TB-Profiler result

Run: ERR6866022
Summary

Run ID: ERR6866022

Sample name:

Date: 2024-04-14T00:18:56.826183

Number of reads: 253571

Percentage reads mapped: 14.84

Median coverage: 4.0

Strain: lineage4.8;lineage4.9

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.8 Euro-American (mainly T) RD219 0.08
lineage4.9 Euro-American (H37Rv-like) None 0.68
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.346_348delCACinsGG Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.838_840delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.87 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491620 c.838_840delATCinsGG frameshift_variant&missense_variant 1.0 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155764 c.346_348delCACinsGG frameshift_variant&missense_variant 0.77 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.92 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.9 isoniazid
dnaA 753 c.753C>T synonymous_variant 0.9 isoniazid
gyrB 6745 c.1506T>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrA 6769 c.-533C>T upstream_gene_variant 0.79 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.79 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.8 levofloxacin
moxifloxacin
gyrB 6808 c.1569C>T synonymous_variant 0.76 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.76 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7108 c.-194G>A upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 7126 c.-176G>A upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7135 c.-167G>A upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 7153 c.-149G>T upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrB 7159 c.1920C>T synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7162 c.1923C>T synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7165 c.-137C>T upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrA 7168 c.-134C>G upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.7 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.68 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7397 c.96G>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.74 levofloxacin
moxifloxacin
gyrA 7433 c.132G>A synonymous_variant 0.81 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.94 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.95 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 0.95 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7613 c.312G>A synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7637 c.336C>A synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 7706 c.405C>T synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 7709 c.408G>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.82 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.84 levofloxacin
moxifloxacin
gyrA 7775 c.474C>T synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7796 c.495G>T synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 8477 c.1176C>T synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8520 c.1219C>T synonymous_variant 0.77 levofloxacin
moxifloxacin
gyrA 8535 p.Glu412Gln missense_variant 0.71 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.8 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 8600 c.1299G>A synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.79 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.73 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.6 levofloxacin
moxifloxacin
gyrA 8799 p.Ala500Pro missense_variant 0.6 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8837 c.1536C>G synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8840 c.1539C>T synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8876 c.1575C>T synonymous_variant 0.64 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9296 c.1995T>C synonymous_variant 0.82 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 0.82 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9317 c.2016G>T synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9324 c.2023_2025delTCGinsAGC synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.8 levofloxacin
moxifloxacin
fgd1 491472 c.690A>G synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fgd1 491490 c.708C>T synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491500 p.Glu240Lys missense_variant 0.86 clofazimine
pretomanid
delamanid
fgd1 491508 c.726A>C synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fgd1 491523 c.741G>C synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491563 c.781_783delAGCinsTCG synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491595 c.813C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
mshA 575704 c.357T>C synonymous_variant 0.93 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.93 ethionamide
isoniazid
mshA 575725 c.378C>G synonymous_variant 0.9 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.91 ethionamide
isoniazid
mshA 575744 p.Ala133Thr missense_variant 0.92 ethionamide
isoniazid Uncertain significance
mshA 575749 c.402C>A synonymous_variant 0.92 ethionamide
isoniazid
mshA 575764 c.417C>G synonymous_variant 0.93 ethionamide
isoniazid
mshA 575771 p.Val142Thr missense_variant 0.93 ethionamide
isoniazid
mshA 575776 c.429C>T synonymous_variant 0.93 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.93 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.93 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.96 ethionamide
isoniazid
mshA 575800 c.453G>C synonymous_variant 0.96 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.96 ethionamide
isoniazid Not assoc w R - Interim
mshA 575821 c.474G>C synonymous_variant 0.96 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.95 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.94 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.85 ethionamide
isoniazid
mshA 575906 c.559_561delGCAinsTC frameshift_variant&missense_variant 0.7 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575916 p.Asp190Ala missense_variant 0.7 ethionamide
isoniazid
mshA 575920 c.573C>T synonymous_variant 0.7 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575925 p.Gly193Ala missense_variant 0.7 ethionamide
isoniazid
mshA 575929 c.582C>G synonymous_variant 0.7 ethionamide
isoniazid
mshA 575935 c.588G>A synonymous_variant 0.7 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.7 ethionamide
isoniazid
mshA 575945 p.Thr200Ala missense_variant 0.7 ethionamide
isoniazid
mshA 575950 c.603C>G synonymous_variant 0.7 ethionamide
isoniazid
ccsA 620649 c.759A>G synonymous_variant 0.91 capreomycin
amikacin
kanamycin
ccsA 620652 c.762C>G synonymous_variant 0.92 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.92 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.82 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 0.81 capreomycin
amikacin
kanamycin
ccsA 620715 c.825C>T synonymous_variant 0.8 capreomycin
amikacin
kanamycin
ccsA 620730 c.840C>T synonymous_variant 0.83 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.82 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.82 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.82 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>C synonymous_variant 0.82 capreomycin
amikacin
kanamycin
ccsA 620764 c.874_876delGCCinsTG frameshift_variant&missense_variant 0.82 capreomycin
amikacin
kanamycin
nusG 734421 c.168A>C synonymous_variant 0.79 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.8 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.9 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.88 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.88 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
nusG 734478 c.225C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.9 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.79 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.71 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.57 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 1.0 rifampicin Uncertain significance
rpoB 760136 c.330G>A synonymous_variant 1.0 rifampicin
rpoB 760139 c.333A>T synonymous_variant 1.0 rifampicin
rpoB 760142 c.336C>G synonymous_variant 1.0 rifampicin
rpoB 760178 c.372G>A synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.82 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.81 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.88 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.88 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.9 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.88 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.89 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.89 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.82 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.81 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.76 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.73 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.73 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.76 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.7 rifampicin
rpoB 760585 p.Asn260Ser missense_variant 0.73 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.73 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.76 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.77 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.8 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.86 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.82 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.79 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.81 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.81 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.83 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.87 rifampicin
rpoB 760784 c.978G>T synonymous_variant 0.9 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.89 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.89 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.89 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.89 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.92 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 0.91 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.9 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.9 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.9 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.83 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.83 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.83 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760958 c.1152G>C synonymous_variant 0.75 rifampicin
rpoB 760965 p.Met387Leu missense_variant 0.75 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.79 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 1.0 rifampicin
rpoB 761217 p.Pro471Ser missense_variant 1.0 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761240 c.1434C>T synonymous_variant 1.0 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.96 rifampicin
rpoB 761288 c.1482G>T synonymous_variant 0.95 rifampicin
rpoB 761318 c.1512G>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.94 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 0.94 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.93 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.8 rifampicin
rpoB 761366 c.1560C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761367 p.Glu521Gln missense_variant 0.8 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.8 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.77 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.82 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.83 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.82 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.74 rifampicin
rpoB 761708 c.1902C>T synonymous_variant 0.69 rifampicin
rpoB 761712 p.Val636Ile missense_variant 0.73 rifampicin
rpoB 761727 p.Ser641Ala missense_variant 0.71 rifampicin
rpoB 761736 p.Ile644Val missense_variant 0.73 rifampicin Uncertain significance
rpoB 761747 c.1941G>C synonymous_variant 0.76 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.74 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.67 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.67 rifampicin
rpoB 761785 p.Thr660Ser missense_variant 0.67 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.65 rifampicin
rpoB 761828 c.2022C>T synonymous_variant 0.58 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.87 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.88 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.9 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.91 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.81 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762308 c.2502G>C synonymous_variant 0.83 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.87 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.88 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.88 rifampicin
rpoB 762350 c.2544C>T synonymous_variant 0.88 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.92 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.92 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.92 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.93 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.93 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.93 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.93 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.93 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.96 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.93 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.86 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 762533 c.-837T>C upstream_gene_variant 0.8 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.8 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.8 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.64 rifampicin
rpoB 762833 c.3027C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.89 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.89 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.83 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.84 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.86 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.82 rifampicin
rpoC 763190 c.-180C>T upstream_gene_variant 0.77 rifampicin
rpoC 763199 c.-171G>C upstream_gene_variant 0.7 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>C synonymous_variant 0.71 rifampicin
rpoC 763414 c.45T>C synonymous_variant 0.71 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.77 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCT frameshift_variant&missense_variant 0.77 rifampicin
rpoC 763433 c.64_66delCAAinsAC frameshift_variant&missense_variant 0.77 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.79 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>T synonymous_variant 0.95 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763588 c.219C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.97 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.92 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.89 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.88 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.85 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.84 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.83 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.87 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.92 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.92 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.92 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.87 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.8 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.81 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.85 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.88 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.88 rifampicin
rpoC 763882 c.513G>A synonymous_variant 0.88 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.88 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.88 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.88 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.88 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.88 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.88 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.86 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.86 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.79 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.77 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.79 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.79 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.91 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.9 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.9 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.91 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.92 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.9 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.85 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.86 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.83 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764195 c.826_828delTCGinsAGC synonymous_variant 0.74 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.71 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.71 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.71 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.71 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.71 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 0.76 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.76 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.72 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.71 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.75 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.68 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.76 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.87 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.95 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.96 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.96 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.96 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.93 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.93 rifampicin
rpoC 764512 c.1143G>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.88 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.87 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.86 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.79 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.79 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.82 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1644delAGCinsTCG synonymous_variant 0.77 rifampicin
rpoC 765016 c.1647C>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.73 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 765383 c.2014_2016delATGinsCC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 765403 c.2034G>C synonymous_variant 1.0 rifampicin
rpoC 765404 p.Leu679Lys missense_variant 1.0 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 1.0 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 1.0 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 1.0 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 1.0 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 1.0 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 1.0 rifampicin Uncertain significance
rpoC 765496 c.2127C>G synonymous_variant 1.0 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.84 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.8 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.87 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.92 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.95 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.95 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.9 rifampicin
rpoC 765961 c.2592G>T synonymous_variant 0.9 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.9 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 766012 c.2643C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.83 rifampicin
rpoC 766027 c.2658G>T synonymous_variant 0.8 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.62 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.62 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.67 rifampicin
rpoC 766634 p.Phe1089Ile missense_variant 0.67 rifampicin
rpoC 766638 p.Lys1090Thr missense_variant 0.67 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.67 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.64 rifampicin
rpoC 766658 c.3289_3291delCGGinsGC frameshift_variant&missense_variant 0.62 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.68 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.68 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 0.68 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.67 rifampicin
rpoC 766694 c.3325_3327delCAGinsGC frameshift_variant&missense_variant 0.68 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.77 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.77 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.81 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.81 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.82 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.82 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.74 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.78 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.78 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 766948 c.3579G>C synonymous_variant 0.64 rifampicin
rpoC 766981 c.3612T>C synonymous_variant 0.75 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.86 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.96 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.96 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.93 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.93 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.89 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767296 c.3927C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
mmpL5 775817 c.2664T>C synonymous_variant 0.75 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775826 c.2655G>C synonymous_variant 0.76 clofazimine
bedaquiline
mmpL5 775829 c.2652C>G synonymous_variant 0.81 clofazimine
bedaquiline
mmpL5 775834 p.Ala883Ser missense_variant 0.75 clofazimine
bedaquiline
mmpL5 775838 c.2643G>C synonymous_variant 0.79 clofazimine
bedaquiline
mmpL5 775851 p.Ser877Thr missense_variant 0.82 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.91 clofazimine
bedaquiline
mmpL5 775865 c.2616T>C synonymous_variant 0.93 clofazimine
bedaquiline
mmpL5 775877 c.2604C>G synonymous_variant 0.86 clofazimine
bedaquiline
mmpL5 775883 c.2596_2598delATCinsTG frameshift_variant&missense_variant 0.86 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775886 c.2595A>G synonymous_variant 0.95 clofazimine
bedaquiline
mmpL5 775892 c.2589C>T synonymous_variant 0.9 clofazimine
bedaquiline
mmpL5 775904 c.2577G>A synonymous_variant 0.91 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.9 clofazimine
bedaquiline
mmpL5 775915 p.Ala856Ser missense_variant 0.84 clofazimine
bedaquiline
mmpL5 775916 c.2565T>C synonymous_variant 0.97 clofazimine
bedaquiline
mmpL5 775921 c.2560C>T synonymous_variant 0.85 clofazimine
bedaquiline
mmpL5 775924 c.2557C>T synonymous_variant 0.85 clofazimine Not assoc w R - Interim
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.91 clofazimine
bedaquiline
mmpL5 775955 c.2524_2526delATCinsGG frameshift_variant&missense_variant 0.45 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775964 c.2515_2517delGCGinsTC frameshift_variant&missense_variant 0.35 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775970 c.2511G>C synonymous_variant 0.79 clofazimine
bedaquiline
mmpL5 775973 c.2506_2508delTTGinsCC frameshift_variant&missense_variant 0.35 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775981 p.Leu834Met missense_variant 0.96 clofazimine
bedaquiline
mmpL5 775994 c.2485_2487delATCinsCG frameshift_variant&missense_variant 0.79 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775997 c.2484T>G synonymous_variant 0.92 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 0.79 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776005 p.Ile826Leu missense_variant 0.79 clofazimine
bedaquiline
mmpL5 776009 c.2472A>G synonymous_variant 0.8 clofazimine
bedaquiline
mmpL5 776030 c.2451G>C synonymous_variant 0.92 clofazimine
bedaquiline
rpsL 781572 c.13_15delCAGinsAC frameshift_variant&missense_variant 0.73 streptomycin Uncertain significance
rpsL 781595 c.36T>C synonymous_variant 0.65 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.69 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.65 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.65 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.71 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.73 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.79 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.83 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.81 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.85 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.82 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.81 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.81 streptomycin
rpsL 781732 c.174_177delGAGT frameshift_variant 0.81 streptomycin Uncertain significance
rpsL 781739 c.180_181insCGGC frameshift_variant 0.81 streptomycin Uncertain significance
rpsL 781742 c.183C>T synonymous_variant 0.83 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.89 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.93 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.94 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.9 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.9 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.9 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.91 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.91 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.94 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.91 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.9 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.9 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.9 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.91 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.9 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.9 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.9 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.9 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.9 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.88 streptomycin Uncertain significance
rplC 800570 c.-239C>G upstream_gene_variant 0.83 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.91 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.91 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 1.0 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 1.0 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.9 linezolid
rplC 800603 c.-206G>C upstream_gene_variant 1.0 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 1.0 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 1.0 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 1.0 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 1.0 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 1.0 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.95 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 0.9 linezolid
rplC 800684 c.-125G>A upstream_gene_variant 0.9 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.86 linezolid
rplC 800702 c.-107G>A upstream_gene_variant 0.74 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.74 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.74 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.74 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.74 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.72 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.71 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.71 linezolid
rplC 800862 c.54C>T synonymous_variant 0.7 linezolid
rplC 800865 c.57A>G synonymous_variant 0.7 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.7 linezolid
rplC 800873 p.Arg22Lys missense_variant 0.7 linezolid
rplC 800877 c.69A>C synonymous_variant 0.7 linezolid
rplC 800880 c.72A>C synonymous_variant 0.7 linezolid
rplC 800889 c.81C>G synonymous_variant 0.77 linezolid
rplC 800892 c.84G>C synonymous_variant 0.77 linezolid
rplC 800895 c.87C>G synonymous_variant 0.79 linezolid
rplC 800904 c.96G>C synonymous_variant 0.75 linezolid
rplC 800916 c.108A>G synonymous_variant 0.75 linezolid
rplC 800921 p.Arg38Leu missense_variant 0.75 linezolid
rplC 800928 c.120C>T synonymous_variant 0.75 linezolid
rplC 800931 c.123G>C synonymous_variant 0.75 linezolid
rplC 800937 c.129A>G synonymous_variant 0.8 linezolid
rplC 800946 c.138T>C synonymous_variant 0.8 linezolid
rplC 800949 c.141T>C synonymous_variant 0.8 linezolid
rplC 800964 c.156G>C synonymous_variant 0.85 linezolid
rplC 800985 c.177A>G synonymous_variant 0.82 linezolid
rplC 801220 p.Ser138Ala missense_variant 0.7 linezolid
rplC 801231 c.423C>T synonymous_variant 0.7 linezolid
rplC 801237 c.429G>A synonymous_variant 0.64 linezolid
rplC 801252 c.444G>C synonymous_variant 0.69 linezolid
rplC 801264 c.456C>T synonymous_variant 0.58 linezolid
rplC 801267 c.459A>C synonymous_variant 0.58 linezolid
rplC 801276 c.468G>C synonymous_variant 0.64 linezolid
rplC 801281 p.Ala158Gly missense_variant 0.58 linezolid
rplC 801285 c.477G>C synonymous_variant 0.58 linezolid
rplC 801307 c.499_501delGCCinsTG frameshift_variant&missense_variant 0.58 linezolid
rplC 801312 c.504G>C synonymous_variant 0.58 linezolid
rplC 801315 c.507G>T synonymous_variant 0.58 linezolid
rplC 801324 c.516T>C synonymous_variant 0.55 linezolid
fbiC 1304526 c.1596T>A synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304541 c.1611C>A synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304546 p.Val539Ala missense_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304562 c.1632G>C synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304567 p.Phe546Tyr missense_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>T synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.86 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
sigE 1364820 c.408A>G synonymous_variant 0.67 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.77 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.77 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.69 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.69 pyrazinamide
sigE 1364871 c.459C>T synonymous_variant 0.69 pyrazinamide
sigE 1364877 c.465G>T synonymous_variant 0.69 pyrazinamide
sigE 1364883 c.471G>A synonymous_variant 0.71 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.71 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.69 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.77 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.77 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.77 pyrazinamide
sigE 1364931 c.519C>T synonymous_variant 0.71 pyrazinamide
sigE 1364950 c.538_540delGCAinsTC frameshift_variant&missense_variant 0.73 pyrazinamide Uncertain significance
sigE 1364962 c.550_552delCCTinsGC frameshift_variant&missense_variant 0.6 pyrazinamide Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473717 n.60G>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473811 n.154_155insT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473814 n.158delT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473829 n.172G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474288 n.631_632delCCinsTCGACT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474292 n.635T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474294 n.638_649delCTCTCCGGAGGA non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.88 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476746 n.3089T>C non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476747 n.3090C>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476754 n.3097G>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rpsA 1833589 c.48A>C synonymous_variant 0.86 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.8 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.8 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.81 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.8 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.76 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.79 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.76 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.77 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.77 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.79 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.81 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.75 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.73 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
rpsA 1833709 c.168C>T synonymous_variant 0.77 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.8 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.8 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.8 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.8 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.81 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.83 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.87 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.89 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.89 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.85 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.86 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.81 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.81 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.8 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.8 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.81 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.82 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.81 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.84 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.85 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.88 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.94 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.92 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.92 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.92 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.91 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.91 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.94 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.94 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.94 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.94 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.94 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.82 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.82 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.83 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.81 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.81 pyrazinamide
rpsA 1834168 c.627C>T synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
rpsA 1834169 p.Thr210Ala missense_variant 0.81 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.92 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.87 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.91 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.91 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.89 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.86 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.86 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.89 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.89 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.86 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.85 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.85 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.83 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.85 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.84 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.83 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.89 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.88 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.91 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.94 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.93 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.88 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.83 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.86 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.84 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.84 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 0.9 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.88 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.9 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834663 c.1122C>T synonymous_variant 0.88 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.88 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.88 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.89 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.89 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.86 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.85 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.85 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.85 pyrazinamide
rpsA 1834771 c.1230G>A synonymous_variant 0.83 pyrazinamide
rpsA 1834774 c.1233C>G synonymous_variant 0.83 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.83 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.83 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.83 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.83 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.77 pyrazinamide
rpsA 1834829 c.1288_1290delGCGinsAC frameshift_variant&missense_variant 0.82 pyrazinamide Uncertain significance
tsnR 1853361 c.-245T>C upstream_gene_variant 0.73 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.79 linezolid
tsnR 1853375 c.-231G>T upstream_gene_variant 0.85 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.85 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.85 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.85 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.85 linezolid
tsnR 1853417 c.-189G>C upstream_gene_variant 0.73 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.73 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.64 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.64 linezolid
katG 2155691 c.421T>C synonymous_variant 0.9 isoniazid
katG 2155696 p.Ala139Val missense_variant 0.91 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.83 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.83 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.83 isoniazid
katG 2155742 p.Gly124Arg missense_variant 0.83 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.77 isoniazid
katG 2155749 c.363C>T synonymous_variant 0.77 isoniazid Not assoc w R - Interim
katG 2155752 c.360C>T synonymous_variant 0.77 isoniazid
katG 2155769 p.Ile115Val missense_variant 0.77 isoniazid
katG 2155770 c.342C>G synonymous_variant 0.77 isoniazid
katG 2155782 c.330C>A synonymous_variant 0.73 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.93 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.92 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.92 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 0.92 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.91 isoniazid
kasA 2517980 c.-135C>T upstream_gene_variant 0.9 isoniazid
kasA 2518636 c.522C>A synonymous_variant 1.0 isoniazid
kasA 2518639 c.525G>T synonymous_variant 1.0 isoniazid
kasA 2518642 c.528A>G synonymous_variant 1.0 isoniazid
kasA 2518645 c.531G>C synonymous_variant 1.0 isoniazid
kasA 2518656 p.Ala181Gly missense_variant 1.0 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.94 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.95 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.95 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.95 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.95 isoniazid
kasA 2518697 p.Cys195Val missense_variant 0.94 isoniazid
kasA 2518708 c.594C>G synonymous_variant 0.9 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.86 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.86 isoniazid
kasA 2518726 c.612G>A synonymous_variant 0.86 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.87 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.83 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.83 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.65 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.59 isoniazid
kasA 2518785 p.Glu224Ala missense_variant 0.59 isoniazid
kasA 2518787 c.673_675delCGGinsGT frameshift_variant&missense_variant 0.59 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.59 isoniazid
kasA 2518795 c.681C>T synonymous_variant 0.59 isoniazid
kasA 2518813 c.699C>T synonymous_variant 0.76 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.75 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.72 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.69 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.69 isoniazid
Rv2477c 2783386 c.657G>C synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783419 c.624G>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 p.Pro206Lys missense_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065058 c.1134C>G synonymous_variant 0.9 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065061 c.1131C>T synonymous_variant 0.9 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065064 c.1128G>C synonymous_variant 0.9 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065070 c.1122C>T synonymous_variant 0.9 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065079 c.1113T>C synonymous_variant 0.82 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065082 c.1110G>T synonymous_variant 0.82 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065085 c.1105_1107delAGGinsCC frameshift_variant&missense_variant 0.82 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065088 c.1104A>G synonymous_variant 0.82 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065109 c.1081_1083delAGAinsCC frameshift_variant&missense_variant 0.82 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065126 p.Ser356Ala missense_variant 0.85 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065130 c.1062A>G synonymous_variant 0.92 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065133 c.1059T>C synonymous_variant 0.92 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065142 c.1050A>G synonymous_variant 0.93 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.93 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065154 c.1038G>A synonymous_variant 0.92 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065160 c.1032C>T synonymous_variant 0.92 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065166 c.1026C>G synonymous_variant 0.92 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065925 c.267G>C synonymous_variant 0.8 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065947 p.Gly82Ala missense_variant 0.8 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065997 c.195C>G synonymous_variant 0.9 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067802 c.144C>G synonymous_variant 0.6 para-aminosalicylic_acid
lpqB 3624636 p.His92Arg missense_variant 1.0 bedaquiline
rifampicin Uncertain significance
lpqB 3624643 p.Ile90Leu missense_variant 1.0 bedaquiline
rifampicin
lpqB 3624646 c.265T>C synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624650 c.261G>A synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624656 c.255C>T synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624673 p.Ala80Ser missense_variant 1.0 bedaquiline
rifampicin
lpqB 3624675 p.Asn79Ser missense_variant 1.0 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624701 c.210T>G synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624725 c.186G>T synonymous_variant 1.0 bedaquiline
rifampicin
mtrB 3625111 c.1503G>A synonymous_variant 0.73 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625117 c.-207T>G upstream_gene_variant 0.73 bedaquiline
rifampicin
lpqB 3625122 c.-212C>A upstream_gene_variant 0.73 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.7 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.73 bedaquiline
rifampicin
lpqB 3625135 c.-225A>C upstream_gene_variant 0.8 bedaquiline
rifampicin
lpqB 3625141 c.-231T>C upstream_gene_variant 0.8 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.75 bedaquiline
rifampicin
lpqB 3625156 c.-246G>C upstream_gene_variant 0.69 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.69 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.69 bedaquiline
rifampicin
lpqB 3625168 c.-258G>T upstream_gene_variant 0.69 bedaquiline
rifampicin
lpqB 3625183 c.-273G>C upstream_gene_variant 0.69 bedaquiline
rifampicin
lpqB 3625186 c.-276T>G upstream_gene_variant 0.69 bedaquiline
rifampicin
lpqB 3625195 c.-285A>G upstream_gene_variant 0.64 bedaquiline
rifampicin
lpqB 3625198 c.-288C>G upstream_gene_variant 0.6 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.6 bedaquiline
rifampicin
lpqB 3625204 c.-294G>C upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625207 c.-297C>G upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625243 c.-333T>G upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.62 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.56 bedaquiline
rifampicin
lpqB 3625615 c.-705G>T upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrB 3625623 p.Thr331Ala missense_variant 0.59 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3625636 p.Ala326Glu missense_variant 0.53 bedaquiline
rifampicin
lpqB 3625639 c.-729C>T upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3625645 c.969C>T synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625648 c.964_966delTATinsCC frameshift_variant&missense_variant 0.56 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625656 c.958T>C synonymous_variant 0.59 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625657 c.-747C>T upstream_gene_variant 0.59 bedaquiline
rifampicin
lpqB 3625663 c.-753G>A upstream_gene_variant 0.61 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.63 bedaquiline
rifampicin
mtrB 3625711 c.903C>T synonymous_variant 0.69 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625720 c.894G>C synonymous_variant 0.74 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.69 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrB 3625753 p.Ala287Gln missense_variant 0.64 bedaquiline
rifampicin
mtrB 3626792 c.-179G>C upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3626795 c.-182C>T upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3626798 c.-185T>A upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.6 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.67 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.6 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.75 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.85 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.85 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.85 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.86 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.83 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.72 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.75 rifampicin
rpoA 3877875 c.633T>A synonymous_variant 0.76 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.76 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.75 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.78 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.77 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.67 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>C synonymous_variant 0.73 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoA 3878061 c.447G>A synonymous_variant 0.79 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.81 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.83 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.88 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.89 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.97 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.93 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.93 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>A synonymous_variant 1.0 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 1.0 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3878238 c.270C>T synonymous_variant 1.0 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 1.0 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 1.0 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 1.0 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.95 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.89 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>A synonymous_variant 0.85 rifampicin
clpC1 4038519 p.Arg729Gln missense_variant 0.83 pyrazinamide
clpC1 4038541 c.2164C>T synonymous_variant 0.67 pyrazinamide
clpC1 4038551 c.2154C>G synonymous_variant 0.67 pyrazinamide
clpC1 4038563 c.2142C>T synonymous_variant 0.69 pyrazinamide
clpC1 4038584 c.2121G>A synonymous_variant 0.81 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.81 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.79 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.8 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.79 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.79 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.79 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.79 pyrazinamide
clpC1 4038660 c.2044_2045delTCinsAG synonymous_variant 0.77 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.77 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4038679 p.Pro676Ala missense_variant 0.85 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.91 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.97 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.97 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 0.94 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.93 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.89 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.91 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.91 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.91 pyrazinamide
clpC1 4038776 c.1929G>A synonymous_variant 0.91 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.91 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.91 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.89 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.88 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.85 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.89 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.93 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.88 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.88 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.88 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.89 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.89 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.91 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.95 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.95 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.94 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.95 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.95 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.96 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039064 c.1641C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 1.0 pyrazinamide
clpC1 4039100 c.1605C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.97 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.97 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.97 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.97 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.97 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.96 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.93 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.93 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.89 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.89 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.82 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.81 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.83 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.83 pyrazinamide
clpC1 4039320 p.Ala462Gly missense_variant 0.84 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.84 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.8 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.83 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.89 pyrazinamide Not assoc w R - Interim
clpC1 4039361 c.1344C>G synonymous_variant 0.85 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.83 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.83 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.85 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.82 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.81 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.81 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.79 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.79 pyrazinamide
clpC1 4039457 c.1248C>T synonymous_variant 0.79 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.79 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.78 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.78 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.78 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.78 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.82 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.86 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.89 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.9 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.89 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.88 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.87 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.91 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.88 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.92 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.92 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.84 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.86 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.87 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.87 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.9 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.9 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.93 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.93 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.96 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.96 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.95 pyrazinamide
clpC1 4039832 c.873C>A synonymous_variant 0.95 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039883 c.822G>A synonymous_variant 1.0 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.97 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 0.88 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.85 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.86 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.86 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.86 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.82 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.8 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>C synonymous_variant 0.88 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.88 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>T synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4040375 c.330G>C synonymous_variant 0.8 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.83 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.83 pyrazinamide
clpC1 4040390 c.315C>G synonymous_variant 0.77 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.8 pyrazinamide
clpC1 4040433 c.271_272delAGinsTC synonymous_variant 0.79 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.79 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.79 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.85 pyrazinamide
clpC1 4040462 c.243C>T synonymous_variant 0.83 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.77 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.77 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.77 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
clpC1 4040495 c.210C>G synonymous_variant 0.85 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.83 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.93 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.82 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.8 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.8 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.8 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.8 pyrazinamide
clpC1 4040591 c.114C>T synonymous_variant 0.8 pyrazinamide
clpC1 4040594 c.111G>T synonymous_variant 0.8 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.8 pyrazinamide
clpC1 4040600 c.105A>G synonymous_variant 0.8 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.8 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.8 pyrazinamide
clpC1 4040618 c.87C>G synonymous_variant 0.8 pyrazinamide
clpC1 4040648 c.57G>A synonymous_variant 0.8 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.8 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
panD 4044138 c.144T>C synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
glpK 4138634 c.1122G>C synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138646 c.1110G>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138661 c.1095T>C synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138727 c.1029C>G synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138747 c.1009C>T synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>A synonymous_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240777 c.915G>A synonymous_variant 0.82 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.82 ethambutol
embC 4240781 c.919_921delGCGinsAC frameshift_variant&missense_variant 0.82 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.82 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.82 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.82 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.82 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.55 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.55 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.55 ethambutol
embC 4241059 c.1197G>A synonymous_variant 0.55 ethambutol
embC 4241074 c.1212G>C synonymous_variant 0.64 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.6 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.56 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.53 ethambutol
embC 4241109 p.Ala416Gly missense_variant 0.53 ethambutol
embC 4241121 p.Ser420Asn missense_variant 0.56 ethambutol
embC 4241125 c.1263G>C synonymous_variant 0.56 ethambutol
embC 4241126 p.Leu422Met missense_variant 0.56 ethambutol
embC 4241129 c.1267C>T synonymous_variant 0.6 ethambutol
embC 4241137 c.1275G>A synonymous_variant 0.6 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.64 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.64 ethambutol
embC 4241147 p.Cys429Ile missense_variant 0.64 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.64 ethambutol
embC 4241161 c.1299C>T synonymous_variant 0.64 ethambutol
embC 4241168 c.1306C>T synonymous_variant 0.64 ethambutol Not assoc w R - Interim
embB 4247426 p.Gly305Gln missense_variant 0.82 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.83 ethambutol
embB 4247437 c.924A>C synonymous_variant 0.83 ethambutol
embB 4247440 c.927C>G synonymous_variant 0.83 ethambutol
embB 4247449 c.936C>T synonymous_variant 0.83 ethambutol
embB 4247455 c.942C>T synonymous_variant 0.83 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.85 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.85 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.94 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.9 ethambutol
embB 4247511 p.Tyr333Phe missense_variant 0.9 ethambutol
embB 4247527 c.1014G>C synonymous_variant 0.9 ethambutol
embB 4247536 c.1023C>A synonymous_variant 0.88 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.91 ethambutol
embB 4247555 c.1042_1044delCTGinsAC frameshift_variant&missense_variant 0.91 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.9 ethambutol
embB 4247572 c.1059A>C synonymous_variant 0.9 ethambutol
embB 4247578 c.1065_1066insATCTGT conservative_inframe_insertion 0.9 ethambutol
embB 4247581 c.1069_1074delGCCGGG conservative_inframe_deletion 0.9 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.9 ethambutol Not assoc w R - Interim
embB 4248112 c.1599C>G synonymous_variant 0.67 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.7 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.7 ethambutol Not assoc w R - Interim
embB 4248158 p.Cys549Ser missense_variant 0.7 ethambutol
embB 4248167 p.Thr552Ala missense_variant 0.7 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.91 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.91 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.91 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.92 ethambutol Not assoc w R - Interim
embB 4248225 p.Ala571Val missense_variant 0.92 ethambutol Uncertain significance
embB 4248242 p.Val577Ile missense_variant 0.82 ethambutol
embB 4248264 p.Phe584Cys missense_variant 0.8 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.6 ethambutol