TB-Profiler result

Run: SRR25827497
Summary

Run ID: SRR25827497

Sample name:

Date: 2024-05-20T10:04:09.632680

Number of reads: 2237712

Percentage reads mapped: 61.75

Median coverage: 63.0

Strain: lineage2.2.1;lineage3

Spoligotype:

Drug-resistance: XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.51
lineage2 East-Asian RD105 0.5
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.51
lineage2.2 East-Asian (Beijing) RD105;RD207 0.48
La1.7.1 M.bovis None 0.05
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
p.His312Arg Mutation from literature
p.Tyr384Asn Mutation from literature
p.Ala388Gly Mutation from literature
p.Asn399Asp Mutation from literature
pyrazinamide pncA p.Thr177Pro Assoc w R
p.His71Arg Assoc w R
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
gid c.87delC Assoc w R
fluoroquinolones
moxifloxacin gyrA p.Asp94Gly Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Asp94Gly Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide ethA c.774dupG Assoc w R
clofazimine mmpR5 c.141_142dupTC Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
para-aminosalicylic_acid thyX c.-16C>T Mutation from literature
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline mmpR5 c.141_142dupTC Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7582 p.Asp94Gly missense_variant 1.0 moxifloxacin Assoc w R High-level resistance
levofloxacin Assoc w R
rpoB 761155 p.Ser450Leu missense_variant 0.37 rifampicin Assoc w R
mmpR5 779129 c.141_142dupTC frameshift_variant 0.41 clofazimine Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
bedaquiline Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.64 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.39 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 0.89 isoniazid Assoc w R High-level resistance
pncA 2288713 p.Thr177Pro missense_variant 0.65 pyrazinamide Assoc w R
pncA 2289030 p.His71Arg missense_variant 0.38 pyrazinamide Assoc w R
thyX 3067961 c.-16C>T upstream_gene_variant 0.64 para-aminosalicylic_acid Mutation from literature
embB 4247429 p.Met306Val missense_variant 0.25 ethambutol Assoc w R
embB 4247448 p.His312Arg missense_variant 0.58 ethambutol Mutation from literature
embB 4247663 p.Tyr384Asn missense_variant 0.25 ethambutol Mutation from literature
embB 4247676 p.Ala388Gly missense_variant 0.33 ethambutol Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.41 ethambutol Mutation from literature
ethA 4326699 c.774dupG frameshift_variant 0.54 ethionamide Assoc w R
gid 4408115 c.87delC frameshift_variant 0.43 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1038 c.1038A>T synonymous_variant 0.23 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.23 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.29 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.38 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.42 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.41 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.42 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.42 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.42 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.42 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.44 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.4 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.4 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.38 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.38 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.36 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.28 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.28 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
gyrB 5211 c.-29A>G upstream_gene_variant 0.56 moxifloxacin
levofloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.24 moxifloxacin
levofloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.26 moxifloxacin
levofloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.27 moxifloxacin
levofloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.27 moxifloxacin
levofloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.25 moxifloxacin
levofloxacin Uncertain significance
gyrA 6742 c.-560A>G upstream_gene_variant 0.25 moxifloxacin
levofloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.25 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.25 moxifloxacin
levofloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.26 moxifloxacin
levofloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.24 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.26 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.23 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.23 moxifloxacin
levofloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.22 moxifloxacin Not assoc w R - Interim
levofloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
gyrA 8219 c.918T>C synonymous_variant 0.22 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.22 moxifloxacin
levofloxacin
gyrA 8234 c.933T>C synonymous_variant 0.23 moxifloxacin
levofloxacin
gyrA 8237 c.936A>G synonymous_variant 0.22 moxifloxacin
levofloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.24 moxifloxacin
levofloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.26 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.31 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.31 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.31 moxifloxacin
levofloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.3 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.31 moxifloxacin
levofloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.37 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.42 moxifloxacin
levofloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.44 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.45 moxifloxacin
levofloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.52 moxifloxacin
levofloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.5 moxifloxacin
levofloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.51 moxifloxacin
levofloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.5 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.49 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
gyrA 9278 c.1977G>T synonymous_variant 0.55 moxifloxacin
levofloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.53 moxifloxacin
levofloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.53 moxifloxacin
levofloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.54 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.54 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.54 moxifloxacin
levofloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.53 moxifloxacin
levofloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.52 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.52 moxifloxacin
levofloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.38 moxifloxacin
levofloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.32 moxifloxacin
levofloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.32 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>G synonymous_variant 0.31 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9386 c.2085T>C synonymous_variant 0.29 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9389 c.2088C>T synonymous_variant 0.3 moxifloxacin
levofloxacin
gyrA 9395 c.2094G>C synonymous_variant 0.3 moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.31 moxifloxacin
levofloxacin
Rv0010c 13852 c.-294A>G upstream_gene_variant 0.21 isoniazid
Rv0010c 13860 c.-302A>G upstream_gene_variant 0.22 isoniazid
Rv0010c 13864 c.-306A>G upstream_gene_variant 0.22 isoniazid
Rv0010c 13876 c.-318G>C upstream_gene_variant 0.22 isoniazid
Rv0010c 13879 c.-321T>C upstream_gene_variant 0.21 isoniazid
Rv0010c 13897 c.-339C>T upstream_gene_variant 0.22 isoniazid
Rv0010c 13903 c.-345A>G upstream_gene_variant 0.22 isoniazid
fgd1 491203 p.Gln141Glu missense_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491289 c.507C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491292 c.510G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.28 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491302 p.Ile174Val missense_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491307 c.525C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491313 c.531C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491325 c.543G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491337 c.555C>G synonymous_variant 0.28 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.3 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491542 c.760T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491553 c.771G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491607 c.825G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491687 p.Thr302Lys missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491697 c.915G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 0.58 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 619507 c.-384A>G upstream_gene_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 619528 c.-363C>G upstream_gene_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356_-354delCAAinsGCG upstream_gene_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 619543 c.-348C>G upstream_gene_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 619561 c.-330G>C upstream_gene_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>C upstream_gene_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 619650 c.-241T>C upstream_gene_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>C synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620284 c.394_396delGCGinsCC frameshift_variant&missense_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>T synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620298 c.408G>C synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.6 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.49 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620424 c.534G>C synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620433 c.543C>G synonymous_variant 0.45 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620442 c.552G>C synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620460 c.570T>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620461 p.Val191Ile missense_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620481 c.591T>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620482 p.Val198Leu missense_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620490 c.600A>C synonymous_variant 0.21 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620583 c.693G>C synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620586 c.696C>G synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620598 c.708C>G synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620601 c.711C>T synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620613 c.723C>G synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620622 c.732G>C synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 0.49 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620631 c.741T>G synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620659 c.769_771delCGCinsAG frameshift_variant&missense_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620664 c.774C>T synonymous_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAA frameshift_variant&missense_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620763 c.873G>A synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620769 c.879C>G synonymous_variant 0.36 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>G synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620790 c.900C>T synonymous_variant 0.26 capreomycin
amikacin
kanamycin
Rv0565c 656166 c.1305C>G synonymous_variant 0.25 ethionamide
Rv0565c 656172 c.1299A>G synonymous_variant 0.27 ethionamide
Rv0565c 656179 p.Asp431Thr missense_variant 0.29 ethionamide
Rv0565c 656192 p.Asp427Asn missense_variant 0.36 ethionamide Uncertain significance
Rv0565c 656196 p.Leu425Arg missense_variant 0.37 ethionamide
Rv0565c 656219 p.His418Tyr missense_variant 0.42 ethionamide
Rv0565c 656220 c.1251A>C synonymous_variant 0.43 ethionamide
Rv0565c 656223 c.1248T>C synonymous_variant 0.44 ethionamide Not assoc w R - Interim
Rv0565c 656226 c.1243_1245delGCCinsTT frameshift_variant&missense_variant 0.43 ethionamide Uncertain significance
Rv0565c 656238 p.Ala411Glu missense_variant 0.42 ethionamide
Rv0565c 656243 p.Leu410Met missense_variant 0.41 ethionamide
Rv0565c 656244 c.1227A>C synonymous_variant 0.41 ethionamide
Rv0565c 656265 c.1206G>C synonymous_variant 0.41 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.41 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.42 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.43 ethionamide
Rv0565c 656298 c.1173G>C synonymous_variant 0.45 ethionamide
Rv0565c 656304 c.1167T>C synonymous_variant 0.44 ethionamide
Rv0565c 656325 c.1146C>G synonymous_variant 0.42 ethionamide
Rv0565c 656358 c.1113T>C synonymous_variant 0.31 ethionamide Not assoc w R - Interim
Rv0565c 656361 c.1110C>G synonymous_variant 0.32 ethionamide
Rv0565c 656364 c.1107T>C synonymous_variant 0.32 ethionamide
Rv0565c 656367 c.1101_1104delTCGGinsGC frameshift_variant&synonymous_variant 0.33 ethionamide Uncertain significance
Rv0565c 656371 p.Pro367His missense_variant 0.32 ethionamide
Rv0565c 656375 c.1095_1096insAA frameshift_variant 0.31 ethionamide Uncertain significance
Rv0565c 656383 p.Val363Asn missense_variant 0.33 ethionamide
Rv0565c 656391 c.1080C>G synonymous_variant 0.34 ethionamide
Rv0565c 656402 p.Ala357Thr missense_variant 0.37 ethionamide
Rv0565c 656412 c.1059T>G synonymous_variant 0.37 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.38 ethionamide
Rv0565c 656423 c.1048T>C synonymous_variant 0.39 ethionamide
Rv0565c 656448 c.1021_1023delATTinsGC frameshift_variant&missense_variant 0.4 ethionamide Uncertain significance
Rv0565c 656454 c.1017G>C synonymous_variant 0.41 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.41 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.39 ethionamide
Rv0565c 656475 c.996A>G synonymous_variant 0.35 ethionamide
Rv0565c 656484 c.987T>C synonymous_variant 0.29 ethionamide
Rv0565c 656487 c.984T>C synonymous_variant 0.29 ethionamide Not assoc w R - Interim
Rv0565c 656493 c.978C>G synonymous_variant 0.31 ethionamide
Rv0565c 656502 c.969C>T synonymous_variant 0.3 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.31 ethionamide Not assoc w R - Interim
Rv0565c 656526 p.Glu315Asp missense_variant 0.27 ethionamide
Rv0565c 656535 c.936C>G synonymous_variant 0.28 ethionamide
Rv0565c 656539 p.Ser311Ala missense_variant 0.26 ethionamide
Rv0565c 656542 p.Thr310Ser missense_variant 0.26 ethionamide
Rv0565c 656550 c.919_921delAACinsGG frameshift_variant&missense_variant 0.26 ethionamide Uncertain significance
Rv0565c 656568 c.903G>C synonymous_variant 0.22 ethionamide
Rv0565c 656904 c.567G>C synonymous_variant 0.2 ethionamide
Rv0565c 656924 p.Ile183Val missense_variant 0.24 ethionamide
Rv0565c 656936 p.Thr179Ala missense_variant 0.23 ethionamide
Rv0565c 656940 c.531C>T synonymous_variant 0.22 ethionamide Not assoc w R - Interim
Rv0565c 656946 c.525T>C synonymous_variant 0.24 ethionamide
Rv0565c 656952 c.519A>C synonymous_variant 0.24 ethionamide Not assoc w R - Interim
Rv0565c 656967 c.504T>C synonymous_variant 0.23 ethionamide
Rv0565c 656973 c.498A>G synonymous_variant 0.24 ethionamide
Rv0565c 656978 p.Ala165Thr missense_variant 0.24 ethionamide
Rv0565c 656982 p.Gly163Gln missense_variant 0.25 ethionamide
Rv0565c 656985 c.486T>C synonymous_variant 0.26 ethionamide
Rv0565c 656990 p.Lys161Glu missense_variant 0.25 ethionamide
Rv0565c 657000 p.Gly157Pro missense_variant 0.25 ethionamide
Rv0565c 657027 c.444T>C synonymous_variant 0.27 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 0.95 ethionamide Not assoc w R - Interim
Rv0565c 657138 c.331_333delGCAinsTG frameshift_variant&missense_variant 0.21 ethionamide Uncertain significance
Rv0565c 657142 p.Arg110His missense_variant 0.29 ethionamide Uncertain significance
Rv0565c 657144 c.327T>G synonymous_variant 0.24 ethionamide
Rv0565c 657155 p.Asn106Asp missense_variant 0.31 ethionamide
Rv0565c 657160 p.Glu104Arg missense_variant 0.29 ethionamide
Rv0565c 657171 c.300T>C synonymous_variant 0.32 ethionamide
Rv0565c 657187 p.His95Arg missense_variant 0.3 ethionamide
Rv0565c 657189 c.282C>G synonymous_variant 0.3 ethionamide
Rv0565c 657192 p.Met93Thr missense_variant 0.31 ethionamide
Rv0565c 657196 p.Asp92Ala missense_variant 0.33 ethionamide
Rv0565c 657200 p.Thr91Ala missense_variant 0.31 ethionamide Uncertain significance
Rv0565c 657201 c.270C>G synonymous_variant 0.31 ethionamide
Rv0565c 657219 p.Ala84Val missense_variant 0.4 ethionamide
Rv0565c 657231 c.238_240delATCinsGG frameshift_variant&missense_variant 0.46 ethionamide Uncertain significance
Rv0565c 657237 c.234A>G synonymous_variant 0.48 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.53 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.52 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.51 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.52 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.49 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.44 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.43 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.44 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.45 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.45 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.44 ethionamide
Rv0565c 657348 c.123A>G synonymous_variant 0.43 ethionamide
Rv0565c 657356 p.Ile39Val missense_variant 0.41 ethionamide
Rv0565c 657372 c.99G>C synonymous_variant 0.32 ethionamide
Rv0565c 657375 c.96C>T synonymous_variant 0.29 ethionamide
Rv0565c 657385 p.Ile29Thr missense_variant 0.25 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.25 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.28 ethionamide
Rv0565c 657680 c.-210G>C upstream_gene_variant 0.26 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.32 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.42 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.44 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.43 isoniazid
hadA 731687 c.-243_-242insCACAGATCTTTT upstream_gene_variant 0.41 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.42 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.42 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.4 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.41 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.43 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.48 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.5 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.46 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.41 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.3 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.28 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.22 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.21 isoniazid
hadA 732270 p.Glu114Val missense_variant 0.21 isoniazid
hadA 732272 p.Ala115Ser missense_variant 0.23 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.45 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.43 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.44 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.45 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.49 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.5 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.44 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.42 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.41 isoniazid
nusG 734173 c.-81C>G upstream_gene_variant 0.22 rifampicin
nusG 734176 c.-78G>T upstream_gene_variant 0.22 rifampicin
nusG 734180 c.-74T>G upstream_gene_variant 0.22 rifampicin Uncertain significance
nusG 734183 c.-71C>T upstream_gene_variant 0.21 rifampicin
nusG 734186 c.-68G>C upstream_gene_variant 0.21 rifampicin Uncertain significance
nusG 734205 c.-49A>C upstream_gene_variant 0.22 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.3 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.37 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.36 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.42 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.44 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.47 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.5 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.31 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.3 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 759746 c.-61C>T upstream_gene_variant 0.59 rifampicin Not assoc w R
rpoB 760091 c.285G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.33 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.4 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.46 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.54 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.63 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.65 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.67 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.68 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.71 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.72 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.73 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.75 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.74 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.6 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.55 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.53 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.56 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.38 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.27 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.29 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.5 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.5 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.51 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.61 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.62 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.59 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.6 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.66 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.68 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.66 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.68 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.62 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.58 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.51 rifampicin
rpoB 761373 p.Val523His missense_variant 0.51 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.39 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.22 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.25 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.35 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.41 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.61 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.63 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.54 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.42 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.34 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.36 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.35 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.36 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.36 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.36 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.58 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.58 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.54 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.54 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.54 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.58 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.62 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.63 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.64 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.61 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.58 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.62 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.61 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.61 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.6 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.54 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.51 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.52 rifampicin
rpoB 762413 c.2607G>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.54 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.63 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 0.27 rifampicin Not assoc w R
rpoB 762449 c.2643C>A synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.64 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.54 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.52 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.52 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.51 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.48 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.46 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.46 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.49 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.2 rifampicin
rpoB 762736 p.Ala977Asp missense_variant 0.21 rifampicin
rpoB 762745 p.Gln980Pro missense_variant 0.21 rifampicin
rpoB 762750 p.Leu982Met missense_variant 0.24 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762758 c.-612G>C upstream_gene_variant 0.33 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.43 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.44 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.43 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.49 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.48 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.49 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.68 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.7 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.31 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.74 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.74 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.72 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.69 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.67 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.66 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.64 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.55 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.55 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763284 c.-86C>T upstream_gene_variant 0.31 rifampicin
rpoC 763351 c.-19T>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoC 763352 c.-18T>A upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoC 763402 c.33C>G synonymous_variant 0.46 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.51 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.58 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.68 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.6 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.68 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.68 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.68 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.66 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.64 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.65 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.67 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.62 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.64 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.63 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.59 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.58 rifampicin
rpoC 763877 c.508_510delCTAinsTG frameshift_variant&stop_gained 0.58 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.59 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.6 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.61 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.59 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.59 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.6 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.59 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.61 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.63 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.61 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.61 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.62 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.62 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.63 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.61 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.63 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.59 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.62 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.63 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.66 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.71 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.69 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.7 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.69 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.79 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.69 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.68 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.68 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.69 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.68 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.69 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.67 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.72 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.75 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.74 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.73 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.68 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.68 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.68 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.75 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.71 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.64 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.53 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.53 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.46 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.42 rifampicin
rpoC 765292 c.1923G>C synonymous_variant 0.43 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.43 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.45 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.48 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.47 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.53 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.64 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.69 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.7 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.73 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.7 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.7 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.7 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.73 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.7 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.69 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.69 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.68 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.67 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.67 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.66 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.66 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.66 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.66 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.65 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.64 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.71 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.75 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.75 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.74 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.75 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.74 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.72 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.68 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.64 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.63 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.53 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.48 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766168 c.2799C>T synonymous_variant 0.38 rifampicin
rpoC 766174 p.Asn935Lys missense_variant 0.36 rifampicin
rpoC 766178 p.Ile937Val missense_variant 0.33 rifampicin
rpoC 766185 p.Glu939Ala missense_variant 0.29 rifampicin
rpoC 766189 c.2820T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766192 c.2823T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766193 c.2824_2826delCAAinsGG frameshift_variant&missense_variant 0.25 rifampicin
rpoC 766204 c.2835C>T synonymous_variant 0.25 rifampicin
rpoC 766207 c.2838T>C synonymous_variant 0.25 rifampicin
rpoC 766216 c.2847T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766237 c.2868T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766240 c.2871T>C synonymous_variant 0.22 rifampicin
rpoC 766243 c.2874C>G synonymous_variant 0.21 rifampicin
rpoC 766258 c.2889T>C synonymous_variant 0.3 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.3 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.29 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.34 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.37 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.49 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.54 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.59 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.61 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.65 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.69 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.72 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.7 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.7 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.71 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.69 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.66 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.63 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.63 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.65 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.65 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.64 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.64 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.62 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.61 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.57 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.55 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.54 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.54 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.53 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.58 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.59 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.61 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.62 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.61 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.67 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.67 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.66 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.64 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.7 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.73 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.77 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.74 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.7 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.71 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.66 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.68 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.55 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.5 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.41 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.34 rifampicin
rpoC 767275 c.3906T>C synonymous_variant 0.4 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.38 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>T synonymous_variant 0.4 rifampicin
rpoC 767288 c.3919C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 0.5 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpL5 776458 p.Ala675Thr missense_variant 0.47 clofazimine
bedaquiline
mmpS5 779615 c.-710C>G upstream_gene_variant 0.42 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.39 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.39 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.4 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.44 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.44 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.52 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.55 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.64 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.62 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.62 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.62 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.59 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.59 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.6 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.6 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.61 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.62 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.63 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.63 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.63 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.64 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.64 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.64 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.61 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.62 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.6 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.62 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.55 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.54 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.48 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.44 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.55 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.57 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.57 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.59 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.64 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.67 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.73 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.74 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.74 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.72 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.72 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.73 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.74 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.75 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.74 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.74 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.7 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.68 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.65 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.65 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.66 linezolid
rplC 800814 c.6A>G synonymous_variant 0.65 linezolid
rplC 800817 c.9A>T synonymous_variant 0.64 linezolid
rplC 800844 c.36T>C synonymous_variant 0.63 linezolid
rplC 800865 c.57A>G synonymous_variant 0.5 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.5 linezolid
rplC 800874 c.66A>G synonymous_variant 0.46 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.46 linezolid
rplC 800880 c.72A>G synonymous_variant 0.46 linezolid
rplC 800889 c.81C>G synonymous_variant 0.47 linezolid
rplC 800892 c.84G>C synonymous_variant 0.49 linezolid
rplC 800907 c.99C>G synonymous_variant 0.46 linezolid
rplC 800916 c.108A>G synonymous_variant 0.43 linezolid
rplC 800934 c.126C>G synonymous_variant 0.39 linezolid
rplC 800937 c.129A>G synonymous_variant 0.38 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.37 linezolid
rplC 800946 c.138T>C synonymous_variant 0.39 linezolid
rplC 800949 c.141T>C synonymous_variant 0.39 linezolid
rplC 800967 c.159C>G synonymous_variant 0.34 linezolid
rplC 800970 c.162T>C synonymous_variant 0.32 linezolid Not assoc w R - Interim
rplC 801246 c.438C>T synonymous_variant 0.23 linezolid
rplC 801249 c.441T>C synonymous_variant 0.25 linezolid
rplC 801255 c.447C>T synonymous_variant 0.25 linezolid
rplC 801264 c.456C>T synonymous_variant 0.24 linezolid
rplC 801267 c.459A>T synonymous_variant 0.25 linezolid
rplC 801270 c.462T>C synonymous_variant 0.23 linezolid
rplC 801276 c.468G>C synonymous_variant 0.23 linezolid
rplC 801279 c.471G>C synonymous_variant 0.23 linezolid
rplC 801282 c.474G>C synonymous_variant 0.24 linezolid
rplC 801285 c.477G>C synonymous_variant 0.25 linezolid
rplC 801300 c.492C>G synonymous_variant 0.33 linezolid
rplC 801309 c.501C>G synonymous_variant 0.34 linezolid
rplC 801312 c.504G>C synonymous_variant 0.35 linezolid
rplC 801321 c.513C>T synonymous_variant 0.4 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.41 linezolid
rplC 801339 c.531T>C synonymous_variant 0.38 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.38 linezolid
rplC 801348 c.540T>G synonymous_variant 0.38 linezolid
rplC 801357 c.549T>C synonymous_variant 0.38 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.37 linezolid
rplC 801402 c.594T>C synonymous_variant 0.44 linezolid
rplC 801405 c.597T>C synonymous_variant 0.43 linezolid
rplC 801423 c.615G>C synonymous_variant 0.47 linezolid
rplC 801426 c.618C>G synonymous_variant 0.48 linezolid
rplC 801427 p.Met207Val missense_variant 0.48 linezolid
rplC 801438 c.630T>C synonymous_variant 0.47 linezolid
rplC 801442 p.Ile212Val missense_variant 0.48 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.98 isoniazid Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
levofloxacin Not assoc w R
fbiC 1303509 c.579G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303521 c.591C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303654 c.724C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303663 c.733C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303668 c.738C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303671 c.741C>T synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.5 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304511 c.1581C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304535 c.1605G>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.31 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305210 c.2280G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305215 p.Ser762Thr missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305231 c.2301C>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305234 c.2304G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305240 c.2310T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305243 c.2313T>G synonymous_variant 0.28 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305244 c.2314T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305279 p.His783Gln missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305309 c.2379G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305310 p.Arg794Glu missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305318 c.2388C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305372 c.2442G>A synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305384 c.2454G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305396 c.2466C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
sigE 1364805 c.393C>G synonymous_variant 0.21 pyrazinamide
sigE 1364814 c.402C>G synonymous_variant 0.3 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.3 pyrazinamide
sigE 1364839 c.427_429delTTGinsCC frameshift_variant&missense_variant 0.29 pyrazinamide Uncertain significance
sigE 1364847 c.435G>C synonymous_variant 0.29 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.28 pyrazinamide
sigE 1364862 c.450C>A synonymous_variant 0.26 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.25 pyrazinamide
sigE 1364868 c.456T>G synonymous_variant 0.27 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.26 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.24 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.24 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.24 pyrazinamide
sigE 1364943 c.531C>T synonymous_variant 0.2 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 0.46 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1460816 c.-229T>C upstream_gene_variant 0.29 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.28 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.28 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.27 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.27 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.28 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.28 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.29 bedaquiline
atpE 1460894 c.-151A>G upstream_gene_variant 0.27 bedaquiline
atpE 1460897 c.-148A>C upstream_gene_variant 0.26 bedaquiline
atpE 1460900 c.-145T>C upstream_gene_variant 0.25 bedaquiline
atpE 1460915 c.-130C>G upstream_gene_variant 0.27 bedaquiline
atpE 1460918 c.-127A>G upstream_gene_variant 0.27 bedaquiline
atpE 1461089 c.45G>C synonymous_variant 0.31 bedaquiline
atpE 1461097 p.Ala18Gly missense_variant 0.36 bedaquiline
atpE 1461101 c.57T>C synonymous_variant 0.36 bedaquiline
atpE 1461107 c.63C>G synonymous_variant 0.43 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.47 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.61 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.63 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.63 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.61 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.61 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.62 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.64 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.64 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.64 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.57 bedaquiline
atpE 1461251 c.207G>C synonymous_variant 0.46 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.44 bedaquiline
atpE 1461275 c.231T>A synonymous_variant 0.25 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
amikacin
streptomycin
capreomycin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin Uncertain significance
capreomycin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin
capreomycin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.3 kanamycin
amikacin
streptomycin
capreomycin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.32 kanamycin
amikacin Uncertain significance
streptomycin Uncertain significance
capreomycin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin
capreomycin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin Uncertain significance
capreomycin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin
capreomycin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.42 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin Uncertain significance
capreomycin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.76 kanamycin
amikacin
streptomycin
capreomycin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin Uncertain significance
capreomycin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin
capreomycin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin
capreomycin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin Uncertain significance
capreomycin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin
capreomycin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.71 kanamycin
amikacin
streptomycin
capreomycin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin Uncertain significance
capreomycin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin Uncertain significance
capreomycin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin
capreomycin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.75 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.65 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.58 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673941 c.-261G>T upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.3 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.33 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.37 ethionamide
isoniazid
inhA 1674006 c.-196T>G upstream_gene_variant 0.39 ethionamide
isoniazid
inhA 1674015 c.-187C>T upstream_gene_variant 0.3 ethionamide
isoniazid Uncertain significance
inhA 1674018 c.-184G>C upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1674021 c.-181G>C upstream_gene_variant 0.3 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.32 ethionamide
isoniazid
inhA 1674033 c.-169T>C upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1674037 c.-165_-164delCAinsGC upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1674042 c.-160G>T upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1674049 c.-153_-151delCAAinsGC upstream_gene_variant 0.31 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.3 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.3 ethionamide
isoniazid
inhA 1674063 c.-139G>C upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1674079 c.-123C>G upstream_gene_variant 0.27 ethionamide
isoniazid
rpsA 1833532 c.-10A>C upstream_gene_variant 0.34 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.42 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.59 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.6 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.72 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.73 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.7 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.7 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.71 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.7 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.7 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.7 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.67 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.67 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.67 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.67 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.64 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.65 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.67 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.68 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.66 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.69 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.72 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.68 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.69 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.67 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.65 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.64 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.55 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.55 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.55 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.56 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.45 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.47 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.5 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.56 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.45 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.47 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.28 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.31 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.35 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.3 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.2 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.41 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.38 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.36 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.33 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.3 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.24 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.22 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 0.97 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064882 c.-154C>G upstream_gene_variant 0.25 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064892 c.-164A>G upstream_gene_variant 0.31 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064897 c.-169C>G upstream_gene_variant 0.32 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064903 c.-175G>A upstream_gene_variant 0.34 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064912 c.-184A>G upstream_gene_variant 0.36 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064915 c.-187G>C upstream_gene_variant 0.36 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064933 c.-205A>G upstream_gene_variant 0.42 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064936 c.-208C>G upstream_gene_variant 0.43 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064942 c.-214G>A upstream_gene_variant 0.46 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064948 c.-220G>C upstream_gene_variant 0.46 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064972 c.-244T>C upstream_gene_variant 0.52 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064978 c.-250G>C upstream_gene_variant 0.52 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064979 c.-251C>T upstream_gene_variant 0.53 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064984 c.-256A>G upstream_gene_variant 0.53 kanamycin
amikacin
streptomycin
capreomycin
bacA 2064993 c.-265T>C upstream_gene_variant 0.56 kanamycin
amikacin
streptomycin
capreomycin
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155661 p.Val151Ile missense_variant 0.25 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.26 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.27 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.26 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.27 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.25 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.27 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.26 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.27 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.26 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 0.4 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 0.68 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.58 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.38 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.35 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.28 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.3 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.29 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.31 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.34 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.33 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.32 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.34 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.34 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.36 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.38 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.4 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.41 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.45 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.45 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.45 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.45 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.45 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.44 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.4 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.39 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.35 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.36 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.28 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.23 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.27 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.28 isoniazid
kasA 2519196 p.Thr361Ser missense_variant 0.28 isoniazid
kasA 2519215 c.1101C>T synonymous_variant 0.28 isoniazid
kasA 2519218 c.1104G>A synonymous_variant 0.28 isoniazid
kasA 2519221 c.1107G>C synonymous_variant 0.28 isoniazid
kasA 2519227 c.1113G>C synonymous_variant 0.29 isoniazid
kasA 2519230 c.1116C>T synonymous_variant 0.28 isoniazid
kasA 2519236 c.1122G>A synonymous_variant 0.27 isoniazid
kasA 2519239 c.1125A>C synonymous_variant 0.28 isoniazid
kasA 2519245 c.1131T>C synonymous_variant 0.26 isoniazid
kasA 2519263 c.1149C>T synonymous_variant 0.23 isoniazid
kasA 2519281 c.1167G>T synonymous_variant 0.2 isoniazid
kasA 2519295 p.Tyr394Phe missense_variant 0.21 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 0.56 isoniazid Not assoc w R
folC 2746438 c.1161G>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2746451 p.Gly383Ala missense_variant 0.21 para-aminosalicylic_acid
folC 2746471 c.1128C>A synonymous_variant 0.21 para-aminosalicylic_acid
folC 2746478 p.Phe374Tyr missense_variant 0.22 para-aminosalicylic_acid
folC 2746496 p.His368Arg missense_variant 0.21 para-aminosalicylic_acid
folC 2746510 c.1089A>G synonymous_variant 0.22 para-aminosalicylic_acid
folC 2746516 c.1083T>G synonymous_variant 0.22 para-aminosalicylic_acid
folC 2746520 p.Ser360Ala missense_variant 0.22 para-aminosalicylic_acid
folC 2746525 c.1074G>T synonymous_variant 0.22 para-aminosalicylic_acid
folC 2746534 c.1065T>C synonymous_variant 0.27 para-aminosalicylic_acid
folC 2746558 c.1041G>T synonymous_variant 0.19 para-aminosalicylic_acid
folC 2746564 c.1035A>G synonymous_variant 0.21 para-aminosalicylic_acid
Rv2477c 2782498 c.1545C>T synonymous_variant 0.46 kanamycin Not assoc w R
moxifloxacin Not assoc w R
amikacin Not assoc w R
rifampicin Not assoc w R
streptomycin Not assoc w R - Interim
ethambutol Not assoc w R
levofloxacin Not assoc w R
Rv2477c 2783149 c.894G>C synonymous_variant 0.24 kanamycin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
amikacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin
ethambutol
levofloxacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.24 kanamycin Not assoc w R - Interim
moxifloxacin
amikacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin
ethambutol Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.3 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.31 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.33 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.35 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.35 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.35 kanamycin
moxifloxacin Not assoc w R - Interim
amikacin
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
Rv2477c 2783235 c.808T>C synonymous_variant 0.34 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.38 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.42 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.37 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.38 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.35 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.34 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.33 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.31 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.31 kanamycin
moxifloxacin
amikacin
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.3 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.25 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.23 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.24 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.33 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.34 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.45 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.46 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.46 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.48 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.47 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.47 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.49 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.5 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.5 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.49 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.51 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.52 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.54 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.58 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.55 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.59 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.59 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.6 kanamycin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
amikacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.71 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.75 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.76 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.77 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.77 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.69 kanamycin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
amikacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.68 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.66 kanamycin
moxifloxacin
amikacin
rifampicin
streptomycin
ethambutol
levofloxacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.61 kanamycin Not assoc w R - Interim
moxifloxacin
amikacin
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
Rv2752c 3064893 c.1299C>G synonymous_variant 0.22 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3064896 c.1296T>C synonymous_variant 0.24 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3064914 c.1278T>G synonymous_variant 0.27 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3064926 c.1264_1266delTTGinsCC frameshift_variant&missense_variant 0.26 isoniazid Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
levofloxacin Uncertain significance
Rv2752c 3064932 c.1260T>C synonymous_variant 0.26 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3064935 c.1257A>G synonymous_variant 0.26 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3064941 c.1249_1251delCAAinsGG frameshift_variant&missense_variant 0.27 isoniazid Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
levofloxacin Uncertain significance
Rv2752c 3064947 c.1245A>G synonymous_variant 0.27 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3064956 c.1234_1236delAGTinsCC frameshift_variant&missense_variant 0.27 isoniazid Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
levofloxacin Uncertain significance
Rv2752c 3064962 c.1230C>G synonymous_variant 0.29 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3064973 p.Ala407Ser missense_variant 0.28 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3064974 c.1218T>C synonymous_variant 0.29 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065028 c.1162_1164delGTGinsAC frameshift_variant&missense_variant 0.43 isoniazid Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
levofloxacin Uncertain significance
Rv2752c 3065040 c.1152C>G synonymous_variant 0.51 isoniazid Not assoc w R - Interim
moxifloxacin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin
Rv2752c 3065048 c.1144C>T synonymous_variant 0.46 isoniazid Not assoc w R - Interim
moxifloxacin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin
Rv2752c 3065052 c.1140G>A synonymous_variant 0.44 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065055 c.1137T>C synonymous_variant 0.44 isoniazid Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
Rv2752c 3065064 c.1128G>C synonymous_variant 0.44 isoniazid Not assoc w R - Interim
moxifloxacin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin
Rv2752c 3065073 c.1119C>G synonymous_variant 0.41 isoniazid Not assoc w R - Interim
moxifloxacin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin
Rv2752c 3065079 c.1113T>C synonymous_variant 0.41 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065082 c.1110G>C synonymous_variant 0.42 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065085 c.1105_1107delAGGinsCC frameshift_variant&missense_variant 0.4 isoniazid Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
levofloxacin Uncertain significance
Rv2752c 3065088 c.1104A>G synonymous_variant 0.41 isoniazid Not assoc w R - Interim
moxifloxacin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
Rv2752c 3065109 c.1081_1083delAGAinsCC frameshift_variant&missense_variant 0.47 isoniazid Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
levofloxacin Uncertain significance
Rv2752c 3065115 c.1077C>G synonymous_variant 0.45 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065126 p.Ser356Ala missense_variant 0.44 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065127 c.1065G>C synonymous_variant 0.44 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065130 p.Ala354Glu missense_variant 0.43 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065133 c.1059T>C synonymous_variant 0.47 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065142 c.1050A>C synonymous_variant 0.53 isoniazid Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.54 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065151 c.1041G>C synonymous_variant 0.53 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065183 p.Ser337Ala missense_variant 0.36 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065186 c.1006T>C synonymous_variant 0.34 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065190 c.1000_1002delATCinsGG frameshift_variant&missense_variant 0.33 isoniazid Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
levofloxacin Uncertain significance
Rv2752c 3065196 c.996T>C synonymous_variant 0.35 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065202 c.990T>G synonymous_variant 0.37 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065205 c.987T>C synonymous_variant 0.37 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065210 c.982T>C synonymous_variant 0.38 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065223 c.969T>C synonymous_variant 0.42 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065229 c.963G>C synonymous_variant 0.42 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065232 c.960T>C synonymous_variant 0.42 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065241 c.951A>G synonymous_variant 0.38 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065262 c.930G>A synonymous_variant 0.36 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065268 c.924A>G synonymous_variant 0.41 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065288 c.904T>C synonymous_variant 0.31 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065292 c.900T>C synonymous_variant 0.29 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065295 p.Gln299Arg missense_variant 0.28 isoniazid Uncertain significance
moxifloxacin
rifampicin Uncertain significance
ethambutol Uncertain significance
levofloxacin
Rv2752c 3065298 p.Asp298Glu missense_variant 0.28 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065306 p.Ala296Pro missense_variant 0.3 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065311 p.Thr294Met missense_variant 0.3 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065313 c.879A>G synonymous_variant 0.3 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065323 p.Ala290Gly missense_variant 0.33 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065334 c.856_858delCTCinsGG frameshift_variant&missense_variant 0.34 isoniazid Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
levofloxacin Uncertain significance
Rv2752c 3065337 c.855T>C synonymous_variant 0.34 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065346 c.846T>G synonymous_variant 0.31 isoniazid Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
Rv2752c 3065352 c.840A>G synonymous_variant 0.31 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065355 c.837A>G synonymous_variant 0.3 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065364 c.828G>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
moxifloxacin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin
Rv2752c 3065367 c.823_825delCAAinsGG frameshift_variant&missense_variant 0.26 isoniazid Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
levofloxacin Uncertain significance
Rv2752c 3065372 c.820A>C synonymous_variant 0.26 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065373 c.819A>C synonymous_variant 0.26 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065378 p.Val272Ile missense_variant 0.26 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065381 p.Arg271Gly missense_variant 0.28 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065397 c.795G>C synonymous_variant 0.27 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065400 c.792A>C synonymous_variant 0.27 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065915 c.277C>T synonymous_variant 0.28 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065925 p.Ala89Gly missense_variant 0.27 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065928 c.264G>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
moxifloxacin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin
Rv2752c 3065946 p.Gly82Ala missense_variant 0.33 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065955 c.235_237delTTGinsCC frameshift_variant&missense_variant 0.39 isoniazid Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
levofloxacin Uncertain significance
Rv2752c 3065979 c.213T>C synonymous_variant 0.56 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3065993 p.Val67Ile missense_variant 0.62 isoniazid Uncertain significance
moxifloxacin
rifampicin Uncertain significance
ethambutol Uncertain significance
levofloxacin
Rv2752c 3065994 c.198T>C synonymous_variant 0.63 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066002 p.Met64Leu missense_variant 0.65 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066009 c.183G>C synonymous_variant 0.65 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066018 c.174T>C synonymous_variant 0.65 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066024 c.168T>G synonymous_variant 0.65 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066040 p.Gly51Thr missense_variant 0.58 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066042 c.150T>C synonymous_variant 0.57 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066045 c.147T>C synonymous_variant 0.58 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066050 p.Leu48Met missense_variant 0.58 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066054 c.138T>G synonymous_variant 0.59 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066066 c.126T>C synonymous_variant 0.57 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066075 c.117A>G synonymous_variant 0.56 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066118 p.Asn25Ser missense_variant 0.44 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066237 c.-46C>G upstream_gene_variant 0.22 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066249 c.-58C>T upstream_gene_variant 0.32 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066261 c.-70G>C upstream_gene_variant 0.34 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066270 c.-79G>A upstream_gene_variant 0.35 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066276 c.-85G>A upstream_gene_variant 0.32 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066279 c.-88A>G upstream_gene_variant 0.33 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066282 c.-91G>T upstream_gene_variant 0.33 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066287 c.-96G>C upstream_gene_variant 0.33 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066290 c.-99G>A upstream_gene_variant 0.33 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066291 c.-100G>A upstream_gene_variant 0.33 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066309 c.-118T>C upstream_gene_variant 0.38 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066315 c.-124C>T upstream_gene_variant 0.39 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066330 c.-139G>C upstream_gene_variant 0.38 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066335 c.-144T>C upstream_gene_variant 0.38 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066339 c.-148G>C upstream_gene_variant 0.38 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066360 c.-169T>C upstream_gene_variant 0.41 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066370 c.-180_-179delAGinsGC upstream_gene_variant 0.48 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066380 c.-189A>G upstream_gene_variant 0.51 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066396 c.-207_-205delGCGinsAC upstream_gene_variant 0.39 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066399 c.-210_-208delATTinsTCC upstream_gene_variant 0.4 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066432 c.-241T>C upstream_gene_variant 0.48 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066435 c.-246_-244delGGTinsAAC upstream_gene_variant 0.47 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066452 c.-261T>A upstream_gene_variant 0.42 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066453 c.-262G>A upstream_gene_variant 0.42 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066456 c.-265A>G upstream_gene_variant 0.4 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066462 c.-271G>A upstream_gene_variant 0.4 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066465 c.-276_-274delGGGinsAAT upstream_gene_variant 0.39 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066471 c.-280A>G upstream_gene_variant 0.41 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066476 c.-285C>G upstream_gene_variant 0.41 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066482 c.-291G>T upstream_gene_variant 0.42 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066483 c.-292T>C upstream_gene_variant 0.4 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.48 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.46 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.47 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.44 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066561 c.-370A>G upstream_gene_variant 0.4 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.37 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.38 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.39 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066583 c.-392C>G upstream_gene_variant 0.41 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.46 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066617 c.-426G>A upstream_gene_variant 0.47 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066618 c.-427A>G upstream_gene_variant 0.46 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066633 c.-442T>C upstream_gene_variant 0.44 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066638 c.-447T>G upstream_gene_variant 0.4 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066642 c.-453_-451delTTGinsCC upstream_gene_variant 0.37 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066654 c.-463G>C upstream_gene_variant 0.37 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066657 c.-466C>G upstream_gene_variant 0.34 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066665 c.-474G>C upstream_gene_variant 0.34 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066704 c.-513C>G upstream_gene_variant 0.25 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066707 c.-516A>G upstream_gene_variant 0.24 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066714 c.-523G>A upstream_gene_variant 0.23 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066734 c.-543G>A upstream_gene_variant 0.36 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066744 c.-553C>G upstream_gene_variant 0.28 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066747 c.-558_-556delCAAinsATC upstream_gene_variant 0.28 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066756 c.-567_-565delCGGinsAC upstream_gene_variant 0.31 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066762 c.-571G>C upstream_gene_variant 0.31 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066771 c.-580C>G upstream_gene_variant 0.3 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.31 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066780 c.-589C>G upstream_gene_variant 0.3 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.29 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066810 c.-619G>A upstream_gene_variant 0.28 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.36 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.37 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.38 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066855 c.-664T>C upstream_gene_variant 0.37 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066864 c.-673C>G upstream_gene_variant 0.34 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066867 c.-676T>C upstream_gene_variant 0.33 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066876 c.-685T>C upstream_gene_variant 0.28 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066879 c.-688T>C upstream_gene_variant 0.26 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066891 c.-700G>C upstream_gene_variant 0.25 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066900 c.-709A>G upstream_gene_variant 0.25 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066905 c.-714T>C upstream_gene_variant 0.23 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066906 c.-715C>G upstream_gene_variant 0.24 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066910 c.-719C>T upstream_gene_variant 0.23 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066912 c.-721G>C upstream_gene_variant 0.23 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066933 c.-743_-742delGGinsAC upstream_gene_variant 0.22 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066960 c.-769C>G upstream_gene_variant 0.28 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
Rv2752c 3066981 c.-790T>G upstream_gene_variant 0.21 isoniazid
moxifloxacin
rifampicin
ethambutol
levofloxacin
thyX 3067223 c.723G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067232 c.714C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067246 p.Thr234Ala missense_variant 0.38 para-aminosalicylic_acid
thyX 3067249 p.Thr233Ser missense_variant 0.35 para-aminosalicylic_acid
thyX 3067250 c.694_696delGTGinsAC frameshift_variant&missense_variant 0.33 para-aminosalicylic_acid
thyX 3067274 c.672C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067277 c.669C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067281 p.Val222Ala missense_variant 0.41 para-aminosalicylic_acid
thyX 3067284 p.Ala221Gly missense_variant 0.41 para-aminosalicylic_acid
thyX 3067286 c.660C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067292 c.654G>A synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067295 c.651C>T synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067328 c.618G>A synonymous_variant 0.6 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.6 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.61 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.64 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.66 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.71 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.72 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.69 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.66 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.66 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.66 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.65 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.64 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.62 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.62 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.61 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.6 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.57 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.57 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.54 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.56 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.49 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067736 c.208_210delTTCinsCT frameshift_variant&missense_variant 0.52 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.5 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.51 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.59 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.54 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.51 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.48 para-aminosalicylic_acid
thyX 3067935 p.Thr4Ile missense_variant 0.32 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.27 para-aminosalicylic_acid
thyA 3074055 p.Glu139Pro missense_variant 0.26 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074100 c.370_372delGATinsAC frameshift_variant&synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.23 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3449354 c.852dupC frameshift_variant 0.45 ethionamide Uncertain significance
Rv3236c 3612813 p.Thr102Ala missense_variant 0.5 pyrazinamide Not assoc w R - Interim
lpqB 3624077 c.834G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624082 c.829A>C synonymous_variant 0.29 rifampicin
bedaquiline
lpqB 3624086 c.825C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624092 c.817_819delAGGinsCC frameshift_variant&missense_variant 0.28 rifampicin Uncertain significance
bedaquiline
lpqB 3624100 c.811T>C synonymous_variant 0.29 rifampicin
bedaquiline
lpqB 3624101 c.810C>G synonymous_variant 0.29 rifampicin
bedaquiline
lpqB 3624107 c.804C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624116 c.795A>G synonymous_variant 0.32 rifampicin
bedaquiline
lpqB 3624119 c.792C>G synonymous_variant 0.31 rifampicin
bedaquiline
lpqB 3624124 p.Leu263Val missense_variant 0.31 rifampicin
bedaquiline
lpqB 3624125 c.786A>G synonymous_variant 0.31 rifampicin
bedaquiline
lpqB 3624143 c.768T>C synonymous_variant 0.38 rifampicin
bedaquiline
lpqB 3624166 p.Met249Leu missense_variant 0.41 rifampicin
bedaquiline
lpqB 3624167 c.744C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624173 c.738A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624179 c.732C>G synonymous_variant 0.42 rifampicin
bedaquiline
lpqB 3624185 c.726C>T synonymous_variant 0.41 rifampicin
bedaquiline
lpqB 3624194 c.717C>G synonymous_variant 0.4 rifampicin
bedaquiline
lpqB 3624200 c.711A>G synonymous_variant 0.34 rifampicin
bedaquiline
lpqB 3624204 p.Ser236Asn missense_variant 0.31 rifampicin
bedaquiline
lpqB 3624209 c.702A>C synonymous_variant 0.29 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625549 c.-639G>A upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3625569 c.1045T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.26 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.29 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.34 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.35 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.37 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.34 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.32 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625749 c.-839C>T upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.22 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.23 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 0.54 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626704 c.-91C>T upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3626711 c.-98T>C upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrA 3626723 c.627C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3626729 c.-116G>A upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.59 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.62 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.66 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.67 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.7 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.7 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.71 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.71 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.7 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.71 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.72 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.71 rifampicin
bedaquiline
mtrA 3626895 p.Ile152Asn missense_variant 0.21 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.72 rifampicin
bedaquiline
mtrB 3626912 c.-299T>G upstream_gene_variant 0.72 rifampicin
bedaquiline
mtrB 3626927 c.-314G>C upstream_gene_variant 0.75 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.75 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.76 rifampicin
bedaquiline
mtrB 3626957 c.-344G>C upstream_gene_variant 0.75 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.79 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.81 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.83 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.83 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.77 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.77 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.76 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.75 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.71 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.68 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.66 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.66 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.67 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.69 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.68 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.68 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.65 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.64 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.64 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.64 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.58 rifampicin
bedaquiline
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.57 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.56 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.56 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.46 rifampicin
bedaquiline
mtrB 3627360 c.-747G>C upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3627375 c.-762C>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627377 c.-764G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627380 c.-767T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
fbiB 3642617 c.1083C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiB 3642620 c.1086T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiB 3642659 c.1125C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiB 3642668 c.1134A>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiB 3642680 c.1146A>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiB 3642719 c.1185T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiB 3642731 c.1197C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiB 3642743 c.1209T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiB 3642749 c.1215T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiB 3642758 c.1224C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiB 3642763 p.Asp410Ala missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiB 3642770 c.1236G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiB 3642779 c.1245A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiB 3642781 p.Val416Ala missense_variant 0.25 clofazimine
pretomanid
delamanid
alr 3841473 c.-53G>A upstream_gene_variant 0.58 cycloserine
rpoA 3877494 p.Glu338Asp missense_variant 0.27 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.29 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.33 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.34 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.52 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.55 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.63 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.62 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.61 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.6 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.58 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.58 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.53 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877824 c.684G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.36 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.29 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.23 rifampicin
rpoA 3878352 c.156C>G synonymous_variant 0.23 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.24 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.24 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.39 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.39 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.4 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.41 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.42 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.42 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.44 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.45 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.43 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.42 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.42 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.4 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.38 rifampicin
rpoA 3878935 c.-428C>T upstream_gene_variant 0.21 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.2 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878953 c.-446C>T upstream_gene_variant 0.26 rifampicin
rpoA 3878956 c.-449G>T upstream_gene_variant 0.28 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.3 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.29 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.38 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.43 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.46 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.59 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.57 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.6 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.64 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.64 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.62 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.61 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.6 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.55 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.47 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.47 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.46 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.48 rifampicin
clpC1 4038212 c.2493T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038239 c.2466T>C synonymous_variant 0.49 pyrazinamide
clpC1 4038255 p.Val817Lys missense_variant 0.47 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.45 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.44 pyrazinamide
clpC1 4038275 c.2430A>G synonymous_variant 0.44 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.53 pyrazinamide
clpC1 4038308 c.2397G>T synonymous_variant 0.52 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.51 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.52 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.48 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.49 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.48 pyrazinamide
clpC1 4038398 c.2307G>C synonymous_variant 0.49 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.5 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.5 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.48 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.48 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.53 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.55 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.55 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.55 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.56 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.55 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.6 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.59 pyrazinamide
clpC1 4038541 c.2164C>T synonymous_variant 0.6 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.53 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.47 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.5 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.48 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.45 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.47 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.5 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.51 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.5 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.49 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.51 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.59 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.58 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.59 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.6 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.59 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.6 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.6 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.64 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.66 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.66 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.66 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.65 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.65 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.65 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.66 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.66 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.63 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.54 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.34 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039241 c.1464G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.52 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.54 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.56 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.57 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.59 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.57 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.57 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.55 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.53 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.58 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.57 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.34 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039682 c.1023C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039700 c.1005C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039724 c.981A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.33 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.55 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.63 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4039988 c.717C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039994 c.711G>A synonymous_variant 0.53 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.48 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.45 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.29 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.23 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040300 c.405C>A synonymous_variant 0.2 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040339 c.366G>A synonymous_variant 0.31 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.41 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.42 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.44 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.43 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.42 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.46 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.54 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.56 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.57 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.57 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.56 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.53 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>T synonymous_variant 0.45 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.46 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.38 pyrazinamide
clpC1 4040567 c.138C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
panD 4044693 c.-412C>A upstream_gene_variant 0.35 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 0.6 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.2 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.22 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.25 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.26 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.26 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.32 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.31 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.3 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.33 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.32 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.32 pyrazinamide
panD 4045088 c.-807T>C upstream_gene_variant 0.29 pyrazinamide
panD 4045094 c.-813T>C upstream_gene_variant 0.26 pyrazinamide
panD 4045097 c.-816T>C upstream_gene_variant 0.24 pyrazinamide
panD 4045105 c.-824T>C upstream_gene_variant 0.23 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 0.46 isoniazid Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
streptomycin Not assoc w R - Interim
ethambutol Not assoc w R
levofloxacin Not assoc w R
glpK 4138625 c.1131G>C synonymous_variant 0.32 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138643 c.1113A>C synonymous_variant 0.41 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138646 c.1110G>C synonymous_variant 0.39 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138654 c.1102C>T synonymous_variant 0.46 isoniazid Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.47 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.47 isoniazid Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
ethambutol Uncertain significance
levofloxacin Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.51 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138718 c.1038T>C synonymous_variant 0.57 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138721 c.1035G>A synonymous_variant 0.57 isoniazid Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin
ethambutol Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.56 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138730 c.1026C>G synonymous_variant 0.56 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138757 c.999A>G synonymous_variant 0.56 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138763 c.993G>A synonymous_variant 0.56 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138769 c.987G>C synonymous_variant 0.58 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138774 p.Ser328Ala missense_variant 0.59 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138778 c.978C>G synonymous_variant 0.57 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138796 c.960A>G synonymous_variant 0.6 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138802 c.954G>A synonymous_variant 0.57 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138808 c.948G>T synonymous_variant 0.56 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138817 c.939T>C synonymous_variant 0.58 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138822 p.Asn312Asp missense_variant 0.57 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138829 c.927A>G synonymous_variant 0.55 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138838 c.918G>C synonymous_variant 0.48 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138841 c.915G>C synonymous_variant 0.47 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138847 c.909A>G synonymous_variant 0.47 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138853 c.903C>G synonymous_variant 0.46 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138859 c.895_897delAATinsGC frameshift_variant&missense_variant 0.4 isoniazid Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
ethambutol Uncertain significance
levofloxacin Uncertain significance
glpK 4138862 c.894G>C synonymous_variant 0.39 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138865 c.891A>G synonymous_variant 0.39 isoniazid Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
glpK 4138877 c.879A>G synonymous_variant 0.39 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138880 c.876T>C synonymous_variant 0.36 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
glpK 4138892 c.864G>A synonymous_variant 0.33 isoniazid Not assoc w R - Interim
moxifloxacin
rifampicin Not assoc w R - Interim
streptomycin
ethambutol Not assoc w R - Interim
levofloxacin
glpK 4138898 c.858T>C synonymous_variant 0.27 isoniazid
moxifloxacin
rifampicin
streptomycin
ethambutol
levofloxacin
embC 4240726 c.864G>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.43 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.44 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.46 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.53 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.54 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.55 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.43 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.42 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.4 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.38 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.38 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.35 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.3 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.3 ethambutol
embC 4240903 c.1041C>G synonymous_variant 0.3 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.3 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.29 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.28 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.26 ethambutol
embC 4240945 c.1083T>G synonymous_variant 0.23 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.2 ethambutol
embC 4241022 p.Ala387Val missense_variant 0.33 ethambutol Uncertain significance
embC 4241089 c.1227C>G synonymous_variant 0.27 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.26 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.25 ethambutol
embC 4242075 p.Arg738Gln missense_variant 0.48 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.51 ethambutol Not assoc w R
embA 4245282 p.Ile684Val missense_variant 0.21 ethambutol
embA 4245290 c.2058C>G synonymous_variant 0.21 ethambutol
embA 4245293 c.2061T>G synonymous_variant 0.21 ethambutol
embA 4245296 c.2064G>C synonymous_variant 0.22 ethambutol
embA 4245299 c.2067A>G synonymous_variant 0.21 ethambutol
embB 4245557 c.-957G>A upstream_gene_variant 0.25 ethambutol
embB 4245659 c.-855C>G upstream_gene_variant 0.26 ethambutol
embA 4245674 c.2442A>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4245677 c.-837G>C upstream_gene_variant 0.29 ethambutol
embA 4245693 p.Ile821Val missense_variant 0.24 ethambutol
embB 4245725 c.-789A>G upstream_gene_variant 0.35 ethambutol
embB 4245726 c.-788T>C upstream_gene_variant 0.34 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.49 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.51 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.52 ethambutol
embA 4245772 p.Asn847Thr missense_variant 0.5 ethambutol
embA 4245785 c.2553G>C synonymous_variant 0.57 ethambutol Not assoc w R - Interim
embA 4245807 c.2575_2577delTTAinsCG frameshift_variant&missense_variant 0.56 ethambutol Uncertain significance
embB 4245812 c.-702G>C upstream_gene_variant 0.55 ethambutol
embA 4245813 c.2581_2583delCCCinsGG frameshift_variant&missense_variant 0.56 ethambutol Uncertain significance
embA 4245820 p.Ser863Thr missense_variant 0.56 ethambutol
embB 4245824 c.-690G>C upstream_gene_variant 0.56 ethambutol
embB 4245833 c.-681G>C upstream_gene_variant 0.55 ethambutol
embB 4245842 c.-672G>C upstream_gene_variant 0.55 ethambutol
embB 4245845 c.-669T>C upstream_gene_variant 0.55 ethambutol
embB 4245851 c.-663G>C upstream_gene_variant 0.56 ethambutol
embB 4245860 c.-654C>G upstream_gene_variant 0.52 ethambutol
embA 4245885 p.Asp885Thr missense_variant 0.28 ethambutol
embA 4245892 p.Ile887Thr missense_variant 0.25 ethambutol Uncertain significance
embA 4245899 c.2667C>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4245902 c.-612G>A upstream_gene_variant 0.25 ethambutol
embB 4245905 c.-609C>G upstream_gene_variant 0.25 ethambutol
embB 4245911 c.-603A>G upstream_gene_variant 0.23 ethambutol
embB 4245917 c.-597G>A upstream_gene_variant 0.24 ethambutol
embA 4245930 p.Gly900Arg missense_variant 0.27 ethambutol
embA 4246055 c.2823T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4246064 c.-450T>C upstream_gene_variant 0.31 ethambutol
embA 4246080 c.2848_2850delCCTinsTC frameshift_variant&missense_variant 0.32 ethambutol Uncertain significance
embA 4246088 c.2856A>G synonymous_variant 0.36 ethambutol Not assoc w R
embB 4246097 c.-417C>G upstream_gene_variant 0.4 ethambutol
embA 4246103 c.2871C>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
embB 4246109 c.-405C>G upstream_gene_variant 0.39 ethambutol
embB 4246115 c.-399T>G upstream_gene_variant 0.38 ethambutol
embA 4246128 c.2896_2898delTCTinsAC frameshift_variant&missense_variant 0.36 ethambutol Uncertain significance
embA 4246138 p.Arg969Gln missense_variant 0.34 ethambutol
embB 4246140 c.-374T>C upstream_gene_variant 0.36 ethambutol
embA 4246143 p.Ile971Val missense_variant 0.36 ethambutol
embA 4246151 c.2919A>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embA 4246152 p.Ala974Gln missense_variant 0.35 ethambutol
embB 4246157 c.-357A>G upstream_gene_variant 0.38 ethambutol
embA 4246164 c.2932T>C synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embB 4246184 c.-330A>C upstream_gene_variant 0.47 ethambutol
embB 4246196 c.-318C>G upstream_gene_variant 0.46 ethambutol
embB 4246205 c.-309A>G upstream_gene_variant 0.45 ethambutol
embB 4246211 c.-303T>C upstream_gene_variant 0.44 ethambutol
embB 4246217 c.-297G>A upstream_gene_variant 0.39 ethambutol
embA 4246220 c.2988T>C synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embB 4246223 c.-291C>T upstream_gene_variant 0.4 ethambutol
embA 4246227 p.Ile999Val missense_variant 0.44 ethambutol
embA 4246235 c.3003G>A synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embA 4246242 p.Gln1004Gly missense_variant 0.4 ethambutol
embB 4246250 c.-264G>C upstream_gene_variant 0.43 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.43 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.45 ethambutol
embA 4246264 p.His1011Arg missense_variant 0.49 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.53 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.51 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.52 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.5 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.52 ethambutol
embA 4246329 p.Thr1033Ala missense_variant 0.46 ethambutol
embB 4246349 c.-165C>G upstream_gene_variant 0.39 ethambutol
embA 4246359 c.3127_3129delGCCinsTG frameshift_variant&missense_variant 0.39 ethambutol Uncertain significance
embB 4246367 c.-147C>T upstream_gene_variant 0.4 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.4 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.36 ethambutol
embA 4246379 c.3147C>T synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embB 4246400 c.-114G>C upstream_gene_variant 0.29 ethambutol
embB 4247355 p.Ala281Val missense_variant 0.18 ethambutol Uncertain significance
embB 4247358 p.Val282Ala missense_variant 0.26 ethambutol Uncertain significance
embB 4247365 c.852A>C synonymous_variant 0.37 ethambutol
embB 4247371 c.858C>G synonymous_variant 0.42 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.43 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.47 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.48 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.52 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.55 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.57 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.58 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.58 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.58 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.57 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.57 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.62 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.63 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.68 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.7 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.71 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.66 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.64 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.64 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.62 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.62 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.62 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.62 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.61 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.57 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.56 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.48 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.47 ethambutol
embB 4247638 c.1125G>T synonymous_variant 0.42 ethambutol
embB 4247646 p.Glu378Ala missense_variant 0.31 ethambutol Not assoc w R
embB 4247656 c.1143A>G synonymous_variant 0.28 ethambutol
embB 4247659 c.1146C>G synonymous_variant 0.27 ethambutol
embB 4247662 c.1149C>G synonymous_variant 0.25 ethambutol
embB 4247683 c.1170C>G synonymous_variant 0.33 ethambutol
embB 4247692 c.1179C>G synonymous_variant 0.39 ethambutol
embB 4247716 c.1203C>T synonymous_variant 0.43 ethambutol
embB 4247722 c.1209G>C synonymous_variant 0.43 ethambutol
embB 4247725 c.1212G>C synonymous_variant 0.43 ethambutol
embB 4247729 p.Gly406Pro missense_variant 0.43 ethambutol
embB 4247746 c.1233C>T synonymous_variant 0.49 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.53 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.53 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.53 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.6 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.6 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.6 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.58 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.58 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.61 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.62 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.61 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.62 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.63 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.62 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.64 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.64 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.64 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.62 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.63 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.62 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.61 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.61 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.63 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.64 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.64 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.66 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.68 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.69 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.66 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.67 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.68 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.59 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.44 ethambutol Uncertain significance
embB 4248070 c.1557T>C synonymous_variant 0.68 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.68 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.67 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.66 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.62 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.62 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.63 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.61 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.6 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.6 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.6 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.61 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.64 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.52 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.51 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.52 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.46 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.43 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.4 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.34 ethambutol
embB 4248361 c.1848A>C synonymous_variant 0.31 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.32 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.32 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.35 ethambutol
embB 4248407 c.1894_1896delTTAinsGG frameshift_variant&missense_variant 0.32 ethambutol
embB 4248410 c.1897_1899delTTCinsCG frameshift_variant&missense_variant 0.29 ethambutol
embB 4248419 p.Leu636Met missense_variant 0.28 ethambutol
embB 4248425 c.1912T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4248430 c.1917T>C synonymous_variant 0.29 ethambutol
embB 4248432 p.Trp640Phe missense_variant 0.35 ethambutol
embB 4248457 c.1944T>C synonymous_variant 0.27 ethambutol
embB 4248472 c.1959T>C synonymous_variant 0.24 ethambutol
embB 4248475 c.1962G>C synonymous_variant 0.23 ethambutol
embB 4248488 c.1975_1977delGCGinsAC frameshift_variant&missense_variant 0.23 ethambutol
embB 4248504 p.Asp664Gly missense_variant 0.24 ethambutol Uncertain significance
embB 4248508 c.1995G>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4248512 c.1999_2001delACAinsTG frameshift_variant&stop_gained 0.24 ethambutol
embB 4249276 c.2763A>G synonymous_variant 0.23 ethambutol
embB 4249277 p.Tyr922Asn missense_variant 0.23 ethambutol
embB 4249282 c.2769A>C synonymous_variant 0.23 ethambutol
embB 4249291 c.2778C>A synonymous_variant 0.23 ethambutol
embB 4249312 c.2799C>T synonymous_variant 0.24 ethambutol
embB 4249321 c.2808A>C synonymous_variant 0.24 ethambutol
embB 4249322 p.Ala937Ser missense_variant 0.26 ethambutol
embB 4249325 c.2812_2814delAAGinsGC frameshift_variant&missense_variant 0.24 ethambutol
embB 4249333 c.2820C>G synonymous_variant 0.25 ethambutol
embB 4249336 c.2823C>G synonymous_variant 0.25 ethambutol
embB 4249339 c.2826T>C synonymous_variant 0.25 ethambutol
embB 4249342 c.2829C>G synonymous_variant 0.25 ethambutol
embB 4249348 c.2835G>C synonymous_variant 0.28 ethambutol
embB 4249351 c.2838C>G synonymous_variant 0.29 ethambutol
embB 4249369 c.2856T>C synonymous_variant 0.39 ethambutol
embB 4249375 c.2862G>C synonymous_variant 0.42 ethambutol
embB 4249381 c.2868A>G synonymous_variant 0.44 ethambutol
embB 4249384 c.2871G>T synonymous_variant 0.45 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.41 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.4 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.37 ethambutol
embB 4249429 c.2916C>T synonymous_variant 0.4 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.4 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.44 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.56 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.56 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.6 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.55 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.55 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.55 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.54 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.54 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.53 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.54 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.51 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.48 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.49 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.46 ethambutol
embB 4249594 c.3081G>C synonymous_variant 0.43 ethambutol
embB 4249606 c.3093C>A synonymous_variant 0.34 ethambutol
embB 4249609 c.3096T>C synonymous_variant 0.32 ethambutol
embB 4249615 c.3102C>G synonymous_variant 0.29 ethambutol
embB 4249618 c.3105C>G synonymous_variant 0.29 ethambutol
embB 4249624 c.3111C>G synonymous_variant 0.27 ethambutol
embB 4249627 c.3114G>C synonymous_variant 0.27 ethambutol
embB 4249640 c.3127T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
aftB 4267214 c.1623A>C synonymous_variant 0.2 ethambutol
aftB 4267241 c.1596G>C synonymous_variant 0.33 ethambutol
aftB 4267244 c.1593T>C synonymous_variant 0.33 ethambutol
aftB 4267256 c.1581C>G synonymous_variant 0.33 ethambutol
aftB 4267262 c.1575T>C synonymous_variant 0.34 ethambutol
aftB 4267266 p.Ala524Gly missense_variant 0.33 ethambutol
aftB 4267268 c.1569T>C synonymous_variant 0.33 ethambutol
aftB 4267274 c.1563G>C synonymous_variant 0.33 ethambutol
aftB 4267289 p.Ala516Gln missense_variant 0.32 ethambutol
aftB 4267292 c.1545C>G synonymous_variant 0.33 ethambutol
aftB 4267297 c.1540T>C synonymous_variant 0.32 ethambutol
aftB 4267301 c.1536C>T synonymous_variant 0.33 ethambutol
aftB 4267304 p.Val511Ala missense_variant 0.33 ethambutol
aftB 4267316 c.1521A>G synonymous_variant 0.35 ethambutol
aftB 4267325 c.1512G>C synonymous_variant 0.34 ethambutol
aftB 4267334 c.1503T>C synonymous_variant 0.35 ethambutol Not assoc w R - Interim
aftB 4267355 c.1480_1482delCTAinsGC frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
aftB 4267364 p.Met491Ile missense_variant 0.22 ethambutol Uncertain significance
aftB 4267647 p.Asp397Gly missense_variant 0.51 ethambutol Not assoc w R
aftB 4268081 c.756A>G synonymous_variant 0.33 ethambutol
aftB 4268084 c.753G>C synonymous_variant 0.33 ethambutol
aftB 4268096 c.741C>G synonymous_variant 0.39 ethambutol
aftB 4268099 c.738G>C synonymous_variant 0.38 ethambutol
aftB 4268102 c.735C>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
aftB 4268117 c.720G>C synonymous_variant 0.46 ethambutol
aftB 4268123 c.712_714delAGTinsGC frameshift_variant&synonymous_variant 0.46 ethambutol Uncertain significance
aftB 4268129 c.708T>G synonymous_variant 0.46 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.47 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.47 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.48 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.49 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.49 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.51 ethambutol Not assoc w R - Interim
aftB 4268182 p.Phe219Leu missense_variant 0.51 ethambutol
aftB 4268183 c.654A>T synonymous_variant 0.5 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 0.51 ethambutol
aftB 4268205 p.Val211Ala missense_variant 0.5 ethambutol
aftB 4268213 c.624T>G synonymous_variant 0.48 ethambutol
aftB 4268225 c.612G>C synonymous_variant 0.4 ethambutol
aftB 4268236 p.Leu201Met missense_variant 0.33 ethambutol
ubiA 4269075 c.757_759delATTinsGC frameshift_variant&missense_variant 0.23 ethambutol
aftB 4269159 c.-323G>C upstream_gene_variant 0.23 ethambutol
ubiA 4269164 p.Leu224Met missense_variant 0.23 ethambutol
aftB 4269165 c.-329G>C upstream_gene_variant 0.23 ethambutol
aftB 4269179 c.-343C>A upstream_gene_variant 0.25 ethambutol
aftB 4269183 c.-347T>C upstream_gene_variant 0.22 ethambutol
aftB 4269186 c.-350C>G upstream_gene_variant 0.24 ethambutol
aftB 4269342 c.-506G>C upstream_gene_variant 0.23 ethambutol
ubiA 4269357 p.Ile159Met missense_variant 0.21 ethambutol Uncertain significance
aftB 4269363 c.-527T>C upstream_gene_variant 0.2 ethambutol
aftB 4269372 c.-536G>A upstream_gene_variant 0.21 ethambutol
ethA 4326476 p.Leu333Pro missense_variant 0.44 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407620 p.Tyr195His missense_variant 0.46 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 0.6 streptomycin Not assoc w R