TB-Profiler result

Run: ERR4798493
Summary

Run ID: ERR4798493

Sample name:

Date: 2024-03-27T00:53:36.961994

Number of reads: 2868195

Percentage reads mapped: 72.24

Median coverage: 84.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.98
La1.2.BCG M.bovis None 0.07
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.98
lineage2.2 East-Asian (Beijing) RD105;RD207 0.95
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
p.His312Arg Mutation from literature
pyrazinamide
streptomycin rpsL p.Lys43Arg Assoc w R
rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide ethA c.-1080_576del Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.412_414delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1078_1080delTTGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491194 c.412_414delCTAinsTG frameshift_variant&stop_gained 0.2 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761155 p.Ser450Leu missense_variant 0.69 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.7 streptomycin Assoc w R
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.31 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304008 c.1078_1080delTTGinsCC frameshift_variant&missense_variant 0.28 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
embB 4247429 p.Met306Val missense_variant 0.78 ethambutol Assoc w R
embB 4247448 p.His312Arg missense_variant 0.22 ethambutol Mutation from literature
ethA 4326897 c.-1080_576del start_lost&conservative_inframe_deletion 0.99 ethionamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 600 c.600T>A synonymous_variant 0.18 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.22 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 649 c.649C>T synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.21 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.22 isoniazid
dnaA 669 c.669C>T synonymous_variant 0.23 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.21 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 708 c.708T>C synonymous_variant 0.17 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.2 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.19 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.2 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.2 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.21 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.22 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.21 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.26 isoniazid Uncertain significance
dnaA 813 c.813C>T synonymous_variant 0.24 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.22 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.19 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.19 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.19 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.19 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.22 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.22 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.23 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.23 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.25 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.26 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.28 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.24 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.24 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.25 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.25 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.26 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.27 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.24 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.24 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.24 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.27 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>G synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.26 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.27 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.25 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.29 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.28 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.27 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.24 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.23 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.3 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.35 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.36 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.36 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.39 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.43 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.44 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.4 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.41 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.41 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.4 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.42 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.35 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.31 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.32 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.33 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.3 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.3 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.27 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.28 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.33 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.29 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.25 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.23 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.25 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.25 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 1311 c.1311C>G synonymous_variant 0.27 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.25 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.26 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.26 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.37 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.34 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.36 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.35 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.33 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.33 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.31 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.29 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.3 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.29 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.31 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.31 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.28 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.29 isoniazid
dnaA 1461 c.1461C>G synonymous_variant 0.28 isoniazid
dnaA 1470 c.1470C>T synonymous_variant 0.27 isoniazid
dnaA 1485 c.1485A>G synonymous_variant 0.18 isoniazid
gyrB 6238 c.999G>A synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.4 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.19 levofloxacin Uncertain significance
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>T upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.35 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6838 c.-464C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642_1644delTTGinsCC frameshift_variant&missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin
gyrA 6889 c.-413G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6898 c.-404G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 7100 c.1861T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7108 c.-194G>A upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 7124 p.Ser629Thr missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7216 c.1977G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7631 c.330G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCC frameshift_variant&missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7725 c.424C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 7739 c.438C>T synonymous_variant 0.31 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7763 c.462T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8168 c.867A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.31 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8357 c.1056G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8367 c.1066C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8400 c.1099_1101delGACinsAT frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8708 c.1407G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9122 c.1821C>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.18 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9179 c.1878C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9191 c.1890G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9224 c.1923C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 p.Asp669Glu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9344 c.2043C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 490803 c.21T>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490869 c.87C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490935 c.153C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491001 c.219G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491067 c.285C>T synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fgd1 491077 p.Asn99Gly missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491083 p.Val101Ile missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491130 c.348C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>A synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491607 c.825G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491613 c.831C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575695 c.348C>G synonymous_variant 0.18 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.21 ethionamide
isoniazid
mshA 575704 c.357T>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.19 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.2 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575755 c.408G>A synonymous_variant 0.21 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.21 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.21 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.2 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.21 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575875 c.528C>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.18 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.82 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 619507 c.-384A>G upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619528 c.-363C>G upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356_-354delCAAinsGCG upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619543 c.-348C>G upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619561 c.-330G>C upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>C upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620284 c.394_396delGCGinsCC frameshift_variant&missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>T synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620298 c.408G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.2 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620424 c.534G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620436 c.546T>A synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620461 p.Val191Ile missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620553 c.663T>C synonymous_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620659 c.769_771delCGCinsAG frameshift_variant&missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620664 c.774C>T synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAA frameshift_variant&missense_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620763 c.873G>A synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620769 c.879C>G synonymous_variant 0.24 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620790 c.900C>T synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620796 c.906C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
Rv0565c 656219 p.His418Tyr missense_variant 0.17 ethionamide
Rv0565c 656226 c.1243_1245delGCCinsTT frameshift_variant&missense_variant 0.16 ethionamide Uncertain significance
Rv0565c 656243 p.Leu410Met missense_variant 0.16 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.19 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.18 ethionamide
Rv0565c 656304 c.1167T>C synonymous_variant 0.18 ethionamide
Rv0565c 656924 p.Ile183Val missense_variant 0.16 ethionamide
Rv0565c 657027 c.444T>C synonymous_variant 0.19 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 0.91 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.9 ethionamide Uncertain significance
Rv0565c 657259 p.Tyr71Phe missense_variant 0.19 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.18 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.18 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.18 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.21 ethionamide
Rv0565c 657303 c.168C>T synonymous_variant 0.22 ethionamide Not assoc w R - Interim
Rv0565c 657318 c.153T>C synonymous_variant 0.21 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.2 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.2 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.2 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.2 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.19 ethionamide
Rv0565c 657348 c.123A>G synonymous_variant 0.19 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.19 ethionamide
Rv0565c 657690 c.-220C>A upstream_gene_variant 0.17 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.17 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.22 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.26 isoniazid
hadA 731687 c.-243_-242insCACAGATCTTTT upstream_gene_variant 0.28 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.28 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.28 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.32 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.32 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.32 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.33 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.3 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.29 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.19 isoniazid
hadA 732253 c.324T>C synonymous_variant 0.2 isoniazid
hadA 732259 c.330T>C synonymous_variant 0.21 isoniazid
hadA 732268 c.339T>G synonymous_variant 0.2 isoniazid
hadA 732270 p.Glu114Val missense_variant 0.2 isoniazid
hadA 732272 p.Ala115Ser missense_variant 0.2 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.25 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.25 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.25 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.27 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.26 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.27 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.24 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.27 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.27 isoniazid
nusG 734176 c.-78G>T upstream_gene_variant 0.14 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.24 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.25 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.28 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.3 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.31 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.32 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.34 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.25 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.24 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.21 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.21 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.2 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.2 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.18 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.17 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.29 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.37 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.39 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.37 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.43 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.43 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.43 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.43 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.39 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.36 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.36 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.34 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.3 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.25 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.23 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.24 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.28 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.27 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.22 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.22 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.2 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.2 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760949 c.1143C>T synonymous_variant 0.22 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.3 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.29 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.31 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.3 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.27 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.27 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.29 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.28 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.25 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.26 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.25 rifampicin
rpoB 761373 p.Val523His missense_variant 0.24 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.25 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.25 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.25 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.25 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.25 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.26 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.26 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.26 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.26 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.27 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.23 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.21 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.23 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.19 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761639 c.1833G>A synonymous_variant 0.16 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.2 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.2 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.24 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.23 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.24 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.21 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.27 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.27 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.25 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.27 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.26 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.29 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.4 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.33 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.33 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.33 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.33 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.33 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.38 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.3 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.28 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.26 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.27 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.37 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.31 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.29 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.29 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.28 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.27 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.27 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.27 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.24 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.25 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.21 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.22 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.25 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.25 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.25 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.23 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762490 p.Val895Asp missense_variant 0.16 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.16 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.17 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.17 rifampicin
rpoC 762758 c.-612G>C upstream_gene_variant 0.2 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.24 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.23 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.25 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.27 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.24 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.25 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.36 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.4 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.59 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.33 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.33 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.29 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.3 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.3 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.31 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.27 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.23 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.23 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.18 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.32 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.36 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.36 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.32 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.3 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.29 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.25 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.26 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.28 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.27 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.25 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.25 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.21 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.21 rifampicin
rpoC 763877 c.508_510delCTAinsTG frameshift_variant&stop_gained 0.21 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.21 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.21 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.22 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.23 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.23 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763993 p.Ile208Met missense_variant 0.18 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.18 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.18 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.21 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.22 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.24 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.23 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.25 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.24 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.36 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.3 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.29 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.31 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.32 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.34 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.27 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.3 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.32 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.33 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.45 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.26 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.28 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.21 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.23 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.24 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.25 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.25 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.36 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.41 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.41 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.33 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.33 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.41 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764817 p.Val483Ala missense_variant 0.62 rifampicin Uncertain significance
rpoC 764827 c.1458G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.27 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.28 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.29 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.29 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.23 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.19 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.18 rifampicin
rpoC 765292 c.1923G>C synonymous_variant 0.17 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.2 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.23 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.29 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.33 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.27 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.3 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.37 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.39 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.36 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.36 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.36 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.36 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.38 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.39 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.42 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.37 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.34 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.34 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.32 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.33 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.33 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.33 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.33 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.4 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.36 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.42 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.39 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.38 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.37 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.36 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.41 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.41 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.38 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.3 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.27 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.23 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766280 p.Ser971Gly missense_variant 0.18 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.21 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.27 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.25 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.27 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.3 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.3 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.33 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.33 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.31 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.3 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.28 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.25 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.23 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.21 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.21 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.22 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.21 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.2 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.19 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.21 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.21 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.23 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.2 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.18 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.19 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.19 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.23 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.3 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.34 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.36 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.37 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.36 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.38 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.36 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.35 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.42 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.4 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.46 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.32 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.32 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.34 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.3 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.31 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.36 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.32 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.24 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.18 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.18 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.23 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.25 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.31 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.3 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.31 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.3 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.29 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.34 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.35 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.39 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.39 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.4 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.36 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.37 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.37 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.36 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.35 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.34 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.31 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.3 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.3 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.29 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.29 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.27 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.25 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.23 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.17 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.3 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.3 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.3 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.33 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.35 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.41 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.39 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.38 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.4 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.37 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.32 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.32 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.31 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.31 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.29 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.27 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.21 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.21 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.21 linezolid
rplC 800814 c.6A>G synonymous_variant 0.21 linezolid
rplC 800817 c.9A>T synonymous_variant 0.22 linezolid
rplC 800844 c.36T>C synonymous_variant 0.22 linezolid
rplC 800865 c.57A>G synonymous_variant 0.19 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.19 linezolid
rplC 800874 c.66A>G synonymous_variant 0.19 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.19 linezolid
rplC 800880 c.72A>G synonymous_variant 0.2 linezolid
rplC 800889 c.81C>G synonymous_variant 0.2 linezolid
rplC 800892 c.84G>C synonymous_variant 0.19 linezolid
rplC 800907 c.99C>G synonymous_variant 0.19 linezolid
rplC 801246 c.438C>T synonymous_variant 0.17 linezolid
rplC 801249 c.441T>C synonymous_variant 0.18 linezolid
rplC 801255 c.447C>T synonymous_variant 0.18 linezolid
rplC 801264 c.456C>T synonymous_variant 0.17 linezolid
rplC 801267 c.459A>T synonymous_variant 0.17 linezolid
rplC 801285 c.477G>C synonymous_variant 0.19 linezolid
rplC 801300 c.492C>G synonymous_variant 0.22 linezolid
rplC 801309 c.501C>G synonymous_variant 0.24 linezolid
rplC 801312 c.504G>C synonymous_variant 0.24 linezolid
rplC 801321 c.513C>T synonymous_variant 0.26 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.25 linezolid
rplC 801339 c.531T>C synonymous_variant 0.24 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.24 linezolid
rplC 801348 c.540T>G synonymous_variant 0.23 linezolid
rplC 801357 c.549T>C synonymous_variant 0.22 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.23 linezolid
rplC 801402 c.594T>C synonymous_variant 0.21 linezolid
rplC 801405 c.597T>C synonymous_variant 0.21 linezolid
rplC 801423 c.615G>C synonymous_variant 0.24 linezolid
rplC 801426 c.618C>G synonymous_variant 0.24 linezolid
rplC 801427 p.Met207Val missense_variant 0.25 linezolid
rplC 801438 c.630T>C synonymous_variant 0.26 linezolid
rplC 801442 p.Ile212Val missense_variant 0.26 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303480 p.Gln184Glu missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303489 c.559C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303501 c.571C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303521 c.591C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303530 c.600G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303827 c.897A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303866 p.Glu312Asp missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303977 c.1047C>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304085 c.1155C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304091 p.Asp387Glu missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304106 c.1176G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304132 p.Ala401Gly missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304161 p.Arg411Trp missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304174 p.Val415Ala missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304187 c.1257T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304208 c.1278C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.34 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305279 p.His783Gln missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305331 p.Glu801Lys missense_variant 0.16 clofazimine
pretomanid
delamanid
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1461132 p.Val30Ile missense_variant 0.21 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.23 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.23 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.22 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.23 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.22 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.23 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.25 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.27 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.23 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.21 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
inhA 1673568 c.-634C>G upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673580 c.-622T>G upstream_gene_variant 0.2 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>G upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673591 c.-611C>T upstream_gene_variant 0.18 ethionamide
isoniazid Uncertain significance
fabG1 1673615 p.Glu59Val missense_variant 0.16 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.16 ethionamide
isoniazid
fabG1 1673890 p.Ala151Ser missense_variant 0.16 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.23 ethionamide
isoniazid
inhA 1674015 c.-187C>T upstream_gene_variant 0.18 ethionamide
isoniazid Uncertain significance
inhA 1674018 c.-184G>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1674021 c.-181G>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1674042 c.-160G>T upstream_gene_variant 0.18 ethionamide
isoniazid
fabG1 1674049 c.610_612delCAAinsGC frameshift_variant&missense_variant 0.17 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.18 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.18 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.17 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.28 ethionamide
isoniazid
inhA 1674594 c.393C>T synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.25 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674741 c.540C>T synonymous_variant 0.24 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674746 p.Tyr182Phe missense_variant 0.25 ethionamide
isoniazid
inhA 1674750 c.549T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674753 c.552G>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.27 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674816 c.615T>C synonymous_variant 0.25 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674822 c.621C>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674828 c.627G>A synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.19 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.19 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.24 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.3 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.32 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.25 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.28 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.27 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.33 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.29 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.25 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.2 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.2 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.27 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.24 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.27 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.27 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.18 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.18 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064942 c.-214G>A upstream_gene_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101894 c.1149T>G synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2101912 c.1131G>C synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101920 c.1123A>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101924 c.1119T>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101939 c.1104A>G synonymous_variant 0.2 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.23 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.18 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.16 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.21 isoniazid
kasA 2518474 c.360G>A synonymous_variant 0.21 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.21 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.22 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.22 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.22 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.28 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.3 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.31 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.26 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.21 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.2 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.2 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.2 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.2 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.19 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.22 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.21 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.18 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.19 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.19 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.2 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.19 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.19 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.2 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.22 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.23 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.24 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.25 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.26 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.26 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.24 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.22 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.24 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.25 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.25 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.25 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.24 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.23 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.24 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.2 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.2 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.19 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.18 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.2 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.21 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.21 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.22 isoniazid
kasA 2518951 c.837G>C synonymous_variant 0.2 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.21 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.23 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.2 isoniazid
kasA 2518975 c.861C>G synonymous_variant 0.2 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.18 isoniazid
kasA 2519056 c.942G>C synonymous_variant 0.18 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.17 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.2 isoniazid
kasA 2519095 c.981C>A synonymous_variant 0.17 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.16 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.17 isoniazid
ahpC 2726303 c.111T>C synonymous_variant 0.18 isoniazid
ahpC 2726540 c.348C>G synonymous_variant 0.19 isoniazid
ahpC 2726543 c.351A>G synonymous_variant 0.2 isoniazid
ahpC 2726546 c.354C>G synonymous_variant 0.2 isoniazid
ahpC 2726551 p.Gln120Leu missense_variant 0.17 isoniazid
ahpC 2726564 c.372C>G synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ahpC 2726579 c.387T>C synonymous_variant 0.2 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.2 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.2 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.2 isoniazid
ahpC 2726601 p.Ile137Leu missense_variant 0.2 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.16 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.18 isoniazid
Rv2477c 2782450 c.1593C>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782513 c.1530G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782522 c.1521G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782848 c.1195C>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.35 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.3 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 c.544_546delTTGinsCC frameshift_variant&missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783502 c.541T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783521 c.522G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783662 c.381G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3064860 c.1332G>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064863 c.1329G>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064872 c.1320T>G synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064877 p.Ser439Ala missense_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064887 c.1305A>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065517 c.675C>G synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065523 c.669C>T synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065532 c.660A>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065915 c.277C>T synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065946