TB-Profiler result

Run: ERR4817667
Summary

Run ID: ERR4817667

Sample name:

Date: 2024-04-15T02:04:07.048320

Number of reads: 637459

Percentage reads mapped: 32.49

Median coverage: 12.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.421_423delTTGinsCC Assoc w R High-level resistance
c.349dupG Assoc w R High-level resistance
c.344delT Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155689 c.421_423delTTGinsCC frameshift_variant&missense_variant 0.5 isoniazid Assoc w R High-level resistance
katG 2155762 c.349dupG frameshift_variant 0.39 isoniazid Assoc w R High-level resistance
katG 2155767 c.344delT frameshift_variant 0.44 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 546 c.546C>G synonymous_variant 0.39 isoniazid
dnaA 567 c.567C>G synonymous_variant 0.39 isoniazid
dnaA 573 p.Leu191Phe missense_variant 0.39 isoniazid Uncertain significance
dnaA 577 p.Ile193Val missense_variant 0.43 isoniazid Uncertain significance
gyrB 6115 c.876A>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrB 6122 c.883_885delGCCinsTG frameshift_variant&missense_variant 0.42 levofloxacin Uncertain significance
moxifloxacin
gyrB 6127 c.888G>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrB 6130 c.891T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrB 6133 c.894G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrB 6139 c.900G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrB 6154 c.915C>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6160 c.921C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8305 p.Thr335Ser missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8340 c.1039_1041delGCGinsTC frameshift_variant&missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.76 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8894 c.1593C>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8934 p.Gln545Lys missense_variant 0.64 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8944 p.Gly548Asp missense_variant 0.57 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.57 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.53 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9026 c.1725G>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.37 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9092 c.1791C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9098 c.1797G>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 9113 c.1812C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0565c 656265 c.1204_1205delAC frameshift_variant 1.0 ethionamide Uncertain significance
hadA 731774 c.-156T>C upstream_gene_variant 0.52 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.55 isoniazid
hadA 731798 c.-132C>T upstream_gene_variant 0.54 isoniazid
hadA 731804 c.-126C>T upstream_gene_variant 0.48 isoniazid
hadA 731807 c.-123C>T upstream_gene_variant 0.46 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 0.46 isoniazid
hadA 731813 c.-117C>T upstream_gene_variant 0.45 isoniazid
hadA 731816 c.-114G>C upstream_gene_variant 0.45 isoniazid
hadA 731819 c.-111G>C upstream_gene_variant 0.45 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.41 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.44 rifampicin
nusG 734413 p.Ser54Thr missense_variant 0.55 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.56 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.5 rifampicin
nusG 734451 c.198G>T synonymous_variant 0.65 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.65 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
nusG 734463 c.210G>C synonymous_variant 0.63 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
nusG 734505 c.252G>C synonymous_variant 0.66 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
nusG 734543 p.Arg97Gln missense_variant 0.63 rifampicin
nusG 734549 p.Gln99Arg missense_variant 0.62 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.56 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.49 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
nusG 734658 c.405A>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 760088 c.282C>G synonymous_variant 0.3 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>C synonymous_variant 0.32 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.3 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.3 rifampicin Not assoc w R
rpoB 760118 c.312T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.39 rifampicin Uncertain significance
rpoB 760139 c.333A>C synonymous_variant 0.41 rifampicin
rpoB 760140 c.334_336delCCCinsTG frameshift_variant&missense_variant 0.41 rifampicin
rpoB 760143 p.Val113Ile missense_variant 0.56 rifampicin Uncertain significance
rpoB 760148 p.Asp114Glu missense_variant 0.62 rifampicin
rpoB 760157 c.351A>G synonymous_variant 0.68 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.68 rifampicin
rpoB 760233 c.427_429delAGTinsTCG synonymous_variant 0.61 rifampicin
rpoB 760241 c.435G>C synonymous_variant 0.55 rifampicin
rpoB 760244 c.438G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760271 c.465C>G synonymous_variant 0.59 rifampicin
rpoB 760274 p.Glu156Asp missense_variant 0.59 rifampicin Uncertain significance
rpoB 760283 c.477G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.44 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.42 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.42 rifampicin
rpoB 760317 c.511_513delAGCinsTCG synonymous_variant 0.42 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760340 c.534_535insC frameshift_variant 0.43 rifampicin
rpoB 760357 p.Thr184Asn missense_variant 0.68 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.79 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.79 rifampicin Uncertain significance
rpoB 760380 p.Thr192Pro missense_variant 0.78 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760407 p.Ser201Ala missense_variant 0.76 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760436 c.630C>G synonymous_variant 0.79 rifampicin
rpoB 760460 c.654G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.79 rifampicin
rpoB 760508 c.702G>C synonymous_variant 0.81 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.77 rifampicin
rpoB 760514 c.708C>G synonymous_variant 0.79 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Leu missense_variant 0.86 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760553 c.747C>G synonymous_variant 0.79 rifampicin
rpoB 760565 c.759A>C synonymous_variant 0.84 rifampicin
rpoB 760568 c.762G>C synonymous_variant 0.84 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.81 rifampicin
rpoB 760589 c.783C>G synonymous_variant 0.79 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.79 rifampicin
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.77 rifampicin
rpoB 760634 c.828T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.58 rifampicin
rpoB 760652 c.846C>G synonymous_variant 0.59 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.59 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.37 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760953 p.Ile383Leu missense_variant 0.33 rifampicin
rpoB 760958 c.1152G>C synonymous_variant 0.33 rifampicin
rpoB 760961 c.1155C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.34 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.35 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.41 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761058 p.Val418Ser missense_variant 0.5 rifampicin
rpoB 761063 c.1257C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761088 c.1282_1284delAGCinsTCG synonymous_variant 0.42 rifampicin
rpoB 761096 c.1290G>C synonymous_variant 0.38 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.38 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.38 rifampicin
rpoB 761126 c.1320G>C synonymous_variant 0.57 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761174 c.1368T>C synonymous_variant 0.7 rifampicin
rpoB 761180 c.1374A>G synonymous_variant 0.68 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761192 c.1386C>G synonymous_variant 0.7 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 0.69 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.35 rifampicin
rpoB 761519 p.Asp571Glu missense_variant 0.3 rifampicin
rpoB 761529 p.Val575Ile missense_variant 0.38 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761549 c.1743G>C synonymous_variant 0.57 rifampicin
rpoB 761555 c.1749G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.6 rifampicin
rpoB 761649 c.1843_1844delAGinsTC synonymous_variant 0.58 rifampicin
rpoB 761655 c.1849_1851delGCCinsTG frameshift_variant&missense_variant 0.53 rifampicin
rpoB 761661 c.1855C>T synonymous_variant 0.53 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.53 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.5 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.5 rifampicin
rpoB 761859 p.Asp685Asn missense_variant 0.5 rifampicin
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 0.5 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.44 rifampicin
rpoB 761885 c.2079T>A synonymous_variant 0.41 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.41 rifampicin
rpoB 761892 p.Ile696Leu missense_variant 0.41 rifampicin
rpoB 761903 c.2097T>A synonymous_variant 0.39 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.37 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.44 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.53 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.57 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.59 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.66 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.69 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.69 rifampicin
rpoB 762014 c.2208C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762026 c.2220G>C synonymous_variant 0.65 rifampicin
rpoB 762029 c.2223C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762032 c.2226C>G synonymous_variant 0.63 rifampicin
rpoB 762035 c.2229G>C synonymous_variant 0.63 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762074 c.2268C>G synonymous_variant 0.54 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.63 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.58 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.59 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.59 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762156 c.2350_2352delGTGinsAC frameshift_variant&missense_variant 0.67 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.78 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762251 c.2445G>C synonymous_variant 0.68 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.67 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.61 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.47 rifampicin
rpoB 762299 c.2493G>C synonymous_variant 0.47 rifampicin
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.7 rifampicin
rpoB 762905 p.Asp1033Glu missense_variant 0.83 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.78 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762989 c.3183G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.84 rifampicin
rpoC 763022 c.-348C>G upstream_gene_variant 0.85 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.89 rifampicin Not assoc w R
rpoB 763053 c.3247_3249delTTGinsCC frameshift_variant&missense_variant 0.85 rifampicin
rpoC 763067 c.-303C>G upstream_gene_variant 0.8 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.77 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.72 rifampicin
rpoC 763160 c.-210G>C upstream_gene_variant 0.68 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.59 rifampicin
rpoB 763172 c.3366G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763181 c.-189G>C upstream_gene_variant 0.63 rifampicin
rpoC 763187 c.-183C>G upstream_gene_variant 0.59 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763462 c.93G>C synonymous_variant 0.64 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.73 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.77 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.7 rifampicin
rpoC 763696 c.327T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.79 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.8 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.89 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.87 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.88 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.88 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.92 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.77 rifampicin
rpoC 763781 p.Ser138Glu missense_variant 0.77 rifampicin
rpoC 763796 p.Met143Gln missense_variant 0.74 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763812 p.Leu148Gln missense_variant 0.67 rifampicin
rpoC 764227 c.858G>C synonymous_variant 0.37 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.59 rifampicin
rpoC 764254 c.885G>A synonymous_variant 0.57 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.57 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.61 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.63 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.68 rifampicin
rpoC 764308 c.939G>C synonymous_variant 0.76 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.83 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.81 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.78 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.76 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.76 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.76 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.76 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.95 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.83 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.91 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>G synonymous_variant 0.94 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764656 c.1287C>G synonymous_variant 0.84 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764665 c.1296C>G synonymous_variant 0.84 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.78 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>C synonymous_variant 0.7 rifampicin
rpoC 764755 c.1386C>T synonymous_variant 0.7 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.61 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.68 rifampicin
rpoC 764803 c.1434C>G synonymous_variant 0.71 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.7 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764854 c.1485G>C synonymous_variant 0.72 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>T synonymous_variant 0.6 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.61 rifampicin
rpoC 764887 c.1518G>T synonymous_variant 0.64 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.61 rifampicin
rpoC 764902 c.1533C>G synonymous_variant 0.58 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.55 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.55 rifampicin Uncertain significance
rpoC 764917 c.1548G>C synonymous_variant 0.54 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.61 rifampicin
rpoC 764948 c.1579_1581delTTGinsCC frameshift_variant&missense_variant 0.57 rifampicin
rpoC 764953 c.1584G>C synonymous_variant 0.54 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765004 c.1635G>C synonymous_variant 0.51 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1643delAGinsTC synonymous_variant 0.56 rifampicin
rpoC 765016 c.1647C>G synonymous_variant 0.54 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.53 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.47 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.45 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.46 rifampicin
rpoC 765089 c.1720_1722delTTGinsCC frameshift_variant&missense_variant 0.46 rifampicin
rpoC 765100 c.1731G>C synonymous_variant 0.46 rifampicin
rpoC 765103 c.1734G>T synonymous_variant 0.44 rifampicin
rpoC 765121 c.1752G>T synonymous_variant 0.42 rifampicin
rpoC 765128 p.Tyr587His missense_variant 0.31 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.41 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765544 c.2175C>G synonymous_variant 0.53 rifampicin
rpoC 765547 c.2178C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.53 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.54 rifampicin
rpoC 765569 p.Ala734Ser missense_variant 0.54 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.56 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.56 rifampicin
rpoC 765590 p.Arg741Ser missense_variant 0.59 rifampicin Uncertain significance
rpoC 765600 p.Glu744Gly missense_variant 0.5 rifampicin Uncertain significance
rpoC 765610 c.2241C>T synonymous_variant 0.54 rifampicin
rpoC 765844 c.2475C>G synonymous_variant 0.5 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.81 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.74 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 765904 c.2535C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.66 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.55 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.55 rifampicin
rpoC 765955 c.2586C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593T>C synonymous_variant 0.57 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766321 c.2952C>G synonymous_variant 0.39 rifampicin
rpoC 766333 c.2964G>C synonymous_variant 0.32 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.33 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.37 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.39 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.39 rifampicin
rpoC 766375 c.3006C>G synonymous_variant 0.45 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.45 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.5 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.5 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766867 c.3498C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766885 c.3516G>C synonymous_variant 0.53 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.47 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.47 rifampicin
rpoC 766960 c.3591C>T synonymous_variant 0.73 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 766981 c.3612T>G synonymous_variant 0.69 rifampicin
rpoC 766990 c.3621G>C synonymous_variant 0.71 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>C synonymous_variant 0.56 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.64 rifampicin
rpoC 767017 c.3648C>G synonymous_variant 0.64 rifampicin
rpoC 767041 c.3672G>C synonymous_variant 0.67 rifampicin
rpoC 767044 c.3675G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781760 c.201T>C synonymous_variant 0.26 streptomycin
rpsL 781769 c.210G>A synonymous_variant 0.38 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.4 streptomycin Not assoc w R - Interim
rpsL 781781 c.222G>T synonymous_variant 0.53 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.67 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.66 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.69 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.7 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.72 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.77 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.77 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.75 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.76 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.78 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.79 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.73 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.74 streptomycin
rpsL 781901 c.342C>G synonymous_variant 0.74 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.73 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.71 streptomycin
rplC 800618 c.-191T>G upstream_gene_variant 0.32 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.4 linezolid
rplC 800645 c.-164C>T upstream_gene_variant 0.53 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.48 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.48 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.46 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.5 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.52 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.48 linezolid
rplC 800715 c.-94_-92delATCinsCG upstream_gene_variant 0.52 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.44 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.44 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.41 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.44 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.57 linezolid
fbiC 1304604 c.1674C>T synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304613 c.1683T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304628 c.1698G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471972 n.127T>C non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471981 n.136C>T non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472396 n.551A>T non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472431 n.586G>A non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>A non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472461 n.616G>T non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472467 n.622G>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>G non_coding_transcript_exon_variant 0.99 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473082 n.1237G>C non_coding_transcript_exon_variant 0.99 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.99 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.99 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.99 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.99 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>G non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473130 n.1285G>C non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473679 n.22T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473695 n.38A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1473793 n.136G>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1473797 n.140G>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1473802 n.145C>G non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_176delGGTGCGinsACGGTGT non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1473844 n.187C>A non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1473870 n.213G>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473933 n.276_277insAT non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1473936 n.281_282delGC non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1473968 n.311C>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474127 n.470G>A non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474139 n.482C>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474287 n.630_649delTCCTTTTCCTCTCCGGAGGAinsCTCGTT non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474498 n.841G>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474505 n.848C>T non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474674 n.1017A>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474675 n.1018C>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474718 n.1061_1062delAGinsGTGAGAA non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474822 n.1165G>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474896 n.1239A>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474902 n.1245T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>G non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475028 n.1371G>C non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475033 n.1376G>C non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475063 n.1406A>T non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475065 n.1408G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475084 n.1427G>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475109 n.1452C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475536 n.1879C>A non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475688 n.2031G>A non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475713 n.2056C>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101_2102delACinsG non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1475768 n.2111_2112delGTinsC non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.99 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476047 n.2390G>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476087 n.2430C>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476091 n.2434_2435insC non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.94 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.81 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.69 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833661 c.120A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.37 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.37 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.24 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833746 c.205_206delTCinsAG synonymous_variant 0.23 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.38 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.4 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.65 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.71 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.67 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.78 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.74 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.77 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.75 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.73 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.71 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.72 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.65 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.64 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.64 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.65 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.62 pyrazinamide
rpsA 1834000 c.459G>T synonymous_variant 0.64 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.66 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.65 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.67 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.65 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.67 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.64 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834255 c.714C>G synonymous_variant 0.53 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
rpsA 1834298 p.Gln253Thr missense_variant 0.7 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.7 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.7 pyrazinamide
rpsA 1834327 c.786G>C synonymous_variant 0.69 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.66 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
rpsA 1834384 c.843A>G synonymous_variant 0.63 pyrazinamide
rpsA 1834387 c.846C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.63 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.62 pyrazinamide
rpsA 1834408 c.867C>G synonymous_variant 0.58 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.7 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.75 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>C synonymous_variant 0.75 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.77 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.78 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.83 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.87 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.89 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.9 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.78 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.7 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.71 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834552 c.1011G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834556 p.Ala339Ser missense_variant 0.71 pyrazinamide
rpsA 1834570 c.1029C>T synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
rpsA 1834600 c.1059G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.69 pyrazinamide
rpsA 1834612 c.1071G>T synonymous_variant 0.68 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.68 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.65 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.73 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.76 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.88 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.87 pyrazinamide
rpsA 1834700 c.1159_1161delCAGinsAC frameshift_variant&missense_variant 0.84 pyrazinamide Uncertain significance
rpsA 1834706 c.1165_1167delAACinsGG frameshift_variant&missense_variant 0.81 pyrazinamide Uncertain significance
rpsA 1834733 p.Ala398Pro missense_variant 0.81 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.76 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.74 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.68 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.65 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.58 pyrazinamide
katG 2155655 p.Lys153Gln missense_variant 0.33 isoniazid Uncertain significance
katG 2155677 c.435C>G synonymous_variant 0.53 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.53 isoniazid
katG 2155696 p.Ala139Val missense_variant 0.53 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.48 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.41 isoniazid
katG 2155728 c.384G>T synonymous_variant 0.41 isoniazid
katG 2155736 p.Met126Leu missense_variant 0.41 isoniazid
katG 2155740 p.Gly124Ala missense_variant 0.41 isoniazid Uncertain significance
katG 2155743 c.369G>C synonymous_variant 0.39 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.39 isoniazid
katG 2155755 c.357C>T synonymous_variant 0.44 isoniazid Not assoc w R - Interim
katG 2155973 p.Val47Ile missense_variant 1.0 isoniazid Uncertain significance
Rv1979c 2222095 p.Ala357Val missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517921 c.-194_-193delACinsCT upstream_gene_variant 0.41 isoniazid
thyA 3073902 c.570C>G synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3073908 c.562_564delATGinsGC frameshift_variant&missense_variant 0.41 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.48 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.48 para-aminosalicylic_acid
thyA 3073950 c.522G>C synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3073965 c.507C>T synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073995 c.477G>C synonymous_variant 0.35 para-aminosalicylic_acid
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
rpoA 3877587 c.919_921delTCAinsGC frameshift_variant&missense_variant 0.61 rifampicin
rpoA 3877593 c.915C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877600 p.Gln303Ala missense_variant 0.58 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.74 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.76 rifampicin
rpoA 3877629 c.879C>G synonymous_variant 0.7 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877659 c.849G>T synonymous_variant 0.62 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.63 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.67 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877698 c.810C>T synonymous_variant 0.69 rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.64 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.63 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>C synonymous_variant 0.65 rifampicin
rpoA 3877752 p.Asp252Glu missense_variant 0.69 rifampicin
rpoA 3877764 c.742_744delGCCinsTG frameshift_variant&missense_variant 0.64 rifampicin
rpoA 3877770 c.736_738delTCAinsGG frameshift_variant&missense_variant 0.64 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>G synonymous_variant 0.76 rifampicin
rpoA 3877856 c.652T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 0.75 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>T synonymous_variant 0.73 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.62 rifampicin
rpoA 3877898 p.Pro204Ala missense_variant 0.61 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.6 rifampicin
rpoA 3877902 p.Ile202Met missense_variant 0.6 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3877935 p.Lys191Arg missense_variant 0.6 rifampicin
rpoA 3877938 c.570C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.71 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877998 c.510G>C synonymous_variant 0.59 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.59 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.67 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.67 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.68 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3878102 p.Val136Ile missense_variant 0.57 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.57 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.59 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.58 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.59 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.63 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Asp missense_variant 0.63 rifampicin Uncertain significance
rpoA 3878161 c.345_346delCG frameshift_variant 0.75 rifampicin
rpoA 3878166 c.341_342insGT frameshift_variant 0.75 rifampicin
rpoA 3878172 c.336G>C synonymous_variant 0.75 rifampicin
rpoA 3878175 c.333G>T synonymous_variant 0.76 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.75 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.73 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.71 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878217 c.289_291delCTAinsGG frameshift_variant&missense_variant 0.69 rifampicin
rpoA 3878241 p.Glu89Asp missense_variant 0.6 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.55 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.55 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.55 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.52 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.5 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.48 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.44 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.44 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.47 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.47 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038794 p.Ser637Thr missense_variant 0.56 pyrazinamide
clpC1 4038808 c.1896_1897insC frameshift_variant 0.74 pyrazinamide
clpC1 4038811 c.1893delT frameshift_variant 0.74 pyrazinamide
clpC1 4038860 c.1845G>T synonymous_variant 0.86 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4038896 c.1809C>G synonymous_variant 0.74 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.75 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.75 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.76 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.76 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.74 pyrazinamide
clpC1 4038926 c.1779G>C synonymous_variant 0.73 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.73 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.69 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.65 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.65 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.64 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.64 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4038986 p.Asp573Glu missense_variant 0.66 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.64 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.68 pyrazinamide
clpC1 4039016 c.1689C>G synonymous_variant 0.74 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.73 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.72 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.73 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.67 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.65 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.58 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.65 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.67 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.63 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCC frameshift_variant&missense_variant 0.62 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.64 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.64 pyrazinamide
clpC1 4039244 c.1461G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039499 c.1206G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.67 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.74 pyrazinamide
clpC1 4039642 p.Thr355Ala missense_variant 0.55 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039652 p.Thr351Cys missense_variant 0.53 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.68 pyrazinamide
clpC1 4039668 p.Gln346Leu missense_variant 0.24 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039673 p.Pro344His missense_variant 0.57 pyrazinamide
clpC1 4039691 c.1014G>T synonymous_variant 0.25 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039717 p.Lys330Gln missense_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.8 pyrazinamide
clpC1 4039729 p.Asp326Asn missense_variant 0.23 pyrazinamide Not assoc w R
clpC1 4039748 c.957G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.71 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.59 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.43 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.39 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.47 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039876 p.Asn277Asp missense_variant 0.55 pyrazinamide
clpC1 4039895 p.Lys270Arg missense_variant 0.63 pyrazinamide Uncertain significance
clpC1 4039898 c.807C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.7 pyrazinamide
clpC1 4039925 c.780C>T synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.57 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.68 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.7 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.7 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.71 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.72 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.78 pyrazinamide
clpC1 4039982 c.723G>C synonymous_variant 0.84 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.8 pyrazinamide
clpC1 4039994 c.709_711delGAGinsAC frameshift_variant&missense_variant 0.8 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.7 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.7 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.7 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.67 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.67 pyrazinamide
clpC1 4040045 c.660C>G synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.615T>G synonymous_variant 0.67 pyrazinamide
clpC1 4040093 c.612C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040107 p.Val200Ile missense_variant 0.62 pyrazinamide
clpC1 4040108 c.597G>C synonymous_variant 0.62 pyrazinamide
clpC1 4040117 c.588A>G synonymous_variant 0.57 pyrazinamide
clpC1 4040393 c.312G>T synonymous_variant 0.43 pyrazinamide
clpC1 4040411 c.294T>G synonymous_variant 0.47 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.5 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.47 pyrazinamide
clpC1 4040462 c.243C>G synonymous_variant 0.45 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.48 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.52 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.55 pyrazinamide
clpC1 4040486 c.219G>C synonymous_variant 0.61 pyrazinamide
clpC1 4040501 c.204C>G synonymous_variant 0.67 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>A synonymous_variant 0.6 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4040540 c.165G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.48 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim