TB-Profiler result

Run: SRR20970043
Summary

Run ID: SRR20970043

Sample name:

Date: 2024-03-26T12:33:41.413725

Number of reads: 1767962

Percentage reads mapped: 19.22

Median coverage: 60.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.5 rifampicin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 609 c.609C>G synonymous_variant 0.18 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.29 isoniazid
dnaA 633 c.633T>G synonymous_variant 0.33 isoniazid
dnaA 660 c.660G>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.41 isoniazid
dnaA 666 c.666C>G synonymous_variant 0.4 isoniazid
dnaA 675 c.675C>G synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>T synonymous_variant 0.39 isoniazid
dnaA 682 c.682_684delTTGinsCC frameshift_variant&missense_variant 0.39 isoniazid Uncertain significance
dnaA 693 c.693A>C synonymous_variant 0.39 isoniazid
dnaA 705 c.705A>G synonymous_variant 0.45 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.47 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.47 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 747 c.747G>T synonymous_variant 0.43 isoniazid
dnaA 748 c.748_750delCTCinsTG frameshift_variant&missense_variant 0.42 isoniazid Uncertain significance
dnaA 763 p.Lys255Arg missense_variant 0.41 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.41 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.37 isoniazid Uncertain significance
dnaA 801 c.801G>T synonymous_variant 0.37 isoniazid
dnaA 804 c.804G>C synonymous_variant 0.37 isoniazid
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.37 isoniazid Uncertain significance
dnaA 822 c.822A>G synonymous_variant 0.4 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 837 c.837A>G synonymous_variant 0.4 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.38 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.34 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.33 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 877 c.877T>C synonymous_variant 0.33 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.31 isoniazid
dnaA 888 c.888C>G synonymous_variant 0.31 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.3 isoniazid
dnaA 903 c.903C>G synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 909 c.909A>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.21 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.15 isoniazid
gyrB 6664 c.1425C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6673 c.-629A>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.19 levofloxacin Uncertain significance
moxifloxacin
gyrA 6739 c.-563C>T upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6754 c.-548C>T upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.31 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6838 c.-464C>T upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6872 c.1633_1635delTTGinsCT frameshift_variant&synonymous_variant 0.24 levofloxacin Uncertain significance
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6889 c.-413G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6898 c.-404G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6985 c.-317C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6988 c.-314C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7010 p.Leu591Met missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7015 c.-287G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7024 c.-278G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.36 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7100 c.1861T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7123 c.-179C>G upstream_gene_variant 0.45 levofloxacin
moxifloxacin
gyrB 7126 c.1887G>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7129 c.-173T>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7135 c.-167G>A upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>A upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7189 c.-113C>T upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 7198 c.1959C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 7210 p.Asp657Glu missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 7213 c.-89G>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7216 c.1977G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7225 c.-77T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7234 c.-68C>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7499 c.198G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7511 c.210C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7760 c.459C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7778 c.477G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7781 c.480G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7782 p.Gln161Met missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7797 c.496_498delCTAinsTG frameshift_variant&stop_gained 0.14 levofloxacin
moxifloxacin
gyrA 7802 c.501C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7811 c.510C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7814 c.513C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8580 p.Ile427Val missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8603 c.1302A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8609 c.1308G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8649 p.Arg450Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8666 c.1365G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8799 p.Ala500Ser missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8817 p.Ser506Ala missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8829 c.1528_1530delTTGinsCC frameshift_variant&missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8840 c.1539C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8846 c.1545C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Lys missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8978 c.1677C>T synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8993 c.1692C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9026 c.1725G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9063 p.Ser588Ala missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491034 c.252C>G synonymous_variant 0.97 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 1.0 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
nusG 734445 c.192C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734452 c.199_201delGAAinsCG frameshift_variant&missense_variant 0.27 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>A synonymous_variant 0.31 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734493 c.240C>T synonymous_variant 0.39 rifampicin
nusG 734497 c.244_246delGTGinsAC frameshift_variant&missense_variant 0.39 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734535 c.282C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734565 c.312G>A synonymous_variant 0.33 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734586 c.333G>A synonymous_variant 0.2 rifampicin
nusG 734595 p.Asp114Glu missense_variant 0.15 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.15 rifampicin
nusG 734600 p.Thr116Asn missense_variant 0.15 rifampicin Uncertain significance
nusG 734607 p.Asp118Glu missense_variant 0.15 rifampicin
nusG 734615 p.Ala121Gly missense_variant 0.12 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.12 rifampicin Uncertain significance
nusG 734807 p.Tyr185Phe missense_variant 0.18 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.21 rifampicin
nusG 734834 p.Met194Thr missense_variant 0.21 rifampicin Uncertain significance
nusG 734841 c.588G>T synonymous_variant 0.21 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.21 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.21 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.2 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.2 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.21 rifampicin
nusG 734864 p.Thr204Ser missense_variant 0.21 rifampicin
nusG 734893 p.Lys214Arg missense_variant 0.19 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.19 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760110 c.304_306delTCTinsAGC synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760118 c.312T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.37 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760274 p.Glu156Asp missense_variant 0.4 rifampicin Uncertain significance
rpoB 760276 p.Lys157Met missense_variant 0.4 rifampicin Uncertain significance
rpoB 760283 c.477G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.28 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.38 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.41 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.43 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.44 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.45 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.51 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760499 c.693G>A synonymous_variant 0.47 rifampicin
rpoB 760502 c.696C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.44 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760553 c.747C>G synonymous_variant 0.34 rifampicin
rpoB 760561 c.757_758delCG frameshift_variant 0.27 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.28 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.28 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.3 rifampicin
rpoB 760588 p.Thr261Ile missense_variant 0.33 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.33 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.33 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.33 rifampicin
rpoB 760608 c.802C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760668 c.862_864delACGinsGC frameshift_variant&missense_variant 0.38 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760703 c.897C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.28 rifampicin
rpoB 760727 c.921C>G synonymous_variant 0.23 rifampicin
rpoB 760730 c.924T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760736 c.930C>G synonymous_variant 0.23 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.19 rifampicin
rpoB 760799 c.993C>T synonymous_variant 0.24 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.28 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.37 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.38 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760858 p.Val351Ala missense_variant 0.44 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760886 p.Glu360Asp missense_variant 0.47 rifampicin Uncertain significance
rpoB 760887 p.Thr361Val missense_variant 0.47 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760928 c.1122G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.45 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760979 c.1173G>A synonymous_variant 0.41 rifampicin
rpoB 760982 c.1176G>T synonymous_variant 0.39 rifampicin
rpoB 760985 c.1179G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.4 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.5 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.5 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAC frameshift_variant&missense_variant 0.48 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.46 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761231 c.1425C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>T synonymous_variant 0.35 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761277 p.Ile491Val missense_variant 0.59 rifampicin Uncertain significance
rpoB 761297 c.1491C>T synonymous_variant 0.4 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761339 c.1533C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.35 rifampicin
rpoB 761346 p.Val514Ser missense_variant 0.33 rifampicin
rpoB 761354 c.1548C>A synonymous_variant 0.35 rifampicin
rpoB 761357 c.1551G>T synonymous_variant 0.35 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.35 rifampicin
rpoB 761373 p.Val523His missense_variant 0.35 rifampicin
rpoB 761387 c.1581C>T synonymous_variant 0.34 rifampicin
rpoB 761393 c.1587G>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761414 c.1608A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.23 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.39 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.48 rifampicin
rpoB 761657 c.1851C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.39 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.38 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.33 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.33 rifampicin
rpoB 761693 c.1887G>C synonymous_variant 0.33 rifampicin
rpoB 761705 c.1899C>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761724 p.Glu640Lys missense_variant 0.12 rifampicin
rpoB 761727 p.Ser641Gly missense_variant 0.27 rifampicin
rpoB 761741 c.1935G>A synonymous_variant 0.27 rifampicin
rpoB 761750 c.1944G>T synonymous_variant 0.25 rifampicin
rpoB 761760 p.Ile652Val missense_variant 0.17 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.12 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.16 rifampicin
rpoB 761863 p.Ala686Glu missense_variant 0.28 rifampicin
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 0.28 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.31 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.49 rifampicin
rpoB 761892 p.Ile696Val missense_variant 0.51 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.6 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.6 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.6 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.6 rifampicin
rpoB 761924 c.2118G>A synonymous_variant 0.6 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.6 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.62 rifampicin
rpoB 761936 c.2130C>T synonymous_variant 0.64 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>A synonymous_variant 0.7 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.7 rifampicin Uncertain significance
rpoB 761969 c.2163G>A synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.65 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.66 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.65 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.66 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.68 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.68 rifampicin
rpoB 762158 c.2352G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.67 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.62 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.59 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762323 c.2517C>A synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.5 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.47 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.46 rifampicin
rpoB 762350 c.2544C>G synonymous_variant 0.45 rifampicin
rpoB 762353 c.2547C>T synonymous_variant 0.47 rifampicin
rpoB 762356 p.Glu850Asp missense_variant 0.46 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.49 rifampicin
rpoB 762368 p.Glu854Asp missense_variant 0.51 rifampicin
rpoC 762374 c.-996G>T upstream_gene_variant 0.5 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.52 rifampicin
rpoC 762383 c.-987C>G upstream_gene_variant 0.54 rifampicin
rpoC 762392 c.-978G>C upstream_gene_variant 0.53 rifampicin
rpoC 762395 c.-975G>T upstream_gene_variant 0.51 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.51 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762410 c.2604T>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762449 c.2643C>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.41 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.41 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762533 c.-837T>C upstream_gene_variant 0.31 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.31 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.3 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.26 rifampicin
rpoC 762557 c.-813G>A upstream_gene_variant 0.21 rifampicin
rpoC 762560 c.-810A>C upstream_gene_variant 0.18 rifampicin
rpoC 762563 c.-807G>T upstream_gene_variant 0.15 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.11 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762866 c.3060C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.36 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.5 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763145 c.3339G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763157 c.3351G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763179 c.-191C>T upstream_gene_variant 0.42 rifampicin
rpoB 763193 c.3387C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>G upstream_gene_variant 0.29 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.27 rifampicin
rpoB 763207 p.Ser1134Lys missense_variant 0.27 rifampicin Uncertain significance
rpoB 763214 c.3408T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763217 c.-153G>C upstream_gene_variant 0.26 rifampicin
rpoC 763220 c.-150G>C upstream_gene_variant 0.26 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.26 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.26 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.26 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763241 p.Glu1145Asp missense_variant 0.27 rifampicin
rpoC 763259 c.-111G>C upstream_gene_variant 0.25 rifampicin
rpoC 763262 c.-108C>T upstream_gene_variant 0.25 rifampicin
rpoC 763265 c.-105G>C upstream_gene_variant 0.24 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>C synonymous_variant 0.31 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763415 c.46_48delACCinsTG frameshift_variant&missense_variant 0.32 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.33 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCA frameshift_variant&missense_variant 0.33 rifampicin
rpoC 763433 c.64_66delCAAinsAC frameshift_variant&missense_variant 0.33 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.33 rifampicin
rpoC 763450 c.81G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763609 c.240C>T synonymous_variant 0.33 rifampicin
rpoC 763621 c.252C>T synonymous_variant 0.34 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.34 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.33 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.33 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.33 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.33 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.33 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.32 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.31 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.27 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.19 rifampicin
rpoC 763781 p.Ser138Thr missense_variant 0.15 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.15 rifampicin
rpoC 763836 p.Ala156Glu missense_variant 0.14 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.15 rifampicin
rpoC 763844 p.Arg159Lys missense_variant 0.16 rifampicin
rpoC 763857 p.Glu163Ala missense_variant 0.16 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.16 rifampicin
rpoC 763870 c.501C>T synonymous_variant 0.16 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.16 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.19 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.2 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.2 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.2 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.2 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763933 c.564C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.29 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.29 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.29 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.24 rifampicin
rpoC 763991 c.622_624delATCinsCT frameshift_variant&missense_variant 0.24 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.25 rifampicin
rpoC 763999 c.630C>T synonymous_variant 0.24 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.24 rifampicin
rpoC 764003 p.Ala212Ser missense_variant 0.23 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.23 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.22 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.23 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.29 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.3 rifampicin
rpoC 764054 c.685C>T synonymous_variant 0.31 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.28 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.22 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.22 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764143 c.774G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764147 c.778_780delTCGinsGC frameshift_variant&missense_variant 0.23 rifampicin
rpoC 764150 c.781_783delATCinsGG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 764165 p.Glu266Gln missense_variant 0.22 rifampicin
rpoC 764176 c.807C>T synonymous_variant 0.16 rifampicin
rpoC 764177 p.Ile270Leu missense_variant 0.16 rifampicin
rpoC 764182 c.813C>T synonymous_variant 0.15 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>C synonymous_variant 0.13 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.16 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>G synonymous_variant 0.18 rifampicin
rpoC 764254 c.885G>C synonymous_variant 0.17 rifampicin
rpoC 764266 c.897T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764278 c.909A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764279 c.910_912delCAGinsAC frameshift_variant&missense_variant 0.13 rifampicin
rpoC 764284 c.915G>C synonymous_variant 0.13 rifampicin
rpoC 764285 p.Gly306Thr missense_variant 0.13 rifampicin
rpoC 764293 c.924G>A synonymous_variant 0.13 rifampicin
rpoC 764297 p.Met310Gly missense_variant 0.12 rifampicin
rpoC 764311 c.942C>G synonymous_variant 0.15 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.17 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.18 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764362 c.993C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.45 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.46 rifampicin
rpoC 764428 c.1059G>T synonymous_variant 0.52 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.52 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.59 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764509 c.1140G>A synonymous_variant 0.55 rifampicin
rpoC 764510 c.1141C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>A synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>A synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.7 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764683 c.1314G>A synonymous_variant 0.71 rifampicin
rpoC 764692 c.1323C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.67 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.67 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.57 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.57 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765001 c.1632C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.13 rifampicin
rpoC 765100 c.1731G>T synonymous_variant 0.14 rifampicin
rpoC 765103 c.1734G>T synonymous_variant 0.14 rifampicin
rpoC 765403 c.2034G>C synonymous_variant 0.15 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.15 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765449 c.2080_2082delGCCinsTG frameshift_variant&missense_variant 0.16 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766975 c.3606C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Ser missense_variant 0.6 rifampicin Uncertain significance
rpoC 767191 c.3822C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 0.59 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.57 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767254 c.3885G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 767264 c.3895_3897delGCGinsTC frameshift_variant&missense_variant 0.45 rifampicin
rpoC 767267 p.Ala1300Asn missense_variant 0.44 rifampicin Uncertain significance
rpoC 767281 c.3912C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781559 c.-1G>C upstream_gene_variant 0.25 streptomycin
rpsL 781572 c.13_15delCAGinsAC frameshift_variant&missense_variant 0.31 streptomycin Uncertain significance
rpsL 781586 c.27C>T synonymous_variant 0.34 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.34 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.35 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.34 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.34 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.33 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.33 streptomycin
rpsL 781658 c.99A>C synonymous_variant 0.35 streptomycin Not assoc w R - Interim
rpsL 781670 c.111G>C synonymous_variant 0.39 streptomycin
rpsL 781706 c.147T>C synonymous_variant 0.28 streptomycin
rpsL 781715 c.156T>G synonymous_variant 0.23 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.21 streptomycin
rpsL 781725 p.Lys56Arg missense_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.19 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.18 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.18 streptomycin
rpsL 781737 p.Gln60Ala missense_variant 0.18 streptomycin
rpsL 781742 c.183C>G synonymous_variant 0.18 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.23 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.24 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.26 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.28 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.28 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.31 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.3 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.31 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.28 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.28 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.32 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.34 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.35 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.35 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.31 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.3 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.26 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.25 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.23 streptomycin Uncertain significance
rplC 800720 c.-89T>C upstream_gene_variant 0.13 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.13 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.14 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
sigE 1364670 c.258G>A synonymous_variant 0.15 pyrazinamide
sigE 1364676 c.264C>T synonymous_variant 0.15 pyrazinamide
sigE 1364680 p.Gln90Glu missense_variant 0.16 pyrazinamide
sigE 1364685 c.273C>T synonymous_variant 0.15 pyrazinamide
sigE 1364691 c.279T>C synonymous_variant 0.15 pyrazinamide
sigE 1364694 c.282G>C synonymous_variant 0.15 pyrazinamide
sigE 1364703 c.291G>C synonymous_variant 0.16 pyrazinamide
sigE 1364709 c.297T>G synonymous_variant 0.17 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.17 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.17 pyrazinamide
sigE 1364726 p.Asn105Ser missense_variant 0.16 pyrazinamide
sigE 1364733 p.His107Gln missense_variant 0.16 pyrazinamide
sigE 1364742 c.330A>G synonymous_variant 0.17 pyrazinamide
sigE 1364751 c.339C>A synonymous_variant 0.17 pyrazinamide
sigE 1364757 c.345G>A synonymous_variant 0.17 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.14 pyrazinamide
sigE 1364778 c.366G>C synonymous_variant 0.14 pyrazinamide
sigE 1364782 c.370_372delGTCinsTG frameshift_variant&missense_variant 0.13 pyrazinamide Uncertain significance
Rv1258c 1406760 c.580_581insC frameshift_variant 0.98 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
Rv1258c 1406860 p.Gly161Ser missense_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide
atpE 1461113 c.69C>T synonymous_variant 0.13 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.19 bedaquiline
atpE 1461146 c.102G>T synonymous_variant 0.18 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.19 bedaquiline
atpE 1461161 c.117C>G synonymous_variant 0.19 bedaquiline
atpE 1461164 c.120C>T synonymous_variant 0.2 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.2 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.22 bedaquiline
atpE 1461179 c.135G>T synonymous_variant 0.21 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.22 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.23 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.22 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.2 bedaquiline
atpE 1461230 c.186G>T synonymous_variant 0.19 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.19 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472032 n.187G>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472043 n.198T>A non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472050 n.205G>C non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsAA non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472846 n.1001C>T non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474030 n.373G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474044 n.387C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474074 n.417C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474089 n.432C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1474100 n.443C>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474103 n.446A>C non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474106 n.449_450insCT non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474109 n.453_454delAT non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524_525insT non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474184 n.527C>A non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756A>C non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474415 n.759_781delCACACGCGCATACGCGCGTGTGA non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1474709 n.1052_1057delGTGGTGinsAATAAGT non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1474743 n.1086T>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.43 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476058 n.2401T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476085 n.2428G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476114 n.2457T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.62 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833517 c.-24delC upstream_gene_variant 0.14 pyrazinamide
rpsA 1833536 c.-6A>C upstream_gene_variant 0.26 pyrazinamide
rpsA 1833540 c.-2_-1delATinsC upstream_gene_variant 0.26 pyrazinamide
rpsA 1833547 c.6G>A synonymous_variant 0.28 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.41 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.42 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.42 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.45 pyrazinamide
rpsA 1833616 c.75A>T synonymous_variant 0.5 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.5 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.55 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.59 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.6 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.6 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.58 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.57 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.59 pyrazinamide
rpsA 1833697 c.156C>T synonymous_variant 0.59 pyrazinamide
rpsA 1833700 c.159C>T synonymous_variant 0.6 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.59 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.55 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.55 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.53 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.54 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.56 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.56 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.57 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.58 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.57 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.59 pyrazinamide
rpsA 1833823 c.282G>A synonymous_variant 0.56 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.57 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.58 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.57 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.57 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.6 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.64 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.65 pyrazinamide
rpsA 1833877 c.336C>G synonymous_variant 0.65 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.65 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.64 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.62 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.59 pyrazinamide
rpsA 1833958 c.417C>T synonymous_variant 0.58 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.58 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.6 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.62 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.6 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.55 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.51 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.48 pyrazinamide
rpsA 1834073 p.Lys178Arg missense_variant 0.36 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834228 c.687C>A synonymous_variant 0.48 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.47 pyrazinamide
rpsA 1834234 c.693G>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834240 c.699T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.49 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.52 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>T synonymous_variant 0.53 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.54 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.56 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.58 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>T synonymous_variant 0.59 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.58 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.59 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.59 pyrazinamide
rpsA 1834438 c.897C>T synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
rpsA 1834451 c.910T>C synonymous_variant 0.63 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.62 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.64 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834516 c.975G>A synonymous_variant 0.53 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834520 c.979_981delGCCinsTG frameshift_variant&missense_variant 0.53 pyrazinamide Uncertain significance
rpsA 1834528 c.987T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.57 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.54 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.53 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.54 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.53 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.48 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.52 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834645 c.1104C>T synonymous_variant 0.48 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.46 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834700 p.Gln387Ala missense_variant 0.49 pyrazinamide
rpsA 1834705 c.1164C>G synonymous_variant 0.47 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.46 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.39 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.35 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.37 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.36 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.26 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834813 c.1272G>T synonymous_variant 0.21 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.23 linezolid
tsnR 1853372 c.-234A>G upstream_gene_variant 0.24 linezolid
tsnR 1853375 c.-231G>C upstream_gene_variant 0.23 linezolid
tsnR 1853381 c.-225C>T upstream_gene_variant 0.23 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.23 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.24 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.23 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.24 linezolid
tsnR 1853417 c.-189G>C upstream_gene_variant 0.21 linezolid
tsnR 1853418 c.-188_-186delCTTinsTC upstream_gene_variant 0.2 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>C upstream_gene_variant 0.45 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.38 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.34 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.25 isoniazid
kasA 2517968 c.-147T>A upstream_gene_variant 0.21 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.16 isoniazid
kasA 2518726 c.612G>C synonymous_variant 0.15 isoniazid
kasA 2518738 c.624G>C synonymous_variant 0.16 isoniazid
Rv2477c 2783410 c.633G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783419 c.624G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783432 p.Ser204Thr missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783449 c.594C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783456 p.Gln196Leu missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783491 c.552C>T synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783509 c.534C>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783515 c.528C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783523 c.520C>T synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783568 p.Asn159His missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783584 c.457_459delGCCinsCG frameshift_variant&synonymous_variant 0.19 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783593 c.450T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625705 c.909C>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625708 c.906C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625720 c.894G>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625723 c.-813C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625744 c.870G>A synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.2 bedaquiline
rifampicin Uncertain significance
mtrB 3625761 p.Gln285Glu missense_variant 0.2 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625783 c.-873C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626684 c.-71G>A upstream_gene_variant 0.12 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626717 c.-104C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3626741 c.609C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626756 c.594C>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626762 c.588G>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626786 c.564A>G synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626804 c.546A>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626825 c.525T>A synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626843 c.-230G>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrA 3627053 c.297C>T synonymous_variant 0.13 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627056 c.294C>T synonymous_variant 0.13 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627059 c.-446G>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627073 c.277C>T synonymous_variant 0.18 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627110 c.-497G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627133 p.Ala73Ser missense_variant 0.21 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627143 c.-530G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627149 c.-536G>A upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627167 c.-554T>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627170 c.-557C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
rpoA 3877542 c.966C>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877545 c.963G>C synonymous_variant 0.19 rifampicin
rpoA 3877554 c.954G>C synonymous_variant 0.24 rifampicin
rpoA 3877560 c.948C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsAC frameshift_variant&missense_variant 0.28 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877614 c.894G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877620 c.888G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877665 c.843C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877677 c.831G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.34 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.34 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.35 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.35 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.36 rifampicin
rpoA 3877758 c.750G>C synonymous_variant 0.37 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.33 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.37 rifampicin
rpoA 3877797 c.711G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877815 c.693C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.43 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.4 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.28 rifampicin Uncertain significance
rpoA 3877974 c.534G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877977 p.Lys177Asn missense_variant 0.24 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>C synonymous_variant 0.28 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.28 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.28 rifampicin
rpoA 3878028 c.480G>T synonymous_variant 0.29 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.3 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.31 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.32 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.28 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.29 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.29 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.3 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.3 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.3 rifampicin
rpoA 3878091 c.417C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878102 p.Val136Ile missense_variant 0.36 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.37 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.38 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.41 rifampicin
rpoA 3878142 p.Gly122Asp missense_variant 0.35 rifampicin Uncertain significance
rpoA 3878154 c.354G>A synonymous_variant 0.43 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.44 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.43 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.48 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3878343 c.165C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.49 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.45 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.45 rifampicin
rpoA 3878373 c.135G>C synonymous_variant 0.38 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878400 c.108T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878403 c.105C>T synonymous_variant 0.25 rifampicin
rpoA 3878433 c.75G>C synonymous_variant 0.15 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.13 rifampicin
clpC1 4038842 c.1863G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038860 c.1845G>T synonymous_variant 0.34 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.38 pyrazinamide
clpC1 4038911 c.1794G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038914 c.1791G>T synonymous_variant 0.37 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.36 pyrazinamide
clpC1 4038923 c.1782A>T synonymous_variant 0.37 pyrazinamide
clpC1 4038928 c.1777C>A synonymous_variant 0.37 pyrazinamide
clpC1 4038929 c.1776G>A synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4038932 c.1773G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.42 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038992 c.1713C>T synonymous_variant 0.39 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039061 c.1644G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039077 p.Lys543Arg missense_variant 0.42 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.41 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.4 pyrazinamide
clpC1 4039094 c.1611C>T synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039097 c.1608G>T synonymous_variant 0.42 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039165 c.1540C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.47 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.48 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.44 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.46 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4039265 c.1440C>T synonymous_variant 0.5 pyrazinamide
clpC1 4039271 c.1434G>A synonymous_variant 0.49 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.43 pyrazinamide
clpC1 4039286 c.1417_1419delCTTinsTA frameshift_variant&synonymous_variant 0.42 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.43 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.45 pyrazinamide
clpC1 4039316 p.Glu463Asp missense_variant 0.48 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4039328 c.1377A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.4 pyrazinamide
clpC1 4039347 p.Arg453Ser missense_variant 0.4 pyrazinamide
clpC1 4039360 p.Ser449Arg missense_variant 0.45 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039391 c.1314T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.53 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.5 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.49 pyrazinamide Uncertain significance
clpC1 4039427 c.1278G>A synonymous_variant 0.54 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.55 pyrazinamide
clpC1 4039436 c.1269G>A synonymous_variant 0.54 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.53 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.54 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.6 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.63 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.63 pyrazinamide
clpC1 4039528 c.1177C>A synonymous_variant 0.65 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.67 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.67 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.68 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.68 pyrazinamide
clpC1 4039565 c.1140G>T synonymous_variant 0.68 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.67 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.64 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.7 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.68 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.66 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.65 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.64 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.64 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.64 pyrazinamide
clpC1 4039733 c.972G>T synonymous_variant 0.62 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.6 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.6 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.64 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.63 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.66 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.65 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.63 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.63 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.63 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.62 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.63 pyrazinamide
clpC1 4039868 c.837C>T synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4039913 c.792C>T synonymous_variant 0.59 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.52 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.51 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4040009 c.696C>G synonymous_variant 0.5 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.5 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.5 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.47 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.47 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>C synonymous_variant 0.47 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.46 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040141 c.564C>T synonymous_variant 0.29 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040168 c.537G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040174 c.531C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040297 c.408G>A synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040300 c.405C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040309 c.396C>T synonymous_variant 0.2 pyrazinamide
clpC1 4040333 c.372G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040342 c.363C>A synonymous_variant 0.19 pyrazinamide
clpC1 4040348 c.357G>T synonymous_variant 0.19 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.2 pyrazinamide
clpC1 4040366 c.339C>T synonymous_variant 0.19 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.22 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.22 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.27 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040456 c.249C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040462 c.243C>T synonymous_variant 0.22 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040495 c.210C>T synonymous_variant 0.31 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.33 pyrazinamide
clpC1 4040540 c.165G>T synonymous_variant 0.33 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040558 c.147G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.26 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.26 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.25 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.25 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.26 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.26 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.27 pyrazinamide
clpC1 4040642 c.61_63delAGGinsCC frameshift_variant&missense_variant 0.14 pyrazinamide
panD 4044150 c.132A>C synonymous_variant 0.3 pyrazinamide
panD 4044167 c.115C>T synonymous_variant 0.3 pyrazinamide
panD 4044171 c.111C>T synonymous_variant 0.29 pyrazinamide
panD 4044174 c.108C>T synonymous_variant 0.31 pyrazinamide
panD 4044180 p.Asp34Glu missense_variant 0.3 pyrazinamide
panD 4044186 c.94_96delTTGinsCC frameshift_variant&missense_variant 0.28 pyrazinamide Uncertain significance
panD 4044189 c.93C>T synonymous_variant 0.28 pyrazinamide
panD 4044194 p.Ala30Pro missense_variant 0.28 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.28 pyrazinamide
panD 4044219 c.63C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
panD 4044232 p.Cys17His missense_variant 0.27 pyrazinamide
panD 4044234 c.48C>G synonymous_variant 0.27 pyrazinamide
panD 4044240 c.42G>C synonymous_variant 0.27 pyrazinamide
panD 4044249 c.33C>T synonymous_variant 0.28 pyrazinamide
panD 4044266 p.Leu6Met missense_variant 0.28 pyrazinamide
panD 4044273 c.9G>C synonymous_variant 0.19 pyrazinamide
panD 4044276 p.Leu2Phe missense_variant 0.17 pyrazinamide
glpK 4138514 c.1242A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138517 c.1239A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138526 p.Asp410Glu missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138529 c.1227G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 p.Asp407Glu missense_variant 0.25 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138538 c.1218C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138550 c.1206C>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138556 c.1200G>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138559 c.1197G>A synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138562 c.1194G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138579 c.1177C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138601 c.1155G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138616 c.1140G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>A synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.5 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138664 c.1092G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.46 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138688 c.1068C>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138694 p.Pro354Glu missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138712 p.Ala348Asp missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1030_1032delGCAinsTG frameshift_variant&missense_variant 0.37 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138730 c.1026C>T synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138772 c.984G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138775 c.981C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243190 c.-43G>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247709 p.Asn399Thr missense_variant 1.0 ethambutol Uncertain significance
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R