TB-Profiler result

Run: SRR23961559
Summary

Run ID: SRR23961559

Sample name:

Date: 2024-04-15T10:56:29.158989

Number of reads: 3768453

Percentage reads mapped: 65.87

Median coverage: 19.0

Strain: La1.7;lineage4.2

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.2 Euro-American None 0.06
La1.7 M.bovis None 0.99
La1 M.bovis None 0.83
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Asn399Asp Mutation from literature
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.409_411delGGGinsCA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.421_423delCAGinsGA Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.916_918delTTCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491191 c.409_411delGGGinsCA frameshift_variant&missense_variant 0.38 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491203 c.421_423delCAGinsGA frameshift_variant&missense_variant 0.4 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.57 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303846 c.916_918delTTCinsGG frameshift_variant&missense_variant 0.44 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance Mutation from literature
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
embB 4247448 p.His312Arg missense_variant 0.54 ethambutol Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.29 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
dnaA 741 c.741T>C synonymous_variant 0.61 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.53 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.64 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.67 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.68 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.68 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.67 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.71 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.72 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.72 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.72 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.72 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.72 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.7 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.68 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.69 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.69 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 876 c.876C>G synonymous_variant 0.41 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.63 isoniazid
dnaA 1077 c.1077A>G synonymous_variant 0.33 isoniazid
dnaA 1080 c.1080C>G synonymous_variant 0.38 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.54 isoniazid Not assoc w R - Interim
dnaA 1104 c.1104T>C synonymous_variant 0.55 isoniazid
dnaA 1110 c.1110T>A synonymous_variant 0.5 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.55 isoniazid
dnaA 1119 c.1119G>A synonymous_variant 0.56 isoniazid
dnaA 1134 c.1134G>T synonymous_variant 0.4 isoniazid
dnaA 1137 c.1137C>T synonymous_variant 0.45 isoniazid Not assoc w R - Interim
dnaA 1140 c.1140C>G synonymous_variant 0.4 isoniazid
dnaA 1149 c.1149C>G synonymous_variant 0.53 isoniazid Not assoc w R - Interim
dnaA 1152 c.1152A>G synonymous_variant 0.53 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.54 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.39 isoniazid
dnaA 1164 c.1164A>G synonymous_variant 0.47 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.59 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.62 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.58 isoniazid Not assoc w R - Interim
dnaA 1218 c.1218C>G synonymous_variant 0.36 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.62 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.62 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.58 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.55 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.52 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.48 isoniazid
dnaA 1281 c.1281C>G synonymous_variant 0.46 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.54 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.59 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.59 isoniazid Not assoc w R - Interim
dnaA 1305 c.1305C>T synonymous_variant 0.54 isoniazid
dnaA 1311 c.1311C>T synonymous_variant 0.54 isoniazid Not assoc w R - Interim
dnaA 1317 c.1317A>G synonymous_variant 0.58 isoniazid
dnaA 1338 c.1338T>C synonymous_variant 0.5 isoniazid
dnaA 1365 c.1365C>T synonymous_variant 0.45 isoniazid
gyrB 5267 p.Asp10Asn missense_variant 0.33 levofloxacin
moxifloxacin
gyrB 5282 c.43_45delGCGinsTA frameshift_variant&stop_gained 0.35 levofloxacin Uncertain significance
moxifloxacin
gyrB 5285 c.46_48delTCTinsGG frameshift_variant&missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin
gyrB 5294 c.55_57delATTinsGG frameshift_variant&missense_variant 0.38 levofloxacin Uncertain significance
moxifloxacin
gyrB 5341 c.102T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 5344 c.105C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 5347 c.108G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 5359 c.120C>T synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 5363 c.124_126delTTAinsCG frameshift_variant&missense_variant 0.5 levofloxacin Uncertain significance
moxifloxacin
gyrB 5371 c.132T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 5377 c.138T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6215 p.Ser326Thr missense_variant 0.24 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.48 levofloxacin
moxifloxacin
gyrB 6259 p.Asp340Glu missense_variant 0.46 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.72 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrB 6301 c.1062G>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6313 c.-989C>A upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6346 c.-956C>A upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrB 6352 c.1113C>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6361 c.-941G>A upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6409 c.-893A>G upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrA 6412 c.-890G>A upstream_gene_variant 0.67 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 6418 c.-884C>G upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.68 levofloxacin
moxifloxacin
gyrA 6430 c.-872A>G upstream_gene_variant 0.71 levofloxacin
moxifloxacin
gyrB 6439 c.1200C>G synonymous_variant 0.81 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6440 p.Thr401Ala missense_variant 0.81 levofloxacin
moxifloxacin
gyrA 6448 c.-854G>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6454 c.-848C>G upstream_gene_variant 0.79 levofloxacin
moxifloxacin
gyrA 6457 c.-845T>G upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrA 6469 c.-833T>G upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 6751 c.-551G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.65 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6778 c.-524C>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6784 c.-518C>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.59 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.62 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6832 c.1593C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6856 c.1617T>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6866 c.-436C>T upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrB 6881 c.1642T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7093 c.1854T>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7108 c.-194G>A upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 7124 c.-178_-176delTCGinsAGC upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.61 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>C upstream_gene_variant 0.62 levofloxacin
moxifloxacin
gyrA 7168 c.-134C>G upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.63 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7207 c.-95C>G upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrA 7213 c.-89G>C upstream_gene_variant 0.58 levofloxacin
moxifloxacin
gyrB 7216 c.1977G>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7307 c.6A>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7313 c.12G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7317 c.16T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7324 c.23_24insAGG disruptive_inframe_insertion 0.35 levofloxacin
moxifloxacin
gyrA 7334 c.33G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7335 p.Leu12Val missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 7347 p.Glu16Gln missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 7355 c.54T>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7418 c.117C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7433 c.132G>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7442 c.141G>T synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7587 c.286C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7601 c.300C>G synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 7748 c.447A>G synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7760 c.459C>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7775 c.474C>T synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7778 c.477G>T synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7811 c.510C>T synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7832 c.531G>A synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.63 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.66 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8222 c.921C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8225 c.924T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8228 c.927G>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.6 levofloxacin
moxifloxacin
gyrA 8246 c.945C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.62 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.63 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.66 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.66 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.6 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8477 c.1176C>A synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8481 c.1180C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8628 c.1327C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8684 c.1383G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8690 c.1389C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Gln missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.73 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.74 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.79 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.65 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.68 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8882 c.1581G>A synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.72 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8906 c.1605C>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8918 c.1617C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.7 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.67 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.64 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9026 c.1725G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.45 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9065 c.1764C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9066 c.1765C>A synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.64 levofloxacin
moxifloxacin
gyrA 9128 c.1827C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9147 p.Gly616Ser missense_variant 0.49 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 9179 c.1878C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9208 p.Lys636Arg missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 9217 p.Asp639Ala missense_variant 0.47 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9230 c.1929T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.39 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9266 c.1965C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9268 p.Asn656Ser missense_variant 0.57 levofloxacin
moxifloxacin
gyrA 9276 c.1975C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9287 c.1986G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9290 c.1989G>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9291 c.1990C>T synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 9318 c.2017C>T synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9419 c.2118T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 9421 p.Ile707Thr missense_variant 0.5 levofloxacin
moxifloxacin
gyrA 9429 p.Arg710Tyr missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 9435 c.2134C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9443 c.2142G>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9452 c.2151G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9455 c.2154T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9458 c.2157A>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9482 c.2181G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9485 c.2184A>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9488 c.2187G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9491 c.2190C>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9494 c.2193T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9497 c.2196G>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9500 c.2199A>G synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9503 c.2202T>C synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 9506 c.2205C>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9518 c.2217A>G synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 9527 c.2226A>G synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 9542 c.2241T>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9545 c.2244A>G synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9551 c.2250G>T synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 9560 c.2259C>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9566 c.2265C>T synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9578 c.2277C>T synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9585 c.2284T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
fgd1 491121 c.339A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491127 c.345C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491137 p.Glu119Gln missense_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>T synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fgd1 491220 c.438C>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491241 c.459C>T synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491265 c.483G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491268 c.486C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491277 c.495G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
ccsA 619504 c.-387G>A upstream_gene_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 619507 c.-384A>G upstream_gene_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 619528 c.-363C>G upstream_gene_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356_-354delCAAinsGCC upstream_gene_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 619543 c.-348C>G upstream_gene_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 619564 c.-327C>G upstream_gene_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 619597 c.-294G>C upstream_gene_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>C upstream_gene_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 619630 c.-261C>T upstream_gene_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 619642 c.-249G>C upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.48 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.37 capreomycin
amikacin
kanamycin
Rv0565c 656197 p.Leu425Arg missense_variant 0.55 ethionamide
Rv0565c 656212 p.Arg420His missense_variant 0.6 ethionamide
Rv0565c 656219 p.His418Tyr missense_variant 0.46 ethionamide
Rv0565c 656220 c.1251A>T synonymous_variant 0.46 ethionamide
Rv0565c 656223 c.1248T>C synonymous_variant 0.46 ethionamide Not assoc w R - Interim
Rv0565c 656226 c.1243_1245delGCCinsTT frameshift_variant&missense_variant 0.46 ethionamide Uncertain significance
Rv0565c 656238 p.Ala411Glu missense_variant 0.4 ethionamide
Rv0565c 656243 p.Leu410Met missense_variant 0.4 ethionamide
Rv0565c 656244 c.1227A>C synonymous_variant 0.4 ethionamide
Rv0565c 656265 c.1206G>C synonymous_variant 0.38 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.33 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.33 ethionamide
Rv0565c 656283 c.1188G>C synonymous_variant 0.33 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.35 ethionamide
Rv0565c 656292 c.1179G>A synonymous_variant 0.32 ethionamide
Rv0565c 656298 c.1173G>C synonymous_variant 0.3 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.37 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.37 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.34 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.34 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.36 ethionamide
Rv0565c 657348 c.123A>G synonymous_variant 0.37 ethionamide
Rv0565c 657375 c.96C>T synonymous_variant 0.32 ethionamide
Rv0565c 657381 c.90A>G synonymous_variant 0.32 ethionamide
Rv0565c 657385 p.Ile29Thr missense_variant 0.3 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.41 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.5 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.35 isoniazid
hadA 731690 c.-240_-237delAGACinsCAGATCTTTTCAAGAA upstream_gene_variant 0.44 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.53 isoniazid
hadA 731726 c.-204C>A upstream_gene_variant 0.53 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.66 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.62 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.38 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.38 isoniazid
nusG 734370 c.117A>G synonymous_variant 0.23 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.32 rifampicin
nusG 734403 c.150C>T synonymous_variant 0.58 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.56 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.54 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.56 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.71 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.73 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.43 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.49 rifampicin
nusG 734484 c.231C>T synonymous_variant 0.49 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.4 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.62 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.49 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.53 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.57 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760241 c.435G>C synonymous_variant 0.65 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.8 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.8 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.79 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760356 p.Thr184Ser missense_variant 0.8 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.76 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.75 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.68 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.39 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.51 rifampicin
rpoB 760519 p.Thr238Ser missense_variant 0.56 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.65 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.68 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.56 rifampicin Uncertain significance
rpoB 760571 c.765G>C synonymous_variant 0.32 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.62 rifampicin
rpoB 760607 c.801G>A synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.6 rifampicin
rpoB 760679 c.873A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.58 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.6 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.58 rifampicin
rpoB 760760 c.954C>G synonymous_variant 0.53 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.58 rifampicin
rpoB 760784 c.978G>C synonymous_variant 0.57 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.57 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.65 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.78 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.73 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.69 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.67 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.7 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.75 rifampicin
rpoB 760920 c.1114C>T synonymous_variant 0.75 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.71 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.59 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>T synonymous_variant 0.59 rifampicin
rpoB 760973 c.1167G>C synonymous_variant 0.56 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.24 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.85 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.61 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.58 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>C synonymous_variant 0.32 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.59 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.25 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.55 rifampicin
rpoB 761309 c.1503C>T synonymous_variant 0.55 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.52 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.62 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.48 rifampicin
rpoB 761373 p.Val523His missense_variant 0.48 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.3 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.26 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.68 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.72 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.38 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.48 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.86 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.79 rifampicin
rpoB 761651 c.1845C>T synonymous_variant 0.79 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761660 c.1854G>C synonymous_variant 0.46 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.37 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.42 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.4 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.42 rifampicin
rpoB 761717 c.1911C>G synonymous_variant 0.45 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.26 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.61 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.7 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.29 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.67 rifampicin
rpoB 761753 c.1947C>G synonymous_variant 0.3 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.66 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.65 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.66 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.66 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.61 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.55 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.6 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.52 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.52 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.55 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.55 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.61 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.58 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.56 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.57 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.6 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.58 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.56 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.34 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.49 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.57 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.58 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.62 rifampicin
rpoB 762149 c.2343G>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.57 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.47 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.5 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.47 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.5 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.47 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.48 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.28 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.39 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.49 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.47 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.55 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.38 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.39 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.38 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762957 c.3151C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.64 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.69 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.67 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>C upstream_gene_variant 0.56 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.55 rifampicin
rpoC 763208 c.-162T>C upstream_gene_variant 0.55 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.5 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.46 rifampicin
rpoC 763262 c.-108C>A upstream_gene_variant 0.44 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763284 c.-86C>T upstream_gene_variant 0.34 rifampicin
rpoC 763402 c.33C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.34 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.43 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.49 rifampicin
rpoC 763492 c.123G>T synonymous_variant 0.51 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.59 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.68 rifampicin
rpoC 763639 c.270G>A synonymous_variant 0.66 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763648 c.279C>T synonymous_variant 0.65 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763663 c.294C>G synonymous_variant 0.65 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.7 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.71 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.71 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.67 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.67 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.7 rifampicin
rpoC 763780 c.411C>T synonymous_variant 0.58 rifampicin
rpoC 763786 c.417C>G synonymous_variant 0.57 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.63 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.56 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.48 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.5 rifampicin
rpoC 763853 c.484_486delGTCinsAT frameshift_variant&missense_variant 0.58 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.55 rifampicin
rpoC 763871 p.Gly168Ser missense_variant 0.59 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.62 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.65 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.72 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.73 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.62 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.72 rifampicin
rpoC 763948 c.579G>C synonymous_variant 0.6 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.77 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.77 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.58 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.8 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.79 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.74 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.79 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.78 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.81 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.86 rifampicin
rpoC 764110 c.741C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.85 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Thr missense_variant 0.72 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.78 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764242 c.873C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>A synonymous_variant 0.71 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.8 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.81 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.8 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764320 c.951C>G synonymous_variant 0.63 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.45 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.41 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.42 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.35 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764815 c.1446A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.46 rifampicin Not assoc w R
rpoC 765259 c.1890G>C synonymous_variant 0.27 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.43 rifampicin Uncertain significance
rpoC 765304 c.1935G>A synonymous_variant 0.44 rifampicin
rpoC 765305 c.1936_1938delATCinsCG frameshift_variant&missense_variant 0.43 rifampicin
rpoC 765319 c.1950A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.46 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.44 rifampicin Uncertain significance
rpoC 765346 c.1977C>G synonymous_variant 0.53 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765364 p.Glu665Asp missense_variant 0.5 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.5 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.51 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.51 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.6 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.66 rifampicin
rpoC 765550 c.2181C>T synonymous_variant 0.61 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.63 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.6 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.54 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.55 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.36 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.38 rifampicin Uncertain significance
rpoC 765784 c.2415C>G synonymous_variant 0.52 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.52 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.52 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.59 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.62 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.69 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.55 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.47 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.42 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.4 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.3 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.4 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.48 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.47 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.59 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.51 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.57 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.58 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.57 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.61 rifampicin
rpoC 766621 c.3252G>A synonymous_variant 0.54 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.56 rifampicin
rpoC 766654 c.3285C>G synonymous_variant 0.55 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.64 rifampicin
rpoC 766660 c.3291G>A synonymous_variant 0.55 rifampicin
rpoC 766666 c.3297C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766672 c.3303T>C synonymous_variant 0.64 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.66 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.67 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.7 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.63 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.71 rifampicin
rpoC 766879 c.3510G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.69 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.69 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.71 rifampicin
rpoC 766915 c.3546C>T synonymous_variant 0.44 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.74 rifampicin
rpoC 766934 p.Glu1189Ser missense_variant 0.39 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.79 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.39 rifampicin
rpoC 766978 c.3609C>T synonymous_variant 0.4 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.27 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.27 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.47 rifampicin
rpoC 767038 c.3669G>C synonymous_variant 0.31 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.69 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.57 rifampicin
rpoC 767149 c.3780C>A synonymous_variant 0.54 rifampicin
rpoC 767152 c.3783T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.56 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.76 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpR5 779075 p.Ser29Phe missense_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.44 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.46 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.49 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.5 streptomycin
rpsL 781631 c.72G>C synonymous_variant 0.35 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.59 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.6 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.33 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.6 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.65 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.61 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.33 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.34 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.3 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.29 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.64 streptomycin
rpsL 781757 c.198C>T synonymous_variant 0.34 streptomycin Not assoc w R - Interim
rpsL 781760 c.201T>C synonymous_variant 0.64 streptomycin
rpsL 781769 c.210G>A synonymous_variant 0.39 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.5 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.78 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.28 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.28 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.28 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.55 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.74 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.78 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.59 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.73 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.74 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.63 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.73 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.73 streptomycin Uncertain significance
rplC 800498 c.-311G>A upstream_gene_variant 0.44 linezolid
rplC 800516 c.-293G>T upstream_gene_variant 0.6 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.58 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.46 linezolid
rplC 800543 c.-266C>T upstream_gene_variant 0.46 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.57 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.62 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.63 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.67 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.53 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.5 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.62 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.55 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.53 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.47 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.46 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.44 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.41 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.36 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.38 linezolid
Rv1129c 1253088 p.Glu483Lys missense_variant 1.0 moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303674 c.744C>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303689 c.759T>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303740 c.810C>A synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.5 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304511 c.1581C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304517 c.1587C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305279 p.His783Gln missense_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
sigE 1364763 c.351T>C synonymous_variant 0.52 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.46 pyrazinamide
sigE 1364772 c.360G>C synonymous_variant 0.45 pyrazinamide
sigE 1364805 c.393C>G synonymous_variant 0.57 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.59 pyrazinamide
sigE 1364814 c.402C>G synonymous_variant 0.59 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.65 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.61 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.61 pyrazinamide
sigE 1364859 c.447C>G synonymous_variant 0.58 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.61 pyrazinamide
sigE 1364868 c.456T>G synonymous_variant 0.61 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.59 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.59 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.63 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.67 pyrazinamide
sigE 1364922 c.510G>A synonymous_variant 0.67 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.67 pyrazinamide
sigE 1364950 c.538_540delGCAinsTG frameshift_variant&stop_gained 0.56 pyrazinamide Uncertain significance
sigE 1364958 c.546G>C synonymous_variant 0.54 pyrazinamide
sigE 1364961 c.549A>G synonymous_variant 0.52 pyrazinamide
sigE 1364964 c.552T>G synonymous_variant 0.5 pyrazinamide
sigE 1364967 c.555C>T synonymous_variant 0.48 pyrazinamide
sigE 1364976 c.564T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.46 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.46 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.46 pyrazinamide
sigE 1364994 c.582G>A synonymous_variant 0.5 pyrazinamide
sigE 1365012 c.600G>C synonymous_variant 0.46 pyrazinamide
sigE 1365015 c.603G>C synonymous_variant 0.46 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.48 pyrazinamide
sigE 1365033 c.621G>A synonymous_variant 0.45 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.41 pyrazinamide
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
atpE 1460831 c.-214T>C upstream_gene_variant 0.38 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.38 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.37 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.37 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.39 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.46 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.38 bedaquiline
atpE 1460897 c.-148A>C upstream_gene_variant 0.33 bedaquiline
atpE 1460900 c.-145T>C upstream_gene_variant 0.32 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>C non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTT non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.7 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.57 capreomycin
linezolid Uncertain significance
rrl 1475606 n.1949T>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.79 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.76 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.55 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
inhA 1673535 c.-667A>C upstream_gene_variant 0.45 ethionamide
isoniazid
inhA 1673547 c.-655T>C upstream_gene_variant 0.5 ethionamide
isoniazid
inhA 1673577 c.-625C>T upstream_gene_variant 0.69 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.69 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>G upstream_gene_variant 0.69 ethionamide
isoniazid
inhA 1673592 c.-610G>A upstream_gene_variant 0.69 ethionamide
isoniazid
inhA 1673595 c.-607A>C upstream_gene_variant 0.69 ethionamide
isoniazid
fabG1 1673596 p.Lys53Glu missense_variant 0.69 ethionamide
isoniazid
inhA 1673601 c.-601G>C upstream_gene_variant 0.64 ethionamide
isoniazid
inhA 1673604 c.-598G>C upstream_gene_variant 0.64 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.64 ethionamide
isoniazid
fabG1 1673609 p.Gly57Ala missense_variant 0.61 ethionamide
isoniazid
inhA 1673616 c.-586A>G upstream_gene_variant 0.65 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.7 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.68 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.64 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.69 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.69 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.7 ethionamide
isoniazid
inhA 1673712 c.-490A>G upstream_gene_variant 0.67 ethionamide
isoniazid
inhA 1673724 c.-478A>G upstream_gene_variant 0.64 ethionamide
isoniazid
inhA 1673730 c.-472C>G upstream_gene_variant 0.66 ethionamide
isoniazid
inhA 1673742 c.-460C>G upstream_gene_variant 0.68 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.69 ethionamide
isoniazid
inhA 1673784 c.-418G>C upstream_gene_variant 0.67 ethionamide
isoniazid
inhA 1673799 c.-403T>C upstream_gene_variant 0.64 ethionamide
isoniazid
inhA 1673802 c.-400A>G upstream_gene_variant 0.65 ethionamide
isoniazid
inhA 1673826 c.-376C>A upstream_gene_variant 0.66 ethionamide
isoniazid
inhA 1673838 c.-364T>C upstream_gene_variant 0.68 ethionamide
isoniazid
inhA 1673847 c.-355A>C upstream_gene_variant 0.71 ethionamide
isoniazid
inhA 1673853 c.-349A>C upstream_gene_variant 0.73 ethionamide
isoniazid
inhA 1673877 c.-325C>T upstream_gene_variant 0.72 ethionamide
isoniazid
inhA 1673895 c.-307C>T upstream_gene_variant 0.71 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.7 ethionamide
isoniazid
inhA 1673916 c.-286A>G upstream_gene_variant 0.74 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.78 ethionamide
isoniazid
inhA 1673946 c.-256C>G upstream_gene_variant 0.77 ethionamide
isoniazid
fabG1 1673960 p.Ala174Val missense_variant 0.78 ethionamide
isoniazid
inhA 1673988 c.-214G>C upstream_gene_variant 0.76 ethionamide
isoniazid
inhA 1674006 c.-196T>C upstream_gene_variant 0.72 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.72 ethionamide
isoniazid
inhA 1674033 c.-169T>C upstream_gene_variant 0.73 ethionamide
isoniazid
fabG1 1674037 p.Gln200Glu missense_variant 0.74 ethionamide
isoniazid
inhA 1674042 c.-160G>C upstream_gene_variant 0.75 ethionamide
isoniazid Uncertain significance
inhA 1674045 c.-157G>A upstream_gene_variant 0.75 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.75 ethionamide
isoniazid
inhA 1674060 c.-142A>C upstream_gene_variant 0.74 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.7 ethionamide
isoniazid
inhA 1674111 c.-91G>C upstream_gene_variant 0.66 ethionamide
isoniazid
inhA 1674114 c.-88T>G upstream_gene_variant 0.65 ethionamide
isoniazid
inhA 1674129 c.-73C>T upstream_gene_variant 0.62 ethionamide
isoniazid
inhA 1674132 c.-70T>C upstream_gene_variant 0.64 ethionamide
isoniazid
inhA 1674141 c.-61T>C upstream_gene_variant 0.61 ethionamide
isoniazid
inhA 1674171 c.-31T>C upstream_gene_variant 0.5 ethionamide
isoniazid
inhA 1674183 c.-19_-18insCTTCATCCAC upstream_gene_variant 0.39 ethionamide
isoniazid
inhA 1674189 c.-13C>G upstream_gene_variant 0.39 ethionamide
isoniazid
inhA 1674191 c.-11C>A upstream_gene_variant 0.39 ethionamide
isoniazid Uncertain significance
inhA 1674192 c.-10_-9insTT upstream_gene_variant 0.41 ethionamide
isoniazid
inhA 1674199 c.-3C>G upstream_gene_variant 0.41 ethionamide
isoniazid Uncertain significance
inhA 1674205 p.Thr2Ala missense_variant 0.44 ethionamide
isoniazid Uncertain significance
inhA 1674216 c.15G>C synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674219 p.Asp6Glu missense_variant 0.44 ethionamide
isoniazid
inhA 1674231 c.30T>C synonymous_variant 0.47 ethionamide
isoniazid
inhA 1674235 c.34_36delGTTinsAC frameshift_variant&missense_variant 0.47 ethionamide
isoniazid
inhA 1674238 c.37_38delAGinsTC synonymous_variant 0.47 ethionamide
isoniazid
inhA 1674243 c.42A>G synonymous_variant 0.47 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.37 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.56 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.62 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.58 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.54 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.78 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.78 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.72 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.59 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.86 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.81 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.6 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.66 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.64 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.77 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.67 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.81 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.72 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.86 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.88 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.89 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.88 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.88 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.87 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.76 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.75 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.75 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.75 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.74 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.4 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.49 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.79 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.78 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.78 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.78 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.79 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.79 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.74 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.77 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.75 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.74 pyrazinamide
rpsA 1834282 c.741C>T synonymous_variant 0.6 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.65 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.7 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.59 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.72 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.77 pyrazinamide
rpsA 1834462 c.921C>T synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
rpsA 1834468 c.927A>G synonymous_variant 0.82 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.83 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.56 pyrazinamide
rpsA 1834528 c.987T>G synonymous_variant 0.63 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.66 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.61 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.66 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.78 pyrazinamide
rpsA 1834723 c.1182G>A synonymous_variant 0.71 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.77 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.72 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.59 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.53 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 0.85 pyrazinamide Uncertain significance
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
ndh 2102317 c.726A>G synonymous_variant 0.44 ethionamide
delamanid
isoniazid
ndh 2102328 p.Leu239Met missense_variant 0.44 ethionamide
delamanid
isoniazid
ndh 2102334 p.Gln237Glu missense_variant 0.44 ethionamide
delamanid
isoniazid
ndh 2102337 c.706T>C synonymous_variant 0.47 ethionamide Not assoc w R - Interim
delamanid
isoniazid
ndh 2102344 c.699T>G synonymous_variant 0.43 ethionamide
delamanid
isoniazid
ndh 2102347 c.696G>C synonymous_variant 0.47 ethionamide
delamanid
isoniazid
ndh 2102350 c.693G>C synonymous_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2103173 c.-132delG upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2155632 c.480A>C synonymous_variant 0.46 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.42 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.43 isoniazid Uncertain significance
katG 2155661 p.Val151Ile missense_variant 0.39 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.47 isoniazid
katG 2155696 p.Ala139Val missense_variant 0.44 isoniazid
katG 2155698 c.414C>T synonymous_variant 0.46 isoniazid Not assoc w R - Interim
katG 2155716 c.396T>C synonymous_variant 0.54 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.5 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.5 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.54 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.54 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.54 isoniazid
katG 2155767 c.345C>T synonymous_variant 0.39 isoniazid
katG 2155770 c.342C>T synonymous_variant 0.34 isoniazid
katG 2155782 c.330C>G synonymous_variant 0.3 isoniazid
katG 2155785 c.327T>C synonymous_variant 0.33 isoniazid
katG 2155794 p.Ala106Ser missense_variant 0.32 isoniazid
katG 2156025 c.87C>A synonymous_variant 0.9 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168319 p.Thr765Ile missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>C upstream_gene_variant 0.57 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.53 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.51 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 0.52 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.5 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.25 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.31 isoniazid
kasA 2518666 c.552G>A synonymous_variant 0.31 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.54 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.61 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.52 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.52 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.55 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.59 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.61 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.56 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.61 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.77 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.69 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.67 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.67 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.69 isoniazid
kasA 2518796 c.682C>A synonymous_variant 0.51 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.71 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.47 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.62 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.58 isoniazid
kasA 2518867 c.753G>A synonymous_variant 0.57 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.55 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.36 isoniazid
kasA 2518891 c.777C>G synonymous_variant 0.33 isoniazid
kasA 2518892 p.Lys260Gln missense_variant 0.33 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.32 isoniazid
kasA 2518907 c.793T>C synonymous_variant 0.38 isoniazid
kasA 2519095 c.981C>G synonymous_variant 0.41 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.4 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.4 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.43 isoniazid
kasA 2519128 c.1014G>A synonymous_variant 0.5 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.5 isoniazid
kasA 2519146 c.1032C>A synonymous_variant 0.52 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.45 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.48 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.5 isoniazid
kasA 2519196 p.Thr361Ser missense_variant 0.48 isoniazid
kasA 2519206 c.1092C>T synonymous_variant 0.49 isoniazid
kasA 2519221 c.1107G>C synonymous_variant 0.45 isoniazid
kasA 2519230 c.1116C>T synonymous_variant 0.45 isoniazid
kasA 2519236 c.1122G>A synonymous_variant 0.39 isoniazid
kasA 2519239 c.1125A>C synonymous_variant 0.39 isoniazid
folC 2747293 c.306G>A synonymous_variant 0.44 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.47 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.48 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.52 para-aminosalicylic_acid
folC 2747326 c.273G>A synonymous_variant 0.45 para-aminosalicylic_acid
folC 2747334 c.265C>T synonymous_variant 0.47 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.63 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.68 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.65 para-aminosalicylic_acid
folC 2747362 c.237G>A synonymous_variant 0.53 para-aminosalicylic_acid
folC 2747407 c.192T>C synonymous_variant 0.59 para-aminosalicylic_acid
folC 2747442 c.157T>C synonymous_variant 0.58 para-aminosalicylic_acid
Rv2477c 2782441 c.1602G>A synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 c.1590C>T synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.74 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782501 c.1542T>C synonymous_variant 0.77 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782510 c.1531_1533delGCGinsTC frameshift_variant&missense_variant 0.76 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782528 c.1515G>C synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>C synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.68 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782576 c.1467C>G synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782582 c.1461C>T synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782587 p.Leu486Val missense_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782594 c.1449T>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782606 c.1435_1437delGGTinsAC frameshift_variant&missense_variant 0.44 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782927 c.1116A>G synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783015 p.Ser343Thr missense_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.59 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.72 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.79 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.76 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.74 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783083 c.960G>C synonymous_variant 0.34 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783086 p.Asn319Ser missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.69 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.71 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783101 c.942G>C synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783244 p.Thr267Ala missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783290 c.753G>A synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783299 c.744A>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783338 c.705C>T synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 c.544_546delTTGinsCC frameshift_variant&missense_variant 0.35 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783502 c.541T>C synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.52 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783523 c.520C>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.52 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783575 c.468G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783695 c.348C>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783767 c.276C>T synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.6 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783806 c.237G>T synonymous_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783837 p.Thr69Ser missense_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783847 p.Thr66Ala missense_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783851 c.192G>C synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.68 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>A synonymous_variant 0.71 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783914 c.129T>C synonymous_variant 0.79 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>T synonymous_variant 0.77 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783935 c.108C>A synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.67 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.66 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.57 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2681 2997325 p.Ala196Val missense_variant 1.0 capreomycin Uncertain significance
Rv2752c 3065142 c.1050A>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067652 c.294T>C synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067679 p.Cys89Leu missense_variant 0.45 para-aminosalicylic_acid
thyX 3067682 c.264G>C synonymous_variant 0.45 para-aminosalicylic_acid
thyX 3067685 c.261A>T synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067718 c.228C>A synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.66 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.68 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.65 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.67 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067784 c.162C>A synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.69 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.69 para-aminosalicylic_acid
thyX 3067808 c.138C>T synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067811 c.135G>A synonymous_variant 0.68 para-aminosalicylic_acid
thyX 3067850 c.96A>T synonymous_variant 0.67 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.63 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.58 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.43 para-aminosalicylic_acid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3449381 p.Trp293* stop_gained 1.0 ethionamide Uncertain significance
lpqB 3624350 c.561G>T synonymous_variant 0.75 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624359 c.552C>T synonymous_variant 0.39 bedaquiline
rifampicin
lpqB 3624377 c.534C>G synonymous_variant 0.54 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624383 c.528C>T synonymous_variant 0.54 bedaquiline
rifampicin
lpqB 3624392 c.519C>T synonymous_variant 0.48 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624404 c.507G>C synonymous_variant 0.46 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.45 bedaquiline
rifampicin
lpqB 3624416 c.495G>A synonymous_variant 0.46 bedaquiline
rifampicin
lpqB 3624422 c.489G>C synonymous_variant 0.48 bedaquiline
rifampicin
lpqB 3624425 p.Glu162Ala missense_variant 0.48 bedaquiline
rifampicin
lpqB 3624428 c.483A>G synonymous_variant 0.48 bedaquiline
rifampicin
lpqB 3624431 c.480C>T synonymous_variant 0.48 bedaquiline
rifampicin
lpqB 3624452 c.459T>C synonymous_variant 0.57 bedaquiline
rifampicin
lpqB 3624464 c.445_447delCTAinsTG frameshift_variant&synonymous_variant 0.52 bedaquiline
rifampicin Uncertain significance
lpqB 3624470 c.441T>C synonymous_variant 0.46 bedaquiline
rifampicin
lpqB 3624476 c.435C>T synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624482 c.429T>C synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624485 p.Asp142Gly missense_variant 0.4 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624491 c.420G>C synonymous_variant 0.36 bedaquiline
rifampicin
lpqB 3624593 c.318G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624710 c.201G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625117 c.-207T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 0.42 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625138 c.-228C>G upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625141 c.-231T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.43 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.36 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625230 c.-320C>T upstream_gene_variant 0.39 bedaquiline
rifampicin
lpqB 3625240 c.-330T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625243 c.-333T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
lpqB 3625252 c.-342G>A upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625255 c.-345T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625308 c.-398C>A upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3625313 p.Arg434Lys missense_variant 0.29 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.34 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.47 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.49 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.54 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.59 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.61 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625648 c.-738T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.6 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.6 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.67 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.67 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.63 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.58 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.61 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3625747 c.867G>C synonymous_variant 0.58 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626704 c.-91C>T upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626735 c.-122C>T upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.56 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.58 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626912 c.-299T>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3627023 c.-410C>G upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.58 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.57 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.58 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.54 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627104 c.244_246delCTCinsTG frameshift_variant&synonymous_variant 0.53 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627125 c.-512C>T upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.55 bedaquiline
rifampicin
fbiB 3642478 p.Asp315Ala missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
rpoA 3877482 c.1026C>G synonymous_variant 0.52 rifampicin
rpoA 3877494 p.Glu338Asp missense_variant 0.61 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.66 rifampicin
rpoA 3877506 c.1002C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3877515 c.993G>C synonymous_variant 0.68 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.59 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877571 p.Pro313Ala missense_variant 0.47 rifampicin
rpoA 3877572 c.936G>C synonymous_variant 0.47 rifampicin
rpoA 3877575 c.933C>T synonymous_variant 0.48 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.78 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.78 rifampicin
rpoA 3877677 p.Ala277Cys missense_variant 0.46 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877710 c.798C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.35 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.46 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>A synonymous_variant 0.35 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877803 c.705G>T synonymous_variant 0.37 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.53 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.47 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Asn missense_variant 0.28 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.43 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878007 c.501C>A synonymous_variant 0.42 rifampicin
rpoA 3878010 c.498C>G synonymous_variant 0.5 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.5 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.47 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.48 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.47 rifampicin
rpoA 3878064 c.444G>C synonymous_variant 0.38 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.46 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.46 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.4 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.51 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.49 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.58 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.47 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.5 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.57 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.53 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.56 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.61 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.65 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.76 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.63 rifampicin
rpoA 3878262 c.244_246delAGCinsGT frameshift_variant&synonymous_variant 0.59 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.64 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 0.64 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.57 rifampicin
rpoA 3878361 c.147G>C synonymous_variant 0.46 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.46 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.46 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.43 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.35 rifampicin
rpoA 3878388 c.118_120delCGCinsAG frameshift_variant&missense_variant 0.37 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.37 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.37 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.54 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.57 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.57 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.57 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.56 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.59 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.59 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.57 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.35 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.33 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.33 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.33 rifampicin
ddn 3986648 c.-196C>G upstream_gene_variant 0.59 delamanid
pretomanid
clpC1 4038302 c.2403C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAC frameshift_variant&missense_variant 0.66 pyrazinamide
clpC1 4038329 p.Glu792Asp missense_variant 0.54 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.6 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.7 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.7 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.72 pyrazinamide
clpC1 4038374 c.2331C>T synonymous_variant 0.55 pyrazinamide
clpC1 4038383 c.2322G>A synonymous_variant 0.53 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.67 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.66 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.7 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038410 c.2295C>T synonymous_variant 0.55 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.71 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.7 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.52 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.63 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.55 pyrazinamide
clpC1 4038474 p.Ser744Thr missense_variant 0.46 pyrazinamide
clpC1 4038485 p.Gly740Lys missense_variant 0.27 pyrazinamide
clpC1 4038488 p.Ala739Gly missense_variant 0.23 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038498 p.Ser736Asp missense_variant 0.26 pyrazinamide
clpC1 4038519 p.Arg729Lys missense_variant 0.54 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.61 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4038541 c.2164C>T synonymous_variant 0.27 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.74 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.82 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.84 pyrazinamide
clpC1 4038644 p.Glu687Asp missense_variant 0.34 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.51 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.84 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.84 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.83 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.85 pyrazinamide
clpC1 4038674 c.2031C>G synonymous_variant 0.32 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.87 pyrazinamide Not assoc w R - Interim
clpC1 4038692 c.2013C>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.87 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.87 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.87 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.86 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.86 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.84 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.82 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.56 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.77 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.6 pyrazinamide
clpC1 4038848 c.1857C>T synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
clpC1 4038860 c.1845G>T synonymous_variant 0.6 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.58 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.76 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.74 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.74 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.72 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.71 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.7 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.73 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.74 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.61 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.68 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.69 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.69 pyrazinamide
clpC1 4039128 p.Lys526Arg missense_variant 0.58 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.63 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.69 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.7 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.71 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>G synonymous_variant 0.74 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.7 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.72 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.6 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.57 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.53 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.51 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.47 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.49 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.55 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.56 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039412 c.1293T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.55 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039439 c.1266C>T synonymous_variant 0.56 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.58 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.64 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.73 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.71 pyrazinamide
clpC1 4039913 c.792C>T synonymous_variant 0.64 pyrazinamide
clpC1 4039925 c.780C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.47 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.54 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.6 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.63 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.61 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.75 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.79 pyrazinamide
clpC1 4040126 c.579C>T synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4040147 c.558A>G synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.7 pyrazinamide
clpC1 4040195 c.510G>C synonymous_variant 0.6 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.6 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.57 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.5 pyrazinamide
clpC1 4040219 c.486C>G synonymous_variant 0.5 pyrazinamide
clpC1 4040222 c.483G>A synonymous_variant 0.5 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.48 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.5 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.52 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.57 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.57 pyrazinamide
clpC1 4040255 c.450C>G synonymous_variant 0.5 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040315 c.390G>A synonymous_variant 0.4 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.82 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.82 pyrazinamide
clpC1 4040348 c.357G>T synonymous_variant 0.45 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.81 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.86 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.79 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.71 pyrazinamide
clpC1 4040411 c.294T>G synonymous_variant 0.69 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.78 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.76 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.54 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.72 pyrazinamide Not assoc w R - Interim
clpC1 4040462 c.243C>G synonymous_variant 0.66 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.69 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>G synonymous_variant 0.65 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.51 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.64 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>T synonymous_variant 0.23 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.63 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.47 pyrazinamide
clpC1 4040567 c.138C>G synonymous_variant 0.42 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4245737 c.-777A>C upstream_gene_variant 0.44 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.44 ethambutol
embA 4245785 c.2553G>C synonymous_variant 0.47 ethambutol Not assoc w R - Interim
embB 4245797 c.-717C>G upstream_gene_variant 0.47 ethambutol
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247371 c.858C>G synonymous_variant 0.43 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.41 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.48 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.46 ethambutol
embB 4247437 c.924A>C synonymous_variant 0.52 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.54 ethambutol
embB 4247467 c.954C>T synonymous_variant 0.52 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.54 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.56 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.58 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.57 ethambutol
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247716 c.1203C>T synonymous_variant 0.3 ethambutol
embB 4247725 c.1212G>C synonymous_variant 0.3 ethambutol
embB 4247729 p.Gly406Pro missense_variant 0.27 ethambutol
embB 4247743 c.1230C>G synonymous_variant 0.38 ethambutol
embB 4247746 c.1233C>T synonymous_variant 0.4 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.41 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.5 ethambutol
embB 4247792 c.1279C>A synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embB 4247797 c.1284C>G synonymous_variant 0.56 ethambutol
embB 4247800 c.1287A>G synonymous_variant 0.48 ethambutol Not assoc w R - Interim
embB 4247803 c.1290G>C synonymous_variant 0.55 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.56 ethambutol
embB 4247821 c.1308T>C synonymous_variant 0.56 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.48 ethambutol Not assoc w R - Interim
embB 4247881 c.1368G>C synonymous_variant 0.56 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4247899 p.Met462Ile missense_variant 0.51 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.47 ethambutol
embB 4248025 c.1512A>G synonymous_variant 0.38 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.42 ethambutol
embB 4248040 c.1527C>A synonymous_variant 0.38 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.38 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.38 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.39 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.44 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.46 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.43 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.39 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.32 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.33 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.33 ethambutol
embB 4248149 p.Thr546Ala missense_variant 0.36 ethambutol Uncertain significance
embB 4248157 c.1644A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4248161 c.1648C>T synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4248169 c.1656C>G synonymous_variant 0.34 ethambutol
embB 4248172 c.1659G>C synonymous_variant 0.25 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.38 ethambutol
embB 4248206 c.1693_1695delAGCinsGA frameshift_variant&missense_variant 0.39 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.32 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.47 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.52 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.55 ethambutol
embB 4248322 c.1809G>T synonymous_variant 0.53 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.37 ethambutol
embB 4249465 c.2952G>A synonymous_variant 0.48 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.52 ethambutol
embB 4249483 c.2970C>T synonymous_variant 0.47 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.47 ethambutol
embB 4249487 c.2974T>C synonymous_variant 0.47 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.47 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.42 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.42 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.42 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.43 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.43 ethambutol
embB 4249548 p.Phe1012Tyr missense_variant 0.43 ethambutol
embB 4249552 c.3039C>G synonymous_variant 0.44 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.46 ethambutol
embB 4249568 c.3055_3057delTCGinsAC frameshift_variant&missense_variant 0.41 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.42 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.47 ethambutol
embB 4249594 c.3081G>C synonymous_variant 0.46 ethambutol
embB 4249600 c.3087A>G synonymous_variant 0.38 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R