TB-Profiler result

Run: ERR4820854
Summary

Run ID: ERR4820854

Sample name:

Date: 2024-04-16T12:36:57.099019

Number of reads: 1582476

Percentage reads mapped: 52.97

Median coverage: 33.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.97
lineage4.1.2 Euro-American None 0.97
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.95
lineage4 Euro-American None 0.95
lineage6.2.3 West-Africa 2 RD702 0.06
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide panD p.Val138Ala Mutation from literature
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.604_606delTCGinsGC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303534 c.604_606delTCGinsGC frameshift_variant&missense_variant 0.35 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.37 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
panD 4043869 p.Val138Ala missense_variant 0.29 pyrazinamide Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.23 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 30 c.30C>G synonymous_variant 0.38 isoniazid
dnaA 414 c.414G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
dnaA 612 c.612G>C synonymous_variant 0.25 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.25 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.32 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.33 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.38 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.33 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.33 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.32 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.35 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.39 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 897 c.897A>G synonymous_variant 0.44 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.42 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.45 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.45 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.47 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.41 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.39 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.41 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.38 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.3 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.33 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.29 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.48 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.5 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.48 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.43 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.4 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.44 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.29 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.31 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.25 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.33 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.32 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.32 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.32 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.33 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.36 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.32 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.29 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.23 isoniazid
gyrB 5806 c.567C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 5824 c.585A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 5827 c.588G>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 5849 c.610C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 5854 c.615C>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.29 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6418 c.-884C>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.51 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.57 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.56 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.48 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.45 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.49 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.32 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7216 c.1977G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7228 c.-74C>T upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7234 c.1995C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7246 c.2007T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7324 c.23_24insAGG disruptive_inframe_insertion 0.24 levofloxacin
moxifloxacin
gyrA 7334 c.33G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7335 p.Leu12Val missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 7347 c.46_48delGAAinsCG frameshift_variant&missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCC frameshift_variant&missense_variant 0.6 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7697 c.396C>A synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7814 c.513C>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7823 c.522G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7853 c.552C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8096 c.795T>A synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.33 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8367 c.1066C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8762 c.1461G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.38 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.5 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.49 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.3 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9104 c.1803C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>A synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.41 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9153 p.Thr618Glu missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 c.2007C>T synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9312 c.2011C>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9317 c.2016G>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9413 c.2112G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
Rv0010c 13903 c.-345A>G upstream_gene_variant 0.29 isoniazid
Rv0010c 13909 c.-351G>C upstream_gene_variant 0.3 isoniazid
fgd1 490782 c.-1G>C upstream_gene_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 490797 c.15G>A synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 490800 c.18A>C synonymous_variant 0.31 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490803 c.21T>A synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.35 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491001 c.219G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491337 c.555C>G synonymous_variant 0.3 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491340 c.558C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.32 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491526 c.744T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491535 c.753G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491553 c.771G>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491591 p.Lys270Met missense_variant 0.62 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
fgd1 491601 c.819T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
mshA 575649 p.Val101Ala missense_variant 0.19 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575662 c.315C>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575665 c.318G>A synonymous_variant 0.23 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.25 ethionamide
isoniazid
mshA 575679 p.Asn111Ser missense_variant 0.73 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575695 c.348C>G synonymous_variant 0.2 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.19 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.22 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.23 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.25 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.31 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.3 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.28 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575809 c.462C>T synonymous_variant 0.35 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.37 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.38 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.36 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.36 ethionamide
isoniazid
mshA 575833 c.486C>G synonymous_variant 0.34 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.32 ethionamide
isoniazid Not assoc w R - Interim
mshA 575884 c.537G>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.32 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.31 ethionamide
isoniazid
mshA 575917 p.Asp190Glu missense_variant 0.28 ethionamide
isoniazid
mshA 575920 c.573C>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575924 p.Gly193Ser missense_variant 0.25 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575950 c.603C>G synonymous_variant 0.23 ethionamide
isoniazid
ccsA 619543 c.-348C>G upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 619561 c.-330G>C upstream_gene_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620286 c.396G>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>T synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.31 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620424 c.534G>C synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620433 c.543C>G synonymous_variant 0.27 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAA frameshift_variant&missense_variant 0.22 capreomycin
amikacin
kanamycin
Rv0565c 656052 c.1419A>C synonymous_variant 0.29 ethionamide
Rv0565c 656073 c.1396_1398delTTGinsCC frameshift_variant&missense_variant 0.29 ethionamide Uncertain significance
Rv0565c 656076 c.1395C>T synonymous_variant 0.25 ethionamide
Rv0565c 656085 c.1386A>G synonymous_variant 0.26 ethionamide
Rv0565c 656088 c.1383A>G synonymous_variant 0.26 ethionamide
Rv0565c 656091 c.1380T>C synonymous_variant 0.26 ethionamide
Rv0565c 656112 c.1359C>G synonymous_variant 0.23 ethionamide
Rv0565c 656265 c.1206G>C synonymous_variant 0.33 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.32 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.29 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.24 ethionamide
Rv0565c 656298 c.1173G>C synonymous_variant 0.25 ethionamide
Rv0565c 656412 c.1059T>G synonymous_variant 0.31 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.31 ethionamide
Rv0565c 656448 c.1021_1023delATTinsGC frameshift_variant&missense_variant 0.34 ethionamide Uncertain significance
Rv0565c 656454 c.1017G>C synonymous_variant 0.41 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.43 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.41 ethionamide
Rv0565c 656475 c.996A>G synonymous_variant 0.43 ethionamide
Rv0565c 656484 c.987T>C synonymous_variant 0.41 ethionamide
Rv0565c 656487 c.984T>C synonymous_variant 0.36 ethionamide Not assoc w R - Interim
Rv0565c 656493 c.978C>G synonymous_variant 0.39 ethionamide
Rv0565c 656502 c.969C>T synonymous_variant 0.38 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.38 ethionamide Not assoc w R - Interim
Rv0565c 657259 p.Tyr71Phe missense_variant 0.26 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.26 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.29 ethionamide
Rv0565c 657267 c.202_204delTCGinsCC frameshift_variant&synonymous_variant 0.26 ethionamide Uncertain significance
Rv0565c 657300 c.171C>G synonymous_variant 0.41 ethionamide
Rv0565c 657303 c.168C>T synonymous_variant 0.44 ethionamide Not assoc w R - Interim
Rv0565c 657318 c.153T>C synonymous_variant 0.38 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.36 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.35 ethionamide
Rv0565c 657348 c.123A>G synonymous_variant 0.25 ethionamide
Rv0565c 657356 p.Ile39Val missense_variant 0.29 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.29 ethionamide
Rv0565c 657592 c.-122A>C upstream_gene_variant 0.35 ethionamide
Rv0565c 657600 c.-132_-131delCA upstream_gene_variant 0.38 ethionamide
Rv0565c 657606 c.-136T>G upstream_gene_variant 0.45 ethionamide
Rv0565c 657607 c.-138_-137insCA upstream_gene_variant 0.4 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.54 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.52 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.5 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.48 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.5 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.38 ethionamide
hadA 731747 c.-183T>C upstream_gene_variant 0.29 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.33 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.32 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.33 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.32 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.26 isoniazid
hadA 732253 c.324T>C synonymous_variant 0.23 isoniazid
hadA 732259 c.330T>C synonymous_variant 0.24 isoniazid
hadA 732268 c.339T>G synonymous_variant 0.25 isoniazid
hadA 732270 p.Glu114Val missense_variant 0.25 isoniazid
hadA 732272 p.Ala115Ser missense_variant 0.25 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.33 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.32 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.34 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.41 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.39 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.38 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.47 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.44 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.43 isoniazid
nusG 734078 c.-176C>G upstream_gene_variant 0.3 rifampicin Uncertain significance
nusG 734093 c.-161A>C upstream_gene_variant 0.27 rifampicin
nusG 734102 c.-152G>C upstream_gene_variant 0.28 rifampicin
nusG 734111 c.-143A>G upstream_gene_variant 0.25 rifampicin
nusG 734114 c.-140A>G upstream_gene_variant 0.25 rifampicin
nusG 734120 c.-134T>C upstream_gene_variant 0.24 rifampicin Uncertain significance
nusG 734123 c.-131C>G upstream_gene_variant 0.21 rifampicin
nusG 734129 c.-125G>C upstream_gene_variant 0.21 rifampicin
nusG 734132 c.-122G>C upstream_gene_variant 0.23 rifampicin
nusG 734135 c.-119G>C upstream_gene_variant 0.23 rifampicin
nusG 734144 c.-110G>C upstream_gene_variant 0.2 rifampicin
nusG 734147 c.-107T>C upstream_gene_variant 0.21 rifampicin
nusG 734364 c.111G>C synonymous_variant 0.2 rifampicin
nusG 734370 c.117A>G synonymous_variant 0.23 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.27 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.34 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.35 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.39 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.49 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.5 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.47 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.41 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.41 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.41 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.44 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.41 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.43 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.48 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.26 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.71 rifampicin Not assoc w R
rpoB 760118 c.312T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.34 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.34 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.35 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.43 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.44 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.49 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.49 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.54 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.55 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.55 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.68 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.65 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.45 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.44 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.49 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.47 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.44 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.4 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.21 rifampicin
rpoB 760869 p.Val355Ile missense_variant 0.25 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.26 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.37 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.37 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.39 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.6 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.71 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.52 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.52 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.53 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.51 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.49 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.48 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.44 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.44 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.42 rifampicin
rpoB 761373 p.Val523His missense_variant 0.37 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.24 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.21 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.28 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.57 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.62 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.59 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.56 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.47 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.45 rifampicin
rpoB 761728 c.1923dupC frameshift_variant 0.45 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.48 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.52 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.49 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.44 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.35 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.36 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.21 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.25 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.25 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.29 rifampicin
rpoB 761849 p.Cys681Trp missense_variant 0.2 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.21 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.25 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.31 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.33 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.53 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.55 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.51 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.56 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.56 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.6 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.45 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.45 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.46 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.5 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.44 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.47 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.48 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.47 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.37 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.35 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.4 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.37 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.44 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.42 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.31 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.46 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.46 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.43 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.37 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.37 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.35 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.34 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.24 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.25 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.28 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.38 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.4 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.4 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762926 c.3120C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.52 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.53 rifampicin
rpoC 763025 c.-345C>T upstream_gene_variant 0.57 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.61 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.53 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.31 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.19 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763256 c.-114G>A upstream_gene_variant 0.21 rifampicin
rpoC 763351 c.-19T>C upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoC 763352 c.-18T>A upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoC 763402 c.33C>G synonymous_variant 0.47 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.48 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.51 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.4 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.55 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.42 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.46 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.45 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.46 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.58 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.57 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.54 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.39 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.2 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.27 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763963 c.594C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.28 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.38 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.44 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.45 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.47 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.51 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.51 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.44 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.45 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.48 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.48 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.41 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.45 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.57 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.54 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.44 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.44 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.48 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.56 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.61 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.56 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.39 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.4 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.37 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.37 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.37 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.46 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.51 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.51 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.53 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.59 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.59 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.67 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.58 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.49 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.39 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.4 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.3 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.32 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.9 rifampicin Not assoc w R
rpoC 765292 c.1923G>C synonymous_variant 0.31 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.33 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.33 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.37 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.39 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.44 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.35 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.34 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.37 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.5 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.54 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.44 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.43 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.45 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.55 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.53 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.41 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.39 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.35 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.42 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.42 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.42 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.56 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.53 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.48 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.37 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.38 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.39 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.38 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.38 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.48 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.44 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.48 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.44 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.33 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.29 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.29 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.33 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.33 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.34 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.37 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.37 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.46 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.55 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.53 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.47 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.47 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.48 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.4 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.41 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.39 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.38 rifampicin
rpoC 766549 c.3180G>T synonymous_variant 0.38 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.39 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.35 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.34 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.35 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.36 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.44 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.46 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.41 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.43 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.44 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.44 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.44 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.46 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.46 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.49 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.55 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.55 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.54 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.58 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.56 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.52 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.4 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.43 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.46 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.47 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.52 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.47 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.43 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.22 rifampicin
rpoC 767275 c.3906T>C synonymous_variant 0.22 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.22 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>T synonymous_variant 0.22 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777116 c.1365C>T synonymous_variant 0.25 clofazimine
bedaquiline
mmpL5 777133 p.Val450Ile missense_variant 0.29 clofazimine
bedaquiline
mmpL5 777158 c.1323C>G synonymous_variant 0.35 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 777170 c.1311T>C synonymous_variant 0.38 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.39 clofazimine
bedaquiline
mmpL5 777191 c.1290C>G synonymous_variant 0.27 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.42 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.37 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.38 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.47 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.41 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.38 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.4 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.43 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.45 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.46 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.5 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.5 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.47 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.51 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.52 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.53 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.53 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.46 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.46 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.42 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.4 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.43 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.35 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.34 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.35 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.34 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.44 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.5 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.54 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.56 streptomycin Uncertain significance
rplC 800537 c.-272C>T upstream_gene_variant 0.38 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.39 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.43 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.44 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.49 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.38 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.38 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.44 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.39 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.38 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.43 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.41 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.35 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.35 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.38 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.39 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.36 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.28 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.28 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.3 linezolid
rplC 800814 c.6A>G synonymous_variant 0.33 linezolid
rplC 800817 c.9A>T synonymous_variant 0.35 linezolid
rplC 800844 c.36T>C synonymous_variant 0.33 linezolid
rplC 801127 p.Ala107Thr missense_variant 0.2 linezolid
rplC 801132 c.324T>C synonymous_variant 0.32 linezolid
rplC 801147 c.339T>C synonymous_variant 0.33 linezolid
rplC 801150 c.342G>C synonymous_variant 0.33 linezolid
rplC 801153 c.345G>C synonymous_variant 0.36 linezolid
rplC 801156 c.348T>A synonymous_variant 0.34 linezolid
rplC 801168 c.360C>G synonymous_variant 0.42 linezolid
rplC 801171 c.363A>G synonymous_variant 0.42 linezolid
rplC 801174 c.366T>C synonymous_variant 0.44 linezolid
rplC 801195 c.387G>C synonymous_variant 0.51 linezolid
rplC 801207 c.399C>T synonymous_variant 0.58 linezolid
rplC 801246 c.438C>T synonymous_variant 0.29 linezolid
rplC 801249 c.441T>C synonymous_variant 0.29 linezolid
rplC 801255 c.447C>T synonymous_variant 0.25 linezolid
rplC 801264 c.456C>T synonymous_variant 0.22 linezolid
rplC 801267 c.459A>T synonymous_variant 0.21 linezolid
rplC 801276 c.468G>C synonymous_variant 0.2 linezolid
rplC 801279 c.471G>C synonymous_variant 0.21 linezolid
rplC 801282 c.474G>C synonymous_variant 0.2 linezolid
rplC 801285 c.477G>C synonymous_variant 0.2 linezolid
rplC 801300 c.492C>G synonymous_variant 0.24 linezolid
rplC 801309 c.501C>G synonymous_variant 0.23 linezolid
rplC 801312 c.504G>C synonymous_variant 0.24 linezolid
rplC 801321 c.513C>T synonymous_variant 0.3 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.28 linezolid
rplC 801339 c.531T>C synonymous_variant 0.24 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.25 linezolid
rplC 801348 c.540T>G synonymous_variant 0.27 linezolid
rplC 801357 c.549T>C synonymous_variant 0.29 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.39 linezolid
rplC 801402 c.594T>C synonymous_variant 0.33 linezolid
rplC 801405 c.597T>C synonymous_variant 0.31 linezolid
rplC 801423 c.615G>C synonymous_variant 0.3 linezolid
rplC 801426 c.618C>G synonymous_variant 0.31 linezolid
rplC 801427 p.Met207Val missense_variant 0.31 linezolid
rplC 801438 c.630T>C synonymous_variant 0.31 linezolid
rplC 801442 p.Ile212Val missense_variant 0.36 linezolid
fbiC 1303501 c.571C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303521 c.591C>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303530 c.600G>A synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.3 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304161 p.Arg411Ser missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304169 c.1239T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304174 p.Val415Ala missense_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304187 c.1257T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304208 c.1278C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304739 c.1809C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.6 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304862 c.1932G>A synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.65 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305372 c.2442G>A synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305384 c.2454G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305417 c.2487C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
sigE 1365042 c.630G>C synonymous_variant 0.19 pyrazinamide
sigE 1365057 c.645C>T synonymous_variant 0.18 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.73 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476707 n.3050C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
inhA 1673523 c.-679G>T upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.27 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.26 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.27 ethionamide
isoniazid
inhA 1673679 c.-523T>C upstream_gene_variant 0.26 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673685 c.-517C>T upstream_gene_variant 0.28 ethionamide
isoniazid
fabG1 1673710 p.Leu91Ile missense_variant 0.33 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.28 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.21 ethionamide
isoniazid
fabG1 1673750 p.Lys104Arg missense_variant 0.21 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 0.24 ethionamide
isoniazid
inhA 1673916 c.-286A>C upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.23 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.33 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.35 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.46 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.39 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.39 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.48 ethionamide
isoniazid
inhA 1674504 c.303C>G synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.39 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.45 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.36 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.36 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674888 c.687C>G synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.43 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674954 c.753G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674960 c.759C>G synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674966 c.765T>G synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674967 p.Asp256Thr missense_variant 0.31 ethionamide
isoniazid
rpsA 1833532 c.-10A>C upstream_gene_variant 0.21 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.27 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.4 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.63 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.54 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.53 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.53 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.54 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.57 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.55 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.57 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.45 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.42 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.43 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.41 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.47 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.51 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.59 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.65 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.65 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.63 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.66 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.56 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.49 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.38 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.55 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.58 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.55 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.63 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.66 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.56 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.56 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.49 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.43 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.4 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.46 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.5 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.55 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.53 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.55 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.54 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.51 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.25 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.28 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.32 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.33 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.35 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.34 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.34 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.36 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.27 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917975 c.36C>G synonymous_variant 0.27 capreomycin
tlyA 1917981 c.42G>C synonymous_variant 0.28 capreomycin
tlyA 1917990 c.51G>C synonymous_variant 0.27 capreomycin
tlyA 1917993 c.54A>G synonymous_variant 0.28 capreomycin Not assoc w R - Interim
tlyA 1917996 c.57A>G synonymous_variant 0.28 capreomycin
tlyA 1918002 c.63A>G synonymous_variant 0.27 capreomycin
tlyA 1918036 p.Arg33Ser missense_variant 0.17 capreomycin
bacA 2064903 c.-175G>A upstream_gene_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064912 c.-184A>G upstream_gene_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064915 c.-187G>C upstream_gene_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064936 c.-208C>G upstream_gene_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064942 c.-214G>A upstream_gene_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101756 c.1287G>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101765 c.1278C>G synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2101768 c.1275C>A synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2101771 c.1272T>G synonymous_variant 0.26 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2101774 c.1269T>C synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2101777 c.1266C>G synonymous_variant 0.25 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2101783 c.1260T>G synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2101804 c.1239T>G synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2101808 p.Thr412Ser missense_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2101830 p.Ile405Val missense_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2101837 p.Ala402Val missense_variant 0.23 ethionamide Uncertain significance
delamanid
isoniazid Uncertain significance
ndh 2101888 c.1155T>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101894 c.1149T>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101912 c.1131G>C synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2101920 c.1123A>C synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2101924 c.1119T>G synonymous_variant 0.36 ethionamide
delamanid
isoniazid
ndh 2101939 c.1104A>G synonymous_variant 0.42 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.47 ethionamide
delamanid
isoniazid
ndh 2101963 c.1080G>A synonymous_variant 0.48 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101966 c.1077T>G synonymous_variant 0.47 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.43 ethionamide
delamanid
isoniazid
ndh 2101988 p.Ala352Asp missense_variant 0.38 ethionamide
delamanid
isoniazid
ndh 2101990 c.1053G>C synonymous_variant 0.37 ethionamide
delamanid
isoniazid
ndh 2101993 c.1050A>G synonymous_variant 0.38 ethionamide
delamanid
isoniazid
ndh 2102014 c.1029C>G synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102020 c.1023A>G synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102023 c.1020G>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102026 c.1017G>C synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102218 c.825C>A synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102227 c.816C>T synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102230 c.813G>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102233 c.810G>A synonymous_variant 0.26 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102302 c.741G>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102305 c.738T>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289930 c.-689A>G upstream_gene_variant 0.38 pyrazinamide
pncA 2289943 c.-702T>G upstream_gene_variant 0.33 pyrazinamide
pncA 2289948 c.-707C>T upstream_gene_variant 0.35 pyrazinamide
pncA 2289949 c.-708A>G upstream_gene_variant 0.33 pyrazinamide
pncA 2289987 c.-746C>T upstream_gene_variant 0.24 pyrazinamide
pncA 2289988 c.-747G>C upstream_gene_variant 0.23 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.27 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.23 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.23 pyrazinamide
pncA 2290000 c.-759C>T upstream_gene_variant 0.22 pyrazinamide
pncA 2290009 c.-768A>C upstream_gene_variant 0.43 pyrazinamide
pncA 2290015 c.-774A>C upstream_gene_variant 0.5 pyrazinamide
pncA 2290024 c.-783C>G upstream_gene_variant 0.47 pyrazinamide
pncA 2290030 c.-791_-789delAATinsCC upstream_gene_variant 0.47 pyrazinamide
pncA 2290033 c.-792C>G upstream_gene_variant 0.47 pyrazinamide
pncA 2290038 c.-797G>A upstream_gene_variant 0.43 pyrazinamide
pncA 2290042 c.-801T>C upstream_gene_variant 0.46 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.61 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.51 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.47 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.26 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.27 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.3 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.34 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.42 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.49 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.51 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.51 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.46 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.31 isoniazid
kasA 2518447 c.333T>G synonymous_variant 0.24 isoniazid
kasA 2518459 c.345T>C synonymous_variant 0.2 isoniazid
kasA 2518462 c.348A>C synonymous_variant 0.22 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.21 isoniazid
kasA 2518474 c.360G>A synonymous_variant 0.24 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.24 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.27 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.24 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.23 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.28 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.29 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.27 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.28 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.26 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.26 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.24 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.25 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.27 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.29 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.25 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.15 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.18 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.18 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.24 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.28 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.28 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.28 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.33 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.34 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.35 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.33 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.33 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.35 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.4 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.35 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.29 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.3 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.31 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.27 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.27 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.3 isoniazid
kasA 2518927 c.813C>G synonymous_variant 0.29 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.25 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.22 isoniazid
kasA 2518951 c.837G>C synonymous_variant 0.24 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.28 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.28 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.26 isoniazid
kasA 2518975 c.861C>G synonymous_variant 0.27 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.28 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.35 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.37 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.37 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.37 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.38 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.4 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.43 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.41 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.37 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.34 isoniazid
ahpC 2726258 c.66C>T synonymous_variant 0.24 isoniazid Not assoc w R - Interim
ahpC 2726303 c.111T>C synonymous_variant 0.35 isoniazid
ahpC 2726311 p.Ser40Asn missense_variant 0.26 isoniazid
ahpC 2726315 p.Asp41Glu missense_variant 0.25 isoniazid
ahpC 2726318 p.Glu42Asp missense_variant 0.26 isoniazid
ahpC 2726322 c.130_132delCCAinsGC frameshift_variant&missense_variant 0.26 isoniazid Uncertain significance
ahpC 2726330 c.138G>A synonymous_variant 0.28 isoniazid Not assoc w R - Interim
ahpC 2726336 c.144G>C synonymous_variant 0.28 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.26 isoniazid
ahpC 2726357 c.165A>G synonymous_variant 0.3 isoniazid Not assoc w R - Interim
ahpC 2726579 c.387T>C synonymous_variant 0.24 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.23 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.23 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.27 isoniazid
ahpC 2726601 p.Ile137Leu missense_variant 0.27 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.42 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.44 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.38 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.31 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.31 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.32 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.32 isoniazid Not assoc w R - Interim
ahpC 2726693 c.501C>G synonymous_variant 0.31 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.29 isoniazid
folC 2746375 c.1224G>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747745 c.-147A>C upstream_gene_variant 0.31 para-aminosalicylic_acid
folC 2747751 c.-154_-153delGCinsCG upstream_gene_variant 0.34 para-aminosalicylic_acid
folC 2747759 c.-161T>C upstream_gene_variant 0.32 para-aminosalicylic_acid
folC 2747760 c.-162G>T upstream_gene_variant 0.32 para-aminosalicylic_acid
folC 2747772 c.-174C>G upstream_gene_variant 0.31 para-aminosalicylic_acid
folC 2747790 c.-192G>C upstream_gene_variant 0.32 para-aminosalicylic_acid
Rv2477c 2782861 c.1182T>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.35 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.56 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.54 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.57 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.51 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.53 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.58 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.57 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.62 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783179 c.864G>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783209 c.834G>A synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.5 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 c.544_546delTTGinsCC frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783502 c.541T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783521 c.522G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.47 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.54 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.53 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.43 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784411 c.-369G>C upstream_gene_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784452 c.-410C>T upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784454 c.-412G>A upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ribD 2987046 p.Val70Ile missense_variant 0.2 para-aminosalicylic_acid
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.24 capreomycin Uncertain significance
Rv2752c 3064838 c.1354T>C synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064860 c.1332G>C synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064872 c.1320T>G synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064877 p.Ser439Ala missense_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064881 p.Ser437Ala missense_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064887 c.1305A>G synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064893 c.1299C>G synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064896 c.1296T>C synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065183 p.Ser337Ala missense_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065186 c.1006T>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065196 c.996T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065202 c.990T>G synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065205 c.987T>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065223 c.969T>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065412 c.780G>A synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065418 c.774A>G synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065421 c.771G>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065442 c.750T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065451 c.741G>A synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065457 c.735A>C synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065463 c.729T>C synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065946 p.Gly82Ala missense_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065955 c.235_237delTTGinsCC frameshift_variant&missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065979 c.213T>C synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.32 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066009 c.183G>C synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066018 c.174T>C synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>G synonymous_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066074 c.118C>T synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066078 c.114C>T synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066102 c.90C>T synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066309 c.-118T>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066315 c.-124C>T upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066330 c.-139G>C upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066335 c.-144T>C upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066339 c.-148G>C upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066360 c.-169T>C upstream_gene_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066369 c.-180_-178delAGCinsGCG upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066380 c.-189A>G upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066396 c.-207_-205delGCGinsAC upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066399 c.-210_-208delATTinsTCC upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066810 c.-619G>A upstream_gene_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067274 c.672C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067277 c.669C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067281 p.Val222Ala missense_variant 0.26 para-aminosalicylic_acid
thyX 3067284 p.Ala221Gly missense_variant 0.23 para-aminosalicylic_acid
thyX 3067286 c.660C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067292 c.654G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067295 c.651C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067376 c.570G>A synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.44 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.38 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.34 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.33 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.31 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.28 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.33 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.32 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.44 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.36 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.41 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.54 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.49 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067736 c.208_210delTTCinsCT frameshift_variant&missense_variant 0.38 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.29 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.32 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067781 c.165C>A synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.55 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.48 para-aminosalicylic_acid
thyX 3067935 p.Thr4Ile missense_variant 0.43 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.33 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.38 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.32 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087272 c.453A>C synonymous_variant 0.18 cycloserine
ald 3087278 p.Gln153His missense_variant 0.22 cycloserine
ald 3087281 c.462G>C synonymous_variant 0.21 cycloserine
ald 3087284 c.465C>G synonymous_variant 0.23 cycloserine
ald 3087290 c.471T>C synonymous_variant 0.27 cycloserine
ald 3087305 c.486G>C synonymous_variant 0.42 cycloserine
ald 3087311 c.492C>G synonymous_variant 0.41 cycloserine
ald 3087318 c.499_501delGAAinsAG frameshift_variant&missense_variant 0.38 cycloserine
ald 3087344 c.525C>G synonymous_variant 0.39 cycloserine
ald 3087347 c.528C>G synonymous_variant 0.38 cycloserine
ald 3087356 c.537C>G synonymous_variant 0.42 cycloserine
ald 3087368 c.549A>G synonymous_variant 0.3 cycloserine
ald 3087375 p.Ile186Val missense_variant 0.27 cycloserine
ald 3087380 c.561C>G synonymous_variant 0.27 cycloserine
whiB7 3569166 c.-487C>G upstream_gene_variant 0.21 streptomycin
amikacin
kanamycin
whiB7 3569169 c.-490T>C upstream_gene_variant 0.19 streptomycin
amikacin
kanamycin
lpqB 3624037 c.874A>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624041 p.Glu290Asp missense_variant 0.19 bedaquiline
rifampicin
lpqB 3624050 c.861C>G synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624077 c.834G>A synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624082 c.829A>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624086 c.825C>T synonymous_variant 0.26 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624092 c.817_819delAGGinsCC frameshift_variant&missense_variant 0.26 bedaquiline
rifampicin Uncertain significance
lpqB 3624100 c.811T>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624101 c.810C>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624143 c.768T>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624166 p.Met249Leu missense_variant 0.27 bedaquiline
rifampicin
lpqB 3624167 c.744C>T synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624173 c.738A>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624179 c.732C>G synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624185 c.726C>T synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624194 c.717C>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624200 c.711A>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624204 p.Ser236Asn missense_variant 0.24 bedaquiline
rifampicin
lpqB 3624209 c.702A>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624673 p.Ala80Ser missense_variant 0.27 bedaquiline
rifampicin
lpqB 3624674 c.237C>T synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624680 c.231T>A synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.27 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>C synonymous_variant 0.38 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.38 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.38 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.37 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.39 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625117 c.-207T>G upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.26 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625195 c.-285A>G upstream_gene_variant 0.39 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625206 p.Ser470Ala missense_variant 0.4 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625225 c.-315G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625240 c.-330T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625243 c.-333T>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625279 c.-369C>G upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3625301 p.Ala438Gly missense_variant 0.31 bedaquiline
rifampicin
lpqB 3625513 c.-603G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625518 c.-608T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625525 c.-615G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625549 c.-639G>A upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.43 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.45 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.38 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.39 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.52 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.54 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.57 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626157 p.Ala153Ser missense_variant 0.19 bedaquiline
rifampicin
mtrB 3626158 c.456C>T synonymous_variant 0.19 bedaquiline
rifampicin
mtrB 3626161 c.453C>A synonymous_variant 0.19 bedaquiline
rifampicin
mtrB 3626170 c.444T>C synonymous_variant 0.2 bedaquiline
rifampicin
mtrB 3626687 c.-74G>T upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.21 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.36 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3627343 p.Thr3Ser missense_variant 0.19 bedaquiline
rifampicin
mtrA 3627872 c.-523T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627893 c.-544T>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3627917 c.-568G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3627920 c.-571A>G upstream_gene_variant 0.28 bedaquiline
rifampicin
fbiB 3642560 c.1026T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3642566 c.1032A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3642581 c.1047A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642593 c.1059G>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642609 p.Ser359Cys missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiB 3642614 c.1080C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
rpoA 3877494 p.Glu338Asp missense_variant 0.42 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.43 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.45 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.46 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.58 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.59 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.53 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.53 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.52 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.46 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.46 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.55 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.62 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.62 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.58 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.6 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.62 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.61 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.59 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.53 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.55 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.56 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.53 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.53 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.48 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.39 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.35 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.28 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.27 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.26 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.31 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878094 c.414C>G synonymous_variant 0.32 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.29 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.31 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.29 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.37 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.48 rifampicin
rpoA 3878181 c.327C>T synonymous_variant 0.5 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.51 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.48 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.44 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.45 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.41 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.31 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.23 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.28 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.29 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.29 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.31 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.3 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.33 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.34 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.35 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.4 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.45 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.45 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.44 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.43 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.41 rifampicin
rpoA 3878683 c.-176G>C upstream_gene_variant 0.39 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.5 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.5 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.54 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.57 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.57 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.63 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.63 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.63 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.68 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.66 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.63 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.61 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.62 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.64 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.64 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.58 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.58 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.66 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.67 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.67 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.59 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.59 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.62 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.62 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.61 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.52 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.53 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.53 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.55 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.56 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.5 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.51 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.51 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.51 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.49 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.59 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.58 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.5 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.53 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.5 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.47 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.22 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.21 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.21 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.33 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.28 delamanid
pretomanid
clpC1 4038212 c.2493T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038239 c.2466T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038255 p.Val817Lys missense_variant 0.32 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.32 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.31 pyrazinamide
clpC1 4038275 c.2430A>G synonymous_variant 0.31 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAT frameshift_variant&missense_variant 0.21 pyrazinamide
clpC1 4038320 c.2385G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.31 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.3 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.3 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.3 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.27 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.29 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.33 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.29 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.29 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.28 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.47 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.5 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.4 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.37 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.39 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.39 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.62 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.61 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.56 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.56 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.6 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.56 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.56 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.54 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.56 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.56 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.58 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.54 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.48 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.46 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.45 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.51 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.48 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.51 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.53 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.56 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.58 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.53 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.51 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.52 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.53 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.32 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.22 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.23 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.38 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.41 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.4 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039480 c.1225C>A synonymous_variant 0.45 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.47 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.48 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.57 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.57 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.67 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.66 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.56 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.42 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.49 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.4 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.43 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.52 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.49 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.54 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.54 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.52 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.56 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040237 c.468C>T synonymous_variant 0.26 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.38 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.48 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.48 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.47 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.34 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.21 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.25 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.31 pyrazinamide
clpC1 4040501 c.204C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.27 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.27 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
panD 4043865 c.415_417delGGAinsCG frameshift_variant&missense_variant 0.29 pyrazinamide Uncertain significance
panD 4043872 p.Gly137Val missense_variant 0.3 pyrazinamide Uncertain significance
panD 4043876 p.Leu136Ile missense_variant 0.33 pyrazinamide
panD 4043883 c.399C>T synonymous_variant 0.33 pyrazinamide
panD 4043886 c.396A>G synonymous_variant 0.33 pyrazinamide
panD 4043896 p.Gly129Ala missense_variant 0.31 pyrazinamide
panD 4043903 p.Asn127Asp missense_variant 0.3 pyrazinamide
panD 4043913 c.369T>C synonymous_variant 0.28 pyrazinamide
panD 4043916 c.366A>G synonymous_variant 0.3 pyrazinamide
panD 4044105 c.177G>C synonymous_variant 0.38 pyrazinamide
panD 4044117 c.165G>C synonymous_variant 0.35 pyrazinamide
panD 4044120 c.162A>C synonymous_variant 0.33 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.21 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.27 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.29 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.33 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.38 pyrazinamide
panD 4044758 c.-477C>T upstream_gene_variant 0.4 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.39 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.44 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.48 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.52 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.44 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.42 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.42 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.4 pyrazinamide
panD 4044848 c.-567T>G upstream_gene_variant 0.4 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.31 pyrazinamide
panD 4044860 c.-579C>G upstream_gene_variant 0.31 pyrazinamide
panD 4044872 c.-591C>G upstream_gene_variant 0.26 pyrazinamide
panD 4044986 c.-705C>G upstream_gene_variant 0.21 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.24 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.2 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.2 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.27 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.28 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.3 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.33 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.31 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.26 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.24 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.24 pyrazinamide
panD 4045088 c.-807T>C upstream_gene_variant 0.19 pyrazinamide
glpK 4138622 c.1134C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138646 c.1110G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.41 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.5 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139581 p.Asn59Asp missense_variant 0.38 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Gln missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139611 p.Ile49Val missense_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139651 c.103_105delCACinsGG frameshift_variant&missense_variant 0.56 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139684 c.72C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139687 c.69C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239298 c.-565C>T upstream_gene_variant 0.97 ethambutol Not assoc w R
embC 4240671 p.Thr270Ile missense_variant 0.18 ethambutol Not assoc w R
embC 4240693 c.831T>G synonymous_variant 0.26 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.46 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.45 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.42 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.37 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.37 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.36 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.21 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.18 ethambutol Uncertain significance
embC 4240897 c.1035C>G synonymous_variant 0.2 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.2 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.19 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.19 ethambutol
embC 4241013 p.Met384Thr missense_variant 0.23 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.25 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.3 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.3 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.32 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.33 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.33 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.34 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.45 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.36 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.38 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.47 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.46 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.45 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.44 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.47 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.45 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.36 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embC 4241218 c.1356G>C synonymous_variant 0.33 ethambutol
embC 4241230 c.1368A>G synonymous_variant 0.26 ethambutol
embC 4241233 c.1371G>C synonymous_variant 0.28 ethambutol
embC 4241395 p.Lys511Asn missense_variant 0.2 ethambutol Uncertain significance
embC 4241449 c.1587C>G synonymous_variant 0.36 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.35 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.3 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.31 ethambutol
embC 4241530 c.1668C>A synonymous_variant 0.33 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.36 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.31 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.3 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.31 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.32 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.34 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.34 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.35 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.39 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.43 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.35 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.37 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.31 ethambutol
embC 4241635 c.1773G>C synonymous_variant 0.3 ethambutol
embC 4241713 c.1851G>C synonymous_variant 0.24 ethambutol
embC 4241719 c.1857G>C synonymous_variant 0.29 ethambutol
embC 4241727 p.Phe622Tyr missense_variant 0.39 ethambutol
embC 4241741 c.1879_1881delGTCinsCG frameshift_variant&missense_variant 0.34 ethambutol
embC 4241747 p.Val629Leu missense_variant 0.37 ethambutol
embC 4241750 p.Leu630Val missense_variant 0.35 ethambutol
embC 4241755 c.1893C>G synonymous_variant 0.41 ethambutol
embC 4241770 c.1908T>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embC 4241791 c.1929G>C synonymous_variant 0.48 ethambutol
embC 4241794 c.1932C>G synonymous_variant 0.46 ethambutol
embC 4241797 c.1935C>T synonymous_variant 0.44 ethambutol
embC 4241809 c.1947A>C synonymous_variant 0.38 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242742 c.-491C>G upstream_gene_variant 0.29 ethambutol
embA 4242748 c.-485A>G upstream_gene_variant 0.29 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.29 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.31 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.34 ethambutol
embC 4242791 c.2929_2931delGCAinsTC frameshift_variant&missense_variant 0.31 ethambutol
embA 4242796 c.-437G>C upstream_gene_variant 0.33 ethambutol
embA 4242799 c.-434T>C upstream_gene_variant 0.31 ethambutol
embC 4242803 p.Val981Leu missense_variant 0.68 ethambutol Not assoc w R
embA 4242820 c.-413G>C upstream_gene_variant 0.36 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.35 ethambutol
embA 4242832 c.-401A>C upstream_gene_variant 0.32 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.3 ethambutol
embC 4242841 c.2979C>T synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embA 4242844 c.-389A>G upstream_gene_variant 0.27 ethambutol
embA 4242847 c.-386C>A upstream_gene_variant 0.28 ethambutol
embA 4242859 c.-374C>T upstream_gene_variant 0.26 ethambutol
embA 4242862 c.-371A>G upstream_gene_variant 0.25 ethambutol
embC 4242863 p.Tyr1001Asn missense_variant 0.27 ethambutol
embC 4242883 c.3021C>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embA 4242892 c.-341G>C upstream_gene_variant 0.21 ethambutol
embA 4245053 c.1821G>C synonymous_variant 0.33 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.39 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.49 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.5 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.5 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.51 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.62 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.62 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.58 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.58 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.58 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.6 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.58 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.53 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.58 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.53 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.42 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.43 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
embB 4246184 c.-330A>C upstream_gene_variant 0.21 ethambutol
embB 4246196 c.-318C>G upstream_gene_variant 0.24 ethambutol
embB 4246205 c.-309A>G upstream_gene_variant 0.26 ethambutol
embB 4246211 c.-303T>C upstream_gene_variant 0.27 ethambutol
embB 4246217 c.-297G>A upstream_gene_variant 0.27 ethambutol
embA 4246220 c.2988T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4246223 c.-291C>T upstream_gene_variant 0.29 ethambutol
embA 4246227 p.Ile999Val missense_variant 0.3 ethambutol
embA 4246235 c.3003G>A synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embA 4246242 p.Gln1004Gly missense_variant 0.34 ethambutol
embB 4246250 c.-264G>C upstream_gene_variant 0.34 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.41 ethambutol
embA 4246264 p.His1011Arg missense_variant 0.38 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.32 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.25 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.25 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.27 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.27 ethambutol
embA 4246329 p.Thr1033Leu missense_variant 0.2 ethambutol
embB 4246349 c.-165C>G upstream_gene_variant 0.22 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.2 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.2 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.21 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.21 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.4 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.39 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.46 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.43 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.44 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.4 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.3 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.25 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.3 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.32 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.33 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.33 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.33 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.39 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.41 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.41 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.51 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.48 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.48 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.49 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.46 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.48 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.44 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.47 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.48 ethambutol
embB 4247932 c.1419C>G synonymous_variant 0.37 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.39 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.37 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.35 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.37 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.31 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.25 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.25 ethambutol Uncertain significance
embB 4248035 p.Val508Ile missense_variant 0.35 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.32 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.33 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.33 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.34 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.36 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.38 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.35 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.36 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.35 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.35 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.35 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.41 ethambutol Not assoc w R - Interim
embB 4248199 c.1686A>G synonymous_variant 0.51 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.51 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.51 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.52 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.61 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.5 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.45 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.39 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.33 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.3 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.29 ethambutol
embB 4248361 c.1848A>C synonymous_variant 0.29 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.29 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.34 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.32 ethambutol
embB 4248407 p.Leu632Val missense_variant 0.32 ethambutol
embB 4248410 c.1897_1899delTTCinsCG frameshift_variant&missense_variant 0.31 ethambutol
embB 4248419 p.Leu636Met missense_variant 0.3 ethambutol
embB 4248425 c.1912T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4248430 c.1917T>C synonymous_variant 0.29 ethambutol
embB 4248432 p.Trp640Phe missense_variant 0.27 ethambutol
embB 4248457 c.1944T>C synonymous_variant 0.32 ethambutol
embB 4248472 c.1959T>C synonymous_variant 0.21 ethambutol
embB 4248475 c.1962G>C synonymous_variant 0.2 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.3 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.3 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.3 ethambutol
embB 4249429 c.2916C>T synonymous_variant 0.36 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.35 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.37 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.41 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.29 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.28 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.22 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.23 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.24 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.26 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.23 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.21 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.2 ethambutol
aftB 4267200 p.Trp546Val missense_variant 0.2 ethambutol
aftB 4267214 c.1623A>C synonymous_variant 0.21 ethambutol
aftB 4267244 c.1593T>C synonymous_variant 0.21 ethambutol
aftB 4267256 c.1581C>G synonymous_variant 0.2 ethambutol
aftB 4267262 c.1575T>C synonymous_variant 0.21 ethambutol
aftB 4267266 p.Ala524Gly missense_variant 0.2 ethambutol
aftB 4267268 c.1569T>C synonymous_variant 0.2 ethambutol
aftB 4267274 c.1563G>C synonymous_variant 0.19 ethambutol
aftB 4267574 c.1263G>A synonymous_variant 0.28 ethambutol
aftB 4267580 c.1257G>T synonymous_variant 0.33 ethambutol
aftB 4267604 c.1233C>G synonymous_variant 0.39 ethambutol
aftB 4267607 c.1230G>A synonymous_variant 0.39 ethambutol
aftB 4267622 c.1215G>C synonymous_variant 0.37 ethambutol
aftB 4267625 c.1212T>C synonymous_variant 0.36 ethambutol
aftB 4267628 c.1209C>G synonymous_variant 0.38 ethambutol
aftB 4267634 p.Arg401His missense_variant 0.35 ethambutol
aftB 4268102 c.735C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
aftB 4268117 c.720G>C synonymous_variant 0.38 ethambutol
aftB 4268123 c.712_714delAGTinsGC frameshift_variant&synonymous_variant 0.36 ethambutol Uncertain significance
aftB 4268129 c.708T>G synonymous_variant 0.39 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.41 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.43 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.44 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.43 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.44 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.43 ethambutol Not assoc w R - Interim
aftB 4268182 p.Phe219Leu missense_variant 0.43 ethambutol
aftB 4268183 c.654A>T synonymous_variant 0.43 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 0.42 ethambutol
aftB 4268205 p.Val211Ala missense_variant 0.36 ethambutol
aftB 4268213 c.624T>G synonymous_variant 0.3 ethambutol
aftB 4268225 c.612G>C synonymous_variant 0.3 ethambutol
aftB 4268236 p.Leu201Met missense_variant 0.22 ethambutol
ethA 4328463 c.-990G>C upstream_gene_variant 0.2 ethionamide
ethA 4328467 c.-994G>T upstream_gene_variant 0.2 ethionamide
ethA 4328470 c.-998_-997delAGinsGC upstream_gene_variant 0.19 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin