TB-Profiler result

Run: ERR323044
Summary

Run ID: ERR323044

Sample name:

Date: 2024-03-26T20:28:47.750426

Number of reads: 2007153

Percentage reads mapped: 39.32

Median coverage: 44.0

Strain: lineage4.3.4.2.1

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.97
lineage4 Euro-American None 0.96
lineage4.3.4.2.1 Euro-American (LAM) RD174 0.94
lineage4.3.4 Euro-American (LAM) RD174 0.97
lineage4.3.4.2 Euro-American (LAM) RD174 0.92
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ile335Thr Mutation from literature
ethambutol
pyrazinamide
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.838_840delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491620 c.838_840delATCinsGG frameshift_variant&missense_variant 0.24 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.19 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.24 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.23 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance Mutation from literature
amikacin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.58 kanamycin Assoc w R
amikacin Assoc w R
capreomycin Assoc w R
katG 2155108 p.Ile335Thr missense_variant 0.2 isoniazid Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 540 c.540C>G synonymous_variant 0.18 isoniazid
dnaA 543 c.543C>G synonymous_variant 0.18 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.3 isoniazid
dnaA 576 c.576G>C synonymous_variant 0.3 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 591 c.591C>G synonymous_variant 0.29 isoniazid
dnaA 600 c.600T>C synonymous_variant 0.29 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.26 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.26 isoniazid
dnaA 636 c.636C>G synonymous_variant 0.24 isoniazid
dnaA 645 c.645A>G synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.17 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.25 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.24 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.24 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.24 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.23 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.2 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.19 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.23 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.18 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.23 isoniazid
dnaA 1122 c.1122C>A synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 1125 c.1125G>C synonymous_variant 0.23 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.22 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.2 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.19 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.18 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 1177 p.Ala393Ser missense_variant 0.16 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.18 isoniazid
dnaA 1197 c.1197T>A synonymous_variant 0.17 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.17 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.16 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.21 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.29 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.33 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.31 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.3 isoniazid
dnaA 1293 c.1293T>G synonymous_variant 0.3 isoniazid
dnaA 1302 c.1302C>G synonymous_variant 0.29 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.19 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.19 isoniazid
dnaA 1431 c.1431A>G synonymous_variant 0.17 isoniazid
gyrB 6123 p.Ala295Gly missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6140 p.Val301Leu missense_variant 0.81 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6148 c.909C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6169 c.930C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6242 p.Arg335Asn missense_variant 0.14 levofloxacin
moxifloxacin
gyrB 6259 p.Asp340Glu missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6299 c.1060C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7457 c.156T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7862 c.561C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7919 p.Glu206Asp missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7923 p.His208Tyr missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9050 p.Asp583Glu missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9291 c.1990C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9666 p.Arg789Gly missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9674 c.2373T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9701 c.2400T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9704 c.2403T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9708 c.2407T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9722 c.2421C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9734 c.2433A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
Rv0010c 13631 c.-73T>A upstream_gene_variant 1.0 isoniazid
fgd1 490851 c.69A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491322 c.540G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491583 c.801G>A synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491595 c.813C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
mshA 575734 c.387T>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575767 c.420G>A synonymous_variant 0.23 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.22 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.19 ethionamide
isoniazid
ccsA 620340 c.450C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.27 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.2 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620622 c.732G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620625 c.735A>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
Rv0565c 657237 c.234A>G synonymous_variant 0.26 ethionamide
Rv0565c 657242 p.Glu77Lys missense_variant 0.25 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.28 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.28 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.28 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.27 ethionamide
Rv0565c 657291 c.180C>G synonymous_variant 0.17 ethionamide
Rv0565c 657300 c.171C>T synonymous_variant 0.17 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.17 ethionamide
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.18 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.19 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.19 ethionamide
Rv0565c 657656 c.-186C>T upstream_gene_variant 0.17 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.19 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.17 ethionamide
hadA 731747 c.-183T>C upstream_gene_variant 0.16 isoniazid
hadA 731753 c.-177A>G upstream_gene_variant 0.15 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.16 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.25 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.23 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.22 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.17 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.2 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.2 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.24 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.24 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.19 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.21 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.22 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.26 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734610 c.357C>G synonymous_variant 0.21 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.24 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.23 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.17 rifampicin
rpoB 760106 c.300G>T synonymous_variant 0.15 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.16 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.24 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760212 p.Asn136Tyr missense_variant 0.16 rifampicin
rpoB 760216 p.Asn137Thr missense_variant 0.16 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.25 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760276 p.Lys157Arg missense_variant 0.16 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.29 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.24 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.27 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.29 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.26 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.3 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.27 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.27 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.2 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.15 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.16 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.28 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.2 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.18 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.2 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.2 rifampicin
rpoB 760869 p.Val355Ile missense_variant 0.23 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.24 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.24 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.27 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.25 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.29 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.29 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761064 c.1258_1260delGCGinsTC frameshift_variant&missense_variant 0.22 rifampicin
rpoB 761084 c.1278C>G synonymous_variant 0.23 rifampicin
rpoB 761087 c.1281C>G synonymous_variant 0.23 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.36 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.37 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.27 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.24 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.24 rifampicin
rpoB 761213 c.1407G>A synonymous_variant 0.24 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.18 rifampicin
rpoB 761231 c.1425C>G synonymous_variant 0.18 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761301 c.1495C>A synonymous_variant 0.22 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.26 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.31 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.18 rifampicin
rpoB 761930 c.2124G>A synonymous_variant 0.2 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.27 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.25 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.26 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762057 p.Ile751Val missense_variant 0.25 rifampicin Uncertain significance
rpoB 762062 c.2256T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.31 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762084 p.Ala760Pro missense_variant 0.31 rifampicin
rpoB 762098 c.2292C>G synonymous_variant 0.31 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.5 rifampicin Uncertain significance
rpoB 762122 p.Asp772Glu missense_variant 0.47 rifampicin
rpoB 762128 c.2322G>C synonymous_variant 0.49 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.56 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.58 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762152 c.2346C>G synonymous_variant 0.48 rifampicin
rpoB 762161 c.2355C>G synonymous_variant 0.48 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762177 p.Arg791Gly missense_variant 0.46 rifampicin
rpoB 762181 p.Asp792Ala missense_variant 0.46 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762189 p.Ile795Val missense_variant 0.5 rifampicin
rpoB 762218 c.2412T>C synonymous_variant 0.51 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.41 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.53 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.4 rifampicin
rpoB 762293 c.2487T>G synonymous_variant 0.41 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.24 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.38 rifampicin
rpoC 762980 c.-390T>C upstream_gene_variant 0.27 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.26 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.46 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247_3249delTTGinsCC frameshift_variant&missense_variant 0.21 rifampicin
rpoC 763067 c.-303C>G upstream_gene_variant 0.23 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.22 rifampicin
rpoB 763077 p.Val1091Pro missense_variant 0.23 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763130 p.Glu1108Asp missense_variant 0.28 rifampicin
rpoB 763131 p.Pro1109Ser missense_variant 0.28 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.25 rifampicin
rpoB 763157 c.3351G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.17 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.36 rifampicin
rpoB 763170 p.Leu1122Met missense_variant 0.22 rifampicin
rpoC 763181 c.-189G>C upstream_gene_variant 0.18 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.25 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.29 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.31 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763462 c.93G>C synonymous_variant 0.16 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.29 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763504 c.135C>G synonymous_variant 0.39 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.4 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.57 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.48 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.49 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.53 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763550 p.Tyr61Asn missense_variant 0.58 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>G synonymous_variant 0.54 rifampicin
rpoC 763622 p.Ala85Ser missense_variant 0.56 rifampicin Uncertain significance
rpoC 763633 c.264T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763686 p.Tyr106Phe missense_variant 0.37 rifampicin
rpoC 763696 c.327T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.16 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.46 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.46 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.45 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.16 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.26 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.22 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.28 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.32 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.28 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.31 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.23 rifampicin
rpoC 763967 p.Gly200Ser missense_variant 0.17 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.19 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.25 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.23 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.24 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.24 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.26 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.25 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.22 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.18 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.21 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.25 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.26 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.24 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.24 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.44 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.27 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.46 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764470 c.1101C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764491 c.1122G>C synonymous_variant 0.32 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.32 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.56 rifampicin
rpoC 764507 p.Ala380Ser missense_variant 0.37 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.7 rifampicin
rpoC 764545 c.1176C>G synonymous_variant 0.59 rifampicin
rpoC 764548 c.1179G>C synonymous_variant 0.56 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.56 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsAC frameshift_variant&missense_variant 0.56 rifampicin
rpoC 764576 p.Ser403Thr missense_variant 0.14 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.71 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.55 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.52 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.64 rifampicin
rpoC 764706 p.Leu446Gln missense_variant 0.6 rifampicin Uncertain significance
rpoC 764716 c.1347G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764731 c.1362G>C synonymous_variant 0.45 rifampicin
rpoC 764737 c.1368G>C synonymous_variant 0.41 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.31 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764779 c.1410G>A synonymous_variant 0.21 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.16 rifampicin Not assoc w R
rpoC 764830 c.1461C>G synonymous_variant 0.16 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.19 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.98 rifampicin Not assoc w R
rpoC 765383 p.Met672Leu missense_variant 0.17 rifampicin Uncertain significance
rpoC 765421 c.2052C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.17 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.17 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765553 c.2184C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.18 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.18 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.17 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.15 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.22 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.22 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.24 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.25 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.26 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.18 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.18 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.29 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.23 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.23 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.31 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.31 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.31 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.23 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.24 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.22 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.2 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.17 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.17 rifampicin
rpoC 766327 c.2958C>G synonymous_variant 0.18 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.2 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.22 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.21 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.22 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.18 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.21 rifampicin
rpoC 766444 c.3075C>G synonymous_variant 0.22 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.23 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.28 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.29 rifampicin
rpoC 766489 c.3120G>T synonymous_variant 0.31 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.31 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.31 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.23 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.24 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.31 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.31 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.3 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.32 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.31 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.29 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.36 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.38 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.4 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.39 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.35 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.15 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.21 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.18 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766986 p.Val1206Glu missense_variant 0.19 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.32 rifampicin
rpoC 767017 c.3648C>G synonymous_variant 0.18 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.17 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.31 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.31 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.28 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.29 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.25 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.24 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.18 rifampicin
rpoC 767275 c.3906T>C synonymous_variant 0.2 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.19 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775937 c.2544G>C synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 776053 c.2428T>C synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 776056 p.Val809Leu missense_variant 0.17 clofazimine
bedaquiline
mmpL5 776076 p.Ala802Val missense_variant 0.18 clofazimine
bedaquiline
mmpL5 776665 p.Thr606Ala missense_variant 0.19 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776678 c.1803G>C synonymous_variant 0.19 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781608 c.49_51delAGTinsGC frameshift_variant&missense_variant 0.23 streptomycin Uncertain significance
rpsL 781631 c.72G>C synonymous_variant 0.23 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.31 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.3 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.23 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.19 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.2 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.2 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.29 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.28 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.18 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.27 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.2 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.2 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.21 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.21 streptomycin Uncertain significance
rplC 800537 c.-272C>T upstream_gene_variant 0.24 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.24 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.24 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.26 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.19 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.19 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.2 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.2 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.24 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.33 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.34 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.26 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.31 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.29 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.35 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.28 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.21 linezolid
rplC 800817 c.9A>T synonymous_variant 0.21 linezolid
rplC 800844 c.36T>C synonymous_variant 0.16 linezolid
rplC 801324 c.516T>C synonymous_variant 0.18 linezolid
rplC 801336 c.528C>G synonymous_variant 0.18 linezolid
rplC 801339 c.531T>C synonymous_variant 0.19 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.19 linezolid
rplC 801348 c.540T>G synonymous_variant 0.22 linezolid
rplC 801357 c.549T>C synonymous_variant 0.22 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.3 linezolid
rplC 801396 c.588T>C synonymous_variant 0.24 linezolid
rplC 801402 c.594T>C synonymous_variant 0.21 linezolid
rplC 801405 c.597T>C synonymous_variant 0.21 linezolid
rplC 801417 c.609T>C synonymous_variant 0.17 linezolid
fbiC 1303632 c.702T>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303701 c.771C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304991 c.2061G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305279 p.His783Gln missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305311 p.Arg794Gln missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
sigE 1364691 c.279T>C synonymous_variant 0.16 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.22 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.24 pyrazinamide
sigE 1364727 c.315C>T synonymous_variant 0.26 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.24 pyrazinamide
sigE 1364748 c.336G>C synonymous_variant 0.24 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.19 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.22 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.26 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.3 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.35 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.36 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.4 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.36 pyrazinamide
sigE 1364866 c.454_456delGCTinsTG frameshift_variant&missense_variant 0.36 pyrazinamide Uncertain significance
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.34 pyrazinamide Uncertain significance
sigE 1364904 p.Asp164Glu missense_variant 0.27 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472504 n.659A>T non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472574 n.729T>A non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472583 n.738T>C non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472674 n.829T>C non_coding_transcript_exon_variant 0.38 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472685 n.840G>A non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472701 n.856T>A non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473292 n.1447_1449delGGAinsTGGG non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1473788 n.131A>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473797 n.140G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473845 n.188G>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474292 n.635_648delTTCCTCTCCGGAGGinsAGC non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474483 n.826C>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474528 n.871T>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474529 n.872A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474540 n.883T>C non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474541 n.884G>T non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474630 n.973T>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474660 n.1003G>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474690 n.1033C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGCCAG non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475508 n.1851A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475752 n.2095_2098delCCGTinsGGG non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475757 n.2100A>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475759 n.2102C>G non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475768 n.2111_2112delGTinsC non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475776 n.2119G>C non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.71 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475990 n.2333G>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.72 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.65 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.64 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476668 n.3011C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673574 c.-628C>G upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674498 c.297G>A synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.31 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674588 c.387G>A synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.22 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.24 ethionamide
isoniazid
rpsA 1833568 c.27G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.28 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.3 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.42 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.46 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.29 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.41 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.25 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.16 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.34 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.46 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.43 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.56 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.48 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.48 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.53 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834129 c.588C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834210 c.669C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.48 pyrazinamide
rpsA 1834228 c.687C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.5 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.44 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834307 c.766_768delGACinsCG frameshift_variant&missense_variant 0.4 pyrazinamide Uncertain significance
rpsA 1834318 c.777C>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834340 c.799_801delATGinsTC frameshift_variant&missense_variant 0.29 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.26 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.18 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.19 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.19 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064912 c.-184A>G upstream_gene_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064936 c.-208C>A upstream_gene_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064945 c.-217G>A upstream_gene_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101960 c.1083A>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101966 c.1077T>G synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2101978 c.1063_1065delAACinsGT frameshift_variant&missense_variant 0.23 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2101988 p.Ala352Gly missense_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2102050 c.993T>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102053 c.990G>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102059 c.984T>C synonymous_variant 0.2 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102065 c.978G>C synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2102068 c.975T>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid
katG 2155029 c.1083C>G synonymous_variant 0.18 isoniazid
katG 2155032 c.1080T>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
katG 2155054 p.Tyr353Phe missense_variant 0.24 isoniazid
katG 2155056 c.1056A>G synonymous_variant 0.24 isoniazid
katG 2155062 c.1050T>C synonymous_variant 0.22 isoniazid
katG 2155065 c.1047C>G synonymous_variant 0.22 isoniazid
katG 2155068 c.1044T>C synonymous_variant 0.23 isoniazid
katG 2155071 c.1041T>C synonymous_variant 0.24 isoniazid
katG 2155080 c.1032G>C synonymous_variant 0.26 isoniazid
katG 2155113 c.999C>G synonymous_variant 0.19 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.18 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.17 isoniazid
katG 2155701 c.411C>T synonymous_variant 0.17 isoniazid Not assoc w R - Interim
katG 2155716 c.396T>C synonymous_variant 0.17 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.19 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.16 isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289991 c.-750G>C upstream_gene_variant 0.28 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.24 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.24 pyrazinamide
pncA 2290006 c.-765T>C upstream_gene_variant 0.26 pyrazinamide
pncA 2290009 c.-768A>G upstream_gene_variant 0.24 pyrazinamide
pncA 2290015 c.-774A>C upstream_gene_variant 0.22 pyrazinamide
kasA 2517947 c.-168C>T upstream_gene_variant 0.21 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.22 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.23 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.22 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.17 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.16 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.16 isoniazid
kasA 2518222 c.108G>A synonymous_variant 0.14 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.15 isoniazid
kasA 2518468 c.354A>T synonymous_variant 0.16 isoniazid
kasA 2518475 c.361A>C synonymous_variant 0.19 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.18 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.2 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.21 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.22 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.21 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.2 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.21 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.2 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.16 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.21 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.18 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.19 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.25 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.24 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.26 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.22 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.24 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.27 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.29 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.26 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.25 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.29 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.24 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.25 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.23 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.27 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.27 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.27 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.17 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.21 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.2 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.19 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.19 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.17 isoniazid
ahpC 2726687 c.495C>G synonymous_variant 0.18 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.18 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.18 isoniazid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783116 c.927T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 p.Thr301Met missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783578 p.Glu155Asp missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783860 p.Asp61Glu missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2752c 3065979 c.213T>C synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066744 c.-553C>G upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066747 c.-558_-556delCAAinsATC upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066756 c.-565G>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066765 c.-574G>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066771 c.-580C>G upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066798 c.-607G>T upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067355 c.591A>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067430 c.516C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067463 c.481_483delATCinsGA frameshift_variant&missense_variant 0.16 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067470 p.Asn159Ser missense_variant 0.18 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067500 p.Lys149Arg missense_variant 0.16 para-aminosalicylic_acid
thyX 3067682 c.264G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073868 p.Thr202Ala missense_variant 0.67 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.29 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073902 c.570C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.2 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 0.95 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0 pyrazinamide Not assoc w R
lpqB 3623528 c.1383G>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623531 c.1380T>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624077 c.834G>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624082 c.829A>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624401 c.510C>T synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624425 p.Glu162Ala missense_variant 0.19 bedaquiline
rifampicin
lpqB 3624428 c.483A>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624464 c.447A>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624470 c.441T>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624476 c.435C>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624482 c.429T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624485 p.Asp142Gly missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624491 c.420G>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624701 c.210T>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.16 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624725 c.186G>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.2 bedaquiline
rifampicin Uncertain significance
lpqB 3624760 c.151C>T synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624770 c.141T>C synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625285 c.-375G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.24 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.28 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.26 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.17 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.2 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.27 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625852 c.762A>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625888 c.-978G>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626795 c.-182C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>T upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627080 c.270T>C synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627170 c.-557C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.22 bedaquiline
rifampicin
mtrB 3627191 c.-578G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627197 c.-584T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627227 c.123T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCC frameshift_variant&missense_variant 0.18 bedaquiline
rifampicin
alr 3840719 c.702A>G synonymous_variant 0.97 cycloserine
rpoA 3877515 c.993G>C synonymous_variant 0.16 rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.2 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.23 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.22 rifampicin
rpoA 3877692 c.816G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877833 c.675C>G synonymous_variant 0.21 rifampicin
rpoA 3877836 c.672A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>C synonymous_variant 0.22 rifampicin
rpoA 3877845 c.663G>C synonymous_variant 0.23 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877878 c.630G>C synonymous_variant 0.34 rifampicin
rpoA 3877884 c.624G>C synonymous_variant 0.32 rifampicin
rpoA 3877905 c.601_603delTCAinsGG frameshift_variant&missense_variant 0.36 rifampicin
rpoA 3877908 p.Asn200Ala missense_variant 0.35 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877926 c.580_582delCTGinsGC frameshift_variant&missense_variant 0.28 rifampicin
rpoA 3877932 c.576G>C synonymous_variant 0.31 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877965 c.543C>G synonymous_variant 0.25 rifampicin
rpoA 3877968 c.540C>G synonymous_variant 0.25 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.26 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.26 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>C synonymous_variant 0.23 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.26 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.19 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.21 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.21 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.22 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.23 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.28 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.24 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.25 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.23 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.24 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.23 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.24 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.24 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.24 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.21 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.17 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.17 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.18 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.15 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.18 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.22 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.21 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.22 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.2 rifampicin
clpC1 4038278 c.2427T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038287 c.2418C>T synonymous_variant 0.78 pyrazinamide Not assoc w R
clpC1 4038293 c.2412G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAC frameshift_variant&missense_variant 0.24 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.21 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.17 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.17 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.16 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038611 c.2094C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.2 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.14 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039268 c.1437C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.22 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039338 p.Thr456Lys missense_variant 0.16 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039388 c.1317C>A synonymous_variant 0.18 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039424 c.1281G>A synonymous_variant 0.24 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.3 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.28 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039537 p.Ile390Val missense_variant 0.17 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039550 c.1155G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039559 c.1146C>A synonymous_variant 0.18 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039574 c.1129_1131delGCGinsTC frameshift_variant&missense_variant 0.2 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039733 c.972G>A synonymous_variant 0.17 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039773 p.Lys311Met missense_variant 0.29 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039817 c.888A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.4 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.32 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039838 c.865_867delCTGinsAC frameshift_variant&missense_variant 0.36 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039871 c.834C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039875 p.Asn277Arg missense_variant 0.33 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.42 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039943 c.760_762delTCGinsGC frameshift_variant&missense_variant 0.33 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.41 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.59 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.64 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.39 pyrazinamide
clpC1 4040000 p.His235Arg missense_variant 0.37 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040010 p.Ala232Asp missense_variant 0.4 pyrazinamide Uncertain significance
clpC1 4040018 c.687G>C synonymous_variant 0.37 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.5 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040057 c.648C>G synonymous_variant 0.47 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.39 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040117 c.588A>G synonymous_variant 0.45 pyrazinamide
clpC1 4040129 c.576C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040135 c.570C>G synonymous_variant 0.35 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040156 p.Met183Arg missense_variant 0.2 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040166 p.Ala180Gln missense_variant 0.22 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040315 p.Glu130Asp missense_variant 0.18 pyrazinamide
clpC1 4040324 c.381G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040331 p.Val125Asn missense_variant 0.28 pyrazinamide
clpC1 4040336 c.369G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.44 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.41 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040372 c.333C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.36 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.35 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.37 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>A synonymous_variant 0.2 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
panD 4043938 p.Ile115Thr missense_variant 0.94 pyrazinamide Uncertain significance
panD 4044737 c.-456T>C upstream_gene_variant 0.16 pyrazinamide
panD 4044781 c.-500C>T upstream_gene_variant 0.15 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.17 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.18 pyrazinamide
panD 4045025 c.-744C>G upstream_gene_variant 0.2 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.21 pyrazinamide
panD 4045034 c.-753A>T upstream_gene_variant 0.19 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.18 pyrazinamide
glpK 4138547 c.1209C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138568 c.1188A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138583 c.1173G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138586 c.1170C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138664 c.1092G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138667 c.1089G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139575 p.Val61Ile missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139581 p.Asn59Asp missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.157_159delGCCinsAG frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139630 c.126C>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139651 p.His35Gln missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240594 c.732C>G synonymous_variant 0.18 ethambutol
embC 4240600 c.738G>C synonymous_variant 0.17 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.17 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.17 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.19 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.18 ethambutol
embC 4240706 p.Val282Met missense_variant 0.15 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.22 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.22 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.21 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.3 ethambutol
embC 4240825 c.963G>A synonymous_variant 0.31 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.35 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.26 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.25 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.25 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.25 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.25 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.24 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.2 ethambutol
embC 4241035 c.1173G>A synonymous_variant 0.29 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.2 ethambutol
embC 4241086 c.1224G>C synonymous_variant 0.24 ethambutol
embC 4241137 c.1275G>C synonymous_variant 0.21 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.22 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.22 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.21 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.98 ethambutol Not assoc w R
embA 4245101 c.1869G>C synonymous_variant 0.2 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.3 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.32 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.33 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.28 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.25 ethambutol
embA 4245206 c.1974A>G synonymous_variant 0.2 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.2 ethambutol
embA 4245215 c.1983A>G synonymous_variant 0.21 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
embB 4247389 c.876C>A synonymous_variant 0.16 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.16 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.17 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.18 ethambutol
embB 4247779 c.1266C>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247785 c.1272G>C synonymous_variant 0.22 ethambutol
embB 4247800 c.1287A>C synonymous_variant 0.21 ethambutol
embB 4247806 c.1293G>C synonymous_variant 0.18 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.16 ethambutol
embB 4247824 c.1311C>G synonymous_variant 0.16 ethambutol
embB 4247830 c.1317A>C synonymous_variant 0.17 ethambutol
embB 4247836 c.1323A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4247842 c.1329T>C synonymous_variant 0.16 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.18 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.21 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.25 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.24 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.25 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.29 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.25 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.25 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.26 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.24 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.18 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.18 ethambutol
embB 4248298 c.1785C>T synonymous_variant 0.2 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.17 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.16 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.15 ethambutol
embB 4249456 c.2943G>C synonymous_variant 0.26 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.33 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.15 ethambutol
embB 4249564 c.3051C>T synonymous_variant 0.14 ethambutol
aftB 4267607 c.1230G>A synonymous_variant 0.19 ethambutol
aftB 4267619 c.1218C>G synonymous_variant 0.19 ethambutol
aftB 4267622 c.1215G>C synonymous_variant 0.17 ethambutol
aftB 4267625 c.1212T>C synonymous_variant 0.17 ethambutol
aftB 4267634 p.Arg401His missense_variant 0.18 ethambutol
aftB 4267637 c.1200C>G synonymous_variant 0.18 ethambutol
aftB 4267649 c.1188T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
ubiA 4269117 p.Glu239Asp missense_variant 0.15 ethambutol
aftB 4269123 c.-287T>C upstream_gene_variant 0.17 ethambutol
ubiA 4269141 c.691_693delTTGinsGC frameshift_variant&missense_variant 0.17 ethambutol
ubiA 4269144 c.690C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
ubiA 4269149 p.Val229Leu missense_variant 0.17 ethambutol Uncertain significance
aftB 4269183 c.-347T>C upstream_gene_variant 0.24 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.26 ethambutol
ubiA 4269209 p.Ser209Ala missense_variant 0.28 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.18 ethambutol
ubiA 4269222 c.612T>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
aftB 4269225 c.-389C>G upstream_gene_variant 0.18 ethambutol
aftB 4269231 c.-395C>G upstream_gene_variant 0.17 ethambutol
aftB 4269234 c.-398A>G upstream_gene_variant 0.17 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.17 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407839 p.Ser122Ala missense_variant 0.47 streptomycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R