TB-Profiler result

Run: ERR2514692
Summary

Run ID: ERR2514692

Sample name:

Date: 2024-05-22T16:02:37.511258

Number of reads: 1682215

Percentage reads mapped: 59.37

Median coverage: 49.0

Strain:

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.2.2 Indo-Oceanic RD239 0.98
lineage1.2.2.2 Indo-Oceanic RD239 0.96
La1.2.BCG M.bovis None 0.05
lineage6.2.3 West-Africa 2 RD702 0.07
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Ala356Val Uncertain significance Mutation from literature
p.Asn399Asp Mutation from literature
pyrazinamide
streptomycin rrs n.888G>A Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin tlyA c.4_6delGCAinsTT Assoc w R
kanamycin
cycloserine
ethionamide
clofazimine pepQ c.592_594delGCCinsCG Assoc w R - Interim
c.562_564delGTGinsAC Assoc w R - Interim
para-aminosalicylic_acid
delamanid fgd1 c.412_414delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.916_918delTTCinsGT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1945_1947delATTinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1963_1965delGGCinsAT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiB c.352_354delTTAinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1051_1053delATGinsGC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline pepQ c.592_594delGCCinsCG Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
c.562_564delGTGinsAC Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491194 c.412_414delCTAinsTG frameshift_variant&stop_gained 0.23 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.5 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303846 c.916_918delTTCinsGT frameshift_variant&missense_variant 0.48 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304875 c.1945_1947delATTinsGG frameshift_variant&missense_variant 0.44 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304893 c.1963_1965delGGCinsAT frameshift_variant&missense_variant 0.4 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.23 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance Mutation from literature
tlyA 1917943 c.4_6delGCAinsTT frameshift_variant&missense_variant 0.28 capreomycin Assoc w R
pepQ 2859825 c.592_594delGCCinsCG frameshift_variant&synonymous_variant 0.25 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
pepQ 2859855 c.562_564delGTGinsAC frameshift_variant&missense_variant 0.27 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
fbiB 3641886 c.352_354delTTAinsCG frameshift_variant&missense_variant 0.23 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiB 3642585 c.1051_1053delATGinsGC frameshift_variant&missense_variant 0.32 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247448 p.His312Arg missense_variant 0.39 ethambutol Mutation from literature
embB 4247580 p.Ala356Val missense_variant 0.21 ethambutol Uncertain significance Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.21 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.21 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.2 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.2 isoniazid
dnaA 771 c.771A>T synonymous_variant 0.2 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.2 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.2 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.2 isoniazid Uncertain significance
dnaA 813 c.813C>T synonymous_variant 0.19 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.19 isoniazid
dnaA 1062 c.1062C>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1068 c.1068T>C synonymous_variant 0.22 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.31 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.28 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.26 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.25 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.25 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.23 isoniazid
dnaA 1185 c.1185C>G synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1188 c.1188G>A synonymous_variant 0.2 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.2 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.19 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.19 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.26 isoniazid
dnaA 1375 c.1375T>C synonymous_variant 0.27 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.24 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.25 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.23 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.23 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.25 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.25 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.24 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.23 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.23 isoniazid
dnaA 1431 c.1431A>G synonymous_variant 0.22 isoniazid
dnaA 1440 c.1440C>T synonymous_variant 0.23 isoniazid
dnaA 1441 c.1441C>T synonymous_variant 0.23 isoniazid
dnaA 1461 c.1461C>G synonymous_variant 0.2 isoniazid
dnaA 1467 c.1467G>A synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1470 c.1470C>T synonymous_variant 0.18 isoniazid
gyrB 5075 c.-165C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6112 p.Met291Ile missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6178 c.939C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6181 c.942C>A synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6209 c.970C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.27 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6256 c.1017G>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6403 c.-899T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6778 c.-524C>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.3 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.34 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6853 c.-449A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6866 c.-436C>T upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642_1644delTTGinsCA frameshift_variant&missense_variant 0.32 levofloxacin Uncertain significance
moxifloxacin
gyrA 6892 c.-410C>T upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.28 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7108 c.-194G>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 7232 p.Arg665Cys missense_variant 0.89 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7442 c.141G>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.49 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7626 c.325C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8076 p.Val259Ile missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8096 c.795T>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8294 c.993T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8310 c.1009C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8318 c.1017C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8330 c.1029C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.22 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8400 c.1099_1101delGACinsAT frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8452 p.Ala384Val missense_variant 0.73 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8459 c.1158G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8528 c.1227G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8555 c.1254G>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8570 p.Glu423Asp missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8576 c.1275C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8666 c.1365G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin
gyrA 8767 p.Arg489Lys missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.38 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8882 c.1581G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.39 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.35 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9065 c.1764C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9146 c.1845C>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.42 levofloxacin
moxifloxacin
gyrA 9161 c.1860C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.53 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.53 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>G synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 9251 c.1950G>C synonymous_variant 0.51 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.51 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9263 c.1962C>T synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9284 c.1983T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9308 p.Asp669Glu missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9329 c.2028C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 0.98 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13699 c.-141A>G upstream_gene_variant 1.0 isoniazid Not assoc w R
fgd1 491106 c.324T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491142 c.360C>T synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491144 p.Ala121Asp missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491184 c.402A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Cys missense_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.25 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491289 c.507C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491292 c.510G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491296 p.Val172Ile missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491302 p.Ile174Val missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491307 c.525C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491313 c.531C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491325 c.543G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491331 c.549G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491340 c.558C>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491343 c.561C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491523 c.741G>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491583 c.801G>A synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491687 p.Thr302Lys missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491697 c.915G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 574607 c.-741G>C upstream_gene_variant 0.36 ethionamide
isoniazid
mshA 574616 c.-732G>T upstream_gene_variant 0.43 ethionamide
isoniazid
mshA 574619 c.-729C>G upstream_gene_variant 0.43 ethionamide
isoniazid
mshA 574625 c.-723C>G upstream_gene_variant 0.44 ethionamide
isoniazid
mshA 574650 c.-698A>C upstream_gene_variant 0.42 ethionamide
isoniazid
mshA 574655 c.-693C>G upstream_gene_variant 0.45 ethionamide
isoniazid
mshA 574667 c.-681G>A upstream_gene_variant 0.38 ethionamide
isoniazid
mshA 574671 c.-677_-675delGCAinsCTG upstream_gene_variant 0.39 ethionamide
isoniazid
mshA 574676 c.-672G>C upstream_gene_variant 0.4 ethionamide
isoniazid
mshA 574683 c.-665T>C upstream_gene_variant 0.35 ethionamide
isoniazid Uncertain significance
mshA 574692 c.-656_-654delCTCinsTG upstream_gene_variant 0.38 ethionamide
isoniazid
mshA 574712 c.-636A>G upstream_gene_variant 0.38 ethionamide
isoniazid
mshA 574718 c.-630A>G upstream_gene_variant 0.33 ethionamide
isoniazid
mshA 575075 c.-273T>C upstream_gene_variant 0.19 ethionamide
isoniazid Uncertain significance
mshA 575078 c.-270C>G upstream_gene_variant 0.21 ethionamide
isoniazid
mshA 575090 c.-258G>A upstream_gene_variant 0.19 ethionamide
isoniazid
mshA 575649 p.Val101Ala missense_variant 0.33 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.31 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.35 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>G synonymous_variant 0.37 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.41 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.37 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.38 ethionamide
isoniazid
mshA 575749 c.402C>G synonymous_variant 0.37 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.36 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.38 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.38 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.38 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.38 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.39 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.37 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.33 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575909 c.562C>T synonymous_variant 0.29 ethionamide
isoniazid
mshA 575917 p.Asp190Glu missense_variant 0.27 ethionamide
isoniazid
mshA 575920 c.573C>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575924 p.Gly193Ser missense_variant 0.26 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575950 c.603C>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575965 c.618C>G synonymous_variant 0.25 ethionamide
isoniazid Not assoc w R - Interim
mshA 575980 c.633T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575983 c.636G>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575984 c.637T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 576004 c.657T>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 576007 c.660A>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 576017 p.Val224Leu missense_variant 0.22 ethionamide
isoniazid
mshA 576026 p.Leu227Ile missense_variant 0.19 ethionamide
isoniazid
ccsA 619507 c.-384A>G upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619528 c.-363C>G upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356_-354delCAAinsGCG upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619543 c.-348C>G upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619564 c.-327C>G upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619572 c.-319T>A upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619594 c.-297G>C upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>C upstream_gene_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 619615 c.-276C>T upstream_gene_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>G upstream_gene_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620169 c.279G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620173 c.283_285delGTCinsCG frameshift_variant&missense_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620196 c.306C>G synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620197 p.Gln103Val missense_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620226 c.336G>A synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620277 c.387G>A synonymous_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620284 c.394_396delGCGinsCC frameshift_variant&missense_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.44 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.37 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.3 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620442 c.552G>C synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620460 c.570T>G synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620461 p.Val191Ile missense_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620481 c.591T>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620583 c.693G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620598 c.708C>G synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>T synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620622 c.732G>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620625 c.735A>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620659 c.769_771delCGCinsAG frameshift_variant&missense_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620664 c.774C>T synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAT frameshift_variant&missense_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.36 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>G synonymous_variant 0.53 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>G synonymous_variant 0.56 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>G synonymous_variant 0.55 capreomycin
amikacin
kanamycin
ccsA 620796 c.906C>G synonymous_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620809 c.919C>T synonymous_variant 0.45 capreomycin
amikacin
kanamycin
ccsA 620823 c.933C>T synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620832 c.942C>T synonymous_variant 0.25 capreomycin
amikacin
kanamycin
Rv0565c 656192 p.Asp427Asn missense_variant 0.26 ethionamide Uncertain significance
Rv0565c 656219 p.His418Tyr missense_variant 0.31 ethionamide
Rv0565c 656220 c.1251A>C synonymous_variant 0.31 ethionamide
Rv0565c 656223 c.1248T>C synonymous_variant 0.32 ethionamide Not assoc w R - Interim
Rv0565c 656226 c.1243_1245delGCCinsTT frameshift_variant&missense_variant 0.32 ethionamide Uncertain significance
Rv0565c 656238 p.Ala411Glu missense_variant 0.35 ethionamide
Rv0565c 656243 p.Leu410Met missense_variant 0.36 ethionamide
Rv0565c 656244 c.1227A>C synonymous_variant 0.36 ethionamide
Rv0565c 656265 c.1206G>C synonymous_variant 0.35 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.35 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.35 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.33 ethionamide
Rv0565c 656298 c.1173G>C synonymous_variant 0.3 ethionamide
Rv0565c 656304 c.1167T>C synonymous_variant 0.26 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.18 ethionamide Uncertain significance
Rv0565c 657372 c.99G>C synonymous_variant 0.18 ethionamide
Rv0565c 657375 c.96C>T synonymous_variant 0.18 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.2 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.24 isoniazid
hadA 731687 c.-243_-242insCACCAGATCTTTT upstream_gene_variant 0.21 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.21 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.22 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.22 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.22 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.22 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.29 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.29 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.28 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.3 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.25 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.18 isoniazid
hadA 732226 c.297G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
hadA 732270 p.Glu114Val missense_variant 0.17 isoniazid
hadA 732272 p.Ala115Ser missense_variant 0.17 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.23 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.2 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.21 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.21 isoniazid
hadA 732319 p.Glu130Asp missense_variant 0.2 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.2 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.21 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.22 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.26 isoniazid
hadA 732373 c.444G>A synonymous_variant 0.28 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.26 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.29 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.29 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.28 isoniazid
nusG 734116 c.-138T>C upstream_gene_variant 0.83 rifampicin Not assoc w R
nusG 734403 c.150C>T synonymous_variant 0.3 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.31 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.29 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.25 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.34 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.34 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.33 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.36 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.43 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
nusG 734547 c.294G>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.41 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.41 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.37 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.38 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.38 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.35 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.21 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.31 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.26 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.27 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.26 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.26 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.31 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.31 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.29 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.3 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760519 p.Thr238Ser missense_variant 0.34 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.34 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.35 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.29 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.37 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.38 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.39 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.39 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.35 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.36 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.37 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.34 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.34 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.35 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.35 rifampicin
rpoB 760808 c.1002C>G synonymous_variant 0.35 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.34 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760845 c.1039_1041delACCinsCG frameshift_variant&missense_variant 0.29 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.28 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.3 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.37 rifampicin
rpoB 760910 c.1104C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.46 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.46 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.47 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.42 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761042 c.1236C>T synonymous_variant 0.36 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.35 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.41 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.42 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.42 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.23 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.24 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.26 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.26 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.23 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761420 c.1614C>G synonymous_variant 0.24 rifampicin
rpoB 761423 c.1617T>C synonymous_variant 0.24 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.2 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.18 rifampicin
rpoB 761615 c.1809A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761834 c.2028T>C synonymous_variant 0.21 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.22 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.24 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.26 rifampicin
rpoB 761867 c.2061C>T synonymous_variant 0.27 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.29 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.33 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.31 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.32 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.32 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.32 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.52 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.45 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762050 c.2244G>A synonymous_variant 0.42 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.36 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.38 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.39 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.38 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.45 rifampicin
rpoB 762221 c.2415G>A synonymous_variant 0.44 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.33 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.32 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762299 c.2493G>C synonymous_variant 0.32 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762323 c.2517C>G synonymous_variant 0.24 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.2 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.2 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.24 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.26 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.28 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.28 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.32 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.34 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.29 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.23 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.19 rifampicin Uncertain significance
rpoC 762537 c.-833T>C upstream_gene_variant 0.2 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.3 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.29 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.3 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.63 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.48 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763145 c.3339G>A synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.55 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.6 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763193 c.3387C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>C upstream_gene_variant 0.41 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.37 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.37 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.35 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.25 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.24 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>A synonymous_variant 0.19 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.19 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.31 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.45 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.48 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.46 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.35 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.35 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.34 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.33 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.33 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.33 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.2 rifampicin
rpoC 763853 c.484_486delGTCinsAT frameshift_variant&missense_variant 0.29 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.29 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.29 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.26 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.28 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.69 rifampicin Not assoc w R
rpoC 763886 c.517_519delCGGinsAC frameshift_variant&missense_variant 0.67 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.32 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.23 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.24 rifampicin
rpoC 763942 c.573C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.25 rifampicin
rpoC 763948 c.579G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763954 c.585C>G synonymous_variant 0.26 rifampicin
rpoC 763963 c.594C>G synonymous_variant 0.26 rifampicin
rpoC 763969 c.600C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.22 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.19 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.26 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.28 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.29 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.33 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.38 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.43 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.44 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.45 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764237 p.Leu290Ile missense_variant 0.44 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.43 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.43 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.4 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.41 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.27 rifampicin
rpoC 764329 c.960C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.41 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.46 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.46 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.44 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.57 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.55 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.51 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1209delTCCinsAGT synonymous_variant 0.47 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.62 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.4 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>C synonymous_variant 0.39 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.33 rifampicin
rpoC 764896 c.1527C>T synonymous_variant 0.33 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765371 c.2002C>T synonymous_variant 0.3 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.35 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.38 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.37 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765454 c.2085C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.33 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.37 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.38 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.38 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.35 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.36 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.4 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.39 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.4 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.39 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.38 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.35 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.33 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.41 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.41 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.33 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.29 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.33 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.38 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.41 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.43 rifampicin
rpoC 766081 c.2712T>C synonymous_variant 0.37 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.36 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.36 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.27 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.22 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766280 p.Ser971Gly missense_variant 0.24 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.28 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.46 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.49 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.6 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.62 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.65 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.65 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.62 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.64 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.61 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.62 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.63 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.57 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.47 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.47 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.47 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.45 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.48 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.48 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.46 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.49 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.54 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.59 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.6 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.6 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.58 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.61 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.63 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.55 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.52 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.5 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.54 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.54 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.58 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.6 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.53 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.54 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.54 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.56 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.49 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766966 c.3597G>A synonymous_variant 0.46 rifampicin
rpoC 766972 c.3603G>C synonymous_variant 0.46 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.48 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.51 rifampicin
rpoC 767149 c.3780C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.48 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.35 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767265 p.Ala1299Glu missense_variant 0.16 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775966 p.Ala839Ser missense_variant 0.19 clofazimine
bedaquiline
mmpL5 775975 c.2506T>C synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.2 clofazimine
bedaquiline
mmpL5 775997 c.2484T>C synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 776000 c.2481G>C synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777133 p.Val450Ile missense_variant 0.25 clofazimine
bedaquiline
mmpL5 777158 c.1323C>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 777170 c.1311T>C synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 777173 c.1308C>G synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.24 clofazimine
bedaquiline
mmpL5 777191 c.1290C>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 777194 c.1287A>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 777206 c.1275A>G synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 777212 c.1267_1269delGCCinsAG frameshift_variant&missense_variant 0.29 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 777215 c.1266C>G synonymous_variant 0.3 clofazimine
bedaquiline
mmpL5 777218 c.1263G>A synonymous_variant 0.3 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.23 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.23 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.23 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.33 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.33 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.4 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.4 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.4 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.42 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.46 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.44 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.41 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.42 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.43 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.48 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.48 streptomycin
rpsL 781769 c.210G>A synonymous_variant 0.44 streptomycin
rpsL 781772 c.213C>G synonymous_variant 0.44 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.37 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.4 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.4 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.44 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.42 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.4 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.38 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.38 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.4 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.37 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.38 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.32 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.31 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 0.98 linezolid Not assoc w R
rplC 800546 c.-263T>G upstream_gene_variant 0.23 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.28 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.29 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.35 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.39 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.41 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.39 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.43 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.4 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.42 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.42 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.4 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.41 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.37 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.38 linezolid
rplC 800783 c.-26C>T upstream_gene_variant 0.3 linezolid
rplC 800794 c.-15_-9delAGATTGGinsGAGTT upstream_gene_variant 0.25 linezolid
rplC 800814 c.6A>G synonymous_variant 0.29 linezolid
rplC 800817 c.9A>T synonymous_variant 0.3 linezolid
rplC 800844 c.36T>C synonymous_variant 0.23 linezolid
rplC 800865 c.57A>G synonymous_variant 0.22 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.22 linezolid
rplC 800874 c.66A>G synonymous_variant 0.19 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.19 linezolid
rplC 800880 c.72A>G synonymous_variant 0.2 linezolid
rplC 800889 c.81C>G synonymous_variant 0.22 linezolid
rplC 800892 c.84G>C synonymous_variant 0.23 linezolid
rplC 800907 c.99C>G synonymous_variant 0.25 linezolid
rplC 800916 c.108A>G synonymous_variant 0.24 linezolid
rplC 800934 c.126C>G synonymous_variant 0.27 linezolid
rplC 800937 c.129A>G synonymous_variant 0.27 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.27 linezolid
rplC 800946 c.138T>C synonymous_variant 0.28 linezolid
rplC 800949 c.141T>C synonymous_variant 0.27 linezolid
rplC 800967 c.159C>G synonymous_variant 0.26 linezolid
rplC 800970 c.162T>C synonymous_variant 0.26 linezolid Not assoc w R - Interim
rplC 800982 c.174C>T synonymous_variant 0.25 linezolid
rplC 801246 c.438C>T synonymous_variant 0.3 linezolid
rplC 801249 c.441T>C synonymous_variant 0.32 linezolid
rplC 801255 c.447C>T synonymous_variant 0.32 linezolid
rplC 801264 c.456C>T synonymous_variant 0.32 linezolid
rplC 801267 c.459A>T synonymous_variant 0.33 linezolid
rplC 801270 c.462T>C synonymous_variant 0.33 linezolid
rplC 801276 c.468G>C synonymous_variant 0.3 linezolid
rplC 801279 c.471G>C synonymous_variant 0.29 linezolid
rplC 801282 c.474G>C synonymous_variant 0.27 linezolid
rplC 801285 c.477G>C synonymous_variant 0.27 linezolid
rplC 801309 c.501C>G synonymous_variant 0.3 linezolid
rplC 801312 c.504G>C synonymous_variant 0.28 linezolid
rplC 801321 c.513C>T synonymous_variant 0.3 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.32 linezolid
rplC 801339 c.531T>C synonymous_variant 0.29 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.29 linezolid
rplC 801348 c.540T>G synonymous_variant 0.27 linezolid
rplC 801357 c.549T>C synonymous_variant 0.3 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.26 linezolid
rplC 801402 c.594T>C synonymous_variant 0.3 linezolid
rplC 801405 c.597T>C synonymous_variant 0.31 linezolid
rplC 801423 c.615G>C synonymous_variant 0.48 linezolid
rplC 801426 c.618C>G synonymous_variant 0.5 linezolid
rplC 801427 p.Met207Val missense_variant 0.47 linezolid
rplC 801438 c.630T>C synonymous_variant 0.48 linezolid
rplC 801442 p.Ile212Val missense_variant 0.54 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303455 c.525C>G synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303464 c.534A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303476 c.546G>C synonymous_variant 0.3 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303480 p.Gln184Glu missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303489 c.559C>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303501 c.571C>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303530 c.600G>A synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303654 c.724C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303663 c.733C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303677 c.747C>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Glu missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.48 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>T synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303812 c.882C>T synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304050 c.1120T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304085 c.1155C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304091 p.Asp387Glu missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304104 c.1174C>T synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304115 c.1185A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304499 c.1569T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304535 c.1605G>A synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304541 c.1611C>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304625 c.1695C>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.5 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304760 c.1830G>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>T synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.73 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.73 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.88 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304889 c.1959G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304896 c.1966C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304904 c.1974G>A synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1304991 c.2061G>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.54 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305016 p.Thr696Ala missense_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1305051 c.2121G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305096 c.2166T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305114 c.2184T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>C synonymous_variant 0.27 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305135 c.2205C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305150 c.2220C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
sigE 1364886 c.474G>A synonymous_variant 0.27 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.27 pyrazinamide Uncertain significance
sigE 1364904 p.Asp164Glu missense_variant 0.23 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.21 pyrazinamide
sigE 1364949 c.537C>T synonymous_variant 0.27 pyrazinamide
sigE 1364950 p.Ala180Ser missense_variant 0.27 pyrazinamide
sigE 1364958 c.546G>C synonymous_variant 0.26 pyrazinamide
sigE 1364961 c.549A>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472647 n.802C>T non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472707 n.862A>T non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.63 streptomycin Not assoc w R
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTT non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473293 n.1449A>G non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473676 n.20dupC non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.56 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.43 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
inhA 1673556 c.-646C>G upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673568 c.-634C>A upstream_gene_variant 0.25 ethionamide
isoniazid
fabG1 1673569 p.Val44Ile missense_variant 0.27 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.27 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.31 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>G upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1673595 c.-607A>C upstream_gene_variant 0.35 ethionamide
isoniazid
fabG1 1673596 p.Lys53Glu missense_variant 0.35 ethionamide
isoniazid
inhA 1673602 c.-600C>T upstream_gene_variant 0.38 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.35 ethionamide
isoniazid
fabG1 1673615 p.Glu59Val missense_variant 0.35 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.33 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.32 ethionamide
isoniazid
fabG1 1673637 p.Asp66Glu missense_variant 0.3 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.35 ethionamide
isoniazid
inhA 1673652 c.-550C>G upstream_gene_variant 0.35 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.35 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.35 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.33 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.32 ethionamide
isoniazid
inhA 1673679 c.-523T>C upstream_gene_variant 0.33 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673703 c.-499C>T upstream_gene_variant 0.33 ethionamide
isoniazid
fabG1 1673710 p.Leu91Ile missense_variant 0.31 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.29 ethionamide
isoniazid
inhA 1673721 c.-481C>T upstream_gene_variant 0.28 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.27 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.32 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.27 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.31 ethionamide
isoniazid
inhA 1673781 c.-421C>G upstream_gene_variant 0.25 ethionamide
isoniazid
fabG1 1673890 p.Ala151Ser missense_variant 0.16 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.2 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.36 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.33 ethionamide
isoniazid
inhA 1674018 c.-184G>C upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1674019 c.-183C>T upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1674030 c.-172G>C upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1674033 c.-169T>C upstream_gene_variant 0.26 ethionamide
isoniazid
fabG1 1674037 p.Gln200Glu missense_variant 0.26 ethionamide
isoniazid
inhA 1674042 c.-160G>T upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1674049 c.610_612delCAAinsGC frameshift_variant&missense_variant 0.24 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.24 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.24 ethionamide
isoniazid
inhA 1674063 c.-139G>C upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.19 ethionamide
isoniazid
inhA 1674471 c.270G>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674504 c.303C>G synonymous_variant 0.41 ethionamide
isoniazid
inhA 1674507 c.306G>A synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674514 p.Ile105Val missense_variant 0.47 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.55 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674552 c.351C>G synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.51 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.56 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.6 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.61 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.62 ethionamide
isoniazid
inhA 1674601 p.Leu134Ala missense_variant 0.53 ethionamide
isoniazid
inhA 1674609 c.408G>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674621 c.420C>G synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674624 c.423A>T synonymous_variant 0.46 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.44 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674723 c.522C>T synonymous_variant 0.36 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674726 c.525G>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674732 c.531C>T synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674746 p.Tyr182Phe missense_variant 0.31 ethionamide
isoniazid
inhA 1674750 c.549T>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.28 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674813 c.612C>T synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674816 c.615T>C synonymous_variant 0.32 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674840 c.639C>G synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.34 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.26 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674960 c.759C>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674965 c.765delT frameshift_variant 0.21 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.37 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.34 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.32 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.39 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.58 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.56 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.56 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.63 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.63 pyrazinamide
rpsA 1833799 c.258C>T synonymous_variant 0.62 pyrazinamide
rpsA 1833805 c.264C>G synonymous_variant 0.62 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.61 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.54 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.54 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.57 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.57 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.52 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.53 pyrazinamide
rpsA 1833931 c.390C>T synonymous_variant 0.59 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.56 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.57 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.58 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.55 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.51 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.39 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.25 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.28 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834303 c.762T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>T synonymous_variant 0.41 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.42 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.58 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.59 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.61 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.57 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.47 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.45 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.43 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.4 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.34 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.51 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.45 linezolid
tsnR 1853375 c.-231G>C upstream_gene_variant 0.43 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.39 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.39 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.28 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.26 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.26 linezolid
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917908 c.-32C>G upstream_gene_variant 0.2 capreomycin
tlyA 1917925 c.-15A>G upstream_gene_variant 0.25 capreomycin
tlyA 1917929 c.-11T>C upstream_gene_variant 0.26 capreomycin
tlyA 1917937 c.-3_-2insC upstream_gene_variant 0.28 capreomycin
tlyA 1917940 p.Val1Met missense_variant 0.28 capreomycin
tlyA 1917951 c.12T>C synonymous_variant 0.31 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917975 c.36C>G synonymous_variant 0.38 capreomycin
tlyA 1917981 c.42G>C synonymous_variant 0.44 capreomycin
tlyA 1917990 c.51G>C synonymous_variant 0.61 capreomycin
tlyA 1917993 c.54A>G synonymous_variant 0.64 capreomycin Not assoc w R - Interim
tlyA 1917996 c.57A>G synonymous_variant 0.61 capreomycin
tlyA 1918002 c.63A>G synonymous_variant 0.61 capreomycin
tlyA 1918022 p.Gly28Asp missense_variant 0.74 capreomycin
tlyA 1918035 c.96G>C synonymous_variant 0.57 capreomycin
tlyA 1918036 p.Arg33Ser missense_variant 0.6 capreomycin
tlyA 1918048 p.Leu37Met missense_variant 0.53 capreomycin
tlyA 1918053 c.114G>C synonymous_variant 0.47 capreomycin
tlyA 1918057 p.Val40Arg missense_variant 0.44 capreomycin
tlyA 1918065 c.126G>C synonymous_variant 0.39 capreomycin
tlyA 1918067 p.Ala43Gly missense_variant 0.3 capreomycin
tlyA 1918077 c.138G>C synonymous_variant 0.31 capreomycin
tlyA 1918078 p.Ser47Ala missense_variant 0.31 capreomycin
tlyA 1918082 p.Asp48Val missense_variant 0.31 capreomycin
tlyA 1918087 p.Thr50Ala missense_variant 0.31 capreomycin
tlyA 1918092 c.153G>C synonymous_variant 0.3 capreomycin
tlyA 1918104 c.165G>C synonymous_variant 0.21 capreomycin
tlyA 1918362 c.423G>C synonymous_variant 0.2 capreomycin
tlyA 1918377 c.438T>G synonymous_variant 0.22 capreomycin
tlyA 1918379 p.Arg147Pro missense_variant 0.22 capreomycin
tlyA 1918382 p.Val148Ala missense_variant 0.25 capreomycin
tlyA 1918389 c.450G>C synonymous_variant 0.26 capreomycin
tlyA 1918392 c.453A>C synonymous_variant 0.26 capreomycin
tlyA 1918417 c.478T>C synonymous_variant 0.22 capreomycin
tlyA 1918422 c.483T>C synonymous_variant 0.22 capreomycin
tlyA 1918425 c.486C>G synonymous_variant 0.21 capreomycin Not assoc w R - Interim
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2064972 c.-244T>C upstream_gene_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155641 p.Lys157Asn missense_variant 0.2 isoniazid Uncertain significance
katG 2155661 p.Val151Ile missense_variant 0.22 isoniazid
katG 2155668 c.444G>C synonymous_variant 0.23 isoniazid
katG 2155677 c.435C>A synonymous_variant 0.28 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.28 isoniazid
katG 2155686 c.426C>T synonymous_variant 0.28 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.29 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.33 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.31 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.32 isoniazid
katG 2155728 c.384G>T synonymous_variant 0.29 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.33 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.32 isoniazid
katG 2155767 c.345C>T synonymous_variant 0.35 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168742 p.Gly624Asp missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223553 c.-389C>A upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Uncertain significance
pncA 2289916 c.-675A>G upstream_gene_variant 0.23 pyrazinamide
pncA 2289925 c.-684T>C upstream_gene_variant 0.24 pyrazinamide
pncA 2289930 c.-689A>G upstream_gene_variant 0.22 pyrazinamide
pncA 2289940 c.-699C>G upstream_gene_variant 0.23 pyrazinamide
pncA 2289943 c.-704_-702delTTTinsCG upstream_gene_variant 0.23 pyrazinamide
pncA 2289948 c.-707C>T upstream_gene_variant 0.23 pyrazinamide
pncA 2289949 c.-708A>G upstream_gene_variant 0.23 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.25 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.25 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.25 pyrazinamide
pncA 2290009 c.-768A>G upstream_gene_variant 0.21 pyrazinamide
kasA 2517923 c.-192C>G upstream_gene_variant 0.34 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.25 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.32 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.34 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.29 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.24 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.21 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.24 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.24 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.28 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.29 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.32 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.3 isoniazid
kasA 2518564 c.450C>G synonymous_variant 0.29 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.29 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.29 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.27 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.33 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.31 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.33 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.31 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.25 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.29 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.28 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.21 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.26 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.29 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.31 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.3 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.29 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.39 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.39 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.36 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.33 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.33 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.32 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.44 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.46 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.44 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.34 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.34 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.33 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.32 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.32 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.31 isoniazid
kasA 2518915 c.801T>C synonymous_variant 0.26 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.26 isoniazid
kasA 2518927 c.813C>G synonymous_variant 0.26 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.22 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.21 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.21 isoniazid
kasA 2519095 c.981C>G synonymous_variant 0.21 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.23 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.23 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.26 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.26 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.24 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.25 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.21 isoniazid
kasA 2519170 c.1056G>T synonymous_variant 0.21 isoniazid
kasA 2519206 c.1092C>T synonymous_variant 0.19 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0 isoniazid
folC 2747023 c.576C>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747032 c.567A>G synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747053 c.546C>T synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747059 c.540T>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747071 c.528C>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747083 c.516G>A synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747086 c.513A>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747089 c.510G>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747264 p.Gly112Ala missense_variant 0.33 para-aminosalicylic_acid
folC 2747266 c.333C>T synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747281 c.318A>G synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747284 c.315G>C synonymous_variant 0.33 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.32 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.32 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.31 para-aminosalicylic_acid
folC 2747299 c.300C>T synonymous_variant 0.34 para-aminosalicylic_acid
folC 2747302 c.297A>C synonymous_variant 0.4 para-aminosalicylic_acid
folC 2747314 c.285A>G synonymous_variant 0.41 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.42 para-aminosalicylic_acid
folC 2747329 c.270C>T synonymous_variant 0.48 para-aminosalicylic_acid
folC 2747332 c.267G>A synonymous_variant 0.48 para-aminosalicylic_acid
folC 2747338 c.261C>G synonymous_variant 0.47 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.47 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.44 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.45 para-aminosalicylic_acid
folC 2747368 c.231G>A synonymous_variant 0.48 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.28 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.3 para-aminosalicylic_acid
folC 2747407 c.192T>C synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747411 p.Ser63Ala missense_variant 0.19 para-aminosalicylic_acid
folC 2747419 c.180C>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747422 c.177G>A synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747430 c.169C>T synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747442 c.157T>C synonymous_variant 0.2 para-aminosalicylic_acid
Rv2477c 2783015 p.Ser343Thr missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783048 p.Asp332Gly missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783053 c.990C>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.4 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783287 c.756C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 p.Leu182Phe missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783521 c.522G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783566 p.Asn159Lys missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783673 c.370C>A synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.48 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783695 c.348C>T synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783716 c.327G>A synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783853 c.190C>T synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784390 c.-348G>C upstream_gene_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784435 c.-393C>G upstream_gene_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784441 c.-399G>C upstream_gene_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784452 c.-410C>T upstream_gene_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784454 c.-412G>A upstream_gene_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784494 c.-452C>G upstream_gene_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784501 c.-459T>C upstream_gene_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784510 c.-470_-468delAGCinsGCT upstream_gene_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784513 c.-471C>G upstream_gene_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859804 c.615C>T synonymous_variant 0.17 clofazimine
bedaquiline
pepQ 2859807 c.612C>T synonymous_variant 0.18 clofazimine
bedaquiline
pepQ 2859822 c.597T>C synonymous_variant 0.24 clofazimine
bedaquiline
pepQ 2859831 c.588C>G synonymous_variant 0.24 clofazimine
bedaquiline
pepQ 2859834 c.585T>C synonymous_variant 0.26 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
pepQ 2859843 c.576G>C synonymous_variant 0.28 clofazimine
bedaquiline
pepQ 2859852 c.567A>G synonymous_variant 0.27 clofazimine
bedaquiline
pepQ 2859859 p.Ala187Gly missense_variant 0.27 clofazimine
bedaquiline
pepQ 2859864 c.555T>C synonymous_variant 0.29 clofazimine
bedaquiline
pepQ 2859870 c.549T>C synonymous_variant 0.32 clofazimine
bedaquiline
pepQ 2859897 c.522C>G synonymous_variant 0.33 clofazimine
bedaquiline
pepQ 2859903 c.516G>C synonymous_variant 0.33 clofazimine
bedaquiline
Rv2681 2997060 p.Asn108Asp missense_variant 0.26 capreomycin
Rv2681 2997065 c.327G>A synonymous_variant 0.24 capreomycin
Rv2681 2997092 c.354T>C synonymous_variant 0.2 capreomycin
Rv2681 2997291 c.553T>C synonymous_variant 0.22 capreomycin
Rv2752c 3064791 c.1401T>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064797 c.1395G>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064803 c.1389C>T synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064809 c.1383C>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064815 c.1377T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064831 p.Ala454Asn missense_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064838 c.1354T>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064860 c.1332G>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064872 c.1320T>G synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064877 p.Ser439Ala missense_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064878 c.1314C>A synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064881 p.Ser437Ala missense_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064887 c.1303_1305delAAAinsGG frameshift_variant&missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064893 c.1299C>G synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064896 c.1296T>C synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064914 c.1278T>G synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064926 c.1264_1266delTTGinsCC frameshift_variant&missense_variant 0.36 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064932 c.1260T>C synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064941 c.1249_1251delCAAinsGG frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064947 c.1245A>G synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064950 c.1242C>G synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064956 c.1234_1236delAGTinsCC frameshift_variant&missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064962 c.1230C>G synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064973 p.Ala407Ser missense_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064974 c.1218T>C synonymous_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064995 c.1197C>G synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064998 c.1194A>G synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065007 c.1185G>C synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065013 c.1179G>C synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065018 p.Asn392His missense_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065022 c.1170G>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065040 c.1152C>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065048 c.1144C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066513 c.-322C>G upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066537 c.-346C>T upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066583 c.-392C>G upstream_gene_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066612 c.-421G>A upstream_gene_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066617 c.-426G>A upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066618 c.-427A>C upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066633 c.-442T>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066855 c.-664T>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066969 c.-778G>C upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067281 p.Val222Ala missense_variant 0.21 para-aminosalicylic_acid
thyX 3067284 p.Ala221Ser missense_variant 0.21 para-aminosalicylic_acid
thyX 3067286 c.660C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067292 c.654G>A synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067295 c.651C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067421 c.525G>C synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067427 c.519G>C synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067472 c.474C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067487 c.459G>A synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067490 c.456C>A synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067500 p.Lys149Arg missense_variant 0.31 para-aminosalicylic_acid
thyX 3067503 p.Ala148Ser missense_variant 0.29 para-aminosalicylic_acid
thyX 3067510 c.436C>T synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.31 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067676 c.270C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.36 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.49 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.5 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.51 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.53 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067784 c.162C>G synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.51 para-aminosalicylic_acid
thyX 3067835 c.111G>A synonymous_variant 0.56 para-aminosalicylic_acid
thyX 3067838 c.108C>G synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.55 para-aminosalicylic_acid
thyX 3067853 c.93C>T synonymous_variant 0.52 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.47 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.48 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.44 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.47 para-aminosalicylic_acid
thyX 3067935 p.Thr4Ile missense_variant 0.33 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073872 p.Ile200Met missense_variant 0.19 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073893 c.579C>T synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.23 para-aminosalicylic_acid
thyA 3073902 c.570C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073917 c.555C>A synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074045 c.427C>T synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.34 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.34 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074118 c.354G>A synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074147 p.Ile109Val missense_variant 0.31 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAA frameshift_variant&missense_variant 0.3 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074184 c.288A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074199 c.273G>A synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.28 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074235 c.237C>T synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074244 c.228A>T synonymous_variant 0.25 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087641 c.822T>C synonymous_variant 0.21 cycloserine
ald 3087647 c.828A>G synonymous_variant 0.21 cycloserine
ald 3087649 p.Gly277Asp missense_variant 0.21 cycloserine
ald 3087653 c.834A>G synonymous_variant 0.22 cycloserine
ald 3087656 c.837A>G synonymous_variant 0.21 cycloserine
ald 3087672 p.His285Asp missense_variant 0.21 cycloserine
ald 3087680 c.861G>C synonymous_variant 0.21 cycloserine
ald 3087685 p.Ala289Val missense_variant 0.21 cycloserine
ald 3087716 c.897G>C synonymous_variant 0.2 cycloserine
ald 3087737 c.918G>C synonymous_variant 0.26 cycloserine
ald 3087749 c.930C>G synonymous_variant 0.24 cycloserine
ald 3087750 p.Tyr311Val missense_variant 0.23 cycloserine
ald 3087761 c.942C>G synonymous_variant 0.23 cycloserine
ald 3087776 c.957G>C synonymous_variant 0.27 cycloserine
ald 3087787 p.Glu323Ala missense_variant 0.31 cycloserine
ald 3087791 c.972T>C synonymous_variant 0.31 cycloserine
ald 3087799 p.His327Arg missense_variant 0.32 cycloserine
ald 3087821 c.1002G>C synonymous_variant 0.3 cycloserine
ald 3087825 p.Asn336Asp missense_variant 0.29 cycloserine
ald 3087829 p.Pro337His missense_variant 0.28 cycloserine
ald 3087833 c.1014A>T synonymous_variant 0.26 cycloserine
ald 3087836 c.1017A>G synonymous_variant 0.26 cycloserine
ald 3087838 p.Ala340Gly missense_variant 0.26 cycloserine
ald 3087860 p.Glu347Asp missense_variant 0.25 cycloserine
ald 3087863 c.1044G>C synonymous_variant 0.23 cycloserine
ald 3087869 c.1050A>G synonymous_variant 0.21 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
Rv3236c 3613221 c.-105C>T upstream_gene_variant 1.0 pyrazinamide
lpqB 3623441 p.Ser490Asn missense_variant 0.19 bedaquiline
rifampicin
lpqB 3623444 c.1467T>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3623449 c.1462C>T synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3623456 c.1455T>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3623464 c.1447C>A synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3623468 c.1443T>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623471 c.1440C>T synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3623474 c.1437C>G synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3623484 p.Phe476Tyr missense_variant 0.3 bedaquiline
rifampicin
lpqB 3623489 c.1422C>G synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3623492 c.1419T>C synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3623512 p.Gly467Ser missense_variant 0.35 bedaquiline
rifampicin
lpqB 3623528 c.1383G>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623531 c.1380T>C synonymous_variant 0.36 bedaquiline
rifampicin
lpqB 3623555 c.1354_1356delGGGinsAC frameshift_variant&missense_variant 0.39 bedaquiline
rifampicin Uncertain significance
lpqB 3623561 c.1350T>C synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3623573 c.1338T>G synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3623576 c.1335T>C synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3623580 p.Asn444Thr missense_variant 0.3 bedaquiline
rifampicin
lpqB 3623587 p.Ala442Pro missense_variant 0.27 bedaquiline
rifampicin
lpqB 3623597 c.1314C>G synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3623601 p.Ser437Thr missense_variant 0.3 bedaquiline
rifampicin
lpqB 3623612 p.Thr433Val missense_variant 0.27 bedaquiline
rifampicin
lpqB 3623630 c.1281G>C synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3623648 c.1263A>G synonymous_variant 0.37 bedaquiline
rifampicin
lpqB 3623654 p.Asp419Glu missense_variant 0.36 bedaquiline
rifampicin
lpqB 3623660 c.1251A>T synonymous_variant 0.38 bedaquiline
rifampicin
lpqB 3623666 c.1245A>G synonymous_variant 0.37 bedaquiline
rifampicin
lpqB 3623676 p.Val412Asn missense_variant 0.29 bedaquiline
rifampicin
lpqB 3623682 p.Thr410Gly missense_variant 0.26 bedaquiline
rifampicin
lpqB 3623684 c.1227T>C synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3623699 c.1212C>G synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3623703 p.Ala403Val missense_variant 0.29 bedaquiline
rifampicin
lpqB 3623721 p.Ser397Thr missense_variant 0.24 bedaquiline
rifampicin
lpqB 3623990 c.921G>C synonymous_variant 0.26 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3623999 c.912C>G synonymous_variant 0.38 bedaquiline
rifampicin
lpqB 3624002 c.909G>C synonymous_variant 0.38 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624014 c.897T>C synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624026 p.Glu295Asp missense_variant 0.38 bedaquiline
rifampicin
lpqB 3624030 p.Ala294Arg missense_variant 0.39 bedaquiline
rifampicin
lpqB 3624032 c.879T>C synonymous_variant 0.39 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624037 c.874A>C synonymous_variant 0.42 bedaquiline
rifampicin
lpqB 3624041 p.Glu290Asp missense_variant 0.41 bedaquiline
rifampicin
lpqB 3624050 c.861C>G synonymous_variant 0.42 bedaquiline
rifampicin
lpqB 3624077 c.834G>C synonymous_variant 0.4 bedaquiline
rifampicin
lpqB 3624082 c.829A>C synonymous_variant 0.38 bedaquiline
rifampicin
lpqB 3624086 c.825C>T synonymous_variant 0.36 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624094 c.817A>C synonymous_variant 0.37 bedaquiline
rifampicin
lpqB 3624100 c.811T>C synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624101 c.810C>G synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624116 c.795A>G synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3624119 c.792C>G synonymous_variant 0.36 bedaquiline
rifampicin
lpqB 3624124 p.Leu263Val missense_variant 0.34 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624146 c.765C>G synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3624166 p.Met249Leu missense_variant 0.29 bedaquiline
rifampicin
lpqB 3624173 c.738A>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624179 c.732C>T synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624200 c.711A>G synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624204 p.Ser236Asn missense_variant 0.33 bedaquiline
rifampicin
lpqB 3624209 c.702A>T synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624224 c.687T>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624371 c.540T>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624389 c.522C>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624431 c.480C>T synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624464 c.447A>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624470 c.441T>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625087 c.1525_1527delGCCinsTG frameshift_variant&missense_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625093 p.Glu507Asp missense_variant 0.24 bedaquiline
rifampicin
lpqB 3625099 c.-189C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625117 c.-207T>G upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 0.28 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625138 c.-228C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625141 c.-231T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.33 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.26 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625189 c.-279A>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625195 c.-285A>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625206 p.Ser470Ala missense_variant 0.28 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625243 c.-333T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625255 c.-345T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3625301 p.Ala438Gly missense_variant 0.3 bedaquiline
rifampicin
mtrB 3625313 p.Arg434Lys missense_variant 0.2 bedaquiline
rifampicin
lpqB 3625315 c.-405G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625525 c.-615G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.24 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.25 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.25 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625648 c.-738T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.21 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.3 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>T synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625777 c.-867C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625797 p.Val273Met missense_variant 0.33 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625801 c.-891G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625843 c.-933C>G upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625849 c.-939T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626101 p.Gln171His missense_variant 0.18 bedaquiline
rifampicin
mtrB 3626110 c.504C>G synonymous_variant 0.22 bedaquiline
rifampicin
mtrB 3626124 p.Ala164Ser missense_variant 0.24 bedaquiline
rifampicin
mtrB 3626125 c.489C>G synonymous_variant 0.24 bedaquiline
rifampicin
mtrB 3626155 c.457_459delGCGinsTC frameshift_variant&missense_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626467 c.147G>A synonymous_variant 0.91 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3626704 c.-91C>T upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626765 c.585C>T synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.49 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627005 c.-392G>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3627125 c.-512C>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3627175 c.175C>T synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627181 c.-568T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627196 c.-583C>T upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3627209 c.-596G>A upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627263 c.-650C>T upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.35 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3627343 p.Thr3Ser missense_variant 0.28 bedaquiline
rifampicin
mtrA 3627602 c.-253C>T upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627845 c.-496C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
fbiB 3641864 c.330A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3641876 c.342C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiB 3641879 c.345G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3641880 p.Ser116Asp missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3641900 c.366G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3641906 c.372T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3641909 c.375T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3641914 p.Ala127Gly missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3641918 c.384T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3641924 c.390A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiB 3641927 c.393C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiB 3641928 c.394T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiB 3641938 p.Gly135Ala missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiB 3642560 c.1026T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642566 c.1032A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3642581 c.1047A>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiB 3642593 c.1059G>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiB 3642602 c.1068A>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiB 3642605 c.1071A>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiB 3642608 c.1074C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiB 3642609 c.1075_1076delAGinsTC synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiB 3642614 c.1080C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiB 3642620 c.1086T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiB 3642659 c.1125C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiB 3642668 c.1134A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiB 3642680 c.1146A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
alr 3841546 c.-126C>A upstream_gene_variant 1.0 cycloserine
alr 3841568 c.-148G>A upstream_gene_variant 1.0 cycloserine
rpoA 3877503 c.1005G>C synonymous_variant 0.23 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.24 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.23 rifampicin
rpoA 3877527 c.981C>G synonymous_variant 0.28 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.33 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.39 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.42 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.37 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.37 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.36 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.29 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.25 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.23 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.2 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.2 rifampicin
rpoA 3877899 p.Ser203Asn missense_variant 0.21 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.21 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.27 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.41 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.41 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.39 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.39 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>A synonymous_variant 0.39 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.37 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.34 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.35 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.34 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.34 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.35 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.33 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.32 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.26 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.22 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.21 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.32 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.35 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.38 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Ala missense_variant 0.38 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.39 rifampicin
rpoA 3878313 c.195G>T synonymous_variant 0.37 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.45 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.44 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.43 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.43 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.39 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.39 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.39 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.33 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.3 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.3 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.28 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.29 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.29 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.29 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.27 rifampicin
rpoA 3878713 c.-206G>C upstream_gene_variant 0.32 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.32 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.31 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.28 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.28 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.27 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.24 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.27 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.28 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.4 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.44 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.46 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.47 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.43 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.42 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.52 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.5 rifampicin Uncertain significance
rpoA 3878890 c.-383C>G upstream_gene_variant 0.53 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.55 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.56 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.57 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.49 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.47 rifampicin Uncertain significance
rpoA 3878953 c.-446C>T upstream_gene_variant 0.47 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.46 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.5 rifampicin
rpoA 3878986 c.-479G>C upstream_gene_variant 0.51 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.48 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.45 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.45 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.5 rifampicin
rpoA 3879033 c.-526C>T upstream_gene_variant 0.52 rifampicin
rpoA 3879034 c.-527G>A upstream_gene_variant 0.52 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.47 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.48 rifampicin
rpoA 3879085 c.-578C>T upstream_gene_variant 0.48 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.48 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.45 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.4 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.41 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.38 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.37 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.32 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.26 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.19 rifampicin
ddn 3986648 c.-196C>G upstream_gene_variant 0.2 delamanid
pretomanid
clpC1 4038255 p.Val817Lys missense_variant 0.31 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.23 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.23 pyrazinamide
clpC1 4038275 c.2430A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038308 c.2397G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.3 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.28 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.32 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.31 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.29 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.32 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.34 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.36 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.37 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038497 p.Ser736Gln missense_variant 0.36 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.43 pyrazinamide
clpC1 4038551 c.2154C>G synonymous_variant 0.46 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.38 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.33 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.36 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.39 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.36 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.34 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.43 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.35 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.42 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.4 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.52 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.51 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.46 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.45 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.41 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.53 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.61 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.65 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.65 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.39 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039328 c.1377A>C synonymous_variant 0.3 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.27 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.33 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>A synonymous_variant 0.33 pyrazinamide
clpC1 4039576 p.Ala377Pro missense_variant 0.33 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039583 c.1122C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.43 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039781 c.924G>T synonymous_variant 0.21 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039805 c.900C>A synonymous_variant 0.23 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.22 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.47 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.47 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.39 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.37 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.19 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.28 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.35 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040297 c.408G>A synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040318 c.387C>G synonymous_variant 0.34 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040345 c.360C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.24 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.31 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.32 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.34 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040414 c.291G>A synonymous_variant 0.22 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.21 pyrazinamide
clpC1 4040486 c.219G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040517 p.Val63Ala missense_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040567 c.138C>A synonymous_variant 0.16 pyrazinamide
panD 4044642 c.-361C>T upstream_gene_variant 0.21 pyrazinamide
panD 4044647 c.-366C>G upstream_gene_variant 0.22 pyrazinamide
panD 4044662 c.-381C>A upstream_gene_variant 0.22 pyrazinamide
panD 4044668 c.-387G>C upstream_gene_variant 0.21 pyrazinamide
panD 4044672 c.-392_-391delGCinsCA upstream_gene_variant 0.2 pyrazinamide
panD 4044674 c.-393C>G upstream_gene_variant 0.2 pyrazinamide
panD 4044677 c.-396T>C upstream_gene_variant 0.21 pyrazinamide
panD 4044682 c.-401C>A upstream_gene_variant 0.26 pyrazinamide
panD 4044688 c.-407T>C upstream_gene_variant 0.26 pyrazinamide
panD 4044692 c.-411G>C upstream_gene_variant 0.28 pyrazinamide
panD 4044700 c.-419C>A upstream_gene_variant 0.28 pyrazinamide
panD 4044704 c.-423G>C upstream_gene_variant 0.29 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.28 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.3 pyrazinamide
panD 4044728 c.-447C>T upstream_gene_variant 0.3 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.33 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.32 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.29 pyrazinamide
panD 4044781 c.-500C>T upstream_gene_variant 0.17 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.19 pyrazinamide
panD 4044819 c.-538C>A upstream_gene_variant 0.18 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.24 pyrazinamide
panD 4044959 c.-678C>G upstream_gene_variant 0.28 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.29 pyrazinamide
panD 4044983 c.-702G>C upstream_gene_variant 0.29 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.3 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.31 pyrazinamide
panD 4045004 c.-723C>T upstream_gene_variant 0.27 pyrazinamide
panD 4045009 c.-728G>A upstream_gene_variant 0.27 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.24 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.26 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.25 pyrazinamide
panD 4045034 c.-753A>G upstream_gene_variant 0.24 pyrazinamide
panD 4045052 c.-771G>C upstream_gene_variant 0.21 pyrazinamide
panD 4045063 c.-782T>C upstream_gene_variant 0.21 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.22 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.22 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.24 pyrazinamide
panD 4045088 c.-807T>C upstream_gene_variant 0.21 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138418 c.1338T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138424 c.1332T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138429 c.1327T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138436 c.1320C>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138442 c.1314C>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138451 c.1305T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138472 c.1284G>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138478 c.1278T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138481 c.1275G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138490 c.1266G>T synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138495 p.Gln421Glu missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138496 c.1260G>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138502 c.1254T>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138514 c.1242A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138517 p.Glu413Ala missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138523 c.1233C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138565 c.1191G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138622 c.1134C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138628 c.1128T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138685 c.1071C>A synonymous_variant 0.19 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin
isoniazid
glpK 4139132 c.624A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139135 c.619_621delGATinsAC frameshift_variant&synonymous_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139143 c.613T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139150 c.606G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139165 c.591A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139168 c.588T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139177 c.579T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139183 c.573T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139186 c.570G>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139195 c.561G>T synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139198 c.558C>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139228 c.528G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139231 c.525A>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139243 c.513A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139541 p.Ile72Thr missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139545 c.211T>C synonymous_variant 0.22 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139552 c.202_204delGCGinsTC frameshift_variant&missense_variant 0.25 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139561 c.195G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139588 c.168G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
embC 4240178 c.316T>C synonymous_variant 0.19 ethambutol
embC 4240183 c.321A>G synonymous_variant 0.21 ethambutol
embC 4240204 c.342T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4240216 c.354T>C synonymous_variant 0.26 ethambutol
embC 4240222 c.360G>T synonymous_variant 0.24 ethambutol
embC 4240229 c.367_369delCTGinsAC frameshift_variant&missense_variant 0.22 ethambutol
embC 4240232 p.Gln124Val missense_variant 0.23 ethambutol
embC 4240249 p.Asp129Glu missense_variant 0.24 ethambutol
embC 4240258 c.396T>G synonymous_variant 0.25 ethambutol
embC 4240270 c.408T>C synonymous_variant 0.19 ethambutol
embC 4240277 p.Leu139Val missense_variant 0.19 ethambutol
embC 4240282 c.420C>G synonymous_variant 0.2 ethambutol
embC 4240284 p.Thr141Ser missense_variant 0.2 ethambutol
embC 4240297 c.435T>C synonymous_variant 0.19 ethambutol
embC 4240313 p.Thr151Ala missense_variant 0.21 ethambutol
embC 4240318 c.456T>C synonymous_variant 0.19 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.28 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.4 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.4 ethambutol
embC 4240670 p.Thr270Leu missense_variant 0.49 ethambutol
embC 4240678 c.816T>G synonymous_variant 0.44 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.44 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.41 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.28 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.27 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.26 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.3 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.3 ethambutol
embC 4240831 c.969T>C synonymous_variant 0.33 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.32 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.31 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.3 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.28 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.28 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.28 ethambutol
embC 4240903 c.1041C>G synonymous_variant 0.28 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.26 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.26 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.25 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.27 ethambutol
embC 4240945 c.1083T>G synonymous_variant 0.28 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.2 ethambutol
embC 4241002 c.1140G>C synonymous_variant 0.2 ethambutol
embC 4241013 p.Met384Thr missense_variant 0.26 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.25 ethambutol
embC 4241023 c.1161T>C synonymous_variant 0.27 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.3 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.3 ethambutol
embC 4241042 p.Asn394Asp missense_variant 0.7 ethambutol Not assoc w R
embC 4241047 c.1185C>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4241048 c.1186_1188delCTTinsTG frameshift_variant&missense_variant 0.33 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.31 ethambutol
embC 4241081 c.1219C>T synonymous_variant 0.39 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.4 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.45 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.39 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.35 ethambutol
embC 4241158 c.1296T>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4241161 c.1299C>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.29 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.34 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embC 4241230 c.1368A>G synonymous_variant 0.25 ethambutol
embC 4241233 c.1371G>C synonymous_variant 0.22 ethambutol
embC 4241383 c.1521G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4241394 p.Lys511Ser missense_variant 0.22 ethambutol
embC 4241426 c.1564C>T synonymous_variant 0.27 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.37 ethambutol
embC 4241453 c.1591_1593delATCinsGG frameshift_variant&missense_variant 0.33 ethambutol
embC 4241476 c.1614G>C synonymous_variant 0.34 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.34 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.35 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.36 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.36 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.31 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.31 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.32 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.33 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embC 4241527 c.1665C>G synonymous_variant 0.33 ethambutol
embC 4241530 c.1668C>A synonymous_variant 0.33 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.31 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.25 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.25 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.24 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.27 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.27 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.29 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.31 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.31 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.29 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.29 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.35 ethambutol
embC 4241635 c.1773G>C synonymous_variant 0.34 ethambutol
embC 4241644 c.1782G>C synonymous_variant 0.37 ethambutol
embC 4241647 c.1785G>A synonymous_variant 0.37 ethambutol
embC 4241648 c.1786T>C synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embC 4241657 p.Ser599Pro missense_variant 0.4 ethambutol
embC 4241665 c.1803G>C synonymous_variant 0.48 ethambutol
embC 4241671 c.1809T>G synonymous_variant 0.52 ethambutol
embC 4241691 p.Gly610Ala missense_variant 0.56 ethambutol Uncertain significance
embC 4241694 p.Ala611Val missense_variant 0.57 ethambutol
embC 4241698 c.1836G>C synonymous_variant 0.57 ethambutol
embC 4241704 c.1842C>G synonymous_variant 0.59 ethambutol
embC 4241713 c.1851G>C synonymous_variant 0.57 ethambutol
embC 4241719 c.1857G>C synonymous_variant 0.55 ethambutol
embC 4241727 p.Phe622Tyr missense_variant 0.44 ethambutol
embC 4241731 c.1869C>G synonymous_variant 0.39 ethambutol
embC 4241741 c.1879_1881delGTCinsTG frameshift_variant&missense_variant 0.37 ethambutol
embC 4241747 p.Val629Leu missense_variant 0.31 ethambutol
embC 4241750 p.Leu630Val missense_variant 0.3 ethambutol
embC 4241755 c.1893C>G synonymous_variant 0.26 ethambutol
embC 4241761 c.1899G>C synonymous_variant 0.24 ethambutol
embC 4241770 c.1908T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4242820 c.-413G>C upstream_gene_variant 0.21 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.2 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.2 ethambutol
embC 4242841 c.2979C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embA 4242847 c.-386C>A upstream_gene_variant 0.19 ethambutol
embC 4242863 p.Tyr1001Asn missense_variant 0.18 ethambutol
embC 4242883 c.3021C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embA 4242886 c.-347G>A upstream_gene_variant 0.23 ethambutol
embA 4242892 c.-341G>C upstream_gene_variant 0.24 ethambutol
embA 4242901 c.-332G>C upstream_gene_variant 0.26 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.18 ethambutol
embA 4245077 c.1845G>C synonymous_variant 0.25 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.26 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.28 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.34 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.36 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.35 ethambutol
embA 4245167 c.1935G>A synonymous_variant 0.42 ethambutol
embA 4245173 c.1941G>C synonymous_variant 0.43 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.44 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.43 ethambutol
embA 4245206 c.1974A>G synonymous_variant 0.37 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.36 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.38 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.35 ethambutol Uncertain significance
embA 4245257 c.2025A>G synonymous_variant 0.37 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embA 4245282 p.Ile684Val missense_variant 0.33 ethambutol
embA 4245285 c.2053T>C synonymous_variant 0.31 ethambutol
embA 4245290 c.2058C>G synonymous_variant 0.31 ethambutol
embA 4245293 c.2061T>G synonymous_variant 0.31 ethambutol
embA 4245296 c.2064G>C synonymous_variant 0.3 ethambutol
embA 4245299 c.2067A>G synonymous_variant 0.31 ethambutol
embA 4245315 p.Val695Thr missense_variant 0.25 ethambutol
embA 4245328 p.Ala699Val missense_variant 0.27 ethambutol
embA 4245335 c.2103A>G synonymous_variant 0.27 ethambutol
embA 4245340 p.Gly703Ala missense_variant 0.29 ethambutol
embA 4245345 p.Met705Leu missense_variant 0.3 ethambutol
embA 4245348 p.Ala706Thr missense_variant 0.28 ethambutol
embA 4245355 p.Ala708Gly missense_variant 0.29 ethambutol
embA 4245368 c.2136T>C synonymous_variant 0.29 ethambutol
embA 4245377 c.2145T>C synonymous_variant 0.33 ethambutol
embA 4245388 p.Ala719Gly missense_variant 0.26 ethambutol
embA 4245401 c.2169G>C synonymous_variant 0.22 ethambutol
embA 4245402 p.Thr724Ala missense_variant 0.22 ethambutol
embA 4245408 p.Leu726Ile missense_variant 0.21 ethambutol
embA 4245414 c.2182_2184delACCinsTG frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
embA 4245424 c.2193_2194insCCCAGC conservative_inframe_insertion 0.22 ethambutol
embA 4245431 c.2199T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embA 4245458 c.2226G>A synonymous_variant 0.24 ethambutol
embA 4245470 c.2238T>C synonymous_variant 0.21 ethambutol
embA 4245480 c.2248C>T synonymous_variant 0.23 ethambutol
embA 4245484 p.Gln751Pro missense_variant 0.21 ethambutol Uncertain significance
embA 4245490 p.Val753Ala missense_variant 0.21 ethambutol
embA 4245501 c.2269_2271delGCGinsAC frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
embA 4245509 c.2277A>C synonymous_variant 0.18 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.21 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.2 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.23 ethambutol
embB 4245767 c.-747G>A upstream_gene_variant 0.22 ethambutol
embA 4245771 p.Asn847Ser missense_variant 0.22 ethambutol Uncertain significance
embA 4245811 p.Pro860Leu missense_variant 0.19 ethambutol Uncertain significance
embB 4245851 c.-663G>C upstream_gene_variant 0.21 ethambutol
embB 4245860 c.-654C>G upstream_gene_variant 0.19 ethambutol
embA 4245969 p.Pro913Ser missense_variant 0.95 ethambutol Not assoc w R
embB 4247386 c.873T>C synonymous_variant 0.2 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.21 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.23 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.25 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.26 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.28 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.36 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.38 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.39 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.48 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.52 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.52 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.48 ethambutol
embB 4247521 c.1008G>C synonymous_variant 0.43 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.31 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.26 ethambutol
embB 4247566 c.1053C>G synonymous_variant 0.22 ethambutol
embB 4247567 c.1054C>T synonymous_variant 0.22 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.22 ethambutol
embB 4247611 c.1098G>C synonymous_variant 0.19 ethambutol
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247683 c.1170C>G synonymous_variant 0.23 ethambutol
embB 4247692 c.1179C>G synonymous_variant 0.25 ethambutol
embB 4247722 c.1209G>T synonymous_variant 0.2 ethambutol
embB 4247725 c.1212G>C synonymous_variant 0.21 ethambutol
embB 4247728 c.1215G>A synonymous_variant 0.21 ethambutol
embB 4247729 p.Gly406Pro missense_variant 0.21 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.21 ethambutol
embB 4247776 c.1263G>C synonymous_variant 0.24 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.25 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.25 ethambutol
embB 4247809 c.1296G>A synonymous_variant 0.27 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.21 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.21 ethambutol
embB 4247830 c.1317A>C synonymous_variant 0.26 ethambutol
embB 4247836 c.1323A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4247876 c.1363C>T synonymous_variant 0.39 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.38 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.36 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.34 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embB 4247914 c.1401G>C synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.19 ethambutol
embB 4247944 c.1431G>T synonymous_variant 0.17 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.17 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.23 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.21 ethambutol
embB 4248073 c.1560C>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4248085 c.1572T>C synonymous_variant 0.3 ethambutol
embB 4248094 c.1581C>T synonymous_variant 0.31 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.32 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.37 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.4 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.4 ethambutol
embB 4248145 p.Leu544Phe missense_variant 0.38 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embB 4248169 c.1656C>G synonymous_variant 0.35 ethambutol
embB 4248172 c.1659G>C synonymous_variant 0.34 ethambutol
embB 4248199 c.1686A>T synonymous_variant 0.39 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.38 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.39 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.39 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.26 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.24 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.23 ethambutol
embB 4248325 c.1812G>C synonymous_variant 0.23 ethambutol
embB 4249375 c.2862G>C synonymous_variant 0.25 ethambutol
embB 4249381 c.2868A>G synonymous_variant 0.25 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.29 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.33 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.33 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.31 ethambutol
embB 4249441 c.2928A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.31 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.31 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.31 ethambutol
embB 4249486 c.2973T>A synonymous_variant 0.35 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.36 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.31 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.29 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.29 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.3 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.27 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.27 ethambutol
embB 4249558 c.3045A>G synonymous_variant 0.29 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.28 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.27 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.28 ethambutol
embB 4249594 c.3081G>C synonymous_variant 0.26 ethambutol
embB 4249609 c.3096T>C synonymous_variant 0.25 ethambutol
aftB 4268099 c.738G>C synonymous_variant 0.32 ethambutol
aftB 4268102 c.735C>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
aftB 4268105 c.732T>C synonymous_variant 0.32 ethambutol
aftB 4268117 c.720G>C synonymous_variant 0.36 ethambutol
aftB 4268123 c.712_714delAGTinsGG frameshift_variant&missense_variant 0.34 ethambutol Uncertain significance
aftB 4268129 c.708T>G synonymous_variant 0.36 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
aftB 4268164 p.Gln225Glu missense_variant 0.33 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.31 ethambutol
aftB 4268179 c.658T>C synonymous_variant 0.34 ethambutol Not assoc w R - Interim
aftB 4268183 c.654A>T synonymous_variant 0.35 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 0.35 ethambutol
aftB 4268203 c.634C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
aftB 4268205 p.Val211Ala missense_variant 0.29 ethambutol
aftB 4268213 c.624T>G synonymous_variant 0.27 ethambutol
aftB 4268225 c.612G>C synonymous_variant 0.28 ethambutol
aftB 4268228 c.609C>G synonymous_variant 0.26 ethambutol
aftB 4268236 c.601T>C synonymous_variant 0.25 ethambutol
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326439 p.Asn345Lys missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338635 c.-114A>C upstream_gene_variant 1.0 capreomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 1.0 streptomycin Not assoc w R