TB-Profiler result

Run: SRR1180137

Summary

Run ID: SRR1180137

Sample name:

Date: 2024-03-24T16:39:27.675386

Number of reads: 1447846

Percentage reads mapped: 58.38

Median coverage: 31.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: RR-TB


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.91
lineage2.2 East-Asian (Beijing) RD105;RD207 0.95
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.796_798delATCinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.916_918delTTCinsGA Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491578 c.796_798delATCinsCG frameshift_variant&missense_variant 0.32 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.39 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1303846 c.916_918delTTCinsGA frameshift_variant&missense_variant 0.39 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.41 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 522 c.522T>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 525 c.525T>C synonymous_variant 0.26 isoniazid
dnaA 528 c.528G>T synonymous_variant 0.26 isoniazid
dnaA 531 c.531C>T synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 534 c.534T>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 558 c.558G>C synonymous_variant 0.33 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.34 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 585 c.585A>G synonymous_variant 0.36 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.37 isoniazid
dnaA 597 c.597C>G synonymous_variant 0.36 isoniazid Not assoc w R - Interim
dnaA 600 c.600T>C synonymous_variant 0.35 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.28 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.26 isoniazid
dnaA 630 c.630C>G synonymous_variant 0.24 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.22 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.22 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 798 c.798C>T synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.28 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.25 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.22 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.21 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.24 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.28 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.28 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.3 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.3 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.33 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.31 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.27 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.26 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.26 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.25 isoniazid
dnaA 1203 c.1203T>C synonymous_variant 0.28 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.29 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.31 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.28 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>G synonymous_variant 0.35 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.37 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.36 isoniazid
dnaA 1425 c.1425C>T synonymous_variant 0.19 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.19 isoniazid
dnaA 1441 c.1441C>T synonymous_variant 0.19 isoniazid
dnaA 1470 c.1470C>T synonymous_variant 0.17 isoniazid
gyrB 6142 c.903G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6196 c.957C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6215 p.Ser326Thr missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6286 c.1047T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6301 c.1062G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6313 c.-989C>T upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>T upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.29 levofloxacin Uncertain significance
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.48 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>T synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6838 c.-464C>T upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6853 c.-449A>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7165 c.-137C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7502 c.201C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7538 c.237G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7556 c.255C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7631 c.330G>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7733 c.432A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7769 c.468C>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7778 c.477G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7868 c.567C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8075 c.774G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8103 p.Ser268Ala missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.4 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 8552 c.1251C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8783 c.1482G>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8817 p.Ser506Ala missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8822 c.1521C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8843 c.1542G>A synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.48 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.5 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9002 c.1701C>T synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>G synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9065 c.1764C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9362 c.2061C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9365 c.2064G>A synonymous_variant 0.3 levofloxacin
moxifloxacin
Rv0010c 13876 c.-318G>C upstream_gene_variant 0.23 isoniazid
Rv0010c 13890 c.-332T>C upstream_gene_variant 0.37 isoniazid
Rv0010c 13893 c.-335T>G upstream_gene_variant 0.38 isoniazid
Rv0010c 13903 c.-345A>G upstream_gene_variant 0.41 isoniazid
fgd1 490887 c.105G>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491560 p.His260Thr missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491569 p.Asp263His missense_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491603 p.Ala274Glu missense_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575590 c.243T>G synonymous_variant 0.18 ethionamide
isoniazid
mshA 575746 c.399C>T synonymous_variant 0.25 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.22 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.22 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.31 ethionamide
isoniazid
mshA 575833 c.486C>T synonymous_variant 0.3 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575845 c.498C>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575878 c.531A>C synonymous_variant 0.38 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.39 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.39 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.38 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.73 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575938 c.591G>T synonymous_variant 0.35 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.32 ethionamide
isoniazid
mshA 575953 c.606G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575980 c.633T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 576004 c.657T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 576017 p.Val224Leu missense_variant 0.24 ethionamide
isoniazid
mshA 576022 c.675T>C synonymous_variant 0.23 ethionamide
isoniazid
ccsA 619591 c.-300G>C upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619594 c.-297G>C upstream_gene_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 619618 c.-273C>G upstream_gene_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>G upstream_gene_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 619668 c.-223_-222delCGinsGC upstream_gene_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>T upstream_gene_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 619676 c.-215C>G upstream_gene_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620198 p.Gln103Leu missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 656325 c.1146C>G synonymous_variant 0.29 ethionamide
Rv0565c 656502 c.969C>T synonymous_variant 0.25 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.32 ethionamide Not assoc w R - Interim
Rv0565c 656534 p.Arg313Gly missense_variant 0.33 ethionamide
Rv0565c 656538 p.Ser311Ala missense_variant 0.33 ethionamide
Rv0565c 656568 c.903G>C synonymous_variant 0.38 ethionamide
Rv0565c 656582 p.Leu297Met missense_variant 0.39 ethionamide
Rv0565c 656583 c.888A>G synonymous_variant 0.38 ethionamide
Rv0565c 656589 c.882T>C synonymous_variant 0.39 ethionamide
Rv0565c 656604 c.867G>C synonymous_variant 0.29 ethionamide
Rv0565c 656611 p.Thr287Lys missense_variant 0.22 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.97 ethionamide Uncertain significance
Rv0565c 657233 p.Ile80Val missense_variant 0.21 ethionamide
Rv0565c 657237 c.234A>G synonymous_variant 0.21 ethionamide
Rv0565c 657241 p.Glu77Arg missense_variant 0.2 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.23 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.2 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.23 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.23 ethionamide
Rv0565c 657291 c.180C>G synonymous_variant 0.25 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.25 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.35 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.39 ethionamide
hadA 731774 c.-156T>C upstream_gene_variant 0.2 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.2 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.21 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.22 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.21 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.4 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.43 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.41 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.47 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.5 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.51 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.51 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.51 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.5 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.56 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.56 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.42 rifampicin
nusG 734596 c.343_345delTTGinsCC frameshift_variant&missense_variant 0.38 rifampicin
nusG 734604 c.351C>T synonymous_variant 0.38 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.4 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.26 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.26 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.25 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.27 rifampicin Uncertain significance
nusG 734814 c.561G>C synonymous_variant 0.33 rifampicin
nusG 734826 c.573A>G synonymous_variant 0.33 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734841 c.588G>C synonymous_variant 0.29 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.29 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.25 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.26 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.26 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.24 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.27 rifampicin
rpoB 760067 c.261G>C synonymous_variant 0.27 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.29 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.59 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.6 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.62 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.49 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.49 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.52 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.51 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.51 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.53 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.48 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.43 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.42 rifampicin
rpoB 760403 c.597C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.38 rifampicin
rpoB 760520 c.714C>G synonymous_variant 0.38 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.36 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.29 rifampicin
rpoB 760547 c.741G>T synonymous_variant 0.35 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.36 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.48 rifampicin
rpoB 760598 c.792C>T synonymous_variant 0.47 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.51 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.39 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.39 rifampicin
rpoB 760765 p.Glu320Ala missense_variant 0.42 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.41 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.37 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.29 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.36 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.33 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.44 rifampicin
rpoB 760856 c.1050C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.39 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.36 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.43 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.41 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.41 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.41 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.39 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.24 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.38 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.4 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.43 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.4 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.31 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761361 c.1555_1556delAGinsTC synonymous_variant 0.24 rifampicin
rpoB 761373 p.Val523His missense_variant 0.27 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.24 rifampicin
rpoB 761504 c.1698C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.3 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.38 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.47 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761603 c.1797C>G synonymous_variant 0.5 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.49 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.38 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761660 c.1854G>A synonymous_variant 0.32 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.34 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.32 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.22 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.27 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.26 rifampicin
rpoB 761867 c.2061C>G synonymous_variant 0.3 rifampicin
rpoB 761870 p.Asp688Glu missense_variant 0.3 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.31 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.36 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.38 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.39 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.37 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.36 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.36 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.37 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.41 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.45 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.49 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762074 c.2268C>G synonymous_variant 0.51 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.47 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.41 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.47 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.55 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.52 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.5 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.53 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.53 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.52 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.49 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.47 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.5 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.54 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 762476 c.-894C>A upstream_gene_variant 0.54 rifampicin
rpoB 762489 p.Val895Gln missense_variant 0.5 rifampicin
rpoC 762512 c.-858C>G upstream_gene_variant 0.5 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.48 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.4 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.4 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 0.42 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.36 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.21 rifampicin
rpoC 762582 c.-788T>C upstream_gene_variant 0.2 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762833 c.3027C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 762863 c.-507T>G upstream_gene_variant 0.51 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.58 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.51 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.49 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.59 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.36 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.37 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.41 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>C upstream_gene_variant 0.35 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.33 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.33 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.31 rifampicin
rpoC 763402 c.33C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.43 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.55 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.53 rifampicin
rpoC 763501 c.132C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.51 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.26 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.29 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.25 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.22 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.19 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.22 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.23 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.24 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.25 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.26 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.26 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763930 c.561G>A synonymous_variant 0.19 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.19 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.19 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.38 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.35 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.35 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.33 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764198 c.829C>T synonymous_variant 0.33 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.35 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764213 p.Arg282Lys missense_variant 0.35 rifampicin Uncertain significance
rpoC 764257 c.888G>C synonymous_variant 0.44 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.45 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.45 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.41 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.49 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.47 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.46 rifampicin
rpoC 764428 c.1059G>A synonymous_variant 0.38 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.36 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.37 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.39 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.52 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.59 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.57 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.57 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.54 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.55 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.51 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.46 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.5 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.48 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.31 rifampicin Not assoc w R
rpoC 765300 p.Val644Ala missense_variant 0.28 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.26 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.27 rifampicin Uncertain significance
rpoC 765370 c.2001G>T synonymous_variant 0.28 rifampicin
rpoC 765371 c.2002C>T synonymous_variant 0.27 rifampicin
rpoC 765379 c.2010G>T synonymous_variant 0.3 rifampicin
rpoC 765383 c.2014_2016delATGinsCT frameshift_variant&missense_variant 0.31 rifampicin
rpoC 765394 c.2025G>A synonymous_variant 0.36 rifampicin
rpoC 765404 c.2035_2037delCTGinsGC frameshift_variant&missense_variant 0.31 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.31 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.3 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.36 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.5 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.52 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.55 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.6 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.54 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.55 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.57 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.5 rifampicin
rpoC 765646 c.2277G>A synonymous_variant 0.49 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.36 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.34 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.32 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.39 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.34 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.32 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.38 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.38 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.37 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.35 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>G synonymous_variant 0.42 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.3 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.29 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.33 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.34 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.38 rifampicin
rpoC 766080 c.2712_2715delTGCA frameshift_variant 0.4 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.37 rifampicin
rpoC 766097 p.Leu910Val missense_variant 0.37 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.29 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.24 rifampicin
rpoC 766148 p.Thr927Ala missense_variant 0.2 rifampicin Uncertain significance
rpoC 766294 c.2925C>T synonymous_variant 0.19 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766309 c.2940G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>C synonymous_variant 0.24 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.24 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.3 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.33 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.33 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.34 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.3 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.3 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.34 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.36 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.42 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.38 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.38 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.44 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.48 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.48 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.45 rifampicin
rpoC 766522 c.3153C>T synonymous_variant 0.5 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.47 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.45 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.53 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.44 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.38 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.37 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.38 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.4 rifampicin
rpoC 766618 c.3249G>C synonymous_variant 0.37 rifampicin
rpoC 766621 c.3252G>A synonymous_variant 0.37 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.4 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.36 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.38 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.38 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.51 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.6 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.64 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.53 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.47 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.39 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.38 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.33 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.31 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.38 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.31 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.42 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.43 rifampicin
rpoC 767065 c.3696G>A synonymous_variant 0.47 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767102 c.3733_3735delCTCinsTG frameshift_variant&missense_variant 0.44 rifampicin
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.44 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.45 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.26 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.28 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775883 c.2596_2598delATCinsCG frameshift_variant&missense_variant 0.19 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775886 c.2595A>C synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.38 clofazimine
bedaquiline
mmpL5 775913 c.2568C>G synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 0.36 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.3 clofazimine
bedaquiline
mmpL5 775975 c.2506T>C synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.3 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.31 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.35 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.32 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.35 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.32 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.36 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.45 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.38 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.44 streptomycin
rpsL 781718 c.159C>T synonymous_variant 0.47 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.48 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.49 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.5 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.48 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.47 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.35 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.3 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.31 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.29 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.26 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.26 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.48 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.6 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.59 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.41 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.52 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.54 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.57 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.49 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.48 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.5 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.48 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.44 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.5 linezolid
rplC 800703 c.-106_-104delTTGinsCC upstream_gene_variant 0.54 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.55 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.52 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.5 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.48 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.45 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.35 linezolid
rplC 801147 c.339T>C synonymous_variant 0.19 linezolid
rplC 801150 c.342G>C synonymous_variant 0.18 linezolid
rplC 801156 c.348T>C synonymous_variant 0.18 linezolid
rplC 801171 c.363A>G synonymous_variant 0.26 linezolid
rplC 801174 c.366T>C synonymous_variant 0.26 linezolid
rplC 801195 c.387G>C synonymous_variant 0.26 linezolid
rplC 801222 c.414T>C synonymous_variant 0.31 linezolid
rplC 801249 c.441T>C synonymous_variant 0.22 linezolid
rplC 801255 c.447C>T synonymous_variant 0.24 linezolid
rplC 801267 c.459A>T synonymous_variant 0.21 linezolid
rplC 801270 c.462T>C synonymous_variant 0.19 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303488 c.558G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Thr missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303794 c.864A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303890 c.960G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303897 c.967C>T synonymous_variant 0.36 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303908 c.978C>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303932 c.1002G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303935 c.1005G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304137 p.Ala403Ser missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304625 c.1695C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304796 c.1866G>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304880 c.1950C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304995 c.2065T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305014 p.Thr695Ser missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>A synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305039 c.2109G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305090 c.2160C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305096 c.2166T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305114 c.2184T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>C synonymous_variant 0.3 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305135 c.2205C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305144 c.2214G>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305273 c.2343C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305279 p.His783Gln missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305361 c.2431C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305396 c.2466C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305400 p.His824Tyr missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305430 p.Val834Ile missense_variant 0.17 clofazimine
pretomanid
delamanid
sigE 1365108 c.696A>C synonymous_variant 0.27 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
embR 1416310 c.1038G>C synonymous_variant 0.22 ethambutol
embR 1416313 c.1035A>G synonymous_variant 0.21 ethambutol
embR 1416316 c.1032C>A synonymous_variant 0.23 ethambutol
embR 1416324 p.Asn342Asp missense_variant 0.22 ethambutol
embR 1416330 p.Val340Ile missense_variant 0.24 ethambutol
embR 1416335 p.Asn338Gly missense_variant 0.24 ethambutol
embR 1416340 c.1008C>G synonymous_variant 0.24 ethambutol
embR 1416343 c.1005G>C synonymous_variant 0.24 ethambutol
embR 1416354 p.Ile332Val missense_variant 0.22 ethambutol
atpE 1460804 c.-241T>C upstream_gene_variant 0.43 bedaquiline
atpE 1460816 c.-229T>C upstream_gene_variant 0.58 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.62 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.56 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.54 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.57 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.54 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.2 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.25 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.25 bedaquiline
atpE 1461158 c.114T>C synonymous_variant 0.3 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.32 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.32 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.31 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.3 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.29 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.36 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.33 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.24 bedaquiline
atpE 1461251 c.207G>C synonymous_variant 0.22 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.18 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473936 n.279A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.41 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474288 n.632_634delCTT non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474294 n.638_649delCTCTCCGGAGGA non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476717 n.3060C>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476746 n.3089T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476759 n.3102T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476770 n.3113T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476771 n.3114G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
inhA 1674078 c.-124C>G upstream_gene_variant 0.26 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.26 ethionamide
isoniazid
inhA 1674084 c.-118C>G upstream_gene_variant 0.27 ethionamide
isoniazid
inhA 1674114 c.-88T>G upstream_gene_variant 0.27 ethionamide
isoniazid
inhA 1674123 c.-79T>C upstream_gene_variant 0.27 ethionamide
isoniazid
inhA 1674129 c.-73C>T upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1674132 c.-70T>C upstream_gene_variant 0.21 ethionamide
isoniazid
fabG1 1674136 p.Ser233Ala missense_variant 0.2 ethionamide
isoniazid
inhA 1674141 c.-61T>C upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1674255 c.54C>T synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674489 c.288G>T synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674540 c.339C>T synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.36 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.37 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.39 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.37 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.35 ethionamide
isoniazid
inhA 1674624 c.423A>T synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674729 c.528G>T synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674746 p.Tyr182Phe missense_variant 0.31 ethionamide
isoniazid
inhA 1674756 c.555T>A synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674840 c.639C>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.22 ethionamide
isoniazid
inhA 1674858 c.657G>A synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.21 ethionamide
isoniazid
inhA 1674934 c.733C>T synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674939 c.738G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674954 c.753G>T synonymous_variant 0.21 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.3 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.38 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.36 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.42 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1833793 c.252C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.4 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.39 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.49 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.43 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.44 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.46 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.4 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.37 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.19 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.4 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.47 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.51 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834546 c.1005T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.51 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.54 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.5 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.43 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.35 pyrazinamide
rpsA 1834775 p.Ala412Asn missense_variant 0.34 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.34 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834828 c.1287C>G synonymous_variant 0.29 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.24 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.27 linezolid
tsnR 1853375 c.-231G>T upstream_gene_variant 0.29 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.3 linezolid
tsnR 1853390 c.-216G>A upstream_gene_variant 0.3 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.32 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.36 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917945 c.6A>T synonymous_variant 0.16 capreomycin
tlyA 1917951 c.12T>C synonymous_variant 0.21 capreomycin
tlyA 1917981 c.42G>C synonymous_variant 0.23 capreomycin
ndh 2101960 c.1083A>G synonymous_variant 0.33 ethionamide
delamanid
isoniazid
ndh 2102260 c.783C>T synonymous_variant 0.37 ethionamide
delamanid
isoniazid
ndh 2102266 c.777C>G synonymous_variant 0.34 ethionamide
delamanid
isoniazid
ndh 2102317 c.726A>G synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102328 p.Leu239Met missense_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2102334 p.Gln237Glu missense_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2102337 c.706T>C synonymous_variant 0.29 ethionamide Not assoc w R - Interim
delamanid
isoniazid
ndh 2102644 c.399A>G synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102671 c.372T>G synonymous_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2102680 c.363T>G synonymous_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2102683 c.360T>C synonymous_variant 0.39 ethionamide
delamanid
isoniazid
ndh 2102686 c.357G>C synonymous_variant 0.38 ethionamide
delamanid
isoniazid
ndh 2102694 p.Val117Ile missense_variant 0.38 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102701 c.342C>T synonymous_variant 0.38 ethionamide
delamanid
isoniazid
ndh 2102710 c.333C>T synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102716 c.325_327delCAAinsGC frameshift_variant&missense_variant 0.28 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
katG 2154724 p.Arg463Leu missense_variant 0.96 isoniazid Not assoc w R
katG 2155596 c.516G>C synonymous_variant 0.24 isoniazid
katG 2155620 c.492G>C synonymous_variant 0.24 isoniazid
katG 2155632 c.480A>C synonymous_variant 0.38 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.38 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.39 isoniazid Uncertain significance
katG 2155680 c.432G>C synonymous_variant 0.34 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.34 isoniazid
katG 2155692 c.420C>T synonymous_variant 0.34 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.33 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.34 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.36 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.32 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.28 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.22 isoniazid
kasA 2517926 c.-189G>A upstream_gene_variant 0.28 isoniazid
kasA 2518183 c.69G>A synonymous_variant 0.38 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.35 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.31 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.3 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.18 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.2 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.28 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.26 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.25 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.31 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.32 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.32 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.32 isoniazid
kasA 2518591 c.477G>T synonymous_variant 0.31 isoniazid
kasA 2518597 c.483C>G synonymous_variant 0.34 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.29 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.27 isoniazid
kasA 2518621 c.507G>T synonymous_variant 0.25 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.27 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.31 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.36 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.32 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.32 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.32 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.33 isoniazid
kasA 2518696 c.582C>T synonymous_variant 0.3 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.29 isoniazid
kasA 2518705 c.591T>G synonymous_variant 0.3 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.28 isoniazid
kasA 2518714 c.600A>T synonymous_variant 0.28 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.28 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.17 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.26 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.24 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.29 isoniazid
ahpC 2726633 c.441C>G synonymous_variant 0.36 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.38 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.45 isoniazid
ahpC 2726651 c.459G>C synonymous_variant 0.45 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.42 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.45 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.42 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.39 isoniazid Not assoc w R - Interim
ahpC 2726684 c.492G>C synonymous_variant 0.38 isoniazid
ahpC 2726687 c.495C>G synonymous_variant 0.37 isoniazid
ahpC 2726693 c.501C>A synonymous_variant 0.37 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.38 isoniazid
folC 2746282 c.1317T>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2746285 c.1314T>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2746308 p.Arg431Ser missense_variant 0.23 para-aminosalicylic_acid
folC 2746321 c.1278A>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2746618 c.981G>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2746631 p.Gly323Val missense_variant 0.21 para-aminosalicylic_acid
folC 2747059 c.540T>C synonymous_variant 0.36 para-aminosalicylic_acid
folC 2747086 c.513A>C synonymous_variant 0.37 para-aminosalicylic_acid
folC 2747089 c.510G>C synonymous_variant 0.37 para-aminosalicylic_acid
folC 2747101 c.498G>C synonymous_variant 0.34 para-aminosalicylic_acid
folC 2747107 c.492G>C synonymous_variant 0.33 para-aminosalicylic_acid
folC 2747110 c.489T>C synonymous_variant 0.34 para-aminosalicylic_acid
folC 2747113 c.486C>G synonymous_variant 0.33 para-aminosalicylic_acid
folC 2747116 c.483G>C synonymous_variant 0.33 para-aminosalicylic_acid
folC 2747131 c.468C>G synonymous_variant 0.31 para-aminosalicylic_acid
folC 2747134 c.465C>G synonymous_variant 0.29 para-aminosalicylic_acid
folC 2747314 c.285A>T synonymous_variant 0.47 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.43 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.34 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.31 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.33 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.33 para-aminosalicylic_acid
folC 2747407 c.192T>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747408 c.190_191insGGCCT frameshift_variant 0.21 para-aminosalicylic_acid
folC 2747414 c.180_184delCCAAC frameshift_variant 0.24 para-aminosalicylic_acid
folC 2747442 c.157T>C synonymous_variant 0.37 para-aminosalicylic_acid
folC 2747467 p.Asp44Glu missense_variant 0.22 para-aminosalicylic_acid
Rv2477c 2782453 c.1590C>T synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782669 c.1374A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782680 c.1363T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782684 c.1359T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782705 c.1338G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782708 c.1335C>T synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782714 c.1329A>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782720 c.1323T>A synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782729 c.1314A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782732 c.1311A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782738 c.1305C>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782750 c.1293T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782759 c.1284A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.47 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.42 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783086 c.957C>T synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.46 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.46 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783116 c.927T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.46 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.45 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783193 p.Ser284Gly missense_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783244 p.Thr267Ala missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783305 c.738G>A synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTC frameshift_variant&missense_variant 0.38 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783629 c.414C>T synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783680 c.363G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783695 c.348C>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783950 c.93C>T synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.56 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.56 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859843 c.576G>C synonymous_variant 0.33 clofazimine
bedaquiline
pepQ 2859870 c.549T>C synonymous_variant 0.38 clofazimine
bedaquiline
pepQ 2859873 c.546T>C synonymous_variant 0.38 clofazimine
bedaquiline
pepQ 2859882 c.537G>C synonymous_variant 0.34 clofazimine
bedaquiline
pepQ 2859903 c.516G>C synonymous_variant 0.31 clofazimine
bedaquiline
pepQ 2859908 p.Gln171Glu missense_variant 0.28 clofazimine
bedaquiline
pepQ 2859909 c.510G>C synonymous_variant 0.28 clofazimine
bedaquiline
pepQ 2859918 c.501A>G synonymous_variant 0.23 clofazimine
bedaquiline
pepQ 2859921 c.498C>G synonymous_variant 0.24 clofazimine
bedaquiline
Rv2752c 3065463 c.729T>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065675 p.Phe173Leu missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065697 c.495C>T synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065700 c.492C>A synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065703 c.489A>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065886 c.306C>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065901 c.291A>C synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065946 p.Gly82Ala missense_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065955 c.235_237delTTGinsCC frameshift_variant&missense_variant 0.32 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067304 c.642A>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067313 c.633G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067319 c.627G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067616 c.330C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067676 c.270C>G synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067679 p.Cys89Leu missense_variant 0.38 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067693 p.Ile85Val missense_variant 0.34 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067702 p.Ile82Leu missense_variant 0.33 para-aminosalicylic_acid
thyX 3067713 p.Val78Ala missense_variant 0.32 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067788 p.Lys53Arg missense_variant 0.24 para-aminosalicylic_acid
thyX 3067790 c.156C>A synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067811 c.135G>A synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067838 c.108C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.33 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067877 c.69G>A synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067935 p.Thr4Ile missense_variant 0.26 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.46 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.4 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074142 c.330C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074147 p.Ile109Val missense_variant 0.19 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612640 c.477C>T synonymous_variant 0.19 pyrazinamide
Rv3236c 3612661 c.456G>C synonymous_variant 0.21 pyrazinamide
Rv3236c 3612667 c.450T>G synonymous_variant 0.21 pyrazinamide
Rv3236c 3612670 c.447G>C synonymous_variant 0.2 pyrazinamide
Rv3236c 3612685 c.432C>T synonymous_variant 0.2 pyrazinamide
Rv3236c 3612694 p.Arg141Gln missense_variant 0.2 pyrazinamide
Rv3236c 3612708 c.409T>C synonymous_variant 0.2 pyrazinamide
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3623417 c.1494A>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3623428 c.1483T>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624074 c.837G>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624077 c.834G>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624082 c.829A>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624089 c.822C>G synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624094 c.817A>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624100 c.811T>C synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624116 c.795A>G synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624119 c.792C>G synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624133 c.778A>C synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624166 p.Met249Leu missense_variant 0.21 bedaquiline
rifampicin
lpqB 3624188 c.723G>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624656 c.255C>T synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.36 bedaquiline
rifampicin Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625222 c.1392T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625240 c.-330T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625243 c.-333T>G upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625246 c.-336G>A upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625255 c.-345T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625258 c.-348G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625313 p.Arg434Lys missense_variant 0.16 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.38 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.42 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.45 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.43 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625687 c.-777G>T upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625702 c.-792C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625741 c.-831G>A upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.37 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625806 c.808A>C synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625852 c.762A>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625888 c.726G>A synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626325 p.Thr97Ala missense_variant 0.21 bedaquiline
rifampicin
mtrB 3626329 c.285G>A synonymous_variant 0.21 bedaquiline
rifampicin
mtrB 3626332 c.282T>C synonymous_variant 0.22 bedaquiline
rifampicin
mtrB 3626349 p.Ser89Gly missense_variant 0.31 bedaquiline
rifampicin
mtrB 3626350 c.264C>G synonymous_variant 0.31 bedaquiline
rifampicin
mtrB 3626377 p.Asp79Glu missense_variant 0.47 bedaquiline
rifampicin
mtrB 3626383 c.231G>C synonymous_variant 0.42 bedaquiline
rifampicin
mtrB 3626386 c.228G>C synonymous_variant 0.44 bedaquiline
rifampicin
mtrB 3626390 p.Arg75Lys missense_variant 0.38 bedaquiline
rifampicin
mtrB 3626400 p.Ile72Val missense_variant 0.41 bedaquiline
rifampicin
mtrB 3626407 c.207C>G synonymous_variant 0.35 bedaquiline
rifampicin
mtrB 3626410 c.204T>C synonymous_variant 0.32 bedaquiline
rifampicin
mtrB 3626425 c.189C>T synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626744 c.-131G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.36 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626849 c.-236C>T upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626959 c.-346C>T upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627005 c.-392G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3627023 c.-410C>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3627056 c.294C>T synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627065 c.-452G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.162A>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
fbiB 3640839 c.-696C>G upstream_gene_variant 0.38 clofazimine
pretomanid
delamanid
fbiA 3640850 p.Glu103Gly missense_variant 0.39 clofazimine
pretomanid
delamanid
fbiB 3640857 c.-678G>C upstream_gene_variant 0.33 clofazimine
pretomanid
delamanid
fbiB 3640863 c.-672C>T upstream_gene_variant 0.33 clofazimine
pretomanid
delamanid
fbiB 3640866 c.-669T>C upstream_gene_variant 0.32 clofazimine
pretomanid
delamanid
fbiA 3640871 p.Ala110Gly missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiB 3640878 c.-657T>C upstream_gene_variant 0.3 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3642662 c.1128C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3642668 c.1134A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642680 c.1146A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642695 c.1161G>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642719 c.1185T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
rpoA 3877513 p.Thr332Ser missense_variant 0.28 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.28 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.37 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.52 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.34 rifampicin
rpoA 3877704 c.804G>C synonymous_variant 0.35 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.29 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>G synonymous_variant 0.32 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.47 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.48 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.45 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Asn missense_variant 0.49 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.45 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.25 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.26 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.22 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.26 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.38 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.39 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.39 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.4 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.43 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.42 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.43 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.47 rifampicin