TB-Profiler result

Run: ERR4814536
Summary

Run ID: ERR4814536

Sample name:

Date: 2024-04-15T04:36:03.849147

Number of reads: 3755701

Percentage reads mapped: 60.42

Median coverage: 70.0

Strain: M.canetti;lineage2.1;lineage3

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.89
lineage2.1 East-Asian (non-Beijing) None 0.06
M.canetti M.canetti None 0.08
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Ser450Leu Assoc w R
rpoC p.Leu527Val Uncertain significance Mutation from literature
isoniazid katG p.Ile335Thr Mutation from literature
p.Ser315Thr Assoc w R High-level resistance
c.496_498delGTTinsAC Assoc w R High-level resistance
ethambutol embA c.-12C>T Uncertain significance Mutation from literature
embB p.His312Arg Mutation from literature
p.Ala388Gly Mutation from literature
p.Asn399Asp Mutation from literature
pyrazinamide
streptomycin rpsL p.Lys43Arg Assoc w R
rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.838_840delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.550_552delCAAinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.604_606delTCGinsGC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1948_1950delCGCinsAG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.39 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491620 c.838_840delATCinsGG frameshift_variant&missense_variant 0.27 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.37 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761155 p.Ser450Leu missense_variant 0.55 rifampicin Assoc w R
rpoC 764948 p.Leu527Val missense_variant 0.68 rifampicin Uncertain significance Mutation from literature
rpsL 781687 p.Lys43Arg missense_variant 0.66 streptomycin Assoc w R
fbiC 1303480 c.550_552delCAAinsGG frameshift_variant&missense_variant 0.28 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303534 c.604_606delTCGinsGC frameshift_variant&missense_variant 0.38 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.35 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.56 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304878 c.1948_1950delCGCinsAG frameshift_variant&missense_variant 0.28 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.39 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance Mutation from literature
katG 2155108 p.Ile335Thr missense_variant 0.24 isoniazid Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 0.99 isoniazid Assoc w R High-level resistance
katG 2155614 c.496_498delGTTinsAC frameshift_variant&missense_variant 0.21 isoniazid Assoc w R High-level resistance
embA 4243221 c.-12C>T upstream_gene_variant 1.0 ethambutol Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.42 ethambutol Mutation from literature
embB 4247676 p.Ala388Gly missense_variant 0.21 ethambutol Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.28 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 180 c.180T>C synonymous_variant 0.93 isoniazid Not assoc w R - Interim
dnaA 571 c.571T>C synonymous_variant 0.34 isoniazid
dnaA 576 c.576G>C synonymous_variant 0.35 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 591 c.591C>G synonymous_variant 0.39 isoniazid
dnaA 600 c.600T>C synonymous_variant 0.36 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.34 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.4 isoniazid
dnaA 636 c.636C>G synonymous_variant 0.31 isoniazid
dnaA 645 c.645A>G synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.18 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.28 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.28 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.27 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.29 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.35 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.35 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.32 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.23 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.24 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.22 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.2 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.19 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.22 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.2 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.2 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.18 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.28 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.29 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.3 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.35 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.42 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.41 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.38 isoniazid
dnaA 1164 c.1164A>T synonymous_variant 0.31 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 1191 c.1191T>C synonymous_variant 0.32 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.3 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.33 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.31 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.33 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.38 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.38 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.41 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.37 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.36 isoniazid
dnaA 1293 c.1293T>G synonymous_variant 0.37 isoniazid
dnaA 1302 c.1302C>G synonymous_variant 0.37 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.26 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.22 isoniazid
dnaA 1431 c.1431A>G synonymous_variant 0.22 isoniazid
dnaA 1461 c.1461C>A synonymous_variant 0.26 isoniazid
dnaA 1464 c.1464T>C synonymous_variant 0.28 isoniazid
dnaA 1470 c.1470C>G synonymous_variant 0.26 isoniazid
dnaA 1473 c.1473T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 1485 c.1485A>G synonymous_variant 0.19 isoniazid
gyrB 5339 p.Ile34Val missense_variant 0.96 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 5806 c.567C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 5809 c.570C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 5815 c.576C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 5824 c.585A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 5827 c.588G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 5848 c.609G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6123 p.Ala295Gly missense_variant 0.26 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6133 c.894G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6148 c.909C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6169 c.930C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrB 6209 c.970C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.24 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6299 c.1060C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.33 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.22 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7538 c.237G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7883 c.582G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7884 c.583_585delCGTinsGC frameshift_variant&missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 7919 p.Glu206Asp missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 7923 p.His208Tyr missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 7928 p.Asp209Glu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8351 c.1050C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8556 p.Ala419Gln missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8562 c.1261C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8796 c.1495_1497delATCinsGG frameshift_variant&missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8948 p.Leu549Phe missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8951 c.1650G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.28 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9281 c.1980C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9629 c.2328C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9630 p.Val777Ile missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9635 c.2334T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9644 c.2343T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9647 c.2346C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9650 c.2349G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9666 p.Arg789Gly missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9674 c.2373T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9677 c.2376C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9701 c.2400T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9704 c.2403T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9708 c.2407T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9722 c.2421C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9734 c.2433A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
Rv0010c 13903 c.-345A>G upstream_gene_variant 0.18 isoniazid
Rv0010c 13906 c.-348C>T upstream_gene_variant 0.19 isoniazid
Rv0010c 13909 c.-351G>C upstream_gene_variant 0.21 isoniazid
fgd1 490794 c.12G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490797 c.15G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490800 c.18A>C synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490803 c.21T>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 490833 c.51G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 490842 c.60C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491137 p.Glu119Gln missense_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.45 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.4 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491331 c.549G>A synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491364 c.582T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491502 c.720G>A synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491532 c.750G>T synonymous_variant 0.42 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491542 c.760T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491583 c.801G>A synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491595 c.813C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 574616 c.-732G>C upstream_gene_variant 0.21 ethionamide
isoniazid
mshA 574625 c.-723C>G upstream_gene_variant 0.24 ethionamide
isoniazid
mshA 574650 c.-698A>C upstream_gene_variant 0.24 ethionamide
isoniazid
mshA 574655 c.-693C>G upstream_gene_variant 0.24 ethionamide
isoniazid
mshA 574664 c.-684G>C upstream_gene_variant 0.2 ethionamide
isoniazid
mshA 575084 c.-264T>C upstream_gene_variant 0.18 ethionamide
isoniazid
mshA 575536 c.189T>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575542 c.195C>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575561 p.Met72Val missense_variant 0.2 ethionamide
isoniazid
mshA 575569 c.222A>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575571 p.Ser75Thr missense_variant 0.19 ethionamide
isoniazid
mshA 575575 c.228G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575587 c.240C>A synonymous_variant 0.26 ethionamide
isoniazid
mshA 575590 c.243T>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575593 c.246G>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575623 c.276C>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575629 c.282A>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.24 ethionamide
isoniazid Not assoc w R - Interim
mshA 575638 c.291T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575648 p.Val101Gln missense_variant 0.28 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.32 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.32 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.31 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.41 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.45 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.46 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.45 ethionamide
isoniazid
mshA 575767 c.420G>A synonymous_variant 0.42 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.41 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.43 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.45 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.46 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.42 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.38 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.21 ethionamide
isoniazid
ccsA 619502 c.-389_-388delAAinsCG upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619507 c.-384A>G upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>G upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356_-354delCAAinsGCG upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 619558 c.-333G>C upstream_gene_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 619564 c.-327C>G upstream_gene_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.54 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>G upstream_gene_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 619633 c.-258G>A upstream_gene_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 619648 c.-243C>G upstream_gene_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>C upstream_gene_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 619655 c.-236A>G upstream_gene_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 619669 c.-222G>C upstream_gene_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>C upstream_gene_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 619697 c.-194A>C upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620198 p.Gln103Leu missense_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620257 p.Ile123Val missense_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620269 p.Val127Ile missense_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620275 c.385C>T synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.4 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.34 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>C synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620460 c.570T>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620461 p.Val191Ile missense_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620481 c.591T>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620482 p.Val198Leu missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620622 c.732G>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620625 c.735A>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>C synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAC frameshift_variant&missense_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620730 c.840C>T synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620809 c.919C>T synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620829 c.939G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
Rv0565c 656582 p.Leu297Met missense_variant 0.16 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657219 p.Ala84Val missense_variant 0.18 ethionamide
Rv0565c 657222 c.249C>G synonymous_variant 0.18 ethionamide
Rv0565c 657231 c.238_240delATCinsGG frameshift_variant&missense_variant 0.21 ethionamide Uncertain significance
Rv0565c 657237 c.234A>G synonymous_variant 0.3 ethionamide
Rv0565c 657242 p.Glu77Lys missense_variant 0.35 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.31 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.3 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.3 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.29 ethionamide
Rv0565c 657291 c.180C>G synonymous_variant 0.3 ethionamide
Rv0565c 657300 c.171C>T synonymous_variant 0.28 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.17 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.17 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.24 ethionamide
Rv0565c 657656 c.-186C>T upstream_gene_variant 0.22 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.21 ethionamide
Rv0565c 657690 c.-220C>A upstream_gene_variant 0.17 ethionamide
hadA 731732 c.-198G>A upstream_gene_variant 0.15 isoniazid
hadA 731741 c.-189G>A upstream_gene_variant 0.17 isoniazid
hadA 731753 c.-177A>G upstream_gene_variant 0.18 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.23 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.25 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.26 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.26 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.3 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.35 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.36 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.39 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.37 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.37 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.31 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.31 isoniazid
nusG 734078 c.-176C>A upstream_gene_variant 0.19 rifampicin
nusG 734144 c.-110G>C upstream_gene_variant 0.18 rifampicin
nusG 734147 c.-107T>C upstream_gene_variant 0.18 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.19 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.22 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.21 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.2 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.23 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.24 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.27 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.39 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.37 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
nusG 734595 c.342C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
nusG 734634 c.381G>C synonymous_variant 0.22 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.25 rifampicin
nusG 734709 c.456T>G synonymous_variant 0.21 rifampicin
nusG 734715 c.462G>C synonymous_variant 0.2 rifampicin
nusG 734718 c.465G>C synonymous_variant 0.2 rifampicin
nusG 734719 p.Ser156Ala missense_variant 0.2 rifampicin
nusG 734726 p.Arg158Lys missense_variant 0.22 rifampicin
nusG 734732 p.Ala160Val missense_variant 0.19 rifampicin
nusG 734754 c.501G>C synonymous_variant 0.33 rifampicin
nusG 734757 c.504T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734778 c.525G>C synonymous_variant 0.34 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.3 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.25 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.26 rifampicin Uncertain significance
nusG 734820 c.567A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.29 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734832 c.579C>G synonymous_variant 0.3 rifampicin
nusG 734841 c.588G>A synonymous_variant 0.3 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.27 rifampicin
nusG 734853 c.600A>C synonymous_variant 0.27 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.28 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.31 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.28 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.28 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.28 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.21 rifampicin
nusG 734940 c.687G>A synonymous_variant 0.16 rifampicin
rpoB 759606 c.-201T>C upstream_gene_variant 0.32 rifampicin
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760101 c.295T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>T synonymous_variant 0.25 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.28 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.37 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.38 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.46 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.39 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.38 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.38 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.36 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.35 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.35 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.33 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.32 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.27 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.28 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.35 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.34 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.32 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.3 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.21 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.2 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.23 rifampicin
rpoB 760845 p.Thr347Pro missense_variant 0.25 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.26 rifampicin
rpoB 760869 p.Val355Ile missense_variant 0.27 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.22 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.28 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.28 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.34 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.36 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.29 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.24 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.24 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.46 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.44 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.4 rifampicin
rpoB 761213 c.1407G>A synonymous_variant 0.38 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.36 rifampicin
rpoB 761231 c.1425C>G synonymous_variant 0.34 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761301 c.1495C>A synonymous_variant 0.51 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761360 c.1554T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.34 rifampicin
rpoB 761373 p.Val523His missense_variant 0.22 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.19 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.24 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.32 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.24 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.3 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.26 rifampicin
rpoB 761723 c.1917_1919delAGAinsG frameshift_variant&synonymous_variant 0.24 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.28 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.31 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.32 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.3 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.24 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.26 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.24 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.28 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.27 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.23 rifampicin
rpoB 761847 p.Cys681Ser missense_variant 0.18 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.19 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.19 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.17 rifampicin
rpoB 761930 c.2124G>A synonymous_variant 0.23 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.4 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.46 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.45 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.2 rifampicin Uncertain significance
rpoB 762149 c.2343G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.41 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.35 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.27 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.24 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.19 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.2 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.2 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.23 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.19 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 762490 p.Val895Asp missense_variant 0.17 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.25 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.25 rifampicin
rpoC 762521 c.-849C>G upstream_gene_variant 0.24 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.24 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.23 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.23 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.26 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.18 rifampicin Uncertain significance
rpoB 762857 c.3051C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.46 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.63 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.41 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.32 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.25 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.25 rifampicin
rpoB 763206 p.Ser1134Cys missense_variant 0.16 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.34 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.39 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.28 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.37 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.26 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.22 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.22 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.22 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.24 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.25 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.24 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.23 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.25 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.2 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.24 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.22 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.21 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.35 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.4 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.39 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.37 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.35 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.34 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.31 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.41 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.4 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.42 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.39 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.36 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.27 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.22 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.24 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.27 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.31 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.42 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.42 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.34 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.35 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.33 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.33 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.33 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.3 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.34 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.33 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.33 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.25 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.25 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.25 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764470 c.1101C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.28 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.33 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.29 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.32 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.5 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764779 c.1410G>A synonymous_variant 0.41 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.37 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.37 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.43 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.46 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.41 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.21 rifampicin Not assoc w R
rpoC 765034 c.1665T>C synonymous_variant 0.25 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.38 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.38 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765287 c.1918C>T synonymous_variant 0.31 rifampicin
rpoC 765292 c.1923G>T synonymous_variant 0.32 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.34 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.35 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.32 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.33 rifampicin Uncertain significance
rpoC 765349 c.1980T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.38 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.35 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.37 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.36 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.27 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.25 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.43 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.38 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.39 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.43 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.4 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.44 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.38 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.33 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.33 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.26 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.31 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.42 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.43 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.48 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.44 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.4 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.4 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.36 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.28 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.19 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.18 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.19 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.18 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.29 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.4 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.31 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.31 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.36 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.35 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.32 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.35 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.24 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.26 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.25 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.26 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.25 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.23 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.3 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.36 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.36 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.35 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.33 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.33 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.33 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.34 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.31 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.38 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.41 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.33 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.33 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.33 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.26 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.2 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.22 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.27 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.25 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.3 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775975 c.2506T>C synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.22 clofazimine
bedaquiline
mmpL5 776030 c.2451G>C synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781608 c.49_51delAGTinsGC frameshift_variant&missense_variant 0.21 streptomycin Uncertain significance
rpsL 781631 c.72G>C synonymous_variant 0.23 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.26 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.26 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.33 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.34 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.36 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.33 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.31 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.31 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.34 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.33 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.26 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.25 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.2 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.18 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.2 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.27 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.28 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.35 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.35 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.36 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.38 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.41 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.35 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.35 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.38 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.37 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.26 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.27 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.31 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.31 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.31 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.32 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.33 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.31 linezolid
rplC 800794 c.-15_-9delAGATTGGinsGAGTT upstream_gene_variant 0.2 linezolid
rplC 800814 c.6A>G synonymous_variant 0.29 linezolid
rplC 800817 c.9A>T synonymous_variant 0.28 linezolid
rplC 800844 c.36T>C synonymous_variant 0.32 linezolid
rplC 800865 c.57A>G synonymous_variant 0.32 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.3 linezolid
rplC 800874 c.66A>G synonymous_variant 0.28 linezolid
rplC 800877 c.69A>C synonymous_variant 0.25 linezolid
rplC 800880 c.72A>G synonymous_variant 0.24 linezolid
rplC 800889 c.81C>G synonymous_variant 0.29 linezolid
rplC 800907 c.99C>G synonymous_variant 0.3 linezolid
rplC 800916 c.108A>G synonymous_variant 0.31 linezolid
rplC 800937 c.129A>G synonymous_variant 0.31 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.3 linezolid
rplC 800946 c.138T>C synonymous_variant 0.28 linezolid
rplC 800949 c.141T>C synonymous_variant 0.28 linezolid
rplC 800955 c.147C>G synonymous_variant 0.31 linezolid
rplC 800967 c.159C>G synonymous_variant 0.29 linezolid
rplC 800970 c.162T>C synonymous_variant 0.26 linezolid Not assoc w R - Interim
rplC 800982 c.174C>T synonymous_variant 0.25 linezolid
rplC 800985 c.177A>G synonymous_variant 0.22 linezolid
rplC 801132 c.324T>C synonymous_variant 0.18 linezolid
rplC 801150 c.342G>C synonymous_variant 0.19 linezolid
rplC 801153 c.345G>C synonymous_variant 0.19 linezolid
rplC 801156 c.348T>A synonymous_variant 0.19 linezolid
rplC 801171 c.363A>G synonymous_variant 0.32 linezolid
rplC 801174 c.366T>C synonymous_variant 0.33 linezolid
rplC 801222 c.414T>C synonymous_variant 0.37 linezolid
rplC 801228 c.420T>C synonymous_variant 0.35 linezolid
rplC 801246 c.438C>G synonymous_variant 0.33 linezolid
rplC 801249 c.441T>G synonymous_variant 0.37 linezolid
rplC 801255 c.447C>T synonymous_variant 0.35 linezolid
rplC 801267 c.459A>T synonymous_variant 0.26 linezolid
rplC 801270 c.462T>C synonymous_variant 0.23 linezolid
rplC 801276 c.468G>C synonymous_variant 0.21 linezolid
rplC 801279 c.471G>C synonymous_variant 0.18 linezolid
rplC 801312 c.504G>C synonymous_variant 0.17 linezolid
rplC 801348 c.540T>G synonymous_variant 0.19 linezolid
rplC 801357 c.549T>C synonymous_variant 0.22 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.27 linezolid
rplC 801396 c.588T>C synonymous_variant 0.28 linezolid
rplC 801402 c.594T>C synonymous_variant 0.27 linezolid
rplC 801405 c.597T>C synonymous_variant 0.27 linezolid
rplC 801417 c.609T>C synonymous_variant 0.23 linezolid
rplC 801423 c.615G>C synonymous_variant 0.21 linezolid
rplC 801438 c.630T>C synonymous_variant 0.18 linezolid
rplC 801442 p.Ile212Val missense_variant 0.17 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303455 c.525C>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303464 c.534A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303476 c.546G>C synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303509 c.579G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303560 c.630G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303660 p.Val244Thr missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303701 c.771C>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.37 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.62 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304080 p.Ala384Ser missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304628 c.1698G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.25 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.65 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.83 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.66 clofazimine
pretomanid
delamanid
fbiC 1304872 c.1942_1944delAGCinsTCG synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304877 c.1947T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304934 c.2004C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304991 c.2061G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304995 c.2065T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305027 c.2097G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305311 p.Arg794Gln missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1305381 c.2451G>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1305397 p.Glu823Gln missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 0.38 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305420 c.2490C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305423 c.2493T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305430 p.Val834Thr missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305444 c.2514A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305453 c.2523C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
sigE 1364679 c.267T>C synonymous_variant 0.18 pyrazinamide
sigE 1364691 c.279T>C synonymous_variant 0.23 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.27 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.26 pyrazinamide
sigE 1364727 c.315C>T synonymous_variant 0.24 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.25 pyrazinamide
sigE 1364748 c.336G>C synonymous_variant 0.27 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.19 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.28 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.3 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.29 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.33 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.34 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.38 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.4 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.4 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.38 pyrazinamide
sigE 1364866 c.454_456delGCTinsTG frameshift_variant&missense_variant 0.37 pyrazinamide Uncertain significance
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.26 pyrazinamide Uncertain significance
sigE 1364904 p.Asp164Glu missense_variant 0.25 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.18 pyrazinamide
sigE 1364928 c.516C>T synonymous_variant 0.15 pyrazinamide
atpE 1461113 c.69C>T synonymous_variant 0.15 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.18 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.22 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.22 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.24 bedaquiline Uncertain significance
atpE 1461185 c.141G>C synonymous_variant 0.33 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.29 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.31 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.31 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.25 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.22 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.19 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472866 n.1021C>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.65 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476755 n.3098G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476770 n.3113T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476771 n.3114G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
inhA 1673574 c.-628C>G upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.24 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>G upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673610 c.-592C>T upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1673616 c.-586A>G upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.22 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1674280 c.79C>A synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674285 c.84A>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674303 c.102C>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674307 c.106C>T synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674315 c.114C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674321 c.120G>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674342 c.141T>C synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674352 p.Thr51Val missense_variant 0.25 ethionamide
isoniazid
inhA 1674368 p.Ala56Glu missense_variant 0.24 ethionamide
isoniazid
inhA 1674379 c.178C>T synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674382 p.Leu61Ile missense_variant 0.21 ethionamide
isoniazid
inhA 1674387 c.186A>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674399 c.198A>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674461 p.Lys87Arg missense_variant 0.27 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.36 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.35 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674564 c.363C>T synonymous_variant 0.29 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674582 c.381T>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.3 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674639 c.438C>T synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674693 c.492C>G synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674904 c.703_705delGCGinsCC frameshift_variant&missense_variant 0.27 ethionamide
isoniazid
inhA 1674909 c.708G>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674915 c.714C>G synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674942 c.741T>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674957 c.756G>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674963 c.762G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674966 c.765T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674967 p.Asp256Thr missense_variant 0.22 ethionamide
isoniazid
inhA 1674993 c.792G>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674994 p.His265Ser missense_variant 0.21 ethionamide
isoniazid
rpsA 1833367 c.-175G>T upstream_gene_variant 0.16 pyrazinamide
rpsA 1833541 c.-1T>C upstream_gene_variant 0.26 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.31 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.34 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.37 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.41 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.41 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.4 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.42 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.41 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.45 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.45 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.46 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.46 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.45 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.46 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.41 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.25 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.32 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.4 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.46 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.4 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.39 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.28 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.38 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.43 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.41 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.46 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.37 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.34 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.31 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.35 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.36 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.36 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.48 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.46 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.46 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.48 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.48 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.5 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.46 linezolid
tsnR 1853484 c.-122_-121delAGinsGC upstream_gene_variant 0.47 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.43 linezolid
tsnR 1853498 c.-108G>C upstream_gene_variant 0.41 linezolid
tsnR 1853531 c.-75A>G upstream_gene_variant 0.28 linezolid
tsnR 1853540 c.-66A>G upstream_gene_variant 0.23 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917951 c.12T>C synonymous_variant 0.19 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917981 c.42G>C synonymous_variant 0.18 capreomycin
tlyA 1918464 c.525C>G synonymous_variant 0.19 capreomycin
tlyA 1918476 c.537A>C synonymous_variant 0.22 capreomycin
tlyA 1918477 p.Leu180Met missense_variant 0.22 capreomycin
bacA 2064912 c.-184A>G upstream_gene_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064936 c.-208C>A upstream_gene_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064945 c.-217G>A upstream_gene_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064963 c.-235G>C upstream_gene_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101960 c.1083A>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101966 c.1077T>G synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101978 c.1063_1065delAACinsGT frameshift_variant&missense_variant 0.2 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2101988 p.Ala352Gly missense_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102009 p.Ser345Asn missense_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102020 c.1023A>G synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102023 c.1020G>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102026 c.1017G>C synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102050 c.993T>C synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2102053 c.990G>C synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2102059 c.984T>C synonymous_variant 0.23 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102065 c.978G>C synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102068 c.975T>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102076 p.Met323Leu missense_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102077 c.966T>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102083 c.958_960delGTGinsAC frameshift_variant&missense_variant 0.24 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102092 c.951G>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102098 c.945G>C synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102103 p.Tyr314His missense_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102104 c.939G>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102110 c.933T>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102133 p.Gln304Lys missense_variant 0.15 ethionamide
delamanid
isoniazid
ndh 2102218 c.825C>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2102233 c.810G>A synonymous_variant 0.33 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102242 c.801G>A synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102305 c.738T>C synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2102317 c.726A>G synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102596 c.447C>G synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102599 c.444T>C synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102604 p.Leu147Val missense_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102608 c.433_435delTTGinsCC frameshift_variant&missense_variant 0.24 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155020 c.1092C>T synonymous_variant 0.21 isoniazid
katG 2155029 c.1083C>G synonymous_variant 0.23 isoniazid
katG 2155032 c.1080T>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
katG 2155054 p.Tyr353Phe missense_variant 0.35 isoniazid
katG 2155056 c.1056A>G synonymous_variant 0.34 isoniazid
katG 2155062 c.1050T>C synonymous_variant 0.36 isoniazid
katG 2155065 c.1047C>G synonymous_variant 0.35 isoniazid
katG 2155068 c.1044T>C synonymous_variant 0.35 isoniazid
katG 2155071 c.1041T>C synonymous_variant 0.35 isoniazid
katG 2155080 c.1032G>C synonymous_variant 0.34 isoniazid
katG 2155113 c.999C>G synonymous_variant 0.2 isoniazid
katG 2155590 c.522A>G synonymous_variant 0.2 isoniazid
katG 2155617 c.495T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
katG 2155632 c.480A>C synonymous_variant 0.29 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.31 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.32 isoniazid Uncertain significance
katG 2155677 c.435C>G synonymous_variant 0.26 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.26 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.24 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.22 isoniazid
katG 2155701 c.411C>T synonymous_variant 0.23 isoniazid Not assoc w R - Interim
katG 2155704 c.408C>G synonymous_variant 0.23 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.21 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.22 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.24 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.24 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.27 pyrazinamide
pncA 2290006 c.-765T>C upstream_gene_variant 0.26 pyrazinamide
pncA 2290009 c.-768A>G upstream_gene_variant 0.25 pyrazinamide
pncA 2290015 c.-774A>C upstream_gene_variant 0.24 pyrazinamide
pncA 2290027 c.-786G>A upstream_gene_variant 0.23 pyrazinamide
kasA 2517947 c.-168C>T upstream_gene_variant 0.48 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.4 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.33 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.33 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.25 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.25 isoniazid
kasA 2518031 c.-84G>T upstream_gene_variant 0.2 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.16 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.19 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.25 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.25 isoniazid
kasA 2518222 c.108G>A synonymous_variant 0.21 isoniazid
kasA 2518223 c.109_111delTTGinsCC frameshift_variant&missense_variant 0.21 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.2 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.21 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.2 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.27 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.27 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.3 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.32 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.34 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.34 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.33 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.35 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.34 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.36 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.33 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.44 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.49 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.51 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.5 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.47 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.48 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.49 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.48 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.36 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.37 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.41 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.32 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.33 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.31 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.43 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.48 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.41 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.41 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.4 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.4 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.41 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.36 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.3 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.27 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.24 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.18 isoniazid
kasA 2519095 c.981C>G synonymous_variant 0.2 isoniazid
kasA 2519098 c.984C>G synonymous_variant 0.18 isoniazid
kasA 2519104 c.990T>A synonymous_variant 0.16 isoniazid
kasA 2519111 p.Gln333Glu missense_variant 0.18 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.21 isoniazid
kasA 2519125 c.1011C>T synonymous_variant 0.2 isoniazid
kasA 2519137 c.1023T>C synonymous_variant 0.22 isoniazid
kasA 2519146 c.1032C>A synonymous_variant 0.23 isoniazid
kasA 2519167 c.1053T>C synonymous_variant 0.28 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.31 isoniazid
kasA 2519176 c.1062G>A synonymous_variant 0.3 isoniazid
kasA 2519197 c.1083G>C synonymous_variant 0.3 isoniazid
kasA 2519215 c.1101C>T synonymous_variant 0.27 isoniazid
kasA 2519221 c.1107G>C synonymous_variant 0.22 isoniazid
kasA 2519225 c.1111C>T synonymous_variant 0.18 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
ahpC 2726288 c.96C>T synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ahpC 2726354 c.162G>C synonymous_variant 0.18 isoniazid
ahpC 2726357 c.165A>G synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ahpC 2726564 c.372C>T synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ahpC 2726579 c.387T>C synonymous_variant 0.22 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.28 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.28 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.32 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.36 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.3 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.28 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.25 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.22 isoniazid Not assoc w R - Interim
ahpC 2726681 c.489A>G synonymous_variant 0.21 isoniazid
ahpC 2726687 c.495C>G synonymous_variant 0.19 isoniazid
folC 2746979 p.Ala207Asp missense_variant 0.17 para-aminosalicylic_acid
folC 2746987 c.612T>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747007 p.Ser198Cys missense_variant 0.16 para-aminosalicylic_acid
folC 2747023 c.576C>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747032 c.567A>C synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747040 p.Ile187Val missense_variant 0.26 para-aminosalicylic_acid
folC 2747059 c.540T>C synonymous_variant 0.29 para-aminosalicylic_acid
folC 2747065 c.534C>G synonymous_variant 0.28 para-aminosalicylic_acid
folC 2747086 c.513A>C synonymous_variant 0.31 para-aminosalicylic_acid
folC 2747089 c.510G>C synonymous_variant 0.3 para-aminosalicylic_acid
folC 2747098 c.501C>G synonymous_variant 0.28 para-aminosalicylic_acid
folC 2747101 c.498G>C synonymous_variant 0.29 para-aminosalicylic_acid
folC 2747107 c.492G>C synonymous_variant 0.29 para-aminosalicylic_acid
folC 2747110 c.489T>C synonymous_variant 0.27 para-aminosalicylic_acid
folC 2747113 c.486C>G synonymous_variant 0.27 para-aminosalicylic_acid
folC 2747116 c.483G>C synonymous_variant 0.27 para-aminosalicylic_acid
folC 2747275 c.324T>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747281 c.318A>G synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.25 para-aminosalicylic_acid
folC 2747290 c.309A>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.27 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.34 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.37 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.38 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.28 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.25 para-aminosalicylic_acid
Rv2477c 2782447 c.1596C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782450 c.1593C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 c.1590C>A synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782498 c.1545C>T synonymous_variant 0.59 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
Rv2477c 2782510 c.1533G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783243 p.Thr267Ser missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783320 c.723C>T synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783332 c.711T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783365 c.678C>T synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783373 p.Glu224Gln missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783416 c.625_627delATCinsGG frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783422 c.621T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.616_618delCCCinsGG frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783432 p.Ser204Ala missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783434 c.609C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin