TB-Profiler result

Run: SRR1791747
Summary

Run ID: SRR1791747

Sample name:

Date: 2024-04-15T15:00:45.133762

Number of reads: 730409

Percentage reads mapped: 53.23

Median coverage: 27.0

Strain: La1.8.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.8 M.bovis None 1.0
La1.8.1 M.bovis None 1.0
La1 M.bovis None 0.93
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6406 c.1167C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7397 c.96G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7412 c.111C>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7433 c.132G>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7451 c.150C>T synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7454 c.153G>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.56 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.56 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.59 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.62 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.6 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.59 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7613 c.312G>A synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7637 c.336C>A synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7667 c.366C>T synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCT frameshift_variant&missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7706 c.405C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7709 c.408G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.41 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7769 c.468C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7775 c.474C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7784 c.483A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7790 c.489G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7796 c.495G>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7808 c.507G>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8126 c.825G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8129 c.828T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8191 p.Ala297Gly missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8198 c.897T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8222 c.921C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8225 c.924T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8240 c.939C>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8315 c.1014G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364Leu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8408 c.1107A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8414 c.1113C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8433 p.Thr378Arg missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8456 c.1155C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8477 c.1176C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8513 c.1212C>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8520 c.1219C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8535 p.Glu412Gln missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8549 c.1248C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9217 p.Asp639Ala missense_variant 0.9 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575725 c.378C>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.33 ethionamide
isoniazid
mshA 575744 p.Ala133Thr missense_variant 0.33 ethionamide
isoniazid Uncertain significance
mshA 575749 c.402C>A synonymous_variant 0.33 ethionamide
isoniazid
mshA 575764 c.417C>G synonymous_variant 0.37 ethionamide
isoniazid
mshA 575771 p.Val142Thr missense_variant 0.35 ethionamide
isoniazid
mshA 575776 c.429C>T synonymous_variant 0.35 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.32 ethionamide
isoniazid
mshA 575800 c.453G>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.31 ethionamide
isoniazid Not assoc w R - Interim
mshA 575821 c.474G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.27 ethionamide
isoniazid
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
rpoB 760181 c.375T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.41 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.44 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.43 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.43 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.41 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.42 rifampicin Uncertain significance
rpoB 760406 c.600G>T synonymous_variant 0.39 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.39 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.41 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.41 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.36 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.36 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.36 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.28 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.27 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.27 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.29 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.31 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.31 rifampicin
rpoB 760784 c.978G>T synonymous_variant 0.3 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.31 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.34 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.31 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.31 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.25 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 0.24 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.24 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.23 rifampicin
rpoB 760887 p.Thr361Val missense_variant 0.23 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.23 rifampicin
rpoB 761111 c.1305C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761213 c.1407G>C synonymous_variant 0.3 rifampicin
rpoB 761217 p.Pro471Ser missense_variant 0.29 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761408 c.1602G>C synonymous_variant 0.24 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761516 c.1710G>C synonymous_variant 0.17 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761552 c.1746G>C synonymous_variant 0.24 rifampicin
rpoB 761555 c.1749G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.24 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.26 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.22 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.26 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.26 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.26 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.36 rifampicin
rpoB 761708 c.1902C>T synonymous_variant 0.42 rifampicin
rpoB 761712 p.Val636Ile missense_variant 0.42 rifampicin
rpoB 761718 c.1912_1913delGCinsT frameshift_variant&missense_variant 0.4 rifampicin
rpoB 761722 p.Glu639Gly missense_variant 0.4 rifampicin Uncertain significance
rpoB 761727 p.Ser641Gly missense_variant 0.4 rifampicin
rpoB 761732 c.1926_1927delCGinsGCA frameshift_variant&missense_variant 0.42 rifampicin
rpoB 761736 p.Ile644Val missense_variant 0.4 rifampicin Uncertain significance
rpoB 761747 c.1941G>C synonymous_variant 0.4 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.32 rifampicin
rpoB 761828 c.2022C>T synonymous_variant 0.35 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.36 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.36 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.53 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>A synonymous_variant 0.68 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.71 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.63 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.61 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.59 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 762374 c.-996G>C upstream_gene_variant 0.29 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.35 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.35 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.32 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.39 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.39 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.33 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.3 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.3 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762533 c.-837T>C upstream_gene_variant 0.27 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.23 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.23 rifampicin
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.24 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.53 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.46 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.36 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.36 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.31 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.28 rifampicin
rpoC 763190 c.-180C>T upstream_gene_variant 0.24 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>T synonymous_variant 0.37 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.45 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.5 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.53 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.54 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.54 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.52 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.52 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763792 p.Glu141Asp missense_variant 0.7 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.69 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.7 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.68 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.66 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.62 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.58 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.59 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.59 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.57 rifampicin
rpoC 763882 c.513G>A synonymous_variant 0.55 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.61 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.61 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.55 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.55 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.55 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.57 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.57 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.57 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.58 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.58 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.54 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.5 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.43 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.43 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.41 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.43 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.41 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.37 rifampicin
rpoC 764071 c.702G>C synonymous_variant 0.28 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.22 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.21 rifampicin
rpoC 764089 c.720C>G synonymous_variant 0.22 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Gln missense_variant 0.19 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.39 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.39 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.41 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764195 c.826_828delTCGinsAGC synonymous_variant 0.37 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.41 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.41 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.41 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.39 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.39 rifampicin
rpoC 764227 c.858G>T synonymous_variant 0.39 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>A synonymous_variant 0.4 rifampicin
rpoC 764254 c.885G>C synonymous_variant 0.41 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.39 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.37 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.37 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.43 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.47 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.48 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.33 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.3 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.28 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.28 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.25 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.29 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.25 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.53 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.45 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.41 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.43 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.41 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.4 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.32 rifampicin Uncertain significance
rpoC 765400 c.2031G>C synonymous_variant 0.33 rifampicin
rpoC 765403 c.2034G>C synonymous_variant 0.33 rifampicin
rpoC 765404 p.Leu679Lys missense_variant 0.33 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.33 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.33 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 0.39 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 0.42 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.42 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.36 rifampicin Uncertain significance
rpoC 765496 c.2127C>G synonymous_variant 0.39 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.28 rifampicin
rpoC 765533 p.Tyr722His missense_variant 0.27 rifampicin Uncertain significance
rpoC 765700 c.2331T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765704 p.Lys779Gln missense_variant 0.29 rifampicin
rpoC 765709 p.Glu780Asp missense_variant 0.31 rifampicin
rpoC 765718 p.Asp783Glu missense_variant 0.32 rifampicin Uncertain significance
rpoC 765724 c.2355C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765728 p.Gln787Lys missense_variant 0.3 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765737 p.Arg790Glu missense_variant 0.32 rifampicin
rpoC 765743 p.His792Tyr missense_variant 0.37 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.37 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.37 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.33 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.32 rifampicin
rpoC 765779 c.2410_2412delGACinsAG frameshift_variant&missense_variant 0.32 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.35 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.35 rifampicin
rpoC 765800 p.Phe811Leu missense_variant 0.33 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.33 rifampicin
rpoC 765814 c.2445A>C synonymous_variant 0.33 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.33 rifampicin
rpoC 765823 c.2454C>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.44 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.44 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.48 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.42 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.33 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.38 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.38 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.37 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.37 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.35 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775720 p.Val921Ile missense_variant 0.3 clofazimine
bedaquiline
mmpL5 775723 p.Ile920Val missense_variant 0.27 clofazimine
bedaquiline
mmpL5 775736 c.2745C>G synonymous_variant 0.33 clofazimine
bedaquiline
mmpL5 775747 p.Met912Leu missense_variant 0.43 clofazimine
bedaquiline
mmpL5 775748 c.2733T>C synonymous_variant 0.4 clofazimine
bedaquiline
mmpL5 775763 c.2718T>G synonymous_variant 0.47 clofazimine
bedaquiline
mmpL5 775769 p.Ala904Gly missense_variant 0.42 clofazimine
bedaquiline
mmpL5 775772 p.Met903Ile missense_variant 0.4 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775780 p.Thr901Ala missense_variant 0.45 clofazimine
bedaquiline
mmpL5 775793 c.2688C>G synonymous_variant 0.52 clofazimine
bedaquiline
mmpL5 775796 c.2683_2685delTTTinsAG frameshift_variant&stop_gained 0.52 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775814 c.2667C>G synonymous_variant 0.57 clofazimine
bedaquiline
mmpL5 775817 c.2664T>C synonymous_variant 0.57 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775826 c.2655G>C synonymous_variant 0.54 clofazimine
bedaquiline
mmpL5 775829 c.2652C>G synonymous_variant 0.6 clofazimine
bedaquiline
mmpL5 775834 p.Ala883Ser missense_variant 0.58 clofazimine
bedaquiline
mmpL5 775838 c.2643G>C synonymous_variant 0.58 clofazimine
bedaquiline
mmpL5 775847 c.2634G>T synonymous_variant 0.6 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775851 p.Ser877Thr missense_variant 0.62 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.62 clofazimine
bedaquiline
mmpL5 775865 c.2616T>C synonymous_variant 0.57 clofazimine
bedaquiline
mmpL5 775877 c.2604C>G synonymous_variant 0.53 clofazimine
bedaquiline
mmpL5 775883 c.2596_2598delATCinsTG frameshift_variant&missense_variant 0.54 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775886 c.2595A>T synonymous_variant 0.57 clofazimine
bedaquiline
mmpL5 775892 c.2589C>T synonymous_variant 0.56 clofazimine
bedaquiline
mmpL5 775904 c.2577G>A synonymous_variant 0.64 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.56 clofazimine
bedaquiline
mmpL5 775915 p.Ala856Ser missense_variant 0.56 clofazimine
bedaquiline
mmpL5 775916 c.2565T>C synonymous_variant 0.61 clofazimine
bedaquiline
mmpL5 775921 c.2560C>T synonymous_variant 0.56 clofazimine
bedaquiline
mmpL5 775924 c.2557C>T synonymous_variant 0.56 clofazimine Not assoc w R - Interim
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.65 clofazimine
bedaquiline
mmpL5 775955 c.2524_2526delATCinsGG frameshift_variant&missense_variant 0.33 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775964 c.2515_2517delGCGinsTC frameshift_variant&missense_variant 0.34 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775970 c.2511G>A synonymous_variant 0.4 clofazimine
bedaquiline
mmpL5 775973 c.2506_2508delTTGinsAC frameshift_variant&missense_variant 0.3 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775981 p.Leu834Met missense_variant 0.51 clofazimine
bedaquiline
mmpL5 775994 c.2485_2487delATCinsCG frameshift_variant&missense_variant 0.48 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775997 c.2484T>G synonymous_variant 0.48 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 0.52 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776005 p.Ile826Leu missense_variant 0.52 clofazimine
bedaquiline
mmpL5 776009 c.2472A>G synonymous_variant 0.53 clofazimine
bedaquiline
mmpL5 776030 c.2451G>C synonymous_variant 0.45 clofazimine
bedaquiline
mmpL5 776053 c.2428T>C synonymous_variant 0.37 clofazimine
bedaquiline
mmpL5 776081 c.2400G>C synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 776084 c.2397C>G synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 776087 c.2394C>G synonymous_variant 0.29 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Leu missense_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.32 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.33 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.33 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.35 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.35 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.35 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.34 streptomycin
rpsL 781732 c.174_177delGAGT frameshift_variant 0.34 streptomycin Uncertain significance
rpsL 781739 c.180_181insCGGC frameshift_variant 0.31 streptomycin Uncertain significance
rpsL 781742 c.183C>T synonymous_variant 0.31 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.33 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.33 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.39 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.39 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.39 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.39 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.37 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.38 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.4 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.4 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.39 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.34 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.34 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.34 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.41 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.44 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.45 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.44 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.42 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.46 streptomycin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1304515 p.Ala529Thr missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304533 c.1603T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304541 c.1611C>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304546 p.Val539Ala missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304562 c.1632G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304567 p.Phe546Tyr missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.32 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
sigE 1364751 c.339C>G synonymous_variant 0.17 pyrazinamide
sigE 1364778 c.366G>C synonymous_variant 0.2 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.22 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.29 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.31 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.3 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.3 pyrazinamide
sigE 1364871 c.459C>T synonymous_variant 0.3 pyrazinamide
sigE 1364883 c.471G>A synonymous_variant 0.32 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.34 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.33 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.29 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.29 pyrazinamide
sigE 1364925 c.513C>G synonymous_variant 0.29 pyrazinamide
sigE 1364931 c.519C>T synonymous_variant 0.3 pyrazinamide
sigE 1364950 c.538_540delGCAinsTG frameshift_variant&stop_gained 0.22 pyrazinamide Uncertain significance
sigE 1364962 c.550_552delCCTinsGC frameshift_variant&missense_variant 0.22 pyrazinamide Uncertain significance
sigE 1364976 c.564T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.2 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.21 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.21 pyrazinamide
sigE 1364992 p.Pro194Ala missense_variant 0.21 pyrazinamide
sigE 1365000 c.588G>A synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
sigE 1365006 c.594T>C synonymous_variant 0.22 pyrazinamide
sigE 1365018 c.606G>C synonymous_variant 0.22 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.16 pyrazinamide
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>A non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473811 n.154_155insT non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473814 n.158delT non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473829 n.172G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230delTinsAA non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474288 n.631_632delCCinsTCGACT non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474292 n.635T>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474294 n.638_649delCTCTCCGGAGGA non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756_757delACinsTAT non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053T>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474711 n.1054G>C non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474716 n.1059_1063delAAAGCinsCCAAGAGT non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475353 n.1696A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475354 n.1697A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475379 n.1722G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475381 n.1724G>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475382 n.1725A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475395 n.1738T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid Uncertain significance
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475398 n.1741C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475604 n.1947A>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475618 n.1961C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475626 n.1969delTinsCC non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475643 n.1986C>G non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.6 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.52 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.47 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476746 n.3089T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476747 n.3090C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
inhA 1673886 c.-316C>T upstream_gene_variant 0.25 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.28 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 0.27 ethionamide
isoniazid
inhA 1673916 c.-286A>C upstream_gene_variant 0.25 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.25 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.27 ethionamide
isoniazid
inhA 1673931 c.-271C>G upstream_gene_variant 0.32 ethionamide
isoniazid
fabG1 1673941 c.502_504delGCCinsTG frameshift_variant&missense_variant 0.36 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.33 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.31 ethionamide
isoniazid
fabG1 1673962 p.Asn175Gly missense_variant 0.31 ethionamide
isoniazid
inhA 1673967 c.-235G>C upstream_gene_variant 0.31 ethionamide
isoniazid
inhA 1673973 c.-229G>C upstream_gene_variant 0.29 ethionamide
isoniazid Uncertain significance
inhA 1673976 c.-226T>C upstream_gene_variant 0.33 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.34 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.33 ethionamide
isoniazid
fabG1 1674037 p.Gln200Ala missense_variant 0.32 ethionamide
isoniazid
rpsA 1833628 c.87G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.28 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.29 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.38 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.38 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.38 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.41 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1833709 c.168C>T synonymous_variant 0.5 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.49 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 0.48 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.48 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.48 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.51 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.51 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.51 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.48 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.46 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.46 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.49 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.5 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.49 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.49 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.54 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.56 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.52 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.55 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.51 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.43 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.38 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.38 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.33 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.29 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.42 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.34 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834168 c.627C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834169 p.Thr210Ala missense_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.48 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>A synonymous_variant 0.49 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.51 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.5 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.58 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.64 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.7 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.64 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.59 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.51 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.47 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.38 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.35 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.35 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.35 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.22 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.23 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.23 pyrazinamide
rpsA 1834774 c.1233C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.24 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 1.0 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
ndh 2102193 p.Arg284Trp missense_variant 0.96 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2103173 c.-132delG upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
ndh 2103287 c.-245A>G upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168319 p.Thr765Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170048 p.Leu189Val missense_variant 0.63 pyrazinamide
PPE35 2170053 p.Thr187Ser missense_variant 0.65 pyrazinamide
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
eis 2715125 p.Thr70Ala missense_variant 1.0 amikacin Uncertain significance
kanamycin Uncertain significance
ahpC 2726144 c.-49T>C upstream_gene_variant 1.0 isoniazid
ahpC 2726441 c.249G>A synonymous_variant 1.0 isoniazid
Rv2477c 2782927 c.1116A>G synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2681 2997325 p.Ala196Val missense_variant 1.0 capreomycin Uncertain significance
Rv2752c 3065058 c.1134C>G synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065061 c.1131C>T synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065064 c.1128G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065070 c.1122C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065079 c.1113T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065082 c.1110G>T synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065085 c.1105_1107delAGGinsCC frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065088 c.1104A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065109 c.1081_1083delAGAinsCC frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065126 p.Ser356Ala missense_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065130 c.1062A>G synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065133 c.1059T>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623372 c.1539G>C synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3623730 p.Ser394Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624350 c.561G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624593 c.318G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624710 c.201G>A synonymous_variant 0.93 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625663 c.-753G>A upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3625711 c.903C>T synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626780 c.-167T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626786 c.-173A>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626792 c.-179G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626795 c.-182C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626798 c.-185T>A upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626843 c.-230G>T upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626864 c.484_486delTTGinsCC frameshift_variant&missense_variant 0.23 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626894 c.-281C>T upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3626906 c.442_444delAACinsCG frameshift_variant&missense_variant 0.26 bedaquiline
rifampicin
mtrA 3626909 c.441C>T synonymous_variant 0.28 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3626912 c.438T>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>G upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3626949 p.Ala134Asn missense_variant 0.38 bedaquiline
rifampicin
mtrB 3626954 c.-341C>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrA 3626962 p.Met130Leu missense_variant 0.43 bedaquiline
rifampicin
mtrA 3626969 c.381C>T synonymous_variant 0.41 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626972 c.-359A>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3626978 p.Asp124Glu missense_variant 0.52 bedaquiline
rifampicin Uncertain significance
mtrB 3626999 c.-386G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627002 c.-389G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627005 c.-392G>A upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627032 c.-419G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3627041 c.307_309delATCinsGG frameshift_variant&missense_variant 0.27 bedaquiline
rifampicin
mtrB 3627044 c.-431C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
rpoA 3877695 c.813C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.32 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.35 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.39 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.44 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.33 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.32 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.37 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.42 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>C synonymous_variant 0.45 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.46 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.49 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.51 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.53 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.51 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.51 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>G synonymous_variant 0.51 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.51 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.55 rifampicin
rpoA 3878061 c.447G>A synonymous_variant 0.57 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.55 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.58 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.51 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.48 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.48 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.45 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.4 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>A synonymous_variant 0.31 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878238 c.270C>T synonymous_variant 0.32 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.32 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.32 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.31 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.31 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878376 c.132G>A synonymous_variant 0.26 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.26 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878400 c.108T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878403 c.105C>T synonymous_variant 0.28 rifampicin
rpoA 3878409 c.99C>G synonymous_variant 0.26 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.26 rifampicin
rpoA 3878421 c.87A>T synonymous_variant 0.35 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.38 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.38 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.38 rifampicin
ddn 3986615 c.-229C>A upstream_gene_variant 0.3 delamanid
pretomanid
ddn 3986616 c.-228_-227delAGinsGC upstream_gene_variant 0.3 delamanid
pretomanid
ddn 3986622 c.-222C>T upstream_gene_variant 0.3 delamanid
pretomanid
ddn 3986633 c.-211C>T upstream_gene_variant 0.27 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.26 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.27 delamanid
pretomanid
ddn 3986651 c.-193G>A upstream_gene_variant 0.27 delamanid
pretomanid
ddn 3986661 c.-183C>A upstream_gene_variant 0.27 delamanid
pretomanid
ddn 3986667 c.-177_-175delCTCinsACG upstream_gene_variant 0.29 delamanid
pretomanid
ddn 3986696 c.-148G>C upstream_gene_variant 0.3 delamanid
pretomanid
ddn 3986699 c.-145C>A upstream_gene_variant 0.3 delamanid
pretomanid
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038563 c.2142C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038584 c.2121G>A synonymous_variant 0.32 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.33 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.32 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.29 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038665 c.2040C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038668 c.2037G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038677 c.2026_2028delCCGinsGT frameshift_variant&missense_variant 0.31 pyrazinamide
clpC1 4038683 c.2020_2022delTCTinsAGC synonymous_variant 0.3 pyrazinamide
clpC1 4038695 c.2010C>T synonymous_variant 0.32 pyrazinamide
clpC1 4038698 c.2007C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.34 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038721 c.1984C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 0.42 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.47 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.46 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.47 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.52 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.51 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.46 pyrazinamide
clpC1 4038830 c.1875C>T synonymous_variant 0.54 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.42 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.4 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.4 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.41 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.4 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.4 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.41 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.42 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.5 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4039082 c.1623C>T synonymous_variant 0.5 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.48 pyrazinamide
clpC1 4039100 c.1605C>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.49 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.52 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.49 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039199 c.1506C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039280 c.1425G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039319 c.1384_1386delGCTinsTC frameshift_variant&missense_variant 0.42 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.41 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.47 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039361 c.1344C>A synonymous_variant 0.52 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.52 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.53 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.5 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.5 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.58 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.43 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.42 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039598 c.1107C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.45 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.39 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.37 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.38 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.38 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.42 pyrazinamide
clpC1 4039913 c.792C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039943 c.762G>T synonymous_variant 0.46 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.46 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.4 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.42 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>T synonymous_variant 0.43 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.42 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>T synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4040141 c.564C>T synonymous_variant 0.32 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.34 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.36 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.39 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040177 c.528C>G synonymous_variant 0.4 pyrazinamide
clpC1 4040192 c.513C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040195 c.510G>C synonymous_variant 0.37 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.37 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.37 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.39 pyrazinamide
clpC1 4040213 p.Ser164Asn missense_variant 0.41 pyrazinamide
clpC1 4040219 c.486C>G synonymous_variant 0.41 pyrazinamide
clpC1 4040225 c.480A>T synonymous_variant 0.39 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.38 pyrazinamide
clpC1 4040237 c.468C>G synonymous_variant 0.44 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.5 pyrazinamide
clpC1 4040258 c.447G>A synonymous_variant 0.45 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.49 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040306 c.399G>C synonymous_variant 0.53 pyrazinamide
clpC1 4040309 c.396C>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4040324 c.381G>C synonymous_variant 0.55 pyrazinamide
clpC1 4040335 c.370C>T synonymous_variant 0.45 pyrazinamide
clpC1 4040336 c.369G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040345 c.360C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.42 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.41 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.41 pyrazinamide
clpC1 4040366 c.339C>T synonymous_variant 0.39 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.41 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.39 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.42 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.42 pyrazinamide
clpC1 4040433 c.271_272delAGinsTC synonymous_variant 0.42 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.41 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040462 c.243C>T synonymous_variant 0.42 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.42 pyrazinamide
clpC1 4040468 c.237G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040495 c.210C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.43 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.39 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.35 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.34 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.33 pyrazinamide
clpC1 4040591 c.114C>T synonymous_variant 0.32 pyrazinamide
clpC1 4040594 c.111G>T synonymous_variant 0.32 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.3 pyrazinamide
clpC1 4040600 c.105A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.31 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.33 pyrazinamide
clpC1 4040618 c.87C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.27 pyrazinamide
clpC1 4040648 c.57G>A synonymous_variant 0.24 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.22 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138535 c.1221T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138565 c.1191G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138583 c.1173G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138586 c.1170C>T synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138592 c.1164C>T synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138598 c.1158G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138616 p.Ala380Val missense_variant 0.33 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138622 c.1134C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138628 c.1128T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138646 c.1110G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138661 c.1095T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138676 c.1080T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4246434 p.Gln1068Glu missense_variant 1.0 ethambutol
embB 4246551 p.Asn13Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247455 c.942C>T synonymous_variant 0.2 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.2 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.19 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.19 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.19 ethambutol
embB 4247511 p.Tyr333Phe missense_variant 0.19 ethambutol
embB 4247527 c.1014G>C synonymous_variant 0.21 ethambutol
embB 4247536 c.1023C>G synonymous_variant 0.21 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.23 ethambutol
embB 4247555 c.1042_1044delCTGinsAC frameshift_variant&missense_variant 0.24 ethambutol
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248085 c.1572T>C synonymous_variant 0.18 ethambutol
embB 4248088 c.1575C>T synonymous_variant 0.18 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.2 ethambutol
embB 4248112 c.1599C>G synonymous_variant 0.19 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.18 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.18 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.18 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.18 ethambutol
embB 4248143 c.1630_1632delTTGinsAC frameshift_variant&missense_variant 0.18 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248158 p.Cys549Ser missense_variant 0.19 ethambutol
embB 4248167 p.Thr552Ala missense_variant 0.19 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.2 ethambutol
embB 4248173 p.Val554Leu missense_variant 0.2 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.2 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.2 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.21 ethambutol Uncertain significance
embB 4248214 c.1701C>T synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248220 c.1707A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248223 c.1710G>C synonymous_variant 0.21 ethambutol
embB 4248225 p.Ala571Val missense_variant 0.22 ethambutol Uncertain significance
embB 4248242 p.Val577Ile missense_variant 0.23 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.2 ethambutol
embB 4248256 c.1743C>G synonymous_variant 0.19 ethambutol
embB 4248264 p.Phe584Cys missense_variant 0.21 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.17 ethambutol
aftB 4267858 p.Ile327Val missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R