TB-Profiler result

Run: ERR4797193
Summary

Run ID: ERR4797193

Sample name:

Date: 2024-10-04T14:44:51.197172

Number of reads: 4335985

Percentage reads mapped: 60.61

Median coverage: 126.0

Strain: lineage1.1.2

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.1.2 Indo-Oceanic RD239 0.98
lineage1.1 Indo-Oceanic RD239 1.0
lineage1 Indo-Oceanic RD239 0.95
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin gyrA p.Asp94Gly Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Asp94Gly Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7582 p.Asp94Gly missense_variant 0.87 levofloxacin Assoc w R
moxifloxacin Assoc w R High-level resistance
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 ethionamide Assoc w R Alias fabG1_c.-15C>T
isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 633 c.633T>C synonymous_variant 0.17 isoniazid
dnaA 645 c.645A>G synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 717 c.717C>A synonymous_variant 0.15 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.14 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.13 isoniazid
gyrB 5635 c.396C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6112 p.Met291Ile missense_variant 0.93 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6124 c.885C>T synonymous_variant 0.88 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6160 c.921C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6193 c.954G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6196 c.957C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6203 c.964_966delAGCinsTCG synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6215 p.Ser326Thr missense_variant 0.27 levofloxacin
moxifloxacin
gyrB 6242 p.Arg335Lys missense_variant 0.23 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6808 c.1569C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7153 c.-149G>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7162 c.-140C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7412 c.111C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7415 c.114C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7436 c.135C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7520 c.219G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7529 c.228G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7532 c.231T>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7613 c.312G>A synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7631 c.330G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7667 c.366C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7671 p.Pro124Ala missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCGT synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7706 c.405C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGT synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8452 p.Ala384Val missense_variant 0.92 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8535 p.Glu412Gln missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8606 c.1305C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8609 c.1308G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8672 c.1371A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 0.99 isoniazid Not assoc w R
fgd1 491563 c.781_783delAGCinsTCG synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491601 c.819T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491604 c.822G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491616 c.834A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491620 p.Ile280Val missense_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491640 c.858G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491649 c.867C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491658 c.876A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491661 c.879C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491667 c.885A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491673 c.891A>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491676 c.894T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575713 c.366G>A synonymous_variant 0.14 isoniazid
ethionamide
mshA 575719 c.372C>T synonymous_variant 0.14 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575732 c.385_387delCTTinsTTG synonymous_variant 0.18 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.18 isoniazid
ethionamide
mshA 575744 p.Ala133Thr missense_variant 0.2 isoniazid Uncertain significance
ethionamide
mshA 575749 c.402C>G synonymous_variant 0.21 isoniazid
ethionamide
mshA 575771 p.Val142Thr missense_variant 0.23 isoniazid
ethionamide
mshA 575776 c.429C>T synonymous_variant 0.24 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.23 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575788 c.441C>T synonymous_variant 0.22 isoniazid
ethionamide
mshA 575795 p.Ile150Val missense_variant 0.23 isoniazid
ethionamide
mshA 575842 c.495G>C synonymous_variant 0.21 isoniazid
ethionamide
mshA 575845 c.498C>G synonymous_variant 0.21 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.19 isoniazid
ethionamide
mshA 576108 p.Ala254Gly missense_variant 0.25 isoniazid
ethionamide
ccsA 620649 c.759A>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620676 c.786C>T synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620694 c.804C>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620698 p.Val270Ile missense_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620724 c.834C>T synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620736 c.846G>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620742 c.852G>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620745 c.855G>A synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620766 c.876C>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620778 c.888T>C synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620783 p.Ala298Val missense_variant 0.14 kanamycin
capreomycin
amikacin
Rv0565c 656269 p.Met401Thr missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
nusG 734116 c.-138T>C upstream_gene_variant 1.0 rifampicin Not assoc w R
mmaA3 738080 p.Leu24Ile missense_variant 1.0 isoniazid
rpoB 759546 c.-261A>G upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760082 c.276C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760088 c.282C>G synonymous_variant 0.15 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760104 p.Ser100Thr missense_variant 0.15 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.15 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.16 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.17 rifampicin
rpoB 760145 c.339C>T synonymous_variant 0.18 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.36 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.38 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>T synonymous_variant 0.37 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.38 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.38 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.41 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.38 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.38 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.26 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760490 c.684C>T synonymous_variant 0.72 rifampicin Not assoc w R
rpoB 760514 c.708C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.21 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.19 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760571 c.765G>C synonymous_variant 0.15 rifampicin
rpoB 760585 p.Asn260Ser missense_variant 0.17 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.17 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.18 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.18 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760769 c.963C>G synonymous_variant 0.16 rifampicin
rpoB 760784 c.978G>C synonymous_variant 0.18 rifampicin
rpoB 760787 c.981G>C synonymous_variant 0.18 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.18 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.21 rifampicin
rpoB 760808 c.1002C>G synonymous_variant 0.22 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.2 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.19 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760829 c.1023C>T synonymous_variant 0.21 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.24 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 0.24 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.22 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.22 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.22 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.17 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.16 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.15 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.15 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.2 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.22 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.34 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.35 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761217 p.Pro471Ala missense_variant 0.15 rifampicin
rpoB 761220 p.Ser472Thr missense_variant 0.15 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.15 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.16 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761346 p.Val514Ile missense_variant 0.14 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.15 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761367 p.Glu521Gln missense_variant 0.15 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.15 rifampicin
rpoB 761615 c.1809A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.16 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.18 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.21 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.19 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.18 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.16 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.17 rifampicin
rpoB 761702 c.1896C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761708 c.1902C>T synonymous_variant 0.16 rifampicin
rpoB 761736 p.Ile644Val missense_variant 0.15 rifampicin Uncertain significance
rpoB 761747 c.1941G>C synonymous_variant 0.16 rifampicin
rpoB 761933 c.2127G>T synonymous_variant 0.15 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.22 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.23 rifampicin
rpoB 762038 c.2232C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.25 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.25 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.24 rifampicin
rpoB 762140 c.2334G>T synonymous_variant 0.25 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.26 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.27 rifampicin
rpoB 762293 c.2487T>G synonymous_variant 0.25 rifampicin
rpoB 762308 c.2502G>C synonymous_variant 0.24 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.21 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.18 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.18 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.21 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.18 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.18 rifampicin
rpoC 762374 c.-996G>T upstream_gene_variant 0.18 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.18 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762833 c.3027C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762839 c.-531G>A upstream_gene_variant 0.2 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762878 p.Ile1024Met missense_variant 0.26 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.26 rifampicin Uncertain significance
rpoB 762929 c.3123G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762989 c.3183G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.21 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.21 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.19 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.17 rifampicin
rpoC 763190 c.-180C>T upstream_gene_variant 0.15 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.22 rifampicin
rpoC 763484 c.115_117delCTTinsTTG synonymous_variant 0.22 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.27 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>T synonymous_variant 0.3 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.27 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.28 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>C synonymous_variant 0.27 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.27 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.28 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.28 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.28 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763783 c.414G>T synonymous_variant 0.19 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.17 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763884 p.Ala172Val missense_variant 0.82 rifampicin Not assoc w R
rpoC 763886 c.517C>A synonymous_variant 0.82 rifampicin Not assoc w R
rpoC 763891 c.522G>C synonymous_variant 0.16 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.16 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.18 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.18 rifampicin
rpoC 763940 p.Ala191Ser missense_variant 0.17 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.16 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.16 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.15 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.18 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.19 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.17 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Asn missense_variant 0.18 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.18 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.18 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.18 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.19 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.19 rifampicin
rpoC 764227 c.858G>T synonymous_variant 0.21 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764263 c.894G>C synonymous_variant 0.29 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.29 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.32 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.33 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.34 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.41 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>T synonymous_variant 0.29 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.29 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.3 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.31 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.35 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.33 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.3 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.3 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.26 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.25 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.21 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.21 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.21 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765171 p.Pro601Leu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765403 c.2034G>C synonymous_variant 0.16 rifampicin
rpoC 765404 p.Leu679Lys missense_variant 0.16 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.16 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.16 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 0.17 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 0.24 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.27 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.24 rifampicin Uncertain significance
rpoC 765496 c.2127C>G synonymous_variant 0.26 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>A synonymous_variant 0.2 rifampicin
rpoC 765533 p.Tyr722His missense_variant 0.19 rifampicin Uncertain significance
rpoC 765547 c.2178C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.15 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.15 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.14 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.16 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.18 rifampicin
rpoC 765800 p.Phe811Leu missense_variant 0.22 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.24 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.25 rifampicin
rpoC 765823 c.2454C>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.34 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.34 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.34 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.34 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.29 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.28 rifampicin
rpoC 765962 c.2593_2595delTTGinsCTT synonymous_variant 0.28 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766027 c.2658G>T synonymous_variant 0.15 rifampicin
rpoC 766034 p.His889Asn missense_variant 0.14 rifampicin
rpoC 766582 c.3213C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766675 c.3306C>T synonymous_variant 0.16 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.18 rifampicin
rpoC 766694 p.Gln1109Asp missense_variant 0.19 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.21 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.21 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.21 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.21 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.23 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.23 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.19 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.19 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.19 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.19 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766876 c.3507C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766883 p.Ser1172Ala missense_variant 0.2 rifampicin Uncertain significance
rpoC 766894 c.3525T>C synonymous_variant 0.2 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.2 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.21 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.22 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.22 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766921 c.3552G>C synonymous_variant 0.24 rifampicin
rpoC 766931 p.Ala1188Thr missense_variant 0.25 rifampicin Uncertain significance
rpoC 766942 c.3573C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766948 c.3579G>C synonymous_variant 0.2 rifampicin
rpoC 766960 c.3591C>T synonymous_variant 0.21 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.25 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767068 c.3699G>C synonymous_variant 0.28 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767105 p.Asn1246Gln missense_variant 0.19 rifampicin Uncertain significance
rpoC 767119 c.3750A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.16 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.16 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.16 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.16 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 0.99 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775754 c.2727C>G synonymous_variant 0.15 bedaquiline
clofazimine
mmpL5 775770 p.Ala904Gly missense_variant 0.15 bedaquiline
clofazimine
mmpL5 775772 p.Met903Ile missense_variant 0.15 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 775778 p.Thr901Ala missense_variant 0.15 bedaquiline
clofazimine
mmpL5 775793 c.2688C>G synonymous_variant 0.2 bedaquiline
clofazimine
mmpL5 775796 p.Phe895Met missense_variant 0.2 bedaquiline
clofazimine
mmpL5 775817 c.2664T>C synonymous_variant 0.36 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
mmpL5 775826 c.2655G>C synonymous_variant 0.32 bedaquiline
clofazimine
mmpL5 775829 c.2652C>G synonymous_variant 0.32 bedaquiline
clofazimine
mmpL5 775834 p.Ala883Ser missense_variant 0.32 bedaquiline
clofazimine
mmpL5 775838 c.2643G>C synonymous_variant 0.34 bedaquiline
clofazimine
mmpL5 775847 c.2634G>A synonymous_variant 0.4 bedaquiline
clofazimine
mmpL5 775851 p.Ser877Thr missense_variant 0.38 bedaquiline
clofazimine
mmpL5 775856 c.2625T>C synonymous_variant 0.42 bedaquiline
clofazimine
mmpL5 775862 c.2619G>C synonymous_variant 0.41 bedaquiline
clofazimine
mmpL5 775865 c.2616T>C synonymous_variant 0.38 bedaquiline
clofazimine
mmpL5 775885 p.Ile866Leu missense_variant 0.21 bedaquiline
clofazimine
mmpL5 775886 c.2595A>T synonymous_variant 0.23 bedaquiline
clofazimine
mmpL5 775889 c.2592C>G synonymous_variant 0.21 bedaquiline
clofazimine
mmpL5 775895 c.2586C>A synonymous_variant 0.36 bedaquiline
clofazimine
mmpL5 775904 c.2577G>A synonymous_variant 0.38 bedaquiline
clofazimine
mmpL5 775909 p.Leu858Phe missense_variant 0.34 bedaquiline
clofazimine
mmpL5 775910 c.2571G>A synonymous_variant 0.33 bedaquiline
clofazimine
mmpL5 775915 p.Ala856Ser missense_variant 0.34 bedaquiline
clofazimine
mmpL5 775916 c.2565T>C synonymous_variant 0.36 bedaquiline
clofazimine
mmpL5 775922 c.2559G>A synonymous_variant 0.4 bedaquiline
clofazimine
mmpL5 775946 c.2535C>G synonymous_variant 0.41 bedaquiline
clofazimine
mmpL5 775951 c.2530C>T synonymous_variant 0.39 bedaquiline
clofazimine
mmpL5 775955 p.Ile842Val missense_variant 0.22 bedaquiline
clofazimine
mmpL5 775961 c.2520C>G synonymous_variant 0.2 bedaquiline
clofazimine
mmpL5 775966 p.Ala839Ser missense_variant 0.16 bedaquiline
clofazimine
mmpL5 775973 p.Leu836Ile missense_variant 0.19 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.29 bedaquiline
clofazimine
mmpL5 775991 c.2490G>A synonymous_variant 0.22 bedaquiline
clofazimine
mmpL5 775996 p.Ile829Leu missense_variant 0.19 bedaquiline
clofazimine
mmpL5 775997 c.2484T>C synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 776000 p.Leu827Ile missense_variant 0.2 bedaquiline
clofazimine
mmpL5 776003 p.Ile826Leu missense_variant 0.2 bedaquiline
clofazimine
mmpL5 776009 c.2472A>G synonymous_variant 0.22 bedaquiline
clofazimine
mmpL5 776018 c.2463G>C synonymous_variant 0.26 bedaquiline
clofazimine
mmpL5 776030 c.2451G>C synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 776036 c.2445G>C synonymous_variant 0.28 bedaquiline
clofazimine
mmpL5 776045 c.2436G>C synonymous_variant 0.15 bedaquiline
clofazimine
mmpL5 776048 c.2433G>C synonymous_variant 0.26 bedaquiline
clofazimine
mmpL5 776053 c.2428T>C synonymous_variant 0.27 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776395 p.Phe696Leu missense_variant 0.99 bedaquiline Uncertain significance
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.14 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.17 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.19 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.21 streptomycin
rpsL 781664 c.105C>G synonymous_variant 0.22 streptomycin
rpsL 781667 c.108C>T synonymous_variant 0.24 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.27 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.27 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.25 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.25 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.24 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.23 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.22 streptomycin
rpsL 781737 p.Gln60Gly missense_variant 0.21 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.21 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.21 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.21 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.23 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.23 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.24 streptomycin Not assoc w R - Interim
rpsL 781793 c.234G>C synonymous_variant 0.25 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.24 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.25 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.23 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.24 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.24 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.24 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.26 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.25 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.26 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.27 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.26 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.26 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.26 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.25 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.19 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
rplC 800642 c.-167C>T upstream_gene_variant 0.14 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1304465 p.Gly512Asp missense_variant 0.13 pretomanid
delamanid
clofazimine
fbiC 1304472 c.1542T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304475 c.1545G>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1304481 c.1551T>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304490 c.1560C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304496 c.1566T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304499 c.1569T>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1304511 c.1581C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304515 p.Ala529Thr missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304526 c.1596T>A synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304546 p.Val539Ala missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304562 c.1632G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304571 c.1641G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304706 c.1776C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.18 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304736 c.1806G>A synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304739 c.1809C>G synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304751 c.1821C>G synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304766 c.1836C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
sigE 1364746 c.334C>T synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
sigE 1364784 c.372C>G synonymous_variant 0.15 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.16 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.16 pyrazinamide
sigE 1364814 c.402C>G synonymous_variant 0.16 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.15 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.14 pyrazinamide
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
atpE 1461132 p.Val30Ile missense_variant 0.13 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.34 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.32 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472032 n.187G>T non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472041 n.196C>G non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472848 n.1003T>A non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>T non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.48 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473811 n.154_155insT non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473814 n.158delT non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473829 n.172G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230delTinsAA non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474034 n.377G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474044 n.387C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474045 n.388C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474053 n.396G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474091 n.434C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474096 n.439C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474101 n.446_450delAGTAT non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474108 n.451C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474110 n.454_455insGGTGT non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474287 n.630_644delTCCTTTTCCTCTCCGinsCTCCTTC non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474303 n.646A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474417 n.761_767delCACGCGC non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474430 n.773delCinsTAG non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474432 n.775C>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474434 n.777_778insTG non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474437 n.781_782delAA non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474711 n.1054G>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475353 n.1696A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475354 n.1697A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475379 n.1722G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475381 n.1724G>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475382 n.1725A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475395 n.1738T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid Uncertain significance
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475398 n.1741C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.43 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476031 n.2374_2378delCCTCGinsTTCAC non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476746 n.3089T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
inhA 1674399 c.198A>G synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674418 p.Ser73Gly missense_variant 0.21 isoniazid
ethionamide
inhA 1674421 c.220T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674428 p.Gly76Asp missense_variant 0.26 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1674435 c.234G>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674444 c.243G>C synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674450 c.249G>T synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674471 c.270G>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674480 c.279T>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674486 c.285T>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674489 c.288G>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674503 p.Thr101Ser missense_variant 0.27 isoniazid
ethionamide
inhA 1674507 c.306G>T synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674513 c.312C>T synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674514 p.Ile105Val missense_variant 0.29 isoniazid
ethionamide
inhA 1674531 c.330C>T synonymous_variant 0.3 isoniazid
ethionamide
inhA 1674534 c.333G>T synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.28 isoniazid
ethionamide
inhA 1674546 c.345T>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674550 p.Ser117Ala missense_variant 0.22 isoniazid
ethionamide
inhA 1674573 c.372G>C synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674656 p.Ser152Thr missense_variant 0.14 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.14 isoniazid
ethionamide
inhA 1674732 c.531C>T synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674738 c.537C>G synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674746 p.Tyr182Phe missense_variant 0.21 isoniazid
ethionamide
inhA 1674756 c.555T>G synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674762 c.561T>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674771 c.570C>G synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674789 c.588G>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674795 c.594G>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674816 c.615T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674819 c.618G>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674822 c.621C>G synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674828 p.Glu209Asp missense_variant 0.19 isoniazid
ethionamide
inhA 1674834 c.633C>A synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674838 p.Ala213Lys missense_variant 0.19 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.21 isoniazid
ethionamide
inhA 1674852 c.651G>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674858 c.657G>A synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674879 c.678T>G synonymous_variant 0.22 isoniazid
ethionamide
rpsA 1833497 c.-45_-44insA upstream_gene_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833634 c.93G>A synonymous_variant 0.16 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833688 c.147C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.22 pyrazinamide
rpsA 1833745 c.204G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833796 c.255G>A synonymous_variant 0.22 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.2 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833862 c.321G>A synonymous_variant 0.19 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.21 pyrazinamide
rpsA 1833877 c.336C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.23 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.23 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.21 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834097 p.Ser186Thr missense_variant 0.16 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.15 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.24 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.27 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.24 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834482 p.Glu314Gly missense_variant 0.77 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.24 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.21 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.22 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.19 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.21 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.22 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.22 pyrazinamide
rpsA 1834774 c.1233C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.18 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834829 p.Ala430Thr missense_variant 0.15 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.17 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.18 linezolid
tsnR 1853375 c.-231G>T upstream_gene_variant 0.17 linezolid
tsnR 1853384 c.-222G>T upstream_gene_variant 0.19 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.19 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.19 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.17 linezolid
tsnR 1853417 c.-189G>C upstream_gene_variant 0.15 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.15 linezolid
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tsnR 1854045 p.Tyr147Cys missense_variant 1.0 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155696 p.Ala139Val missense_variant 0.13 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.16 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.18 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.18 isoniazid
katG 2155737 c.375C>T synonymous_variant 0.16 isoniazid
katG 2155742 p.Gly124Arg missense_variant 0.16 isoniazid
katG 2155743 c.369G>A synonymous_variant 0.16 isoniazid Not assoc w R - Interim
katG 2155747 p.Ala122Gly missense_variant 0.16 isoniazid
katG 2155752 c.360C>T synonymous_variant 0.16 isoniazid
katG 2155764 p.His116Gln missense_variant 0.16 isoniazid
katG 2155767 p.Ile115Val missense_variant 0.17 isoniazid
katG 2155770 c.342C>G synonymous_variant 0.17 isoniazid
katG 2155785 c.327T>C synonymous_variant 0.18 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2167983 p.Gly877Asp missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170785 c.-173T>C upstream_gene_variant 1.0 pyrazinamide
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517917 c.-198G>T upstream_gene_variant 0.18 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518173 p.Thr20Ile missense_variant 1.0 isoniazid
eis 2715016 p.Arg106His missense_variant 1.0 kanamycin Uncertain significance
amikacin Uncertain significance
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0 isoniazid
Rv2477c 2783563 c.480A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783568 p.Asn159His missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783584 p.Ala153Pro missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783626 p.Ala139Ser missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783634 p.Leu137Ile missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783651 p.His131Ala missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783671 p.Arg124His missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783689 c.354G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2681 2996912 c.174C>T synonymous_variant 1.0 capreomycin Not assoc w R
Rv2752c 3064632 c.1560C>T synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
Rv2752c 3065055 c.1137T>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065058 c.1134C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065061 c.1131C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065064 c.1128G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065082 c.1110G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065085 c.1105_1107delAGGinsCGC synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065088 c.1104A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065097 c.1095C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065109 c.1081_1083delAGAinsCGC synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065126 p.Ser356Ala missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065133 c.1059T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065142 c.1050A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065419 p.Arg258Leu missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
thyX 3067760 c.186G>A synonymous_variant 0.15 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
Rv3236c 3613309 c.-193G>A upstream_gene_variant 1.0 pyrazinamide
lpqB 3624486 p.Asp142Gly missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625702 c.-792C>T upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625705 c.-795C>A upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625711 c.903C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625741 c.-831G>A upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625747 c.867G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625753 p.Ala287Gln missense_variant 0.17 rifampicin
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626467 c.147G>A synonymous_variant 1.0 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.19 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.17 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.17 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.21 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.19 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.21 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.21 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877770 c.735_738delGTCAinsCAGC synonymous_variant 0.2 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.21 rifampicin
rpoA 3877803 c.705G>C synonymous_variant 0.21 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.22 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.23 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>C synonymous_variant 0.23 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.21 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.19 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.18 rifampicin Uncertain significance
rpoA 3877974 c.534G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878103 c.405A>G synonymous_variant 0.14 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.16 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.16 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.17 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.17 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878175 c.333G>T synonymous_variant 0.17 rifampicin
rpoA 3878187 c.321C>A synonymous_variant 0.17 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.16 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
clpC1 4038398 c.2307G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038401 c.2302_2304delTTGinsCTC synonymous_variant 0.17 pyrazinamide
clpC1 4038410 c.2295C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.23 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.23 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.25 pyrazinamide
clpC1 4038474 p.Ser744Ala missense_variant 0.23 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.24 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.23 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.25 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.23 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.17 pyrazinamide
clpC1 4038533 p.Arg724Gln missense_variant 0.17 pyrazinamide
clpC1 4038536 c.2169C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038563 c.2142C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038584 c.2121G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.17 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.16 pyrazinamide
clpC1 4038671 c.2034T>A synonymous_variant 0.15 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.15 pyrazinamide
clpC1 4038683 p.Ser674Thr missense_variant 0.15 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038721 c.1984C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.18 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.19 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039064 c.1641C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.16 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.16 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039124 c.1581C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039412 c.1293T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039565 c.1140G>T synonymous_variant 0.2 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.21 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039592 c.1113G>T synonymous_variant 0.24 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039616 c.1089G>T synonymous_variant 0.26 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039640 c.1065C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039901 c.804C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039925 c.780C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 0.25 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.26 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.31 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.25 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.24 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.19 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040278 p.Ser143Thr missense_variant 0.14 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040324 c.381G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.15 pyrazinamide
clpC1 4040433 c.271_272delAGinsTC synonymous_variant 0.15 pyrazinamide
clpC1 4040441 c.264C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040462 c.243C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040517 p.Val63Ala missense_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.15 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
panD 4044159 c.123C>T synonymous_variant 0.15 pyrazinamide
panD 4044162 c.120A>G synonymous_variant 0.15 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.15 pyrazinamide
panD 4044171 c.111C>T synonymous_variant 0.15 pyrazinamide
panD 4044740 c.-459C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4241042 p.Asn394Asp missense_variant 0.99 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243848 p.Val206Met missense_variant 1.0 ethambutol Not assoc w R
embA 4245969 p.Pro913Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4247488 c.975C>T synonymous_variant 0.14 ethambutol
embB 4247494 c.981G>A synonymous_variant 0.14 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.14 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.15 ethambutol
embB 4247511 p.Tyr333Phe missense_variant 0.14 ethambutol
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248106 c.1593C>G synonymous_variant 0.15 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.16 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.16 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.14 ethambutol
embB 4248143 p.Leu544Met missense_variant 0.14 ethambutol
embB 4248167 p.Thr552Ala missense_variant 0.15 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.15 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.16 ethambutol
embB 4248203 p.Pro564Ser missense_variant 0.16 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.16 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248225 p.Ala571Val missense_variant 0.15 ethambutol Uncertain significance
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269523 p.Thr104Ile missense_variant 1.0 ethambutol Uncertain significance
ubiA 4269606 c.228T>C synonymous_variant 0.98 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 1.0 streptomycin Not assoc w R