TB-Profiler result

Run: SRR12708411
Summary

Run ID: SRR12708411

Sample name:

Date: 2024-04-16T03:23:45.908288

Number of reads: 772046

Percentage reads mapped: 50.44

Median coverage: 21.0

Strain: lineage1.2.2.2

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.2.2 Indo-Oceanic RD239 0.97
lineage1.2.2.2 Indo-Oceanic RD239 0.73
lineage1 Indo-Oceanic RD239 0.95
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Gln497Arg Assoc w R
pyrazinamide pncA c.375_389delCGATGAGGTCGATGT Assoc w R - Interim
c.375_389delCGATGAGGTCGATGT Mutation from literature
streptomycin rrs n.517C>T Assoc w R
fluoroquinolones
moxifloxacin gyrA p.Ala90Val Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ofloxacin
levofloxacin gyrA p.Ala90Val Assoc w R
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7570 p.Ala90Val missense_variant 0.74 levofloxacin Assoc w R
moxifloxacin Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.27 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472362 n.517C>T non_coding_transcript_exon_variant 0.26 streptomycin Assoc w R
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
amikacin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.16 kanamycin Assoc w R
amikacin Assoc w R
capreomycin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2288852 c.375_389delCGATGAGGTCGATGT disruptive_inframe_deletion 1.0 pyrazinamide Assoc w R - Interim
pyrazinamide Mutation from literature
embB 4248003 p.Gln497Arg missense_variant 0.93 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 795 c.795A>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.24 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.24 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.26 isoniazid
dnaA 1003 c.1003C>T synonymous_variant 0.25 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.22 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.22 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.16 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.18 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.19 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.21 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.21 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.2 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.2 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.21 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.19 isoniazid
gyrB 5075 c.-165C>T upstream_gene_variant 0.95 levofloxacin
moxifloxacin
gyrB 6112 p.Met291Ile missense_variant 0.93 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 6655 c.-647T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.22 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 7268 c.-34C>T upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7484 c.183T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8452 p.Ala384Val missense_variant 0.94 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9143 c.1842T>C synonymous_variant 0.96 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9267 p.Asn656Gly missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13699 c.-141A>G upstream_gene_variant 1.0 isoniazid Not assoc w R
fgd1 491013 c.231C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491037 c.255C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
hadA 732396 p.Gly156Ala missense_variant 0.18 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.17 isoniazid
nusG 734116 c.-138T>C upstream_gene_variant 0.96 rifampicin Not assoc w R
nusG 734451 c.198G>C synonymous_variant 0.37 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.48 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.37 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760172 c.366G>C synonymous_variant 0.23 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.23 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760187 c.381G>C synonymous_variant 0.21 rifampicin
rpoB 760199 c.393C>G synonymous_variant 0.18 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760274 p.Glu156Asp missense_variant 0.19 rifampicin Uncertain significance
rpoB 760298 c.492G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.29 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760659 c.853_855delTCAinsAGC synonymous_variant 0.23 rifampicin
rpoB 760670 c.864G>C synonymous_variant 0.29 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.3 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.43 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.48 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760958 c.1152G>C synonymous_variant 0.4 rifampicin
rpoB 760961 c.1155C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.4 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.4 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.5 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.48 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.59 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.38 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761204 c.1398C>G synonymous_variant 0.5 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>C synonymous_variant 0.63 rifampicin
rpoB 761261 c.1455G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.36 rifampicin
rpoB 761285 c.1479G>C synonymous_variant 0.35 rifampicin
rpoB 761288 c.1482G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761414 c.1608A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.25 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.26 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761951 c.2145G>C synonymous_variant 0.35 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.35 rifampicin Uncertain significance
rpoB 762002 c.2196C>G synonymous_variant 0.36 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.42 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762026 c.2220G>C synonymous_variant 0.43 rifampicin
rpoB 762029 c.2223C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.35 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762098 c.2292C>G synonymous_variant 0.34 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.42 rifampicin Uncertain significance
rpoB 762140 c.2334G>C synonymous_variant 0.33 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.37 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.31 rifampicin
rpoB 762230 c.2424G>C synonymous_variant 0.22 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>T synonymous_variant 0.24 rifampicin
rpoB 762246 c.2440C>T synonymous_variant 0.4 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.44 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.26 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.31 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.35 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.33 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.27 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.26 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.24 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.24 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.27 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762858 c.3052_3054delACGinsTC frameshift_variant&missense_variant 0.24 rifampicin
rpoC 762863 c.-507T>G upstream_gene_variant 0.3 rifampicin
rpoB 762881 p.Met1025Ile missense_variant 0.27 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762917 c.-453C>T upstream_gene_variant 0.29 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762926 c.-444C>G upstream_gene_variant 0.25 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.24 rifampicin
rpoC 762956 c.-414G>C upstream_gene_variant 0.21 rifampicin
rpoB 762959 c.3153G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>A upstream_gene_variant 0.28 rifampicin
rpoB 762989 c.3183G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.43 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763052 c.-318G>C upstream_gene_variant 0.37 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.42 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.19 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>C synonymous_variant 0.22 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763423 p.Glu18Asp missense_variant 0.19 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 763433 c.64_66delCAAinsAC frameshift_variant&missense_variant 0.18 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.17 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763507 c.138G>C synonymous_variant 0.29 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763552 c.183C>T synonymous_variant 0.48 rifampicin Not assoc w R
rpoC 763570 c.201G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>G synonymous_variant 0.43 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>T synonymous_variant 0.35 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.42 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.41 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.4 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.45 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.38 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.34 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.21 rifampicin
rpoC 763786 c.417C>G synonymous_variant 0.22 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763884 p.Ala172Val missense_variant 0.84 rifampicin Not assoc w R
rpoC 763886 c.517_519delCGGinsAC frameshift_variant&missense_variant 0.84 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.21 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.21 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.22 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.24 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764128 c.759C>G synonymous_variant 0.31 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764149 c.780G>C synonymous_variant 0.36 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.34 rifampicin
rpoC 764164 p.Ile265Met missense_variant 0.33 rifampicin
rpoC 764169 p.Asn267Thr missense_variant 0.31 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.35 rifampicin
rpoC 764215 c.846A>C synonymous_variant 0.28 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.27 rifampicin
rpoC 764239 c.870T>C synonymous_variant 0.25 rifampicin
rpoC 764254 c.885G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.31 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.2 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.29 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.3 rifampicin
rpoC 764275 c.909_911delACA disruptive_inframe_deletion 0.21 rifampicin
rpoC 764284 c.915delGinsCACC conservative_inframe_insertion&synonymous_variant 0.19 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.32 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>T synonymous_variant 0.23 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.26 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.27 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764458 c.1089G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.24 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.26 rifampicin
rpoC 764509 c.1140G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.37 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.49 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.54 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 0.47 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.38 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764707 c.1338G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.35 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.36 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.29 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.26 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.23 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489_1491delTTGinsCC frameshift_variant&missense_variant 0.41 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.48 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579_1581delTTGinsCC frameshift_variant&missense_variant 0.45 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.27 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.27 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766345 c.2976T>C synonymous_variant 0.32 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.38 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.35 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.35 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.22 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.22 rifampicin
rpoC 767035 c.3666G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.45 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.41 rifampicin
rpoC 767093 c.3724_3726delAGCinsTCG synonymous_variant 0.39 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767106 p.Asn1246Ile missense_variant 0.36 rifampicin
rpoC 767113 c.3744G>C synonymous_variant 0.36 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767152 c.3783T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767173 c.3804C>G synonymous_variant 0.28 rifampicin
rpoC 767180 p.Ala1271Thr missense_variant 0.26 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781760 c.201T>C synonymous_variant 0.23 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.31 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.33 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.2 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.53 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.35 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.37 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.43 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.5 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.5 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.58 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.33 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.5 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.49 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.49 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.48 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.44 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.21 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.2 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.28 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
rplC 800618 c.-191T>C upstream_gene_variant 0.23 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.23 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.24 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471997 n.152T>C non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472027 n.182C>T non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472057 n.212C>A non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472062 n.217G>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472068 n.223T>C non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472069 n.224G>A non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472449 n.604C>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472463 n.618G>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472467 n.622G>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472495 n.650C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>T non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>A non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472582 n.737G>A non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472720 n.875C>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473417 n.-241C>T upstream_gene_variant 0.19 capreomycin
linezolid
rrl 1473419 n.-239T>C upstream_gene_variant 0.19 capreomycin
linezolid
rrl 1473420 n.-238A>G upstream_gene_variant 0.19 capreomycin
linezolid
rrl 1473421 n.-237G>A upstream_gene_variant 0.19 capreomycin
linezolid
rrl 1473668 n.11C>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473673 n.16G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473677 n.20C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473679 n.22T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473928 n.271T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474153 n.496C>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474166 n.509G>A non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474450 n.793T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474634 n.977T>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052dupG non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1474711 n.1054_1055insAA non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474715 n.1061delA non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474740 n.1083G>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474747 n.1090C>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.22 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.2 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475065 n.1408G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475067 n.1410A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475201 n.1544G>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475422 n.1765A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475481 n.1824C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475752 n.2095C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475758 n.2101_2108delACCCGCAAinsGCCACTTCG non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.69 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476087 n.2430C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476091 n.2434_2435insC non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.66 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.66 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.55 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.64 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.76 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867delCinsGA non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.74 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.72 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833589 c.48A>C synonymous_variant 0.21 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.19 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833607 c.66T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.18 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.19 pyrazinamide
rpsA 1833623 p.Lys28Ala missense_variant 0.19 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.38 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.43 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.43 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.45 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.45 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.42 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.39 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.41 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833838 c.297G>A synonymous_variant 0.29 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833850 c.309C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.36 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.34 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.38 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.48 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.52 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.33 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834108 c.567C>A synonymous_variant 0.19 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834135 c.594G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.24 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.28 pyrazinamide Uncertain significance
rpsA 1834465 c.924T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834468 c.927A>C synonymous_variant 0.28 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834534 c.993C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
rpsA 1834543 c.1002C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834556 p.Ala339Thr missense_variant 0.36 pyrazinamide Uncertain significance
rpsA 1834573 c.1032G>A synonymous_variant 0.34 pyrazinamide
rpsA 1834574 p.Met345Leu missense_variant 0.34 pyrazinamide
rpsA 1834600 c.1059G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834612 c.1071G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.25 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.26 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834759 c.1218A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834761 p.Phe407Tyr missense_variant 0.22 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.32 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.21 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834788 p.Ala416Gly missense_variant 0.22 pyrazinamide
rpsA 1834810 c.1269C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834813 c.1272G>T synonymous_variant 0.26 pyrazinamide
rpsA 1834831 c.1290G>T synonymous_variant 0.24 pyrazinamide
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
ndh 2102240 p.Arg268His missense_variant 1.0 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 0.89 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168742 p.Gly624Asp missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222098 p.Thr356Lys missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223553 c.-389C>A upstream_gene_variant 0.91 clofazimine Not assoc w R
bedaquiline Uncertain significance
kasA 2517950 c.-165C>G upstream_gene_variant 0.23 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 0.95 isoniazid
Rv2477c 2783656 c.387G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyX 3068062 c.-117A>C upstream_gene_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625579 c.-669A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.25 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.33 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3626467 c.147G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3626732 c.-119A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626822 p.Asp176Glu missense_variant 0.16 bedaquiline
rifampicin
mtrB 3626825 c.-212T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626831 c.-218T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626840 c.-227C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627104 c.-491C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.23 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877734 c.774G>C synonymous_variant 0.17 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.21 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878217 c.289_291delCTAinsGG frameshift_variant&missense_variant 0.32 rifampicin
rpoA 3878244 p.Glu88Asp missense_variant 0.23 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.35 rifampicin
rpoA 3878251 c.256_257delTCinsAG synonymous_variant 0.21 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.23 rifampicin
rpoA 3878259 c.249G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878262 c.244_246delAGCinsGA frameshift_variant&missense_variant 0.23 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.24 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878367 c.141C>G synonymous_variant 0.26 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.26 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.32 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.32 rifampicin
rpoA 3879181 c.-676_-674delAAGinsCGT upstream_gene_variant 0.35 rifampicin
rpoA 3879202 c.-695T>A upstream_gene_variant 0.3 rifampicin
clpC1 4038755 c.1950G>T synonymous_variant 0.53 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.61 pyrazinamide
clpC1 4038791 c.1914G>C synonymous_variant 0.65 pyrazinamide
clpC1 4038794 p.Ser637Thr missense_variant 0.65 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.78 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.78 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4039031 c.1674T>A synonymous_variant 0.52 pyrazinamide
clpC1 4039040 c.1665C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039043 c.1662G>T synonymous_variant 0.5 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.5 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.63 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.45 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.32 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039295 c.1410A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.21 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.27 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039499 c.1206G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.31 pyrazinamide Uncertain significance
clpC1 4039577 c.1128T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.29 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.44 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.47 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.49 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039925 c.780C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.24 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040063 c.642G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040429 c.274_276delTTGinsCC frameshift_variant&missense_variant 0.28 pyrazinamide
clpC1 4040435 c.270G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040462 c.243C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.47 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040517 p.Val63Ala missense_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040537 c.168G>C synonymous_variant 0.39 pyrazinamide
clpC1 4040719 c.-15A>G upstream_gene_variant 0.89 pyrazinamide Uncertain significance
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4241042 p.Asn394Asp missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245670 p.Ala813Gly missense_variant 0.96 ethambutol Not assoc w R - Interim
embA 4245969 p.Pro913Ser missense_variant 0.94 ethambutol Not assoc w R
embB 4246979 p.Gly156Cys missense_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
aftB 4267960 p.Val293Met missense_variant 1.0 ethambutol Uncertain significance
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326148 c.1326G>T synonymous_variant 0.9 ethionamide Not assoc w R - Interim
ethA 4326439 p.Asn345Lys missense_variant 0.95 ethionamide Uncertain significance
whiB6 4338203 p.Arg107Cys missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 0.97 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407848 p.Ala119Thr missense_variant 0.95 streptomycin Uncertain significance
gid 4407873 c.330G>T synonymous_variant 0.95 streptomycin Not assoc w R