TB-Profiler result

Run: SRR1175127
Summary

Run ID: SRR1175127

Sample name:

Date: 2024-04-16T00:46:22.648636

Number of reads: 1295682

Percentage reads mapped: 61.53

Median coverage: 29.0

Strain: lineage2.2.1.2

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.98
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.94
lineage2.2 East-Asian (Beijing) RD105;RD207 0.98
lineage2.2.1.2 East-Asian (Beijing) RD105;RD207;RD181;RD142 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.658_660delCGAinsAG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303588 c.658_660delCGAinsAG frameshift_variant&synonymous_variant 0.28 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.2 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.19 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.18 isoniazid
gyrB 6115 c.876A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6123 p.Ala295Gly missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6170 p.His311Ala missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7376 c.75G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7382 c.81C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7394 c.93T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7418 c.117C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7436 c.135C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7442 c.141G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7484 c.183T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7506 p.Ser69Gly missense_variant 0.39 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7526 c.225G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>A synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7562 c.261C>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7569 p.Ala90Ser missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7775 c.474C>T synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7871 c.570G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7883 c.582G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7884 c.583_585delCGTinsGC frameshift_variant&missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 7928 p.Asp209Glu missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8273 c.972C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.38 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8366 c.1065G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8378 c.1077C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 8414 c.1113C>T synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8417 c.1116C>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8672 c.1371A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8705 c.1404C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8711 c.1410A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8720 c.1419G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8726 c.1425G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9242 c.1941A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9266 p.Asp655Glu missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491307 c.525C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491316 c.534C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575704 c.357T>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575714 p.Tyr123Asn missense_variant 0.39 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.41 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.43 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.42 ethionamide
isoniazid
mshA 575740 c.393G>C synonymous_variant 0.44 ethionamide
isoniazid
mshA 575772 p.Val142Ala missense_variant 0.52 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.55 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.52 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.53 ethionamide
isoniazid Not assoc w R - Interim
mshA 575821 c.474G>C synonymous_variant 0.44 ethionamide
isoniazid
mshA 575840 c.494dupC frameshift_variant 0.37 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575844 c.498delC frameshift_variant 0.37 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575864 c.517T>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575885 c.538C>T synonymous_variant 0.3 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.65 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575916 p.Asp190Ala missense_variant 0.3 ethionamide
isoniazid
mshA 575920 c.573C>T synonymous_variant 0.33 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ccsA 620388 c.498A>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620409 c.519C>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.19 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620418 c.528G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620431 p.Leu181Ile missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620436 c.546T>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 656085 c.1386A>G synonymous_variant 0.28 ethionamide
Rv0565c 656088 c.1383A>G synonymous_variant 0.28 ethionamide
Rv0565c 656091 c.1380T>C synonymous_variant 0.28 ethionamide
Rv0565c 656097 c.1374G>C synonymous_variant 0.3 ethionamide
Rv0565c 656129 p.Tyr448His missense_variant 0.23 ethionamide
Rv0565c 656131 p.Pro447Leu missense_variant 0.24 ethionamide
Rv0565c 656133 c.1338G>A synonymous_variant 0.24 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 0.97 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
hadA 731723 c.-207T>C upstream_gene_variant 0.15 isoniazid
hadA 731729 c.-201C>T upstream_gene_variant 0.21 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.29 isoniazid
hadA 731753 c.-177A>C upstream_gene_variant 0.29 isoniazid
hadA 731756 c.-174C>T upstream_gene_variant 0.31 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.32 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.32 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 0.31 isoniazid
hadA 731825 c.-105G>C upstream_gene_variant 0.21 isoniazid
nusG 734439 c.186C>G synonymous_variant 0.24 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.28 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.28 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.26 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.26 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734505 c.252G>C synonymous_variant 0.38 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.31 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734596 c.343T>C synonymous_variant 0.29 rifampicin
nusG 734832 c.579C>G synonymous_variant 0.5 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.48 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.52 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.52 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.52 rifampicin
nusG 734862 c.609C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
nusG 734863 p.Thr204Ser missense_variant 0.52 rifampicin
nusG 734889 c.636G>A synonymous_variant 0.57 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.56 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.5 rifampicin
nusG 734928 c.675A>G synonymous_variant 0.36 rifampicin
nusG 734931 c.678A>G synonymous_variant 0.3 rifampicin
nusG 734934 c.681G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734940 c.687G>A synonymous_variant 0.25 rifampicin
nusG 734950 p.Gly233Asn missense_variant 0.23 rifampicin
nusG 734955 c.702A>G synonymous_variant 0.22 rifampicin
rpoB 760139 c.333A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.22 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.21 rifampicin
rpoB 760155 p.Lys117Arg missense_variant 0.19 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.28 rifampicin
rpoB 760178 c.372G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>G synonymous_variant 0.3 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.35 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.22 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.18 rifampicin
rpoB 760354 p.Glu183Ala missense_variant 0.16 rifampicin
rpoB 760357 p.Thr184Ser missense_variant 0.17 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.18 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760490 c.684C>T synonymous_variant 0.3 rifampicin Not assoc w R
rpoB 760532 c.726T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Arg missense_variant 0.2 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.23 rifampicin Uncertain significance
rpoB 760587 p.Thr261Ala missense_variant 0.24 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.29 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.31 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760697 p.Glu297Asp missense_variant 0.25 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.28 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.31 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.32 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.28 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.41 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.5 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.53 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.53 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.51 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761177 c.1371G>A synonymous_variant 0.51 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761201 c.1395G>A synonymous_variant 0.49 rifampicin
rpoB 761204 c.1398C>T synonymous_variant 0.5 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.51 rifampicin
rpoB 761222 c.1416G>T synonymous_variant 0.45 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.45 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.33 rifampicin
rpoB 761357 c.1551G>C synonymous_variant 0.33 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761373 p.Val523His missense_variant 0.34 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.42 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.46 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.47 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762006 c.2200_2202delCGCinsAG frameshift_variant&missense_variant 0.44 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Thr missense_variant 0.4 rifampicin Uncertain significance
rpoB 762029 c.2223C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.28 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.32 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.32 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.32 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.37 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.41 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>T synonymous_variant 0.52 rifampicin
rpoB 762212 c.2406G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.45 rifampicin
rpoB 762266 c.2460T>G synonymous_variant 0.39 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.34 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.36 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.32 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.32 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.3 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.27 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.24 rifampicin
rpoC 762407 c.-963G>C upstream_gene_variant 0.23 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762799 p.Ala998Gly missense_variant 0.27 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762818 c.3012C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.54 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.41 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.41 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.42 rifampicin
rpoB 763094 c.3288G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.36 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.32 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.28 rifampicin
rpoB 763203 p.Ser1133Ala missense_variant 0.28 rifampicin Uncertain significance
rpoB 763207 p.Ser1134Lys missense_variant 0.28 rifampicin Uncertain significance
rpoB 763214 c.3408T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763227 c.3421C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763396 c.27A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763430 c.61A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763447 c.78C>T synonymous_variant 0.38 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.4 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.33 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764085 p.Asn239Thr missense_variant 0.17 rifampicin Uncertain significance
rpoC 764087 p.Leu240Val missense_variant 0.19 rifampicin Uncertain significance
rpoC 764152 c.783C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.22 rifampicin
rpoC 764254 c.885G>C synonymous_variant 0.31 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.32 rifampicin
rpoC 764266 c.897T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764272 c.903G>C synonymous_variant 0.27 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764279 p.Gln304Met missense_variant 0.24 rifampicin
rpoC 764284 c.915G>C synonymous_variant 0.26 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.32 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.31 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.33 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>A synonymous_variant 0.4 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>A synonymous_variant 0.42 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.4 rifampicin
rpoC 764806 c.1437G>A synonymous_variant 0.41 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.37 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>G synonymous_variant 0.28 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.28 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.21 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.18 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.24 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.34 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765079 c.1710T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.38 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.38 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765339 p.Gln657Arg missense_variant 0.36 rifampicin Uncertain significance
rpoC 765349 c.1980T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765404 p.Leu679Thr missense_variant 0.45 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765445 c.2076G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765453 p.Ala695Val missense_variant 0.46 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765547 c.2178C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2180delAGinsTC synonymous_variant 0.27 rifampicin
rpoC 765553 c.2184C>G synonymous_variant 0.27 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.27 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.29 rifampicin
rpoC 765577 c.2208G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765592 c.2223C>T synonymous_variant 0.42 rifampicin
rpoC 765607 c.2238C>G synonymous_variant 0.41 rifampicin
rpoC 765611 p.His748Ser missense_variant 0.39 rifampicin Uncertain significance
rpoC 765628 c.2259G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765662 c.2293_2295delTTGinsCC frameshift_variant&missense_variant 0.42 rifampicin
rpoC 765673 p.Asp768Glu missense_variant 0.41 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765787 c.2418C>T synonymous_variant 0.26 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.24 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.23 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.51 rifampicin Uncertain significance
rpoC 765899 c.2530C>T synonymous_variant 0.5 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765991 c.2622C>A synonymous_variant 0.33 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766294 c.2925C>T synonymous_variant 0.23 rifampicin
rpoC 766297 c.2928G>C synonymous_variant 0.25 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.3 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.34 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.51 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.56 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.56 rifampicin
rpoC 766375 c.3006C>G synonymous_variant 0.56 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.6 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.59 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.54 rifampicin
rpoC 766453 c.3084G>T synonymous_variant 0.49 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.49 rifampicin
rpoC 766469 c.3100C>T synonymous_variant 0.49 rifampicin
rpoC 766480 c.3111C>G synonymous_variant 0.39 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.36 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.36 rifampicin
rpoC 766517 p.Thr1050Ala missense_variant 0.27 rifampicin
rpoC 766547 p.Arg1060Lys missense_variant 0.27 rifampicin
rpoC 766564 c.3195C>G synonymous_variant 0.37 rifampicin
rpoC 766570 c.3201T>G synonymous_variant 0.41 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.42 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.44 rifampicin
rpoC 766610 p.Ser1081Pro missense_variant 0.44 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.41 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.33 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.26 rifampicin
rpoC 766654 c.3285C>G synonymous_variant 0.23 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.23 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.25 rifampicin
rpoC 766669 c.3300C>G synonymous_variant 0.27 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.29 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.32 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.4 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.39 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.5 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.5 rifampicin
rpoC 766732 c.3363G>A synonymous_variant 0.52 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.55 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.42 rifampicin
rpoC 766775 p.Arg1136Asn missense_variant 0.42 rifampicin
rpoC 766787 p.Glu1140Gln missense_variant 0.5 rifampicin Uncertain significance
rpoC 766798 c.3429C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.31 rifampicin
rpoC 767059 c.3690T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.31 rifampicin
rpoC 767110 c.3741T>C synonymous_variant 0.32 rifampicin
rpoC 767113 c.3744G>C synonymous_variant 0.31 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767152 c.3783T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767191 c.3822C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775946 c.2535C>G synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 0.97 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 0.95 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.28 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.27 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.3 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.31 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.33 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>G synonymous_variant 0.33 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.25 streptomycin
rpsL 781772 c.213C>G synonymous_variant 0.31 streptomycin
rpsL 781800 c.241C>T synonymous_variant 0.26 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.3 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.34 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.42 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.38 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.32 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.31 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.31 streptomycin
rpsL 781884 p.Asn109Gly missense_variant 0.22 streptomycin
rpsL 781889 c.330C>T synonymous_variant 0.23 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.23 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.23 streptomycin
rplC 800516 c.-293G>C upstream_gene_variant 0.25 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.31 linezolid
rplC 800558 c.-251G>A upstream_gene_variant 0.34 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.34 linezolid
rplC 800574 c.-235_-233delGTCinsACT upstream_gene_variant 0.32 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.36 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.3 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.29 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.33 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.32 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.33 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.32 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.33 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.27 linezolid
rplC 800699 c.-110G>A upstream_gene_variant 0.26 linezolid
rplC 800700 c.-109C>A upstream_gene_variant 0.26 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.26 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.27 linezolid
rplC 800744 c.-65G>T upstream_gene_variant 0.18 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.16 linezolid
rplC 800916 c.108A>G synonymous_variant 0.27 linezolid
rplC 800928 c.120C>T synonymous_variant 0.35 linezolid
rplC 800931 c.123G>C synonymous_variant 0.34 linezolid
rplC 800937 c.129A>G synonymous_variant 0.38 linezolid
rplC 800946 c.138T>C synonymous_variant 0.36 linezolid
rplC 800950 c.142_143delAGinsTC synonymous_variant 0.36 linezolid
rplC 800964 c.156G>C synonymous_variant 0.41 linezolid
rplC 800967 c.159C>T synonymous_variant 0.42 linezolid
rplC 800970 c.162T>C synonymous_variant 0.39 linezolid Not assoc w R - Interim
rplC 800985 c.177A>T synonymous_variant 0.34 linezolid
rplC 801009 c.201A>C synonymous_variant 0.23 linezolid
rplC 801210 c.402T>C synonymous_variant 0.43 linezolid
rplC 801220 p.Ser138Gly missense_variant 0.43 linezolid
rplC 801228 c.420T>C synonymous_variant 0.38 linezolid
rplC 801237 c.429G>A synonymous_variant 0.41 linezolid
rplC 801249 c.441T>G synonymous_variant 0.42 linezolid
rplC 801255 c.447C>T synonymous_variant 0.42 linezolid
rplC 801258 c.450C>G synonymous_variant 0.42 linezolid
rplC 801267 c.459A>T synonymous_variant 0.4 linezolid
rplC 801270 c.462T>C synonymous_variant 0.4 linezolid
rplC 801271 c.463_465delGCCinsTG frameshift_variant&missense_variant 0.38 linezolid
rplC 801276 c.468G>C synonymous_variant 0.38 linezolid
rplC 801281 p.Ala158Gly missense_variant 0.4 linezolid
rplC 801307 c.499_501delGCCinsTA frameshift_variant&missense_variant 0.28 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303581 c.651G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303583 p.Thr218Ser missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305360 c.2430G>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1305361 c.2431C>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1305381 c.2451G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471936 n.91A>G non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471996 n.151C>T non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>C non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838_839insTA non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_175delGGTGCinsCCGGTG non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1474089 n.432C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474105 n.448delTinsCG non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474108 n.451C>G non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474110 n.453A>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474116 n.459G>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474127 n.470G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474139 n.482C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474452 n.795C>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053delTinsGTGAG non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475037 n.1380T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475297 n.1640C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476108 n.2451T>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1476262 n.2605G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.63 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.68 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476692 n.3035T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
inhA 1674789 c.588G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674830 p.Glu210Gly missense_variant 0.23 ethionamide
isoniazid
inhA 1674848 p.Gln216Arg missense_variant 0.31 ethionamide
isoniazid Uncertain significance
inhA 1674870 c.669T>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674883 p.Ile228Val missense_variant 0.21 ethionamide Uncertain significance
isoniazid Uncertain significance
rpsA 1833589 c.48A>C synonymous_variant 0.25 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.25 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.25 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.26 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.26 pyrazinamide
rpsA 1833658 c.117C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1833661 c.120A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.26 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.31 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.36 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.37 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.37 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.34 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833814 c.273C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.28 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.42 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.41 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.35 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.46 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.36 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834040 p.Lys167Arg missense_variant 0.44 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.53 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.38 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.33 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1834423 c.882G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.45 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834522 c.981C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834527 p.Arg329Gln missense_variant 0.39 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.52 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.5 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.41 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834650 p.Thr370Asn missense_variant 0.4 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.28 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2170235 c.378T>C synonymous_variant 0.92 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.26 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.27 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.3 isoniazid
kasA 2518532 c.418C>T synonymous_variant 0.29 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.28 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.29 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.28 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.32 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.33 isoniazid
kasA 2518586 c.472_474delCTTinsGC frameshift_variant&missense_variant 0.26 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.27 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.25 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.25 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.39 isoniazid
kasA 2518787 p.Arg225Lys missense_variant 0.39 isoniazid
kasA 2518792 c.678C>T synonymous_variant 0.43 isoniazid
kasA 2518795 c.681C>A synonymous_variant 0.41 isoniazid
kasA 2518810 c.696G>A synonymous_variant 0.47 isoniazid
kasA 2518813 c.699C>T synonymous_variant 0.44 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.44 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.46 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.47 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.33 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.28 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.25 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.15 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.17 isoniazid
ahpC 2726648 c.456T>G synonymous_variant 0.19 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
ahpC 2726669 c.477T>C synonymous_variant 0.25 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.24 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ahpC 2726684 c.492G>C synonymous_variant 0.21 isoniazid
ahpC 2726693 c.501C>T synonymous_variant 0.21 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.21 isoniazid
Rv2477c 2783299 c.744A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783386 c.657G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783737 c.306C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783743 c.300C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065886 c.306C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065900 p.Pro98Ala missense_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065901 c.291A>G synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065907 c.285G>A synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065916 c.276T>C synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065922 c.270T>C synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065925 c.267G>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065946 p.Gly82Ala missense_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065952 c.240C>G synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065957 c.235T>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065972 p.Ile74Val missense_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066071 c.121T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066074 c.118C>T synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066081 c.111G>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066093 c.99T>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066096 c.96G>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066108 c.84C>T synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067742 c.204A>G synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067763 c.183C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067770 p.Gly59Ala missense_variant 0.37 para-aminosalicylic_acid
thyX 3067787 p.Lys53Arg missense_variant 0.37 para-aminosalicylic_acid
thyX 3067790 c.156C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.42 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624389 c.522C>G synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624396 p.Ala172Val missense_variant 0.3 bedaquiline
rifampicin
lpqB 3624401 c.510C>T synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624637 p.His92Asn missense_variant 0.29 bedaquiline
rifampicin
lpqB 3624646 c.265T>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624653 c.258C>T synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624676 p.Asn79Asp missense_variant 0.27 bedaquiline
rifampicin
lpqB 3624677 c.234C>G synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.27 bedaquiline
rifampicin Uncertain significance
lpqB 3624695 c.216C>T synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3624701 c.210T>G synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3624704 c.207G>A synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3624710 p.Leu67Arg missense_variant 0.29 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625729 c.885A>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3625744 c.870G>A synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.35 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625795 c.-885G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625801 c.-891G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3625804 c.808_810delAGGinsCC frameshift_variant&missense_variant 0.35 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625819 c.795G>A synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625822 c.-912C>T upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625828 c.-918G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625849 c.-939T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626711 c.-98T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3626729 c.619_621delAAGinsCA frameshift_variant&missense_variant 0.29 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626735 c.-122C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626750 c.-137T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626776 c.-163A>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626789 c.561C>T synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626816 c.-203G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626822 p.Asp176Glu missense_variant 0.18 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626995 c.-382C>A upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3626999 c.-386G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3627017 c.-404G>A upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627119 c.231T>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627131 p.Ala73Lys missense_variant 0.23 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3627152 c.-539C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.3 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
rpoA 3877695 c.813C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.19 rifampicin
rpoA 3877707 c.801G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.26 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>A synonymous_variant 0.29 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877788 c.720G>A synonymous_variant 0.32 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877821 c.687C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.38 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.39 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.37 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.31 rifampicin
rpoA 3877905 c.603A>C synonymous_variant 0.31 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.27 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877968 c.540C>G synonymous_variant 0.19 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.19 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.2 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878143 p.Gly122Asp missense_variant 0.21 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.24 rifampicin
rpoA 3878166 c.342C>G synonymous_variant 0.22 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.22 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878262 c.244_246delAGCinsGT frameshift_variant&synonymous_variant 0.37 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.39 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.39 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.46 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.56 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.56 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3878394 c.114G>T synonymous_variant 0.54 rifampicin
rpoA 3878400 c.108T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878403 c.105C>G synonymous_variant 0.52 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.46 rifampicin
rpoA 3878421 c.87A>T synonymous_variant 0.36 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.29 rifampicin
rpoA 3878689 c.-182G>A upstream_gene_variant 0.38 rifampicin
rpoA 3878694 c.-187A>G upstream_gene_variant 0.35 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.36 rifampicin
rpoA 3878701 c.-194C>T upstream_gene_variant 0.38 rifampicin
rpoA 3878722 c.-215C>G upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878725 c.-218A>G upstream_gene_variant 0.39 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.55 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.5 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.55 rifampicin Uncertain significance
rpoA 3878758 c.-251G>C upstream_gene_variant 0.48 rifampicin
rpoA 3878775 c.-268A>G upstream_gene_variant 0.5 rifampicin Uncertain significance
rpoA 3878779 c.-272C>T upstream_gene_variant 0.47 rifampicin Uncertain significance
rpoA 3878785 c.-278T>C upstream_gene_variant 0.42 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.44 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.55 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.5 rifampicin
rpoA 3878830 c.-325_-323delCTGinsAC upstream_gene_variant 0.41 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.38 rifampicin
rpoA 3878843 c.-337_-336delCGinsAA upstream_gene_variant 0.38 rifampicin
rpoA 3878845 c.-338G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.37 rifampicin
rpoA 3878873 c.-366G>A upstream_gene_variant 0.32 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.31 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.29 rifampicin
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.21 rifampicin
rpoA 3878899 c.-392C>G upstream_gene_variant 0.19 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.22 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.23 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.22 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879097 c.-590C>G upstream_gene_variant 0.26 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.36 rifampicin
rpoA 3879125 c.-618T>G upstream_gene_variant 0.35 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.36 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.37 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.38 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.33 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.33 delamanid
pretomanid
ddn 3986661 c.-183_-179delCAGAGinsT upstream_gene_variant 0.26 delamanid
pretomanid
ddn 3986673 c.-171C>T upstream_gene_variant 0.27 delamanid
pretomanid
ddn 3986696 c.-148G>C upstream_gene_variant 0.28 delamanid
pretomanid
ddn 3986699 c.-145C>G upstream_gene_variant 0.23 delamanid
pretomanid
clpC1 4038569 c.2136C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.29 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038620 p.Gln695Leu missense_variant 0.25 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.19 pyrazinamide
clpC1 4038644 p.Glu687Asp missense_variant 0.21 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.22 pyrazinamide
clpC1 4038670 c.2035C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038679 p.Pro676Ala missense_variant 0.24 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038704 c.2001T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038721 c.1984C>T synonymous_variant 0.28 pyrazinamide
clpC1 4038726 p.Thr660Cys missense_variant 0.29 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.41 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.47 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.32 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.32 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.33 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.33 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 0.35 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039037 c.1668T>G synonymous_variant 0.39 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039127 p.Lys526Asn missense_variant 0.29 pyrazinamide
clpC1 4039133 c.1572C>A synonymous_variant 0.32 pyrazinamide
clpC1 4039139 p.Glu522Asp missense_variant 0.34 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039165 c.1540C>T synonymous_variant 0.44 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.46 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039271 c.1434G>A synonymous_variant 0.58 pyrazinamide
clpC1 4039286 c.1417_1419delCTTinsTG frameshift_variant&synonymous_variant 0.54 pyrazinamide
clpC1 4039292 c.1413C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.48 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.48 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039451 c.1254G>A synonymous_variant 0.19 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039562 c.1143C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.3 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.24 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039582 p.Thr375Ser missense_variant 0.24 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039655 c.1050G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.43 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039733 c.972G>T synonymous_variant 0.38 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039840 c.865C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039855 c.850C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039880 c.825G>A synonymous_variant 0.42 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.55 pyrazinamide
clpC1 4039901 c.804C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039925 c.780C>G synonymous_variant 0.58 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039934 c.771G>T synonymous_variant 0.55 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.51 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.43 pyrazinamide
clpC1 4040001 p.His235Ala missense_variant 0.38 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040021 c.684A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040165 c.540G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040213 c.492T>G synonymous_variant 0.28 pyrazinamide
clpC1 4040225 c.480A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.32 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.42 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.44 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.26 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040315 p.Glu130Asp missense_variant 0.53 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.37 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.31 pyrazinamide
clpC1 4040363 c.342A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040369 c.336C>G synonymous_variant 0.36 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.31 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040444 c.261C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.52 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.48 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4040513 c.192G>A synonymous_variant 0.47 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040534 c.171A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040540 c.165G>C synonymous_variant 0.39 pyrazinamide
clpC1 4040546 c.159G>T synonymous_variant 0.37 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.38 pyrazinamide
clpC1 4040573 c.132T>G synonymous_variant 0.33 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.26 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040594 c.111G>A synonymous_variant 0.24 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCT frameshift_variant&missense_variant 0.24 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.23 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040618 c.87C>G synonymous_variant 0.36 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.35 pyrazinamide
clpC1 4040645 c.60C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040660 c.45G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040669 c.36C>T synonymous_variant 0.31 pyrazinamide
clpC1 4040695 c.10C>A synonymous_variant 0.3 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
panD 4044147 c.135C>G synonymous_variant 0.24 pyrazinamide
panD 4044150 c.132A>C synonymous_variant 0.24 pyrazinamide
panD 4044162 c.120A>G synonymous_variant 0.27 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.26 pyrazinamide
panD 4044180 p.Asp34Glu missense_variant 0.38 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.4 pyrazinamide
panD 4044189 c.93C>T synonymous_variant 0.4 pyrazinamide
panD 4044210 c.72C>A synonymous_variant 0.42 pyrazinamide
panD 4044216 c.66C>T synonymous_variant 0.39 pyrazinamide
panD 4044232 p.Cys17His missense_variant 0.27 pyrazinamide
panD 4044237 c.45G>C synonymous_variant 0.27 pyrazinamide
glpK 4138598 c.1158G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138682 c.1074C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138695 p.Pro354His missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>T synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 p.Ser346Val missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1030_1032delGCAinsAC frameshift_variant&missense_variant 0.44 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138751 c.1005T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138754 c.1002C>T synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.997_999delCTAinsTG frameshift_variant&synonymous_variant 0.36 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138775 c.981C>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138781 c.975G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240732 c.870C>T synonymous_variant 0.21 ethambutol
embC 4240765 c.903C>G synonymous_variant 0.3 ethambutol
embC 4240774 c.912C>G synonymous_variant 0.33 ethambutol
embC 4240778 c.916_918delCATinsAC frameshift_variant&missense_variant 0.33 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.34 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.37 ethambutol
embC 4240800 p.Tyr313Phe missense_variant 0.39 ethambutol
embC 4241129 c.1267C>T synonymous_variant 0.53 ethambutol
embC 4241135 p.Val425Leu missense_variant 0.55 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.58 ethambutol Not assoc w R - Interim
embC 4241158 c.1296T>C synonymous_variant 0.49 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embC 4241162 p.Leu434Met missense_variant 0.5 ethambutol
embC 4241167 c.1305C>G synonymous_variant 0.54 ethambutol
embC 4241168 c.1306C>T synonymous_variant 0.54 ethambutol Not assoc w R - Interim
embC 4241197 c.1335G>C synonymous_variant 0.39 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.39 ethambutol
embC 4241215 c.1353C>G synonymous_variant 0.29 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.21 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.21 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.23 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.21 ethambutol
embC 4241591 p.Leu577Ile missense_variant 0.22 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.24 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.24 ethambutol
embC 4241617 c.1755G>A synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242922 c.-311C>G upstream_gene_variant 0.27 ethambutol
embC 4242928 c.3066A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embA 4242940 c.-293T>C upstream_gene_variant 0.29 ethambutol
embC 4242941 p.His1027Asn missense_variant 0.29 ethambutol
embA 4242946 c.-287T>C upstream_gene_variant 0.31 ethambutol
embA 4242952 c.-281T>C upstream_gene_variant 0.28 ethambutol
embA 4242974 c.-259C>T upstream_gene_variant 0.28 ethambutol
embC 4242980 p.Met1040Val missense_variant 0.27 ethambutol
embA 4242988 c.-245A>G upstream_gene_variant 0.3 ethambutol
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244862 p.Leu544Val missense_variant 0.24 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.33 ethambutol
embB 4247462 c.949_950delTCinsAG synonymous_variant 0.45 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.41 ethambutol
embB 4247485 c.972C>T synonymous_variant 0.4 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.32 ethambutol
embB 4247494 c.981G>A synonymous_variant 0.29 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.29 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.29 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.41 ethambutol
embB 4247536 c.1023C>G synonymous_variant 0.36 ethambutol
embB 4247543 c.1030_1031delAGinsTC synonymous_variant 0.33 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.28 ethambutol
embB 4247555 c.1042_1044delCTGinsAC frameshift_variant&missense_variant 0.26 ethambutol
embB 4247563 p.Met350Ile missense_variant 0.24 ethambutol
embB 4247566 c.1053C>G synonymous_variant 0.28 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.28 ethambutol
embB 4247576 c.1063C>T synonymous_variant 0.27 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
aftB 4267647 p.Asp397Gly missense_variant 0.96 ethambutol Not assoc w R
aftB 4267732 p.Arg369Ser missense_variant 1.0 ethambutol
aftB 4268081 c.756A>G synonymous_variant 0.16 ethambutol
aftB 4268099 c.738G>C synonymous_variant 0.16 ethambutol
aftB 4268123 c.712_714delAGTinsGC frameshift_variant&synonymous_variant 0.2 ethambutol Uncertain significance
aftB 4268126 c.711G>C synonymous_variant 0.2 ethambutol
aftB 4268129 c.708T>G synonymous_variant 0.2 ethambutol
aftB 4268138 p.Gly233Ala missense_variant 0.19 ethambutol
aftB 4268144 c.693T>C synonymous_variant 0.2 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R