TB-Profiler

TB-Profiler result

Run: SRR28119777

This average coverage of the target regions is below the recommended 30x. Some mutations may not be detected due to low coverage.

Summary

Run ID: SRR28119777

Sample name:

Date: 2024-05-22T19:36:36.212660

Number of reads: 471284

Percentage reads mapped: 35.02

Median coverage: 3.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	0.91
lineage4.9	Euro-American (H37Rv-like)	None	0.89

Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol	embB	p.His312Arg		Mutation from literature
ethambutol	embB	p.Ala388Gly		Mutation from literature
p.Asn399Asp		Mutation from literature
pyrazinamide
streptomycin	rrs	n.462C>T	Uncertain significance	Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid	fbiC	c.859_861delATCinsGG	Assoc w R - Interim	Confers DLM-PMD cross-resistance
delamanid	fbiC	c.2224_2226delTTGinsCA	Assoc w R - Interim	Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC	Assoc w R - Interim	Confers DLM-PMD cross-resistance
bedaquiline
linezolid

Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
fbiC	1303789	c.859_861delATCinsGG	frameshift_variant&missense_variant	1.0	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303789	c.859_861delATCinsGG	frameshift_variant&missense_variant	1.0	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1305154	c.2224_2226delTTGinsCA	frameshift_variant&missense_variant	0.92	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1305154	c.2224_2226delTTGinsCA	frameshift_variant&missense_variant	0.92	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1305331	c.2401_2403delGAAinsAC	frameshift_variant&missense_variant	1.0	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1305331	c.2401_2403delGAAinsAC	frameshift_variant&missense_variant	1.0	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
rrs	1472307	n.462C>T	non_coding_transcript_exon_variant	0.94	streptomycin	Uncertain significance	Mutation from literature
embB	4247448	p.His312Arg	missense_variant	1.0	ethambutol		Mutation from literature
embB	4247676	p.Ala388Gly	missense_variant	0.85	ethambutol		Mutation from literature
embB	4247708	p.Asn399Asp	missense_variant	0.89	ethambutol		Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	909	c.909A>C	synonymous_variant	0.8	isoniazid	Not assoc w R - Interim
dnaA	912	c.912T>G	synonymous_variant	0.8	isoniazid
dnaA	918	c.918C>G	synonymous_variant	0.8	isoniazid
dnaA	921	c.921A>G	synonymous_variant	0.8	isoniazid	Not assoc w R - Interim
dnaA	969	c.969G>A	synonymous_variant	0.7	isoniazid
dnaA	975	c.975G>T	synonymous_variant	0.7	isoniazid
dnaA	993	c.993A>G	synonymous_variant	0.7	isoniazid
dnaA	996	c.996A>C	synonymous_variant	0.7	isoniazid	Not assoc w R - Interim
dnaA	999	c.999C>G	synonymous_variant	0.7	isoniazid
dnaA	1092	c.1092T>C	synonymous_variant	0.73	isoniazid	Not assoc w R - Interim
dnaA	1098	c.1098A>G	synonymous_variant	0.76	isoniazid
dnaA	1104	c.1104T>C	synonymous_variant	0.76	isoniazid
dnaA	1110	c.1110T>C	synonymous_variant	0.76	isoniazid
dnaA	1113	c.1113A>G	synonymous_variant	0.76	isoniazid
dnaA	1125	c.1125G>C	synonymous_variant	0.85	isoniazid
dnaA	1137	c.1137C>G	synonymous_variant	0.88	isoniazid
dnaA	1143	c.1143G>C	synonymous_variant	0.92	isoniazid
dnaA	1152	c.1152A>G	synonymous_variant	0.96	isoniazid
dnaA	1153	c.1153T>C	synonymous_variant	0.96	isoniazid
dnaA	1161	c.1161A>G	synonymous_variant	0.96	isoniazid
dnaA	1164	c.1164A>C	synonymous_variant	0.96	isoniazid
dnaA	1167	c.1167A>G	synonymous_variant	0.96	isoniazid	Not assoc w R - Interim
dnaA	1176	c.1176A>G	synonymous_variant	0.96	isoniazid
dnaA	1188	c.1188G>A	synonymous_variant	0.96	isoniazid
dnaA	1191	c.1191T>C	synonymous_variant	0.96	isoniazid
dnaA	1197	c.1197T>C	synonymous_variant	1.0	isoniazid	Not assoc w R - Interim
dnaA	1204	c.1204C>T	synonymous_variant	1.0	isoniazid
dnaA	1220	p.Asn407Ser	missense_variant	1.0	isoniazid
dnaA	1230	c.1230A>G	synonymous_variant	1.0	isoniazid
gyrB	6123	p.Ala295Gly	missense_variant	0.8	levofloxacin
gyrB	6123	p.Ala295Gly	missense_variant	0.8	moxifloxacin
gyrB	6127	c.888G>C	synonymous_variant	0.8	levofloxacin
gyrB	6127	c.888G>C	synonymous_variant	0.8	moxifloxacin
gyrB	6130	c.891T>C	synonymous_variant	0.91	levofloxacin
gyrB	6130	c.891T>C	synonymous_variant	0.91	moxifloxacin
gyrB	6136	c.897G>A	synonymous_variant	0.83	levofloxacin	Not assoc w R - Interim
gyrB	6136	c.897G>A	synonymous_variant	0.83	moxifloxacin
gyrB	6139	c.900G>C	synonymous_variant	0.85	levofloxacin
gyrB	6139	c.900G>C	synonymous_variant	0.85	moxifloxacin
gyrB	6238	c.999G>A	synonymous_variant	0.91	levofloxacin	Not assoc w R - Interim
gyrB	6238	c.999G>A	synonymous_variant	0.91	moxifloxacin	Not assoc w R - Interim
gyrB	6242	p.Arg335Lys	missense_variant	0.91	levofloxacin
gyrB	6242	p.Arg335Lys	missense_variant	0.91	moxifloxacin
gyrB	6250	c.1011A>G	synonymous_variant	0.91	levofloxacin	Not assoc w R - Interim
gyrB	6250	c.1011A>G	synonymous_variant	0.91	moxifloxacin	Not assoc w R - Interim
gyrB	6256	c.1017G>A	synonymous_variant	0.93	levofloxacin
gyrB	6256	c.1017G>A	synonymous_variant	0.93	moxifloxacin
gyrB	6268	c.1029C>G	synonymous_variant	0.98	levofloxacin
gyrB	6268	c.1029C>G	synonymous_variant	0.98	moxifloxacin
gyrB	6280	c.1041T>C	synonymous_variant	0.95	levofloxacin
gyrB	6280	c.1041T>C	synonymous_variant	0.95	moxifloxacin
gyrB	6286	c.1047T>C	synonymous_variant	0.95	levofloxacin
gyrB	6286	c.1047T>C	synonymous_variant	0.95	moxifloxacin
gyrB	6289	c.1050C>T	synonymous_variant	0.95	levofloxacin
gyrB	6289	c.1050C>T	synonymous_variant	0.95	moxifloxacin
gyrB	6292	c.1053G>C	synonymous_variant	0.95	levofloxacin
gyrB	6292	c.1053G>C	synonymous_variant	0.95	moxifloxacin
gyrB	6307	c.1068T>G	synonymous_variant	0.95	levofloxacin	Not assoc w R - Interim
gyrB	6307	c.1068T>G	synonymous_variant	0.95	moxifloxacin	Not assoc w R - Interim
gyrB	6319	c.1080G>C	synonymous_variant	0.94	levofloxacin	Not assoc w R - Interim
gyrB	6319	c.1080G>C	synonymous_variant	0.94	moxifloxacin
gyrA	6362	c.-940T>C	upstream_gene_variant	0.86	levofloxacin
gyrA	6362	c.-940T>C	upstream_gene_variant	0.86	moxifloxacin
gyrA	6376	c.-926G>A	upstream_gene_variant	0.87	levofloxacin
gyrA	6376	c.-926G>A	upstream_gene_variant	0.87	moxifloxacin
gyrA	6379	c.-923C>G	upstream_gene_variant	0.86	levofloxacin
gyrA	6379	c.-923C>G	upstream_gene_variant	0.86	moxifloxacin
gyrA	6382	c.-920A>G	upstream_gene_variant	0.86	levofloxacin
gyrA	6382	c.-920A>G	upstream_gene_variant	0.86	moxifloxacin
gyrA	6388	c.-914T>C	upstream_gene_variant	0.86	levofloxacin
gyrA	6388	c.-914T>C	upstream_gene_variant	0.86	moxifloxacin
gyrA	6403	c.-899T>C	upstream_gene_variant	0.82	levofloxacin
gyrA	6403	c.-899T>C	upstream_gene_variant	0.82	moxifloxacin
gyrA	6415	c.-887G>C	upstream_gene_variant	0.77	levofloxacin
gyrA	6415	c.-887G>C	upstream_gene_variant	0.77	moxifloxacin
gyrA	6598	c.-704C>G	upstream_gene_variant	1.0	levofloxacin
gyrA	6598	c.-704C>G	upstream_gene_variant	1.0	moxifloxacin
gyrA	6610	c.-692C>G	upstream_gene_variant	1.0	levofloxacin
gyrA	6610	c.-692C>G	upstream_gene_variant	1.0	moxifloxacin
gyrA	6613	c.-689A>G	upstream_gene_variant	1.0	levofloxacin
gyrA	6613	c.-689A>G	upstream_gene_variant	1.0	moxifloxacin
gyrA	6616	c.-686A>G	upstream_gene_variant	1.0	levofloxacin
gyrA	6616	c.-686A>G	upstream_gene_variant	1.0	moxifloxacin
gyrA	6622	c.-680C>T	upstream_gene_variant	1.0	levofloxacin
gyrA	6622	c.-680C>T	upstream_gene_variant	1.0	moxifloxacin
gyrA	6634	c.-668T>C	upstream_gene_variant	1.0	levofloxacin
gyrA	6634	c.-668T>C	upstream_gene_variant	1.0	moxifloxacin
gyrA	6637	c.-665T>A	upstream_gene_variant	1.0	levofloxacin
gyrA	6637	c.-665T>A	upstream_gene_variant	1.0	moxifloxacin
gyrA	6640	c.-662A>G	upstream_gene_variant	1.0	levofloxacin
gyrA	6640	c.-662A>G	upstream_gene_variant	1.0	moxifloxacin
gyrA	6643	c.-659A>G	upstream_gene_variant	1.0	levofloxacin
gyrA	6643	c.-659A>G	upstream_gene_variant	1.0	moxifloxacin
gyrA	6646	c.-656C>T	upstream_gene_variant	1.0	levofloxacin
gyrA	6646	c.-656C>T	upstream_gene_variant	1.0	moxifloxacin
gyrA	6649	c.-653T>C	upstream_gene_variant	1.0	levofloxacin
gyrA	6649	c.-653T>C	upstream_gene_variant	1.0	moxifloxacin
gyrA	6655	c.-647T>C	upstream_gene_variant	1.0	levofloxacin
gyrA	6655	c.-647T>C	upstream_gene_variant	1.0	moxifloxacin
gyrA	6670	c.-632G>C	upstream_gene_variant	1.0	levofloxacin
gyrA	6670	c.-632G>C	upstream_gene_variant	1.0	moxifloxacin
gyrA	6673	c.-629A>C	upstream_gene_variant	1.0	levofloxacin
gyrA	6673	c.-629A>C	upstream_gene_variant	1.0	moxifloxacin
gyrA	6676	c.-626T>G	upstream_gene_variant	1.0	levofloxacin
gyrA	6676	c.-626T>G	upstream_gene_variant	1.0	moxifloxacin
gyrB	6680	c.1441C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6680	c.1441C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	6700	c.-602T>C	upstream_gene_variant	1.0	levofloxacin
gyrA	6700	c.-602T>C	upstream_gene_variant	1.0	moxifloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	1.0	levofloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	1.0	moxifloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	1.0	levofloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	1.0	moxifloxacin
gyrA	6712	c.-590G>C	upstream_gene_variant	1.0	levofloxacin
gyrA	6712	c.-590G>C	upstream_gene_variant	1.0	moxifloxacin
gyrB	6728	c.1489_1491delCTAinsTG	frameshift_variant&stop_gained	1.0	levofloxacin	Uncertain significance
gyrB	6728	c.1489_1491delCTAinsTG	frameshift_variant&stop_gained	1.0	moxifloxacin
gyrA	6742	c.-560A>G	upstream_gene_variant	1.0	levofloxacin
gyrA	6742	c.-560A>G	upstream_gene_variant	1.0	moxifloxacin
gyrB	6745	c.1506T>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6745	c.1506T>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	6751	c.-551G>C	upstream_gene_variant	1.0	levofloxacin
gyrA	6751	c.-551G>C	upstream_gene_variant	1.0	moxifloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	1.0	levofloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	1.0	moxifloxacin
gyrB	6763	c.1524G>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6763	c.1524G>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6775	c.1536G>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6775	c.1536G>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6793	c.1554T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6793	c.1554T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6797	p.Gly520Thr	missense_variant	1.0	levofloxacin
gyrB	6797	p.Gly520Thr	missense_variant	1.0	moxifloxacin
gyrA	7763	c.462T>C	synonymous_variant	0.87	levofloxacin	Not assoc w R - Interim
gyrA	7763	c.462T>C	synonymous_variant	0.87	moxifloxacin	Not assoc w R - Interim
gyrA	7775	c.474C>A	synonymous_variant	0.81	levofloxacin
gyrA	7775	c.474C>A	synonymous_variant	0.81	moxifloxacin
gyrA	7781	c.480G>C	synonymous_variant	0.81	levofloxacin
gyrA	7781	c.480G>C	synonymous_variant	0.81	moxifloxacin
gyrA	7784	c.483A>G	synonymous_variant	0.81	levofloxacin
gyrA	7784	c.483A>G	synonymous_variant	0.81	moxifloxacin
gyrA	7790	c.489G>C	synonymous_variant	0.81	levofloxacin
gyrA	7790	c.489G>C	synonymous_variant	0.81	moxifloxacin
gyrA	7793	c.492G>C	synonymous_variant	0.81	levofloxacin
gyrA	7793	c.492G>C	synonymous_variant	0.81	moxifloxacin
gyrA	7796	c.495G>C	synonymous_variant	0.81	levofloxacin
gyrA	7796	c.495G>C	synonymous_variant	0.81	moxifloxacin
gyrA	7799	c.498A>G	synonymous_variant	0.81	levofloxacin	Not assoc w R - Interim
gyrA	7799	c.498A>G	synonymous_variant	0.81	moxifloxacin	Not assoc w R - Interim
gyrA	7814	c.513C>G	synonymous_variant	0.81	levofloxacin	Not assoc w R - Interim
gyrA	7814	c.513C>G	synonymous_variant	0.81	moxifloxacin	Not assoc w R - Interim
gyrA	7823	c.522G>C	synonymous_variant	0.81	levofloxacin
gyrA	7823	c.522G>C	synonymous_variant	0.81	moxifloxacin
gyrA	7832	c.531G>T	synonymous_variant	0.79	levofloxacin
gyrA	7832	c.531G>T	synonymous_variant	0.79	moxifloxacin
gyrA	7835	c.534A>C	synonymous_variant	0.85	levofloxacin
gyrA	7835	c.534A>C	synonymous_variant	0.85	moxifloxacin
gyrA	7853	c.552C>G	synonymous_variant	0.85	levofloxacin
gyrA	7853	c.552C>G	synonymous_variant	0.85	moxifloxacin
gyrA	7859	c.558A>G	synonymous_variant	0.79	levofloxacin
gyrA	7859	c.558A>G	synonymous_variant	0.79	moxifloxacin
gyrA	8069	c.768T>C	synonymous_variant	0.92	levofloxacin
gyrA	8069	c.768T>C	synonymous_variant	0.92	moxifloxacin
gyrA	8078	c.777A>G	synonymous_variant	1.0	levofloxacin
gyrA	8078	c.777A>G	synonymous_variant	1.0	moxifloxacin
gyrA	8090	c.789C>A	synonymous_variant	1.0	levofloxacin
gyrA	8090	c.789C>A	synonymous_variant	1.0	moxifloxacin
gyrA	8093	c.792C>T	synonymous_variant	1.0	levofloxacin
gyrA	8093	c.792C>T	synonymous_variant	1.0	moxifloxacin
gyrA	8096	c.795T>A	synonymous_variant	1.0	levofloxacin
gyrA	8096	c.795T>A	synonymous_variant	1.0	moxifloxacin
gyrA	8099	c.798T>C	synonymous_variant	1.0	levofloxacin
gyrA	8099	c.798T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8111	c.810G>C	synonymous_variant	1.0	levofloxacin
gyrA	8111	c.810G>C	synonymous_variant	1.0	moxifloxacin
gyrA	8121	c.820T>C	synonymous_variant	1.0	levofloxacin
gyrA	8121	c.820T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8129	c.828T>C	synonymous_variant	1.0	levofloxacin
gyrA	8129	c.828T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8135	c.834C>G	synonymous_variant	1.0	levofloxacin
gyrA	8135	c.834C>G	synonymous_variant	1.0	moxifloxacin
gyrA	8156	c.855T>C	synonymous_variant	1.0	levofloxacin
gyrA	8156	c.855T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8168	c.867A>G	synonymous_variant	1.0	levofloxacin
gyrA	8168	c.867A>G	synonymous_variant	1.0	moxifloxacin
gyrA	8172	p.Val291Ile	missense_variant	1.0	levofloxacin
gyrA	8172	p.Val291Ile	missense_variant	1.0	moxifloxacin
gyrA	8177	c.876A>C	synonymous_variant	1.0	levofloxacin
gyrA	8177	c.876A>C	synonymous_variant	1.0	moxifloxacin
gyrA	8198	c.897T>C	synonymous_variant	0.97	levofloxacin	Not assoc w R - Interim
gyrA	8198	c.897T>C	synonymous_variant	0.97	moxifloxacin	Not assoc w R - Interim
gyrA	8207	c.906T>C	synonymous_variant	0.97	levofloxacin
gyrA	8207	c.906T>C	synonymous_variant	0.97	moxifloxacin
gyrA	8219	c.918T>C	synonymous_variant	0.97	levofloxacin	Not assoc w R - Interim
gyrA	8219	c.918T>C	synonymous_variant	0.97	moxifloxacin	Not assoc w R - Interim
gyrA	8225	c.924T>C	synonymous_variant	0.97	levofloxacin
gyrA	8225	c.924T>C	synonymous_variant	0.97	moxifloxacin
gyrA	8234	c.933T>C	synonymous_variant	0.96	levofloxacin
gyrA	8234	c.933T>C	synonymous_variant	0.96	moxifloxacin
gyrA	8237	c.936A>G	synonymous_variant	0.96	levofloxacin
gyrA	8237	c.936A>G	synonymous_variant	0.96	moxifloxacin
gyrA	8247	c.946_948delATCinsGG	frameshift_variant&missense_variant	0.96	levofloxacin
gyrA	8247	c.946_948delATCinsGG	frameshift_variant&missense_variant	0.96	moxifloxacin
gyrA	8264	c.963T>C	synonymous_variant	0.93	levofloxacin
gyrA	8264	c.963T>C	synonymous_variant	0.93	moxifloxacin
gyrA	8267	c.966G>C	synonymous_variant	0.93	levofloxacin	Not assoc w R - Interim
gyrA	8267	c.966G>C	synonymous_variant	0.93	moxifloxacin	Not assoc w R - Interim
gyrA	8270	c.969G>C	synonymous_variant	0.93	levofloxacin
gyrA	8270	c.969G>C	synonymous_variant	0.93	moxifloxacin
gyrA	8276	c.975G>A	synonymous_variant	0.93	levofloxacin
gyrA	8276	c.975G>A	synonymous_variant	0.93	moxifloxacin
gyrA	8283	c.982_984delATCinsCG	frameshift_variant&missense_variant	0.92	levofloxacin
gyrA	8283	c.982_984delATCinsCG	frameshift_variant&missense_variant	0.92	moxifloxacin
gyrA	8288	c.987T>C	synonymous_variant	0.92	levofloxacin	Not assoc w R - Interim
gyrA	8288	c.987T>C	synonymous_variant	0.92	moxifloxacin	Not assoc w R - Interim
gyrA	8294	c.993T>C	synonymous_variant	0.94	levofloxacin	Not assoc w R - Interim
gyrA	8294	c.993T>C	synonymous_variant	0.94	moxifloxacin	Not assoc w R - Interim
gyrA	8324	c.1023T>C	synonymous_variant	0.9	levofloxacin
gyrA	8324	c.1023T>C	synonymous_variant	0.9	moxifloxacin
gyrA	8330	c.1029C>G	synonymous_variant	0.88	levofloxacin	Not assoc w R - Interim
gyrA	8330	c.1029C>G	synonymous_variant	0.88	moxifloxacin	Not assoc w R - Interim
gyrA	8339	c.1038A>G	synonymous_variant	0.88	levofloxacin
gyrA	8339	c.1038A>G	synonymous_variant	0.88	moxifloxacin
gyrA	8340	p.Ala347Ser	missense_variant	0.92	levofloxacin	Uncertain significance
gyrA	8340	p.Ala347Ser	missense_variant	0.92	moxifloxacin	Uncertain significance
gyrA	8372	c.1071G>C	synonymous_variant	0.89	levofloxacin
gyrA	8372	c.1071G>C	synonymous_variant	0.89	moxifloxacin
gyrA	8375	c.1074G>C	synonymous_variant	0.89	levofloxacin	Not assoc w R - Interim
gyrA	8375	c.1074G>C	synonymous_variant	0.89	moxifloxacin
gyrA	8382	p.Leu361Met	missense_variant	0.88	levofloxacin
gyrA	8382	p.Leu361Met	missense_variant	0.88	moxifloxacin
gyrA	8387	c.1086C>T	synonymous_variant	0.85	levofloxacin	Not assoc w R - Interim
gyrA	8387	c.1086C>T	synonymous_variant	0.85	moxifloxacin	Not assoc w R - Interim
gyrA	8391	c.1090_1092delTATinsCC	frameshift_variant&missense_variant	0.88	levofloxacin
gyrA	8391	c.1090_1092delTATinsCC	frameshift_variant&missense_variant	0.88	moxifloxacin
gyrA	8399	c.1098T>G	synonymous_variant	0.91	levofloxacin
gyrA	8399	c.1098T>G	synonymous_variant	0.91	moxifloxacin
gyrA	8401	p.Asp367Ala	missense_variant	0.91	levofloxacin
gyrA	8401	p.Asp367Ala	missense_variant	0.91	moxifloxacin
gyrA	8405	c.1104C>T	synonymous_variant	0.92	levofloxacin
gyrA	8405	c.1104C>T	synonymous_variant	0.92	moxifloxacin
gyrA	8420	c.1119T>C	synonymous_variant	0.93	levofloxacin
gyrA	8420	c.1119T>C	synonymous_variant	0.93	moxifloxacin
gyrA	8442	c.1141C>T	synonymous_variant	0.94	levofloxacin
gyrA	8442	c.1141C>T	synonymous_variant	0.94	moxifloxacin
gyrA	8453	c.1152A>C	synonymous_variant	0.92	levofloxacin
gyrA	8453	c.1152A>C	synonymous_variant	0.92	moxifloxacin
gyrA	8459	c.1158G>A	synonymous_variant	0.91	levofloxacin
gyrA	8459	c.1158G>A	synonymous_variant	0.91	moxifloxacin
gyrA	8462	c.1161A>T	synonymous_variant	0.91	levofloxacin
gyrA	8462	c.1161A>T	synonymous_variant	0.91	moxifloxacin
gyrA	8465	c.1164C>G	synonymous_variant	0.95	levofloxacin
gyrA	8465	c.1164C>G	synonymous_variant	0.95	moxifloxacin
gyrA	8471	c.1170T>C	synonymous_variant	0.95	levofloxacin
gyrA	8471	c.1170T>C	synonymous_variant	0.95	moxifloxacin
gyrA	8472	c.1171C>T	synonymous_variant	0.95	levofloxacin
gyrA	8472	c.1171C>T	synonymous_variant	0.95	moxifloxacin
gyrA	8480	c.1179C>A	synonymous_variant	0.95	levofloxacin
gyrA	8480	c.1179C>A	synonymous_variant	0.95	moxifloxacin
gyrA	8486	c.1185T>C	synonymous_variant	0.95	levofloxacin	Not assoc w R - Interim
gyrA	8486	c.1185T>C	synonymous_variant	0.95	moxifloxacin	Not assoc w R - Interim
gyrA	8504	c.1203G>C	synonymous_variant	0.85	levofloxacin
gyrA	8504	c.1203G>C	synonymous_variant	0.85	moxifloxacin
gyrA	8516	c.1215T>C	synonymous_variant	0.93	levofloxacin
gyrA	8516	c.1215T>C	synonymous_variant	0.93	moxifloxacin
gyrA	8519	c.1218A>C	synonymous_variant	1.0	levofloxacin
gyrA	8519	c.1218A>C	synonymous_variant	1.0	moxifloxacin
gyrA	8520	c.1219C>T	synonymous_variant	1.0	levofloxacin
gyrA	8520	c.1219C>T	synonymous_variant	1.0	moxifloxacin
gyrA	8528	c.1227G>C	synonymous_variant	1.0	levofloxacin
gyrA	8528	c.1227G>C	synonymous_variant	1.0	moxifloxacin
gyrA	8543	c.1242C>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8543	c.1242C>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8546	c.1245T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8546	c.1245T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8552	c.1251C>A	synonymous_variant	1.0	levofloxacin
gyrA	8552	c.1251C>A	synonymous_variant	1.0	moxifloxacin
gyrA	8561	c.1260A>G	synonymous_variant	1.0	levofloxacin
gyrA	8561	c.1260A>G	synonymous_variant	1.0	moxifloxacin
gyrA	8576	c.1275C>G	synonymous_variant	1.0	levofloxacin
gyrA	8576	c.1275C>G	synonymous_variant	1.0	moxifloxacin
gyrA	8579	c.1278C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8579	c.1278C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8588	c.1287G>A	synonymous_variant	1.0	levofloxacin
gyrA	8588	c.1287G>A	synonymous_variant	1.0	moxifloxacin
gyrA	8597	c.1296C>G	synonymous_variant	1.0	levofloxacin
gyrA	8597	c.1296C>G	synonymous_variant	1.0	moxifloxacin
gyrA	8603	c.1302A>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8603	c.1302A>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8619	c.1318_1320delTTGinsCA	frameshift_variant&missense_variant	1.0	levofloxacin
gyrA	8619	c.1318_1320delTTGinsCA	frameshift_variant&missense_variant	1.0	moxifloxacin
gyrA	8624	c.1323G>C	synonymous_variant	1.0	levofloxacin
gyrA	8624	c.1323G>C	synonymous_variant	1.0	moxifloxacin
gyrA	8636	c.1335A>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8636	c.1335A>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8642	c.1341A>G	synonymous_variant	1.0	levofloxacin
gyrA	8642	c.1341A>G	synonymous_variant	1.0	moxifloxacin
gyrA	8672	c.1371A>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8672	c.1371A>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8678	c.1377G>A	synonymous_variant	1.0	levofloxacin
gyrA	8678	c.1377G>A	synonymous_variant	1.0	moxifloxacin
gyrA	8693	c.1392T>C	synonymous_variant	1.0	levofloxacin
gyrA	8693	c.1392T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8696	c.1395G>C	synonymous_variant	1.0	levofloxacin
gyrA	8696	c.1395G>C	synonymous_variant	1.0	moxifloxacin
gyrA	8699	c.1398A>G	synonymous_variant	1.0	levofloxacin
gyrA	8699	c.1398A>G	synonymous_variant	1.0	moxifloxacin
gyrA	8711	c.1410A>C	synonymous_variant	1.0	levofloxacin
gyrA	8711	c.1410A>C	synonymous_variant	1.0	moxifloxacin
gyrA	8714	c.1413A>G	synonymous_variant	1.0	levofloxacin
gyrA	8714	c.1413A>G	synonymous_variant	1.0	moxifloxacin
gyrA	8729	c.1428T>C	synonymous_variant	1.0	levofloxacin
gyrA	8729	c.1428T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8730	p.Gly477Arg	missense_variant	1.0	levofloxacin	Uncertain significance
gyrA	8730	p.Gly477Arg	missense_variant	1.0	moxifloxacin
gyrA	8740	p.Arg480His	missense_variant	1.0	levofloxacin
gyrA	8740	p.Arg480His	missense_variant	1.0	moxifloxacin
gyrA	8828	c.1527T>C	synonymous_variant	1.0	levofloxacin
gyrA	8828	c.1527T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8837	c.1536C>T	synonymous_variant	1.0	levofloxacin
gyrA	8837	c.1536C>T	synonymous_variant	1.0	moxifloxacin
gyrA	8852	c.1551T>C	synonymous_variant	1.0	levofloxacin
gyrA	8852	c.1551T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8858	c.1557T>C	synonymous_variant	1.0	levofloxacin
gyrA	8858	c.1557T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8867	c.1566A>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8867	c.1566A>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8870	c.1569G>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8870	c.1569G>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8873	c.1572A>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8873	c.1572A>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8891	c.1590G>A	synonymous_variant	1.0	levofloxacin
gyrA	8891	c.1590G>A	synonymous_variant	1.0	moxifloxacin
gyrA	8897	c.1596T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8897	c.1596T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8933	c.1632G>C	synonymous_variant	1.0	levofloxacin
gyrA	8933	c.1632G>C	synonymous_variant	1.0	moxifloxacin
gyrA	8939	c.1638T>C	synonymous_variant	1.0	levofloxacin
gyrA	8939	c.1638T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8942	c.1641G>C	synonymous_variant	1.0	levofloxacin
gyrA	8942	c.1641G>C	synonymous_variant	1.0	moxifloxacin
gyrA	8946	c.1645_1647delTTGinsCC	frameshift_variant&missense_variant	1.0	levofloxacin
gyrA	8946	c.1645_1647delTTGinsCC	frameshift_variant&missense_variant	1.0	moxifloxacin
gyrA	8966	c.1665C>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8966	c.1665C>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8967	p.Ala556Arg	missense_variant	1.0	levofloxacin
gyrA	8967	p.Ala556Arg	missense_variant	1.0	moxifloxacin
gyrA	8987	c.1686C>G	synonymous_variant	1.0	levofloxacin
gyrA	8987	c.1686C>G	synonymous_variant	1.0	moxifloxacin
gyrA	8990	c.1689C>G	synonymous_variant	1.0	levofloxacin
gyrA	8990	c.1689C>G	synonymous_variant	1.0	moxifloxacin
gyrA	8996	c.1695T>C	synonymous_variant	1.0	levofloxacin
gyrA	8996	c.1695T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8998	p.Leu566Trp	missense_variant	1.0	levofloxacin	Uncertain significance
gyrA	8998	p.Leu566Trp	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	9017	c.1716C>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9017	c.1716C>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9023	c.1722A>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9023	c.1722A>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9089	c.1788G>C	synonymous_variant	1.0	levofloxacin
gyrA	9089	c.1788G>C	synonymous_variant	1.0	moxifloxacin
gyrA	9099	c.1798_1800delTTAinsCG	frameshift_variant&missense_variant	0.93	levofloxacin
gyrA	9099	c.1798_1800delTTAinsCG	frameshift_variant&missense_variant	0.93	moxifloxacin
gyrA	9104	c.1803C>G	synonymous_variant	0.94	levofloxacin	Not assoc w R - Interim
gyrA	9104	c.1803C>G	synonymous_variant	0.94	moxifloxacin	Not assoc w R - Interim
gyrA	9119	c.1818A>G	synonymous_variant	0.94	levofloxacin
gyrA	9119	c.1818A>G	synonymous_variant	0.94	moxifloxacin
gyrA	9122	c.1821C>G	synonymous_variant	0.89	levofloxacin	Not assoc w R - Interim
gyrA	9122	c.1821C>G	synonymous_variant	0.89	moxifloxacin	Not assoc w R - Interim
gyrA	9143	c.1842T>C	synonymous_variant	0.92	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	0.92	moxifloxacin	Not assoc w R
gyrA	9152	c.1851C>T	synonymous_variant	0.91	levofloxacin	Not assoc w R - Interim
gyrA	9152	c.1851C>T	synonymous_variant	0.91	moxifloxacin	Not assoc w R - Interim
gyrA	9153	p.Thr618Glu	missense_variant	0.91	levofloxacin
gyrA	9153	p.Thr618Glu	missense_variant	0.91	moxifloxacin
gyrA	9158	c.1857C>T	synonymous_variant	0.91	levofloxacin	Not assoc w R - Interim
gyrA	9158	c.1857C>T	synonymous_variant	0.91	moxifloxacin	Not assoc w R - Interim
gyrA	9161	c.1860C>G	synonymous_variant	0.91	levofloxacin
gyrA	9161	c.1860C>G	synonymous_variant	0.91	moxifloxacin
gyrA	9182	c.1881T>C	synonymous_variant	0.92	levofloxacin	Not assoc w R - Interim
gyrA	9182	c.1881T>C	synonymous_variant	0.92	moxifloxacin	Not assoc w R - Interim
gyrA	9191	c.1890G>C	synonymous_variant	0.92	levofloxacin
gyrA	9191	c.1890G>C	synonymous_variant	0.92	moxifloxacin
gyrA	9200	c.1899A>G	synonymous_variant	0.92	levofloxacin	Not assoc w R - Interim
gyrA	9200	c.1899A>G	synonymous_variant	0.92	moxifloxacin	Not assoc w R - Interim
gyrA	9204	p.Ser635Thr	missense_variant	0.92	levofloxacin
gyrA	9204	p.Ser635Thr	missense_variant	0.92	moxifloxacin
gyrA	9224	c.1923C>T	synonymous_variant	0.92	levofloxacin
gyrA	9224	c.1923C>T	synonymous_variant	0.92	moxifloxacin
gyrA	9230	c.1929T>C	synonymous_variant	0.93	levofloxacin
gyrA	9230	c.1929T>C	synonymous_variant	0.93	moxifloxacin
gyrA	9233	c.1932C>G	synonymous_variant	0.93	levofloxacin
gyrA	9233	c.1932C>G	synonymous_variant	0.93	moxifloxacin
gyrA	9239	c.1938C>T	synonymous_variant	0.92	levofloxacin	Not assoc w R - Interim
gyrA	9239	c.1938C>T	synonymous_variant	0.92	moxifloxacin	Not assoc w R - Interim
gyrA	9252	p.Val651Ile	missense_variant	0.96	levofloxacin	Uncertain significance
gyrA	9252	p.Val651Ile	missense_variant	0.96	moxifloxacin	Uncertain significance
gyrA	9284	c.1983T>C	synonymous_variant	1.0	levofloxacin
gyrA	9284	c.1983T>C	synonymous_variant	1.0	moxifloxacin
gyrA	9291	c.1990C>T	synonymous_variant	1.0	levofloxacin
gyrA	9291	c.1990C>T	synonymous_variant	1.0	moxifloxacin
gyrA	9296	c.1995T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9296	c.1995T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9299	c.1998G>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9299	c.1998G>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9300	p.Ala667Ser	missense_variant	1.0	levofloxacin
gyrA	9300	p.Ala667Ser	missense_variant	1.0	moxifloxacin
gyrA	9304	p.Gly668Asp	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9308	p.Asp669Glu	missense_variant	1.0	levofloxacin
gyrA	9308	p.Asp669Glu	missense_variant	1.0	moxifloxacin
gyrA	9323	c.2022C>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9323	c.2022C>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9335	c.2034G>C	synonymous_variant	1.0	levofloxacin
gyrA	9335	c.2034G>C	synonymous_variant	1.0	moxifloxacin
gyrA	9365	c.2064G>A	synonymous_variant	1.0	levofloxacin
gyrA	9365	c.2064G>A	synonymous_variant	1.0	moxifloxacin
gyrA	9374	c.2073G>C	synonymous_variant	1.0	levofloxacin
gyrA	9374	c.2073G>C	synonymous_variant	1.0	moxifloxacin
gyrA	9377	c.2076A>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9377	c.2076A>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9383	c.2082T>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9383	c.2082T>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9386	c.2085T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9386	c.2085T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9395	c.2094G>C	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9395	c.2094G>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9398	c.2097T>C	synonymous_variant	1.0	levofloxacin
gyrA	9398	c.2097T>C	synonymous_variant	1.0	moxifloxacin
gyrA	9566	c.2265C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9566	c.2265C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9572	c.2271C>G	synonymous_variant	1.0	levofloxacin
gyrA	9572	c.2271C>G	synonymous_variant	1.0	moxifloxacin
gyrA	9578	c.2277C>T	synonymous_variant	1.0	levofloxacin
gyrA	9578	c.2277C>T	synonymous_variant	1.0	moxifloxacin
gyrA	9582	c.2281A>C	synonymous_variant	1.0	levofloxacin
gyrA	9582	c.2281A>C	synonymous_variant	1.0	moxifloxacin
gyrA	9585	c.2284T>C	synonymous_variant	1.0	levofloxacin
gyrA	9585	c.2284T>C	synonymous_variant	1.0	moxifloxacin
gyrA	9590	c.2289T>C	synonymous_variant	1.0	levofloxacin
gyrA	9590	c.2289T>C	synonymous_variant	1.0	moxifloxacin
gyrA	9593	c.2292G>C	synonymous_variant	1.0	levofloxacin
gyrA	9593	c.2292G>C	synonymous_variant	1.0	moxifloxacin
gyrA	9602	c.2301T>C	synonymous_variant	1.0	levofloxacin
gyrA	9602	c.2301T>C	synonymous_variant	1.0	moxifloxacin
gyrA	9611	p.Asp770Glu	missense_variant	1.0	levofloxacin
gyrA	9611	p.Asp770Glu	missense_variant	1.0	moxifloxacin
gyrA	9626	c.2325T>C	synonymous_variant	1.0	levofloxacin
gyrA	9626	c.2325T>C	synonymous_variant	1.0	moxifloxacin
gyrA	9629	c.2328C>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9629	c.2328C>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9630	p.Val777Ile	missense_variant	1.0	levofloxacin
gyrA	9630	p.Val777Ile	missense_variant	1.0	moxifloxacin
gyrA	9635	c.2334T>C	synonymous_variant	1.0	levofloxacin
gyrA	9635	c.2334T>C	synonymous_variant	1.0	moxifloxacin
gyrA	9638	c.2337C>G	synonymous_variant	1.0	levofloxacin
gyrA	9638	c.2337C>G	synonymous_variant	1.0	moxifloxacin
gyrA	9641	c.2340C>A	synonymous_variant	1.0	levofloxacin
gyrA	9641	c.2340C>A	synonymous_variant	1.0	moxifloxacin
gyrA	9644	c.2343T>C	synonymous_variant	1.0	levofloxacin
gyrA	9644	c.2343T>C	synonymous_variant	1.0	moxifloxacin
gyrA	9650	c.2349G>C	synonymous_variant	1.0	levofloxacin
gyrA	9650	c.2349G>C	synonymous_variant	1.0	moxifloxacin
gyrA	9656	c.2355C>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9656	c.2355C>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9665	c.2364A>C	synonymous_variant	1.0	levofloxacin
gyrA	9665	c.2364A>C	synonymous_variant	1.0	moxifloxacin
gyrA	9666	p.Arg789Gly	missense_variant	1.0	levofloxacin	Uncertain significance
gyrA	9666	p.Arg789Gly	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	9674	c.2373T>C	synonymous_variant	1.0	levofloxacin
gyrA	9674	c.2373T>C	synonymous_variant	1.0	moxifloxacin
gyrA	9704	c.2403T>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9704	c.2403T>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
ccsA	619507	c.-384A>G	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619528	c.-363C>G	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619531	c.-360T>C	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619535	c.-356_-354delCAAinsGCG	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619543	c.-348C>G	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619552	c.-339A>G	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619555	c.-336C>G	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619561	c.-330G>C	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619570	c.-321G>C	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619574	c.-317G>A	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619579	c.-312G>C	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619584	c.-307A>T	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619591	c.-300G>C	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619609	c.-282G>C	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619634	c.-257T>A	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619645	c.-246G>C	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	619654	c.-237A>G	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620265	c.375C>G	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620268	c.378G>C	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620283	c.393T>C	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620284	c.394_396delGCGinsCC	frameshift_variant&missense_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620288	p.Arg133Gln	missense_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620295	c.405G>T	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620298	c.408G>C	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620310	c.420C>T	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620317	c.427_429delGTCinsCG	frameshift_variant&missense_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620340	c.450C>G	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620346	c.456C>G	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620362	p.Ala158Thr	missense_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620367	c.477T>C	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620373	c.483C>G	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620376	c.486G>C	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620385	c.495G>C	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620388	c.498A>G	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620389	c.499C>T	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620412	c.522T>C	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620415	c.525T>C	synonymous_variant	1.0	capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
ccsA	620421	c.531G>C	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620424	c.534G>C	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620433	c.543C>G	synonymous_variant	1.0	capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
ccsA	620436	c.546T>A	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620439	c.549T>C	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620445	c.555A>G	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620583	c.693G>C	synonymous_variant	0.75	capreomycin
					amikacin
					kanamycin
ccsA	620586	c.696C>G	synonymous_variant	0.79	capreomycin
					amikacin
					kanamycin
ccsA	620598	c.708C>G	synonymous_variant	0.81	capreomycin
					amikacin
					kanamycin
ccsA	620601	c.711C>T	synonymous_variant	0.81	capreomycin
					amikacin
					kanamycin
ccsA	620604	c.714C>G	synonymous_variant	0.81	capreomycin
					amikacin
					kanamycin
ccsA	620607	c.717T>C	synonymous_variant	0.76	capreomycin
					amikacin
					kanamycin
ccsA	620613	c.723C>G	synonymous_variant	0.79	capreomycin
					amikacin
					kanamycin
ccsA	620622	c.732G>C	synonymous_variant	0.81	capreomycin
					amikacin
					kanamycin
ccsA	620625	c.735A>C	synonymous_variant	1.0	capreomycin
					amikacin
					kanamycin
ccsA	620631	c.741T>G	synonymous_variant	0.86	capreomycin
					amikacin
					kanamycin
ccsA	620646	c.756G>A	synonymous_variant	0.88	capreomycin
					amikacin
					kanamycin
ccsA	620649	c.759A>G	synonymous_variant	0.88	capreomycin
					amikacin
					kanamycin
ccsA	620659	c.769_771delCGCinsAG	frameshift_variant&missense_variant	0.86	capreomycin
					amikacin
					kanamycin
ccsA	620664	c.774C>T	synonymous_variant	0.86	capreomycin
					amikacin
					kanamycin
ccsA	620682	c.792G>A	synonymous_variant	0.9	capreomycin
					amikacin
					kanamycin
ccsA	620688	c.798G>C	synonymous_variant	0.92	capreomycin
					amikacin
					kanamycin
ccsA	620710	c.820_822delGTGinsAA	frameshift_variant&missense_variant	0.93	capreomycin
					amikacin
					kanamycin
ccsA	620718	c.828G>C	synonymous_variant	0.93	capreomycin
					amikacin
					kanamycin
ccsA	620721	c.831G>C	synonymous_variant	0.93	capreomycin
					amikacin
					kanamycin
ccsA	620733	c.843G>C	synonymous_variant	0.97	capreomycin
					amikacin
					kanamycin
ccsA	620734	c.844C>A	synonymous_variant	0.97	capreomycin
					amikacin
					kanamycin
ccsA	620739	c.849A>G	synonymous_variant	0.92	capreomycin
					amikacin
					kanamycin
ccsA	620742	c.852G>C	synonymous_variant	0.92	capreomycin
					amikacin
					kanamycin
ccsA	620745	c.855G>C	synonymous_variant	0.92	capreomycin
					amikacin
					kanamycin
ccsA	620748	c.858T>A	synonymous_variant	0.92	capreomycin
					amikacin
					kanamycin
ccsA	620763	c.873G>A	synonymous_variant	0.94	capreomycin
					amikacin
					kanamycin
ccsA	620769	c.879C>G	synonymous_variant	0.94	capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
ccsA	620778	c.888T>C	synonymous_variant	0.91	capreomycin
					amikacin
					kanamycin
ccsA	620784	c.894C>G	synonymous_variant	0.91	capreomycin
					amikacin
					kanamycin
ccsA	620790	c.900C>T	synonymous_variant	0.9	capreomycin
					amikacin
					kanamycin
ccsA	620796	c.906C>G	synonymous_variant	0.9	capreomycin
					amikacin
					kanamycin
ccsA	620809	c.919C>T	synonymous_variant	0.94	capreomycin
					amikacin
					kanamycin
Rv0565c	656192	p.Asp427Asn	missense_variant	1.0	ethionamide	Uncertain significance
Rv0565c	656196	p.Leu425Arg	missense_variant	1.0	ethionamide
Rv0565c	656219	p.His418Tyr	missense_variant	0.94	ethionamide
Rv0565c	656220	c.1251A>C	synonymous_variant	0.94	ethionamide
Rv0565c	656223	c.1248T>C	synonymous_variant	0.94	ethionamide	Not assoc w R - Interim
Rv0565c	656226	c.1243_1245delGCCinsTT	frameshift_variant&missense_variant	0.94	ethionamide	Uncertain significance
Rv0565c	656238	p.Ala411Glu	missense_variant	0.89	ethionamide
Rv0565c	656243	p.Leu410Met	missense_variant	0.89	ethionamide
Rv0565c	656244	c.1227A>C	synonymous_variant	0.89	ethionamide
Rv0565c	656265	c.1206G>C	synonymous_variant	0.89	ethionamide
Rv0565c	656268	p.Met401Ile	missense_variant	0.89	ethionamide
Rv0565c	656277	c.1194C>G	synonymous_variant	0.89	ethionamide
Rv0565c	656289	c.1182C>G	synonymous_variant	0.92	ethionamide
Rv0565c	656298	c.1173G>C	synonymous_variant	0.93	ethionamide
Rv0565c	656304	c.1167T>C	synonymous_variant	0.93	ethionamide
Rv0565c	656325	c.1146C>G	synonymous_variant	0.92	ethionamide
Rv0565c	656358	c.1113T>C	synonymous_variant	0.93	ethionamide	Not assoc w R - Interim
Rv0565c	656361	c.1110C>G	synonymous_variant	0.93	ethionamide
Rv0565c	656364	c.1107T>C	synonymous_variant	0.93	ethionamide
Rv0565c	656367	c.1101_1104delTCGGinsGC	frameshift_variant&synonymous_variant	0.93	ethionamide	Uncertain significance
Rv0565c	656371	p.Pro367His	missense_variant	0.93	ethionamide
Rv0565c	656375	c.1095_1096insAA	frameshift_variant	0.88	ethionamide	Uncertain significance
Rv0565c	656383	p.Val363Asn	missense_variant	1.0	ethionamide
Rv0565c	656391	c.1080C>G	synonymous_variant	1.0	ethionamide
Rv0565c	656402	p.Ala357Thr	missense_variant	1.0	ethionamide
Rv0565c	656412	c.1059T>G	synonymous_variant	1.0	ethionamide
Rv0565c	656418	c.1053A>G	synonymous_variant	1.0	ethionamide
Rv0565c	656423	c.1048T>C	synonymous_variant	1.0	ethionamide
Rv0565c	656448	c.1021_1023delATTinsGC	frameshift_variant&missense_variant	1.0	ethionamide	Uncertain significance
Rv0565c	656454	c.1017G>C	synonymous_variant	1.0	ethionamide
Rv0565c	656457	c.1014T>C	synonymous_variant	1.0	ethionamide
Rv0565c	656469	c.1002T>C	synonymous_variant	1.0	ethionamide
Rv0565c	656475	c.996A>G	synonymous_variant	1.0	ethionamide
Rv0565c	656484	c.987T>C	synonymous_variant	1.0	ethionamide
Rv0565c	656487	c.984T>C	synonymous_variant	1.0	ethionamide	Not assoc w R - Interim
Rv0565c	656493	c.978C>G	synonymous_variant	1.0	ethionamide
Rv0565c	656502	c.969C>T	synonymous_variant	1.0	ethionamide
Rv0565c	656511	c.960T>C	synonymous_variant	1.0	ethionamide	Not assoc w R - Interim
Rv0565c	657300	c.171C>G	synonymous_variant	1.0	ethionamide
Rv0565c	657689	c.-220_-219delCAinsAC	upstream_gene_variant	0.83	ethionamide
Rv0565c	657701	c.-231C>G	upstream_gene_variant	0.86	ethionamide
Rv0565c	657734	c.-264T>C	upstream_gene_variant	0.81	ethionamide
nusG	734407	c.154_156delGTTinsAC	frameshift_variant&missense_variant	1.0	rifampicin
nusG	734421	c.168A>G	synonymous_variant	1.0	rifampicin
nusG	734424	c.171G>A	synonymous_variant	1.0	rifampicin
nusG	734442	c.189G>A	synonymous_variant	0.94	rifampicin
nusG	734451	c.198G>C	synonymous_variant	0.94	rifampicin
nusG	734457	c.204C>G	synonymous_variant	0.94	rifampicin
nusG	734472	c.219T>C	synonymous_variant	0.9	rifampicin
nusG	734475	c.222T>C	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
nusG	734499	c.246G>C	synonymous_variant	0.86	rifampicin
nusG	734532	c.279A>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
nusG	734541	c.288A>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	760091	c.285G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760101	c.295T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760112	c.306T>C	synonymous_variant	1.0	rifampicin
rpoB	760118	c.312T>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760121	c.315T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760130	p.Asp108Glu	missense_variant	1.0	rifampicin	Uncertain significance
rpoB	760139	c.333A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760142	c.336C>G	synonymous_variant	1.0	rifampicin
rpoB	760181	c.375T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760184	c.378A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760196	c.390C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760223	c.417T>C	synonymous_variant	1.0	rifampicin
rpoB	760235	c.429T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760283	c.477G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760298	c.492G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760307	c.501T>C	synonymous_variant	1.0	rifampicin
rpoB	760310	c.504G>C	synonymous_variant	1.0	rifampicin
rpoB	760328	c.522G>C	synonymous_variant	1.0	rifampicin
rpoB	760331	c.525G>C	synonymous_variant	1.0	rifampicin
rpoB	760340	c.534G>T	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoB	760361	c.555T>C	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoB	760370	c.564C>G	synonymous_variant	0.93	rifampicin
rpoB	760376	p.Asp190Glu	missense_variant	0.9	rifampicin	Uncertain significance
rpoB	760380	p.Thr192Leu	missense_variant	0.9	rifampicin
rpoB	760406	c.600G>C	synonymous_variant	0.9	rifampicin
rpoB	760412	c.606C>G	synonymous_variant	0.89	rifampicin
rpoB	760424	c.618C>G	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoB	760430	c.624T>C	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoB	760475	c.669A>G	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoB	760481	c.675G>C	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoB	760484	c.678A>G	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoB	760522	p.Ser239Asn	missense_variant	0.94	rifampicin	Uncertain significance
rpoB	760532	c.726T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760533	p.Val243Thr	missense_variant	1.0	rifampicin
rpoB	760541	c.735G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760547	c.741G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760563	p.Arg253Met	missense_variant	1.0	rifampicin	Uncertain significance
rpoB	760591	p.Val262Ala	missense_variant	0.88	rifampicin
rpoB	760611	c.805T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	760646	c.840C>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	760655	c.849A>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	760661	c.855A>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	760670	c.864G>C	synonymous_variant	0.85	rifampicin
rpoB	760674	c.868T>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	760679	c.873A>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	760683	c.877T>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	760715	c.909C>G	synonymous_variant	0.87	rifampicin
rpoB	760718	c.912C>T	synonymous_variant	0.87	rifampicin
rpoB	760724	c.918T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	760730	c.924T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	760751	c.945G>C	synonymous_variant	0.92	rifampicin
rpoB	760757	c.951T>C	synonymous_variant	0.92	rifampicin
rpoB	760759	p.Val318Ala	missense_variant	0.92	rifampicin
rpoB	760769	c.963C>G	synonymous_variant	0.91	rifampicin
rpoB	760775	c.969G>C	synonymous_variant	0.91	rifampicin
rpoB	760776	c.970_972delTCGinsAGC	synonymous_variant	0.91	rifampicin
rpoB	760793	c.987A>G	synonymous_variant	0.85	rifampicin
rpoB	760805	c.999G>C	synonymous_variant	0.83	rifampicin
rpoB	760925	c.1119T>C	synonymous_variant	0.88	rifampicin
rpoB	760928	c.1122G>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	760931	c.1125C>G	synonymous_variant	0.88	rifampicin
rpoB	760934	c.1128C>T	synonymous_variant	0.88	rifampicin
rpoB	760946	c.1140A>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	760982	c.1176G>C	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoB	760985	c.1179G>C	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoB	760991	c.1185G>C	synonymous_variant	0.97	rifampicin
rpoB	761006	c.1200C>G	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoB	761015	c.1209G>C	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoB	761021	c.1215G>C	synonymous_variant	0.96	rifampicin
rpoB	761027	c.1221A>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoB	761036	c.1230G>C	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoB	761037	c.1231T>C	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoB	761057	c.1251G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761102	c.1296A>G	synonymous_variant	1.0	rifampicin
rpoB	761129	c.1323G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761132	c.1326G>T	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	761133	c.1327T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761150	c.1344A>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761153	c.1347G>C	synonymous_variant	1.0	rifampicin
rpoB	761165	c.1359G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761180	c.1374A>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761189	c.1383T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761195	c.1389G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761207	c.1401C>T	synonymous_variant	1.0	rifampicin
rpoB	761213	c.1407G>C	synonymous_variant	1.0	rifampicin
rpoB	761219	c.1413G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761249	c.1443A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761255	c.1449T>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761261	c.1455G>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761531	c.1725C>G	synonymous_variant	1.0	rifampicin
rpoB	761537	c.1731C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761570	c.1764T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761573	c.1767C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761579	c.1773G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761588	c.1782C>T	synonymous_variant	1.0	rifampicin
rpoB	761606	c.1800C>G	synonymous_variant	1.0	rifampicin
rpoB	761612	c.1806G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761615	c.1809A>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761636	c.1830G>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761645	c.1839C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761648	c.1842T>C	synonymous_variant	1.0	rifampicin
rpoB	761657	c.1851C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761675	c.1869G>C	synonymous_variant	1.0	rifampicin
rpoB	761720	c.1914C>G	synonymous_variant	0.93	rifampicin
rpoB	761723	c.1917_1919delAGAinsC	frameshift_variant&missense_variant	0.93	rifampicin
rpoB	761732	c.1926C>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoB	761735	c.1929C>G	synonymous_variant	0.94	rifampicin
rpoB	761747	c.1941G>C	synonymous_variant	0.89	rifampicin
rpoB	761750	c.1944G>C	synonymous_variant	0.89	rifampicin
rpoB	761765	c.1959T>C	synonymous_variant	0.91	rifampicin
rpoB	761772	p.His656Ala	missense_variant	0.91	rifampicin
rpoB	761778	p.Asn658Asp	missense_variant	0.91	rifampicin
rpoB	761791	p.Arg662His	missense_variant	0.91	rifampicin
rpoB	761813	c.2007T>C	synonymous_variant	0.9	rifampicin
rpoB	761815	p.Ala670Glu	missense_variant	0.9	rifampicin
rpoB	761834	c.2028T>C	synonymous_variant	0.91	rifampicin
rpoB	761848	p.Cys681Ser	missense_variant	0.96	rifampicin
rpoB	761852	c.2046C>G	synonymous_variant	0.95	rifampicin
rpoB	761858	c.2052G>C	synonymous_variant	0.92	rifampicin
rpoB	761873	c.2067A>C	synonymous_variant	0.96	rifampicin
rpoB	761885	c.2079T>C	synonymous_variant	0.96	rifampicin
rpoB	761906	c.2100C>A	synonymous_variant	1.0	rifampicin
rpoB	761909	c.2103T>C	synonymous_variant	1.0	rifampicin
rpoB	761912	c.2106T>C	synonymous_variant	1.0	rifampicin
rpoB	761915	p.Asp703Glu	missense_variant	1.0	rifampicin
rpoB	761916	p.Asp704Asn	missense_variant	1.0	rifampicin
rpoB	761948	c.2142G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761954	c.2148C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762008	c.2202C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762014	c.2208C>T	synonymous_variant	1.0	rifampicin
rpoB	762017	c.2211A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762053	c.2247T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762062	c.2256T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762065	c.2259T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762083	c.2277T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762086	c.2280G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762101	c.2295C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762114	p.Ile770Val	missense_variant	1.0	rifampicin	Uncertain significance
rpoB	762131	c.2325C>G	synonymous_variant	1.0	rifampicin
rpoB	762140	c.2334G>C	synonymous_variant	1.0	rifampicin
rpoB	762143	c.2337T>C	synonymous_variant	1.0	rifampicin
rpoB	762149	c.2343G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762167	c.2361T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762170	c.2364C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762185	c.2379G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762233	c.2427G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762246	c.2440C>T	synonymous_variant	1.0	rifampicin
rpoB	762254	c.2448T>G	synonymous_variant	1.0	rifampicin
rpoB	762257	c.2451C>G	synonymous_variant	1.0	rifampicin
rpoB	762284	c.2478G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762293	c.2487T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762449	c.2643C>A	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoC	762467	c.-903C>T	upstream_gene_variant	0.92	rifampicin
rpoB	762488	c.2682G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	762489	p.Val895Gln	missense_variant	0.92	rifampicin
rpoC	762509	c.-861T>G	upstream_gene_variant	1.0	rifampicin
rpoB	762510	c.2704_2706delGCCinsCG	frameshift_variant&missense_variant	1.0	rifampicin
rpoC	762521	c.-849C>T	upstream_gene_variant	1.0	rifampicin
rpoC	762533	c.-837T>C	upstream_gene_variant	1.0	rifampicin
rpoC	762536	c.-834T>C	upstream_gene_variant	1.0	rifampicin
rpoC	762537	c.-833T>C	upstream_gene_variant	1.0	rifampicin
rpoC	762551	c.-819C>G	upstream_gene_variant	1.0	rifampicin
rpoB	762857	c.3051C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762860	c.3054G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762863	c.3057T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	762989	c.-381G>C	upstream_gene_variant	0.93	rifampicin
rpoB	762995	c.3189G>T	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoC	763013	c.-357C>G	upstream_gene_variant	0.89	rifampicin
rpoB	763115	c.3309T>C	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
rpoB	763136	c.3330C>T	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	763148	c.-222G>C	upstream_gene_variant	0.93	rifampicin
rpoC	763158	c.-212C>T	upstream_gene_variant	0.96	rifampicin
rpoB	763166	c.3360A>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	763190	c.-180C>T	upstream_gene_variant	1.0	rifampicin
rpoC	763202	c.-168A>G	upstream_gene_variant	1.0	rifampicin
rpoC	763205	c.-165G>C	upstream_gene_variant	1.0	rifampicin
rpoC	763206	c.-164_-162delAGTinsTCG	upstream_gene_variant	1.0	rifampicin
rpoB	763214	c.3408T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	763226	c.-144A>G	upstream_gene_variant	1.0	rifampicin
rpoB	763227	c.3421C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	763238	c.3432T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	763253	c.-117G>C	upstream_gene_variant	1.0	rifampicin
rpoC	763256	c.-114G>A	upstream_gene_variant	1.0	rifampicin
rpoC	763807	c.438T>C	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	763816	c.447C>G	synonymous_variant	0.87	rifampicin
rpoC	763835	p.Ala156Met	missense_variant	0.87	rifampicin
rpoC	763853	p.Val162Ile	missense_variant	0.87	rifampicin
rpoC	763858	c.489A>G	synonymous_variant	0.86	rifampicin
rpoC	763872	p.Gly168Ala	missense_variant	0.88	rifampicin
rpoC	763876	p.Glu169Asp	missense_variant	0.88	rifampicin
rpoC	763879	c.510A>G	synonymous_variant	0.88	rifampicin
rpoC	763888	c.519G>C	synonymous_variant	0.86	rifampicin
rpoC	763891	c.522G>C	synonymous_variant	0.86	rifampicin
rpoC	763894	c.525A>G	synonymous_variant	0.86	rifampicin
rpoC	763900	c.531G>C	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
rpoC	763945	c.576T>C	synonymous_variant	1.0	rifampicin
rpoC	763987	c.618C>T	synonymous_variant	1.0	rifampicin
rpoC	763991	c.622_624delATCinsCG	frameshift_variant&missense_variant	1.0	rifampicin
rpoC	763996	c.627T>C	synonymous_variant	1.0	rifampicin
rpoC	764002	c.633C>G	synonymous_variant	1.0	rifampicin
rpoC	764005	c.636G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764024	c.655_657delTTGinsCC	frameshift_variant&missense_variant	1.0	rifampicin
rpoC	764032	p.Asp221Glu	missense_variant	1.0	rifampicin
rpoC	764040	p.Ser224Thr	missense_variant	1.0	rifampicin
rpoC	764044	c.675T>C	synonymous_variant	1.0	rifampicin
rpoC	764059	c.690G>T	synonymous_variant	1.0	rifampicin
rpoC	764083	c.714A>G	synonymous_variant	1.0	rifampicin
rpoC	764098	c.729A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764101	c.732C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764102	p.Val245Ile	missense_variant	1.0	rifampicin
rpoC	764112	p.Tyr248Phe	missense_variant	1.0	rifampicin
rpoC	764116	c.747C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764131	c.762T>C	synonymous_variant	1.0	rifampicin
rpoC	764188	c.819A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764195	p.Ser276Ile	missense_variant	1.0	rifampicin
rpoC	764203	c.834G>C	synonymous_variant	1.0	rifampicin
rpoC	764206	c.837T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764215	c.846A>G	synonymous_variant	1.0	rifampicin
rpoC	764236	c.867G>A	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoC	764248	c.879C>G	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoC	764257	c.888G>C	synonymous_variant	0.97	rifampicin
rpoC	764266	c.897T>C	synonymous_variant	0.96	rifampicin
rpoC	764269	c.900G>C	synonymous_variant	0.96	rifampicin
rpoC	764272	c.903G>C	synonymous_variant	0.96	rifampicin
rpoC	764278	c.909A>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	764338	c.969G>A	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	764353	c.984G>C	synonymous_variant	0.9	rifampicin
rpoC	764405	c.1036A>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	764419	c.1050C>G	synonymous_variant	0.93	rifampicin
rpoC	764428	c.1059G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	764431	c.1062G>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	764434	c.1065A>G	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	764446	c.1077T>C	synonymous_variant	0.88	rifampicin
rpoC	764449	c.1080G>C	synonymous_variant	0.88	rifampicin
rpoC	764452	c.1083T>C	synonymous_variant	0.87	rifampicin
rpoC	764458	c.1089G>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	764461	c.1092A>G	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	764489	c.1120C>T	synonymous_variant	0.96	rifampicin
rpoC	764497	c.1128A>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	764510	c.1141C>T	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	764521	c.1152T>C	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	764527	c.1158C>T	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	764536	c.1167G>C	synonymous_variant	0.96	rifampicin
rpoC	764539	c.1170C>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	764548	c.1179G>A	synonymous_variant	0.96	rifampicin
rpoC	764551	c.1182G>C	synonymous_variant	0.96	rifampicin
rpoC	764554	c.1185C>T	synonymous_variant	0.93	rifampicin
rpoC	764560	c.1191T>C	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoC	764566	c.1197C>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	764575	c.1206T>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	764593	c.1224C>T	synonymous_variant	1.0	rifampicin
rpoC	764611	c.1242G>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764650	c.1281G>C	synonymous_variant	1.0	rifampicin
rpoC	764651	c.1282_1284delTCGinsAGC	synonymous_variant	1.0	rifampicin
rpoC	764752	c.1383G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764764	c.1395T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764809	c.1440C>T	synonymous_variant	1.0	rifampicin	Not assoc w R
rpoC	764815	c.1446A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764827	c.1458G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764858	c.1489T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764872	c.1503A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764888	c.1519T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764911	c.1542A>G	synonymous_variant	1.0	rifampicin
rpoC	764932	c.1563C>A	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764948	c.1579T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764968	c.1599T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765529	c.2160C>T	synonymous_variant	1.0	rifampicin
rpoC	765541	c.2172C>G	synonymous_variant	1.0	rifampicin
rpoC	765553	c.2184C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765556	c.2187G>C	synonymous_variant	1.0	rifampicin
rpoC	765559	c.2190G>C	synonymous_variant	1.0	rifampicin
rpoC	765580	c.2211G>C	synonymous_variant	1.0	rifampicin
rpoC	765613	p.His748Gln	missense_variant	1.0	rifampicin
rpoC	765625	c.2256C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765631	p.Asp754Glu	missense_variant	1.0	rifampicin
rpoC	765700	c.2331T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765734	c.2365T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765739	c.2370G>T	synonymous_variant	1.0	rifampicin
rpoC	765751	c.2382C>G	synonymous_variant	1.0	rifampicin
rpoC	765753	p.Asp795Ala	missense_variant	1.0	rifampicin	Uncertain significance
rpoC	765772	c.2403C>G	synonymous_variant	1.0	rifampicin
rpoC	765784	c.2415C>G	synonymous_variant	1.0	rifampicin
rpoC	765787	c.2418C>T	synonymous_variant	1.0	rifampicin
rpoC	765793	c.2424C>G	synonymous_variant	1.0	rifampicin
rpoC	765796	c.2427C>T	synonymous_variant	1.0	rifampicin
rpoC	765811	c.2442T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765814	c.2445A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765826	c.2457T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765835	c.2466C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765850	c.2481G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765883	c.2514C>G	synonymous_variant	1.0	rifampicin
rpoC	765886	c.2517C>G	synonymous_variant	1.0	rifampicin
rpoC	765892	c.2523T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	766363	c.2994G>C	synonymous_variant	1.0	rifampicin
rpoC	766366	c.2997C>G	synonymous_variant	1.0	rifampicin
rpoC	766381	c.3012C>T	synonymous_variant	0.92	rifampicin
rpoC	766384	c.3015A>G	synonymous_variant	1.0	rifampicin
rpoC	766390	c.3021C>T	synonymous_variant	1.0	rifampicin
rpoC	766393	c.3024C>G	synonymous_variant	1.0	rifampicin
rpoC	766408	c.3039C>G	synonymous_variant	1.0	rifampicin
rpoC	766411	c.3042C>G	synonymous_variant	1.0	rifampicin
rpoC	766426	c.3057C>T	synonymous_variant	1.0	rifampicin
rpoC	766447	c.3078T>C	synonymous_variant	1.0	rifampicin
rpoC	766462	c.3093G>C	synonymous_variant	1.0	rifampicin
rpoC	766483	c.3114G>C	synonymous_variant	1.0	rifampicin
rpoC	766484	c.3115_3117delGTAinsAC	frameshift_variant&missense_variant	0.95	rifampicin
rpoC	766492	c.3123T>C	synonymous_variant	1.0	rifampicin
rpoC	766522	c.3153C>G	synonymous_variant	1.0	rifampicin
rpoC	766528	c.3159T>C	synonymous_variant	1.0	rifampicin
rpoC	766531	c.3162G>C	synonymous_variant	1.0	rifampicin
rpoC	766540	p.Asp1057Glu	missense_variant	1.0	rifampicin
rpoC	766549	c.3180G>C	synonymous_variant	1.0	rifampicin
rpoC	766573	c.3204T>C	synonymous_variant	1.0	rifampicin
rpoC	766582	c.3213C>G	synonymous_variant	1.0	rifampicin
rpoC	766583	c.3214_3216delGGTinsAC	frameshift_variant&missense_variant	1.0	rifampicin
rpoC	766591	c.3222A>G	synonymous_variant	1.0	rifampicin
rpoC	766594	c.3225G>C	synonymous_variant	1.0	rifampicin
rpoC	766597	c.3228C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	766607	p.Ile1080Leu	missense_variant	1.0	rifampicin
rpoC	766630	c.3261G>C	synonymous_variant	1.0	rifampicin
rpoC	766657	c.3288A>G	synonymous_variant	1.0	rifampicin
rpoC	766672	c.3303T>C	synonymous_variant	1.0	rifampicin
rpoC	766673	p.Gly1102Asn	missense_variant	1.0	rifampicin
rpoC	766726	c.3357T>C	synonymous_variant	1.0	rifampicin
rpoC	766738	c.3369G>C	synonymous_variant	1.0	rifampicin
rpoC	766765	c.3396A>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	766774	c.3405T>C	synonymous_variant	1.0	rifampicin
rpoC	766801	c.3432C>G	synonymous_variant	0.98	rifampicin
rpoC	766804	c.3435A>G	synonymous_variant	0.98	rifampicin	Not assoc w R - Interim
rpoC	766861	c.3492G>C	synonymous_variant	0.98	rifampicin	Not assoc w R - Interim
rpoC	766864	c.3495G>C	synonymous_variant	0.98	rifampicin
rpoC	766900	c.3531T>C	synonymous_variant	0.96	rifampicin
rpoC	766933	c.3564A>G	synonymous_variant	0.96	rifampicin
rpoC	766945	c.3576A>G	synonymous_variant	0.98	rifampicin	Not assoc w R - Interim
rpoC	766963	c.3594T>C	synonymous_variant	0.98	rifampicin	Not assoc w R - Interim
rpoC	766972	c.3603G>C	synonymous_variant	0.98	rifampicin
rpoC	766996	c.3627C>T	synonymous_variant	0.98	rifampicin	Not assoc w R - Interim
rpoC	767009	c.3640_3642delTCGinsAGC	synonymous_variant	0.98	rifampicin
rpoC	767014	c.3645G>C	synonymous_variant	0.98	rifampicin
rpoC	767033	c.3664_3666delTCGinsAGC	synonymous_variant	1.0	rifampicin
rpoC	767059	c.3690T>G	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoC	767062	c.3693C>A	synonymous_variant	0.97	rifampicin
rpoC	767098	c.3729T>C	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	767119	c.3750A>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	767134	c.3765C>A	synonymous_variant	0.95	rifampicin
rpoC	767158	c.3789T>C	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	767180	p.Ala1271Gln	missense_variant	0.91	rifampicin
rpoC	767191	c.3822C>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	767206	c.3837C>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	767209	c.3840T>C	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	767212	c.3843G>C	synonymous_variant	0.95	rifampicin
rpoC	767221	c.3852C>G	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	767230	c.3861G>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoC	767233	c.3864T>C	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
mmpL5	777133	p.Val450Ile	missense_variant	1.0	clofazimine
mmpL5	777133	p.Val450Ile	missense_variant	1.0	bedaquiline
mmpL5	777158	c.1323C>G	synonymous_variant	1.0	clofazimine
mmpL5	777158	c.1323C>G	synonymous_variant	1.0	bedaquiline
mmpL5	777164	c.1317C>G	synonymous_variant	1.0	clofazimine
mmpL5	777164	c.1317C>G	synonymous_variant	1.0	bedaquiline
mmpL5	777170	c.1311T>C	synonymous_variant	1.0	clofazimine
mmpL5	777170	c.1311T>C	synonymous_variant	1.0	bedaquiline
mmpL5	777176	p.Glu435Asp	missense_variant	1.0	clofazimine
mmpL5	777176	p.Glu435Asp	missense_variant	1.0	bedaquiline
mmpL5	777191	c.1290C>G	synonymous_variant	1.0	clofazimine
mmpL5	777191	c.1290C>G	synonymous_variant	1.0	bedaquiline
mmpL5	777194	c.1287A>G	synonymous_variant	1.0	clofazimine
mmpL5	777194	c.1287A>G	synonymous_variant	1.0	bedaquiline
mmpL5	777206	c.1275A>G	synonymous_variant	1.0	clofazimine
mmpL5	777206	c.1275A>G	synonymous_variant	1.0	bedaquiline
rpsL	781832	c.273T>C	synonymous_variant	1.0	streptomycin
rpsL	781838	c.279G>C	synonymous_variant	1.0	streptomycin
rpsL	781841	c.282C>G	synonymous_variant	1.0	streptomycin
rpsL	781865	c.306G>C	synonymous_variant	1.0	streptomycin
rpsL	781868	c.309T>C	synonymous_variant	1.0	streptomycin
rpsL	781871	c.312G>C	synonymous_variant	1.0	streptomycin
rpsL	781877	c.318T>C	synonymous_variant	1.0	streptomycin
rpsL	781892	c.333A>G	synonymous_variant	1.0	streptomycin
rpsL	781898	c.339A>T	synonymous_variant	1.0	streptomycin
rpsL	781916	c.357T>C	synonymous_variant	1.0	streptomycin
rpsL	781929	p.Gly124Ser	missense_variant	1.0	streptomycin	Uncertain significance
rplC	800516	c.-293G>T	upstream_gene_variant	0.94	linezolid
rplC	800537	c.-272C>T	upstream_gene_variant	0.95	linezolid
rplC	800540	c.-269T>C	upstream_gene_variant	0.96	linezolid
rplC	800546	c.-263T>G	upstream_gene_variant	0.96	linezolid
rplC	800567	c.-242A>G	upstream_gene_variant	0.9	linezolid
rplC	800582	c.-227C>G	upstream_gene_variant	0.91	linezolid
rplC	800612	c.-197A>G	upstream_gene_variant	0.92	linezolid
rplC	800618	c.-191T>C	upstream_gene_variant	0.93	linezolid
rplC	800627	c.-182C>T	upstream_gene_variant	0.93	linezolid
rplC	800648	c.-161A>T	upstream_gene_variant	0.91	linezolid
rplC	800654	c.-155T>C	upstream_gene_variant	0.93	linezolid
rplC	800693	c.-116A>G	upstream_gene_variant	0.93	linezolid
rplC	800703	c.-106T>C	upstream_gene_variant	0.93	linezolid
rplC	800715	c.-94A>C	upstream_gene_variant	0.96	linezolid
rplC	800720	c.-89T>C	upstream_gene_variant	0.98	linezolid
rplC	800723	c.-86C>G	upstream_gene_variant	0.98	linezolid
rplC	800747	c.-62C>G	upstream_gene_variant	0.97	linezolid
rplC	800771	c.-38C>T	upstream_gene_variant	0.97	linezolid
rplC	800794	c.-15A>G	upstream_gene_variant	1.0	linezolid
rplC	800796	c.-13A>G	upstream_gene_variant	1.0	linezolid
rplC	800798	c.-10_-9delGG	upstream_gene_variant	1.0	linezolid
rplC	800814	c.6A>G	synonymous_variant	1.0	linezolid
rplC	800817	c.9A>T	synonymous_variant	1.0	linezolid
rplC	800844	c.36T>C	synonymous_variant	1.0	linezolid
rplC	800865	c.57A>G	synonymous_variant	1.0	linezolid
rplC	800867	p.Ser20Asn	missense_variant	1.0	linezolid
rplC	800874	c.66A>G	synonymous_variant	1.0	linezolid
rplC	800875	c.67_69delGTAinsAT	frameshift_variant&missense_variant	1.0	linezolid
rplC	800880	c.72A>G	synonymous_variant	1.0	linezolid
rplC	800889	c.81C>G	synonymous_variant	1.0	linezolid
rplC	800892	c.84G>C	synonymous_variant	1.0	linezolid
rplC	800907	c.99C>G	synonymous_variant	1.0	linezolid
rplC	800916	c.108A>G	synonymous_variant	1.0	linezolid
rplC	800934	c.126C>G	synonymous_variant	1.0	linezolid
rplC	800937	c.129A>G	synonymous_variant	1.0	linezolid
rplC	800939	p.Arg44Gln	missense_variant	1.0	linezolid
rplC	800946	c.138T>C	synonymous_variant	1.0	linezolid
rplC	800949	c.141T>C	synonymous_variant	1.0	linezolid
rplC	800967	c.159C>G	synonymous_variant	1.0	linezolid
rplC	801300	c.492C>G	synonymous_variant	1.0	linezolid
rplC	801309	c.501C>G	synonymous_variant	1.0	linezolid
rplC	801312	c.504G>C	synonymous_variant	1.0	linezolid
rplC	801321	c.513C>T	synonymous_variant	1.0	linezolid	Not assoc w R - Interim
rplC	801324	c.516T>C	synonymous_variant	1.0	linezolid
rplC	801339	c.531T>C	synonymous_variant	1.0	linezolid
rplC	801341	p.Leu178Gln	missense_variant	1.0	linezolid
rplC	801348	c.540T>G	synonymous_variant	1.0	linezolid
rplC	801357	c.549T>C	synonymous_variant	1.0	linezolid
rplC	801367	p.Ala187Thr	missense_variant	1.0	linezolid
rplC	801402	c.594T>C	synonymous_variant	1.0	linezolid
rplC	801405	c.597T>C	synonymous_variant	1.0	linezolid
rplC	801423	c.615G>C	synonymous_variant	1.0	linezolid
rplC	801426	c.618C>G	synonymous_variant	1.0	linezolid
rplC	801427	p.Met207Val	missense_variant	1.0	linezolid
rplC	801438	c.630T>C	synonymous_variant	1.0	linezolid
rplC	801442	p.Ile212Val	missense_variant	1.0	linezolid
fbiC	1303632	c.702T>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303641	c.711C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303650	c.720G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303654	c.724C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303659	c.729T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303661	p.Val244Ala	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303663	c.733C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303671	c.741C>T	synonymous_variant	1.0	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid
fbiC	1303674	c.744C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303681	c.751T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303686	c.756C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303695	c.765T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303704	c.774T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303708	c.778T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303728	c.798G>A	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303731	c.801A>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303732	p.Ser268Ala	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303737	c.807G>A	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303746	c.816T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303749	c.819G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303752	c.822A>G	synonymous_variant	1.0	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1303755	c.825T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303761	c.831T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303785	c.855G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303797	c.867A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303818	c.888C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303836	c.906G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303845	c.915C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303846	p.Phe306Val	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303854	c.924T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303860	c.930A>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303884	c.954T>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303905	c.975G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303914	c.984C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303920	c.990C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303944	c.1014G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303947	c.1017T>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303948	p.Gly340Arg	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303953	p.Asp341Glu	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303956	c.1026A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303961	p.Arg344Leu	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303971	c.1041T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1303980	c.1050G>A	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304004	c.1074A>G	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiC	1304008	c.1078T>C	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiC	1304022	c.1092T>C	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiC	1304031	c.1101C>G	synonymous_variant	0.91	clofazimine
					pretomanid
					delamanid
fbiC	1304034	c.1104A>G	synonymous_variant	0.91	clofazimine
					pretomanid
					delamanid
fbiC	1304040	c.1110C>G	synonymous_variant	0.83	clofazimine
					pretomanid
					delamanid
fbiC	1304046	c.1116C>G	synonymous_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiC	1304049	c.1119T>C	synonymous_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiC	1304050	c.1120T>C	synonymous_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiC	1304058	c.1128G>A	synonymous_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiC	1304059	c.1129C>T	synonymous_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiC	1304064	c.1134G>C	synonymous_variant	0.85	clofazimine
					pretomanid
					delamanid
fbiC	1304067	c.1137G>C	synonymous_variant	0.85	clofazimine
					pretomanid
					delamanid
fbiC	1304085	c.1155C>T	synonymous_variant	0.86	clofazimine
					pretomanid
					delamanid
fbiC	1304091	p.Asp387Glu	missense_variant	0.86	clofazimine
					pretomanid
					delamanid
fbiC	1304092	p.Met388Leu	missense_variant	0.86	clofazimine
					pretomanid
					delamanid
fbiC	1304097	c.1167G>C	synonymous_variant	0.88	clofazimine
					pretomanid
					delamanid
fbiC	1304127	c.1197A>G	synonymous_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiC	1304132	p.Ala401Gly	missense_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiC	1304142	c.1212G>C	synonymous_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiC	1304161	p.Arg411Ser	missense_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304169	c.1239T>C	synonymous_variant	0.75	clofazimine
					pretomanid
					delamanid
fbiC	1304174	p.Val415Ala	missense_variant	0.69	clofazimine
					pretomanid
					delamanid
fbiC	1304184	c.1254G>C	synonymous_variant	0.69	clofazimine
					pretomanid
					delamanid
fbiC	1304187	c.1257T>C	synonymous_variant	0.75	clofazimine
					pretomanid
					delamanid
fbiC	1304208	c.1278C>T	synonymous_variant	0.67	clofazimine
					pretomanid
					delamanid
fbiC	1304499	c.1569T>C	synonymous_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1304511	c.1581C>G	synonymous_variant	0.79	clofazimine
					pretomanid
					delamanid
fbiC	1304526	c.1596T>G	synonymous_variant	0.88	clofazimine
					pretomanid
					delamanid
fbiC	1304535	c.1605G>A	synonymous_variant	0.91	clofazimine
					pretomanid
					delamanid
fbiC	1304544	c.1614T>C	synonymous_variant	0.91	clofazimine
					pretomanid
					delamanid
fbiC	1304545	p.Val539Thr	missense_variant	0.91	clofazimine
					pretomanid
					delamanid
fbiC	1304553	c.1623C>T	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiC	1304559	p.Glu543Asp	missense_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiC	1304565	c.1635C>G	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiC	1304568	c.1638T>C	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiC	1304580	c.1650T>C	synonymous_variant	0.96	clofazimine
					pretomanid
					delamanid
fbiC	1304613	c.1683T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304634	c.1704C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304640	c.1710A>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304646	c.1716T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304658	c.1728C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304661	c.1731C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304670	c.1740G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304671	p.Val581Thr	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304675	p.Gly582Asp	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304691	c.1761G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304694	c.1764A>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304703	c.1773C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304711	p.Ala594Glu	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304715	c.1785G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304724	c.1794A>G	synonymous_variant	1.0	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304727	c.1797A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304742	c.1812T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304748	c.1818T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304757	c.1827A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304778	c.1848T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304784	c.1854T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304787	c.1857T>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304808	c.1878C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304811	c.1881C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304817	c.1887T>C	synonymous_variant	0.97	clofazimine
					pretomanid
					delamanid
fbiC	1304829	c.1899T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304832	c.1902C>T	synonymous_variant	1.0	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304853	c.1923C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304856	c.1926C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304869	c.1939C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304875	p.Ile649Val	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304883	p.Glu651Asp	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304891	p.Ile654Thr	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304893	p.Gly655Ser	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304907	c.1977C>G	synonymous_variant	0.97	clofazimine
					pretomanid
					delamanid
fbiC	1304910	c.1980G>C	synonymous_variant	0.97	clofazimine
					pretomanid
					delamanid
fbiC	1304916	c.1986T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304928	c.1998T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304937	c.2007G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304958	c.2028T>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304983	c.2053C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304994	c.2064A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1304995	p.Leu689Met	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305006	c.2076A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305012	c.2082G>C	synonymous_variant	0.97	clofazimine
					pretomanid
					delamanid
fbiC	1305015	c.2085G>C	synonymous_variant	0.97	clofazimine
					pretomanid
					delamanid
fbiC	1305021	c.2091C>G	synonymous_variant	0.97	clofazimine
					pretomanid
					delamanid
fbiC	1305030	c.2100G>C	synonymous_variant	0.95	clofazimine
					pretomanid
					delamanid
fbiC	1305033	c.2103T>G	synonymous_variant	0.95	clofazimine
					pretomanid
					delamanid
fbiC	1305042	c.2112A>G	synonymous_variant	0.95	clofazimine
					pretomanid
					delamanid
fbiC	1305063	c.2133G>C	synonymous_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiC	1305066	c.2136T>C	synonymous_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiC	1305069	c.2139G>C	synonymous_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiC	1305075	c.2145T>C	synonymous_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiC	1305078	c.2148A>G	synonymous_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiC	1305081	c.2151G>C	synonymous_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiC	1305090	c.2160C>G	synonymous_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiC	1305092	p.Ala721Gly	missense_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiC	1305099	c.2169T>C	synonymous_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiC	1305114	c.2184T>C	synonymous_variant	0.93	clofazimine
					pretomanid
					delamanid
fbiC	1305117	c.2187T>C	synonymous_variant	0.93	clofazimine
					pretomanid
					delamanid
fbiC	1305126	c.2196T>C	synonymous_variant	0.94	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1305135	c.2205C>T	synonymous_variant	0.93	clofazimine
					pretomanid
					delamanid
fbiC	1305150	c.2220C>G	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiC	1305173	p.Asn748Ser	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305177	c.2247A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305181	c.2251T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305186	c.2256C>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305195	c.2265T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305201	c.2271G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305204	c.2274C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305210	c.2280G>A	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305215	p.Ser762Thr	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305231	c.2301C>A	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305234	c.2304G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305240	c.2310T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305243	c.2313T>G	synonymous_variant	1.0	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid
fbiC	1305244	c.2314T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305252	c.2322G>A	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305276	c.2346G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305279	p.His783Gln	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305282	c.2352T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305297	c.2367G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305300	c.2370A>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305303	c.2373T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305306	c.2376A>T	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305309	c.2379G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305310	p.Arg794Glu	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305318	c.2388C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305336	c.2406T>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305372	c.2442G>A	synonymous_variant	1.0	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid
fbiC	1305384	c.2454G>C	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
fbiC	1305396	c.2466C>G	synonymous_variant	1.0	clofazimine
					pretomanid
					delamanid
sigE	1364820	c.408A>G	synonymous_variant	0.81	pyrazinamide
sigE	1364839	c.427_429delTTGinsCC	frameshift_variant&missense_variant	0.8	pyrazinamide	Uncertain significance
sigE	1364847	c.435G>C	synonymous_variant	0.86	pyrazinamide
sigE	1364856	c.444C>G	synonymous_variant	0.85	pyrazinamide
sigE	1364862	c.450C>A	synonymous_variant	0.85	pyrazinamide
sigE	1364865	c.453G>C	synonymous_variant	0.85	pyrazinamide
sigE	1364868	c.456T>G	synonymous_variant	0.85	pyrazinamide
sigE	1364887	c.475_477delTTAinsCG	frameshift_variant&missense_variant	0.83	pyrazinamide	Uncertain significance
sigE	1364898	c.486C>T	synonymous_variant	0.82	pyrazinamide
sigE	1364904	p.Asp164Glu	missense_variant	0.82	pyrazinamide
sigE	1364919	c.507T>C	synonymous_variant	0.93	pyrazinamide
sigE	1364943	c.531C>T	synonymous_variant	1.0	pyrazinamide
sigE	1364949	c.537C>T	synonymous_variant	1.0	pyrazinamide
sigE	1364950	p.Ala180Ser	missense_variant	1.0	pyrazinamide
sigE	1365000	c.588G>A	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
sigE	1365006	c.594T>C	synonymous_variant	1.0	pyrazinamide
sigE	1365009	c.597C>G	synonymous_variant	1.0	pyrazinamide
sigE	1365012	c.600G>C	synonymous_variant	1.0	pyrazinamide
sigE	1365015	c.603G>C	synonymous_variant	1.0	pyrazinamide
sigE	1365018	c.606G>C	synonymous_variant	1.0	pyrazinamide
sigE	1365024	c.612T>C	synonymous_variant	1.0	pyrazinamide
sigE	1365033	c.621G>A	synonymous_variant	1.0	pyrazinamide
sigE	1365036	c.624T>C	synonymous_variant	1.0	pyrazinamide
sigE	1365042	c.630G>C	synonymous_variant	1.0	pyrazinamide
atpE	1461113	c.69C>T	synonymous_variant	1.0	bedaquiline
atpE	1461132	p.Val30Ile	missense_variant	1.0	bedaquiline
atpE	1461149	c.105T>G	synonymous_variant	1.0	bedaquiline
atpE	1461150	c.106_108delATCinsGT	frameshift_variant&missense_variant	1.0	bedaquiline
atpE	1461158	c.114T>G	synonymous_variant	1.0	bedaquiline
atpE	1461159	p.Val39Ile	missense_variant	1.0	bedaquiline	Uncertain significance
atpE	1461170	c.126A>G	synonymous_variant	1.0	bedaquiline
atpE	1461185	c.141G>T	synonymous_variant	1.0	bedaquiline
atpE	1461197	c.153A>G	synonymous_variant	1.0	bedaquiline
atpE	1461219	c.175T>C	synonymous_variant	1.0	bedaquiline
atpE	1461233	c.189A>C	synonymous_variant	0.92	bedaquiline
rrs	1471934	n.89A>G	non_coding_transcript_exon_variant	0.87	streptomycin	Uncertain significance
					kanamycin
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471969	n.124T>C	non_coding_transcript_exon_variant	0.94	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471970	n.125G>A	non_coding_transcript_exon_variant	0.94	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472028	n.183A>T	non_coding_transcript_exon_variant	0.98	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472029	n.184C>T	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472030	n.185G>T	non_coding_transcript_exon_variant	0.93	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472031	n.186G>A	non_coding_transcript_exon_variant	0.93	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472033	n.188A>G	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472034	n.189T>C	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472044	n.199G>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472045	n.200T>A	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472053	n.211_212delGC	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472061	n.216A>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472075	n.230A>G	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472108	n.263C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472969	n.1124A>G	non_coding_transcript_exon_variant	0.97	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472970	n.1125C>G	non_coding_transcript_exon_variant	0.97	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472977	n.1132G>C	non_coding_transcript_exon_variant	0.97	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472978	n.1133T>C	non_coding_transcript_exon_variant	0.97	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473105	n.1260G>A	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473123	n.1278delAinsTT	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	0.88	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1473668	n.11C>T	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1473668	n.11C>T	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1473756	n.99G>A	non_coding_transcript_exon_variant	0.95	capreomycin
rrl	1473756	n.99G>A	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	0.98	capreomycin	Uncertain significance
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	0.98	linezolid	Uncertain significance
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1473943	n.286G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473943	n.286G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473945	n.288T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473945	n.288T>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473946	n.289A>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473946	n.289A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473986	n.329T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473986	n.329T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473987	n.330G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473987	n.330G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	1.0	linezolid	Not assoc w R
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474012	n.355C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474012	n.355C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474093	n.436G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474093	n.436G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474099	n.442G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474099	n.442G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474291	n.635_649delTTCCTCTCCGGAGGA	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1474291	n.635_649delTTCCTCTCCGGAGGA	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1474310	n.653T>G	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1474310	n.653T>G	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1474356	n.699T>C	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1474356	n.699T>C	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1474362	n.705A>G	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1474362	n.705A>G	non_coding_transcript_exon_variant	0.91	linezolid	Uncertain significance
rrl	1474376	n.719T>C	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1474376	n.719T>C	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1474409	n.756_766delACCCACACGCG	non_coding_transcript_exon_variant	0.93	capreomycin
rrl	1474409	n.756_766delACCCACACGCG	non_coding_transcript_exon_variant	0.93	linezolid
rrl	1474427	n.770A>C	non_coding_transcript_exon_variant	0.93	capreomycin
rrl	1474427	n.770A>C	non_coding_transcript_exon_variant	0.93	linezolid
rrl	1474429	n.772G>C	non_coding_transcript_exon_variant	0.93	capreomycin
rrl	1474429	n.772G>C	non_coding_transcript_exon_variant	0.93	linezolid
rrl	1474431	n.774_775delGCinsTTTGGG	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1474431	n.774_775delGCinsTTTGGG	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1474435	n.780_783delGAAT	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1474435	n.780_783delGAAT	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1474639	n.982G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474639	n.982G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474823	n.1166C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474823	n.1166C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474904	n.1247G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474904	n.1247G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474956	n.1299C>T	non_coding_transcript_exon_variant	0.97	capreomycin
rrl	1474956	n.1299C>T	non_coding_transcript_exon_variant	0.97	linezolid
rrl	1474960	n.1303C>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474960	n.1303C>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474963	n.1306G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474963	n.1306G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474964	n.1307T>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474964	n.1307T>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474965	n.1308G>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474965	n.1308G>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474970	n.1313G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474970	n.1313G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475006	n.1349A>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475006	n.1349A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475061	n.1404C>T	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1475061	n.1404C>T	non_coding_transcript_exon_variant	0.97	linezolid
rrl	1475088	n.1431A>T	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1475088	n.1431A>T	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475199	n.1542G>A	non_coding_transcript_exon_variant	0.97	capreomycin
rrl	1475199	n.1542G>A	non_coding_transcript_exon_variant	0.97	linezolid
rrl	1475206	n.1549C>T	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1475206	n.1549C>T	non_coding_transcript_exon_variant	0.97	linezolid
rrl	1475209	n.1552G>C	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475209	n.1552G>C	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475213	n.1556C>T	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1475213	n.1556C>T	non_coding_transcript_exon_variant	0.97	linezolid
rrl	1475249	n.1592T>C	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1475249	n.1592T>C	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1475252	n.1595C>T	non_coding_transcript_exon_variant	0.97	capreomycin
rrl	1475252	n.1595C>T	non_coding_transcript_exon_variant	0.97	linezolid
rrl	1475266	n.1609T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475266	n.1609T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475267	n.1610G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475267	n.1610G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475275	n.1618C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475275	n.1618C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475276	n.1619T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475276	n.1619T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475291	n.1634A>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475291	n.1634A>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475402	n.1745C>T	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1475402	n.1745C>T	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1475436	n.1779C>T	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1475436	n.1779C>T	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475659	n.2002G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475659	n.2002G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475761	n.2104_2106delCGCinsGT	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475761	n.2104_2106delCGCinsGT	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475765	n.2111delG	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475765	n.2111delG	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476031	n.2374C>T	non_coding_transcript_exon_variant	0.93	capreomycin
rrl	1476031	n.2374C>T	non_coding_transcript_exon_variant	0.93	linezolid
rrl	1476032	n.2375C>A	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1476032	n.2375C>A	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476034	n.2377C>A	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476034	n.2377C>A	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476047	n.2390G>T	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1476047	n.2390G>T	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476048	n.2391G>A	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1476048	n.2391G>A	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476214	n.2557G>A	non_coding_transcript_exon_variant	0.96	capreomycin
rrl	1476214	n.2557G>A	non_coding_transcript_exon_variant	0.96	linezolid
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476594	n.2937C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476594	n.2937C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476603	n.2946G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476603	n.2946G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476689	n.3032A>T	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1476689	n.3032A>T	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1476690	n.3033C>T	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1476690	n.3033C>T	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1476693	n.3036G>A	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1476693	n.3036G>A	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1476695	n.3038T>A	non_coding_transcript_exon_variant	0.94	capreomycin
rrl	1476695	n.3038T>A	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1476716	n.3059A>C	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1476716	n.3059A>C	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1476726	n.3069A>G	non_coding_transcript_exon_variant	0.89	capreomycin
rrl	1476726	n.3069A>G	non_coding_transcript_exon_variant	0.89	linezolid
rrl	1476732	n.3075T>C	non_coding_transcript_exon_variant	0.89	capreomycin
rrl	1476732	n.3075T>C	non_coding_transcript_exon_variant	0.89	linezolid
rrl	1476750	n.3093T>C	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1476750	n.3093T>C	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1476755	n.3098G>A	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1476755	n.3098G>A	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1476759	n.3102T>C	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1476759	n.3102T>C	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1476770	n.3113T>C	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1476770	n.3113T>C	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1476771	n.3114G>A	non_coding_transcript_exon_variant	0.77	capreomycin
rrl	1476771	n.3114G>A	non_coding_transcript_exon_variant	0.77	linezolid
inhA	1673547	c.-655T>C	upstream_gene_variant	1.0	ethionamide
inhA	1673547	c.-655T>C	upstream_gene_variant	1.0	isoniazid
inhA	1673568	c.-634C>G	upstream_gene_variant	1.0	ethionamide
inhA	1673568	c.-634C>G	upstream_gene_variant	1.0	isoniazid
inhA	1673574	c.-628C>G	upstream_gene_variant	1.0	ethionamide
inhA	1673574	c.-628C>G	upstream_gene_variant	1.0	isoniazid
inhA	1673580	c.-622T>G	upstream_gene_variant	1.0	ethionamide
inhA	1673580	c.-622T>G	upstream_gene_variant	1.0	isoniazid	Uncertain significance
inhA	1673589	c.-613A>G	upstream_gene_variant	1.0	ethionamide
inhA	1673589	c.-613A>G	upstream_gene_variant	1.0	isoniazid
inhA	1673595	c.-607A>C	upstream_gene_variant	1.0	ethionamide
inhA	1673595	c.-607A>C	upstream_gene_variant	1.0	isoniazid
fabG1	1673596	p.Lys53Glu	missense_variant	1.0	ethionamide
fabG1	1673596	p.Lys53Glu	missense_variant	1.0	isoniazid
inhA	1673602	c.-600C>T	upstream_gene_variant	1.0	ethionamide
inhA	1673602	c.-600C>T	upstream_gene_variant	1.0	isoniazid
inhA	1673607	c.-595T>C	upstream_gene_variant	1.0	ethionamide
inhA	1673607	c.-595T>C	upstream_gene_variant	1.0	isoniazid
fabG1	1673615	p.Glu59Val	missense_variant	1.0	ethionamide
fabG1	1673615	p.Glu59Val	missense_variant	1.0	isoniazid
inhA	1673619	c.-583T>C	upstream_gene_variant	1.0	ethionamide
inhA	1673619	c.-583T>C	upstream_gene_variant	1.0	isoniazid
fabG1	1673633	p.Ser65Asn	missense_variant	1.0	ethionamide
fabG1	1673633	p.Ser65Asn	missense_variant	1.0	isoniazid
fabG1	1673637	p.Asp66Glu	missense_variant	1.0	ethionamide
fabG1	1673637	p.Asp66Glu	missense_variant	1.0	isoniazid
fabG1	1673641	p.Val68Ile	missense_variant	1.0	ethionamide
fabG1	1673641	p.Val68Ile	missense_variant	1.0	isoniazid
inhA	1673646	c.-556T>C	upstream_gene_variant	1.0	ethionamide
inhA	1673646	c.-556T>C	upstream_gene_variant	1.0	isoniazid
inhA	1673652	c.-550C>G	upstream_gene_variant	1.0	ethionamide
inhA	1673652	c.-550C>G	upstream_gene_variant	1.0	isoniazid
fabG1	1673657	p.Thr73Lys	missense_variant	1.0	ethionamide
fabG1	1673657	p.Thr73Lys	missense_variant	1.0	isoniazid
fabG1	1673660	p.Ala74Glu	missense_variant	1.0	ethionamide
fabG1	1673660	p.Ala74Glu	missense_variant	1.0	isoniazid
inhA	1673664	c.-538A>C	upstream_gene_variant	1.0	ethionamide
inhA	1673664	c.-538A>C	upstream_gene_variant	1.0	isoniazid
inhA	1673667	c.-535A>G	upstream_gene_variant	1.0	ethionamide
inhA	1673667	c.-535A>G	upstream_gene_variant	1.0	isoniazid
inhA	1673679	c.-523T>C	upstream_gene_variant	1.0	ethionamide	Uncertain significance
inhA	1673679	c.-523T>C	upstream_gene_variant	1.0	isoniazid	Uncertain significance
inhA	1673685	c.-517C>T	upstream_gene_variant	1.0	ethionamide
inhA	1673685	c.-517C>T	upstream_gene_variant	1.0	isoniazid
fabG1	1673797	c.358_360delGCTinsAC	frameshift_variant&missense_variant	1.0	ethionamide
fabG1	1673797	c.358_360delGCTinsAC	frameshift_variant&missense_variant	1.0	isoniazid
inhA	1673802	c.-400A>G	upstream_gene_variant	1.0	ethionamide
inhA	1673802	c.-400A>G	upstream_gene_variant	1.0	isoniazid
inhA	1673805	c.-397G>C	upstream_gene_variant	1.0	ethionamide
inhA	1673805	c.-397G>C	upstream_gene_variant	1.0	isoniazid
inhA	1673808	c.-394A>C	upstream_gene_variant	1.0	ethionamide
inhA	1673808	c.-394A>C	upstream_gene_variant	1.0	isoniazid
fabG1	1673809	p.Ser124Ala	missense_variant	1.0	ethionamide
fabG1	1673809	p.Ser124Ala	missense_variant	1.0	isoniazid
fabG1	1673823	c.385_388delCGCA	frameshift_variant	0.92	ethionamide
fabG1	1673823	c.385_388delCGCA	frameshift_variant	0.92	isoniazid
fabG1	1673829	p.Asn130Lys	missense_variant	0.92	ethionamide
fabG1	1673829	p.Asn130Lys	missense_variant	0.92	isoniazid
fabG1	1673832	c.393_394insGCGG	frameshift_variant	0.86	ethionamide
fabG1	1673832	c.393_394insGCGG	frameshift_variant	0.86	isoniazid
inhA	1673838	c.-364T>C	upstream_gene_variant	0.86	ethionamide
inhA	1673838	c.-364T>C	upstream_gene_variant	0.86	isoniazid
inhA	1673841	c.-361A>C	upstream_gene_variant	0.86	ethionamide
inhA	1673841	c.-361A>C	upstream_gene_variant	0.86	isoniazid
fabG1	1673844	p.Met135Ile	missense_variant	0.86	ethionamide
fabG1	1673844	p.Met135Ile	missense_variant	0.86	isoniazid
inhA	1673847	c.-355A>C	upstream_gene_variant	0.86	ethionamide
inhA	1673847	c.-355A>C	upstream_gene_variant	0.86	isoniazid
fabG1	1673849	p.Phe137Tyr	missense_variant	0.86	ethionamide
fabG1	1673849	p.Phe137Tyr	missense_variant	0.86	isoniazid
inhA	1673853	c.-349A>C	upstream_gene_variant	0.86	ethionamide
inhA	1673853	c.-349A>C	upstream_gene_variant	0.86	isoniazid
inhA	1673856	c.-346T>C	upstream_gene_variant	0.87	ethionamide
inhA	1673856	c.-346T>C	upstream_gene_variant	0.87	isoniazid
fabG1	1673890	p.Ala151Ser	missense_variant	0.81	ethionamide
fabG1	1673890	p.Ala151Ser	missense_variant	0.81	isoniazid
inhA	1673901	c.-301A>G	upstream_gene_variant	0.75	ethionamide
inhA	1673901	c.-301A>G	upstream_gene_variant	0.75	isoniazid
fabG1	1673905	p.Ser156Ala	missense_variant	0.73	ethionamide
fabG1	1673905	p.Ser156Ala	missense_variant	0.73	isoniazid
fabG1	1673941	p.Ala168Ser	missense_variant	0.69	ethionamide
fabG1	1673941	p.Ala168Ser	missense_variant	0.69	isoniazid
inhA	1673955	c.-247G>C	upstream_gene_variant	0.79	ethionamide
inhA	1673955	c.-247G>C	upstream_gene_variant	0.79	isoniazid
inhA	1673961	c.-241A>C	upstream_gene_variant	0.82	ethionamide
inhA	1673961	c.-241A>C	upstream_gene_variant	0.82	isoniazid
inhA	1673985	c.-217C>G	upstream_gene_variant	0.91	ethionamide
inhA	1673985	c.-217C>G	upstream_gene_variant	0.91	isoniazid
fabG1	1674006	p.Asp189Glu	missense_variant	0.92	ethionamide
fabG1	1674006	p.Asp189Glu	missense_variant	0.92	isoniazid
inhA	1674015	c.-187C>T	upstream_gene_variant	0.91	ethionamide
inhA	1674015	c.-187C>T	upstream_gene_variant	0.91	isoniazid	Uncertain significance
inhA	1674018	c.-184G>C	upstream_gene_variant	0.91	ethionamide
inhA	1674018	c.-184G>C	upstream_gene_variant	0.91	isoniazid
inhA	1674021	c.-181G>C	upstream_gene_variant	0.91	ethionamide
inhA	1674021	c.-181G>C	upstream_gene_variant	0.91	isoniazid
inhA	1674024	c.-178T>C	upstream_gene_variant	0.91	ethionamide
inhA	1674024	c.-178T>C	upstream_gene_variant	0.91	isoniazid
inhA	1674033	c.-169T>C	upstream_gene_variant	1.0	ethionamide
inhA	1674033	c.-169T>C	upstream_gene_variant	1.0	isoniazid
fabG1	1674037	p.Gln200Ala	missense_variant	1.0	ethionamide
fabG1	1674037	p.Gln200Ala	missense_variant	1.0	isoniazid
inhA	1674042	c.-160G>T	upstream_gene_variant	1.0	ethionamide
inhA	1674042	c.-160G>T	upstream_gene_variant	1.0	isoniazid
fabG1	1674049	c.610_612delCAAinsGC	frameshift_variant&missense_variant	1.0	ethionamide
fabG1	1674049	c.610_612delCAAinsGC	frameshift_variant&missense_variant	1.0	isoniazid
inhA	1674054	c.-148T>C	upstream_gene_variant	1.0	ethionamide
inhA	1674054	c.-148T>C	upstream_gene_variant	1.0	isoniazid
inhA	1674060	c.-142A>G	upstream_gene_variant	1.0	ethionamide
inhA	1674060	c.-142A>G	upstream_gene_variant	1.0	isoniazid
inhA	1674063	c.-139G>C	upstream_gene_variant	1.0	ethionamide
inhA	1674063	c.-139G>C	upstream_gene_variant	1.0	isoniazid
fabG1	1674079	p.Pro214Ala	missense_variant	1.0	ethionamide
fabG1	1674079	p.Pro214Ala	missense_variant	1.0	isoniazid
inhA	1674504	c.303C>G	synonymous_variant	0.92	ethionamide
inhA	1674504	c.303C>G	synonymous_variant	0.92	isoniazid
inhA	1674537	c.336C>G	synonymous_variant	0.96	ethionamide
inhA	1674537	c.336C>G	synonymous_variant	0.96	isoniazid
inhA	1674542	p.Ala114Glu	missense_variant	0.96	ethionamide
inhA	1674542	p.Ala114Glu	missense_variant	0.96	isoniazid
inhA	1674546	c.345T>C	synonymous_variant	0.96	ethionamide
inhA	1674546	c.345T>C	synonymous_variant	0.96	isoniazid
inhA	1674549	c.348G>C	synonymous_variant	0.96	ethionamide
inhA	1674549	c.348G>C	synonymous_variant	0.96	isoniazid
inhA	1674552	c.351C>G	synonymous_variant	0.96	ethionamide
inhA	1674552	c.351C>G	synonymous_variant	0.96	isoniazid
inhA	1674555	c.354G>A	synonymous_variant	1.0	ethionamide	Not assoc w R - Interim
inhA	1674555	c.354G>A	synonymous_variant	1.0	isoniazid	Not assoc w R - Interim
inhA	1674561	c.360C>T	synonymous_variant	1.0	ethionamide
inhA	1674561	c.360C>T	synonymous_variant	1.0	isoniazid
inhA	1674582	c.381T>C	synonymous_variant	1.0	ethionamide
inhA	1674582	c.381T>C	synonymous_variant	1.0	isoniazid
inhA	1674585	c.384T>C	synonymous_variant	1.0	ethionamide
inhA	1674585	c.384T>C	synonymous_variant	1.0	isoniazid
inhA	1674589	p.Met130Leu	missense_variant	1.0	ethionamide
inhA	1674589	p.Met130Leu	missense_variant	1.0	isoniazid
inhA	1674601	p.Leu134Thr	missense_variant	1.0	ethionamide
inhA	1674601	p.Leu134Thr	missense_variant	1.0	isoniazid
inhA	1674624	c.423A>C	synonymous_variant	1.0	ethionamide
inhA	1674624	c.423A>C	synonymous_variant	1.0	isoniazid
inhA	1674630	c.429C>G	synonymous_variant	1.0	ethionamide
inhA	1674630	c.429C>G	synonymous_variant	1.0	isoniazid
inhA	1674660	c.459G>C	synonymous_variant	1.0	ethionamide
inhA	1674660	c.459G>C	synonymous_variant	1.0	isoniazid
inhA	1674672	c.471C>G	synonymous_variant	1.0	ethionamide
inhA	1674672	c.471C>G	synonymous_variant	1.0	isoniazid
inhA	1674703	c.502T>C	synonymous_variant	1.0	ethionamide
inhA	1674703	c.502T>C	synonymous_variant	1.0	isoniazid
inhA	1674708	c.507G>A	synonymous_variant	1.0	ethionamide
inhA	1674708	c.507G>A	synonymous_variant	1.0	isoniazid
inhA	1674718	c.517A>C	synonymous_variant	1.0	ethionamide
inhA	1674718	c.517A>C	synonymous_variant	1.0	isoniazid
inhA	1674723	c.522C>T	synonymous_variant	1.0	ethionamide	Not assoc w R - Interim
inhA	1674723	c.522C>T	synonymous_variant	1.0	isoniazid	Not assoc w R - Interim
inhA	1674738	c.537C>G	synonymous_variant	1.0	ethionamide
inhA	1674738	c.537C>G	synonymous_variant	1.0	isoniazid
inhA	1674741	c.540C>T	synonymous_variant	1.0	ethionamide
inhA	1674741	c.540C>T	synonymous_variant	1.0	isoniazid	Not assoc w R - Interim
inhA	1674746	p.Tyr182Phe	missense_variant	1.0	ethionamide
inhA	1674746	p.Tyr182Phe	missense_variant	1.0	isoniazid
inhA	1674750	c.549T>C	synonymous_variant	1.0	ethionamide
inhA	1674750	c.549T>C	synonymous_variant	1.0	isoniazid
inhA	1674753	c.552G>C	synonymous_variant	1.0	ethionamide
inhA	1674753	c.552G>C	synonymous_variant	1.0	isoniazid
inhA	1674756	c.555T>C	synonymous_variant	1.0	ethionamide	Not assoc w R - Interim
inhA	1674756	c.555T>C	synonymous_variant	1.0	isoniazid	Not assoc w R - Interim
inhA	1674759	c.558G>C	synonymous_variant	1.0	ethionamide
inhA	1674759	c.558G>C	synonymous_variant	1.0	isoniazid
inhA	1674774	c.573A>G	synonymous_variant	1.0	ethionamide
inhA	1674774	c.573A>G	synonymous_variant	1.0	isoniazid
inhA	1674780	c.579T>G	synonymous_variant	1.0	ethionamide
inhA	1674780	c.579T>G	synonymous_variant	1.0	isoniazid
inhA	1674789	c.588G>C	synonymous_variant	1.0	ethionamide
inhA	1674789	c.588G>C	synonymous_variant	1.0	isoniazid
inhA	1674801	c.600T>C	synonymous_variant	1.0	ethionamide
inhA	1674801	c.600T>C	synonymous_variant	1.0	isoniazid
inhA	1674822	c.621C>G	synonymous_variant	1.0	ethionamide
inhA	1674822	c.621C>G	synonymous_variant	1.0	isoniazid
inhA	1674828	c.627G>A	synonymous_variant	1.0	ethionamide
inhA	1674828	c.627G>A	synonymous_variant	1.0	isoniazid
inhA	1674846	p.Ile215Met	missense_variant	0.97	ethionamide
inhA	1674846	p.Ile215Met	missense_variant	0.97	isoniazid
inhA	1674855	c.654C>G	synonymous_variant	0.97	ethionamide
inhA	1674855	c.654C>G	synonymous_variant	0.97	isoniazid	Not assoc w R - Interim
inhA	1674864	c.663C>T	synonymous_variant	0.96	ethionamide	Not assoc w R - Interim
inhA	1674864	c.663C>T	synonymous_variant	0.96	isoniazid	Not assoc w R - Interim
inhA	1674870	c.669T>C	synonymous_variant	0.92	ethionamide
inhA	1674870	c.669T>C	synonymous_variant	0.92	isoniazid
inhA	1674879	c.678T>C	synonymous_variant	0.92	ethionamide
inhA	1674879	c.678T>C	synonymous_variant	0.92	isoniazid
inhA	1674903	c.702T>C	synonymous_variant	0.92	ethionamide
inhA	1674903	c.702T>C	synonymous_variant	0.92	isoniazid
inhA	1674904	p.Ala235Pro	missense_variant	0.92	ethionamide
inhA	1674904	p.Ala235Pro	missense_variant	0.92	isoniazid
inhA	1674909	c.708G>A	synonymous_variant	0.91	ethionamide
inhA	1674909	c.708G>A	synonymous_variant	0.91	isoniazid
inhA	1674942	c.741T>G	synonymous_variant	0.89	ethionamide
inhA	1674942	c.741T>G	synonymous_variant	0.89	isoniazid
rpsA	1833554	p.Thr5Ala	missense_variant	1.0	pyrazinamide	Uncertain significance
rpsA	1833568	c.27G>C	synonymous_variant	0.95	pyrazinamide	Not assoc w R - Interim
rpsA	1833589	c.48A>T	synonymous_variant	0.92	pyrazinamide
rpsA	1833595	c.54T>C	synonymous_variant	0.89	pyrazinamide
rpsA	1833661	c.120A>G	synonymous_variant	0.91	pyrazinamide
rpsA	1833667	c.126C>G	synonymous_variant	0.91	pyrazinamide
rpsA	1833721	c.180A>G	synonymous_variant	0.93	pyrazinamide
rpsA	1833724	c.183C>G	synonymous_variant	0.93	pyrazinamide
rpsA	1833727	c.186G>C	synonymous_variant	0.93	pyrazinamide
rpsA	1833742	c.201A>G	synonymous_variant	0.95	pyrazinamide
rpsA	1833745	c.204G>C	synonymous_variant	0.98	pyrazinamide
rpsA	1833748	c.207C>G	synonymous_variant	0.98	pyrazinamide
rpsA	1833787	c.246C>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833790	c.249T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1833802	c.261A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833811	c.270G>T	synonymous_variant	1.0	pyrazinamide
rpsA	1833838	c.297G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1833841	c.300C>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833847	c.306C>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833856	c.315A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833874	c.333T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1833928	c.387G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1833940	c.399C>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833971	c.430C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1833979	c.438T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834000	c.459G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834021	c.480C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834030	c.489C>G	synonymous_variant	1.0	pyrazinamide
rpsA	1834099	c.558C>G	synonymous_variant	0.97	pyrazinamide
rpsA	1834102	c.561T>C	synonymous_variant	0.91	pyrazinamide
rpsA	1834105	c.564C>G	synonymous_variant	0.91	pyrazinamide
rpsA	1834108	c.567C>G	synonymous_variant	0.97	pyrazinamide
rpsA	1834123	c.582C>G	synonymous_variant	0.94	pyrazinamide
rpsA	1834150	c.609G>C	synonymous_variant	0.9	pyrazinamide
rpsA	1834153	c.612T>C	synonymous_variant	0.89	pyrazinamide
rpsA	1834154	c.613_615delAACinsCG	frameshift_variant&missense_variant	0.89	pyrazinamide	Uncertain significance
rpsA	1834157	c.616T>C	synonymous_variant	0.89	pyrazinamide
rpsA	1834162	c.621A>G	synonymous_variant	0.9	pyrazinamide	Not assoc w R - Interim
rpsA	1834165	c.624A>G	synonymous_variant	0.9	pyrazinamide
rpsA	1834169	p.Thr210Ala	missense_variant	0.91	pyrazinamide	Uncertain significance
rpsA	1834177	c.636A>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
rpsA	1834189	c.648G>C	synonymous_variant	0.93	pyrazinamide
rpsA	1834195	c.654G>C	synonymous_variant	0.93	pyrazinamide
rpsA	1834210	c.669C>T	synonymous_variant	0.94	pyrazinamide
rpsA	1834222	c.681T>C	synonymous_variant	0.92	pyrazinamide
rpsA	1834231	c.690T>C	synonymous_variant	0.96	pyrazinamide
rpsA	1834234	c.693G>C	synonymous_variant	0.95	pyrazinamide
rpsA	1834249	c.708T>C	synonymous_variant	0.94	pyrazinamide
rpsA	1834261	c.720A>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
rpsA	1834262	c.721_723delTCGinsAGC	synonymous_variant	1.0	pyrazinamide
rpsA	1834303	c.762T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834306	c.765T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834609	c.1068T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834633	c.1092A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1834639	c.1098T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834654	p.Glu371Asp	missense_variant	1.0	pyrazinamide
rpsA	1834684	c.1143C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834690	c.1149T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834732	c.1191T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834733	p.Ala398Ser	missense_variant	1.0	pyrazinamide
rpsA	1834738	c.1197A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1834753	c.1212T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834765	p.Glu408Asp	missense_variant	1.0	pyrazinamide
rpsA	1834775	p.Ala412Thr	missense_variant	1.0	pyrazinamide
rpsA	1834780	c.1239A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1834786	c.1245A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1834789	c.1248T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834792	c.1251G>C	synonymous_variant	1.0	pyrazinamide
bacA	2064892	c.-164A>G	upstream_gene_variant	0.8	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064897	c.-169C>G	upstream_gene_variant	0.82	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064903	c.-175G>A	upstream_gene_variant	0.83	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064912	c.-184A>G	upstream_gene_variant	0.86	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064915	c.-187G>C	upstream_gene_variant	0.86	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064933	c.-205A>G	upstream_gene_variant	0.9	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064936	c.-208C>G	upstream_gene_variant	0.9	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064942	c.-214G>A	upstream_gene_variant	0.9	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064948	c.-220G>C	upstream_gene_variant	0.91	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064972	c.-244T>C	upstream_gene_variant	0.96	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064978	c.-250G>C	upstream_gene_variant	0.96	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064979	c.-251C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064984	c.-256A>G	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064993	c.-265T>C	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
kasA	2517950	c.-165C>G	upstream_gene_variant	1.0	isoniazid
kasA	2517989	c.-126T>C	upstream_gene_variant	1.0	isoniazid
kasA	2517993	c.-122G>T	upstream_gene_variant	1.0	isoniazid
kasA	2518768	c.654C>T	synonymous_variant	1.0	isoniazid
kasA	2518777	c.663C>T	synonymous_variant	1.0	isoniazid
kasA	2518783	c.669T>C	synonymous_variant	1.0	isoniazid
kasA	2518789	c.675G>C	synonymous_variant	1.0	isoniazid
kasA	2518792	c.678C>A	synonymous_variant	1.0	isoniazid
kasA	2518795	c.681C>G	synonymous_variant	1.0	isoniazid
kasA	2518825	c.711T>C	synonymous_variant	1.0	isoniazid
kasA	2519196	p.Thr361Ser	missense_variant	0.9	isoniazid
kasA	2519215	c.1101C>T	synonymous_variant	0.9	isoniazid
kasA	2519218	c.1104G>A	synonymous_variant	0.9	isoniazid
kasA	2519221	c.1107G>C	synonymous_variant	0.9	isoniazid
kasA	2519227	c.1113G>C	synonymous_variant	0.9	isoniazid
kasA	2519230	c.1116C>T	synonymous_variant	0.9	isoniazid
kasA	2519236	c.1122G>A	synonymous_variant	0.9	isoniazid
kasA	2519239	c.1125A>C	synonymous_variant	0.9	isoniazid
kasA	2519245	c.1131T>C	synonymous_variant	0.9	isoniazid
kasA	2519260	c.1146T>G	synonymous_variant	0.82	isoniazid
kasA	2519263	c.1149C>T	synonymous_variant	0.8	isoniazid
kasA	2519266	c.1152C>T	synonymous_variant	0.8	isoniazid
kasA	2519269	c.1155C>T	synonymous_variant	0.8	isoniazid
kasA	2519272	c.1158C>G	synonymous_variant	0.8	isoniazid
folC	2746321	c.1278A>G	synonymous_variant	1.0	para-aminosalicylic_acid
folC	2746328	p.Arg424Thr	missense_variant	1.0	para-aminosalicylic_acid
folC	2746335	p.Gly422Arg	missense_variant	1.0	para-aminosalicylic_acid
folC	2746336	c.1263C>G	synonymous_variant	1.0	para-aminosalicylic_acid
folC	2746345	c.1254G>C	synonymous_variant	0.92	para-aminosalicylic_acid
folC	2746351	c.1246_1248delGCCinsTG	frameshift_variant&missense_variant	0.92	para-aminosalicylic_acid
folC	2746354	c.1245G>A	synonymous_variant	1.0	para-aminosalicylic_acid
folC	2746363	c.1234_1236delCTGinsGC	frameshift_variant&missense_variant	1.0	para-aminosalicylic_acid
folC	2746375	c.1224G>C	synonymous_variant	1.0	para-aminosalicylic_acid
folC	2746390	c.1209G>C	synonymous_variant	1.0	para-aminosalicylic_acid
folC	2746393	c.1206C>G	synonymous_variant	1.0	para-aminosalicylic_acid
folC	2746401	p.Ser400Ala	missense_variant	1.0	para-aminosalicylic_acid
folC	2746402	c.1197T>C	synonymous_variant	1.0	para-aminosalicylic_acid
folC	2746414	c.1183_1185delGAGinsCA	frameshift_variant&missense_variant	1.0	para-aminosalicylic_acid
folC	2746420	c.1179A>C	synonymous_variant	1.0	para-aminosalicylic_acid
folC	2746426	c.1173G>C	synonymous_variant	1.0	para-aminosalicylic_acid
folC	2746438	c.1161G>C	synonymous_variant	1.0	para-aminosalicylic_acid
folC	2746451	p.Gly383Ala	missense_variant	1.0	para-aminosalicylic_acid
folC	2746471	c.1128C>A	synonymous_variant	1.0	para-aminosalicylic_acid
folC	2746478	p.Phe374Tyr	missense_variant	1.0	para-aminosalicylic_acid
folC	2746480	c.1119A>C	synonymous_variant	1.0	para-aminosalicylic_acid
folC	2747264	p.Gly112Ala	missense_variant	0.86	para-aminosalicylic_acid
folC	2747266	c.333C>T	synonymous_variant	0.86	para-aminosalicylic_acid
folC	2747275	c.324T>C	synonymous_variant	0.86	para-aminosalicylic_acid
folC	2747289	p.Pro104Ala	missense_variant	0.86	para-aminosalicylic_acid
folC	2747290	c.309A>G	synonymous_variant	0.86	para-aminosalicylic_acid
folC	2747293	c.306G>A	synonymous_variant	0.86	para-aminosalicylic_acid
folC	2747302	c.297A>G	synonymous_variant	0.87	para-aminosalicylic_acid
folC	2747314	c.285A>C	synonymous_variant	0.88	para-aminosalicylic_acid
folC	2747317	c.282C>G	synonymous_variant	0.88	para-aminosalicylic_acid
folC	2747343	p.Val86Ile	missense_variant	0.89	para-aminosalicylic_acid
folC	2747355	p.Val82Ile	missense_variant	0.89	para-aminosalicylic_acid
folC	2747359	c.240C>G	synonymous_variant	0.88	para-aminosalicylic_acid
folC	2747362	c.237G>C	synonymous_variant	0.88	para-aminosalicylic_acid
Rv2477c	2783194	c.849A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783221	c.822G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783224	c.819C>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783230	c.813T>G	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2783235	c.808T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783254	c.789A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783263	c.780G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783275	c.768C>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783278	c.765A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783293	c.750G>A	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783299	c.744A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783302	c.741A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783311	c.732T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783314	c.729C>G	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					levofloxacin
					kanamycin
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2783317	c.726G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783332	c.711T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783335	c.708C>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783350	c.693T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783353	c.690T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783359	c.684G>A	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783374	c.669G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783761	c.282G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783766	p.Met93Leu	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783776	c.267G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783779	c.264T>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783797	p.Asp82Glu	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783815	c.228A>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783821	p.Gln74Leu	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783833	c.210G>C	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783839	c.204C>G	synonymous_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783843	p.Gly67Asp	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783846	p.Thr66Asn	missense_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783860	c.183T>C	synonymous_variant	0.94	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783863	c.180C>T	synonymous_variant	0.94	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783883	c.160T>C	synonymous_variant	0.94	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783884	c.159T>C	synonymous_variant	0.93	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783887	c.156C>G	synonymous_variant	0.94	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783914	c.129T>C	synonymous_variant	0.94	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783920	c.123G>C	synonymous_variant	0.94	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783929	c.114C>G	synonymous_variant	0.94	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783932	c.111C>T	synonymous_variant	0.94	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783938	c.105T>C	synonymous_variant	0.94	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783953	c.90G>A	synonymous_variant	0.93	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783962	c.81T>C	synonymous_variant	0.94	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783971	c.72G>C	synonymous_variant	0.93	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783980	c.63C>G	synonymous_variant	0.93	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783992	c.51T>C	synonymous_variant	0.93	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2680	2996335	p.Glu77Asp	missense_variant	1.0	capreomycin
Rv2680	2996360	p.Met86Leu	missense_variant	1.0	capreomycin
Rv2681	2996368	c.-371T>C	upstream_gene_variant	1.0	capreomycin
mtrB	3626704	c.-91C>T	upstream_gene_variant	0.91	bedaquiline
mtrB	3626704	c.-91C>T	upstream_gene_variant	0.91	rifampicin
mtrB	3626711	c.-98T>C	upstream_gene_variant	0.92	bedaquiline
mtrB	3626711	c.-98T>C	upstream_gene_variant	0.92	rifampicin
mtrA	3626723	c.627C>T	synonymous_variant	0.93	bedaquiline
mtrA	3626723	c.627C>T	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
mtrB	3626726	c.-113T>C	upstream_gene_variant	0.93	bedaquiline
mtrB	3626726	c.-113T>C	upstream_gene_variant	0.93	rifampicin
mtrB	3626729	c.-116G>A	upstream_gene_variant	0.93	bedaquiline
mtrB	3626729	c.-116G>A	upstream_gene_variant	0.93	rifampicin
mtrB	3626732	c.-119A>G	upstream_gene_variant	0.93	bedaquiline
mtrB	3626732	c.-119A>G	upstream_gene_variant	0.93	rifampicin
mtrA	3626759	c.591T>C	synonymous_variant	1.0	bedaquiline
mtrA	3626759	c.591T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrA	3626774	c.574_576delAGGinsCC	frameshift_variant&missense_variant	1.0	bedaquiline
mtrA	3626774	c.574_576delAGGinsCC	frameshift_variant&missense_variant	1.0	rifampicin
mtrB	3626783	c.-170C>G	upstream_gene_variant	1.0	bedaquiline
mtrB	3626783	c.-170C>G	upstream_gene_variant	1.0	rifampicin
mtrA	3626786	c.564A>G	synonymous_variant	1.0	bedaquiline
mtrA	3626786	c.564A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrA	3626792	c.558G>T	synonymous_variant	1.0	bedaquiline
mtrA	3626792	c.558G>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3626795	c.-182C>T	upstream_gene_variant	1.0	bedaquiline
mtrB	3626795	c.-182C>T	upstream_gene_variant	1.0	rifampicin
mtrB	3626798	c.-185T>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3626798	c.-185T>C	upstream_gene_variant	1.0	rifampicin
mtrA	3626804	c.546A>G	synonymous_variant	1.0	bedaquiline
mtrA	3626804	c.546A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3626840	c.-227C>G	upstream_gene_variant	0.9	bedaquiline
mtrB	3626840	c.-227C>G	upstream_gene_variant	0.9	rifampicin
mtrB	3626957	c.-344G>C	upstream_gene_variant	0.88	bedaquiline
mtrB	3626957	c.-344G>C	upstream_gene_variant	0.88	rifampicin
mtrB	3626972	c.-359A>G	upstream_gene_variant	0.89	bedaquiline
mtrB	3626972	c.-359A>G	upstream_gene_variant	0.89	rifampicin
mtrB	3626987	c.-374C>G	upstream_gene_variant	0.95	bedaquiline
mtrB	3626987	c.-374C>G	upstream_gene_variant	0.95	rifampicin
mtrB	3627008	c.-395G>C	upstream_gene_variant	0.96	bedaquiline
mtrB	3627008	c.-395G>C	upstream_gene_variant	0.96	rifampicin
mtrB	3627011	c.-398T>G	upstream_gene_variant	0.96	bedaquiline
mtrB	3627011	c.-398T>G	upstream_gene_variant	0.96	rifampicin
mtrB	3627065	c.-452G>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3627065	c.-452G>C	upstream_gene_variant	1.0	rifampicin
mtrA	3627068	c.282T>C	synonymous_variant	1.0	bedaquiline
mtrA	3627068	c.282T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrA	3627071	c.279G>T	synonymous_variant	1.0	bedaquiline
mtrA	3627071	c.279G>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3627074	c.-461G>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3627074	c.-461G>C	upstream_gene_variant	1.0	rifampicin
mtrA	3627080	c.270T>C	synonymous_variant	1.0	bedaquiline
mtrA	3627080	c.270T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3627083	c.-470G>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3627083	c.-470G>C	upstream_gene_variant	1.0	rifampicin
mtrA	3627098	c.252A>C	synonymous_variant	1.0	bedaquiline
mtrA	3627098	c.252A>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3627104	c.-491C>G	upstream_gene_variant	1.0	bedaquiline
mtrB	3627104	c.-491C>G	upstream_gene_variant	1.0	rifampicin
mtrB	3627209	c.-596G>A	upstream_gene_variant	1.0	bedaquiline
mtrB	3627209	c.-596G>A	upstream_gene_variant	1.0	rifampicin
mtrA	3627221	c.129C>T	synonymous_variant	1.0	bedaquiline
mtrA	3627221	c.129C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrA	3627227	c.123T>C	synonymous_variant	1.0	bedaquiline
mtrA	3627227	c.123T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3627233	c.-620T>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3627233	c.-620T>C	upstream_gene_variant	1.0	rifampicin
mtrB	3627236	c.-623T>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3627236	c.-623T>C	upstream_gene_variant	1.0	rifampicin
mtrA	3627242	c.108C>T	synonymous_variant	1.0	bedaquiline
mtrA	3627242	c.108C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrB	3627254	c.-641C>T	upstream_gene_variant	1.0	bedaquiline
mtrB	3627254	c.-641C>T	upstream_gene_variant	1.0	rifampicin
mtrB	3627263	c.-650C>T	upstream_gene_variant	1.0	bedaquiline
mtrB	3627263	c.-650C>T	upstream_gene_variant	1.0	rifampicin
mtrB	3627266	c.-653A>G	upstream_gene_variant	1.0	bedaquiline
mtrB	3627266	c.-653A>G	upstream_gene_variant	1.0	rifampicin
mtrB	3627272	c.-659G>T	upstream_gene_variant	0.92	bedaquiline
mtrB	3627272	c.-659G>T	upstream_gene_variant	0.92	rifampicin
mtrB	3627275	c.-662G>T	upstream_gene_variant	1.0	bedaquiline
mtrB	3627275	c.-662G>T	upstream_gene_variant	1.0	rifampicin
mtrB	3627296	c.-683T>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3627296	c.-683T>C	upstream_gene_variant	1.0	rifampicin
mtrA	3627299	c.49_51delTTGinsCA	frameshift_variant&missense_variant	1.0	bedaquiline
mtrA	3627299	c.49_51delTTGinsCA	frameshift_variant&missense_variant	1.0	rifampicin
fbiB	3641864	c.330A>C	synonymous_variant	0.75	clofazimine
					pretomanid
					delamanid
fbiB	3641876	c.342C>G	synonymous_variant	0.75	clofazimine
					pretomanid
					delamanid
fbiB	3641879	c.345G>C	synonymous_variant	0.75	clofazimine
					pretomanid
					delamanid
fbiB	3641880	p.Ser116Asp	missense_variant	0.75	clofazimine
					pretomanid
					delamanid
fbiB	3641888	c.354A>G	synonymous_variant	0.75	clofazimine
					pretomanid
					delamanid
fbiB	3641891	c.357G>C	synonymous_variant	0.75	clofazimine
					pretomanid
					delamanid
fbiB	3641900	c.366G>C	synonymous_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiB	3641906	c.372T>C	synonymous_variant	0.9	clofazimine
					pretomanid
					delamanid
fbiB	3641909	c.375T>G	synonymous_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiB	3641914	p.Ala127Gly	missense_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiB	3641918	c.384T>C	synonymous_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiB	3641924	c.390A>C	synonymous_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiB	3641927	c.393C>G	synonymous_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiB	3641928	c.394T>C	synonymous_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiB	3641938	p.Gly135Ala	missense_variant	0.82	clofazimine
					pretomanid
					delamanid
fbiB	3641961	p.Thr143Glu	missense_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiB	3642656	c.1122G>C	synonymous_variant	0.88	clofazimine
					pretomanid
					delamanid
fbiB	3642659	c.1125C>G	synonymous_variant	0.89	clofazimine
					pretomanid
					delamanid
fbiB	3642668	c.1134A>G	synonymous_variant	0.89	clofazimine
					pretomanid
					delamanid
fbiB	3642677	c.1143A>G	synonymous_variant	0.9	clofazimine
					pretomanid
					delamanid
fbiB	3642680	c.1146A>G	synonymous_variant	0.95	clofazimine
					pretomanid
					delamanid
fbiB	3642684	c.1150T>C	synonymous_variant	0.95	clofazimine
					pretomanid
					delamanid
fbiB	3642701	c.1167C>G	synonymous_variant	0.95	clofazimine
					pretomanid
					delamanid
fbiB	3642719	c.1185T>C	synonymous_variant	0.89	clofazimine
					pretomanid
					delamanid
fbiB	3642731	c.1197C>G	synonymous_variant	0.88	clofazimine
					pretomanid
					delamanid
fbiB	3642743	c.1209T>C	synonymous_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiB	3642749	c.1215T>C	synonymous_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiB	3642758	c.1224C>G	synonymous_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiB	3642763	p.Asp410Ala	missense_variant	0.94	clofazimine
					pretomanid
					delamanid
fbiB	3642770	c.1236G>C	synonymous_variant	0.93	clofazimine
					pretomanid
					delamanid
fbiB	3642779	c.1245A>C	synonymous_variant	0.92	clofazimine
					pretomanid
					delamanid
fbiB	3642781	p.Val416Ala	missense_variant	0.92	clofazimine
					pretomanid
					delamanid
rpoA	3877503	c.1005G>C	synonymous_variant	1.0	rifampicin
rpoA	3877507	p.Gly334Ala	missense_variant	1.0	rifampicin
rpoA	3877515	c.993G>C	synonymous_variant	1.0	rifampicin
rpoA	3877553	p.Glu319Gln	missense_variant	1.0	rifampicin
rpoA	3877571	p.Pro313Ala	missense_variant	1.0	rifampicin
rpoA	3877587	c.921A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877613	p.Ile299Val	missense_variant	1.0	rifampicin
rpoA	3877656	c.852T>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877668	c.840A>G	synonymous_variant	1.0	rifampicin
rpoA	3877679	p.Ala277Ser	missense_variant	1.0	rifampicin
rpoA	3877686	c.822A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877692	c.816G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877704	c.804G>C	synonymous_variant	1.0	rifampicin
rpoA	3877743	c.765T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877764	c.744C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877770	c.738A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877776	c.732T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877782	c.726T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877791	c.717C>G	synonymous_variant	1.0	rifampicin
rpoA	3877818	c.690A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877839	c.669G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877848	c.660C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877857	c.651G>A	synonymous_variant	1.0	rifampicin
rpoA	3877866	c.642G>C	synonymous_variant	1.0	rifampicin
rpoA	3877875	c.633T>G	synonymous_variant	1.0	rifampicin
rpoA	3877878	c.630G>C	synonymous_variant	1.0	rifampicin
rpoA	3877890	c.618C>T	synonymous_variant	1.0	rifampicin
rpoA	3877896	c.612G>C	synonymous_variant	1.0	rifampicin
rpoA	3877900	p.Ser203Asn	missense_variant	1.0	rifampicin
rpoA	3877905	c.603A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877909	p.Asn200Ser	missense_variant	1.0	rifampicin
rpoA	3877920	c.588G>C	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoA	3877923	c.585C>T	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoA	3877926	c.582G>C	synonymous_variant	0.97	rifampicin
rpoA	3877962	c.546G>T	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoA	3877986	c.522G>C	synonymous_variant	0.97	rifampicin
rpoA	3877989	c.519A>G	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoA	3878001	c.507A>G	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoA	3878022	c.486T>C	synonymous_variant	0.93	rifampicin
rpoA	3878028	c.480G>C	synonymous_variant	0.93	rifampicin
rpoA	3878031	c.477T>C	synonymous_variant	0.93	rifampicin
rpoA	3878040	c.468T>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoA	3878043	c.465G>A	synonymous_variant	0.92	rifampicin
rpoA	3878055	c.453A>G	synonymous_variant	0.89	rifampicin
rpoA	3878058	c.450G>T	synonymous_variant	0.89	rifampicin
rpoA	3878061	c.447G>C	synonymous_variant	0.89	rifampicin
rpoA	3878067	c.441C>G	synonymous_variant	0.89	rifampicin
rpoA	3878070	c.438T>C	synonymous_variant	0.94	rifampicin
rpoA	3878076	c.432C>T	synonymous_variant	0.95	rifampicin
rpoA	3878082	c.426T>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoA	3878094	c.414C>G	synonymous_variant	0.94	rifampicin
rpoA	3878103	c.405A>G	synonymous_variant	0.95	rifampicin
rpoA	3878106	c.402G>C	synonymous_variant	0.95	rifampicin
rpoA	3878118	c.390T>C	synonymous_variant	0.94	rifampicin
rpoA	3878130	c.378C>G	synonymous_variant	0.94	rifampicin
rpoA	3878141	p.Met123Leu	missense_variant	0.95	rifampicin	Uncertain significance
rpoA	3878143	p.Gly122Asp	missense_variant	0.95	rifampicin	Uncertain significance
rpoA	3878157	c.351C>G	synonymous_variant	0.96	rifampicin
rpoA	3878163	c.345C>T	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoA	3878169	c.339G>C	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoA	3878172	c.336G>C	synonymous_variant	1.0	rifampicin
rpoA	3878181	c.327C>T	synonymous_variant	1.0	rifampicin
rpoA	3878187	c.321C>G	synonymous_variant	1.0	rifampicin
rpoA	3878193	c.315T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878199	c.309T>C	synonymous_variant	1.0	rifampicin
rpoA	3878217	c.291A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878226	c.282C>G	synonymous_variant	1.0	rifampicin
rpoA	3878232	c.276G>C	synonymous_variant	1.0	rifampicin
rpoA	3878247	c.261G>C	synonymous_variant	1.0	rifampicin
rpoA	3878271	c.237T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878284	p.Glu75Ala	missense_variant	1.0	rifampicin
rpoA	3878292	c.216T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878298	c.210A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878304	c.204G>C	synonymous_variant	1.0	rifampicin
rpoA	3878313	c.195G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878322	c.186A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878331	c.177A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878334	c.174T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878337	c.171T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878340	c.168C>T	synonymous_variant	1.0	rifampicin
rpoA	3878346	c.162T>C	synonymous_variant	1.0	rifampicin
rpoA	3878364	c.144A>T	synonymous_variant	1.0	rifampicin
rpoA	3878367	c.141C>G	synonymous_variant	1.0	rifampicin
rpoA	3878376	c.132G>C	synonymous_variant	1.0	rifampicin
rpoA	3878385	c.123C>G	synonymous_variant	1.0	rifampicin
rpoA	3878388	c.120C>G	synonymous_variant	1.0	rifampicin
rpoA	3878391	c.117T>C	synonymous_variant	1.0	rifampicin
rpoA	3878415	c.93C>T	synonymous_variant	0.98	rifampicin
rpoA	3878424	c.84G>C	synonymous_variant	0.98	rifampicin
rpoA	3878436	c.72A>G	synonymous_variant	0.98	rifampicin
rpoA	3878442	c.66G>C	synonymous_variant	0.97	rifampicin
rpoA	3878454	c.54A>C	synonymous_variant	0.97	rifampicin
rpoA	3878472	p.Asp12Glu	missense_variant	0.95	rifampicin
rpoA	3878478	c.30C>G	synonymous_variant	0.95	rifampicin
rpoA	3878484	c.24C>A	synonymous_variant	0.95	rifampicin
rpoA	3878490	c.18C>A	synonymous_variant	0.95	rifampicin
rpoA	3878496	c.12A>T	synonymous_variant	0.94	rifampicin
rpoA	3878713	c.-206G>A	upstream_gene_variant	1.0	rifampicin	Uncertain significance
rpoA	3878716	c.-209C>G	upstream_gene_variant	1.0	rifampicin
rpoA	3878725	c.-218A>G	upstream_gene_variant	1.0	rifampicin
rpoA	3878736	c.-229A>G	upstream_gene_variant	1.0	rifampicin
rpoA	3878737	c.-230G>C	upstream_gene_variant	1.0	rifampicin
rpoA	3878742	c.-235G>A	upstream_gene_variant	1.0	rifampicin
rpoA	3878746	c.-239A>G	upstream_gene_variant	1.0	rifampicin	Uncertain significance
rpoA	3878749	c.-242G>T	upstream_gene_variant	1.0	rifampicin
rpoA	3878761	c.-254G>C	upstream_gene_variant	1.0	rifampicin
rpoA	3878764	c.-257A>G	upstream_gene_variant	1.0	rifampicin
rpoA	3878785	c.-278T>G	upstream_gene_variant	1.0	rifampicin
rpoA	3878788	c.-281G>C	upstream_gene_variant	1.0	rifampicin	Uncertain significance
rpoA	3878806	c.-299C>G	upstream_gene_variant	1.0	rifampicin
rpoA	3878809	c.-302T>C	upstream_gene_variant	1.0	rifampicin
rpoA	3878824	c.-317G>C	upstream_gene_variant	1.0	rifampicin
rpoA	3878833	c.-326C>G	upstream_gene_variant	0.97	rifampicin
rpoA	3878836	c.-331_-329delAAGinsTCC	upstream_gene_variant	0.96	rifampicin
rpoA	3878853	c.-346G>A	upstream_gene_variant	0.97	rifampicin
rpoA	3878860	c.-353C>T	upstream_gene_variant	0.93	rifampicin
rpoA	3878878	c.-371T>C	upstream_gene_variant	0.9	rifampicin	Uncertain significance
rpoA	3878909	c.-402A>G	upstream_gene_variant	0.88	rifampicin
rpoA	3878914	c.-407T>C	upstream_gene_variant	0.88	rifampicin	Uncertain significance
rpoA	3878917	c.-410G>A	upstream_gene_variant	0.88	rifampicin	Uncertain significance
rpoA	3878938	c.-431T>A	upstream_gene_variant	0.87	rifampicin
rpoA	3878947	c.-440G>C	upstream_gene_variant	0.86	rifampicin	Uncertain significance
rpoA	3878962	c.-455G>A	upstream_gene_variant	0.86	rifampicin	Uncertain significance
rpoA	3878968	c.-461T>C	upstream_gene_variant	0.85	rifampicin	Uncertain significance
rpoA	3878976	c.-469A>G	upstream_gene_variant	0.86	rifampicin	Uncertain significance
rpoA	3878986	c.-479G>C	upstream_gene_variant	0.89	rifampicin
rpoA	3878998	c.-491C>G	upstream_gene_variant	0.89	rifampicin	Uncertain significance
rpoA	3879005	c.-499_-498delAAinsCG	upstream_gene_variant	0.89	rifampicin
rpoA	3879013	c.-506A>G	upstream_gene_variant	0.93	rifampicin
rpoA	3879079	c.-572A>G	upstream_gene_variant	0.96	rifampicin
rpoA	3879088	c.-581A>C	upstream_gene_variant	0.96	rifampicin
rpoA	3879094	c.-587T>C	upstream_gene_variant	0.98	rifampicin
rpoA	3879121	c.-614T>G	upstream_gene_variant	0.98	rifampicin
rpoA	3879127	c.-620T>C	upstream_gene_variant	0.97	rifampicin
rpoA	3879154	c.-647T>C	upstream_gene_variant	0.93	rifampicin
rpoA	3879160	c.-653A>G	upstream_gene_variant	0.93	rifampicin
rpoA	3879178	c.-671T>C	upstream_gene_variant	0.96	rifampicin
rpoA	3879190	c.-683C>G	upstream_gene_variant	0.95	rifampicin
rpoA	3879222	c.-715T>C	upstream_gene_variant	0.86	rifampicin
rpoA	3879226	c.-719G>C	upstream_gene_variant	0.86	rifampicin
rpoA	3879229	c.-722A>G	upstream_gene_variant	0.86	rifampicin
rpoA	3879232	c.-725A>G	upstream_gene_variant	0.86	rifampicin
clpC1	4038239	c.2466T>C	synonymous_variant	0.93	pyrazinamide
clpC1	4038255	p.Val817Lys	missense_variant	0.94	pyrazinamide
clpC1	4038271	p.Pro812Ala	missense_variant	1.0	pyrazinamide
clpC1	4038272	c.2431_2433delGGTinsAC	frameshift_variant&missense_variant	1.0	pyrazinamide
clpC1	4038275	c.2430A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4038278	c.2427T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038293	c.2412G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038302	c.2403C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4038308	c.2397G>T	synonymous_variant	1.0	pyrazinamide
clpC1	4038314	c.2391T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038317	c.2388G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038320	c.2385G>T	synonymous_variant	1.0	pyrazinamide
clpC1	4038356	c.2349T>C	synonymous_variant	0.96	pyrazinamide
clpC1	4038359	c.2346A>G	synonymous_variant	0.96	pyrazinamide
clpC1	4038368	c.2337T>C	synonymous_variant	0.96	pyrazinamide
clpC1	4038386	c.2317_2319delTTGinsCC	frameshift_variant&missense_variant	0.95	pyrazinamide
clpC1	4038392	c.2313C>T	synonymous_variant	0.95	pyrazinamide
clpC1	4038398	c.2307G>T	synonymous_variant	0.95	pyrazinamide
clpC1	4038403	c.2302T>C	synonymous_variant	0.96	pyrazinamide	Not assoc w R - Interim
clpC1	4038407	c.2298G>C	synonymous_variant	0.96	pyrazinamide
clpC1	4038419	c.2286T>C	synonymous_variant	0.97	pyrazinamide
clpC1	4038433	c.2272C>T	synonymous_variant	0.93	pyrazinamide
clpC1	4038434	c.2271G>A	synonymous_variant	0.97	pyrazinamide
clpC1	4038444	p.Ala754Lys	missense_variant	0.96	pyrazinamide
clpC1	4038446	c.2259T>C	synonymous_variant	0.96	pyrazinamide
clpC1	4038456	p.Val750Glu	missense_variant	0.97	pyrazinamide
clpC1	4038460	p.Leu749Met	missense_variant	0.97	pyrazinamide
clpC1	4038486	p.Gly740Asn	missense_variant	0.97	pyrazinamide
clpC1	4038489	p.Ala739Gly	missense_variant	0.97	pyrazinamide
clpC1	4038494	c.2211G>C	synonymous_variant	0.97	pyrazinamide
clpC1	4038497	p.Ser736Gln	missense_variant	0.97	pyrazinamide
clpC1	4038509	c.2196C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4038530	p.Glu725Asp	missense_variant	1.0	pyrazinamide
clpC1	4038596	c.2109A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4038623	c.2082A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4038640	p.Asp689Asn	missense_variant	1.0	pyrazinamide
clpC1	4038653	c.2052C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4038658	p.Lys683Gln	missense_variant	1.0	pyrazinamide
clpC1	4038661	p.Ser682Thr	missense_variant	1.0	pyrazinamide
clpC1	4038662	c.2043T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038671	c.2034T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038683	c.2022T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4038695	c.2010C>G	synonymous_variant	0.97	pyrazinamide
clpC1	4038701	c.2004G>C	synonymous_variant	0.97	pyrazinamide
clpC1	4038704	c.2001T>C	synonymous_variant	0.97	pyrazinamide
clpC1	4038707	c.1998C>G	synonymous_variant	0.97	pyrazinamide
clpC1	4038710	c.1995G>C	synonymous_variant	0.97	pyrazinamide
clpC1	4038713	c.1992T>C	synonymous_variant	0.97	pyrazinamide
clpC1	4038749	c.1956C>A	synonymous_variant	0.94	pyrazinamide
clpC1	4038755	c.1950G>T	synonymous_variant	0.94	pyrazinamide
clpC1	4038770	c.1935C>T	synonymous_variant	0.93	pyrazinamide
clpC1	4038773	c.1932T>C	synonymous_variant	0.93	pyrazinamide
clpC1	4038782	c.1923G>C	synonymous_variant	0.93	pyrazinamide
clpC1	4038812	c.1893T>C	synonymous_variant	0.93	pyrazinamide
clpC1	4038845	c.1860G>C	synonymous_variant	0.94	pyrazinamide
clpC1	4038860	c.1845G>C	synonymous_variant	0.97	pyrazinamide	Not assoc w R - Interim
clpC1	4038878	c.1827A>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4038893	c.1812C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4038908	c.1797C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4038914	c.1791G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038923	c.1780_1782delCTAinsTG	frameshift_variant&synonymous_variant	1.0	pyrazinamide
clpC1	4038953	c.1752A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4038956	c.1749T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038965	c.1740T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038971	c.1734T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4038974	c.1731T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4038989	c.1716T>C	synonymous_variant	0.95	pyrazinamide
clpC1	4038997	c.1708T>C	synonymous_variant	0.95	pyrazinamide	Not assoc w R - Interim
clpC1	4039004	c.1701C>G	synonymous_variant	0.96	pyrazinamide
clpC1	4039022	c.1683A>G	synonymous_variant	0.96	pyrazinamide
clpC1	4039064	c.1641C>T	synonymous_variant	0.96	pyrazinamide
clpC1	4039097	c.1608G>C	synonymous_variant	0.94	pyrazinamide
clpC1	4039103	c.1602T>C	synonymous_variant	0.93	pyrazinamide
clpC1	4039106	c.1599G>C	synonymous_variant	0.94	pyrazinamide
clpC1	4039112	c.1593C>G	synonymous_variant	0.94	pyrazinamide
clpC1	4039121	c.1584T>C	synonymous_variant	0.94	pyrazinamide
clpC1	4039142	c.1563A>G	synonymous_variant	0.95	pyrazinamide
clpC1	4039145	c.1560G>C	synonymous_variant	0.95	pyrazinamide
clpC1	4039169	p.Glu512Asp	missense_variant	0.95	pyrazinamide
clpC1	4039172	c.1533A>G	synonymous_variant	0.95	pyrazinamide
clpC1	4039178	c.1527G>C	synonymous_variant	0.95	pyrazinamide
clpC1	4039183	c.1522T>C	synonymous_variant	0.94	pyrazinamide
clpC1	4039186	c.1519C>T	synonymous_variant	0.94	pyrazinamide
clpC1	4039190	c.1515C>G	synonymous_variant	0.94	pyrazinamide
clpC1	4039226	c.1479T>C	synonymous_variant	0.93	pyrazinamide	Not assoc w R - Interim
clpC1	4039229	c.1476C>G	synonymous_variant	0.94	pyrazinamide
clpC1	4039274	c.1431G>C	synonymous_variant	0.97	pyrazinamide	Not assoc w R - Interim
clpC1	4039286	c.1419T>C	synonymous_variant	0.97	pyrazinamide
clpC1	4039295	c.1410A>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039298	c.1407T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039319	c.1386T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4039322	c.1383T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039328	c.1377A>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039331	c.1374C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039337	p.Thr456Gln	missense_variant	1.0	pyrazinamide
clpC1	4039349	c.1356C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4039352	c.1353C>G	synonymous_variant	0.97	pyrazinamide
clpC1	4039364	c.1341C>G	synonymous_variant	0.97	pyrazinamide
clpC1	4039391	c.1314T>G	synonymous_variant	0.94	pyrazinamide
clpC1	4039409	c.1296T>C	synonymous_variant	0.93	pyrazinamide
clpC1	4039412	c.1293T>G	synonymous_variant	0.93	pyrazinamide
clpC1	4039415	p.Glu430Asp	missense_variant	0.93	pyrazinamide	Uncertain significance
clpC1	4039430	c.1275T>C	synonymous_variant	0.92	pyrazinamide
clpC1	4039481	c.1224T>C	synonymous_variant	0.83	pyrazinamide
clpC1	4039484	c.1221T>C	synonymous_variant	0.85	pyrazinamide
clpC1	4039517	c.1188C>G	synonymous_variant	0.95	pyrazinamide
clpC1	4039556	c.1149G>C	synonymous_variant	0.95	pyrazinamide
clpC1	4039559	c.1146C>G	synonymous_variant	0.95	pyrazinamide
clpC1	4039562	c.1143C>G	synonymous_variant	0.95	pyrazinamide
clpC1	4039565	c.1140G>C	synonymous_variant	0.95	pyrazinamide
clpC1	4039570	p.Met379Leu	missense_variant	0.95	pyrazinamide	Uncertain significance
clpC1	4039576	p.Ala377Pro	missense_variant	0.95	pyrazinamide
clpC1	4039577	c.1128T>C	synonymous_variant	0.95	pyrazinamide	Not assoc w R - Interim
clpC1	4039589	c.1116G>C	synonymous_variant	0.96	pyrazinamide
clpC1	4039610	c.1095G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039616	c.1089G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039928	c.775_777delAGCinsTCG	synonymous_variant	1.0	pyrazinamide
clpC1	4039931	c.774T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039937	c.768G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039946	c.759A>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039952	c.753T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039982	c.723G>A	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4039988	c.717C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039991	c.714G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040021	c.684A>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040024	c.681A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040033	c.672G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040036	c.669C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040090	c.613_615delTCTinsAGC	synonymous_variant	1.0	pyrazinamide
clpC1	4040093	c.612C>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040105	c.600C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040147	c.558A>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040162	c.543G>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040165	c.540G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040171	c.534C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040201	c.504C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040207	c.498T>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040210	c.495G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040213	c.490_492delTCTinsAGC	synonymous_variant	1.0	pyrazinamide
clpC1	4040225	c.480A>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040228	c.477G>T	synonymous_variant	1.0	pyrazinamide
clpC1	4040237	c.468C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4040246	c.459C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040249	c.456A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040267	c.438A>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040273	c.432T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040276	c.427_429delTCCinsAGT	synonymous_variant	1.0	pyrazinamide
clpC1	4040279	c.426C>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040291	c.414G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040318	c.387C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040330	c.375C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040342	c.363C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040354	c.351A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040363	c.342A>T	synonymous_variant	1.0	pyrazinamide
clpC1	4040369	c.336C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040380	c.325T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040381	c.324T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040387	c.318A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040393	c.312G>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040411	c.294T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040423	c.282A>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040426	c.279T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040431	c.274T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040444	c.261C>T	synonymous_variant	1.0	pyrazinamide
clpC1	4040450	c.255A>G	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040459	c.246C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4040465	c.240T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040471	c.234T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
clpC1	4040477	c.228G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4040480	c.225T>G	synonymous_variant	0.96	pyrazinamide
clpC1	4040522	c.183T>C	synonymous_variant	0.91	pyrazinamide	Not assoc w R - Interim
clpC1	4040528	c.177G>T	synonymous_variant	0.95	pyrazinamide
clpC1	4040531	c.174T>C	synonymous_variant	0.95	pyrazinamide
clpC1	4040534	c.171A>G	synonymous_variant	0.9	pyrazinamide	Not assoc w R - Interim
clpC1	4040537	c.168G>C	synonymous_variant	0.9	pyrazinamide
clpC1	4040546	c.159G>C	synonymous_variant	0.89	pyrazinamide
clpC1	4040551	c.154T>C	synonymous_variant	0.89	pyrazinamide	Not assoc w R - Interim
clpC1	4040561	c.144A>G	synonymous_variant	0.85	pyrazinamide
clpC1	4040567	c.138C>G	synonymous_variant	0.82	pyrazinamide
panD	4044737	c.-456T>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044746	c.-467_-465delGTGinsAC	upstream_gene_variant	1.0	pyrazinamide
panD	4044752	c.-471T>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044779	c.-500_-498delCTAinsTGC	upstream_gene_variant	1.0	pyrazinamide
panD	4044788	c.-507G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044791	c.-510G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044800	c.-519C>G	upstream_gene_variant	1.0	pyrazinamide
panD	4044812	c.-531A>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044818	c.-538_-537delCGinsAC	upstream_gene_variant	1.0	pyrazinamide
panD	4044823	c.-542G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044833	c.-552A>G	upstream_gene_variant	1.0	pyrazinamide
panD	4044844	c.-563T>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044848	c.-567T>A	upstream_gene_variant	1.0	pyrazinamide
panD	4044854	c.-573A>G	upstream_gene_variant	1.0	pyrazinamide
panD	4044860	c.-579C>G	upstream_gene_variant	1.0	pyrazinamide
panD	4044872	c.-591C>G	upstream_gene_variant	1.0	pyrazinamide
panD	4044890	c.-609G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044895	c.-614A>G	upstream_gene_variant	1.0	pyrazinamide
panD	4044896	c.-615T>G	upstream_gene_variant	1.0	pyrazinamide
panD	4044902	c.-623_-621delACGinsGC	upstream_gene_variant	1.0	pyrazinamide
panD	4044908	c.-628_-627delCTinsTC	upstream_gene_variant	1.0	pyrazinamide
panD	4044917	c.-636G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044926	c.-645C>A	upstream_gene_variant	1.0	pyrazinamide
panD	4044929	c.-648G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044935	c.-655_-654delAAinsTG	upstream_gene_variant	1.0	pyrazinamide
panD	4044941	c.-660G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4044954	c.-674_-673delCCinsAT	upstream_gene_variant	1.0	pyrazinamide
panD	4044980	c.-699A>G	upstream_gene_variant	1.0	pyrazinamide
panD	4044983	c.-702G>T	upstream_gene_variant	1.0	pyrazinamide
panD	4044989	c.-708T>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045000	c.-719A>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045001	c.-720G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045019	c.-738G>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045022	c.-741C>G	upstream_gene_variant	1.0	pyrazinamide
panD	4045028	c.-747C>G	upstream_gene_variant	1.0	pyrazinamide
panD	4045034	c.-753A>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045055	c.-774T>G	upstream_gene_variant	1.0	pyrazinamide
panD	4045067	c.-786C>G	upstream_gene_variant	1.0	pyrazinamide
panD	4045070	c.-789C>T	upstream_gene_variant	1.0	pyrazinamide
panD	4045076	c.-795A>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045088	c.-807T>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045094	c.-813T>C	upstream_gene_variant	1.0	pyrazinamide
panD	4045097	c.-816T>C	upstream_gene_variant	1.0	pyrazinamide
embC	4240726	c.864G>C	synonymous_variant	0.94	ethambutol	Not assoc w R - Interim
embC	4240780	c.918T>C	synonymous_variant	0.95	ethambutol
embC	4240783	c.921G>C	synonymous_variant	0.95	ethambutol
embC	4240789	c.927T>C	synonymous_variant	0.95	ethambutol
embC	4240819	c.957A>G	synonymous_variant	0.96	ethambutol
embC	4240828	c.966G>A	synonymous_variant	0.95	ethambutol
embC	4240831	c.969T>G	synonymous_variant	0.95	ethambutol
embC	4240867	c.1005T>C	synonymous_variant	0.92	ethambutol
embC	4240870	c.1008T>C	synonymous_variant	0.92	ethambutol
embC	4240873	c.1011C>G	synonymous_variant	0.91	ethambutol
embC	4240879	c.1017G>C	synonymous_variant	0.91	ethambutol
embC	4240880	p.Ala340Thr	missense_variant	0.91	ethambutol	Uncertain significance
embC	4240885	c.1023T>C	synonymous_variant	0.91	ethambutol
embB	4245659	c.-855C>G	upstream_gene_variant	0.8	ethambutol
embA	4245674	c.2442A>C	synonymous_variant	0.82	ethambutol	Not assoc w R - Interim
embB	4245677	c.-837G>C	upstream_gene_variant	0.82	ethambutol
embA	4245693	p.Ile821Val	missense_variant	0.9	ethambutol
embB	4245737	c.-777A>C	upstream_gene_variant	1.0	ethambutol
embB	4245740	c.-774T>C	upstream_gene_variant	1.0	ethambutol
embB	4245764	c.-750G>C	upstream_gene_variant	1.0	ethambutol
embA	4245772	p.Asn847Thr	missense_variant	1.0	ethambutol
embA	4245785	c.2553G>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embA	4245807	c.2575_2577delTTAinsCG	frameshift_variant&missense_variant	1.0	ethambutol	Uncertain significance
embB	4245812	c.-702G>C	upstream_gene_variant	1.0	ethambutol
embA	4245813	c.2581_2583delCCCinsGG	frameshift_variant&missense_variant	1.0	ethambutol	Uncertain significance
embA	4245820	p.Ser863Thr	missense_variant	1.0	ethambutol
embB	4245824	c.-690G>C	upstream_gene_variant	1.0	ethambutol
embB	4245833	c.-681G>C	upstream_gene_variant	1.0	ethambutol
embB	4245842	c.-672G>C	upstream_gene_variant	1.0	ethambutol
embB	4245845	c.-669T>C	upstream_gene_variant	1.0	ethambutol
embB	4245851	c.-663G>C	upstream_gene_variant	1.0	ethambutol
embB	4245860	c.-654C>G	upstream_gene_variant	1.0	ethambutol
embB	4246064	c.-450T>C	upstream_gene_variant	0.85	ethambutol
embA	4246080	c.2848_2850delCCTinsTC	frameshift_variant&missense_variant	0.88	ethambutol	Uncertain significance
embA	4246088	c.2856A>G	synonymous_variant	0.91	ethambutol	Not assoc w R
embB	4246097	c.-417C>G	upstream_gene_variant	0.92	ethambutol
embA	4246103	c.2871C>G	synonymous_variant	0.92	ethambutol	Not assoc w R - Interim
embB	4246109	c.-405C>G	upstream_gene_variant	0.92	ethambutol
embB	4246115	c.-399T>G	upstream_gene_variant	0.91	ethambutol
embA	4246128	c.2896_2898delTCTinsAC	frameshift_variant&missense_variant	0.91	ethambutol	Uncertain significance
embA	4246138	p.Arg969Gln	missense_variant	0.95	ethambutol
embB	4246140	c.-374T>C	upstream_gene_variant	0.95	ethambutol
embA	4246143	p.Ile971Val	missense_variant	0.95	ethambutol
embA	4246151	c.2919A>G	synonymous_variant	0.95	ethambutol	Not assoc w R - Interim
embA	4246152	p.Ala974Gln	missense_variant	0.95	ethambutol
embB	4246157	c.-357A>G	upstream_gene_variant	0.95	ethambutol
embA	4246164	c.2932T>C	synonymous_variant	0.95	ethambutol	Not assoc w R - Interim
embB	4246184	c.-330A>C	upstream_gene_variant	0.96	ethambutol
embB	4246196	c.-318C>G	upstream_gene_variant	0.96	ethambutol
embB	4246205	c.-309A>G	upstream_gene_variant	0.96	ethambutol
embB	4246211	c.-303T>C	upstream_gene_variant	1.0	ethambutol
embB	4246217	c.-297G>A	upstream_gene_variant	1.0	ethambutol
embA	4246220	c.2988T>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4246223	c.-291C>T	upstream_gene_variant	1.0	ethambutol
embA	4246227	p.Ile999Val	missense_variant	1.0	ethambutol
embA	4246235	c.3003G>A	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embA	4246242	p.Gln1004Gly	missense_variant	1.0	ethambutol
embB	4246250	c.-264G>C	upstream_gene_variant	1.0	ethambutol
embB	4246256	c.-258G>T	upstream_gene_variant	1.0	ethambutol
embB	4246259	c.-255G>C	upstream_gene_variant	1.0	ethambutol
embA	4246264	p.His1011Arg	missense_variant	1.0	ethambutol
embB	4246292	c.-222A>G	upstream_gene_variant	1.0	ethambutol
embA	4246305	p.Ser1025Glu	missense_variant	1.0	ethambutol
embA	4246308	p.Thr1026Ala	missense_variant	1.0	ethambutol
embB	4246316	c.-198T>G	upstream_gene_variant	1.0	ethambutol
embB	4246319	c.-195G>C	upstream_gene_variant	0.96	ethambutol
embA	4246329	p.Thr1033Ala	missense_variant	1.0	ethambutol
embB	4246349	c.-165C>G	upstream_gene_variant	1.0	ethambutol
embA	4246359	c.3127_3129delGCCinsTG	frameshift_variant&missense_variant	1.0	ethambutol	Uncertain significance
embB	4246367	c.-147C>T	upstream_gene_variant	1.0	ethambutol
embB	4246373	c.-141T>C	upstream_gene_variant	1.0	ethambutol
embB	4246376	c.-138G>C	upstream_gene_variant	1.0	ethambutol
embA	4246379	c.3147C>T	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4247375	p.Leu288Val	missense_variant	1.0	ethambutol
embB	4247386	c.873T>C	synonymous_variant	1.0	ethambutol
embB	4247389	c.876C>G	synonymous_variant	1.0	ethambutol
embB	4247395	c.882C>G	synonymous_variant	1.0	ethambutol
embB	4247401	c.888T>C	synonymous_variant	1.0	ethambutol
embB	4247407	c.894G>C	synonymous_variant	1.0	ethambutol
embB	4247425	c.912G>C	synonymous_variant	1.0	ethambutol
embB	4247434	c.921C>G	synonymous_variant	1.0	ethambutol
embB	4247437	c.924A>G	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4247440	c.927C>G	synonymous_variant	1.0	ethambutol
embB	4247446	c.933C>T	synonymous_variant	1.0	ethambutol
embB	4247464	c.951C>G	synonymous_variant	1.0	ethambutol
embB	4247470	c.957T>C	synonymous_variant	1.0	ethambutol
embB	4247491	c.978G>C	synonymous_variant	1.0	ethambutol
embB	4247497	c.984T>C	synonymous_variant	1.0	ethambutol
embB	4247512	c.999T>C	synonymous_variant	1.0	ethambutol
embB	4247539	c.1026T>C	synonymous_variant	1.0	ethambutol
embB	4247554	c.1041T>C	synonymous_variant	1.0	ethambutol
embB	4247566	c.1053C>A	synonymous_variant	1.0	ethambutol
embB	4247572	c.1059A>G	synonymous_variant	1.0	ethambutol
embB	4247579	p.Ala356Phe	missense_variant	1.0	ethambutol
embB	4247587	c.1074G>A	synonymous_variant	1.0	ethambutol
embB	4247588	c.1075_1077delCTAinsAC	frameshift_variant&missense_variant	1.0	ethambutol
embB	4247603	c.1090C>T	synonymous_variant	1.0	ethambutol
embB	4247611	c.1098G>T	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4247614	c.1101T>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4247629	c.1116C>G	synonymous_variant	0.95	ethambutol
embB	4247632	c.1119C>G	synonymous_variant	0.95	ethambutol
embB	4247638	c.1125G>T	synonymous_variant	0.94	ethambutol
embB	4247646	p.Glu378Ala	missense_variant	0.92	ethambutol	Not assoc w R
embB	4247656	c.1143A>G	synonymous_variant	0.91	ethambutol
embB	4247659	c.1146C>G	synonymous_variant	0.91	ethambutol
embB	4247683	c.1170C>G	synonymous_variant	0.85	ethambutol
embB	4247692	c.1179C>G	synonymous_variant	0.88	ethambutol
embB	4247716	c.1203C>T	synonymous_variant	0.89	ethambutol
embB	4247722	c.1209G>C	synonymous_variant	0.89	ethambutol
embB	4247725	c.1212G>C	synonymous_variant	0.89	ethambutol
embB	4247729	p.Gly406Pro	missense_variant	0.89	ethambutol
embB	4247746	c.1233C>T	synonymous_variant	0.9	ethambutol
embB	4247761	c.1248T>C	synonymous_variant	0.92	ethambutol
embB	4247773	c.1260G>A	synonymous_variant	0.96	ethambutol
embB	4247776	c.1263G>T	synonymous_variant	0.96	ethambutol
embB	4247797	c.1284C>G	synonymous_variant	0.94	ethambutol
embB	4247800	c.1287A>T	synonymous_variant	0.94	ethambutol
embB	4247803	c.1290G>C	synonymous_variant	0.94	ethambutol
embB	4247815	c.1302C>G	synonymous_variant	0.92	ethambutol
embB	4247819	c.1306_1308delGTTinsAC	frameshift_variant&missense_variant	0.94	ethambutol
embB	4247830	c.1317A>G	synonymous_variant	0.94	ethambutol	Not assoc w R - Interim
embB	4247836	c.1323A>G	synonymous_variant	0.94	ethambutol	Not assoc w R - Interim
embB	4247839	c.1326G>C	synonymous_variant	0.94	ethambutol	Not assoc w R - Interim
embB	4247866	c.1353G>C	synonymous_variant	0.94	ethambutol
embB	4247875	c.1362G>C	synonymous_variant	0.94	ethambutol
embB	4247876	c.1363C>T	synonymous_variant	0.94	ethambutol
embB	4247881	c.1368G>C	synonymous_variant	0.94	ethambutol
embB	4247887	c.1374C>T	synonymous_variant	0.94	ethambutol	Not assoc w R - Interim
embB	4247893	c.1380C>T	synonymous_variant	0.93	ethambutol
embB	4247899	p.Met462Ile	missense_variant	0.93	ethambutol
embB	4247905	c.1392G>C	synonymous_variant	0.93	ethambutol	Not assoc w R - Interim
embB	4247909	c.1396T>C	synonymous_variant	0.92	ethambutol
embB	4247914	c.1401G>C	synonymous_variant	0.92	ethambutol	Not assoc w R - Interim
embB	4247932	c.1419C>G	synonymous_variant	0.95	ethambutol
embB	4247940	p.Leu476Trp	missense_variant	0.95	ethambutol
embB	4247945	c.1432T>C	synonymous_variant	0.95	ethambutol
embB	4247951	p.Ser480Ala	missense_variant	0.95	ethambutol
embB	4247956	c.1443G>C	synonymous_variant	0.95	ethambutol	Not assoc w R - Interim
embB	4247974	c.1461C>G	synonymous_variant	1.0	ethambutol
embB	4248007	c.1494C>G	synonymous_variant	1.0	ethambutol
embB	4248011	p.Ser500Arg	missense_variant	1.0	ethambutol
embB	4248014	p.Thr501Ala	missense_variant	1.0	ethambutol	Uncertain significance
embB	4248035	p.Val508Ile	missense_variant	1.0	ethambutol
embB	4248040	c.1527C>G	synonymous_variant	1.0	ethambutol
embB	4248041	p.Ala510Thr	missense_variant	1.0	ethambutol	Uncertain significance
embB	4248044	p.Lys511Ala	missense_variant	1.0	ethambutol
embB	4248070	c.1557T>C	synonymous_variant	0.95	ethambutol
embB	4248085	c.1572T>C	synonymous_variant	0.91	ethambutol
embB	4248097	c.1584C>G	synonymous_variant	0.91	ethambutol
embB	4248130	c.1617G>C	synonymous_variant	0.93	ethambutol
embB	4248142	c.1629T>C	synonymous_variant	0.93	ethambutol
embB	4248143	c.1630T>C	synonymous_variant	0.93	ethambutol
embB	4248157	c.1644A>G	synonymous_variant	0.94	ethambutol	Not assoc w R - Interim
embB	4248172	c.1659G>C	synonymous_variant	0.94	ethambutol
embB	4248199	c.1686A>G	synonymous_variant	0.94	ethambutol
embB	4248200	p.Ile563Val	missense_variant	0.94	ethambutol
embB	4248205	c.1692C>G	synonymous_variant	0.94	ethambutol
embB	4248206	c.1693_1695delAGCinsGT	frameshift_variant&missense_variant	0.94	ethambutol
embB	4248220	c.1707A>C	synonymous_variant	1.0	ethambutol
embB	4248304	c.1791G>C	synonymous_variant	1.0	ethambutol
embB	4248316	c.1803C>G	synonymous_variant	1.0	ethambutol
embB	4248319	c.1806A>G	synonymous_variant	1.0	ethambutol
embB	4248343	c.1830G>C	synonymous_variant	1.0	ethambutol
embB	4248350	c.1837T>C	synonymous_variant	1.0	ethambutol
embB	4248355	c.1842A>G	synonymous_variant	1.0	ethambutol
embB	4248358	c.1845C>G	synonymous_variant	1.0	ethambutol
embB	4248361	c.1848A>C	synonymous_variant	1.0	ethambutol
embB	4248362	p.Ser617Ala	missense_variant	1.0	ethambutol
embB	4248373	c.1860C>G	synonymous_variant	1.0	ethambutol
embB	4248382	c.1869C>G	synonymous_variant	1.0	ethambutol
embB	4248386	c.1873C>A	synonymous_variant	1.0	ethambutol
embB	4248407	c.1894_1896delTTAinsGG	frameshift_variant&missense_variant	1.0	ethambutol
embB	4248410	c.1897_1899delTTCinsCG	frameshift_variant&missense_variant	1.0	ethambutol
embB	4248419	p.Leu636Met	missense_variant	1.0	ethambutol
embB	4248425	c.1912T>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4248430	c.1917T>C	synonymous_variant	1.0	ethambutol
embB	4248432	p.Trp640Phe	missense_variant	1.0	ethambutol
embB	4248457	c.1944T>C	synonymous_variant	1.0	ethambutol
embB	4248472	c.1959T>C	synonymous_variant	1.0	ethambutol
embB	4249342	c.2829C>G	synonymous_variant	1.0	ethambutol
embB	4249348	c.2835G>C	synonymous_variant	1.0	ethambutol
embB	4249351	c.2838C>G	synonymous_variant	1.0	ethambutol
embB	4249369	c.2856T>C	synonymous_variant	1.0	ethambutol
embB	4249375	c.2862G>C	synonymous_variant	1.0	ethambutol
embB	4249381	c.2868A>G	synonymous_variant	1.0	ethambutol
embB	4249384	c.2871G>T	synonymous_variant	1.0	ethambutol
embB	4249417	c.2904A>G	synonymous_variant	1.0	ethambutol
embB	4249423	p.Asp970Glu	missense_variant	1.0	ethambutol	Uncertain significance
embB	4249424	p.Leu971Met	missense_variant	1.0	ethambutol
embB	4249429	c.2916C>T	synonymous_variant	1.0	ethambutol
embB	4249432	c.2919A>G	synonymous_variant	1.0	ethambutol
embB	4249441	c.2928A>G	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4249444	c.2931T>C	synonymous_variant	1.0	ethambutol
embB	4249469	p.Leu986Met	missense_variant	1.0	ethambutol
embB	4249486	c.2973T>G	synonymous_variant	1.0	ethambutol
embB	4249498	c.2985G>C	synonymous_variant	1.0	ethambutol
embB	4249521	p.Ala1003Val	missense_variant	1.0	ethambutol
embB	4249525	c.3012T>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embB	4249529	p.Ile1006Val	missense_variant	1.0	ethambutol
embB	4249532	p.Ala1007Thr	missense_variant	1.0	ethambutol	Uncertain significance
embB	4249537	c.3024A>G	synonymous_variant	1.0	ethambutol
embB	4249543	c.3030G>C	synonymous_variant	1.0	ethambutol
embB	4249546	c.3033G>A	synonymous_variant	1.0	ethambutol
embB	4249558	c.3045A>C	synonymous_variant	1.0	ethambutol
embB	4249568	p.Ser1019Thr	missense_variant	1.0	ethambutol
embB	4249573	c.3060T>C	synonymous_variant	1.0	ethambutol
embB	4249580	p.Leu1023Met	missense_variant	1.0	ethambutol
embB	4249594	c.3081G>C	synonymous_variant	1.0	ethambutol
aftB	4267241	c.1596G>C	synonymous_variant	1.0	ethambutol
aftB	4267244	c.1593T>C	synonymous_variant	1.0	ethambutol
aftB	4267256	c.1581C>G	synonymous_variant	1.0	ethambutol
aftB	4267262	c.1575T>C	synonymous_variant	1.0	ethambutol
aftB	4267266	p.Ala524Gly	missense_variant	0.91	ethambutol
aftB	4267268	c.1569T>C	synonymous_variant	0.91	ethambutol
aftB	4267274	c.1563G>C	synonymous_variant	0.91	ethambutol
aftB	4267289	p.Ala516Gln	missense_variant	0.83	ethambutol
aftB	4267292	c.1545C>G	synonymous_variant	0.83	ethambutol
aftB	4267297	c.1540T>C	synonymous_variant	0.83	ethambutol
aftB	4267301	c.1536C>T	synonymous_variant	0.83	ethambutol
aftB	4267304	p.Val511Ala	missense_variant	0.83	ethambutol
aftB	4267316	c.1521A>G	synonymous_variant	0.83	ethambutol
aftB	4267325	c.1512G>C	synonymous_variant	0.83	ethambutol
aftB	4267334	c.1503T>C	synonymous_variant	0.83	ethambutol	Not assoc w R - Interim
aftB	4267580	c.1257G>T	synonymous_variant	0.8	ethambutol