TB-Profiler result

Run: ERR4797588
Summary

Run ID: ERR4797588

Sample name:

Date: 2024-10-04T01:50:17.774516

Number of reads: 3648035

Percentage reads mapped: 75.47

Median coverage: 95.0

Strain: lineage3

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Asp435Val Assoc w R
isoniazid katG p.Ala172Thr Uncertain significance Mutation from literature
ethambutol embB p.His312Arg Mutation from literature
p.Leu359Ile Uncertain significance Mutation from literature
p.Asp1024Asn Uncertain significance Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761110 p.Asp435Val missense_variant 0.77 rifampicin Assoc w R
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance Mutation from literature
katG 2155598 p.Ala172Thr missense_variant 1.0 isoniazid Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.18 ethambutol Mutation from literature
embB 4247588 p.Leu359Ile missense_variant 0.16 ethambutol Uncertain significance Mutation from literature
embB 4249583 p.Asp1024Asn missense_variant 0.88 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 30 c.30C>G synonymous_variant 0.17 isoniazid
dnaA 42 c.42C>T synonymous_variant 0.14 isoniazid
dnaA 558 c.558G>C synonymous_variant 0.17 isoniazid
dnaA 561 c.561C>T synonymous_variant 0.17 isoniazid
dnaA 567 c.567C>G synonymous_variant 0.17 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.17 isoniazid
dnaA 600 c.600T>A synonymous_variant 0.19 isoniazid
dnaA 612 c.612G>C synonymous_variant 0.21 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.27 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 649 c.649C>T synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.25 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.25 isoniazid
dnaA 669 c.669C>T synonymous_variant 0.24 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.21 isoniazid
dnaA 682 c.682T>C synonymous_variant 0.22 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.22 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.23 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.26 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.24 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.22 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.21 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.2 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.2 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.21 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCTC synonymous_variant 0.26 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.25 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.25 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.25 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.27 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.25 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.25 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.22 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.23 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.17 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.19 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.19 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.2 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.2 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.21 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.21 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.21 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.2 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.2 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.17 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>G synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.24 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.25 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.24 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.28 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.27 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.26 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.23 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.2 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.19 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1104 c.1104T>C synonymous_variant 0.15 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.16 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.18 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.24 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.27 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.27 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.28 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.27 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.22 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.22 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.21 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.21 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1311 c.1311C>G synonymous_variant 0.22 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.22 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.22 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.22 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.25 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.25 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.22 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.2 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.17 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.18 isoniazid
gyrB 6238 c.999G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.19 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6628 c.-674C>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.2 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6973 c.-329G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7124 p.Ser629Thr missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7228 c.-74C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 7234 c.1995C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7442 c.141G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCTC synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7725 c.424C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7739 c.438C>T synonymous_variant 0.27 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7763 c.462T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8579 p.Asp426Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8708 c.1407G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.17 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9158 c.1857C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 c.2007C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9312 c.2011C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9317 c.2016G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
Rv0010c 13905 c.-347G>T upstream_gene_variant 0.91 isoniazid
fgd1 490797 c.15G>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490800 c.18A>C synonymous_variant 0.17 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 490803 c.21T>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490812 c.30A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 490815 c.33G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 490827 c.45C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 490848 c.66A>G synonymous_variant 0.28 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 490868 p.Ala29Gly missense_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 490887 c.105G>A synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 490890 c.108C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 490896 c.114C>T synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 490905 c.123T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 490911 c.129T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 490917 c.135C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490921 p.Gln47Glu missense_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490929 c.147C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490932 c.150T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490935 c.153C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490948 p.Ser56Ala missense_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490962 c.180T>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490984 p.Leu68Ile missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 490987 p.Leu69Met missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 490998 c.216T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491001 c.219G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491007 c.225G>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 491013 c.231C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491043 c.261T>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491049 c.267T>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491063 p.Gly94Ala missense_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491077 p.Asn99Asp missense_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 491082 c.300T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fgd1 491083 p.Val101Ile missense_variant 0.31 pretomanid
delamanid
clofazimine
fgd1 491091 c.309T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 491094 c.312C>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 491097 c.315G>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fgd1 491100 c.318C>T synonymous_variant 0.31 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491106 c.324T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fgd1 491121 c.339A>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fgd1 491130 c.348C>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 491144 p.Ala121Asp missense_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491151 c.369G>A synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 491173 c.391C>A synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491181 c.399T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491184 c.402A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491191 p.Gly137Arg missense_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491194 c.412_414delCTAinsTTG synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491202 c.420G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491203 p.Gln141Glu missense_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Arg missense_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491244 c.462T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 491302 p.Ile174Val missense_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491307 c.525C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491337 c.555C>G synonymous_variant 0.17 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491349 c.567T>C synonymous_variant 0.17 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491601 c.819T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491620 p.Ile280Val missense_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491643 c.861G>A synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491646 c.864G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491649 c.867C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491658 c.876A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491661 c.879C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491673 c.891A>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491676 c.894T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491679 c.897A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575821 c.474G>C synonymous_variant 0.18 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.17 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.19 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.2 isoniazid
ethionamide
ccsA 620295 c.405G>T synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620310 c.420C>T synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620346 c.456C>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620389 c.499C>T synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.18 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620424 c.534G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620682 c.792G>A synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620718 c.828G>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657231 p.Ile80Val missense_variant 0.19 ethionamide
Rv0565c 657237 c.234A>G synonymous_variant 0.21 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.22 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.22 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.21 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.21 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.21 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.21 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.19 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.2 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.21 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.21 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.21 ethionamide
Rv0565c 657348 c.123A>G synonymous_variant 0.21 ethionamide
Rv0565c 657356 p.Ile39Val missense_variant 0.22 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.17 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.19 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.22 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.2 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.19 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.2 ethionamide
hadA 731732 c.-198G>A upstream_gene_variant 0.18 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.2 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.16 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.16 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.22 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.24 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.25 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.27 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.3 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.29 isoniazid
nusG 734421 c.168A>G synonymous_variant 0.18 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.18 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.21 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.23 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.24 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.22 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.2 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.19 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 759746 c.-61C>T upstream_gene_variant 0.98 rifampicin Not assoc w R
rpoB 760139 c.333A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.2 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.24 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.36 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.35 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.35 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.36 rifampicin
rpoB 760343 c.537G>C synonymous_variant 0.35 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.29 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.27 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.22 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.31 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243His missense_variant 0.3 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.31 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.3 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.3 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.29 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.22 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.17 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.17 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.17 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.18 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.18 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.27 rifampicin
rpoB 760991 c.1185G>C synonymous_variant 0.28 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.24 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.24 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.24 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.29 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.31 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.29 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.22 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.24 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.2 rifampicin
rpoB 761373 p.Val523His missense_variant 0.2 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.22 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.21 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.21 rifampicin
rpoB 761439 p.Asp545Ser missense_variant 0.21 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.24 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.23 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.23 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.26 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.3 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.28 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.3 rifampicin
rpoB 761504 c.1698C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.31 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.36 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.22 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761689 p.Ala628Glu missense_variant 0.81 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.16 rifampicin
rpoB 761834 c.2028T>G synonymous_variant 0.17 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.17 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.21 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.2 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.2 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.19 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.17 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.19 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.18 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.18 rifampicin
rpoB 761999 c.2193G>C synonymous_variant 0.17 rifampicin
rpoB 762065 c.2259T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.18 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.2 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.2 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.21 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.2 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762248 c.2442G>C synonymous_variant 0.25 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.25 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.23 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.23 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.2 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.2 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.17 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.18 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.18 rifampicin
rpoC 762389 c.-981G>A upstream_gene_variant 0.17 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.22 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 0.99 rifampicin Not assoc w R
rpoC 762446 c.-924C>G upstream_gene_variant 0.23 rifampicin
rpoB 762486 p.Pro894Ala missense_variant 0.2 rifampicin
rpoB 762489 p.Val895Gln missense_variant 0.19 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.18 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.18 rifampicin Uncertain significance
rpoC 762521 c.-849C>G upstream_gene_variant 0.2 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.17 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.17 rifampicin
rpoB 762789 p.Leu995Met missense_variant 0.17 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.25 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.28 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763034 c.-336C>A upstream_gene_variant 0.26 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.28 rifampicin
rpoC 763187 c.-183C>G upstream_gene_variant 0.27 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.27 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.24 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.2 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763504 c.135C>G synonymous_variant 0.28 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>G synonymous_variant 0.36 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.4 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.39 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.38 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.36 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.36 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.35 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.36 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.38 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.36 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.35 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.35 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.3 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.27 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.26 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.28 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.3 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.31 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.33 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.31 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.33 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.39 rifampicin
rpoC 763951 c.582G>T synonymous_variant 0.36 rifampicin
rpoC 763960 c.591T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763991 p.Ile208Leu missense_variant 0.43 rifampicin
rpoC 763996 c.627T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764005 c.636G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.44 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.45 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.43 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.4 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.4 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.42 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.43 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.41 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.4 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.39 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.4 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.37 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.38 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.4 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.4 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>G synonymous_variant 0.44 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.22 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.29 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.28 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.28 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.3 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.33 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.36 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.49 rifampicin
rpoC 764585 c.1216_1218delCTCinsTTG synonymous_variant 0.43 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.4 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>G synonymous_variant 0.31 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 0.29 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764815 c.1446A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.26 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.28 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.27 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.2 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>G synonymous_variant 0.18 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765412 c.2043T>C synonymous_variant 0.17 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.36 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.35 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.35 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.33 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.32 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.26 rifampicin
rpoC 765752 p.Asp795Ser missense_variant 0.25 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.31 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.27 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.28 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.28 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.29 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.25 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.27 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.24 rifampicin
rpoC 766061 p.Val898Leu missense_variant 0.2 rifampicin
rpoC 766081 c.2712T>C synonymous_variant 0.18 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.18 rifampicin
rpoC 766258 c.2889T>C synonymous_variant 0.2 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.23 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.23 rifampicin
rpoC 766279 c.2910C>G synonymous_variant 0.22 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.22 rifampicin
rpoC 766300 c.2931C>G synonymous_variant 0.27 rifampicin
rpoC 766312 c.2943T>G synonymous_variant 0.28 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.28 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.27 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.28 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.28 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.28 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.25 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.28 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766393 c.3024C>G synonymous_variant 0.31 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.33 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.37 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.37 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.34 rifampicin
rpoC 766471 c.3102G>C synonymous_variant 0.32 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.33 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.34 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.32 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.33 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.32 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.28 rifampicin
rpoC 766579 c.3210C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>G synonymous_variant 0.25 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.25 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.24 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.24 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.28 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.22 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.24 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.28 rifampicin
rpoC 766651 c.3282T>G synonymous_variant 0.27 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.24 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.22 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.23 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.18 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.19 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.21 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.28 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.41 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.44 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.45 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.45 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.46 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.42 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.42 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.32 rifampicin
rpoC 767152 c.3783T>G synonymous_variant 0.36 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.28 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.35 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.2 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.18 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.17 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.17 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.17 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.31 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.3 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.34 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.33 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.34 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.33 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.31 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.31 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.28 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.26 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.27 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.26 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.25 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.2 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.19 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.18 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.24 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.25 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.26 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.24 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.23 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.23 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.24 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.24 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.25 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.26 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.3 streptomycin Uncertain significance
rplC 800567 c.-242A>G upstream_gene_variant 0.2 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.22 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.25 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.25 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.26 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.4 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.36 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.35 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.34 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.36 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.35 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.36 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.3 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.29 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.2 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.2 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.21 linezolid
rplC 800814 c.6A>G synonymous_variant 0.21 linezolid
rplC 800817 c.9A>T synonymous_variant 0.19 linezolid
rplC 800844 c.36T>C synonymous_variant 0.24 linezolid
rplC 800865 c.57A>G synonymous_variant 0.18 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.18 linezolid
rplC 800875 p.Val23Ile missense_variant 0.16 linezolid
rplC 800880 c.72A>G synonymous_variant 0.16 linezolid
rplC 800889 c.81C>G synonymous_variant 0.18 linezolid
rplC 800892 c.84G>C synonymous_variant 0.19 linezolid
rplC 800907 c.99C>G synonymous_variant 0.16 linezolid
rplC 800916 c.108A>G synonymous_variant 0.16 linezolid
rplC 800939 p.Arg44His missense_variant 0.15 linezolid
rplC 800967 c.159C>G synonymous_variant 0.16 linezolid
rplC 800970 c.162T>C synonymous_variant 0.17 linezolid Not assoc w R - Interim
rplC 801195 c.387G>C synonymous_variant 0.17 linezolid
rplC 801207 c.399C>T synonymous_variant 0.17 linezolid
rplC 801246 c.438C>T synonymous_variant 0.19 linezolid
rplC 801249 c.441T>C synonymous_variant 0.18 linezolid
rplC 801255 c.447C>T synonymous_variant 0.17 linezolid
rplC 801264 c.456C>T synonymous_variant 0.17 linezolid
rplC 801267 c.459A>T synonymous_variant 0.17 linezolid
rplC 801270 c.462T>C synonymous_variant 0.17 linezolid
rplC 801276 c.468G>C synonymous_variant 0.17 linezolid
rplC 801300 c.492C>G synonymous_variant 0.2 linezolid
rplC 801309 c.501C>G synonymous_variant 0.22 linezolid
rplC 801312 c.504G>C synonymous_variant 0.22 linezolid
rplC 801321 c.513C>T synonymous_variant 0.23 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.22 linezolid
rplC 801339 c.531T>C synonymous_variant 0.19 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.19 linezolid
rplC 801348 c.540T>G synonymous_variant 0.2 linezolid
rplC 801357 c.549T>C synonymous_variant 0.22 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.23 linezolid
rplC 801402 c.594T>C synonymous_variant 0.21 linezolid
rplC 801405 c.597T>C synonymous_variant 0.21 linezolid
rplC 801423 c.615G>C synonymous_variant 0.18 linezolid
rplC 801426 c.618C>G synonymous_variant 0.17 linezolid
rplC 801427 p.Met207Val missense_variant 0.17 linezolid
rplC 801438 c.630T>C synonymous_variant 0.18 linezolid
rplC 801442 p.Ile212Val missense_variant 0.19 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303708 c.778T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303797 c.867A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303866 p.Glu312Asp missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304727 c.1797A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.27 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1305006 c.2076A>G synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1305012 c.2082G>C synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>G synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1305030 c.2100G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1305033 c.2103T>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1305042 c.2112A>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1305063 c.2133G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1305066 c.2136T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1305069 c.2139G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305075 c.2145T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1305078 c.2148A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
atpE 1461089 c.45G>C synonymous_variant 0.21 bedaquiline
atpE 1461097 p.Ala18Gly missense_variant 0.2 bedaquiline
atpE 1461101 c.57T>C synonymous_variant 0.2 bedaquiline
atpE 1461107 c.63C>G synonymous_variant 0.19 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.25 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.3 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.31 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.31 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.31 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.31 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.3 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.28 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.27 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.3 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.18 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474044 n.387C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476717 n.3060C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
inhA 1673568 c.-634C>G upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673574 c.-628C>G upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673580 c.-622T>G upstream_gene_variant 0.22 isoniazid Uncertain significance
ethionamide
inhA 1673589 c.-613A>G upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673591 c.-611C>T upstream_gene_variant 0.18 isoniazid Uncertain significance
ethionamide
inhA 1673596 c.-606A>G upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673602 c.-600C>T upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673607 c.-595T>C upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673615 c.-587_-586delAAinsTG upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673619 c.-583T>C upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673633 c.-569G>A upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1673637 c.-565C>G upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673641 c.-561G>A upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673955 c.-247G>C upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673961 c.-241A>C upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673985 c.-217C>A upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1674006 c.-196T>G upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1674018 c.-184G>C upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1674021 c.-181G>C upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1674024 c.-178T>C upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1674033 c.-169T>C upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1674037 c.-165_-164delCAinsGC upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1674042 c.-160G>T upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1674049 c.-153_-151delCAAinsGAC upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1674054 c.-148T>C upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1674060 c.-142A>G upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1674063 c.-139G>C upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1674079 c.-123C>G upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674870 c.669T>C synonymous_variant 0.17 isoniazid
ethionamide
rpsA 1833568 c.27G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.16 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.29 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.38 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.42 pyrazinamide
rpsA 1833877 c.336C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.43 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.39 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834096 c.555G>T synonymous_variant 0.19 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.2 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.33 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.23 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.17 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.18 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.17 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.23 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.2 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.22 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.2 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.21 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.2 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.18 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.17 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064912 c.-184A>G upstream_gene_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064915 c.-187G>C upstream_gene_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064936 c.-208C>G upstream_gene_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064942 c.-214G>A upstream_gene_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101912 c.1131G>C synonymous_variant 0.19 isoniazid
delamanid
ethionamide
ndh 2101920 c.1123A>C synonymous_variant 0.17 isoniazid
delamanid
ethionamide
ndh 2101924 c.1119T>G synonymous_variant 0.18 isoniazid
delamanid
ethionamide
ndh 2101939 c.1104A>G synonymous_variant 0.19 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155691 c.421T>C synonymous_variant 0.19 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.21 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.23 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.23 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.23 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.23 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.23 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.23 isoniazid
katG 2155785 c.327T>C synonymous_variant 0.17 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2169599 p.Asn338Lys missense_variant 1.0 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289047 c.195C>T synonymous_variant 0.99 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.19 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.16 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.17 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.21 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.2 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.18 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.17 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.16 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.17 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.17 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.2 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.18 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.18 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.21 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.18 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.18 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.18 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.18 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.18 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.22 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.21 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.19 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.17 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 0.99 isoniazid Not assoc w R
ahpC 2726116 c.-77T>G upstream_gene_variant 1.0 isoniazid Uncertain significance
ahpC 2726579 c.387T>C synonymous_variant 0.19 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.24 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.24 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.24 isoniazid
ahpC 2726601 p.Ile137Leu missense_variant 0.25 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.19 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.19 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
folC 2747314 c.285A>C synonymous_variant 0.17 para-aminosalicylic_acid
Rv2477c 2782498 c.1545C>T synonymous_variant 0.99 kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R
Rv2477c 2782861 c.1182T>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.15 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782894 c.1149C>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.34 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.29 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.35 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.27 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.28 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.28 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.27 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783572 c.471A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783602 c.441G>A synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.25 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784414 c.-372A>G upstream_gene_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3065979 c.213T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065988 c.204A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065993 p.Val67Ile missense_variant 0.21 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3066002 p.Met64Leu missense_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066003 c.189C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid
rifampicin
ethambutol
Rv2752c 3066009 c.183G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066018 c.174T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066024 c.168T>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066066 c.126T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067249 p.Thr233Ser missense_variant 0.16 para-aminosalicylic_acid
thyX 3067252 p.Val232Met missense_variant 0.17 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.24 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067490 p.Ala152Glu missense_variant 0.25 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067510 c.436C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.23 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.21 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.2 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.19 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.18 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.21 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.23 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067598 c.348C>T synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.21 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.24 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067691 p.Ile85Leu missense_variant 0.25 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.2 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.19 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.18 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067877 c.69G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074034 c.438T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074100 p.Asp124Asn missense_variant 0.24 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074163 p.Ala103Thr missense_variant 0.22 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.24 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.19 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3449158 p.Ser219Ala missense_variant 1.0 ethionamide Uncertain significance
lpqB 3624701 c.210T>C synonymous_variant 0.24 rifampicin
bedaquiline
lpqB 3624704 c.207G>C synonymous_variant 0.23 rifampicin
bedaquiline
lpqB 3624707 c.204G>C synonymous_variant 0.24 rifampicin
bedaquiline
lpqB 3624722 c.189C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624749 c.162G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624755 c.154_156delTTAinsCTG synonymous_variant 0.19 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625087 p.Ala509Ser missense_variant 0.19 rifampicin
bedaquiline
mtrB 3625093 p.Glu507Asp missense_variant 0.22 rifampicin
bedaquiline
lpqB 3625117 c.-207T>G upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625123 c.-213T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625135 c.1479A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625138 c.-228C>G upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625141 c.-231T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3625149 p.Val489Ile missense_variant 0.23 rifampicin
bedaquiline
lpqB 3625161 c.-251T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625162 c.1452T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625186 c.-276T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625189 c.1425A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625195 c.-285A>G upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625201 c.-291T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625206 p.Ser470Ala missense_variant 0.22 rifampicin
bedaquiline
mtrB 3625222 c.1392T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625225 c.-315G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625518 c.-608T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625525 c.-615G>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625528 c.-618G>T upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625537 c.-627T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625543 c.-633G>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625569 c.1045T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.26 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.29 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.28 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.25 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625711 c.903C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.29 rifampicin
bedaquiline
lpqB 3625749 c.-839C>T upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.31 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.32 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626900 c.-287G>A upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626912 c.-299T>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626927 c.-314G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626945 c.-332C>T upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626957 c.-344G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3627146 c.204C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.19 rifampicin
bedaquiline
fbiA 3640346 c.-196delA upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
rpoA 3877553 p.Glu319Gln missense_variant 0.24 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.24 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.27 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.25 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.25 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.21 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.29 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.27 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.33 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.31 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.31 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.3 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.29 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.28 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.28 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.27 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.32 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.31 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.25 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.23 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.23 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.22 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.23 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.22 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.2 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.2 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.19 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.19 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.2 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.21 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.21 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.2 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.17 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.17 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.17 rifampicin
rpoA 3878199 c.309T>C synonymous_variant 0.17 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.21 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.21 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.19 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.2 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.22 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.22 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.25 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.23 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.23 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.23 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.23 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.23 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.23 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.25 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.25 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.24 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.21 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.2 rifampicin
rpoA 3878463 c.45C>A synonymous_variant 0.17 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.19 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.18 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.17 rifampicin
rpoA 3878749 c.-242G>T upstream_gene_variant 0.17 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.19 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.2 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878806 c.-299C>A upstream_gene_variant 0.21 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.19 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878838 c.-331A>T upstream_gene_variant 0.15 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.16 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878890 c.-383C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878896 c.-389G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.19 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878932 c.-425G>A upstream_gene_variant 0.24 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.24 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.22 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.2 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.2 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.18 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.17 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.17 rifampicin
clpC1 4038356 c.2349T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038407 c.2298G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.19 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.2 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.21 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.23 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.16 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038498 p.Ser736Asn missense_variant 0.16 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.25 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.24 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.19 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038857 c.1848C>T synonymous_variant 0.3 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.3 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.28 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.21 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039336 c.1369C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039337 p.Thr456Gln missense_variant 0.18 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039382 c.1323C>A synonymous_variant 0.22 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039480 c.1225C>A synonymous_variant 0.23 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.3 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.3 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.32 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039805 c.900C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.2 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.19 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.21 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040215 p.Ser164Thr missense_variant 0.16 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.18 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.18 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.28 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.32 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.27 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040492 c.213G>A synonymous_variant 0.16 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.18 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.19 pyrazinamide
panD 4044746 c.-467_-465delGTGinsATC upstream_gene_variant 0.18 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.2 pyrazinamide
panD 4044758 c.-477C>T upstream_gene_variant 0.19 pyrazinamide
panD 4044781 c.-500C>T upstream_gene_variant 0.15 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.17 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.21 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.19 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.19 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.23 pyrazinamide
panD 4044848 c.-567T>A upstream_gene_variant 0.21 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.19 pyrazinamide
panD 4044860 c.-579C>G upstream_gene_variant 0.17 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.17 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.18 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.17 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.15 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4139537 c.219G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139541 p.Ile72Thr missense_variant 0.45 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139545 c.211T>C synonymous_variant 0.48 levofloxacin
moxifloxacin Not assoc w R - Interim
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139552 p.Ala68Ser missense_variant 0.52 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139561 c.195G>A synonymous_variant 0.54 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139581 p.Asn59Asp missense_variant 0.44 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139597 c.159C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139601 p.Arg52Gln missense_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139615 c.141G>A synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
glpK 4139651 p.His35Glu missense_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240699 c.837C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.21 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.2 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.22 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.27 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.28 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.28 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.29 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.29 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.27 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.28 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.28 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.27 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.24 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTTG synonymous_variant 0.23 ethambutol
embC 4240903 c.1041C>G synonymous_variant 0.25 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.26 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.26 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.26 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.27 ethambutol
embC 4240945 c.1083T>G synonymous_variant 0.23 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.19 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.19 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.18 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.22 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.24 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.31 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.29 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.26 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.26 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.28 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.26 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.2 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241218 c.1356G>C synonymous_variant 0.16 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.16 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.17 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.2 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.19 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.18 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.18 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.19 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.22 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>A synonymous_variant 0.23 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.21 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.22 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.22 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.22 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.23 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.23 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.21 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.19 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.19 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.2 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.17 ethambutol
embC 4242075 p.Arg738Gln missense_variant 0.97 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 0.98 ethambutol Not assoc w R
embA 4242748 c.-485A>G upstream_gene_variant 0.17 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.16 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.18 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.21 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.21 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.26 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.27 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.26 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.26 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.27 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.24 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.21 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.21 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.2 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.2 ethambutol
embA 4245248 c.2016G>C synonymous_variant 0.23 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.23 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embA 4245282 p.Ile684Val missense_variant 0.16 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.16 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.17 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.17 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.17 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.17 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.21 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.22 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.26 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.26 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.23 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.21 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.21 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.17 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.16 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.17 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.21 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.21 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.22 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.21 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.21 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.25 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.24 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.24 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.23 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.23 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.23 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.2 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248035 p.Val508Ile missense_variant 0.21 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.2 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.2 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.21 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.21 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.24 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.22 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.23 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.22 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.22 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.21 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.17 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.17 ethambutol
embB 4248208 c.1695C>T synonymous_variant 0.16 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.19 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.27 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.28 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.29 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.2 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.18 ethambutol
embB 4248355 c.1842A>C synonymous_variant 0.19 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.17 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248362 p.Ser617Ala missense_variant 0.18 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.16 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.19 ethambutol
ubiA 4269436 p.Ala133Gly missense_variant 0.17 ethambutol
ubiA 4269448 p.Val129Ala missense_variant 0.17 ethambutol
aftB 4269458 c.-622C>T upstream_gene_variant 0.17 ethambutol
aftB 4269471 c.-635C>G upstream_gene_variant 0.16 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R