TB-Profiler result

Run: ERR3799304
Summary

Run ID: ERR3799304

Sample name:

Date: 2024-10-05T08:31:54.022099

Number of reads: 3164986

Percentage reads mapped: 69.88

Median coverage: 151.0

Strain: lineage6.1.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage6.1.1 West-Africa 2 RD702 0.99
lineage6 West-Africa 2 RD702 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Ala356Val Uncertain significance Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embB 4247580 p.Ala356Val missense_variant 0.26 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6446 p.Ala403Ser missense_variant 0.96 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7480 p.Phe60Tyr missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7502 c.201C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7526 c.225G>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7643 c.342C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8360 c.1059G>A synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8372 c.1071G>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8392 p.Tyr364Phe missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8402 p.Asp367Glu missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8408 c.1107A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8429 c.1128C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8447 c.1146C>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8450 c.1149G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8492 c.1191G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8493 p.Leu398Phe missense_variant 0.78 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8504 c.1203G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8531 c.1230G>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8535 p.Glu412Gln missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8555 c.1254G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8585 c.1284C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8694 c.1393C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8711 c.1410A>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8720 c.1419G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8765 p.Asp488Glu missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8789 c.1488C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8792 c.1491G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8798 c.1497C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8810 c.1509A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8813 p.Asp504Glu missense_variant 0.3 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8818 p.Ser506Asn missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8829 c.1528T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8840 c.1539C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8888 c.1587C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8933 c.1632G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8936 c.1635G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8983 p.Cys561Ser missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9003 c.1702C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9038 c.1737C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9095 c.1794C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9101 c.1800A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9104 c.1803C>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9110 c.1809G>A synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9128 c.1827C>A synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9147 p.Gly616Ser missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9161 c.1860C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9167 c.1866C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9183 p.Arg628Lys missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9266 c.1965C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9287 c.1986G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9315 c.2014C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9326 c.2025G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
fgd1 490971 c.189A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 490974 c.192T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 490980 p.Asn66Lys missense_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 490983 c.201G>A synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 490988 p.Leu69Gln missense_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 490995 c.213C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 490998 c.216T>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491007 c.225G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491013 c.231C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491016 c.234C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491094 c.312C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491110 p.Ala110Ser missense_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491115 c.333G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491136 c.354C>T synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491144 p.Ala121Glu missense_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491168 p.Phe129Tyr missense_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491668 p.Lys296Glu missense_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575713 c.366G>A synonymous_variant 0.2 isoniazid
ethionamide
ccsA 619507 c.-384A>G upstream_gene_variant 0.23 kanamycin
capreomycin
amikacin
Rv0565c 656432 p.Gly347Ser missense_variant 0.95 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
rpoB 760196 c.390C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.27 rifampicin
rpoB 760295 c.489C>T synonymous_variant 0.27 rifampicin
rpoB 760307 c.501T>C synonymous_variant 0.26 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.26 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.26 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.27 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.27 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760358 c.552C>G synonymous_variant 0.28 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.28 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.27 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.26 rifampicin
rpoB 760403 c.597C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760412 c.606C>T synonymous_variant 0.25 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760472 c.666C>T synonymous_variant 0.25 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.24 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760493 c.687C>G synonymous_variant 0.26 rifampicin
rpoB 760520 c.714C>G synonymous_variant 0.27 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.27 rifampicin Uncertain significance
rpoB 760526 c.720G>A synonymous_variant 0.27 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.26 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.27 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.27 rifampicin
rpoB 760601 c.795C>T synonymous_variant 0.25 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760622 c.816C>T synonymous_variant 0.24 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.25 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.24 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.29 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.3 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.3 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.31 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.32 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.31 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.3 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.29 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.31 rifampicin
rpoB 760855 p.Thr350Met missense_variant 0.69 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.3 rifampicin
rpoB 760916 c.1110C>G synonymous_variant 0.27 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.27 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.26 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.26 rifampicin
rpoB 760937 c.1131G>A synonymous_variant 0.27 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760969 p.Ser388Leu missense_variant 0.75 rifampicin Not assoc w R
rpoB 760973 c.1167G>C synonymous_variant 0.25 rifampicin
rpoB 760982 c.1176G>T synonymous_variant 0.24 rifampicin
rpoB 760985 c.1179G>T synonymous_variant 0.25 rifampicin
rpoB 760991 c.1185G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>T synonymous_variant 0.26 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.26 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.28 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.28 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.29 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.26 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.27 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.24 rifampicin
rpoB 761192 c.1386C>G synonymous_variant 0.23 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761240 c.1434C>T synonymous_variant 0.2 rifampicin
rpoB 761345 c.1539G>T synonymous_variant 0.21 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.21 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.22 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.22 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.23 rifampicin
rpoB 761432 c.1626C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761435 c.1629T>C synonymous_variant 0.23 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.23 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.23 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.22 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.22 rifampicin
rpoB 761465 c.1659G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761471 c.1665C>T synonymous_variant 0.22 rifampicin
rpoB 761477 c.1671C>T synonymous_variant 0.23 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.23 rifampicin
rpoB 761504 c.1698C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.24 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.23 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.24 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>A synonymous_variant 0.21 rifampicin
rpoB 761648 c.1842T>C synonymous_variant 0.22 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.25 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.24 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 1.0 rifampicin Not assoc w R
rpoB 761750 c.1944G>C synonymous_variant 0.21 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.2 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.21 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.2 rifampicin
rpoB 761828 c.2022C>T synonymous_variant 0.19 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.21 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.23 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.2 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.21 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.23 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.28 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.26 rifampicin
rpoB 762038 c.2232C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.35 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.35 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.36 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>T synonymous_variant 0.33 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.33 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.32 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.32 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.3 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.3 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.3 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.3 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.3 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.3 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.27 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.25 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.25 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762431 c.2625C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762441 c.2635C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762449 c.2643C>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.23 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.23 rifampicin Uncertain significance
rpoC 762902 c.-468C>T upstream_gene_variant 0.3 rifampicin
rpoC 762917 c.-453C>T upstream_gene_variant 0.27 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>G upstream_gene_variant 0.29 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.27 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.24 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.22 rifampicin
rpoC 763205 c.-165G>T upstream_gene_variant 0.2 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.2 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.19 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.23 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.25 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.34 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.36 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.31 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.31 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763726 c.357C>T synonymous_variant 0.37 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.39 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.39 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.39 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763771 c.402C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763780 c.411C>G synonymous_variant 0.4 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.39 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763836 p.Ala156Val missense_variant 0.31 rifampicin
rpoC 763851 p.Ala161Gly missense_variant 0.28 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.28 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.27 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.29 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.3 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.29 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.29 rifampicin
rpoC 763891 c.522G>T synonymous_variant 0.29 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.3 rifampicin
rpoC 763919 c.550C>T synonymous_variant 0.33 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.31 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.32 rifampicin
rpoC 763951 c.582G>A synonymous_variant 0.34 rifampicin
rpoC 763963 c.594C>G synonymous_variant 0.34 rifampicin
rpoC 763967 p.Gly200Ser missense_variant 0.32 rifampicin
rpoC 763972 c.603C>T synonymous_variant 0.33 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.32 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.32 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.32 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.35 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.33 rifampicin
rpoC 764044 c.675T>G synonymous_variant 0.34 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.35 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.38 rifampicin
rpoC 764101 c.732C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764159 c.790C>T synonymous_variant 0.31 rifampicin
rpoC 764167 c.798G>A synonymous_variant 0.31 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.29 rifampicin
rpoC 764215 c.846A>C synonymous_variant 0.27 rifampicin
rpoC 764218 c.849C>T synonymous_variant 0.27 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>A synonymous_variant 0.24 rifampicin
rpoC 764246 c.877_879delCTCinsTTG synonymous_variant 0.24 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.25 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.25 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764320 c.951C>G synonymous_variant 0.2 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.21 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.21 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.22 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.32 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.32 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.35 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.3 rifampicin
rpoC 764605 c.1236G>A synonymous_variant 0.27 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764686 c.1317C>T synonymous_variant 0.23 rifampicin
rpoC 764696 c.1327C>T synonymous_variant 0.23 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.21 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764782 c.1413C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.21 rifampicin
rpoC 764803 c.1434C>G synonymous_variant 0.21 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.2 rifampicin Not assoc w R
rpoC 765370 c.2001G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.22 rifampicin Uncertain significance
rpoC 765391 c.2022C>T synonymous_variant 0.24 rifampicin
rpoC 765406 c.2037G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765409 c.2040T>C synonymous_variant 0.24 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.25 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Ser missense_variant 0.31 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.32 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.31 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765517 c.2148C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.36 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.34 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.33 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.33 rifampicin
rpoC 765571 c.2202C>T synonymous_variant 0.33 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.34 rifampicin
rpoC 765622 p.Glu751Asp missense_variant 0.33 rifampicin
rpoC 765625 c.2256C>T synonymous_variant 0.32 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765728 p.Gln787Lys missense_variant 0.3 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765752 p.Asp795Ser missense_variant 0.3 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.3 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.3 rifampicin
rpoC 765790 c.2421C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765793 c.2424C>G synonymous_variant 0.29 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.29 rifampicin
rpoC 765814 c.2445A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.31 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.3 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.25 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.23 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.2 rifampicin
rpoC 766231 c.2862T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.21 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.22 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.22 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.23 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.24 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.24 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.25 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.28 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.3 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.29 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.29 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.3 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.3 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.31 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.31 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.3 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.3 rifampicin
rpoC 766660 c.3291G>A synonymous_variant 0.31 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.3 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.31 rifampicin
rpoC 766700 c.3331C>T synonymous_variant 0.34 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.33 rifampicin
rpoC 766733 c.3364C>T synonymous_variant 0.32 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.31 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.32 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.29 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.31 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766801 c.3432C>G synonymous_variant 0.28 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.29 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766883 p.Ser1172Ala missense_variant 0.32 rifampicin Uncertain significance
rpoC 766894 c.3525T>C synonymous_variant 0.32 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.31 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.3 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.31 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.28 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>G synonymous_variant 0.3 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.3 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.29 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.3 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.34 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.28 rifampicin
rpoC 767158 c.3789T>A synonymous_variant 0.25 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.22 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781832 c.273T>G synonymous_variant 0.22 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.21 streptomycin Not assoc w R - Interim
rpsL 781859 c.300T>G synonymous_variant 0.23 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.22 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.22 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.22 streptomycin
rpsL 781883 c.324G>A synonymous_variant 0.24 streptomycin
rpsL 781886 c.327C>T synonymous_variant 0.24 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.24 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.26 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.24 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.24 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.25 streptomycin
rplC 800232 c.-577G>T upstream_gene_variant 0.98 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.19 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.2 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.19 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.19 linezolid
rplC 801255 c.447C>A synonymous_variant 0.2 linezolid
rplC 801285 c.477G>A synonymous_variant 0.21 linezolid
rplC 801330 c.522G>T synonymous_variant 0.19 linezolid
rplC 801333 c.525G>C synonymous_variant 0.19 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
fbiC 1303629 c.699C>T synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303662 c.732C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303674 c.744C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303686 c.756C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.19 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304574 c.1644C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304610 c.1680C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304625 c.1695C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304797 p.Ala623Thr missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304823 c.1893C>T synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>G synonymous_variant 0.25 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.23 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304868 c.1938G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304872 c.1942_1943delAGinsTC synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304915 p.Asp662Gly missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304934 c.2004C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304946 c.2016G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304955 c.2025G>A synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
sigE 1364790 c.378T>C synonymous_variant 0.22 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.22 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.22 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.22 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.22 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.23 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.24 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.24 pyrazinamide
sigE 1364868 c.456T>C synonymous_variant 0.22 pyrazinamide
sigE 1364871 c.459C>G synonymous_variant 0.21 pyrazinamide
sigE 1364883 c.471G>A synonymous_variant 0.23 pyrazinamide
sigE 1364889 c.477A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
sigE 1364892 c.480C>G synonymous_variant 0.22 pyrazinamide
sigE 1364913 c.501C>G synonymous_variant 0.21 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.21 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.21 pyrazinamide
sigE 1364928 c.516C>T synonymous_variant 0.2 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.18 pyrazinamide
Rv1258c 1406685 p.Val219Ala missense_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
embR 1416633 p.Leu239Val missense_variant 1.0 ethambutol Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
atpE 1461251 c.207G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472463 n.618G>C non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473797 n.140G>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473831 n.174G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473918 n.261C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473994 n.337C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474011 n.354G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474018 n.361G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474030 n.373G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474089 n.432C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474100 n.443C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474110 n.453A>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474945 n.1288C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474952 n.1296_1300delCATCC non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474962 n.1305T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474967 n.1311_1315delGGGTG non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474995 n.1338T>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475005 n.1348C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475006 n.1349A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475007 n.1350C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475018 n.1361G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475027 n.1370G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475028 n.1371G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475401 n.1745delC non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475404 n.1747A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475405 n.1748A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475453 n.1796T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475487 n.1830C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid Uncertain significance
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475605 n.1948A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475617 n.1960C>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475625 n.1968G>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475637 n.1980T>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2103C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475999 n.2342G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476047 n.2390G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476077 n.2420T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674434 p.Val78Ala missense_variant 0.96 isoniazid Not assoc w R
ethionamide Uncertain significance
inhA 1674729 c.528G>A synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674745 p.Tyr182Asp missense_variant 0.2 isoniazid
ethionamide
inhA 1674756 c.555T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674765 c.564C>T synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674774 c.573A>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674777 c.576C>A synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674792 c.591G>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674820 c.619_621delCTCinsTTG synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674828 c.627G>A synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.24 isoniazid
ethionamide
inhA 1674870 c.669T>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674876 c.675C>G synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674879 c.678T>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674888 c.687C>T synonymous_variant 0.23 isoniazid
ethionamide
rpsA 1833589 c.48A>T synonymous_variant 0.21 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833613 c.72C>A synonymous_variant 0.23 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.23 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1833790 c.249T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.25 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.25 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.28 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.3 pyrazinamide
rpsA 1833895 c.354G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833970 c.429G>A synonymous_variant 0.24 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.25 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.3 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.26 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.28 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.31 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.31 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.29 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.31 pyrazinamide
rpsA 1834603 c.1062G>A synonymous_variant 0.29 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834633 c.1092A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834699 p.Glu386Asp missense_variant 0.2 pyrazinamide
tsnR 1853370 c.-236G>T upstream_gene_variant 0.2 linezolid
tsnR 1853375 c.-231G>A upstream_gene_variant 0.2 linezolid
tsnR 1853393 c.-213C>T upstream_gene_variant 0.2 linezolid
tsnR 1853395 c.-211T>C upstream_gene_variant 0.2 linezolid
tsnR 1854026 p.Gly141Arg missense_variant 0.99 linezolid Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 0.99 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
bacA 2063121 c.1608A>T synonymous_variant 1.0 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
katG 2154286 p.Met609Thr missense_variant 1.0 isoniazid Uncertain significance
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517962 c.-153C>G upstream_gene_variant 0.21 isoniazid
kasA 2517965 c.-150C>T upstream_gene_variant 0.19 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.99 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.26 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.26 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.27 isoniazid
kasA 2518573 c.459G>C synonymous_variant 0.27 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.27 isoniazid
kasA 2518582 c.468G>C synonymous_variant 0.28 isoniazid
kasA 2518583 p.Gln157Glu missense_variant 0.28 isoniazid
kasA 2518594 c.480C>T synonymous_variant 0.32 isoniazid
kasA 2518597 c.483C>G synonymous_variant 0.33 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.36 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.36 isoniazid
kasA 2518636 c.522C>A synonymous_variant 0.4 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.39 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.4 isoniazid
kasA 2518645 c.531G>C synonymous_variant 0.41 isoniazid
kasA 2518651 c.537C>G synonymous_variant 0.41 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.43 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.44 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.43 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.42 isoniazid
kasA 2518681 c.567C>T synonymous_variant 0.39 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.38 isoniazid
kasA 2518687 p.Asp191Glu missense_variant 0.36 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.37 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.37 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.36 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.35 isoniazid
kasA 2518717 c.603C>G synonymous_variant 0.35 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.35 isoniazid
kasA 2518735 c.621C>T synonymous_variant 0.34 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.32 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.3 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.29 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.27 isoniazid
kasA 2518795 c.681C>A synonymous_variant 0.24 isoniazid
kasA 2518798 c.684G>C synonymous_variant 0.24 isoniazid
Rv2477c 2783419 c.624G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783427 p.Pro206Ala missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin
Rv2477c 2783431 c.612C>T synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783437 c.606G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783632 c.411C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783743 c.300C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783788 c.255T>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783806 c.237G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783827 c.216C>T synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783836 c.207C>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>T synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2752c 3066384 c.-193G>A upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066387 c.-196G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066399 c.-210_-208delATTinsGTC upstream_gene_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066402 c.-211C>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066420 c.-229C>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066423 c.-232C>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066426 c.-235T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066429 c.-238G>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066432 c.-241T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066437 c.-246G>A upstream_gene_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066459 c.-268T>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066465 c.-276_-274delGGGinsAGC upstream_gene_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066471 c.-280A>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066474 c.-283G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066477 c.-286C>T upstream_gene_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066480 c.-291_-289delGCCinsTCT upstream_gene_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066483 c.-292T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066513 c.-322C>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066527 c.-336C>T upstream_gene_variant 0.34 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066543 c.-352C>A upstream_gene_variant 0.34 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066560 c.-369C>T upstream_gene_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066567 c.-376C>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066583 c.-392C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066597 c.-406C>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066617 c.-426G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyA 3073854 c.618C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073889 p.Ser195Ala missense_variant 0.2 para-aminosalicylic_acid
thyA 3073905 c.567C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.22 para-aminosalicylic_acid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 0.99 cycloserine
Rv3236c 3612143 p.Arg325His missense_variant 1.0 pyrazinamide Uncertain significance
lpqB 3624350 c.561G>T synonymous_variant 0.88 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
lpqB 3624486 p.Asp142Gly missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625138 c.-228C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625147 c.-237C>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625162 c.1452T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625183 c.-273G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625186 c.-276T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625189 c.1425A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625195 c.-285A>G upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625198 c.-288C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625201 c.-291T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625207 c.-297C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625213 c.-303C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625222 c.1392T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625234 c.-324G>A upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625240 c.-330T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625243 c.-333T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625251 c.-341C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625255 c.-345T>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625267 c.1347T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625663 c.-753G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625690 c.-780T>G upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625699 c.915C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625717 c.-807C>T upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3625747 c.867G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.24 rifampicin Uncertain significance
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625783 c.-873C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626885 c.-272A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626924 c.-311G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626927 c.-314G>A upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626933 c.-320C>T upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626954 c.-341C>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626996 c.-383G>A upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627023 c.-410C>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627059 c.-446G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627101 c.-488C>G upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627110 c.-497G>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627137 c.-526_-524delTTGinsCTA upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627143 c.-530G>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3627187 c.163T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627197 c.-584T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627203 c.-590C>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627212 c.-599C>T upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627218 c.-605G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627233 c.-620T>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3627239 c.111C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.22 rifampicin
bedaquiline
rpoA 3877557 c.951C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>C synonymous_variant 0.27 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.29 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.28 rifampicin
rpoA 3877638 c.870T>G synonymous_variant 0.3 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877677 p.Ala277Ser missense_variant 0.31 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877685 c.823C>T synonymous_variant 0.31 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.38 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877758 c.750G>C synonymous_variant 0.39 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877815 c.693C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877830 c.678C>T synonymous_variant 0.36 rifampicin
rpoA 3877839 c.669G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877851 c.657C>T synonymous_variant 0.36 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.37 rifampicin
rpoA 3877865 c.643C>T synonymous_variant 0.37 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.37 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>C synonymous_variant 0.42 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.4 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.4 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877968 c.540C>G synonymous_variant 0.41 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.35 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.35 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.35 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.35 rifampicin
rpoA 3878043 c.465G>C synonymous_variant 0.36 rifampicin
rpoA 3878046 c.462T>G synonymous_variant 0.35 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.34 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.33 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.33 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.33 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.34 rifampicin
rpoA 3878097 c.411G>A synonymous_variant 0.35 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.35 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.33 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.34 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.34 rifampicin
rpoA 3878145 c.363C>G synonymous_variant 0.31 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.28 rifampicin
rpoA 3878166 c.342C>G synonymous_variant 0.3 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.31 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878229 c.279C>G synonymous_variant 0.3 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.33 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.36 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.37 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.35 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.36 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.37 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>C synonymous_variant 0.34 rifampicin
rpoA 3878334 c.174T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.37 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.38 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.37 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.4 rifampicin
rpoA 3878384 c.124C>T synonymous_variant 0.39 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.38 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.38 rifampicin
rpoA 3878418 c.90C>T synonymous_variant 0.36 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.38 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.36 rifampicin
rpoA 3878458 p.Asn17Ser missense_variant 0.35 rifampicin
rpoA 3878471 p.Val13Leu missense_variant 0.35 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.35 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.26 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.29 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.33 rifampicin
rpoA 3878713 c.-206G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.23 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.29 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878761 c.-254G>A upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878764 c.-257A>G upstream_gene_variant 0.3 rifampicin
rpoA 3878776 c.-269G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878779 c.-274_-272delATCinsGTT upstream_gene_variant 0.28 rifampicin
rpoA 3878788 c.-281G>T upstream_gene_variant 0.27 rifampicin
rpoA 3878803 c.-296G>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.28 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.29 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.31 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.32 rifampicin
rpoA 3878836 c.-329G>C upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878842 c.-335G>C upstream_gene_variant 0.32 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.33 rifampicin
rpoA 3878869 c.-362G>C upstream_gene_variant 0.33 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878881 c.-374C>G upstream_gene_variant 0.32 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.33 rifampicin
rpoA 3878894 c.-387A>G upstream_gene_variant 0.34 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.34 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878923 c.-417_-416delGCinsCG upstream_gene_variant 0.35 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.39 rifampicin Uncertain significance
rpoA 3878953 c.-446C>G upstream_gene_variant 0.38 rifampicin
rpoA 3878962 c.-455G>A upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGTG upstream_gene_variant 0.3 rifampicin
rpoA 3878995 c.-488A>G upstream_gene_variant 0.28 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3879001 c.-494C>T upstream_gene_variant 0.25 rifampicin
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.24 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.27 rifampicin
rpoA 3879037 c.-530G>A upstream_gene_variant 0.29 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.3 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.24 rifampicin
clpC1 4038596 c.2109A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038773 c.1932T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.31 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4038809 c.1896G>A synonymous_variant 0.33 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038875 c.1830C>G synonymous_variant 0.38 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038893 c.1812C>T synonymous_variant 0.39 pyrazinamide
clpC1 4038902 c.1803C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.37 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.38 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.39 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039025 c.1680C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.32 pyrazinamide
clpC1 4039112 c.1593C>A synonymous_variant 0.32 pyrazinamide
clpC1 4039119 c.1585_1586delTCinsAG synonymous_variant 0.3 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.31 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039193 c.1512C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039223 c.1482C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039238 c.1467C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039243 c.1462C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039259 c.1446G>A synonymous_variant 0.27 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.27 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039319 p.Ala462Thr missense_variant 0.26 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.26 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.25 pyrazinamide
clpC1 4039361 c.1344C>A synonymous_variant 0.24 pyrazinamide
clpC1 4039382 c.1323C>T synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039391 c.1314T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039412 c.1293T>A synonymous_variant 0.24 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.28 pyrazinamide
clpC1 4039508 c.1197G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039526 c.1179G>A synonymous_variant 0.31 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039553 c.1152C>A synonymous_variant 0.32 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.33 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039583 c.1122C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039664 c.1041G>T synonymous_variant 0.33 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039748 c.957G>A synonymous_variant 0.28 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.27 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039805 c.900C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.27 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039964 c.741C>T synonymous_variant 0.2 pyrazinamide
clpC1 4040000 c.705C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040015 c.690G>A synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040021 c.684A>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040090 p.Ser205Thr missense_variant 0.2 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040195 c.510G>T synonymous_variant 0.32 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.32 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.32 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.34 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.34 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.35 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.36 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.38 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.39 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040309 c.396C>T synonymous_variant 0.44 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.43 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.39 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.41 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.39 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.38 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.35 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.36 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040419 c.286C>T synonymous_variant 0.29 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040462 c.243C>T synonymous_variant 0.29 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040495 c.210C>A synonymous_variant 0.34 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040525 c.180C>T synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.33 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.31 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040588 c.117T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040591 c.114C>T synonymous_variant 0.29 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.29 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCTG synonymous_variant 0.28 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.28 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.29 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4138568 c.1188A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138574 c.1182G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138583 c.1173G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138631 c.1125C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138646 c.1110G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138670 c.1086G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138681 p.Met359Val missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138682 c.1074C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138702 p.Gln352Glu missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138703 c.1053C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138706 c.1050C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138714 p.Ala348Ser missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138715 c.1041G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138751 c.1005T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139183 c.572dupG frameshift_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 0.99 ethambutol Not assoc w R
embC 4241452 c.1590G>C synonymous_variant 0.2 ethambutol
embC 4241455 c.1593C>T synonymous_variant 0.2 ethambutol
embC 4241461 c.1599C>G synonymous_variant 0.19 ethambutol
embC 4241623 c.1761C>G synonymous_variant 0.17 ethambutol
embC 4241843 p.Leu661Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243570 p.Thr113Arg missense_variant 1.0 ethambutol Uncertain significance
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244379 p.Pro383Ser missense_variant 1.0 ethambutol Not assoc w R
embA 4245078 p.Trp616Gly missense_variant 0.21 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.21 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.22 ethambutol
embA 4245093 p.Ile621Val missense_variant 0.22 ethambutol Uncertain significance
embA 4245125 c.1893G>C synonymous_variant 0.23 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.23 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.24 ethambutol
embA 4245183 c.1951C>T synonymous_variant 0.21 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.21 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.21 ethambutol
embA 4245223 p.Tyr664Phe missense_variant 0.2 ethambutol
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247470 c.957T>C synonymous_variant 0.22 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.22 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.21 ethambutol
embB 4247506 c.993C>G synonymous_variant 0.21 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.22 ethambutol
embB 4247527 c.1014G>C synonymous_variant 0.23 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.25 ethambutol
embB 4247550 p.Ala346Asp missense_variant 0.26 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.27 ethambutol
embB 4247566 c.1053C>G synonymous_variant 0.28 ethambutol
embB 4247572 c.1059A>C synonymous_variant 0.27 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.25 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.22 ethambutol
embB 4247638 c.1125G>C synonymous_variant 0.21 ethambutol
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248070 c.1557T>C synonymous_variant 0.2 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.24 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.27 ethambutol
embB 4248118 c.1605T>G synonymous_variant 0.27 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.26 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.26 ethambutol
embB 4248133 c.1620C>A synonymous_variant 0.26 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.27 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.26 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.26 ethambutol
embB 4248146 p.Ile545Leu missense_variant 0.26 ethambutol
embB 4248149 p.Thr546Ser missense_variant 0.26 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4248161 c.1648C>T synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4248169 c.1656C>A synonymous_variant 0.29 ethambutol
embB 4248190 c.1677G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4248200 p.Ile563Val missense_variant 0.25 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.25 ethambutol Uncertain significance
embB 4248211 c.1698G>A synonymous_variant 0.25 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.25 ethambutol
embB 4248241 c.1728C>T synonymous_variant 0.25 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.21 ethambutol
embB 4248631 c.2118G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
ubiA 4269351 c.483C>T synonymous_variant 0.92 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269522 c.312C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326465 p.Ile337Val missense_variant 0.99 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4408034 p.Glu57Lys missense_variant 1.0 streptomycin Uncertain significance