TB-Profiler result

Run: SRR7496509
Summary

Run ID: SRR7496509

Sample name:

Date: 2024-10-04T15:35:22.993752

Number of reads: 461249

Percentage reads mapped: 52.94

Median coverage: 19.0

Strain:

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.2.1.2 Indo-Oceanic RD239 0.85
La1.2.BCG M.bovis None 0.07
lineage1.2.1.2.1 Indo-Oceanic RD239 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Leu359Ile Uncertain significance Mutation from literature
p.Asn399Asp Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance Mutation from literature
embB 4247588 p.Leu359Ile missense_variant 0.41 ethambutol Uncertain significance Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.44 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 30 c.30C>G synonymous_variant 0.42 isoniazid
dnaA 42 c.42C>T synonymous_variant 0.38 isoniazid
dnaA 612 c.612G>C synonymous_variant 0.33 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.36 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 649 c.649C>T synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.42 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.42 isoniazid
dnaA 669 c.669C>T synonymous_variant 0.38 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.36 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.43 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.48 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.52 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.5 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.54 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.5 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.46 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.48 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.48 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.41 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.5 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCTC synonymous_variant 0.46 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.46 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.42 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.42 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.42 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.46 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.46 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.42 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.39 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.45 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.45 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.5 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.54 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.57 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.55 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.54 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.54 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.56 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.43 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.43 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.39 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.39 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.37 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.38 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.38 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.42 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.37 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.37 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.36 isoniazid
dnaA 1003 c.1003C>T synonymous_variant 0.37 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.39 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.42 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.43 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.43 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.44 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.48 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.46 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.47 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.45 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.49 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.49 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.49 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.51 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.5 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.5 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.5 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.48 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.48 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.53 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.52 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.52 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.52 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.52 isoniazid
dnaA 1218 c.1218C>G synonymous_variant 0.51 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.51 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.53 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.5 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.47 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.47 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.45 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.52 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.44 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.44 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.41 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.41 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 1302 c.1302C>A synonymous_variant 0.56 isoniazid Not assoc w R
dnaA 1311 c.1311C>G synonymous_variant 0.41 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.39 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.39 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.39 isoniazid
dnaA 1323 c.1323C>T synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 1332 c.1332A>C synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.41 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.32 isoniazid
gyrB 6112 p.Met291Ile missense_variant 0.93 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6238 c.999G>A synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.38 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>A upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6889 c.-413G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6898 c.-404G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>G upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.76 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCGC synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7697 c.396C>A synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCTC synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7721 c.420G>A synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7725 c.424C>T synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGT synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8135 c.834C>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.46 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8452 p.Ala384Val missense_variant 0.78 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8528 c.1227G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8708 c.1407G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 8762 c.1461G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.49 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.53 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.55 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.52 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCTG synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>A synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9153 p.Thr618Glu missense_variant 0.53 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9260 c.1959G>C synonymous_variant 0.47 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9267 p.Asn656Gly missense_variant 0.53 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 c.2007C>T synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9312 c.2011C>T synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9317 c.2016G>T synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
Rv0010c 13175 c.384T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 490803 c.21T>A synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 490812 c.30A>G synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fgd1 490815 c.33G>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fgd1 490827 c.45C>T synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fgd1 490848 c.66A>G synonymous_variant 0.44 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 490868 p.Ala29Gly missense_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 490887 c.105G>A synonymous_variant 0.59 pretomanid
delamanid
clofazimine
fgd1 490890 c.108C>G synonymous_variant 0.59 pretomanid
delamanid
clofazimine
fgd1 490896 c.114C>T synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fgd1 490905 c.123T>C synonymous_variant 0.61 pretomanid
delamanid
clofazimine
fgd1 490911 c.129T>G synonymous_variant 0.61 pretomanid
delamanid
clofazimine
fgd1 490917 c.135C>G synonymous_variant 0.61 pretomanid
delamanid
clofazimine
fgd1 490921 p.Gln47Glu missense_variant 0.61 pretomanid
delamanid
clofazimine
fgd1 490929 c.147C>G synonymous_variant 0.61 pretomanid
delamanid
clofazimine
fgd1 490932 c.150T>C synonymous_variant 0.61 pretomanid
delamanid
clofazimine
fgd1 490935 c.153C>G synonymous_variant 0.63 pretomanid
delamanid
clofazimine
fgd1 490948 p.Ser56Ala missense_variant 0.66 pretomanid
delamanid
clofazimine
fgd1 490962 c.180T>G synonymous_variant 0.64 pretomanid
delamanid
clofazimine
fgd1 490974 c.192T>C synonymous_variant 0.56 pretomanid
delamanid
clofazimine
fgd1 490977 c.195C>G synonymous_variant 0.58 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fgd1 490980 p.Asn66Lys missense_variant 0.58 pretomanid
delamanid
clofazimine
fgd1 490984 p.Leu68Ile missense_variant 0.58 pretomanid
delamanid
clofazimine
fgd1 490987 p.Leu69Thr missense_variant 0.58 pretomanid
delamanid
clofazimine
fgd1 490998 c.216T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491001 c.219G>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491007 c.225G>C synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fgd1 491013 c.231C>G synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fgd1 491043 c.261T>G synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fgd1 491049 c.267T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491063 p.Gly94Ala missense_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491077 p.Asn99Asp missense_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 491082 c.300T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491083 p.Val101Ile missense_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491091 c.309T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491094 c.312C>G synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491097 c.315G>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491100 c.318C>T synonymous_variant 0.43 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491106 c.324T>C synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fgd1 491121 c.339A>G synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 491130 c.348C>G synonymous_variant 0.47 pretomanid
delamanid
clofazimine
fgd1 491601 c.819T>C synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491616 c.834A>G synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fgd1 491620 p.Ile280Val missense_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 491643 c.861G>A synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491646 c.864G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491649 c.867C>T synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491658 c.876A>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491661 c.879C>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491673 c.891A>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491676 c.894T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491679 c.897A>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491687 p.Thr302Lys missense_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491697 c.915G>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fgd1 491709 c.927A>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491712 c.930T>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fgd1 491718 c.936A>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491721 c.939A>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491724 c.942A>T synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491727 c.945T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
fgd1 491748 p.Glu322Asp missense_variant 0.29 pretomanid
delamanid
clofazimine
mshA 575623 c.276C>G synonymous_variant 0.41 isoniazid
ethionamide
mshA 575629 c.282A>G synonymous_variant 0.36 isoniazid
ethionamide
mshA 575632 c.285G>C synonymous_variant 0.36 isoniazid
ethionamide
mshA 575635 c.288A>C synonymous_variant 0.36 isoniazid Not assoc w R - Interim
ethionamide
mshA 575638 c.291T>C synonymous_variant 0.36 isoniazid
ethionamide
mshA 575641 c.294A>G synonymous_variant 0.36 isoniazid
ethionamide
mshA 575647 c.300G>C synonymous_variant 0.36 isoniazid
ethionamide
mshA 575649 p.Val101Ala missense_variant 0.36 isoniazid
ethionamide
mshA 575659 c.312A>G synonymous_variant 0.41 isoniazid
ethionamide
mshA 575662 c.315C>G synonymous_variant 0.41 isoniazid
ethionamide
mshA 575665 c.318G>A synonymous_variant 0.43 isoniazid
ethionamide
mshA 575674 c.327G>C synonymous_variant 0.46 isoniazid
ethionamide
mshA 575695 c.348C>G synonymous_variant 0.44 isoniazid Not assoc w R - Interim
ethionamide
mshA 575701 c.354G>A synonymous_variant 0.44 isoniazid
ethionamide
mshA 575704 c.357T>G synonymous_variant 0.42 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.42 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.47 isoniazid
ethionamide
mshA 575719 c.372C>T synonymous_variant 0.44 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.52 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.52 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.5 isoniazid
ethionamide
mshA 575752 c.405G>C synonymous_variant 0.5 isoniazid
ethionamide
mshA 575755 c.408G>A synonymous_variant 0.46 isoniazid
ethionamide
mshA 575756 c.409C>T synonymous_variant 0.46 isoniazid
ethionamide
mshA 575770 c.423G>A synonymous_variant 0.52 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.52 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.53 isoniazid
ethionamide
mshA 575782 c.435G>C synonymous_variant 0.53 isoniazid
ethionamide
mshA 575809 c.462C>T synonymous_variant 0.52 isoniazid
ethionamide
mshA 575812 c.465C>T synonymous_variant 0.52 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.46 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.46 isoniazid
ethionamide
mshA 575830 c.483C>G synonymous_variant 0.47 isoniazid
ethionamide
mshA 575833 c.486C>G synonymous_variant 0.47 isoniazid
ethionamide
mshA 575845 c.498C>T synonymous_variant 0.48 isoniazid Not assoc w R - Interim
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.45 isoniazid
ethionamide
mshA 575887 c.540G>C synonymous_variant 0.45 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.45 isoniazid
ethionamide
mshA 575896 c.549G>C synonymous_variant 0.47 isoniazid
ethionamide
mshA 575908 c.561A>G synonymous_variant 0.5 isoniazid
ethionamide
mshA 575917 p.Asp190Glu missense_variant 0.5 isoniazid
ethionamide
mshA 575920 c.573C>G synonymous_variant 0.45 isoniazid
ethionamide
mshA 575924 p.Gly193Ser missense_variant 0.45 isoniazid
ethionamide
mshA 575944 c.597T>C synonymous_variant 0.45 isoniazid
ethionamide
mshA 575950 c.603C>G synonymous_variant 0.48 isoniazid
ethionamide
ccsA 620295 c.405G>T synonymous_variant 0.53 kanamycin
capreomycin
amikacin
ccsA 620310 c.420C>T synonymous_variant 0.53 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.47 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620346 c.456C>G synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.37 kanamycin
capreomycin
amikacin
Rv0565c 656448 p.Ile341Val missense_variant 0.59 ethionamide
Rv0565c 656454 c.1017G>C synonymous_variant 0.56 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.56 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.56 ethionamide
Rv0565c 656475 c.996A>G synonymous_variant 0.56 ethionamide
Rv0565c 656484 c.987T>C synonymous_variant 0.59 ethionamide
Rv0565c 656487 c.984T>C synonymous_variant 0.59 ethionamide Not assoc w R - Interim
Rv0565c 656493 c.978C>G synonymous_variant 0.67 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.42 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.43 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.48 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.55 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.53 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.43 isoniazid
hadA 731687 c.-243_-242insCACAGATCTTTT upstream_gene_variant 0.39 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.38 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.39 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.38 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.36 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.36 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.33 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.33 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.32 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.3 isoniazid
hadA 732253 c.324T>C synonymous_variant 0.27 isoniazid
hadA 732259 c.330T>C synonymous_variant 0.29 isoniazid
hadA 732268 c.339T>G synonymous_variant 0.29 isoniazid
hadA 732270 p.Glu114Val missense_variant 0.29 isoniazid
hadA 732272 p.Ala115Ser missense_variant 0.29 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.36 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.36 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.38 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.41 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.42 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.42 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.42 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.48 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.48 isoniazid
nusG 734116 c.-138T>C upstream_gene_variant 0.94 rifampicin Not assoc w R
nusG 734532 c.279A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.25 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.25 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.29 rifampicin
mmaA3 737899 p.Val84Ala missense_variant 1.0 isoniazid
rpoB 760091 c.285G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.5 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.67 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.62 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.51 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.38 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.32 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.31 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.31 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.32 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.29 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.25 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.43 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.44 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.58 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.53 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.52 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.48 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.45 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.5 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.33 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.33 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.33 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.38 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.38 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.38 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.35 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.35 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.41 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.41 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.41 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.56 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.67 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.86 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.74 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.65 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.65 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.56 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.56 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.52 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.5 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.44 rifampicin
rpoB 761373 p.Val523His missense_variant 0.39 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.47 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.47 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.5 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.5 rifampicin
rpoB 761439 p.Asp545Lys missense_variant 0.5 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.5 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.5 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.46 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.46 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.43 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.44 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.44 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.42 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.42 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.5 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.52 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.57 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.57 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.61 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.61 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.61 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.59 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.56 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.6 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.62 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.68 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.67 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.67 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.64 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.62 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.62 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.68 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.7 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.65 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.52 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.5 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.48 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.48 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.48 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.44 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.31 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.26 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.26 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.26 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.26 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.3 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.26 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.21 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.31 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.33 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.32 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.32 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.37 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.38 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.41 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.35 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.35 rifampicin Uncertain significance
rpoC 762521 c.-849C>T upstream_gene_variant 0.37 rifampicin
rpoB 762810 p.Ala1002Ser missense_variant 0.58 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.58 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762926 c.3120C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.41 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.5 rifampicin
rpoC 763025 c.-345C>T upstream_gene_variant 0.55 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.45 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.59 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.59 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.43 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.39 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.39 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.39 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.43 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.48 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.48 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763284 c.-86C>T upstream_gene_variant 0.38 rifampicin
rpoC 763351 c.-19T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoC 763352 c.-18T>A upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoC 763402 c.33C>G synonymous_variant 0.6 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.62 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.62 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.56 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>C synonymous_variant 0.39 rifampicin Not assoc w R
rpoC 763546 c.177A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.54 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.66 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.63 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.58 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.6 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.55 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.58 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.46 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.44 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.45 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.43 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.43 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.43 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.42 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.58 rifampicin Not assoc w R
rpoC 763886 p.Arg173Ser missense_variant 0.6 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.4 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.4 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.3 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.32 rifampicin
rpoC 763942 c.573C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763948 c.579G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763949 c.580C>A synonymous_variant 0.35 rifampicin
rpoC 763954 c.585C>G synonymous_variant 0.35 rifampicin
rpoC 763963 c.594C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.4 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.4 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.4 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.43 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.44 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.41 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.41 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.41 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.41 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.4 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.5 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.53 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.55 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.52 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.56 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.5 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.5 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.5 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.44 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.56 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.52 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.58 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.56 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.56 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.5 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.65 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.64 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.61 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.53 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.56 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.56 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.57 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.48 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.52 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.5 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.5 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.47 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.48 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.45 rifampicin
rpoC 765292 c.1923G>C synonymous_variant 0.43 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.43 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.43 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.48 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.48 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.5 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.48 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.65 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.62 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.58 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.56 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.52 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.52 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.53 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.53 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.49 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.32 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.33 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.37 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.4 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.37 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.37 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.37 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.35 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.44 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.48 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.5 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.45 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.44 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.46 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.46 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.35 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.37 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.45 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.49 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.51 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.46 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.46 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.46 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.45 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.45 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.45 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.42 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.42 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.52 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.59 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.63 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.64 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.64 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.68 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.68 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.68 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.63 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.69 rifampicin
rpoC 766549 c.3180G>T synonymous_variant 0.67 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.62 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.68 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.67 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.71 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.71 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.62 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.58 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.62 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.62 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.65 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.65 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.64 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.64 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.52 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.76 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.73 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.73 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.73 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.79 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.78 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.69 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.69 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.74 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.65 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.68 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.5 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.39 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.42 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.44 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.44 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.44 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.44 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.44 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.44 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.44 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.43 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.43 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.44 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.38 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.39 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.42 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.41 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.37 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.38 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.38 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.36 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.38 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.41 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.41 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.41 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.42 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
rplC 800612 c.-197A>G upstream_gene_variant 0.28 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.29 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.32 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.44 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.44 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.62 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.65 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.65 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.65 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.65 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.53 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.47 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.4 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.41 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.41 linezolid
rplC 800814 c.6A>G synonymous_variant 0.46 linezolid
rplC 800817 c.9A>T synonymous_variant 0.46 linezolid
rplC 800844 c.36T>C synonymous_variant 0.48 linezolid
rplC 800865 c.57A>G synonymous_variant 0.38 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.38 linezolid
rplC 800874 c.66A>G synonymous_variant 0.38 linezolid
rplC 800875 p.Val23Ile missense_variant 0.38 linezolid
rplC 800880 c.72A>G synonymous_variant 0.38 linezolid
rplC 800889 c.81C>G synonymous_variant 0.38 linezolid
rplC 800892 c.84G>C synonymous_variant 0.36 linezolid
rplC 800907 c.99C>G synonymous_variant 0.32 linezolid
rplC 800916 c.108A>G synonymous_variant 0.32 linezolid
rplC 800934 c.126C>G synonymous_variant 0.32 linezolid
rplC 800937 c.129A>G synonymous_variant 0.32 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.32 linezolid
rplC 800946 c.138T>C synonymous_variant 0.29 linezolid
rplC 800949 c.141T>C synonymous_variant 0.29 linezolid
rplC 800967 c.159C>G synonymous_variant 0.36 linezolid
rplC 800970 c.162T>C synonymous_variant 0.36 linezolid Not assoc w R - Interim
rplC 800982 c.174C>T synonymous_variant 0.36 linezolid
rplC 800985 c.177A>G synonymous_variant 0.36 linezolid
rplC 801004 p.Leu66Val missense_variant 0.3 linezolid
rplC 801009 c.201A>C synonymous_variant 0.3 linezolid
rplC 801039 c.231A>G synonymous_variant 0.5 linezolid
rplC 801045 c.237A>G synonymous_variant 0.5 linezolid
rplC 801047 p.Tyr80Phe missense_variant 0.5 linezolid
rplC 801049 c.241C>T synonymous_variant 0.5 linezolid
rplC 801054 c.246G>C synonymous_variant 0.56 linezolid
rplC 801070 p.Asp88Asn missense_variant 0.56 linezolid
rplC 801073 p.Ser89Pro missense_variant 0.56 linezolid
rplC 801078 c.270T>C synonymous_variant 0.56 linezolid
rplC 801081 c.273C>G synonymous_variant 0.56 linezolid Not assoc w R - Interim
rplC 801085 p.Thr93Ala missense_variant 0.56 linezolid Uncertain significance
rplC 801090 c.282G>A synonymous_variant 0.5 linezolid
rplC 801099 c.291T>C synonymous_variant 0.5 linezolid
rplC 801102 c.294G>C synonymous_variant 0.5 linezolid
rplC 801105 c.297A>G synonymous_variant 0.5 linezolid
rplC 801109 c.301T>C synonymous_variant 0.5 linezolid Not assoc w R - Interim
rplC 801114 c.306C>G synonymous_variant 0.5 linezolid
rplC 801117 c.309G>C synonymous_variant 0.5 linezolid
rplC 801127 p.Ala107Thr missense_variant 0.52 linezolid
rplC 801132 c.324T>C synonymous_variant 0.5 linezolid
rplC 801147 c.339T>C synonymous_variant 0.5 linezolid
rplC 801150 c.342G>C synonymous_variant 0.48 linezolid
rplC 801153 c.345G>C synonymous_variant 0.5 linezolid
rplC 801156 c.348T>A synonymous_variant 0.5 linezolid
rplC 801168 c.360C>G synonymous_variant 0.54 linezolid
rplC 801171 c.363A>G synonymous_variant 0.57 linezolid
rplC 801174 c.366T>C synonymous_variant 0.54 linezolid
rplC 801195 c.387G>C synonymous_variant 0.57 linezolid
rplC 801207 c.399C>T synonymous_variant 0.5 linezolid
rplC 801246 c.438C>T synonymous_variant 0.56 linezolid
rplC 801249 c.441T>C synonymous_variant 0.54 linezolid
rplC 801255 c.447C>T synonymous_variant 0.54 linezolid
rplC 801264 c.456C>T synonymous_variant 0.54 linezolid
rplC 801267 c.459A>T synonymous_variant 0.46 linezolid
rplC 801270 c.462T>C synonymous_variant 0.46 linezolid
rplC 801276 c.468G>C synonymous_variant 0.46 linezolid
rplC 801279 c.471G>C synonymous_variant 0.46 linezolid
rplC 801282 c.474G>C synonymous_variant 0.44 linezolid
rplC 801285 c.477G>C synonymous_variant 0.44 linezolid
rplC 801300 c.492C>G synonymous_variant 0.46 linezolid
rplC 801309 c.501C>G synonymous_variant 0.44 linezolid
rplC 801312 c.504G>C synonymous_variant 0.44 linezolid
rplC 801321 c.513C>T synonymous_variant 0.44 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.44 linezolid
rplC 801339 c.531T>C synonymous_variant 0.39 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.39 linezolid
rplC 801348 c.540T>G synonymous_variant 0.39 linezolid
rplC 801357 c.549T>C synonymous_variant 0.38 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.34 linezolid
rplC 801402 c.594T>C synonymous_variant 0.32 linezolid
rplC 801405 c.597T>C synonymous_variant 0.33 linezolid
rplC 801427 p.Met207Val missense_variant 0.33 linezolid
rplC 801438 c.630T>C synonymous_variant 0.37 linezolid
rplC 801442 p.Ile212Val missense_variant 0.37 linezolid
fbiC 1302692 c.-239C>G upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1303455 c.525C>G synonymous_variant 0.32 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303464 c.534A>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303470 c.540T>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303476 c.546G>C synonymous_variant 0.33 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303480 p.Gln184Glu missense_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1303489 c.559C>T synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303497 c.567G>A synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303501 c.571C>T synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1303509 c.579G>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1303512 c.582T>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1303521 c.591C>T synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1303530 c.600G>A synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1303534 p.Ser202Ala missense_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1303539 c.609G>C synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.63 pretomanid
delamanid
clofazimine
fbiC 1303590 c.660A>G synonymous_variant 0.65 pretomanid
delamanid
clofazimine
fbiC 1303602 c.672A>G synonymous_variant 0.65 pretomanid
delamanid
clofazimine
fbiC 1303605 c.675C>G synonymous_variant 0.65 pretomanid
delamanid
clofazimine
fbiC 1303608 c.678G>A synonymous_variant 0.65 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>T synonymous_variant 0.65 pretomanid
delamanid
clofazimine
fbiC 1303617 c.687C>G synonymous_variant 0.63 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.66 pretomanid
delamanid
clofazimine
fbiC 1303641 c.711C>T synonymous_variant 0.66 pretomanid
delamanid
clofazimine
fbiC 1303650 c.720G>C synonymous_variant 0.65 pretomanid
delamanid
clofazimine
fbiC 1303654 c.724C>T synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1303659 c.729T>C synonymous_variant 0.62 pretomanid
delamanid
clofazimine
fbiC 1303661 p.Val244Ala missense_variant 0.59 pretomanid
delamanid
clofazimine
fbiC 1303663 c.733C>T synonymous_variant 0.59 pretomanid
delamanid
clofazimine
fbiC 1303671 c.741C>T synonymous_variant 0.57 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1303674 c.744C>G synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1303681 c.751T>C synonymous_variant 0.61 pretomanid
delamanid
clofazimine
fbiC 1303686 c.756C>G synonymous_variant 0.61 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.46 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.51 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.51 pretomanid
delamanid
clofazimine
fbiC 1303797 c.867A>G synonymous_variant 0.49 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.56 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304671 p.Val581Thr missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Glu missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Asp missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.26 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304739 c.1809C>T synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.46 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.48 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.54 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.52 pretomanid
delamanid
clofazimine
sigE 1364862 c.450C>A synonymous_variant 0.26 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.26 pyrazinamide
sigE 1364868 c.456T>G synonymous_variant 0.26 pyrazinamide
Rv1258c 1406312 c.1029T>C synonymous_variant 1.0 streptomycin Not assoc w R
pyrazinamide Not assoc w R
isoniazid Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.79 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.56 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.58 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.6 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.69 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
inhA 1673574 c.-628C>G upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673580 c.-622T>G upstream_gene_variant 0.26 isoniazid Uncertain significance
ethionamide
inhA 1673589 c.-613A>G upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673591 c.-611C>T upstream_gene_variant 0.26 isoniazid Uncertain significance
ethionamide
inhA 1673595 c.-607A>C upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673596 c.-606A>G upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673602 c.-600C>T upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673607 c.-595T>C upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673615 c.-587_-586delAAinsTG upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673619 c.-583T>C upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673633 c.-569G>A upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1673637 c.-565C>G upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1673641 c.-561G>A upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1673657 c.-545C>A upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1673660 c.-542C>A upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1673664 c.-538A>C upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1673667 c.-535A>G upstream_gene_variant 0.32 isoniazid
ethionamide
inhA 1673679 c.-523T>C upstream_gene_variant 0.31 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1673685 c.-517C>T upstream_gene_variant 0.31 isoniazid
ethionamide
inhA 1673710 c.-492C>A upstream_gene_variant 0.38 isoniazid
ethionamide
inhA 1673716 c.-486_-485delGCinsAA upstream_gene_variant 0.36 isoniazid
ethionamide
inhA 1673733 c.-469G>C upstream_gene_variant 0.43 isoniazid
ethionamide
inhA 1673748 c.-454A>G upstream_gene_variant 0.38 isoniazid
ethionamide
inhA 1673749 c.-453_-452delAAinsCG upstream_gene_variant 0.38 isoniazid
ethionamide
inhA 1673758 c.-444A>G upstream_gene_variant 0.38 isoniazid
ethionamide
inhA 1673890 c.-312G>T upstream_gene_variant 0.71 isoniazid
ethionamide
inhA 1673901 c.-301A>G upstream_gene_variant 0.74 isoniazid
ethionamide
inhA 1673905 c.-297T>G upstream_gene_variant 0.78 isoniazid
ethionamide
inhA 1673916 c.-286A>C upstream_gene_variant 0.74 isoniazid
ethionamide
inhA 1673917 c.-285G>C upstream_gene_variant 0.74 isoniazid
ethionamide
inhA 1673922 c.-280T>C upstream_gene_variant 0.74 isoniazid
ethionamide
inhA 1673941 c.-261G>T upstream_gene_variant 0.71 isoniazid
ethionamide
inhA 1673955 c.-247G>C upstream_gene_variant 0.68 isoniazid
ethionamide
inhA 1673961 c.-241A>C upstream_gene_variant 0.68 isoniazid
ethionamide
inhA 1673985 c.-217C>G upstream_gene_variant 0.59 isoniazid
ethionamide
inhA 1674006 c.-196T>G upstream_gene_variant 0.39 isoniazid
ethionamide
inhA 1674015 c.-187C>T upstream_gene_variant 0.31 isoniazid Uncertain significance
ethionamide
inhA 1674018 c.-184G>C upstream_gene_variant 0.31 isoniazid
ethionamide
inhA 1674021 c.-181G>C upstream_gene_variant 0.31 isoniazid
ethionamide
inhA 1674024 c.-178T>C upstream_gene_variant 0.31 isoniazid
ethionamide
inhA 1674033 c.-169T>C upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1674037 c.-165_-164delCAinsGC upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1674042 c.-160G>T upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1674049 c.-153_-151delCAAinsGAC upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1674054 c.-148T>C upstream_gene_variant 0.28 isoniazid
ethionamide
inhA 1674060 c.-142A>G upstream_gene_variant 0.28 isoniazid
ethionamide
inhA 1674063 c.-139G>C upstream_gene_variant 0.28 isoniazid
ethionamide
inhA 1674079 c.-123C>G upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1674105 c.-97C>T upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1674114 c.-88T>A upstream_gene_variant 0.24 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1674123 c.-79T>C upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1674126 c.-76G>C upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1674132 c.-70T>C upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1674136 c.-66T>G upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1674141 c.-61T>C upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1674162 c.-40C>T upstream_gene_variant 0.68 isoniazid Not assoc w R
ethionamide Uncertain significance
inhA 1674177 c.-25C>T upstream_gene_variant 0.3 isoniazid Uncertain significance
ethionamide Uncertain significance
inhA 1674181 c.-21_-20insGATTTCAACGAC upstream_gene_variant 0.25 isoniazid
ethionamide
inhA 1674190 c.-12_-11delACinsGACTTT upstream_gene_variant 0.38 isoniazid
ethionamide
inhA 1674199 c.-3C>G upstream_gene_variant 0.38 isoniazid Uncertain significance
ethionamide
inhA 1674205 p.Thr2Ala missense_variant 0.33 isoniazid Uncertain significance
ethionamide
inhA 1674216 c.15G>C synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674231 c.30T>C synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674235 p.Val12Ile missense_variant 0.44 isoniazid Uncertain significance
ethionamide
inhA 1674238 c.37_39delAGCinsTCG synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674243 c.42A>G synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674279 c.78A>C synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674280 p.Arg27Lys missense_variant 0.41 isoniazid
ethionamide
inhA 1674284 p.Val28Ala missense_variant 0.44 isoniazid
ethionamide
inhA 1674292 c.92dupA frameshift_variant 0.35 isoniazid
ethionamide
inhA 1674296 p.Gln32Pro missense_variant 0.33 isoniazid
ethionamide
inhA 1674299 c.99delC frameshift_variant 0.33 isoniazid
ethionamide
inhA 1674303 c.102C>G synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674307 c.106C>T synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674315 c.114C>G synonymous_variant 0.36 isoniazid
ethionamide
inhA 1674321 c.120G>T synonymous_variant 0.36 isoniazid
ethionamide
inhA 1674324 c.123C>T synonymous_variant 0.36 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674331 c.130C>T synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674336 c.135G>C synonymous_variant 0.43 isoniazid
ethionamide
inhA 1674352 p.Thr51Ala missense_variant 0.43 isoniazid
ethionamide Uncertain significance
rpsA 1833554 p.Thr5Ala missense_variant 0.3 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.3 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.55 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.62 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.62 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.64 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.6 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.62 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.62 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.63 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.63 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.64 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.64 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.65 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.64 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.61 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.58 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.59 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.57 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.45 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.47 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.47 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.59 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.42 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.46 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.46 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.42 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.44 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.53 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.45 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.45 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.54 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.7 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.7 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.68 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.68 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.7 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.6 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.65 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.6 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.6 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.58 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.56 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.53 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.36 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.36 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.36 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.36 linezolid
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
ndh 2101804 c.1239T>G synonymous_variant 0.33 isoniazid
delamanid
ethionamide
ndh 2101808 p.Thr412Ser missense_variant 0.33 isoniazid
delamanid
ethionamide
ndh 2101830 p.Ile405Val missense_variant 0.44 isoniazid
delamanid
ethionamide
ndh 2101837 p.Ala402Val missense_variant 0.43 isoniazid Uncertain significance
delamanid
ethionamide Uncertain significance
ndh 2101858 p.LeuIle394PheAla missense_variant 0.41 isoniazid
delamanid
ethionamide
ndh 2101872 p.Ile391Phe missense_variant 0.39 isoniazid
delamanid
ethionamide
ndh 2101873 p.Phe390Leu missense_variant 0.39 isoniazid
delamanid
ethionamide
ndh 2101885 c.1158G>A synonymous_variant 0.39 isoniazid
delamanid
ethionamide
ndh 2101888 c.1155T>C synonymous_variant 0.39 isoniazid
delamanid
ethionamide
ndh 2101894 c.1149T>G synonymous_variant 0.39 isoniazid
delamanid
ethionamide
ndh 2101912 c.1131G>C synonymous_variant 0.41 isoniazid
delamanid
ethionamide
ndh 2101920 c.1123A>C synonymous_variant 0.43 isoniazid
delamanid
ethionamide
ndh 2101924 c.1119T>G synonymous_variant 0.4 isoniazid
delamanid
ethionamide
ndh 2101939 c.1104A>G synonymous_variant 0.43 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223444 c.-280G>A upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
pncA 2289296 c.-56delG upstream_gene_variant 1.0 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.5 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.42 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.39 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.38 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.43 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.46 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.43 isoniazid
kasA 2519048 p.Gly312Arg missense_variant 0.78 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.25 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.35 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0 isoniazid
Rv2477c 2782669 c.1374A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782680 c.1363T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782684 c.1359T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782695 c.1348A>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782705 c.1338G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782711 c.1332C>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782714 c.1329A>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782720 c.1323T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782729 c.1314A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782732 c.1311A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782741 c.1302G>A synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782750 c.1293T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782777 c.1266A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.39 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.64 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.6 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.55 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.5 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.47 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.56 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.58 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.59 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.61 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.61 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.63 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.63 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.72 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.72 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.72 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.71 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.74 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.77 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.77 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.8 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.82 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.82 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.82 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.84 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.81 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.78 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.78 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.78 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783179 c.864G>C synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.76 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783209 c.834G>A synonymous_variant 0.73 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.71 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.71 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.7 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.7 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.69 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.65 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.61 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.61 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.61 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.58 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.57 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.58 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.54 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.52 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.48 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.44 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3065223 c.969T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065229 c.963G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065232 c.960T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065241 c.951A>G synonymous_variant 0.53 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066360 c.-169T>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066369 c.-180_-178delAGCinsGCG upstream_gene_variant 0.41 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066380 c.-189A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066396 c.-207_-205delGCGinsACC upstream_gene_variant 0.41 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066399 c.-210_-208delATTinsTCC upstream_gene_variant 0.41 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066432 c.-241T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066435 c.-246_-244delGGTinsAAC upstream_gene_variant 0.5 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066452 c.-261T>A upstream_gene_variant 0.53 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066453 c.-262G>A upstream_gene_variant 0.5 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066456 c.-265A>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066462 c.-271G>A upstream_gene_variant 0.44 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066465 c.-276_-274delGGGinsAAT upstream_gene_variant 0.47 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066471 c.-280A>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066476 c.-285C>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066482 c.-291G>T upstream_gene_variant 0.55 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066483 c.-292T>C upstream_gene_variant 0.55 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.52 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.55 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.55 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066561 c.-370A>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.45 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066582 c.-392_-391delCCinsGG upstream_gene_variant 0.41 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066617 c.-426G>A upstream_gene_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066618 c.-427A>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066633 c.-442T>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066638 c.-447T>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066642 c.-453_-451delTTGinsCTC upstream_gene_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066645 c.-454G>A upstream_gene_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066654 c.-463G>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066657 c.-466C>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066734 c.-543G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066736 c.-545C>T upstream_gene_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066780 c.-589C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066810 c.-619G>A upstream_gene_variant 0.36 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067391 c.555G>C synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.48 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.38 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.34 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.37 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.37 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.39 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.39 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.39 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.44 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067691 p.Ile85Leu missense_variant 0.57 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067736 p.Phe70Leu missense_variant 0.48 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.54 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.54 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.41 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
whiB7 3568488 c.191delG frameshift_variant 1.0 kanamycin Uncertain significance
amikacin Uncertain significance
streptomycin Uncertain significance
lpqB 3624077 c.834G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624082 c.829A>C synonymous_variant 0.35 rifampicin
bedaquiline
lpqB 3624086 c.825C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625687 c.-777G>C upstream_gene_variant 0.33 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625735 c.-825C>T upstream_gene_variant 0.35 rifampicin
bedaquiline
lpqB 3625749 c.-839C>T upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.33 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.39 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625900 c.-990G>C upstream_gene_variant 0.35 rifampicin
bedaquiline
lpqB 3625903 c.-993G>C upstream_gene_variant 0.28 rifampicin
bedaquiline
lpqB 3625909 c.-999T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3625923 c.691C>T synonymous_variant 0.3 rifampicin
bedaquiline
mtrB 3625927 c.687T>C synonymous_variant 0.3 rifampicin
bedaquiline
mtrB 3625930 c.684C>G synonymous_variant 0.32 rifampicin
bedaquiline
mtrB 3625936 c.678C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625942 c.672C>G synonymous_variant 0.3 rifampicin
bedaquiline
mtrB 3625945 c.669A>G synonymous_variant 0.32 rifampicin
bedaquiline
mtrB 3625951 c.663A>T synonymous_variant 0.29 rifampicin
bedaquiline
mtrB 3625955 p.Leu220Ala missense_variant 0.32 rifampicin
bedaquiline
mtrB 3625972 c.642G>C synonymous_variant 0.3 rifampicin
bedaquiline
mtrB 3625978 c.636T>C synonymous_variant 0.3 rifampicin
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3626912 c.-299T>G upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.57 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.57 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.58 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.59 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.59 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.48 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.5 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.54 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.51 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.53 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.48 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.52 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.52 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.52 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.52 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTA upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.3 rifampicin
bedaquiline
fbiA 3640557 c.15T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
rpoA 3877553 p.Glu319Gln missense_variant 0.26 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.27 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.32 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.36 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.41 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.36 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.51 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.52 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.52 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.5 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.45 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.47 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.47 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.47 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.45 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.45 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.49 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.47 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.47 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.47 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.46 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.46 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.46 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.43 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.43 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.43 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.46 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878094 c.414C>G synonymous_variant 0.45 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.45 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.44 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.41 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.42 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.38 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.38 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.39 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.38 rifampicin
rpoA 3878181 c.327C>T synonymous_variant 0.39 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.38 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.38 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.39 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.43 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.39 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.42 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.41 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.41 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.41 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.39 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.38 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.38 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.37 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.34 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.34 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.27 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.29 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.33 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.33 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.33 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.53 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.59 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.59 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.59 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.59 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.59 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.61 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.67 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.67 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.67 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.72 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.81 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.76 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.76 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.76 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.75 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.73 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.67 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.68 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.66 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.67 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.65 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.61 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.55 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.53 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.55 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.55 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.55 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.57 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.56 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.5 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.53 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.51 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.37 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.42 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.57 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.65 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.65 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.62 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.71 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.71 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.71 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.71 rifampicin
clpC1 4038239 c.2466T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038255 p.Val817Lys missense_variant 0.43 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.4 pyrazinamide
clpC1 4038272 p.Gly811Ser missense_variant 0.4 pyrazinamide
clpC1 4038275 c.2430A>G synonymous_variant 0.4 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.43 pyrazinamide
clpC1 4038308 p.Val799Ile missense_variant 0.39 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.56 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.65 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.67 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.61 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.64 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.67 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.61 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.61 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.58 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.64 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.64 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.53 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.53 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.55 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.55 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.57 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.61 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.64 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.58 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.56 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.6 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.56 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.56 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.42 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.44 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.44 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.41 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.44 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.44 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.49 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.48 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.52 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.57 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.55 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.6 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.58 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.52 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.64 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.59 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.56 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.6 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.6 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.67 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.8 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.77 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.83 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.77 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.56 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.47 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.45 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.39 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.41 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.44 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.63 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.64 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.62 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.62 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.63 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.65 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.57 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.69 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.69 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.75 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.66 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.66 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.51 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.56 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.52 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.44 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.44 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.29 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.38 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.58 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.59 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.6 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.59 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.62 pyrazinamide
clpC1 4040210 c.495G>C synonymous_variant 0.62 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.67 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.71 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.71 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.71 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.71 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.73 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.71 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.69 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.69 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.68 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.68 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.65 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.67 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.65 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.72 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.73 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.68 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.69 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.68 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.63 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.5 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.48 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.43 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.4 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.44 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.45 pyrazinamide
clpC1 4040501 c.204C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040517 p.Val63Ala missense_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.42 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.45 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.36 pyrazinamide
clpC1 4040567 c.138C>G synonymous_variant 0.36 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.36 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040582 c.123G>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.35 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.35 pyrazinamide
clpC1 4040596 c.109C>T synonymous_variant 0.36 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.36 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCTG synonymous_variant 0.36 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.38 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.38 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.35 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.36 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.35 pyrazinamide
panD 4044746 c.-467_-465delGTGinsATC upstream_gene_variant 0.33 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.36 pyrazinamide
panD 4044758 c.-477C>T upstream_gene_variant 0.33 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.33 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.36 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.33 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.33 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.35 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.26 pyrazinamide
panD 4044848 c.-567T>G upstream_gene_variant 0.23 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.28 pyrazinamide
panD 4044860 c.-579C>G upstream_gene_variant 0.31 pyrazinamide
panD 4044872 c.-591C>G upstream_gene_variant 0.35 pyrazinamide
panD 4044890 c.-609G>C upstream_gene_variant 0.26 pyrazinamide
panD 4044895 c.-614A>G upstream_gene_variant 0.24 pyrazinamide
panD 4044896 c.-615T>G upstream_gene_variant 0.24 pyrazinamide
panD 4044902 c.-623_-621delACGinsGCC upstream_gene_variant 0.24 pyrazinamide
panD 4044908 c.-628_-627delCTinsTC upstream_gene_variant 0.24 pyrazinamide
panD 4044917 c.-636G>C upstream_gene_variant 0.24 pyrazinamide
panD 4044920 c.-639C>T upstream_gene_variant 0.24 pyrazinamide
panD 4044926 c.-645C>A upstream_gene_variant 0.25 pyrazinamide
panD 4044929 c.-648G>C upstream_gene_variant 0.25 pyrazinamide
panD 4044935 c.-656_-654delCAAinsTTG upstream_gene_variant 0.25 pyrazinamide
panD 4044941 c.-660G>C upstream_gene_variant 0.26 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.31 pyrazinamide
panD 4044959 c.-678C>G upstream_gene_variant 0.31 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.41 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.41 pyrazinamide
panD 4044986 c.-705C>G upstream_gene_variant 0.41 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.45 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.47 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.47 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.45 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.45 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.45 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.45 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.44 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.36 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.36 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.33 pyrazinamide
panD 4045088 c.-807T>C upstream_gene_variant 0.33 pyrazinamide
panD 4045094 c.-813T>C upstream_gene_variant 0.23 pyrazinamide
panD 4045097 c.-816T>C upstream_gene_variant 0.26 pyrazinamide
panD 4045105 c.-824T>C upstream_gene_variant 0.26 pyrazinamide
panD 4045112 c.-831A>G upstream_gene_variant 0.23 pyrazinamide
panD 4045115 c.-834G>C upstream_gene_variant 0.23 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4138718 c.1038T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138721 c.1035G>A synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.36 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138730 c.1026C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138763 c.993G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139408 c.348T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139432 c.324C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139537 c.219G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139541 p.Ile72Thr missense_variant 0.38 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139545 c.211T>C synonymous_variant 0.38 levofloxacin
moxifloxacin Not assoc w R - Interim
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139552 p.Ala68Ser missense_variant 0.38 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139561 c.195G>A synonymous_variant 0.47 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139581 p.Asn59Asp missense_variant 0.44 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139597 c.159C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139601 p.Arg52Gln missense_variant 0.35 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139611 p.Ile49Val missense_variant 0.4 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139615 c.141G>A synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
embC 4240645 c.783G>C synonymous_variant 0.33 ethambutol
embC 4240669 c.807G>C synonymous_variant 0.35 ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240677 p.Gly272Ala missense_variant 0.37 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.37 ethambutol
embC 4240693 c.831T>G synonymous_variant 0.37 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.62 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.63 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.6 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.69 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.71 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.71 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.7 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.7 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.7 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.7 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.7 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.7 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.7 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTTG synonymous_variant 0.7 ethambutol
embC 4240903 c.1041C>G synonymous_variant 0.7 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.73 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.73 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.77 ethambutol
embC 4240945 c.1083T>G synonymous_variant 0.77 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.71 ethambutol
embC 4240960 c.1098G>C synonymous_variant 0.71 ethambutol
embC 4240966 c.1104G>C synonymous_variant 0.67 ethambutol
embC 4240969 c.1107C>T synonymous_variant 0.64 ethambutol Not assoc w R - Interim
embC 4240972 c.1110C>G synonymous_variant 0.64 ethambutol
embC 4240979 p.Thr373Gln missense_variant 0.6 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.56 ethambutol
embC 4240987 c.1125G>C synonymous_variant 0.56 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.56 ethambutol
embC 4240996 c.1134G>C synonymous_variant 0.56 ethambutol
embC 4241002 c.1140G>C synonymous_variant 0.56 ethambutol
embC 4241013 p.Met384Thr missense_variant 0.56 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.59 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.61 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.61 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.61 ethambutol
embC 4241042 p.Asn394Asp missense_variant 0.35 ethambutol Not assoc w R
embC 4241047 c.1185C>G synonymous_variant 0.62 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.62 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.62 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.64 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.6 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.62 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.6 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.56 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.46 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.46 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.46 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.46 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.46 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.48 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.48 ethambutol Not assoc w R - Interim
embC 4241218 c.1356G>C synonymous_variant 0.42 ethambutol
embC 4241230 c.1368A>G synonymous_variant 0.34 ethambutol
embC 4241233 c.1371G>C synonymous_variant 0.37 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.41 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.41 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.46 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.46 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.46 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.46 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.46 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.46 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.46 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.44 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>A synonymous_variant 0.52 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.52 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.52 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.48 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.48 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.48 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.55 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.55 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.53 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.56 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.53 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.56 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.41 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.41 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.37 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.82 ethambutol Not assoc w R
embC 4242791 p.Ala977Ser missense_variant 0.55 ethambutol
embA 4242796 c.-437G>C upstream_gene_variant 0.6 ethambutol
embA 4242799 c.-434T>C upstream_gene_variant 0.6 ethambutol
embA 4242820 c.-413G>C upstream_gene_variant 0.5 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.5 ethambutol
embA 4242832 c.-401A>C upstream_gene_variant 0.46 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.38 ethambutol
embA 4243580 c.348G>A synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244420 c.1188G>C synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244534 c.1302T>C synonymous_variant 0.32 ethambutol
embA 4244537 c.1305T>G synonymous_variant 0.32 ethambutol
embA 4244543 c.1311C>G synonymous_variant 0.35 ethambutol
embA 4244547 p.Ile439Val missense_variant 0.35 ethambutol
embA 4244552 c.1320C>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embA 4244557 p.Arg442Thr missense_variant 0.39 ethambutol
embA 4244567 c.1335C>T synonymous_variant 0.37 ethambutol
embA 4244582 c.1350T>C synonymous_variant 0.36 ethambutol
embA 4244611 p.Ala460Gly missense_variant 0.33 ethambutol
embA 4244616 p.Ala462Ser missense_variant 0.33 ethambutol
embA 4244619 c.1387_1389delTTGinsCTC synonymous_variant 0.35 ethambutol
embA 4244625 p.Leu465Val missense_variant 0.35 ethambutol
embA 4244631 p.Thr467Leu missense_variant 0.38 ethambutol
embA 4244645 c.1413T>C synonymous_variant 0.39 ethambutol
embA 4244648 c.1416G>C synonymous_variant 0.39 ethambutol
embA 4244649 p.Asp473Ser missense_variant 0.39 ethambutol
embA 4245969 p.Pro913Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4247464 c.951C>G synonymous_variant 0.25 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.25 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.25 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.25 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.29 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.37 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.41 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.41 ethambutol
embB 4247578 c.1065G>A synonymous_variant 0.59 ethambutol Not assoc w R
embB 4247579 p.Ala356Phe missense_variant 0.41 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.41 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.44 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.44 ethambutol
embB 4247632 c.1119C>G synonymous_variant 0.47 ethambutol
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247692 c.1179C>G synonymous_variant 0.5 ethambutol
embB 4247716 c.1203C>T synonymous_variant 0.39 ethambutol
embB 4247722 c.1209G>T synonymous_variant 0.39 ethambutol
embB 4247725 c.1212G>C synonymous_variant 0.39 ethambutol
embB 4247729 p.Gly406Pro missense_variant 0.39 ethambutol
embB 4247746 c.1233C>T synonymous_variant 0.5 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.56 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.58 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.55 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.58 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.55 ethambutol Uncertain significance
embB 4247839 c.1326G>C synonymous_variant 0.48 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.46 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.46 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.44 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.46 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.46 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.48 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.48 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.46 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.46 ethambutol
embB 4247932 c.1419C>G synonymous_variant 0.5 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.48 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.48 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.5 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.46 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.42 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.36 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.36 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.41 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.55 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.55 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.55 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.55 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.5 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.64 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.53 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.54 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.54 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.53 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.51 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.51 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.49 ethambutol Not assoc w R - Interim
embB 4248199 c.1686A>G synonymous_variant 0.41 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.41 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.38 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.38 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.37 ethambutol
embB 4249369 c.2856T>C synonymous_variant 0.29 ethambutol
embB 4249375 c.2862G>C synonymous_variant 0.32 ethambutol
embB 4249381 c.2868A>G synonymous_variant 0.32 ethambutol
embB 4249384 c.2871G>T synonymous_variant 0.32 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.45 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.5 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.5 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.53 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.5 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.5 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.5 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.53 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.53 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.56 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.53 ethambutol
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338361 p.Arg54Gln missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 1.0 streptomycin Not assoc w R