TB-Profiler result

Run: SRR5341412
Summary

Run ID: SRR5341412

Sample name:

Date: 2024-04-14T17:39:26.310585

Number of reads: 2129866

Percentage reads mapped: 54.77

Median coverage: 44.0

Strain: lineage3

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Leu430Pro Assoc w R
isoniazid katG c.372_373dupCG Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
pyrazinamide
streptomycin gid c.386delG Assoc w R
fluoroquinolones
moxifloxacin gyrA p.Ala90Val Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
p.Asp94Gly Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Ala90Val Assoc w R
p.Asp94Gly Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7570 p.Ala90Val missense_variant 0.62 levofloxacin Assoc w R
moxifloxacin Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
gyrA 7582 p.Asp94Gly missense_variant 0.15 levofloxacin Assoc w R
moxifloxacin Assoc w R High-level resistance
rpoB 761095 p.Leu430Pro missense_variant 0.57 rifampicin Assoc w R
katG 2155738 c.372_373dupCG frameshift_variant 1.0 isoniazid Assoc w R High-level resistance
embB 4247429 p.Met306Val missense_variant 0.85 ethambutol Assoc w R
gid 4407816 c.386delG frameshift_variant 0.66 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7355 c.54T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7763 c.462T>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.37 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8378 c.1077C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8408 c.1107A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8432 c.1131C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8942 c.1641G>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9197 c.1896G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9267 p.Asn656Gly missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 c.2007C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9323 c.2022C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9398 c.2097T>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9401 c.2100G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9413 c.2112G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9419 c.2118T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9420 p.Ile707Val missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
fgd1 491295 c.513C>G synonymous_variant 0.3 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491349 c.567T>C synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491364 c.582T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491546 p.Thr255Ser missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491563 c.781_782delAGinsTC synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491571 c.789C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575772 p.Val142Ala missense_variant 0.17 ethionamide
isoniazid
mshA 575776 c.429C>T synonymous_variant 0.18 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.19 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.18 ethionamide
isoniazid Not assoc w R - Interim
mshA 575821 c.474G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.16 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575869 c.522G>A synonymous_variant 0.21 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.18 ethionamide
isoniazid
ccsA 620625 c.735A>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620652 c.762C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 0.23 capreomycin
amikacin
kanamycin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
hadA 731753 c.-177A>G upstream_gene_variant 0.22 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.39 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.42 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 0.2 isoniazid
nusG 734439 c.186C>G synonymous_variant 0.28 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.3 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.33 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.38 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.27 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.24 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.38 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.34 rifampicin
nusG 734841 c.588G>C synonymous_variant 0.25 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.24 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.19 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.19 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.19 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.19 rifampicin
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760142 c.336C>G synonymous_variant 0.26 rifampicin
rpoB 760178 c.372G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.26 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.31 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.27 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.33 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.17 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.38 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.26 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.23 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 0.17 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.23 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.23 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.23 rifampicin Uncertain significance
rpoB 760925 c.1119T>C synonymous_variant 0.22 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.22 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.21 rifampicin Uncertain significance
rpoB 760982 c.1176G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.3 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.34 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.35 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.16 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.24 rifampicin
rpoB 761288 c.1482G>T synonymous_variant 0.24 rifampicin
rpoB 761318 c.1512G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.44 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 0.33 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.43 rifampicin
rpoB 761357 c.1551G>T synonymous_variant 0.14 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.41 rifampicin
rpoB 761367 p.Glu521Gln missense_variant 0.27 rifampicin
rpoB 761373 p.Val523His missense_variant 0.14 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.21 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.15 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761552 c.1746G>C synonymous_variant 0.19 rifampicin
rpoB 761555 c.1749G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.19 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.25 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.42 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.28 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.18 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.16 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.15 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.15 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.15 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.21 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.23 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.22 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.3 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.28 rifampicin
rpoB 761847 p.Cys681Arg missense_variant 0.22 rifampicin Uncertain significance
rpoB 761852 c.2046C>G synonymous_variant 0.2 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.18 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.19 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762006 c.2200_2202delCGCinsAT frameshift_variant&missense_variant 0.2 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.26 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Thr missense_variant 0.17 rifampicin Uncertain significance
rpoB 762029 c.2223C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.29 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.14 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.28 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.24 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.25 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762278 c.2472C>G synonymous_variant 0.16 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.2 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.31 rifampicin
rpoB 762287 c.2481C>T synonymous_variant 0.26 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762308 c.2502G>C synonymous_variant 0.15 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762335 c.2529C>T synonymous_variant 0.17 rifampicin
rpoB 762338 c.2532T>C synonymous_variant 0.31 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.16 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.29 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.3 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.28 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.27 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.22 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.29 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.27 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.25 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 0.62 rifampicin Not assoc w R
rpoC 762443 c.-927G>C upstream_gene_variant 0.21 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762490 p.Val895Ala missense_variant 0.15 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.32 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.32 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.18 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.27 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.25 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.25 rifampicin
rpoC 762575 c.-795C>T upstream_gene_variant 0.19 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.16 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.18 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.19 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.17 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762818 c.3012C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762989 c.3183G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.63 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.2 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763100 c.-270G>A upstream_gene_variant 0.17 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.31 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.23 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 0.39 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.29 rifampicin
rpoB 763203 p.Ser1133Ala missense_variant 0.24 rifampicin Uncertain significance
rpoB 763207 p.Ser1134Lys missense_variant 0.25 rifampicin Uncertain significance
rpoB 763214 c.3408T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763430 c.61A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763447 c.78C>T synonymous_variant 0.36 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.39 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>T synonymous_variant 0.15 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763609 c.240C>T synonymous_variant 0.26 rifampicin
rpoC 763621 c.252C>T synonymous_variant 0.27 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763705 c.336G>C synonymous_variant 0.16 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.42 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.18 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.24 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.18 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.15 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.17 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.16 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.14 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.14 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.15 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.17 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.17 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.17 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.26 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.3 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.29 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.35 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.33 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.17 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.16 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.24 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.23 rifampicin Uncertain significance
rpoC 764248 c.879C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764263 c.894G>C synonymous_variant 0.19 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.24 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.21 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.22 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.16 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.16 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.27 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.22 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.28 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.29 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.29 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.27 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.24 rifampicin
rpoC 764512 c.1143G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.33 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.28 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.4 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.44 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.43 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765079 c.1710T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765404 p.Leu679Met missense_variant 0.17 rifampicin
rpoC 765445 c.2076G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765453 p.Ala695Val missense_variant 0.29 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765526 c.2157C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765533 p.Tyr722His missense_variant 0.17 rifampicin Uncertain significance
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.26 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.24 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.18 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.2 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.33 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.33 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765817 c.2448G>C synonymous_variant 0.15 rifampicin
rpoC 765823 c.2454C>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.25 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.39 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.15 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765904 c.2535C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765961 c.2592G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766294 c.2925C>T synonymous_variant 0.15 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766345 c.2976T>C synonymous_variant 0.26 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766351 c.2982C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.33 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.19 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.31 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.31 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766390 c.3021C>T synonymous_variant 0.29 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.19 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.2 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.15 rifampicin
rpoC 766484 c.3115_3117delGTAinsAT frameshift_variant&missense_variant 0.28 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.17 rifampicin
rpoC 766517 p.Thr1050Ala missense_variant 0.29 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.21 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.22 rifampicin
rpoC 766564 c.3195C>G synonymous_variant 0.23 rifampicin
rpoC 766570 c.3201T>G synonymous_variant 0.23 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.2 rifampicin
rpoC 766607 c.3238_3240delATCinsTG frameshift_variant&missense_variant 0.2 rifampicin
rpoC 766610 p.Ser1081Pro missense_variant 0.19 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.25 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.18 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.16 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.15 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.23 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.22 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.17 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.25 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.26 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.24 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.27 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.28 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.22 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.2 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.31 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.31 rifampicin
rpoC 766787 p.Glu1140Gln missense_variant 0.18 rifampicin Uncertain significance
rpoC 766798 c.3429C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766981 c.3612T>C synonymous_variant 0.18 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767032 c.3663G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767035 c.3666G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.38 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>T synonymous_variant 0.17 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>T synonymous_variant 0.16 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.17 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.29 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775904 c.2577G>A synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.24 clofazimine
bedaquiline
mmpL5 775915 p.Ala856Ser missense_variant 0.22 clofazimine
bedaquiline
mmpL5 775916 c.2565T>C synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 775955 c.2524_2526delATCinsGG frameshift_variant&missense_variant 0.14 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775975 c.2506T>C synonymous_variant 0.15 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.18 clofazimine
bedaquiline
mmpL5 776081 c.2400G>C synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 776087 c.2394C>G synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776715 p.Lys589Pro missense_variant 0.26 clofazimine
bedaquiline
mmpL5 776733 p.Ser583Asn missense_variant 0.29 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776741 c.1740C>G synonymous_variant 0.29 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.3 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.27 streptomycin
rpsL 781608 c.49_51delAGTinsGC frameshift_variant&missense_variant 0.25 streptomycin Uncertain significance
rpsL 781628 c.69T>C synonymous_variant 0.29 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.33 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.23 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.23 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.28 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.27 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>G synonymous_variant 0.2 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.17 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.32 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.18 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.33 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.21 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.37 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.24 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.21 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.38 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.21 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.19 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.2 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.2 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.29 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.2 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.23 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.33 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.21 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.39 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.38 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.15 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.43 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.43 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.25 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.44 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.43 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.41 streptomycin Uncertain significance
rplC 800516 c.-293G>C upstream_gene_variant 0.2 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.15 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.24 linezolid
rplC 800558 c.-251G>A upstream_gene_variant 0.21 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.19 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.27 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.25 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.25 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.23 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.24 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.29 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.28 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.31 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.22 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.28 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 0.16 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.45 linezolid
rplC 800702 c.-107G>C upstream_gene_variant 0.27 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.42 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.4 linezolid
rplC 800744 c.-65G>C upstream_gene_variant 0.19 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.19 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.17 linezolid
rplC 800985 c.177A>G synonymous_variant 0.19 linezolid
rplC 801220 c.412_414delAGTinsGG frameshift_variant&missense_variant 0.21 linezolid
rplC 801228 c.420T>C synonymous_variant 0.16 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303545 c.615A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304562 c.1632G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304567 p.Phe546Tyr missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305361 c.2431C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1305399 c.2469A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838_839insTA non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473123 n.1278A>G non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473717 n.60G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052dupG non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1474711 n.1054_1055insA non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474715 n.1061delA non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475037 n.1380T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475482 n.1825A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475629 n.1972_1973insC non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
inhA 1673730 c.-472C>G upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.21 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.21 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.27 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.21 ethionamide
isoniazid
rpsA 1833661 c.120A>G synonymous_variant 0.36 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.35 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.33 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.4 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.15 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.17 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.16 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.23 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.17 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.24 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.19 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834042 p.Lys167Asn missense_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834051 c.510G>A synonymous_variant 0.21 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.26 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.47 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.2 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.35 pyrazinamide
rpsA 1834432 c.891G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.36 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834520 c.979_981delGCCinsTT frameshift_variant&missense_variant 0.18 pyrazinamide Uncertain significance
rpsA 1834540 c.999G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.17 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.16 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.32 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.37 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.27 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.25 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.29 pyrazinamide
rpsA 1834774 c.1233C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.24 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.15 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
kasA 2518528 c.414C>G synonymous_variant 0.19 isoniazid
kasA 2518564 c.450C>G synonymous_variant 0.15 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.17 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.25 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.19 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.18 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.18 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.2 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.25 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.23 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.16 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.22 isoniazid
kasA 2518787 p.Arg225Gly missense_variant 0.19 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
ahpC 2726116 c.-77T>A upstream_gene_variant 0.23 isoniazid Uncertain significance
ahpC 2726117 c.-76T>G upstream_gene_variant 0.71 isoniazid Uncertain significance
ahpC 2726657 c.465A>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ahpC 2726669 c.477T>C synonymous_variant 0.18 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.18 isoniazid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782498 c.1545C>T synonymous_variant 0.83 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
Rv2477c 2782501 c.1542T>C synonymous_variant 0.18 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783344 c.699C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.670_672delGAAinsCG frameshift_variant&missense_variant 0.31 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783386 c.657G>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783431 c.612C>T synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783440 c.603T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783743 c.300C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783935 c.108C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyX 3067355 c.591A>G synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3086987 p.Gln56His missense_variant 1.0 cycloserine
lpqB 3624680 c.231T>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624701 c.210T>G synonymous_variant 0.24 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625123 c.-213T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625753 p.Ala287Gln missense_variant 0.18 bedaquiline
rifampicin
lpqB 3625762 c.-852A>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625804 c.808_810delAGGinsCC frameshift_variant&missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625822 c.-912C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625837 c.777C>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626723 c.-110C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3626729 c.619_621delAAGinsCA frameshift_variant&missense_variant 0.18 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626750 c.-137T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3626756 c.594C>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626776 c.-163A>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626996 c.-383G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3627068 c.282T>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627083 c.-470G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627167 c.-554T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
fbiB 3642877 p.Lys448Arg missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
rpoA 3877545 c.963G>C synonymous_variant 0.17 rifampicin
rpoA 3877548 c.960C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877553 p.Glu319Gln missense_variant 0.19 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 0.24 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.27 rifampicin
rpoA 3877611 c.895_897delATCinsGG frameshift_variant&missense_variant 0.18 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.18 rifampicin
rpoA 3877638 c.870T>G synonymous_variant 0.18 rifampicin
rpoA 3877647 c.861C>T synonymous_variant 0.25 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.32 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877689 c.819C>G synonymous_variant 0.17 rifampicin
rpoA 3877692 c.816G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.34 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.21 rifampicin
rpoA 3877794 c.714G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.33 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.29 rifampicin
rpoA 3877875 c.633T>A synonymous_variant 0.27 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.21 rifampicin
rpoA 3877881 c.627G>C synonymous_variant 0.16 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.23 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.26 rifampicin
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.23 rifampicin
rpoA 3877935 c.573G>A synonymous_variant 0.17 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.4 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.16 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.16 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>C synonymous_variant 0.16 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878118 c.390T>C synonymous_variant 0.2 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.23 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878166 c.342C>G synonymous_variant 0.2 rifampicin
rpoA 3878172 c.336G>A synonymous_variant 0.18 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>A synonymous_variant 0.23 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.21 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.21 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3878264 p.Ser82Gly missense_variant 0.44 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.31 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.31 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.31 rifampicin
rpoA 3878394 c.114G>T synonymous_variant 0.22 rifampicin
rpoA 3878400 c.108T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878873 c.-366G>A upstream_gene_variant 0.17 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.23 rifampicin
rpoA 3878899 c.-392C>T upstream_gene_variant 0.25 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.27 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.3 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.25 rifampicin
rpoA 3878947 c.-440G>T upstream_gene_variant 0.16 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.14 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.21 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.22 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.23 rifampicin
rpoA 3879125 c.-618T>G upstream_gene_variant 0.23 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.22 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.22 rifampicin
clpC1 4038640 p.Asp689Asn missense_variant 0.24 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.23 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.23 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038704 c.2001T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038726 p.Thr660Cys missense_variant 0.2 pyrazinamide
clpC1 4038752 c.1953G>A synonymous_variant 0.23 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.37 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.42 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039064 c.1641C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.2 pyrazinamide
clpC1 4039100 c.1605C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039118 c.1587C>A synonymous_variant 0.21 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039271 c.1434G>A synonymous_variant 0.23 pyrazinamide
clpC1 4039286 c.1419T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.3 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.16 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.24 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039655 c.1050G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.27 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.16 pyrazinamide
clpC1 4039832 c.873C>A synonymous_variant 0.16 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039883 c.822G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039925 c.780C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.27 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.36 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.45 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040135 c.570C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040165 c.540G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040168 c.537G>T synonymous_variant 0.17 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.25 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.34 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040315 p.Glu130Asp missense_variant 0.26 pyrazinamide
clpC1 4040345 c.360C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.36 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.37 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.3 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.34 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.31 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040471 c.234T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040495 c.210C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040546 c.159G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.23 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.19 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138571 c.1185C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138622 c.1134C>T synonymous_variant 0.79 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138631 c.1125C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138661 c.1095T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138697 c.1059C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138727 c.1029C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138747 c.1009C>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139246 c.510C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R - Interim
glpK 4139602 c.154C>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139609 c.147C>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139637 p.Ala40Gly missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240765 c.903C>G synonymous_variant 0.17 ethambutol
embC 4240769 c.907_909delGTGinsAC frameshift_variant&missense_variant 0.16 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.21 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.28 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.28 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.18 ethambutol
embC 4241135 p.Val425Leu missense_variant 0.16 ethambutol
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242919 c.-314A>G upstream_gene_variant 0.18 ethambutol
embC 4242928 c.3066A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embA 4242940 c.-293T>C upstream_gene_variant 0.19 ethambutol
embA 4242973 c.-260G>A upstream_gene_variant 0.17 ethambutol
embB 4246544 p.Thr11Pro missense_variant 1.0 ethambutol Uncertain significance
embB 4247440 c.927C>G synonymous_variant 0.17 ethambutol
embB 4247449 c.936C>T synonymous_variant 0.16 ethambutol
embB 4247455 c.942C>T synonymous_variant 0.17 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.2 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.25 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.22 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.16 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.19 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.19 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.19 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248167 p.Thr552Ala missense_variant 0.18 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.18 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.21 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.18 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.19 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248225 p.Ala571Val missense_variant 0.18 ethambutol Uncertain significance
embB 4248242 p.Val577Ile missense_variant 0.2 ethambutol
embB 4248264 p.Phe584Cys missense_variant 0.23 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.29 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.24 ethambutol
aftB 4268105 c.732T>C synonymous_variant 0.16 ethambutol
aftB 4268125 p.Ser238Gly missense_variant 0.15 ethambutol
aftB 4268129 c.708T>G synonymous_variant 0.17 ethambutol
aftB 4268139 p.Gly233Ala missense_variant 0.14 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4408251 c.-49T>C upstream_gene_variant 1.0 streptomycin Uncertain significance