbiC	1303818	c.888C>G	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fbiC	1303846	p.Phe306Val	missense_variant	0.19	pretomanid
					delamanid
					clofazimine
fbiC	1303854	c.924T>C	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fbiC	1303860	c.930A>C	synonymous_variant	0.19	pretomanid
					delamanid
					clofazimine
fbiC	1303884	c.954T>G	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fbiC	1303890	c.960G>C	synonymous_variant	0.16	pretomanid
					delamanid
					clofazimine
fbiC	1304568	c.1638T>C	synonymous_variant	0.15	pretomanid
					delamanid
					clofazimine
fbiC	1304574	c.1644C>G	synonymous_variant	0.15	pretomanid
					delamanid
					clofazimine
fbiC	1304613	c.1683T>G	synonymous_variant	0.15	pretomanid
					delamanid
					clofazimine
fbiC	1304625	c.1695C>T	synonymous_variant	0.14	pretomanid
					delamanid
					clofazimine
fbiC	1304742	c.1812T>C	synonymous_variant	0.16	pretomanid
					delamanid
					clofazimine
fbiC	1304748	c.1818T>C	synonymous_variant	0.19	pretomanid
					delamanid
					clofazimine
fbiC	1304757	c.1827A>G	synonymous_variant	0.2	pretomanid
					delamanid
					clofazimine
fbiC	1304778	c.1848T>C	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fbiC	1304784	c.1854T>C	synonymous_variant	0.19	pretomanid
					delamanid
					clofazimine
fbiC	1304787	c.1857T>G	synonymous_variant	0.19	pretomanid
					delamanid
					clofazimine
fbiC	1304790	c.1860C>G	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fbiC	1304796	c.1866G>A	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fbiC	1304808	c.1878C>G	synonymous_variant	0.19	pretomanid
					delamanid
					clofazimine
fbiC	1304811	c.1881C>G	synonymous_variant	0.19	pretomanid
					delamanid
					clofazimine
fbiC	1304817	c.1887T>C	synonymous_variant	0.2	pretomanid
					delamanid
					clofazimine
fbiC	1304853	c.1923C>T	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fbiC	1304856	c.1926C>G	synonymous_variant	0.17	pretomanid
					delamanid
					clofazimine
fbiC	1304869	c.1939C>T	synonymous_variant	0.17	pretomanid
					delamanid
					clofazimine
fbiC	1304880	c.1950C>T	synonymous_variant	0.17	pretomanid
					delamanid
					clofazimine
fbiC	1304955	c.2025G>A	synonymous_variant	0.14	pretomanid
					delamanid
					clofazimine
fbiC	1304958	c.2028T>G	synonymous_variant	0.16	pretomanid
					delamanid
					clofazimine
fbiC	1304994	c.2064A>G	synonymous_variant	0.19	pretomanid
					delamanid
					clofazimine
fbiC	1304995	c.2065T>C	synonymous_variant	0.2	pretomanid
					delamanid
					clofazimine
fbiC	1305012	c.2082G>C	synonymous_variant	0.19	pretomanid
					delamanid
					clofazimine
fbiC	1305014	p.Thr695Ser	missense_variant	0.19	pretomanid
					delamanid
					clofazimine
fbiC	1305021	c.2091C>A	synonymous_variant	0.21	pretomanid
					delamanid
					clofazimine
fbiC	1305033	c.2103T>G	synonymous_variant	0.22	pretomanid
					delamanid
					clofazimine
fbiC	1305039	c.2109G>C	synonymous_variant	0.23	pretomanid
					delamanid
					clofazimine
fbiC	1305042	c.2112A>G	synonymous_variant	0.21	pretomanid
					delamanid
					clofazimine
fbiC	1305045	c.2115A>G	synonymous_variant	0.22	pretomanid
					delamanid
					clofazimine
fbiC	1305066	c.2136T>C	synonymous_variant	0.18	pretomanid
					delamanid
					clofazimine
fbiC	1305069	c.2139G>C	synonymous_variant	0.17	pretomanid
					delamanid
					clofazimine
fbiC	1305075	c.2145T>C	synonymous_variant	0.15	pretomanid
					delamanid
					clofazimine
fbiC	1305078	c.2148A>G	synonymous_variant	0.15	pretomanid
					delamanid
					clofazimine
fbiC	1305114	c.2184T>C	synonymous_variant	0.15	pretomanid
					delamanid
					clofazimine
fbiC	1305117	c.2187T>C	synonymous_variant	0.15	pretomanid
					delamanid
					clofazimine
fbiC	1305126	c.2196T>C	synonymous_variant	0.15	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
atpE	1461219	c.175T>C	synonymous_variant	0.16	bedaquiline
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471934	n.89A>G	non_coding_transcript_exon_variant	0.14	kanamycin
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472044	n.199G>T	non_coding_transcript_exon_variant	0.14	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472053	n.211_212delGC	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472061	n.216A>T	non_coding_transcript_exon_variant	0.18	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472075	n.230A>G	non_coding_transcript_exon_variant	0.18	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472108	n.263C>T	non_coding_transcript_exon_variant	0.17	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472857	n.1012A>G	non_coding_transcript_exon_variant	0.71	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.27	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473105	n.1260G>A	non_coding_transcript_exon_variant	0.26	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1473123	n.1278delAinsTT	non_coding_transcript_exon_variant	0.24	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.23	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.25	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473288	n.1443C>T	non_coding_transcript_exon_variant	0.16	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	0.15	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1473291	n.1446G>T	non_coding_transcript_exon_variant	0.15	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrl	1473668	n.11C>T	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1473668	n.11C>T	non_coding_transcript_exon_variant	0.14	linezolid
rrl	1473756	n.99G>A	non_coding_transcript_exon_variant	0.23	capreomycin
rrl	1473756	n.99G>A	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	0.26	capreomycin	Uncertain significance
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	0.26	linezolid	Uncertain significance
rrl	1473813	n.156C>T	non_coding_transcript_exon_variant	0.28	capreomycin
rrl	1473813	n.156C>T	non_coding_transcript_exon_variant	0.28	linezolid
rrl	1473839	n.182G>T	non_coding_transcript_exon_variant	0.27	capreomycin
rrl	1473839	n.182G>T	non_coding_transcript_exon_variant	0.27	linezolid
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	0.21	capreomycin
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1473899	n.242A>C	non_coding_transcript_exon_variant	0.18	capreomycin	Uncertain significance
rrl	1473899	n.242A>C	non_coding_transcript_exon_variant	0.18	linezolid	Uncertain significance
rrl	1473936	n.279A>G	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1473936	n.279A>G	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1473943	n.286G>T	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1473943	n.286G>T	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1473944	n.287G>A	non_coding_transcript_exon_variant	0.17	capreomycin
rrl	1473944	n.287G>A	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1473945	n.288T>C	non_coding_transcript_exon_variant	0.16	capreomycin
rrl	1473945	n.288T>C	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1473966	n.309T>C	non_coding_transcript_exon_variant	0.19	capreomycin
rrl	1473966	n.309T>C	non_coding_transcript_exon_variant	0.19	linezolid
rrl	1473971	n.314G>T	non_coding_transcript_exon_variant	0.17	capreomycin
rrl	1473971	n.314G>T	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	0.21	capreomycin	Not assoc w R
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	0.21	linezolid	Not assoc w R
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	0.23	capreomycin
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1474012	n.355C>T	non_coding_transcript_exon_variant	0.21	capreomycin
rrl	1474012	n.355C>T	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1474036	n.379G>A	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1474036	n.379G>A	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1474054	n.397T>C	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1474054	n.397T>C	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1474093	n.436G>T	non_coding_transcript_exon_variant	0.23	capreomycin
rrl	1474093	n.436G>T	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1474099	n.442G>A	non_coding_transcript_exon_variant	0.25	capreomycin
rrl	1474099	n.442G>A	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	0.24	capreomycin
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	0.24	linezolid
rrl	1474111	n.454T>C	non_coding_transcript_exon_variant	0.26	capreomycin
rrl	1474111	n.454T>C	non_coding_transcript_exon_variant	0.26	linezolid
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	0.31	capreomycin	Uncertain significance
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	0.31	linezolid	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	0.36	capreomycin	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	0.36	linezolid	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	0.35	linezolid
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	0.18	capreomycin	Uncertain significance
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	0.18	linezolid	Uncertain significance
rrl	1474639	n.982G>A	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1474639	n.982G>A	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.27	linezolid	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.27	linezolid	Uncertain significance
rrl	1474823	n.1166C>T	non_coding_transcript_exon_variant	0.27	capreomycin
rrl	1474823	n.1166C>T	non_coding_transcript_exon_variant	0.27	linezolid
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	0.33	linezolid
rrl	1474904	n.1247G>A	non_coding_transcript_exon_variant	0.27	capreomycin
rrl	1474904	n.1247G>A	non_coding_transcript_exon_variant	0.27	linezolid
rrl	1474956	n.1299C>T	non_coding_transcript_exon_variant	0.23	capreomycin
rrl	1474956	n.1299C>T	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1474960	n.1303C>G	non_coding_transcript_exon_variant	0.22	capreomycin
rrl	1474960	n.1303C>G	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1474963	n.1306G>T	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1474963	n.1306G>T	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1474964	n.1307T>A	non_coding_transcript_exon_variant	0.22	capreomycin
rrl	1474964	n.1307T>A	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1474965	n.1308G>C	non_coding_transcript_exon_variant	0.23	capreomycin
rrl	1474965	n.1308G>C	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1474970	n.1313G>A	non_coding_transcript_exon_variant	0.23	capreomycin
rrl	1474970	n.1313G>A	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1475006	n.1349A>T	non_coding_transcript_exon_variant	0.29	capreomycin
rrl	1475006	n.1349A>T	non_coding_transcript_exon_variant	0.29	linezolid
rrl	1475013	n.1356G>A	non_coding_transcript_exon_variant	0.25	capreomycin
rrl	1475013	n.1356G>A	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1475028	n.1371G>A	non_coding_transcript_exon_variant	0.19	capreomycin
rrl	1475028	n.1371G>A	non_coding_transcript_exon_variant	0.19	linezolid
rrl	1475061	n.1404C>T	non_coding_transcript_exon_variant	0.18	capreomycin	Uncertain significance
rrl	1475061	n.1404C>T	non_coding_transcript_exon_variant	0.18	linezolid
rrl	1475088	n.1431A>T	non_coding_transcript_exon_variant	0.18	capreomycin
rrl	1475088	n.1431A>T	non_coding_transcript_exon_variant	0.18	linezolid
rrl	1475199	n.1542G>A	non_coding_transcript_exon_variant	0.24	capreomycin
rrl	1475199	n.1542G>A	non_coding_transcript_exon_variant	0.24	linezolid
rrl	1475201	n.1544G>A	non_coding_transcript_exon_variant	0.22	capreomycin
rrl	1475201	n.1544G>A	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1475206	n.1549C>T	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1475206	n.1549C>T	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1475209	n.1552G>C	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1475209	n.1552G>C	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1475213	n.1556C>T	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1475213	n.1556C>T	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1475249	n.1592T>C	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1475249	n.1592T>C	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1475252	n.1595C>T	non_coding_transcript_exon_variant	0.28	capreomycin
rrl	1475252	n.1595C>T	non_coding_transcript_exon_variant	0.28	linezolid
rrl	1475266	n.1609T>C	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1475266	n.1609T>C	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1475267	n.1610G>A	non_coding_transcript_exon_variant	0.24	capreomycin
rrl	1475267	n.1610G>A	non_coding_transcript_exon_variant	0.24	linezolid
rrl	1475275	n.1618C>T	non_coding_transcript_exon_variant	0.26	capreomycin
rrl	1475275	n.1618C>T	non_coding_transcript_exon_variant	0.26	linezolid
rrl	1475276	n.1619T>C	non_coding_transcript_exon_variant	0.26	capreomycin
rrl	1475276	n.1619T>C	non_coding_transcript_exon_variant	0.26	linezolid
rrl	1475291	n.1634A>C	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1475291	n.1634A>C	non_coding_transcript_exon_variant	0.33	linezolid	Uncertain significance
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.3	capreomycin
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.3	linezolid
rrl	1475402	n.1745C>T	non_coding_transcript_exon_variant	0.29	capreomycin
rrl	1475402	n.1745C>T	non_coding_transcript_exon_variant	0.29	linezolid
rrl	1475409	n.1752T>C	non_coding_transcript_exon_variant	0.27	capreomycin
rrl	1475409	n.1752T>C	non_coding_transcript_exon_variant	0.27	linezolid
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.28	linezolid
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.31	capreomycin	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.31	linezolid
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.31	capreomycin	Uncertain significance
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.31	linezolid	Uncertain significance
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	0.37	capreomycin
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	0.37	linezolid	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	0.35	linezolid
rrl	1475638	n.1981C>T	non_coding_transcript_exon_variant	0.26	capreomycin
rrl	1475638	n.1981C>T	non_coding_transcript_exon_variant	0.26	linezolid
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	0.29	capreomycin
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	0.29	linezolid
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	0.25	capreomycin
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1475659	n.2002G>T	non_coding_transcript_exon_variant	0.24	capreomycin
rrl	1475659	n.2002G>T	non_coding_transcript_exon_variant	0.24	linezolid
rrl	1475761	n.2104_2106delCGCinsGT	non_coding_transcript_exon_variant	0.17	capreomycin
rrl	1475761	n.2104_2106delCGCinsGT	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.38	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.38	linezolid
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.22	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.22	linezolid	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	0.21	capreomycin
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1476095	n.2438C>G	non_coding_transcript_exon_variant	0.22	capreomycin
rrl	1476095	n.2438C>G	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1476105	n.2448_2449delGAinsT	non_coding_transcript_exon_variant	0.24	capreomycin
rrl	1476105	n.2448_2449delGAinsT	non_coding_transcript_exon_variant	0.24	linezolid
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.31	capreomycin	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.31	linezolid	Uncertain significance
rrl	1476117	n.2460G>C	non_coding_transcript_exon_variant	0.31	capreomycin
rrl	1476117	n.2460G>C	non_coding_transcript_exon_variant	0.31	linezolid
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.31	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.31	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.35	linezolid	Uncertain significance
rrl	1476297	n.2640C>T	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1476297	n.2640C>T	non_coding_transcript_exon_variant	0.33	linezolid	Uncertain significance
rrl	1476299	n.2642C>T	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1476299	n.2642C>T	non_coding_transcript_exon_variant	0.33	linezolid	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.26	capreomycin	Not assoc w R
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.26	linezolid	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.29	capreomycin	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.29	linezolid	Uncertain significance
rrl	1476689	n.3032A>T	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1476689	n.3032A>T	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1476690	n.3033C>T	non_coding_transcript_exon_variant	0.2	capreomycin	Uncertain significance
rrl	1476690	n.3033C>T	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1476693	n.3036G>A	non_coding_transcript_exon_variant	0.21	capreomycin
rrl	1476693	n.3036G>A	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1476695	n.3038T>A	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1476695	n.3038T>A	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1476716	n.3059A>C	non_coding_transcript_exon_variant	0.19	capreomycin	Uncertain significance
rrl	1476716	n.3059A>C	non_coding_transcript_exon_variant	0.19	linezolid
rrl	1476717	n.3060C>T	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1476717	n.3060C>T	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1476726	n.3069A>G	non_coding_transcript_exon_variant	0.22	capreomycin
rrl	1476726	n.3069A>G	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1476732	n.3075T>C	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1476732	n.3075T>C	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1476746	n.3089T>C	non_coding_transcript_exon_variant	0.15	capreomycin
rrl	1476746	n.3089T>C	non_coding_transcript_exon_variant	0.15	linezolid
inhA	1673547	c.-655T>C	upstream_gene_variant	0.24	isoniazid
inhA	1673547	c.-655T>C	upstream_gene_variant	0.24	ethionamide
inhA	1673569	c.-633G>A	upstream_gene_variant	0.15	isoniazid
inhA	1673569	c.-633G>A	upstream_gene_variant	0.15	ethionamide
inhA	1673710	c.-492_-490delCTAinsATC	upstream_gene_variant	0.19	isoniazid
inhA	1673710	c.-492_-490delCTAinsATC	upstream_gene_variant	0.19	ethionamide
inhA	1673716	c.-486_-485delGCinsAA	upstream_gene_variant	0.18	isoniazid
inhA	1673716	c.-486_-485delGCinsAA	upstream_gene_variant	0.18	ethionamide
inhA	1673733	c.-469G>C	upstream_gene_variant	0.19	isoniazid
inhA	1673733	c.-469G>C	upstream_gene_variant	0.19	ethionamide
inhA	1674114	c.-88T>G	upstream_gene_variant	0.21	isoniazid
inhA	1674114	c.-88T>G	upstream_gene_variant	0.21	ethionamide
inhA	1674123	c.-79T>C	upstream_gene_variant	0.19	isoniazid
inhA	1674123	c.-79T>C	upstream_gene_variant	0.19	ethionamide
inhA	1674129	c.-73C>T	upstream_gene_variant	0.16	isoniazid
inhA	1674129	c.-73C>T	upstream_gene_variant	0.16	ethionamide
inhA	1674132	c.-70T>C	upstream_gene_variant	0.17	isoniazid
inhA	1674132	c.-70T>C	upstream_gene_variant	0.17	ethionamide
inhA	1674135	c.-67C>A	upstream_gene_variant	0.16	isoniazid
inhA	1674135	c.-67C>A	upstream_gene_variant	0.16	ethionamide
inhA	1674136	c.-66T>G	upstream_gene_variant	0.16	isoniazid
inhA	1674136	c.-66T>G	upstream_gene_variant	0.16	ethionamide
inhA	1674471	c.270G>T	synonymous_variant	0.15	isoniazid
inhA	1674471	c.270G>T	synonymous_variant	0.15	ethionamide
inhA	1674489	c.288G>T	synonymous_variant	0.17	isoniazid
inhA	1674489	c.288G>T	synonymous_variant	0.17	ethionamide
inhA	1674537	c.336C>G	synonymous_variant	0.29	isoniazid
inhA	1674537	c.336C>G	synonymous_variant	0.29	ethionamide
inhA	1674542	p.Ala114Glu	missense_variant	0.28	isoniazid
inhA	1674542	p.Ala114Glu	missense_variant	0.28	ethionamide
inhA	1674549	c.348G>C	synonymous_variant	0.28	isoniazid
inhA	1674549	c.348G>C	synonymous_variant	0.28	ethionamide
inhA	1674550	p.Ser117Ala	missense_variant	0.27	isoniazid
inhA	1674550	p.Ser117Ala	missense_variant	0.27	ethionamide
inhA	1674555	c.354G>A	synonymous_variant	0.27	isoniazid	Not assoc w R - Interim
inhA	1674555	c.354G>A	synonymous_variant	0.27	ethionamide	Not assoc w R - Interim
inhA	1674561	c.360C>T	synonymous_variant	0.29	isoniazid
inhA	1674561	c.360C>T	synonymous_variant	0.29	ethionamide
inhA	1674582	c.381T>C	synonymous_variant	0.28	isoniazid
inhA	1674582	c.381T>C	synonymous_variant	0.28	ethionamide
inhA	1674585	c.384T>C	synonymous_variant	0.25	isoniazid
inhA	1674585	c.384T>C	synonymous_variant	0.25	ethionamide
inhA	1674589	p.Met130Leu	missense_variant	0.26	isoniazid
inhA	1674589	p.Met130Leu	missense_variant	0.26	ethionamide
inhA	1674601	p.Leu134Thr	missense_variant	0.22	isoniazid
inhA	1674601	p.Leu134Thr	missense_variant	0.22	ethionamide
inhA	1674624	c.423A>T	synonymous_variant	0.22	isoniazid
inhA	1674624	c.423A>T	synonymous_variant	0.22	ethionamide
inhA	1674627	c.426T>C	synonymous_variant	0.21	isoniazid
inhA	1674627	c.426T>C	synonymous_variant	0.21	ethionamide
inhA	1674636	c.435C>G	synonymous_variant	0.24	isoniazid
inhA	1674636	c.435C>G	synonymous_variant	0.24	ethionamide
inhA	1674651	c.450C>T	synonymous_variant	0.21	isoniazid
inhA	1674651	c.450C>T	synonymous_variant	0.21	ethionamide
inhA	1674690	c.489C>G	synonymous_variant	0.2	isoniazid
inhA	1674690	c.489C>G	synonymous_variant	0.2	ethionamide
inhA	1674703	c.502T>C	synonymous_variant	0.2	isoniazid
inhA	1674703	c.502T>C	synonymous_variant	0.2	ethionamide
inhA	1674708	c.507G>A	synonymous_variant	0.17	isoniazid
inhA	1674708	c.507G>A	synonymous_variant	0.17	ethionamide
inhA	1674714	c.513C>G	synonymous_variant	0.16	isoniazid
inhA	1674714	c.513C>G	synonymous_variant	0.16	ethionamide
inhA	1674729	c.528G>T	synonymous_variant	0.14	isoniazid
inhA	1674729	c.528G>T	synonymous_variant	0.14	ethionamide
inhA	1674840	c.639C>G	synonymous_variant	0.21	isoniazid
inhA	1674840	c.639C>G	synonymous_variant	0.21	ethionamide
inhA	1674846	p.Ile215Met	missense_variant	0.22	isoniazid
inhA	1674846	p.Ile215Met	missense_variant	0.22	ethionamide
inhA	1674858	c.657G>A	synonymous_variant	0.24	isoniazid
inhA	1674858	c.657G>A	synonymous_variant	0.24	ethionamide
inhA	1674870	c.669T>C	synonymous_variant	0.26	isoniazid
inhA	1674870	c.669T>C	synonymous_variant	0.26	ethionamide
inhA	1674879	c.678T>C	synonymous_variant	0.25	isoniazid
inhA	1674879	c.678T>C	synonymous_variant	0.25	ethionamide
inhA	1674903	c.702T>C	synonymous_variant	0.21	isoniazid
inhA	1674903	c.702T>C	synonymous_variant	0.21	ethionamide
inhA	1674904	p.Ala235Pro	missense_variant	0.21	isoniazid
inhA	1674904	p.Ala235Pro	missense_variant	0.21	ethionamide
inhA	1674934	c.733C>T	synonymous_variant	0.24	isoniazid
inhA	1674934	c.733C>T	synonymous_variant	0.24	ethionamide
inhA	1674939	c.738G>C	synonymous_variant	0.25	isoniazid
inhA	1674939	c.738G>C	synonymous_variant	0.25	ethionamide
inhA	1674942	c.741T>G	synonymous_variant	0.23	isoniazid
inhA	1674942	c.741T>G	synonymous_variant	0.23	ethionamide
inhA	1674954	c.753G>T	synonymous_variant	0.26	isoniazid
inhA	1674954	c.753G>T	synonymous_variant	0.26	ethionamide
inhA	1674960	c.759C>G	synonymous_variant	0.27	isoniazid
inhA	1674960	c.759C>G	synonymous_variant	0.27	ethionamide
inhA	1674966	c.765T>G	synonymous_variant	0.23	isoniazid
inhA	1674966	c.765T>G	synonymous_variant	0.23	ethionamide
inhA	1674967	p.Asp256Thr	missense_variant	0.2	isoniazid
inhA	1674967	p.Asp256Thr	missense_variant	0.2	ethionamide
rpsA	1833554	p.Thr5Ala	missense_variant	0.16	pyrazinamide	Uncertain significance
rpsA	1833589	c.48A>T	synonymous_variant	0.2	pyrazinamide
rpsA	1833595	c.54T>G	synonymous_variant	0.21	pyrazinamide
rpsA	1833667	c.126C>G	synonymous_variant	0.28	pyrazinamide
rpsA	1833703	c.162C>T	synonymous_variant	0.26	pyrazinamide	Not assoc w R - Interim
rpsA	1833724	c.183C>G	synonymous_variant	0.18	pyrazinamide
rpsA	1833727	c.186G>C	synonymous_variant	0.17	pyrazinamide
rpsA	1833745	c.204G>C	synonymous_variant	0.2	pyrazinamide
rpsA	1833760	c.219C>T	synonymous_variant	0.2	pyrazinamide	Not assoc w R - Interim
rpsA	1833793	c.252C>T	synonymous_variant	0.23	pyrazinamide
rpsA	1833874	c.333T>C	synonymous_variant	0.2	pyrazinamide
rpsA	1833928	c.387G>C	synonymous_variant	0.28	pyrazinamide
rpsA	1833971	c.430C>T	synonymous_variant	0.25	pyrazinamide
rpsA	1833979	c.438T>C	synonymous_variant	0.21	pyrazinamide
rpsA	1834000	c.459G>C	synonymous_variant	0.27	pyrazinamide
rpsA	1834021	c.480C>T	synonymous_variant	0.27	pyrazinamide
rpsA	1834030	c.489C>G	synonymous_variant	0.3	pyrazinamide
rpsA	1834097	c.556_557delTCinsAG	synonymous_variant	0.19	pyrazinamide
rpsA	1834102	c.561T>G	synonymous_variant	0.18	pyrazinamide
rpsA	1834177	c.636A>C	synonymous_variant	0.16	pyrazinamide	Not assoc w R - Interim
rpsA	1834186	c.645C>G	synonymous_variant	0.21	pyrazinamide
rpsA	1834192	c.651C>G	synonymous_variant	0.23	pyrazinamide	Not assoc w R - Interim
rpsA	1834222	c.681T>C	synonymous_variant	0.24	pyrazinamide
rpsA	1834240	c.699T>C	synonymous_variant	0.29	pyrazinamide
rpsA	1834249	c.708T>C	synonymous_variant	0.29	pyrazinamide
rpsA	1834261	c.720A>G	synonymous_variant	0.28	pyrazinamide	Not assoc w R - Interim
rpsA	1834264	c.723G>C	synonymous_variant	0.26	pyrazinamide
rpsA	1834294	c.753G>T	synonymous_variant	0.23	pyrazinamide
rpsA	1834297	c.756C>T	synonymous_variant	0.23	pyrazinamide
rpsA	1834303	c.762T>C	synonymous_variant	0.22	pyrazinamide
rpsA	1834306	c.765T>C	synonymous_variant	0.22	pyrazinamide
rpsA	1834348	c.807T>C	synonymous_variant	0.22	pyrazinamide	Not assoc w R - Interim
rpsA	1834366	c.825A>G	synonymous_variant	0.23	pyrazinamide	Not assoc w R - Interim
rpsA	1834369	c.828C>G	synonymous_variant	0.23	pyrazinamide
rpsA	1834396	c.855G>C	synonymous_variant	0.25	pyrazinamide
rpsA	1834411	c.870T>C	synonymous_variant	0.23	pyrazinamide
rpsA	1834417	c.876G>C	synonymous_variant	0.23	pyrazinamide
rpsA	1834423	c.882G>C	synonymous_variant	0.23	pyrazinamide
rpsA	1834435	c.894G>C	synonymous_variant	0.24	pyrazinamide
rpsA	1834451	c.910T>C	synonymous_variant	0.24	pyrazinamide
rpsA	1834468	c.927A>G	synonymous_variant	0.24	pyrazinamide
rpsA	1834474	c.933C>G	synonymous_variant	0.26	pyrazinamide
rpsA	1834477	c.936C>T	synonymous_variant	0.28	pyrazinamide	Not assoc w R - Interim
rpsA	1834489	c.948T>C	synonymous_variant	0.32	pyrazinamide
rpsA	1834516	c.975G>A	synonymous_variant	0.32	pyrazinamide
rpsA	1834528	c.987T>C	synonymous_variant	0.33	pyrazinamide
rpsA	1834540	c.999G>T	synonymous_variant	0.31	pyrazinamide	Not assoc w R - Interim
rpsA	1834546	c.1005T>C	synonymous_variant	0.3	pyrazinamide
rpsA	1834555	c.1014T>C	synonymous_variant	0.28	pyrazinamide
rpsA	1834606	c.1065C>G	synonymous_variant	0.26	pyrazinamide
rpsA	1834609	c.1068T>C	synonymous_variant	0.25	pyrazinamide
rpsA	1834633	c.1092A>G	synonymous_variant	0.26	pyrazinamide
rpsA	1834639	c.1098T>C	synonymous_variant	0.25	pyrazinamide
rpsA	1834654	p.Glu371Asp	missense_variant	0.23	pyrazinamide
rpsA	1834669	c.1128G>C	synonymous_variant	0.21	pyrazinamide
rpsA	1834690	c.1149T>C	synonymous_variant	0.19	pyrazinamide
rpsA	1834732	c.1191T>C	synonymous_variant	0.21	pyrazinamide
rpsA	1834738	c.1197A>G	synonymous_variant	0.22	pyrazinamide
rpsA	1834753	c.1212T>C	synonymous_variant	0.23	pyrazinamide
rpsA	1834759	c.1218A>C	synonymous_variant	0.24	pyrazinamide
rpsA	1834765	p.Glu408Asp	missense_variant	0.24	pyrazinamide
rpsA	1834775	p.Ala412Asn	missense_variant	0.23	pyrazinamide
rpsA	1834780	c.1239A>G	synonymous_variant	0.23	pyrazinamide
rpsA	1834789	c.1248T>C	synonymous_variant	0.25	pyrazinamide
rpsA	1834792	c.1251G>C	synonymous_variant	0.24	pyrazinamide
rpsA	1834828	c.1287C>G	synonymous_variant	0.18	pyrazinamide
tsnR	1853387	c.-219T>G	upstream_gene_variant	0.16	linezolid
tsnR	1853390	c.-216G>A	upstream_gene_variant	0.16	linezolid
tsnR	1853394	c.-212_-211delCTinsGC	upstream_gene_variant	0.16	linezolid
tsnR	1853420	c.-186T>G	upstream_gene_variant	0.16	linezolid
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
bacA	2064194	p.Glu179Lys	missense_variant	0.14	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
bacA	2064945	c.-217G>A	upstream_gene_variant	0.18	kanamycin
					capreomycin
					streptomycin
					amikacin
bacA	2064948	c.-220G>C	upstream_gene_variant	0.19	kanamycin
					capreomycin
					streptomycin
					amikacin
ndh	2102233	c.810G>A	synonymous_variant	0.17	isoniazid	Not assoc w R - Interim
					delamanid
					ethionamide	Not assoc w R - Interim
ndh	2102260	c.783C>T	synonymous_variant	0.27	isoniazid
					delamanid
					ethionamide
ndh	2102266	c.777C>G	synonymous_variant	0.26	isoniazid
					delamanid
					ethionamide
ndh	2102317	c.726A>G	synonymous_variant	0.25	isoniazid
					delamanid
					ethionamide
ndh	2102328	p.Leu239Met	missense_variant	0.25	isoniazid
					delamanid
					ethionamide
ndh	2102334	p.Gln237Glu	missense_variant	0.2	isoniazid
					delamanid
					ethionamide
ndh	2102337	c.706T>C	synonymous_variant	0.2	isoniazid
					delamanid
					ethionamide	Not assoc w R - Interim
ndh	2102344	c.699T>G	synonymous_variant	0.15	isoniazid
					delamanid
					ethionamide
ndh	2102350	c.693G>T	synonymous_variant	0.16	isoniazid
					delamanid
					ethionamide
ndh	2102671	c.372T>G	synonymous_variant	0.18	isoniazid
					delamanid
					ethionamide
ndh	2102680	c.363T>G	synonymous_variant	0.18	isoniazid
					delamanid
					ethionamide
ndh	2102683	c.360T>C	synonymous_variant	0.18	isoniazid
					delamanid
					ethionamide
ndh	2102686	c.357G>C	synonymous_variant	0.18	isoniazid
					delamanid
					ethionamide
ndh	2102694	p.Val117Ile	missense_variant	0.17	isoniazid	Uncertain significance
					delamanid	Uncertain significance
					ethionamide	Uncertain significance
ndh	2102701	c.342C>T	synonymous_variant	0.16	isoniazid
					delamanid
					ethionamide
ndh	2102710	c.333C>T	synonymous_variant	0.14	isoniazid
					delamanid
					ethionamide
katG	2154724	p.Arg463Leu	missense_variant	1.0	isoniazid	Not assoc w R
PPE35	2167926	p.Leu896Ser	missense_variant	1.0	pyrazinamide	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
pncA	2289365	c.-125delC	upstream_gene_variant	1.0	pyrazinamide
kasA	2517917	c.-198G>T	upstream_gene_variant	0.23	isoniazid
kasA	2517926	c.-189G>A	upstream_gene_variant	0.24	isoniazid
kasA	2517950	c.-165C>T	upstream_gene_variant	0.21	isoniazid
kasA	2517965	c.-150C>T	upstream_gene_variant	0.18	isoniazid
kasA	2517974	c.-141T>C	upstream_gene_variant	0.18	isoniazid
kasA	2517989	c.-126T>C	upstream_gene_variant	0.17	isoniazid
kasA	2517993	c.-122G>T	upstream_gene_variant	0.16	isoniazid
kasA	2518162	c.48G>A	synonymous_variant	0.16	isoniazid
kasA	2518168	c.54C>T	synonymous_variant	0.17	isoniazid
kasA	2518172	p.Thr20Ala	missense_variant	0.17	isoniazid
kasA	2518183	c.69G>A	synonymous_variant	0.21	isoniazid
kasA	2518190	p.Ser26Ala	missense_variant	0.24	isoniazid
kasA	2518220	c.106C>T	synonymous_variant	0.23	isoniazid
kasA	2518234	c.120G>A	synonymous_variant	0.2	isoniazid
kasA	2518248	p.Ala45Val	missense_variant	0.16	isoniazid
kasA	2518561	c.447T>C	synonymous_variant	0.16	isoniazid
kasA	2518588	c.474T>C	synonymous_variant	0.16	isoniazid
kasA	2518591	c.477G>T	synonymous_variant	0.16	isoniazid
kasA	2518597	c.483C>G	synonymous_variant	0.16	isoniazid
kasA	2518609	p.Met165Ile	missense_variant	0.15	isoniazid
kasA	2518621	c.507G>T	synonymous_variant	0.16	isoniazid
kasA	2518627	c.513T>C	synonymous_variant	0.19	isoniazid
kasA	2518636	c.522C>T	synonymous_variant	0.21	isoniazid
kasA	2518642	c.528A>G	synonymous_variant	0.22	isoniazid
kasA	2518672	c.558G>C	synonymous_variant	0.23	isoniazid
kasA	2518678	c.564C>T	synonymous_variant	0.23	isoniazid
kasA	2518684	c.570C>G	synonymous_variant	0.24	isoniazid
kasA	2518688	p.Val192Phe	missense_variant	0.24	isoniazid
kasA	2518696	c.582C>T	synonymous_variant	0.24	isoniazid
kasA	2518702	c.588C>T	synonymous_variant	0.24	isoniazid
kasA	2518705	c.591T>G	synonymous_variant	0.25	isoniazid
kasA	2518711	c.597A>G	synonymous_variant	0.23	isoniazid
kasA	2518714	c.600A>T	synonymous_variant	0.22	isoniazid
kasA	2518723	c.609G>A	synonymous_variant	0.23	isoniazid
kasA	2518747	c.633C>G	synonymous_variant	0.2	isoniazid
kasA	2518768	c.654C>G	synonymous_variant	0.15	isoniazid
ahpC	2726105	c.-88G>A	upstream_gene_variant	1.0	isoniazid	Not assoc w R
ahpC	2726669	p.Asp159Glu	missense_variant	0.16	isoniazid
ahpC	2726675	c.483A>G	synonymous_variant	0.17	isoniazid
ahpC	2726681	c.489A>C	synonymous_variant	0.16	isoniazid	Not assoc w R - Interim
ahpC	2726684	c.492G>C	synonymous_variant	0.15	isoniazid
ahpC	2726693	c.501C>A	synonymous_variant	0.15	isoniazid
ahpC	2726696	c.504C>G	synonymous_variant	0.15	isoniazid
folC	2747032	c.567A>C	synonymous_variant	0.16	para-aminosalicylic_acid
folC	2747059	c.540T>C	synonymous_variant	0.27	para-aminosalicylic_acid
folC	2747086	c.513A>C	synonymous_variant	0.29	para-aminosalicylic_acid
folC	2747089	c.510G>C	synonymous_variant	0.27	para-aminosalicylic_acid
folC	2747101	c.498G>C	synonymous_variant	0.25	para-aminosalicylic_acid
folC	2747107	c.492G>C	synonymous_variant	0.22	para-aminosalicylic_acid
folC	2747110	c.489T>C	synonymous_variant	0.2	para-aminosalicylic_acid
folC	2747113	c.486C>G	synonymous_variant	0.2	para-aminosalicylic_acid
folC	2747116	c.483G>C	synonymous_variant	0.21	para-aminosalicylic_acid
folC	2747314	c.285A>T	synonymous_variant	0.14	para-aminosalicylic_acid
folC	2747317	c.282C>G	synonymous_variant	0.15	para-aminosalicylic_acid
folC	2747359	c.240C>G	synonymous_variant	0.15	para-aminosalicylic_acid
Rv2477c	2782483	c.1560G>C	synonymous_variant	0.18	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782498	c.1545C>T	synonymous_variant	0.78	kanamycin	Not assoc w R
					levofloxacin	Not assoc w R
					moxifloxacin	Not assoc w R
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R
					ethambutol	Not assoc w R
					amikacin	Not assoc w R
Rv2477c	2782510	c.1533G>C	synonymous_variant	0.24	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782528	c.1515G>C	synonymous_variant	0.2	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782537	c.1506T>G	synonymous_variant	0.17	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782540	c.1503T>C	synonymous_variant	0.16	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782669	c.1374A>G	synonymous_variant	0.19	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782680	c.1363T>C	synonymous_variant	0.25	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782684	c.1359T>C	synonymous_variant	0.26	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782705	c.1338G>C	synonymous_variant	0.32	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782708	c.1335C>T	synonymous_variant	0.32	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2782714	c.1329A>C	synonymous_variant	0.32	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782720	c.1323T>G	synonymous_variant	0.32	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782729	c.1314A>G	synonymous_variant	0.27	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782732	c.1311A>G	synonymous_variant	0.28	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782738	c.1305C>T	synonymous_variant	0.26	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782750	c.1293T>C	synonymous_variant	0.21	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782759	c.1284A>G	synonymous_variant	0.15	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782913	p.Ser377Ile	missense_variant	0.2	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782927	p.Thr372Gln	missense_variant	0.21	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782957	c.1086A>G	synonymous_variant	0.27	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2782969	c.1074A>C	synonymous_variant	0.26	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782981	c.1062G>T	synonymous_variant	0.2	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782984	c.1059T>C	synonymous_variant	0.18	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783002	c.1041T>C	synonymous_variant	0.16	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783008	c.1035C>G	synonymous_variant	0.17	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783077	c.966T>C	synonymous_variant	0.18	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783095	c.948C>G	synonymous_variant	0.22	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783098	c.945C>G	synonymous_variant	0.22	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783101	c.942G>C	synonymous_variant	0.23	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783116	c.927T>C	synonymous_variant	0.27	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783140	c.903C>G	synonymous_variant	0.31	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783149	c.894G>C	synonymous_variant	0.34	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol
					amikacin	Not assoc w R - Interim
Rv2477c	2783158	c.885A>C	synonymous_variant	0.37	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783182	c.861C>G	synonymous_variant	0.35	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783193	p.Ser284Gly	missense_variant	0.27	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783194	c.849A>G	synonymous_variant	0.27	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783203	c.840C>T	synonymous_variant	0.25	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783221	c.822G>C	synonymous_variant	0.19	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783224	c.819C>G	synonymous_variant	0.19	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783230	c.813T>C	synonymous_variant	0.18	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783254	c.789A>G	synonymous_variant	0.2	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783263	c.780G>C	synonymous_variant	0.23	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783278	c.765A>G	synonymous_variant	0.27	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783289	p.Leu252Ile	missense_variant	0.23	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783296	c.747C>T	synonymous_variant	0.23	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783299	c.744A>G	synonymous_variant	0.24	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783302	c.741A>G	synonymous_variant	0.24	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783311	c.732T>C	synonymous_variant	0.3	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783332	c.711T>C	synonymous_variant	0.33	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783335	c.708C>G	synonymous_variant	0.34	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783350	c.693T>C	synonymous_variant	0.3	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783353	c.690T>C	synonymous_variant	0.29	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783356	c.687C>G	synonymous_variant	0.29	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783359	c.684G>A	synonymous_variant	0.28	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783374	c.669G>C	synonymous_variant	0.27	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783395	c.648T>G	synonymous_variant	0.21	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783572	c.471A>G	synonymous_variant	0.19	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783586	p.Ala153Pro	missense_variant	0.18	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783593	c.450T>C	synonymous_variant	0.21	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783599	c.444G>A	synonymous_variant	0.25	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783605	c.438T>C	synonymous_variant	0.3	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783620	c.423C>G	synonymous_variant	0.35	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783628	p.Ala139Ser	missense_variant	0.32	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783629	c.414C>T	synonymous_variant	0.31	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783665	c.378A>G	synonymous_variant	0.26	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783674	c.369T>G	synonymous_variant	0.26	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783680	c.363G>A	synonymous_variant	0.22	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783683	c.360A>G	synonymous_variant	0.21	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783691	c.352C>T	synonymous_variant	0.19	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783695	c.348C>T	synonymous_variant	0.15	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783700	p.Thr115Ser	missense_variant	0.14	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783846	p.Thr66Asn	missense_variant	0.21	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783853	c.190C>T	synonymous_variant	0.31	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783863	c.180C>T	synonymous_variant	0.39	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783883	c.160T>C	synonymous_variant	0.42	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783884	c.159T>C	synonymous_variant	0.42	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783887	c.156C>G	synonymous_variant	0.51	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783914	c.129T>C	synonymous_variant	0.53	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783920	c.123G>C	synonymous_variant	0.53	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783950	c.93C>T	synonymous_variant	0.41	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783953	c.90G>A	synonymous_variant	0.39	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783962	c.81T>C	synonymous_variant	0.39	kanamycin	Not assoc w R - Interim
					levofloxacin
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783971	c.72G>C	synonymous_variant	0.38	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783980	c.63C>G	synonymous_variant	0.4	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783992	c.51T>C	synonymous_variant	0.41	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin
Rv2477c	2784016	c.27G>A	synonymous_variant	0.37	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2784051	c.-9C>A	upstream_gene_variant	0.2	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2784052	c.-10A>T	upstream_gene_variant	0.17	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
pepQ	2859882	c.537G>C	synonymous_variant	0.15	bedaquiline
pepQ	2859882	c.537G>C	synonymous_variant	0.15	clofazimine
pepQ	2859903	c.516G>C	synonymous_variant	0.18	bedaquiline
pepQ	2859903	c.516G>C	synonymous_variant	0.18	clofazimine
pepQ	2859908	p.Gln171Glu	missense_variant	0.17	bedaquiline
pepQ	2859908	p.Gln171Glu	missense_variant	0.17	clofazimine
pepQ	2859909	c.510G>C	synonymous_variant	0.16	bedaquiline
pepQ	2859909	c.510G>C	synonymous_variant	0.16	clofazimine
pepQ	2859918	c.501A>G	synonymous_variant	0.16	bedaquiline
pepQ	2859918	c.501A>G	synonymous_variant	0.16	clofazimine
pepQ	2859921	c.498C>G	synonymous_variant	0.17	bedaquiline
pepQ	2859921	c.498C>G	synonymous_variant	0.17	clofazimine
Rv2681	2996593	c.-146T>C	upstream_gene_variant	0.15	capreomycin
Rv2681	2996940	p.Gly68Asn	missense_variant	0.17	capreomycin
Rv2681	2996957	c.219T>C	synonymous_variant	0.18	capreomycin
Rv2752c	3064838	c.1354T>C	synonymous_variant	0.16	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3064860	c.1332G>C	synonymous_variant	0.15	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066054	c.138T>G	synonymous_variant	0.17	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066065	p.Ile43Val	missense_variant	0.18	levofloxacin
					moxifloxacin
					isoniazid	Uncertain significance
					rifampicin	Uncertain significance
					ethambutol	Uncertain significance
Rv2752c	3066066	c.126T>C	synonymous_variant	0.19	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066075	c.117A>G	synonymous_variant	0.2	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066087	c.105A>G	synonymous_variant	0.15	levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
thyX	3067304	c.642A>G	synonymous_variant	0.17	para-aminosalicylic_acid
thyX	3067313	c.633G>C	synonymous_variant	0.16	para-aminosalicylic_acid
thyX	3067316	c.630A>G	synonymous_variant	0.16	para-aminosalicylic_acid
thyX	3067319	c.627G>C	synonymous_variant	0.17	para-aminosalicylic_acid
thyX	3067349	c.597G>C	synonymous_variant	0.25	para-aminosalicylic_acid
thyX	3067355	c.591A>C	synonymous_variant	0.25	para-aminosalicylic_acid
thyX	3067373	c.573C>G	synonymous_variant	0.25	para-aminosalicylic_acid
thyX	3067394	c.552G>C	synonymous_variant	0.21	para-aminosalicylic_acid
thyX	3067406	c.540A>G	synonymous_variant	0.21	para-aminosalicylic_acid
thyX	3067412	c.534C>G	synonymous_variant	0.2	para-aminosalicylic_acid
thyX	3067427	c.519G>C	synonymous_variant	0.17	para-aminosalicylic_acid
thyX	3067811	c.135G>A	synonymous_variant	0.15	para-aminosalicylic_acid
thyX	3067838	c.108C>G	synonymous_variant	0.17	para-aminosalicylic_acid
thyX	3067850	c.96A>C	synonymous_variant	0.15	para-aminosalicylic_acid
thyX	3067869	p.Thr26Ser	missense_variant	0.2	para-aminosalicylic_acid
thyX	3067874	c.72C>G	synonymous_variant	0.2	para-aminosalicylic_acid
thyX	3067883	c.63C>G	synonymous_variant	0.19	para-aminosalicylic_acid
thyX	3067886	c.60A>C	synonymous_variant	0.19	para-aminosalicylic_acid
thyX	3067889	c.57C>G	synonymous_variant	0.18	para-aminosalicylic_acid
thyA	3073959	c.513T>C	synonymous_variant	0.19	para-aminosalicylic_acid
thyA	3073977	c.495A>G	synonymous_variant	0.25	para-aminosalicylic_acid
thyA	3073989	c.483T>C	synonymous_variant	0.29	para-aminosalicylic_acid
thyA	3074001	c.471C>G	synonymous_variant	0.29	para-aminosalicylic_acid
thyA	3074004	c.468T>C	synonymous_variant	0.28	para-aminosalicylic_acid
thyA	3074010	c.462C>G	synonymous_variant	0.27	para-aminosalicylic_acid
thyA	3074031	c.441T>C	synonymous_variant	0.25	para-aminosalicylic_acid
thyA	3074037	c.435C>G	synonymous_variant	0.25	para-aminosalicylic_acid
thyA	3074056	p.Glu139Pro	missense_variant	0.23	para-aminosalicylic_acid
thyA	3074061	c.411A>G	synonymous_variant	0.23	para-aminosalicylic_acid
thyA	3074076	c.396C>G	synonymous_variant	0.22	para-aminosalicylic_acid
ald	3086788	c.-32T>C	upstream_gene_variant	1.0	cycloserine
lpqB	3624646	c.265T>C	synonymous_variant	0.15	rifampicin
lpqB	3624646	c.265T>C	synonymous_variant	0.15	bedaquiline
lpqB	3624649	c.262T>C	synonymous_variant	0.15	rifampicin
lpqB	3624649	c.262T>C	synonymous_variant	0.15	bedaquiline
lpqB	3624656	c.255C>T	synonymous_variant	0.16	rifampicin
lpqB	3624656	c.255C>T	synonymous_variant	0.16	bedaquiline
lpqB	3624680	c.231T>G	synonymous_variant	0.22	rifampicin
lpqB	3624680	c.231T>G	synonymous_variant	0.22	bedaquiline
lpqB	3624686	p.Glu75Gln	missense_variant	0.23	rifampicin
lpqB	3624686	p.Glu75Gln	missense_variant	0.23	bedaquiline
mtrB	3625065	p.Met517Leu	missense_variant	1.0	rifampicin	Not assoc w R
mtrB	3625065	p.Met517Leu	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3625246	c.-336G>A	upstream_gene_variant	0.15	rifampicin
lpqB	3625246	c.-336G>A	upstream_gene_variant	0.15	bedaquiline
lpqB	3625255	c.-345T>C	upstream_gene_variant	0.2	rifampicin
lpqB	3625255	c.-345T>C	upstream_gene_variant	0.2	bedaquiline
lpqB	3625258	c.-348G>C	upstream_gene_variant	0.21	rifampicin
lpqB	3625258	c.-348G>C	upstream_gene_variant	0.21	bedaquiline
mtrB	3625267	c.1347T>C	synonymous_variant	0.22	rifampicin	Not assoc w R - Interim
mtrB	3625267	c.1347T>C	synonymous_variant	0.22	bedaquiline
lpqB	3625270	c.-360G>C	upstream_gene_variant	0.21	rifampicin
lpqB	3625270	c.-360G>C	upstream_gene_variant	0.21	bedaquiline
lpqB	3625291	c.-381A>G	upstream_gene_variant	0.25	rifampicin
lpqB	3625291	c.-381A>G	upstream_gene_variant	0.25	bedaquiline
mtrB	3625313	p.Arg434Lys	missense_variant	0.15	rifampicin
mtrB	3625313	p.Arg434Lys	missense_variant	0.15	bedaquiline
mtrB	3625321	c.1293A>G	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
mtrB	3625321	c.1293A>G	synonymous_variant	0.16	bedaquiline	Not assoc w R - Interim
mtrB	3625592	p.Ser341Asn	missense_variant	0.14	rifampicin
mtrB	3625592	p.Ser341Asn	missense_variant	0.14	bedaquiline
lpqB	3625594	c.-684T>C	upstream_gene_variant	0.15	rifampicin
lpqB	3625594	c.-684T>C	upstream_gene_variant	0.15	bedaquiline
lpqB	3625602	c.-692T>C	upstream_gene_variant	0.17	rifampicin
lpqB	3625602	c.-692T>C	upstream_gene_variant	0.17	bedaquiline
lpqB	3625612	c.-702G>C	upstream_gene_variant	0.16	rifampicin
lpqB	3625612	c.-702G>C	upstream_gene_variant	0.16	bedaquiline
mtrB	3625616	p.Arg333Ala	missense_variant	0.16	rifampicin
mtrB	3625616	p.Arg333Ala	missense_variant	0.16	bedaquiline
lpqB	3625624	c.-714C>G	upstream_gene_variant	0.24	rifampicin
lpqB	3625624	c.-714C>G	upstream_gene_variant	0.24	bedaquiline
lpqB	3625630	c.-720C>G	upstream_gene_variant	0.29	rifampicin
lpqB	3625630	c.-720C>G	upstream_gene_variant	0.29	bedaquiline
mtrB	3625636	c.978C>G	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
mtrB	3625636	c.978C>G	synonymous_variant	0.3	bedaquiline
mtrB	3625656	c.958T>C	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
mtrB	3625656	c.958T>C	synonymous_variant	0.32	bedaquiline	Not assoc w R - Interim
lpqB	3625663	c.-753G>C	upstream_gene_variant	0.3	rifampicin
lpqB	3625663	c.-753G>C	upstream_gene_variant	0.3	bedaquiline
lpqB	3625687	c.-777G>C	upstream_gene_variant	0.33	rifampicin
lpqB	3625687	c.-777G>C	upstream_gene_variant	0.33	bedaquiline
lpqB	3625690	c.-780T>C	upstream_gene_variant	0.31	rifampicin
lpqB	3625690	c.-780T>C	upstream_gene_variant	0.31	bedaquiline
mtrB	3625705	c.909C>G	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
mtrB	3625705	c.909C>G	synonymous_variant	0.33	bedaquiline
mtrB	3625711	c.903C>T	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
mtrB	3625711	c.903C>T	synonymous_variant	0.29	bedaquiline
lpqB	3625714	c.-804C>T	upstream_gene_variant	0.28	rifampicin
lpqB	3625714	c.-804C>T	upstream_gene_variant	0.28	bedaquiline
mtrB	3625720	c.894G>C	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
mtrB	3625720	c.894G>C	synonymous_variant	0.29	bedaquiline
mtrB	3625729	c.885A>G	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
mtrB	3625729	c.885A>G	synonymous_variant	0.28	bedaquiline
mtrB	3625732	c.882C>T	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
mtrB	3625732	c.882C>T	synonymous_variant	0.28	bedaquiline
lpqB	3625735	c.-825C>T	upstream_gene_variant	0.27	rifampicin
lpqB	3625735	c.-825C>T	upstream_gene_variant	0.27	bedaquiline
mtrB	3625755	p.Ala287Thr	missense_variant	0.24	rifampicin	Uncertain significance
mtrB	3625755	p.Ala287Thr	missense_variant	0.24	bedaquiline
lpqB	3625762	c.-852A>C	upstream_gene_variant	0.21	rifampicin
lpqB	3625762	c.-852A>C	upstream_gene_variant	0.21	bedaquiline
mtrB	3625765	c.849C>G	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
mtrB	3625765	c.849C>G	synonymous_variant	0.21	bedaquiline
mtrB	3625806	c.808A>C	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
mtrB	3625806	c.808A>C	synonymous_variant	0.16	bedaquiline
mtrB	3625807	c.807C>G	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
mtrB	3625807	c.807C>G	synonymous_variant	0.16	bedaquiline
mtrB	3625852	c.762A>G	synonymous_variant	0.22	rifampicin	Not assoc w R - Interim
mtrB	3625852	c.762A>G	synonymous_variant	0.22	bedaquiline
lpqB	3625864	c.-954T>G	upstream_gene_variant	0.19	rifampicin
lpqB	3625864	c.-954T>G	upstream_gene_variant	0.19	bedaquiline
lpqB	3625870	c.-960C>A	upstream_gene_variant	0.16	rifampicin
lpqB	3625870	c.-960C>A	upstream_gene_variant	0.16	bedaquiline
mtrB	3626317	c.297A>G	synonymous_variant	0.17	rifampicin	Not assoc w R - Interim
mtrB	3626317	c.297A>G	synonymous_variant	0.17	bedaquiline
mtrB	3626325	p.Thr97Ala	missense_variant	0.18	rifampicin
mtrB	3626325	p.Thr97Ala	missense_variant	0.18	bedaquiline
mtrB	3626329	c.285G>A	synonymous_variant	0.18	rifampicin
mtrB	3626329	c.285G>A	synonymous_variant	0.18	bedaquiline
mtrB	3626332	c.282T>C	synonymous_variant	0.2	rifampicin
mtrB	3626332	c.282T>C	synonymous_variant	0.2	bedaquiline
mtrB	3626349	p.Ser89Gly	missense_variant	0.26	rifampicin
mtrB	3626349	p.Ser89Gly	missense_variant	0.26	bedaquiline
mtrB	3626350	c.264C>G	synonymous_variant	0.27	rifampicin
mtrB	3626350	c.264C>G	synonymous_variant	0.27	bedaquiline
mtrB	3626377	p.Asp79Glu	missense_variant	0.26	rifampicin
mtrB	3626377	p.Asp79Glu	missense_variant	0.26	bedaquiline
mtrB	3626383	c.231G>C	synonymous_variant	0.24	rifampicin
mtrB	3626383	c.231G>C	synonymous_variant	0.24	bedaquiline
mtrB	3626386	c.228G>C	synonymous_variant	0.25	rifampicin
mtrB	3626386	c.228G>C	synonymous_variant	0.25	bedaquiline
mtrB	3626390	p.Arg75Lys	missense_variant	0.25	rifampicin
mtrB	3626390	p.Arg75Lys	missense_variant	0.25	bedaquiline
mtrB	3626400	p.Ile72Val	missense_variant	0.21	rifampicin
mtrB	3626400	p.Ile72Val	missense_variant	0.21	bedaquiline
mtrB	3626407	c.207C>G	synonymous_variant	0.2	rifampicin
mtrB	3626407	c.207C>G	synonymous_variant	0.2	bedaquiline
mtrB	3626410	c.204T>C	synonymous_variant	0.21	rifampicin
mtrB	3626410	c.204T>C	synonymous_variant	0.21	bedaquiline
mtrB	3626425	c.189C>T	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
mtrB	3626425	c.189C>T	synonymous_variant	0.16	bedaquiline
mtrB	3626744	c.-131G>C	upstream_gene_variant	0.16	rifampicin
mtrB	3626744	c.-131G>C	upstream_gene_variant	0.16	bedaquiline
mtrA	3626759	c.591T>C	synonymous_variant	0.17	rifampicin	Not assoc w R - Interim
mtrA	3626759	c.591T>C	synonymous_variant	0.17	bedaquiline
mtrB	3626774	c.-163_-161delAGGinsCGC	upstream_gene_variant	0.16	rifampicin
mtrB	3626774	c.-163_-161delAGGinsCGC	upstream_gene_variant	0.16	bedaquiline
mtrB	3626783	c.-170C>G	upstream_gene_variant	0.18	rifampicin
mtrB	3626783	c.-170C>G	upstream_gene_variant	0.18	bedaquiline
mtrA	3626786	c.564A>G	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
mtrA	3626786	c.564A>G	synonymous_variant	0.19	bedaquiline
mtrA	3626792	c.558G>T	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
mtrA	3626792	c.558G>T	synonymous_variant	0.21	bedaquiline
mtrB	3626795	c.-182C>T	upstream_gene_variant	0.21	rifampicin
mtrB	3626795	c.-182C>T	upstream_gene_variant	0.21	bedaquiline
mtrB	3626798	c.-185T>C	upstream_gene_variant	0.24	rifampicin
mtrB	3626798	c.-185T>C	upstream_gene_variant	0.24	bedaquiline
mtrA	3626804	c.546A>G	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
mtrA	3626804	c.546A>G	synonymous_variant	0.27	bedaquiline
mtrB	3626840	c.-227C>G	upstream_gene_variant	0.28	rifampicin
mtrB	3626840	c.-227C>G	upstream_gene_variant	0.28	bedaquiline
mtrA	3626846	c.504G>A	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
mtrA	3626846	c.504G>A	synonymous_variant	0.28	bedaquiline
mtrB	3626849	c.-236C>T	upstream_gene_variant	0.31	rifampicin
mtrB	3626849	c.-236C>T	upstream_gene_variant	0.31	bedaquiline
mtrB	3626858	c.-245A>G	upstream_gene_variant	0.26	rifampicin
mtrB	3626858	c.-245A>G	upstream_gene_variant	0.26	bedaquiline
mtrB	3626861	c.-248C>G	upstream_gene_variant	0.24	rifampicin
mtrB	3626861	c.-248C>G	upstream_gene_variant	0.24	bedaquiline
mtrB	3626866	c.-253T>C	upstream_gene_variant	0.23	rifampicin
mtrB	3626866	c.-253T>C	upstream_gene_variant	0.23	bedaquiline
mtrB	3626876	c.-263A>G	upstream_gene_variant	0.19	rifampicin
mtrB	3626876	c.-263A>G	upstream_gene_variant	0.19	bedaquiline
fbiB	3642098	c.564G>A	synonymous_variant	1.0	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
alr	3840636	p.Pro262Gln	missense_variant	1.0	cycloserine
rpoA	3877494	p.Glu338Asp	missense_variant	0.18	rifampicin	Uncertain significance
rpoA	3877503	p.Ala335Ser	missense_variant	0.18	rifampicin
rpoA	3877506	p.Gly334Ala	missense_variant	0.18	rifampicin
rpoA	3877513	p.Thr332Ser	missense_variant	0.2	rifampicin
rpoA	3877515	c.993G>C	synonymous_variant	0.21	rifampicin
rpoA	3877553	p.Glu319Gln	missense_variant	0.28	rifampicin
rpoA	3877587	c.921A>G	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
rpoA	3877613	p.Ile299Val	missense_variant	0.35	rifampicin
rpoA	3877653	c.855C>T	synonymous_variant	0.16	rifampicin
rpoA	3877656	c.852T>C	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
rpoA	3877737	c.771G>C	synonymous_variant	0.23	rifampicin
rpoA	3877770	c.738A>G	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoA	3877776	c.732T>C	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoA	3877782	c.726T>C	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoA	3877818	c.690A>G	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoA	3877839	c.669G>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoA	3877842	c.666A>G	synonymous_variant	0.28	rifampicin
rpoA	3877857	c.651G>A	synonymous_variant	0.26	rifampicin
rpoA	3877866	c.642G>C	synonymous_variant	0.23	rifampicin
rpoA	3877872	c.636C>T	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoA	3877875	c.633T>G	synonymous_variant	0.19	rifampicin
rpoA	3877893	c.615C>T	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
rpoA	3877900	p.Ser203Asn	missense_variant	0.2	rifampicin
rpoA	3877905	c.603A>G	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoA	3877908	p.Asn200Ser	missense_variant	0.19	rifampicin
rpoA	3877920	c.588G>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoA	3877935	c.573G>A	synonymous_variant	0.23	rifampicin
rpoA	3877962	c.546G>T	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
rpoA	3877986	c.522G>C	synonymous_variant	0.25	rifampicin
rpoA	3877989	c.519A>G	synonymous_variant	0.25	rifampicin	Not assoc w R - Interim
rpoA	3878019	c.489A>G	synonymous_variant	0.18	rifampicin
rpoA	3878022	c.486T>C	synonymous_variant	0.19	rifampicin
rpoA	3878025	c.483C>T	synonymous_variant	0.19	rifampicin
rpoA	3878028	c.480G>C	synonymous_variant	0.2	rifampicin
rpoA	3878031	c.477T>C	synonymous_variant	0.2	rifampicin
rpoA	3878046	c.462T>C	synonymous_variant	0.21	rifampicin
rpoA	3878049	c.459G>C	synonymous_variant	0.21	rifampicin
rpoA	3878055	c.453A>G	synonymous_variant	0.16	rifampicin
rpoA	3878106	c.402G>C	synonymous_variant	0.16	rifampicin
rpoA	3878118	c.390T>C	synonymous_variant	0.21	rifampicin
rpoA	3878130	c.378C>G	synonymous_variant	0.21	rifampicin
rpoA	3878141	p.Met123Leu	missense_variant	0.25	rifampicin	Uncertain significance
rpoA	3878143	p.Gly122Asp	missense_variant	0.28	rifampicin	Uncertain significance
rpoA	3878163	c.345C>T	synonymous_variant	0.34	rifampicin	Not assoc w R - Interim
rpoA	3878169	c.339G>C	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoA	3878184	c.324C>G	synonymous_variant	0.33	rifampicin
rpoA	3878187	c.321C>G	synonymous_variant	0.35	rifampicin
rpoA	3878193	c.315T>C	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoA	3878205	c.303T>C	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoA	3878217	c.291A>G	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
rpoA	3878247	c.261G>C	synonymous_variant	0.37	rifampicin
rpoA	3878271	c.237T>C	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoA	3878276	c.232C>T	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoA	3878284	p.Glu75Ala	missense_variant	0.28	rifampicin
rpoA	3878292	c.216T>C	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoA	3878298	c.210A>G	synonymous_variant	0.24	rifampicin	Not assoc w R - Interim
rpoA	3878304	c.204G>C	synonymous_variant	0.21	rifampicin
rpoA	3878307	c.201C>A	synonymous_variant	0.19	rifampicin
rpoA	3878313	c.195G>C	synonymous_variant	0.18	rifampicin	Not assoc w R - Interim
rpoA	3878322	c.186A>G	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
rpoA	3878364	c.144A>T	synonymous_variant	0.16	rifampicin
rpoA	3878367	c.141C>G	synonymous_variant	0.19	rifampicin
rpoA	3878370	c.138T>C	synonymous_variant	0.19	rifampicin
rpoA	3878376	c.132G>C	synonymous_variant	0.26	rifampicin
rpoA	3878385	c.123C>G	synonymous_variant	0.29	rifampicin
rpoA	3878391	c.117T>C	synonymous_variant	0.33	rifampicin
rpoA	3878396	c.112C>T	synonymous_variant	0.37	rifampicin
rpoA	3878415	c.93C>T	synonymous_variant	0.39	rifampicin
rpoA	3878436	c.72A>G	synonymous_variant	0.35	rifampicin
rpoA	3878442	c.66G>C	synonymous_variant	0.29	rifampicin
rpoA	3878454	c.54A>C	synonymous_variant	0.24	rifampicin
rpoA	3878458	p.Asn17Ser	missense_variant	0.21	rifampicin
rpoA	3878764	c.-257A>G	upstream_gene_variant	0.2	rifampicin
rpoA	3878785	c.-278T>C	upstream_gene_variant	0.19	rifampicin
rpoA	3878788	c.-281G>T	upstream_gene_variant	0.18	rifampicin
rpoA	3878806	c.-299C>G	upstream_gene_variant	0.24	rifampicin
rpoA	3878809	c.-302T>C	upstream_gene_variant	0.25	rifampicin
rpoA	3878824	c.-317G>C	upstream_gene_variant	0.28	rifampicin
rpoA	3878833	c.-326C>G	upstream_gene_variant	0.2	rifampicin
rpoA	3878836	c.-331_-329delAAGinsGGC	upstream_gene_variant	0.2	rifampicin
rpoA	3878853	c.-346G>A	upstream_gene_variant	0.25	rifampicin
rpoA	3878878	c.-371T>C	upstream_gene_variant	0.33	rifampicin	Uncertain significance
rpoA	3878884	c.-377C>G	upstream_gene_variant	0.34	rifampicin
rpoA	3878909	c.-402A>G	upstream_gene_variant	0.32	rifampicin
rpoA	3878914	c.-407T>C	upstream_gene_variant	0.32	rifampicin	Uncertain significance
rpoA	3878917	c.-410G>A	upstream_gene_variant	0.34	rifampicin	Uncertain significance
rpoA	3878935	c.-428C>G	upstream_gene_variant	0.3	rifampicin
rpoA	3878938	c.-431T>G	upstream_gene_variant	0.26	rifampicin
rpoA	3878947	c.-440G>C	upstream_gene_variant	0.26	rifampicin	Uncertain significance
rpoA	3878956	c.-449G>C	upstream_gene_variant	0.24	rifampicin
rpoA	3878962	c.-455G>C	upstream_gene_variant	0.27	rifampicin
rpoA	3878968	c.-461T>C	upstream_gene_variant	0.3	rifampicin	Uncertain significance
rpoA	3878974	c.-469_-467delATCinsGTG	upstream_gene_variant	0.29	rifampicin
rpoA	3878998	c.-491C>G	upstream_gene_variant	0.36	rifampicin	Uncertain significance
rpoA	3879004	c.-499_-497delAAGinsCGC	upstream_gene_variant	0.31	rifampicin
rpoA	3879013	c.-506A>G	upstream_gene_variant	0.37	rifampicin
rpoA	3879028	c.-521C>T	upstream_gene_variant	0.33	rifampicin
rpoA	3879037	c.-530G>C	upstream_gene_variant	0.33	rifampicin
rpoA	3879061	c.-554C>T	upstream_gene_variant	0.3	rifampicin
rpoA	3879079	c.-572A>G	upstream_gene_variant	0.29	rifampicin
rpoA	3879088	c.-581A>C	upstream_gene_variant	0.32	rifampicin
rpoA	3879094	c.-587T>C	upstream_gene_variant	0.3	rifampicin
rpoA	3879121	c.-614T>G	upstream_gene_variant	0.25	rifampicin
rpoA	3879127	c.-620T>C	upstream_gene_variant	0.23	rifampicin
rpoA	3879136	c.-629A>G	upstream_gene_variant	0.2	rifampicin
rpoA	3879154	c.-647T>C	upstream_gene_variant	0.22	rifampicin
rpoA	3879160	c.-653A>G	upstream_gene_variant	0.22	rifampicin
rpoA	3879178	c.-671T>C	upstream_gene_variant	0.27	rifampicin
rpoA	3879190	c.-683C>G	upstream_gene_variant	0.29	rifampicin
rpoA	3879202	c.-695T>C	upstream_gene_variant	0.33	rifampicin
rpoA	3879222	c.-715T>C	upstream_gene_variant	0.3	rifampicin
rpoA	3879226	c.-719G>C	upstream_gene_variant	0.24	rifampicin
rpoA	3879229	c.-722A>G	upstream_gene_variant	0.2	rifampicin
rpoA	3879232	c.-725A>G	upstream_gene_variant	0.2	rifampicin
ddn	3986633	c.-211C>G	upstream_gene_variant	0.23	pretomanid
ddn	3986633	c.-211C>G	upstream_gene_variant	0.23	delamanid
ddn	3986636	c.-208C>G	upstream_gene_variant	0.24	pretomanid
ddn	3986636	c.-208C>G	upstream_gene_variant	0.24	delamanid
ddn	3986648	c.-196C>G	upstream_gene_variant	0.19	pretomanid
ddn	3986648	c.-196C>G	upstream_gene_variant	0.19	delamanid
ddn	3986651	c.-193G>A	upstream_gene_variant	0.17	pretomanid
ddn	3986651	c.-193G>A	upstream_gene_variant	0.17	delamanid
clpC1	4038347	c.2358G>C	synonymous_variant	0.25	pyrazinamide
clpC1	4038356	c.2349T>C	synonymous_variant	0.25	pyrazinamide
clpC1	4038359	c.2346A>G	synonymous_variant	0.23	pyrazinamide
clpC1	4038368	c.2337T>C	synonymous_variant	0.27	pyrazinamide
clpC1	4038388	c.2317T>C	synonymous_variant	0.24	pyrazinamide
clpC1	4038392	c.2313C>T	synonymous_variant	0.24	pyrazinamide
clpC1	4038398	c.2307G>T	synonymous_variant	0.21	pyrazinamide
clpC1	4038403	c.2302T>C	synonymous_variant	0.21	pyrazinamide	Not assoc w R - Interim
clpC1	4038419	c.2286T>C	synonymous_variant	0.18	pyrazinamide
clpC1	4038433	c.2272C>T	synonymous_variant	0.17	pyrazinamide
clpC1	4038587	c.2118C>T	synonymous_variant	0.28	pyrazinamide
clpC1	4038596	c.2109A>G	synonymous_variant	0.29	pyrazinamide
clpC1	4038623	c.2082A>G	synonymous_variant	0.34	pyrazinamide
clpC1	4038640	p.Asp689Asn	missense_variant	0.27	pyrazinamide
clpC1	4038653	c.2052C>T	synonymous_variant	0.2	pyrazinamide
clpC1	4038671	c.2034T>C	synonymous_variant	0.16	pyrazinamide
clpC1	4038740	c.1965G>C	synonymous_variant	0.19	pyrazinamide
clpC1	4038755	c.1950G>T	synonymous_variant	0.24	pyrazinamide
clpC1	4038773	c.1932T>C	synonymous_variant	0.25	pyrazinamide
clpC1	4038782	c.1923G>C	synonymous_variant	0.31	pyrazinamide
clpC1	4038790	c.1915C>T	synonymous_variant	0.32	pyrazinamide	Not assoc w R - Interim
clpC1	4038812	c.1893T>C	synonymous_variant	0.33	pyrazinamide
clpC1	4038815	c.1890G>C	synonymous_variant	0.34	pyrazinamide
clpC1	4038878	c.1827A>G	synonymous_variant	0.4	pyrazinamide	Not assoc w R - Interim
clpC1	4038908	c.1797C>G	synonymous_variant	0.32	pyrazinamide
clpC1	4038914	c.1791G>C	synonymous_variant	0.28	pyrazinamide
clpC1	4038953	c.1752A>G	synonymous_variant	0.23	pyrazinamide
clpC1	4038965	c.1740T>C	synonymous_variant	0.27	pyrazinamide
clpC1	4038971	c.1734T>C	synonymous_variant	0.29	pyrazinamide
clpC1	4038974	c.1731T>C	synonymous_variant	0.29	pyrazinamide	Not assoc w R - Interim
clpC1	4038989	c.1716T>C	synonymous_variant	0.33	pyrazinamide
clpC1	4038997	c.1708T>C	synonymous_variant	0.32	pyrazinamide	Not assoc w R - Interim
clpC1	4039010	c.1695G>C	synonymous_variant	0.34	pyrazinamide
clpC1	4039022	c.1683A>G	synonymous_variant	0.28	pyrazinamide
clpC1	4039025	c.1680C>G	synonymous_variant	0.3	pyrazinamide
clpC1	4039064	c.1641C>T	synonymous_variant	0.3	pyrazinamide
clpC1	4039103	c.1602T>C	synonymous_variant	0.26	pyrazinamide
clpC1	4039106	c.1599G>C	synonymous_variant	0.28	pyrazinamide
clpC1	4039112	c.1593C>G	synonymous_variant	0.31	pyrazinamide
clpC1	4039121	c.1584T>G	synonymous_variant	0.26	pyrazinamide
clpC1	4039133	c.1572C>G	synonymous_variant	0.29	pyrazinamide
clpC1	4039142	c.1563A>G	synonymous_variant	0.29	pyrazinamide
clpC1	4039145	c.1560G>C	synonymous_variant	0.29	pyrazinamide
clpC1	4039169	p.Glu512Asp	missense_variant	0.28	pyrazinamide
clpC1	4039172	c.1533A>G	synonymous_variant	0.27	pyrazinamide
clpC1	4039178	c.1527G>C	synonymous_variant	0.26	pyrazinamide
clpC1	4039183	c.1522T>C	synonymous_variant	0.26	pyrazinamide
clpC1	4039186	c.1519C>T	synonymous_variant	0.26	pyrazinamide
clpC1	4039196	c.1509G>A	synonymous_variant	0.27	pyrazinamide
clpC1	4039199	c.1506C>G	synonymous_variant	0.29	pyrazinamide
clpC1	4039226	c.1479T>C	synonymous_variant	0.23	pyrazinamide	Not assoc w R - Interim
clpC1	4039274	c.1431G>C	synonymous_variant	0.18	pyrazinamide	Not assoc w R - Interim
clpC1	4039364	c.1341C>G	synonymous_variant	0.15	pyrazinamide
clpC1	4039391	c.1314T>G	synonymous_variant	0.23	pyrazinamide
clpC1	4039409	c.1296T>C	synonymous_variant	0.22	pyrazinamide
clpC1	4039412	c.1293T>G	synonymous_variant	0.22	pyrazinamide
clpC1	4039430	c.1275T>C	synonymous_variant	0.2	pyrazinamide
clpC1	4039442	c.1263A>G	synonymous_variant	0.17	pyrazinamide
clpC1	4039508	c.1197G>C	synonymous_variant	0.25	pyrazinamide
clpC1	4039556	c.1149G>C	synonymous_variant	0.28	pyrazinamide
clpC1	4039574	p.Ala377Gly	missense_variant	0.25	pyrazinamide
clpC1	4039577	c.1128T>C	synonymous_variant	0.26	pyrazinamide	Not assoc w R - Interim
clpC1	4039616	c.1089G>C	synonymous_variant	0.34	pyrazinamide
clpC1	4039622	c.1083C>T	synonymous_variant	0.36	pyrazinamide
clpC1	4039661	c.1044T>C	synonymous_variant	0.4	pyrazinamide
clpC1	4039724	c.981A>G	synonymous_variant	0.27	pyrazinamide
clpC1	4039826	c.879C>G	synonymous_variant	0.15	pyrazinamide
clpC1	4039831	c.874T>C	synonymous_variant	0.17	pyrazinamide
clpC1	4039850	c.855T>C	synonymous_variant	0.23	pyrazinamide
clpC1	4039865	c.840T>C	synonymous_variant	0.28	pyrazinamide
clpC1	4039898	c.807C>G	synonymous_variant	0.28	pyrazinamide
clpC1	4039904	c.801A>G	synonymous_variant	0.32	pyrazinamide
clpC1	4039931	c.774T>C	synonymous_variant	0.33	pyrazinamide
clpC1	4039946	c.759A>T	synonymous_variant	0.31	pyrazinamide
clpC1	4039952	c.753T>C	synonymous_variant	0.31	pyrazinamide
clpC1	4039979	c.726C>G	synonymous_variant	0.26	pyrazinamide
clpC1	4039991	c.714G>T	synonymous_variant	0.25	pyrazinamide
clpC1	4039996	p.Glu237Gln	missense_variant	0.22	pyrazinamide
clpC1	4040009	c.696C>G	synonymous_variant	0.24	pyrazinamide
clpC1	4040021	c.684A>C	synonymous_variant	0.21	pyrazinamide	Not assoc w R - Interim
clpC1	4040024	c.681A>G	synonymous_variant	0.2	pyrazinamide
clpC1	4040027	c.678C>T	synonymous_variant	0.2	pyrazinamide
clpC1	4040030	c.675C>G	synonymous_variant	0.2	pyrazinamide
clpC1	4040033	c.672G>C	synonymous_variant	0.22	pyrazinamide
clpC1	4040042	c.663C>T	synonymous_variant	0.25	pyrazinamide	Not assoc w R - Interim
clpC1	4040048	c.657C>T	synonymous_variant	0.26	pyrazinamide	Not assoc w R - Interim
clpC1	4040090	c.613_615delTCTinsAGC	synonymous_variant	0.2	pyrazinamide
clpC1	4040093	c.612C>G	synonymous_variant	0.21	pyrazinamide	Not assoc w R - Interim
clpC1	4040105	c.600C>G	synonymous_variant	0.26	pyrazinamide
clpC1	4040144	c.561G>C	synonymous_variant	0.19	pyrazinamide
clpC1	4040147	c.558A>G	synonymous_variant	0.19	pyrazinamide	Not assoc w R - Interim
clpC1	4040153	c.552A>G	synonymous_variant	0.17	pyrazinamide
clpC1	4040162	c.543G>C	synonymous_variant	0.16	pyrazinamide	Not assoc w R - Interim
clpC1	4040171	c.534C>G	synonymous_variant	0.16	pyrazinamide
clpC1	4040237	c.468C>T	synonymous_variant	0.22	pyrazinamide
clpC1	4040249	c.456A>G	synonymous_variant	0.27	pyrazinamide
clpC1	4040252	c.453C>G	synonymous_variant	0.28	pyrazinamide
clpC1	4040267	c.438A>G	synonymous_variant	0.25	pyrazinamide	Not assoc w R - Interim
clpC1	4040273	c.432T>A	synonymous_variant	0.24	pyrazinamide
clpC1	4040277	c.427_428delTCinsAG	synonymous_variant	0.23	pyrazinamide
clpC1	4040279	c.426C>G	synonymous_variant	0.22	pyrazinamide	Not assoc w R - Interim
clpC1	4040330	c.375C>G	synonymous_variant	0.21	pyrazinamide
clpC1	4040342	c.363C>G	synonymous_variant	0.19	pyrazinamide
clpC1	4040345	c.360C>G	synonymous_variant	0.2	pyrazinamide
clpC1	4040354	c.351A>G	synonymous_variant	0.2	pyrazinamide
clpC1	4040357	c.348T>C	synonymous_variant	0.21	pyrazinamide
clpC1	4040363	c.342A>C	synonymous_variant	0.18	pyrazinamide
clpC1	4040369	c.336C>G	synonymous_variant	0.17	pyrazinamide
clpC1	4040480	c.225T>G	synonymous_variant	0.17	pyrazinamide
clpC1	4040486	c.219G>C	synonymous_variant	0.18	pyrazinamide
clpC1	4040522	c.183T>C	synonymous_variant	0.16	pyrazinamide	Not assoc w R - Interim
clpC1	4040528	c.177G>T	synonymous_variant	0.16	pyrazinamide
clpC1	4040531	c.174T>C	synonymous_variant	0.16	pyrazinamide
clpC1	4040534	c.171A>G	synonymous_variant	0.16	pyrazinamide	Not assoc w R - Interim
clpC1	4040537	c.168G>C	synonymous_variant	0.16	pyrazinamide
clpC1	4040546	c.159G>C	synonymous_variant	0.16	pyrazinamide
glpK	4138580	c.1176C>T	synonymous_variant	0.19	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138601	c.1155G>C	synonymous_variant	0.21	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138606	c.1150T>C	synonymous_variant	0.21	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138607	c.1149G>C	synonymous_variant	0.2	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138610	c.1146C>G	synonymous_variant	0.2	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138634	c.1122G>A	synonymous_variant	0.17	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4138643	c.1113A>C	synonymous_variant	0.15	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138714	p.Ala348Ser	missense_variant	0.16	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138715	c.1041G>A	synonymous_variant	0.16	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138718	c.1038T>C	synonymous_variant	0.18	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138721	c.1035G>A	synonymous_variant	0.17	levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4138724	c.1032A>G	synonymous_variant	0.17	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138730	c.1026C>T	synonymous_variant	0.2	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138757	c.999A>G	synonymous_variant	0.23	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138769	c.987G>C	synonymous_variant	0.16	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139198	c.558C>G	synonymous_variant	0.18	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4139204	c.552G>C	synonymous_variant	0.19	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139207	c.549T>C	synonymous_variant	0.18	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139581	p.Asn59Asp	missense_variant	0.25	levofloxacin	Uncertain significance
					moxifloxacin	Uncertain significance
					isoniazid	Uncertain significance
					streptomycin	Uncertain significance
					rifampicin	Uncertain significance
					ethambutol	Uncertain significance
glpK	4139627	c.129G>A	synonymous_variant	0.35	levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4139630	c.126C>T	synonymous_variant	0.35	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139636	c.120C>G	synonymous_variant	0.33	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139642	c.114G>A	synonymous_variant	0.35	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139651	p.His35Glu	missense_variant	0.3	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
embC	4239344	c.-519G>C	upstream_gene_variant	0.17	ethambutol
embC	4239350	c.-513G>C	upstream_gene_variant	0.16	ethambutol
embC	4240657	c.795G>C	synonymous_variant	0.18	ethambutol
embC	4240660	c.798C>T	synonymous_variant	0.17	ethambutol
embC	4240671	p.Thr270Ile	missense_variant	0.18	ethambutol	Not assoc w R
embC	4240678	c.816T>G	synonymous_variant	0.19	ethambutol
embC	4240685	p.Thr275Ala	missense_variant	0.2	ethambutol
embC	4240693	c.831T>C	synonymous_variant	0.25	ethambutol
embC	4240698	p.Ala279Gly	missense_variant	0.26	ethambutol
embC	4240726	c.864G>C	synonymous_variant	0.32	ethambutol	Not assoc w R - Interim
embC	4240780	c.918T>C	synonymous_variant	0.26	ethambutol
embC	4240783	c.921G>C	synonymous_variant	0.28	ethambutol
embC	4240789	c.927T>C	synonymous_variant	0.29	ethambutol
embC	4240807	c.945C>T	synonymous_variant	0.32	ethambutol	Not assoc w R - Interim
embC	4240819	c.957A>G	synonymous_variant	0.33	ethambutol
embC	4240831	c.969T>G	synonymous_variant	0.31	ethambutol
embC	4240859	p.Leu333Val	missense_variant	0.36	ethambutol
embC	4240867	c.1005T>C	synonymous_variant	0.33	ethambutol
embC	4240879	c.1017G>C	synonymous_variant	0.3	ethambutol
embC	4240880	p.Ala340Thr	missense_variant	0.29	ethambutol	Uncertain significance
embC	4240885	c.1023T>C	synonymous_variant	0.27	ethambutol
embC	4240897	c.1035C>G	synonymous_variant	0.25	ethambutol	Not assoc w R
embC	4240898	c.1036_1038delCTAinsTTG	synonymous_variant	0.24	ethambutol
embC	4240921	c.1059C>G	synonymous_variant	0.18	ethambutol
embC	4240924	c.1062C>G	synonymous_variant	0.17	ethambutol
embC	4240966	c.1104G>C	synonymous_variant	0.16	ethambutol
embC	4240978	c.1116G>A	synonymous_variant	0.15	ethambutol	Not assoc w R - Interim
embC	4240980	p.Thr373Lys	missense_variant	0.15	ethambutol
embC	4240983	p.Ser374Asn	missense_variant	0.16	ethambutol
embC	4240990	c.1128A>C	synonymous_variant	0.18	ethambutol
embC	4241017	c.1155T>C	synonymous_variant	0.29	ethambutol
embC	4241020	c.1158G>C	synonymous_variant	0.26	ethambutol
embC	4241023	c.1161T>G	synonymous_variant	0.24	ethambutol
embC	4241038	c.1176G>C	synonymous_variant	0.22	ethambutol
embC	4241053	c.1191G>C	synonymous_variant	0.16	ethambutol
embC	4241107	c.1245G>C	synonymous_variant	0.28	ethambutol
embC	4241129	c.1267C>T	synonymous_variant	0.3	ethambutol
embC	4241140	c.1278A>G	synonymous_variant	0.27	ethambutol	Not assoc w R - Interim
embC	4241158	c.1296T>C	synonymous_variant	0.22	ethambutol
embC	4241161	c.1299C>T	synonymous_variant	0.19	ethambutol
embC	4241162	c.1300T>C	synonymous_variant	0.19	ethambutol
embC	4241407	c.1545A>G	synonymous_variant	0.18	ethambutol
embC	4241411	p.Ile517Leu	missense_variant	0.2	ethambutol
embC	4241449	c.1587C>G	synonymous_variant	0.26	ethambutol
embC	4241452	c.1590G>C	synonymous_variant	0.25	ethambutol
embC	4241453	p.Ile531Val	missense_variant	0.26	ethambutol
embC	4242075	p.Arg738Gln	missense_variant	0.95	ethambutol	Not assoc w R
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4245093	p.Ile621Val	missense_variant	0.17	ethambutol	Uncertain significance
embA	4245101	c.1869G>C	synonymous_variant	0.2	ethambutol
embA	4245137	c.1905T>C	synonymous_variant	0.17	ethambutol
embA	4245143	c.1911C>T	synonymous_variant	0.17	ethambutol
embA	4245883	p.Gly884Asp	missense_variant	0.96	ethambutol	Uncertain significance
embB	4246004	c.-510T>C	upstream_gene_variant	0.16	ethambutol
embA	4246011	p.Phe927Ile	missense_variant	0.17	ethambutol
embA	4246020	p.Ala930Thr	missense_variant	0.17	ethambutol
embB	4246040	c.-474C>G	upstream_gene_variant	0.17	ethambutol
embA	4246041	p.Asp937Asn	missense_variant	0.17	ethambutol
embA	4246331	c.3099C>T	synonymous_variant	0.25	ethambutol	Not assoc w R - Interim
embA	4246338	p.Leu1036Met	missense_variant	0.26	ethambutol
embB	4246361	c.-153C>G	upstream_gene_variant	0.32	ethambutol
embA	4246383	p.Tyr1051His	missense_variant	0.35	ethambutol
embB	4246400	c.-114G>C	upstream_gene_variant	0.26	ethambutol
embB	4246403	c.-111G>C	upstream_gene_variant	0.24	ethambutol
embA	4246413	p.His1061Phe	missense_variant	0.17	ethambutol
embA	4246419	c.3187C>T	synonymous_variant	0.17	ethambutol	Not assoc w R - Interim
embB	4246430	c.-84C>T	upstream_gene_variant	0.14	ethambutol
embB	4247395	c.882C>G	synonymous_variant	0.17	ethambutol
embB	4247401	c.888T>C	synonymous_variant	0.22	ethambutol
embB	4247437	c.924A>C	synonymous_variant	0.31	ethambutol
embB	4247464	c.951C>G	synonymous_variant	0.36	ethambutol
embB	4247470	c.957T>C	synonymous_variant	0.33	ethambutol
embB	4247476	c.963C>T	synonymous_variant	0.33	ethambutol
embB	4247491	c.978G>C	synonymous_variant	0.29	ethambutol
embB	4247497	c.984T>C	synonymous_variant	0.27	ethambutol
embB	4247512	c.999T>C	synonymous_variant	0.26	ethambutol
embB	4247544	p.Ser344Thr	missense_variant	0.19	ethambutol
embB	4247554	c.1041T>C	synonymous_variant	0.18	ethambutol
embB	4247797	c.1284C>G	synonymous_variant	0.14	ethambutol
embB	4247803	c.1290G>C	synonymous_variant	0.2	ethambutol
embB	4247815	c.1302C>G	synonymous_variant	0.25	ethambutol
embB	4247819	p.Val436Ile	missense_variant	0.25	ethambutol	Uncertain significance
embB	4247830	c.1317A>G	synonymous_variant	0.31	ethambutol	Not assoc w R - Interim
embB	4247836	c.1323A>C	synonymous_variant	0.29	ethambutol	Not assoc w R - Interim
embB	4247839	c.1326G>T	synonymous_variant	0.3	ethambutol
embB	4247842	c.1329T>C	synonymous_variant	0.3	ethambutol
embB	4247857	c.1344C>A	synonymous_variant	0.34	ethambutol
embB	4247881	c.1368G>C	synonymous_variant	0.33	ethambutol
embB	4247887	c.1374C>T	synonymous_variant	0.28	ethambutol	Not assoc w R - Interim
embB	4247893	c.1380C>T	synonymous_variant	0.25	ethambutol
embB	4247899	p.Met462Ile	missense_variant	0.23	ethambutol
embB	4247905	c.1392G>C	synonymous_variant	0.17	ethambutol	Not assoc w R - Interim
embB	4247908	c.1395C>T	synonymous_variant	0.18	ethambutol
embB	4247914	c.1401G>C	synonymous_variant	0.21	ethambutol	Not assoc w R - Interim
embB	4247920	c.1407T>C	synonymous_variant	0.21	ethambutol
embB	4247923	c.1410T>C	synonymous_variant	0.23	ethambutol
embB	4247940	p.Leu476Trp	missense_variant	0.27	ethambutol
embB	4247945	c.1432T>C	synonymous_variant	0.22	ethambutol
embB	4247951	p.Ser480Ala	missense_variant	0.21	ethambutol
embB	4247974	c.1461C>G	synonymous_variant	0.23	ethambutol
embB	4247980	c.1467C>A	synonymous_variant	0.23	ethambutol
embB	4248007	c.1494C>G	synonymous_variant	0.22	ethambutol
embB	4248035	p.Val508Ile	missense_variant	0.14	ethambutol
embB	4248041	p.Ala510Thr	missense_variant	0.14	ethambutol	Uncertain significance
embB	4248064	c.1551G>C	synonymous_variant	0.16	ethambutol	Not assoc w R - Interim
embB	4248070	c.1557T>C	synonymous_variant	0.16	ethambutol
embB	4248226	c.1713G>C	synonymous_variant	0.23	ethambutol
embB	4248277	c.1764G>C	synonymous_variant	0.33	ethambutol
embB	4248316	c.1803C>G	synonymous_variant	0.19	ethambutol
embB	4248319	c.1806A>G	synonymous_variant	0.18	ethambutol
embB	4248322	c.1809G>A	synonymous_variant	0.18	ethambutol	Not assoc w R - Interim
aftB	4267577	c.1260C>T	synonymous_variant	0.17	ethambutol	Not assoc w R - Interim
aftB	4267580	c.1257G>C	synonymous_variant	0.19	ethambutol
aftB	4267607	c.1230G>A	synonymous_variant	0.26	ethambutol
aftB	4267622	c.1215G>C	synonymous_variant	0.24	ethambutol
aftB	4267625	c.1212T>C	synonymous_variant	0.24	ethambutol
aftB	4267634	p.Arg401His	missense_variant	0.21	ethambutol
aftB	4267649	c.1188T>C	synonymous_variant	0.19	ethambutol	Not assoc w R - Interim
aftB	4269027	c.-191C>A	upstream_gene_variant	0.15	ethambutol
aftB	4269033	c.-197T>C	upstream_gene_variant	0.16	ethambutol
aftB	4269036	c.-200C>G	upstream_gene_variant	0.16	ethambutol
aftB	4269042	c.-206G>C	upstream_gene_variant	0.15	ethambutol
aftB	4269123	c.-287T>A	upstream_gene_variant	0.15	ethambutol
aftB	4269132	c.-296G>C	upstream_gene_variant	0.17	ethambutol
ubiA	4269141	p.Leu231Ile	missense_variant	0.2	ethambutol
ubiA	4269144	c.690C>G	synonymous_variant	0.2	ethambutol	Not assoc w R - Interim
ubiA	4269164	p.Leu224Met	missense_variant	0.2	ethambutol
aftB	4269177	c.-341G>C	upstream_gene_variant	0.2	ethambutol
ethA	4326230	p.Asp415Gly	missense_variant	1.0	ethionamide	Uncertain significance
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
whiB6	4338732	c.-211C>T	upstream_gene_variant	1.0	kanamycin
					capreomycin
					amikacin
gid	4407588	c.615A>G	synonymous_variant	1.0	streptomycin	Not assoc w R

TB-Profiler result