TB-Profiler result

Run: ERR4798504
Summary

Run ID: ERR4798504

Sample name:

Date: 2024-10-05T04:33:48.895458

Number of reads: 1995744

Percentage reads mapped: 66.37

Median coverage: 59.0

Strain: lineage3

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
La1.7.1 M.bovis None 0.08
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser431Cys Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol embB p.Ala356Val Uncertain significance Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761097 p.Ser431Cys missense_variant 0.16 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
embB 4247580 p.Ala356Val missense_variant 0.23 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 769 p.Ala257Ser missense_variant 0.83 isoniazid Uncertain significance
dnaA 777 c.777A>G synonymous_variant 0.17 isoniazid
dnaA 792 c.792C>T synonymous_variant 0.18 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCTT synonymous_variant 0.19 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.23 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.21 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.19 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.19 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.19 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.19 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.19 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 876 c.876C>G synonymous_variant 0.17 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.18 isoniazid
dnaA 891 c.891C>T synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 897 c.897A>G synonymous_variant 0.17 isoniazid
dnaA 903 c.903C>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 909 c.909A>G synonymous_variant 0.17 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.15 isoniazid
dnaA 936 c.936C>G synonymous_variant 0.18 isoniazid
dnaA 939 c.939C>G synonymous_variant 0.17 isoniazid
dnaA 942 c.942C>G synonymous_variant 0.17 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.17 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.2 isoniazid
dnaA 990 c.990A>C synonymous_variant 0.15 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.17 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 1020 c.1020C>G synonymous_variant 0.17 isoniazid
dnaA 1023 c.1023C>T synonymous_variant 0.18 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.18 isoniazid
dnaA 1029 c.1029C>T synonymous_variant 0.19 isoniazid
dnaA 1050 c.1050G>C synonymous_variant 0.18 isoniazid
gyrB 6172 c.933C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6253 c.1014G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6280 c.1041T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6316 c.-986G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6358 c.1119C>G synonymous_variant 0.17 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6361 c.-941G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6362 c.-940_-938delTTGinsCTC upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6955 c.-347G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7153 c.-149G>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7433 c.132G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7502 c.201C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7526 c.225G>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7643 c.342C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7646 c.345C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7655 c.354G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7700 c.399G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7706 c.405C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7725 c.424C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7769 c.468C>T synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7793 c.492G>A synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7797 c.496_498delCTAinsTTG synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7820 c.519G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7868 c.567C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8192 c.891C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8201 c.900C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8222 c.921C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8225 c.924T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8231 c.930C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCTG synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8486 c.1185T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8492 c.1191G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8520 c.1219C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8535 p.Glu412Gln missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8555 c.1254G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8585 c.1284C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8694 c.1393C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8729 c.1428T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8888 c.1587C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8933 c.1632G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8936 c.1635G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8983 p.Cys561Ser missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9003 c.1702C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9038 c.1737C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9101 c.1800A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9104 c.1803C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9266 c.1965C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 p.Asp669Glu missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9315 c.2014C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9326 c.2025G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9782 c.2481C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 490899 c.117C>T synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 490905 c.123T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 490911 c.129T>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 490921 p.Gln47Glu missense_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 490929 c.147C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 490932 c.150T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 490948 p.Ser56Ala missense_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 490971 c.189A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 490974 c.192T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 490980 p.Asn66Lys missense_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 490983 c.201G>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 490988 p.Leu69Gln missense_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 490995 c.213C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 490998 c.216T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491007 c.225G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575695 c.348C>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ethionamide
mshA 575704 c.357T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.18 isoniazid
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.24 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.29 isoniazid
ethionamide
mshA 575767 c.420G>A synonymous_variant 0.26 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.26 isoniazid
ethionamide
mshA 575779 p.Glu144Asp missense_variant 0.25 isoniazid
ethionamide
mshA 575780 p.Pro145Ala missense_variant 0.25 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.23 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.23 isoniazid
ethionamide
mshA 575842 c.495G>C synonymous_variant 0.25 isoniazid
ethionamide
mshA 575845 c.498C>G synonymous_variant 0.26 isoniazid
ethionamide
mshA 575848 c.501C>T synonymous_variant 0.25 isoniazid
ethionamide
mshA 575851 c.504C>G synonymous_variant 0.25 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575887 c.540G>T synonymous_variant 0.17 isoniazid
ethionamide
ccsA 619507 c.-384A>G upstream_gene_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620307 c.417C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620652 c.762C>G synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620661 c.771C>G synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620685 c.795G>A synonymous_variant 0.25 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin
ccsA 620698 p.Val270Ile missense_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620712 c.822G>C synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620715 c.825C>T synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>A synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620742 c.852G>C synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>C synonymous_variant 0.24 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657189 c.282C>A synonymous_variant 0.17 ethionamide
Rv0565c 657193 p.Met93Thr missense_variant 0.16 ethionamide
Rv0565c 657196 p.Asp92Ala missense_variant 0.18 ethionamide
Rv0565c 657200 p.Thr91Ala missense_variant 0.19 ethionamide Uncertain significance
Rv0565c 657210 c.261C>T synonymous_variant 0.17 ethionamide Not assoc w R - Interim
Rv0565c 657213 c.258C>T synonymous_variant 0.17 ethionamide
Rv0565c 657219 p.Ala84Val missense_variant 0.19 ethionamide
Rv0565c 657233 p.Ile80Val missense_variant 0.18 ethionamide
Rv0565c 657240 p.Glu77Lys missense_variant 0.17 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.17 ethionamide
Rv0565c 657725 c.-255G>A upstream_gene_variant 0.27 ethionamide
Rv0565c 657732 c.-263_-262delAGinsGA upstream_gene_variant 0.24 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.24 ethionamide
hadA 731686 c.-244_-243insATGT upstream_gene_variant 0.2 isoniazid
hadA 731689 c.-240_-237delAGAC upstream_gene_variant 0.2 isoniazid
hadA 731695 c.-235C>T upstream_gene_variant 0.2 isoniazid
hadA 731698 c.-232T>G upstream_gene_variant 0.2 isoniazid
hadA 731708 c.-222G>A upstream_gene_variant 0.27 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.27 isoniazid
hadA 731726 c.-204C>G upstream_gene_variant 0.37 isoniazid
hadA 731729 c.-201C>T upstream_gene_variant 0.37 isoniazid
hadA 731753 c.-177A>C upstream_gene_variant 0.35 isoniazid
hadA 731756 c.-174C>T upstream_gene_variant 0.35 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.25 isoniazid
hadA 731786 c.-144C>G upstream_gene_variant 0.25 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.26 isoniazid
hadA 731807 c.-123C>T upstream_gene_variant 0.21 isoniazid
hadA 731819 c.-111G>C upstream_gene_variant 0.21 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.21 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.2 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.2 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.21 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.21 isoniazid
nusG 734451 c.198G>C synonymous_variant 0.19 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.19 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734478 c.225C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.19 rifampicin
nusG 734520 c.267C>A synonymous_variant 0.19 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.19 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.17 rifampicin
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760058 c.252C>G synonymous_variant 0.17 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.2 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760109 c.303C>T synonymous_variant 0.28 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.28 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.25 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.26 rifampicin
rpoB 760145 c.339C>G synonymous_variant 0.27 rifampicin
rpoB 760181 c.375T>A synonymous_variant 0.24 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.23 rifampicin
rpoB 760295 c.489C>T synonymous_variant 0.25 rifampicin
rpoB 760307 c.501T>C synonymous_variant 0.24 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.24 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.25 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.24 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.25 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760358 c.552C>G synonymous_variant 0.25 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.24 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.2 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.2 rifampicin
rpoB 760520 c.714C>G synonymous_variant 0.16 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.23 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.25 rifampicin
rpoB 760601 c.795C>T synonymous_variant 0.23 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760622 c.816C>T synonymous_variant 0.22 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.16 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.17 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.18 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.18 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.21 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.2 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.22 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.22 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.23 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.22 rifampicin
rpoB 760856 c.1050C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>G synonymous_variant 0.29 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.28 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.27 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.28 rifampicin
rpoB 760937 c.1131G>A synonymous_variant 0.29 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.25 rifampicin
rpoB 760982 c.1176G>T synonymous_variant 0.23 rifampicin
rpoB 760985 c.1179G>T synonymous_variant 0.23 rifampicin
rpoB 760991 c.1185G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>T synonymous_variant 0.23 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.22 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.2 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.17 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761240 c.1434C>T synonymous_variant 0.19 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>C synonymous_variant 0.22 rifampicin
rpoB 761261 c.1455G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.29 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>T synonymous_variant 0.33 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.35 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.33 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.33 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.28 rifampicin
rpoB 761432 c.1626C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761435 c.1629T>C synonymous_variant 0.27 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.25 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.26 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.25 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.24 rifampicin
rpoB 761465 c.1659G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761471 c.1665C>T synonymous_variant 0.23 rifampicin
rpoB 761477 c.1671C>T synonymous_variant 0.23 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.25 rifampicin
rpoB 761504 c.1698C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.25 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.27 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.22 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.21 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.23 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.18 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.17 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.24 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.26 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.25 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.25 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.24 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.22 rifampicin
rpoB 761828 c.2022C>T synonymous_variant 0.22 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.3 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.3 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.22 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.22 rifampicin
rpoB 761913 p.Asp703Gln missense_variant 0.23 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.23 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.24 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.3 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.38 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.38 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.36 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.29 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.27 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>T synonymous_variant 0.29 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.29 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.28 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.29 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.32 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.3 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.29 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.31 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.32 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.3 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.32 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.3 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.3 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.32 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762431 c.2625C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762434 c.2628T>G synonymous_variant 0.71 rifampicin Not assoc w R
rpoB 762449 c.2643C>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.22 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.22 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762818 c.3012C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762833 c.3027C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762902 c.-468C>T upstream_gene_variant 0.31 rifampicin
rpoC 762917 c.-453C>T upstream_gene_variant 0.3 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>G upstream_gene_variant 0.27 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.3 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.23 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.18 rifampicin
rpoC 763205 c.-165G>T upstream_gene_variant 0.18 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.18 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.16 rifampicin
rpoC 763241 c.-129G>A upstream_gene_variant 0.16 rifampicin
rpoC 763402 c.33C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.18 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.25 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.32 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.35 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.22 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763726 c.357C>T synonymous_variant 0.17 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.17 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.2 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.21 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763771 c.402C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763780 c.411C>G synonymous_variant 0.23 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.22 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.21 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763836 p.Ala156Val missense_variant 0.2 rifampicin
rpoC 763851 p.Ala161Gly missense_variant 0.25 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.27 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.28 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.29 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.29 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.29 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.31 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.3 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.31 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.35 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.34 rifampicin
rpoC 763951 c.582G>A synonymous_variant 0.37 rifampicin
rpoC 763963 c.594C>G synonymous_variant 0.33 rifampicin
rpoC 763967 p.Gly200Ser missense_variant 0.35 rifampicin
rpoC 763972 c.603C>T synonymous_variant 0.35 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.34 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.31 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.31 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.31 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.3 rifampicin
rpoC 764044 c.675T>G synonymous_variant 0.3 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.29 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.31 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764159 c.790C>T synonymous_variant 0.28 rifampicin
rpoC 764167 c.798G>A synonymous_variant 0.27 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.26 rifampicin
rpoC 764215 c.846A>C synonymous_variant 0.25 rifampicin
rpoC 764218 c.849C>T synonymous_variant 0.26 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>A synonymous_variant 0.26 rifampicin
rpoC 764246 c.877_879delCTCinsTTG synonymous_variant 0.26 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.29 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.3 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.33 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.28 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.18 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.22 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.28 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.41 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.37 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.41 rifampicin
rpoC 764605 c.1236G>A synonymous_variant 0.4 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764686 c.1317C>T synonymous_variant 0.29 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764782 c.1413C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.34 rifampicin
rpoC 764803 c.1434C>G synonymous_variant 0.34 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.33 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCTC synonymous_variant 0.28 rifampicin
rpoC 764896 c.1527C>T synonymous_variant 0.3 rifampicin
rpoC 764902 c.1533C>T synonymous_variant 0.32 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.3 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.25 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765013 c.1644C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1686delTCCinsAGT synonymous_variant 0.21 rifampicin
rpoC 765065 c.1696C>T synonymous_variant 0.2 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.2 rifampicin
rpoC 765079 c.1710T>C synonymous_variant 0.2 rifampicin
rpoC 765082 c.1713G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765121 c.1752G>T synonymous_variant 0.15 rifampicin
rpoC 765367 c.1998C>G synonymous_variant 0.17 rifampicin
rpoC 765370 c.2001G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.21 rifampicin Uncertain significance
rpoC 765391 c.2022C>T synonymous_variant 0.22 rifampicin
rpoC 765406 c.2037G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765409 c.2040T>C synonymous_variant 0.23 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.24 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Ser missense_variant 0.28 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.25 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.31 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765517 c.2148C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.33 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.35 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.33 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.36 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.37 rifampicin
rpoC 765622 p.Glu751Asp missense_variant 0.4 rifampicin
rpoC 765625 c.2256C>T synonymous_variant 0.38 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765670 c.2301C>T synonymous_variant 0.41 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765728 p.Gln787Lys missense_variant 0.41 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765752 p.Asp795Ser missense_variant 0.41 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.33 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.37 rifampicin
rpoC 765790 c.2421C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765793 c.2424C>G synonymous_variant 0.36 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.36 rifampicin
rpoC 765814 c.2445A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.27 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.26 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.3 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.31 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.37 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.34 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.26 rifampicin
rpoC 766093 c.2724C>A synonymous_variant 0.24 rifampicin
rpoC 766095 p.Thr909Ser missense_variant 0.23 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.21 rifampicin
rpoC 766123 c.2754C>A synonymous_variant 0.2 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.16 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.17 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.17 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.19 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.25 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.31 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.31 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.32 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.39 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.39 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.38 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.4 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.41 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.38 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.37 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.37 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.38 rifampicin
rpoC 766660 c.3291G>A synonymous_variant 0.32 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.27 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.29 rifampicin
rpoC 766700 c.3331C>T synonymous_variant 0.31 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.33 rifampicin
rpoC 766733 c.3364C>T synonymous_variant 0.33 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.32 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.33 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.36 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.37 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766801 c.3432C>G synonymous_variant 0.34 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.43 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766883 p.Ser1172Ala missense_variant 0.4 rifampicin Uncertain significance
rpoC 766894 c.3525T>C synonymous_variant 0.36 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.36 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.36 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.36 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.42 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>G synonymous_variant 0.34 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.25 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.2 rifampicin
rpoC 767158 c.3789T>A synonymous_variant 0.29 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.3 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775981 p.Leu834Met missense_variant 0.15 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.18 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.17 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.23 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.28 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.28 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.28 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.27 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.25 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.28 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.27 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.29 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>G synonymous_variant 0.28 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.29 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.28 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.3 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781859 c.300T>G synonymous_variant 0.26 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.24 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.23 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.23 streptomycin
rpsL 781883 c.324G>A synonymous_variant 0.26 streptomycin
rpsL 781886 c.327C>T synonymous_variant 0.26 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.25 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.24 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.23 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.23 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.22 streptomycin
rplC 800540 c.-269T>C upstream_gene_variant 0.21 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.21 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.27 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.27 linezolid
rplC 800582 c.-227C>T upstream_gene_variant 0.28 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.27 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.28 linezolid
rplC 800621 c.-188G>A upstream_gene_variant 0.26 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.29 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.33 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.32 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.22 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.24 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.23 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.23 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.24 linezolid
rplC 800744 c.-65G>C upstream_gene_variant 0.23 linezolid
rplC 800745 c.-64_-62delCTCinsTTG upstream_gene_variant 0.23 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.25 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.24 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303488 c.558G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303506 c.576C>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303512 c.582T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303534 p.Ser202Ala missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303538 p.Arg203Leu missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303578 c.648G>A synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303584 c.654C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303596 c.666G>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303605 c.675C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303608 c.678G>A synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303617 c.687C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303620 c.690C>T synonymous_variant 0.26 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303629 c.699C>T synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303659 c.729T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303661 p.Val244Ala missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303674 c.744C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303686 c.756C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303729 c.799_801delCTAinsTTG synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303750 c.820_822delTTAinsCTG synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303755 c.825T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303779 c.849G>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303782 c.852C>T synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303788 c.858T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303800 c.870G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303812 c.882C>T synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303825 p.Glu299Gln missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303844 p.Ala305Gly missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303869 c.939T>C synonymous_variant 0.16 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303911 c.981G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303913 p.Gly328Asp missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303923 c.993C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304481 c.1551T>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304496 c.1566T>A synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304499 c.1569T>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1304502 c.1572G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304526 c.1596T>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304532 c.1602G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304533 c.1603T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304541 c.1611C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304544 c.1614T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304546 p.Val539Ala missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304574 c.1644C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304610 c.1680C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>A synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304934 c.2004C>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304946 c.2016G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1305364 p.Met812Leu missense_variant 0.9 pretomanid
delamanid
clofazimine
sigE 1364703 c.291G>C synonymous_variant 0.23 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.21 pyrazinamide
sigE 1364721 c.309C>G synonymous_variant 0.2 pyrazinamide
sigE 1364726 p.Asn105Ser missense_variant 0.22 pyrazinamide
sigE 1364733 p.His107Gln missense_variant 0.2 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.2 pyrazinamide
sigE 1364745 c.333C>T synonymous_variant 0.2 pyrazinamide
sigE 1364746 c.334C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
sigE 1364751 c.339C>G synonymous_variant 0.19 pyrazinamide
sigE 1364760 c.348C>G synonymous_variant 0.21 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.21 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.23 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.27 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.3 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.34 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.33 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.35 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.3 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.29 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.25 pyrazinamide
sigE 1364868 c.456T>C synonymous_variant 0.28 pyrazinamide
sigE 1364871 c.459C>G synonymous_variant 0.28 pyrazinamide
sigE 1364874 c.462C>T synonymous_variant 0.28 pyrazinamide
sigE 1364883 c.471G>A synonymous_variant 0.3 pyrazinamide
sigE 1364889 c.477A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
sigE 1364892 c.480C>G synonymous_variant 0.29 pyrazinamide
sigE 1364913 c.501C>G synonymous_variant 0.33 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.32 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.34 pyrazinamide
sigE 1364928 c.516C>T synonymous_variant 0.34 pyrazinamide
sigE 1364952 c.540A>C synonymous_variant 0.26 pyrazinamide
sigE 1364958 c.546G>C synonymous_variant 0.21 pyrazinamide
sigE 1364961 c.549A>G synonymous_variant 0.22 pyrazinamide
sigE 1364964 c.552T>G synonymous_variant 0.21 pyrazinamide
sigE 1364967 c.555C>T synonymous_variant 0.21 pyrazinamide
sigE 1364973 c.561G>A synonymous_variant 0.2 pyrazinamide
sigE 1364976 c.564T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
sigE 1364984 p.Ala191Asp missense_variant 0.19 pyrazinamide
sigE 1364988 c.576G>A synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
sigE 1365003 c.591T>C synonymous_variant 0.19 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.19 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>T non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.35 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.3 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473831 n.174G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474447 n.790G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475453 n.1796T>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475487 n.1830C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2103C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.43 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475999 n.2342G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476047 n.2390G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673758 c.-444A>G upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673784 c.-418G>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673793 c.-409G>A upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1673799 c.-403T>C upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673802 c.-400A>G upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673808 c.-394A>G upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673841 c.-361A>G upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1673856 c.-346T>G upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673877 c.-325C>T upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1674745 p.Tyr182Ala missense_variant 0.19 isoniazid
ethionamide
inhA 1674756 c.555T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674765 c.564C>T synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674774 c.573A>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674777 c.576C>A synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674792 c.591G>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674820 c.619_621delCTCinsTTG synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674828 c.627G>A synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.28 isoniazid
ethionamide
inhA 1674870 c.669T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674876 c.675C>G synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674879 c.678T>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674888 c.687C>T synonymous_variant 0.16 isoniazid
ethionamide
rpsA 1833532 c.-10A>C upstream_gene_variant 0.18 pyrazinamide
rpsA 1833568 c.27G>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.34 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.32 pyrazinamide
rpsA 1833613 c.72C>A synonymous_variant 0.35 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.35 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1833790 c.249T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.25 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.26 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.3 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.29 pyrazinamide
rpsA 1833895 c.354G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833964 c.423C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1833970 c.429G>A synonymous_variant 0.28 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.17 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.29 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.25 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.26 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.27 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.28 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.33 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.32 pyrazinamide
rpsA 1834603 c.1062G>A synonymous_variant 0.28 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834633 c.1092A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834699 p.Glu386Asp missense_variant 0.24 pyrazinamide
tsnR 1853369 c.-237C>T upstream_gene_variant 0.31 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.32 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.31 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.32 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.32 linezolid
tsnR 1853393 c.-213C>T upstream_gene_variant 0.33 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.33 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.34 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.32 linezolid
tsnR 1853441 c.-165C>G upstream_gene_variant 0.33 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.31 linezolid
tsnR 1853450 c.-156G>A upstream_gene_variant 0.29 linezolid
tsnR 1853453 c.-153G>C upstream_gene_variant 0.28 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.28 linezolid
tsnR 1853468 c.-138C>G upstream_gene_variant 0.28 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.24 linezolid
tsnR 1853481 c.-125A>G upstream_gene_variant 0.21 linezolid
tsnR 1853485 c.-121G>C upstream_gene_variant 0.2 linezolid
tsnR 1853493 c.-113G>A upstream_gene_variant 0.18 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.95 pyrazinamide Not assoc w R
PPE35 2169208 c.1404delC frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
kasA 2517941 c.-174C>G upstream_gene_variant 0.25 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.23 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.26 isoniazid
kasA 2517965 c.-150C>T upstream_gene_variant 0.25 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.25 isoniazid
kasA 2517983 c.-132T>C upstream_gene_variant 0.22 isoniazid
kasA 2517989 c.-126T>G upstream_gene_variant 0.22 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.2 isoniazid
kasA 2518594 c.480C>T synonymous_variant 0.17 isoniazid
kasA 2518597 c.483C>G synonymous_variant 0.17 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.17 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.17 isoniazid
kasA 2518636 c.522C>A synonymous_variant 0.2 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.19 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.19 isoniazid
kasA 2518645 c.531G>C synonymous_variant 0.19 isoniazid
kasA 2518651 c.537C>G synonymous_variant 0.19 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.18 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.17 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.16 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.18 isoniazid
kasA 2518717 c.603C>G synonymous_variant 0.16 isoniazid
kasA 2518735 c.621C>T synonymous_variant 0.2 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.19 isoniazid
kasA 2519112 p.Gln333Arg missense_variant 0.2 isoniazid
kasA 2519119 c.1005G>C synonymous_variant 0.22 isoniazid
kasA 2519134 c.1020G>A synonymous_variant 0.22 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.22 isoniazid
kasA 2519140 c.1026G>A synonymous_variant 0.21 isoniazid
kasA 2519146 c.1032C>A synonymous_variant 0.21 isoniazid
kasA 2519152 c.1038G>C synonymous_variant 0.23 isoniazid
kasA 2519161 c.1047G>A synonymous_variant 0.2 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.17 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 1.0 kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R
Rv2477c 2783410 c.633G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783419 c.624G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783458 c.585G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.23 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783535 c.508C>T synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>A synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783578 c.465G>A synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783602 c.441G>A synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783623 c.420G>A synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783632 c.411C>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.17 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783788 c.255T>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783806 c.237G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>T synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783956 p.Tyr29Phe missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.25 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783968 c.75G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.26 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2752c 3065040 c.1150_1152delCTCinsTTG synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065049 c.1143G>A synonymous_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065055 c.1137T>G synonymous_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065064 c.1128G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065070 c.1122C>A synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065073 c.1119C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065085 c.1105_1107delAGGinsCGC synonymous_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065097 c.1095C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065109 c.1081_1083delAGAinsCGG synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065130 c.1062A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065133 c.1059T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065142 c.1050A>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.36 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065154 c.1038G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065979 c.213T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065993 p.Val67Ile missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065997 c.195C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066002 p.Met64Leu missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066006 c.186G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066017 c.175C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066024 c.168T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066365 c.-174C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066366 c.-175C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066387 c.-196G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066420 c.-229C>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066423 c.-232C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066426 c.-235T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066429 c.-238G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066432 c.-241T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066437 c.-246G>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066459 c.-268T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066465 c.-276_-274delGGGinsAGC upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066471 c.-280A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066474 c.-283G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066477 c.-286C>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066480 c.-291_-289delGCCinsTCT upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066483 c.-292T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066513 c.-322C>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066527 c.-336C>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066543 c.-352C>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066560 c.-369C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066567 c.-376C>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066612 c.-421G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066617 c.-426G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066618 c.-427A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067661 c.285C>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067676 c.270C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067679 p.Cys89Leu missense_variant 0.18 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067693 p.Ile85Val missense_variant 0.19 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.18 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.18 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067841 c.105G>T synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067886 c.60A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067949 c.-4C>T upstream_gene_variant 0.93 para-aminosalicylic_acid
thyA 3073854 c.618C>T synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073888 p.Ser195Glu missense_variant 0.18 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073905 c.567C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073944 c.528C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073968 c.504C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.19 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
whiB7 3568857 c.-178C>T upstream_gene_variant 1.0 kanamycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
streptomycin Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625117 c.-207T>G upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625123 c.-213T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625147 c.-237C>G upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625690 c.-780T>G upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625699 c.915C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625717 c.-807C>T upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625747 c.867G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625783 c.-873C>T upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625801 c.-891G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626332 c.282T>C synonymous_variant 0.19 rifampicin
bedaquiline
mtrB 3626344 c.270G>C synonymous_variant 0.21 rifampicin
bedaquiline
mtrB 3626349 p.Ser89Gly missense_variant 0.2 rifampicin
bedaquiline
mtrB 3626353 c.261C>G synonymous_variant 0.24 rifampicin
bedaquiline
mtrB 3626362 c.252A>C synonymous_variant 0.25 rifampicin
bedaquiline
mtrB 3626368 c.246G>A synonymous_variant 0.3 rifampicin
bedaquiline
mtrB 3626377 p.Asp79Glu missense_variant 0.31 rifampicin
bedaquiline
mtrB 3626383 p.Ala77Gly missense_variant 0.33 rifampicin
bedaquiline
mtrB 3626389 p.Arg75Lys missense_variant 0.34 rifampicin
bedaquiline
mtrB 3626400 p.Ile72Val missense_variant 0.29 rifampicin
bedaquiline
mtrB 3626404 c.210C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3626407 c.207C>G synonymous_variant 0.32 rifampicin
bedaquiline
mtrB 3626437 c.177T>C synonymous_variant 0.27 rifampicin
bedaquiline
mtrB 3626443 c.171T>G synonymous_variant 0.26 rifampicin
bedaquiline
mtrB 3626451 c.163C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626455 c.159C>G synonymous_variant 0.18 rifampicin
bedaquiline
mtrB 3626461 c.153A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626470 c.144A>C synonymous_variant 0.15 rifampicin
bedaquiline
mtrB 3626723 c.-110C>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626750 c.-137T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626773 c.-160C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3626777 c.573C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626780 c.-167T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626798 c.-185T>A upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626825 c.525T>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626843 c.-230G>A upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626849 c.-236C>T upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626885 c.-272A>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626924 c.-311G>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626927 c.-314G>A upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3626933 c.-320C>T upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3626954 c.-341C>G upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3626957 c.-344G>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3626969 c.-356C>G upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3626996 c.-383G>A upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627023 c.-410C>G upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrB 3627059 c.-446G>C upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627101 c.-488C>G upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627110 c.-497G>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3627137 c.-526_-524delTTGinsCTA upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrB 3627143 c.-530G>C upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3627187 c.163T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627197 c.-584T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627203 c.-590C>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627212 c.-599C>T upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3627218 c.-605G>C upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3627233 c.-620T>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3627239 c.111C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627272 c.-659G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
rpoA 3877587 c.921A>C synonymous_variant 0.23 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.27 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.28 rifampicin
rpoA 3877638 c.870T>G synonymous_variant 0.28 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877677 p.Ala277Ser missense_variant 0.21 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877685 c.823C>T synonymous_variant 0.2 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.31 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877758 c.750G>C synonymous_variant 0.3 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877815 c.693C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877851 c.657C>T synonymous_variant 0.32 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.33 rifampicin
rpoA 3877865 c.643C>T synonymous_variant 0.26 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.27 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>C synonymous_variant 0.27 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.21 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.22 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878295 c.213A>G synonymous_variant 0.2 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.23 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>C synonymous_variant 0.23 rifampicin
rpoA 3878334 c.174T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.22 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.25 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.23 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.22 rifampicin
rpoA 3878384 c.124C>T synonymous_variant 0.24 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.24 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878418 c.90C>T synonymous_variant 0.24 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.18 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.16 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.18 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.19 rifampicin
rpoA 3878836 c.-329G>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878842 c.-335G>C upstream_gene_variant 0.27 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.25 rifampicin
rpoA 3878869 c.-362G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878881 c.-374C>G upstream_gene_variant 0.29 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.31 rifampicin
rpoA 3878894 c.-387A>G upstream_gene_variant 0.31 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.34 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878923 c.-417_-416delGCinsCG upstream_gene_variant 0.37 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878953 c.-446C>G upstream_gene_variant 0.39 rifampicin
rpoA 3878962 c.-455G>A upstream_gene_variant 0.34 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3879037 c.-530G>A upstream_gene_variant 0.31 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.29 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.24 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879117 c.-610C>T upstream_gene_variant 0.31 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.29 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879145 c.-638G>C upstream_gene_variant 0.26 rifampicin
rpoA 3879148 c.-641G>C upstream_gene_variant 0.25 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879178 c.-671T>G upstream_gene_variant 0.2 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.18 rifampicin
clpC1 4038425 c.2280C>A synonymous_variant 0.15 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.16 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.19 pyrazinamide
clpC1 4038491 c.2214C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038502 p.Ile735Val missense_variant 0.21 pyrazinamide
clpC1 4038508 c.2197C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038518 c.2187G>T synonymous_variant 0.21 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.18 pyrazinamide
clpC1 4038537 p.Thr723Ser missense_variant 0.18 pyrazinamide
clpC1 4038539 c.2166G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038569 c.2136C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038620 c.2085G>A synonymous_variant 0.18 pyrazinamide
clpC1 4038692 c.2013C>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038698 c.2007C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038773 c.1932T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038809 c.1896G>A synonymous_variant 0.22 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038875 c.1830C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038893 c.1812C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.33 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039025 c.1680C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.16 pyrazinamide
clpC1 4039112 c.1593C>A synonymous_variant 0.16 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.2 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039193 c.1512C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039223 c.1482C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039238 c.1467C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039243 c.1462C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039259 c.1446G>A synonymous_variant 0.24 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.16 pyrazinamide
clpC1 4039484 c.1221T>G synonymous_variant 0.16 pyrazinamide
clpC1 4039508 c.1197G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039526 c.1179G>A synonymous_variant 0.27 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039553 c.1152C>A synonymous_variant 0.29 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.31 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039583 c.1122C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039748 c.957G>A synonymous_variant 0.25 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.19 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039832 c.873C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.25 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039955 c.750G>T synonymous_variant 0.23 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039964 c.741C>T synonymous_variant 0.26 pyrazinamide
clpC1 4040000 c.705C>T synonymous_variant 0.34 pyrazinamide
clpC1 4040015 c.690G>A synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040021 c.684A>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.35 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.35 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.31 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040213 p.Ser164Thr missense_variant 0.16 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040309 c.396C>T synonymous_variant 0.27 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.21 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.22 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040419 c.286C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040426 c.279T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040495 c.210C>A synonymous_variant 0.21 pyrazinamide
clpC1 4040537 c.168G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.27 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040588 c.117T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040591 c.114C>T synonymous_variant 0.2 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCTG synonymous_variant 0.24 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.23 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.22 pyrazinamide
panD 4044023 c.259C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
panD 4044872 c.-591C>T upstream_gene_variant 0.93 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 0.88 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4138670 c.1086G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138681 p.Met359Val missense_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138682 c.1074C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240642 c.780G>C synonymous_variant 0.16 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.16 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.17 ethambutol
embC 4240660 c.798C>G synonymous_variant 0.18 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.18 ethambutol Not assoc w R
embC 4240678 c.816T>C synonymous_variant 0.19 ethambutol
embC 4240681 c.819G>C synonymous_variant 0.19 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.19 ethambutol
embC 4240690 c.828G>C synonymous_variant 0.17 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.17 ethambutol
embC 4240698 p.Ala279Gly missense_variant 0.17 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4240729 c.867C>G synonymous_variant 0.19 ethambutol
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242309 p.Thr816Ile missense_variant 1.0 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245125 c.1893G>C synonymous_variant 0.18 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.22 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.21 ethambutol
embB 4247506 c.993C>G synonymous_variant 0.25 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.25 ethambutol
embB 4247527 c.1014G>C synonymous_variant 0.21 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.2 ethambutol
embB 4247550 p.Ala346Asp missense_variant 0.21 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.22 ethambutol
embB 4247566 c.1053C>G synonymous_variant 0.23 ethambutol
embB 4247572 c.1059A>C synonymous_variant 0.21 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.16 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.15 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.22 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.19 ethambutol
embB 4248118 c.1605T>G synonymous_variant 0.18 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.17 ethambutol
embB 4248190 c.1677G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248200 p.Ile563Val missense_variant 0.18 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.17 ethambutol Uncertain significance
embB 4248211 c.1698G>A synonymous_variant 0.16 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R