TB-Profiler result

Run: SRR1183049
Summary

Run ID: SRR1183049

Sample name:

Date: 2024-04-15T07:42:49.139130

Number of reads: 1462447

Percentage reads mapped: 58.39

Median coverage: 32.0

Strain: lineage2.2

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 0.95
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin tlyA c.-2_1delGCGinsCGGA Assoc w R
c.4_6delGCAinsTT Assoc w R
c.31_33delCTAinsTG Assoc w R
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.796_798delATCinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.916_918delTTCinsGA Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491578 c.796_798delATCinsCG frameshift_variant&missense_variant 0.33 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.65 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1303846 c.916_918delTTCinsGA frameshift_variant&missense_variant 0.59 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance Mutation from literature
tlyA 1917938 c.-2_1delGCGinsCGGA frameshift_variant&synonymous_variant 0.21 capreomycin Assoc w R
tlyA 1917943 c.4_6delGCAinsTT frameshift_variant&missense_variant 0.19 capreomycin Assoc w R
tlyA 1917970 c.31_33delCTAinsTG frameshift_variant&stop_gained 0.33 capreomycin Assoc w R
embB 4247448 p.His312Arg missense_variant 0.35 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 558 c.558G>C synonymous_variant 0.34 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.41 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 585 c.585A>G synonymous_variant 0.46 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.48 isoniazid
dnaA 597 c.597C>G synonymous_variant 0.46 isoniazid Not assoc w R - Interim
dnaA 600 c.600T>C synonymous_variant 0.44 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.36 isoniazid
dnaA 610 c.610C>T synonymous_variant 0.33 isoniazid
dnaA 705 c.705A>G synonymous_variant 0.35 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.33 isoniazid
dnaA 729 c.729C>G synonymous_variant 0.32 isoniazid Not assoc w R - Interim
dnaA 741 c.741T>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 753 c.753C>A synonymous_variant 0.32 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.31 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.33 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.35 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 798 c.798C>T synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.3 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.34 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.32 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.31 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.31 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.31 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.3 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.32 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.38 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.36 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.31 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.18 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.22 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.23 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.25 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>G synonymous_variant 0.27 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.26 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.22 isoniazid
dnaA 1312 c.1312_1314delCGAinsAG frameshift_variant&synonymous_variant 0.2 isoniazid Uncertain significance
dnaA 1317 c.1317A>T synonymous_variant 0.21 isoniazid
gyrB 6100 c.861G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6103 c.864G>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrB 6123 p.Ala295Gly missense_variant 0.34 levofloxacin
moxifloxacin
gyrB 6127 c.888G>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6130 c.891T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6142 c.903G>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6196 c.957C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrB 6215 p.Ser326Thr missense_variant 0.35 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6571 c.-731T>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6583 c.-719G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6586 c.-716T>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6619 c.-683T>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>T upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.42 levofloxacin Uncertain significance
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.43 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.3 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6838 c.-464C>T upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6853 c.-449A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6866 c.-436C>T upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6889 c.-413G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>A upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7000 c.-302C>T upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7021 c.-281G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 7030 c.-272C>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7442 c.141G>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7502 c.201C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7514 c.213C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7538 c.237G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7556 c.255C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 7727 c.426G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 7733 c.432A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7769 c.468C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7778 c.477G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8103 p.Ser268Ala missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8327 c.1026C>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.48 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8552 c.1251C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8642 c.1341A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8783 c.1482G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8817 p.Ser506Ala missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8822 c.1521C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8843 c.1542G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8849 c.1548C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8885 c.1584C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.44 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.45 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9002 c.1701C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9362 c.2061C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9365 c.2064G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
Rv0010c 13860 c.-302A>G upstream_gene_variant 0.25 isoniazid
Rv0010c 13864 c.-306A>C upstream_gene_variant 0.31 isoniazid
Rv0010c 13876 c.-318G>C upstream_gene_variant 0.34 isoniazid
Rv0010c 13890 c.-332T>C upstream_gene_variant 0.42 isoniazid
Rv0010c 13893 c.-335T>G upstream_gene_variant 0.44 isoniazid
Rv0010c 13903 c.-345A>G upstream_gene_variant 0.53 isoniazid
fgd1 490797 c.15G>A synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 490800 c.18A>C synonymous_variant 0.44 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490803 c.21T>A synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490812 c.30A>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490818 c.36C>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fgd1 490854 c.72C>T synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 490872 c.90C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 490929 c.147C>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 490932 c.150T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490947 c.165G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 490971 c.189A>G synonymous_variant 0.48 clofazimine
pretomanid
delamanid
fgd1 490974 c.192T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490980 p.Asn66Lys missense_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490981 c.199C>A synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490987 p.Leu69Val missense_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490998 c.216T>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fgd1 491007 c.225G>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491560 p.His260Thr missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491569 p.Asp263His missense_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491603 p.Ala274Glu missense_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.42 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575536 c.189T>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575542 c.195C>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575561 p.Met72Val missense_variant 0.3 ethionamide
isoniazid
mshA 575569 c.222A>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575571 p.Ser75Thr missense_variant 0.27 ethionamide
isoniazid
mshA 575587 c.240C>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575590 c.243T>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575593 c.246G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575617 c.270C>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575623 c.276C>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575704 c.357T>C synonymous_variant 0.41 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.44 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.55 ethionamide
isoniazid
mshA 575725 c.378C>T synonymous_variant 0.48 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.52 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.52 ethionamide
isoniazid
mshA 575746 c.399C>T synonymous_variant 0.46 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.42 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.41 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.41 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.39 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.39 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.28 ethionamide
isoniazid
mshA 575833 c.486C>T synonymous_variant 0.24 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575845 c.498C>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575878 c.531A>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.85 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 619543 c.-348C>G upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619558 c.-333G>C upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619594 c.-297G>C upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 619618 c.-273C>G upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>G upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620175 c.285C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620198 p.Gln103Leu missense_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620226 c.336G>A synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.29 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 656534 p.Arg313Gly missense_variant 0.25 ethionamide
Rv0565c 656538 p.Ser311Ala missense_variant 0.24 ethionamide
Rv0565c 656568 c.903G>C synonymous_variant 0.33 ethionamide
Rv0565c 656582 p.Leu297Met missense_variant 0.31 ethionamide
Rv0565c 656583 c.888A>G synonymous_variant 0.31 ethionamide
Rv0565c 656589 c.882T>C synonymous_variant 0.32 ethionamide
Rv0565c 656604 c.867G>C synonymous_variant 0.3 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.95 ethionamide Uncertain significance
Rv0565c 657653 c.-183C>G upstream_gene_variant 0.26 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.26 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.26 ethionamide
Rv0565c 657686 c.-216C>A upstream_gene_variant 0.26 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.26 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.4 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.37 ethionamide
hadA 731774 c.-156T>C upstream_gene_variant 0.22 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.27 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.32 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.27 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.24 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.26 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.28 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.27 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.28 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.32 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.5 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.45 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.48 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.48 isoniazid
nusG 734093 c.-161A>C upstream_gene_variant 0.36 rifampicin
nusG 734102 c.-152G>C upstream_gene_variant 0.43 rifampicin
nusG 734111 c.-143A>G upstream_gene_variant 0.42 rifampicin
nusG 734114 c.-140A>G upstream_gene_variant 0.4 rifampicin
nusG 734120 c.-134T>C upstream_gene_variant 0.38 rifampicin Uncertain significance
nusG 734123 c.-131C>T upstream_gene_variant 0.33 rifampicin
nusG 734129 c.-125G>C upstream_gene_variant 0.35 rifampicin
nusG 734132 c.-122G>C upstream_gene_variant 0.34 rifampicin
nusG 734135 c.-119G>T upstream_gene_variant 0.36 rifampicin
nusG 734144 c.-110G>T upstream_gene_variant 0.34 rifampicin
nusG 734147 c.-107T>C upstream_gene_variant 0.31 rifampicin
nusG 734370 c.117A>G synonymous_variant 0.2 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.31 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.36 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.38 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.53 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.59 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.41 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.37 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.36 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.29 rifampicin
nusG 734596 c.343_345delTTGinsCC frameshift_variant&missense_variant 0.28 rifampicin
nusG 734604 c.351C>T synonymous_variant 0.32 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.35 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.32 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.29 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.28 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.28 rifampicin
nusG 734646 c.393G>C synonymous_variant 0.28 rifampicin
nusG 734652 c.399T>G synonymous_variant 0.25 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.27 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.26 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.31 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.33 rifampicin Uncertain significance
nusG 734814 c.561G>C synonymous_variant 0.41 rifampicin
nusG 734826 c.573A>G synonymous_variant 0.35 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734841 c.588G>C synonymous_variant 0.4 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.36 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.3 rifampicin
rpoB 760067 c.261G>C synonymous_variant 0.22 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.22 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.33 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.44 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.44 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.47 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.36 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.44 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.42 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.44 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.42 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.49 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.47 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.49 rifampicin
rpoB 760403 c.597C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.59 rifampicin
rpoB 760520 c.714C>G synonymous_variant 0.57 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.58 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.42 rifampicin
rpoB 760547 c.741G>T synonymous_variant 0.46 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.4 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.39 rifampicin
rpoB 760598 c.792C>T synonymous_variant 0.41 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.44 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.36 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.36 rifampicin
rpoB 760765 p.Glu320Ala missense_variant 0.38 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.37 rifampicin
rpoB 760841 c.1035T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.28 rifampicin
rpoB 760856 c.1050C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.24 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.21 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.27 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.36 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.33 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.37 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.32 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.33 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.54 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.54 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.6 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.37 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.37 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761361 c.1555_1556delAGinsTC synonymous_variant 0.33 rifampicin
rpoB 761373 p.Val523His missense_variant 0.33 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.19 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.38 rifampicin
rpoB 761504 c.1698C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.45 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.48 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.48 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761603 c.1797C>G synonymous_variant 0.35 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.34 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.19 rifampicin
rpoB 761660 c.1854G>A synonymous_variant 0.17 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.23 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.22 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.22 rifampicin
rpoB 761825 c.2019C>T synonymous_variant 0.22 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.2 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.22 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.24 rifampicin
rpoB 761867 c.2061C>G synonymous_variant 0.27 rifampicin
rpoB 761870 p.Asp688Glu missense_variant 0.27 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.29 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.29 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.29 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.31 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.31 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.31 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.31 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.38 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.48 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.48 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.46 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762074 c.2268C>G synonymous_variant 0.44 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.39 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.33 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.27 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.48 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.48 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.49 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.45 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.43 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.44 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.46 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.44 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.48 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.4 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762476 c.-894C>A upstream_gene_variant 0.36 rifampicin
rpoB 762489 p.Val895Gln missense_variant 0.33 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.36 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.36 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.3 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.3 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.32 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 0.32 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.3 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 762863 c.-507T>G upstream_gene_variant 0.38 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.35 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.47 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.47 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.58 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.47 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.49 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.5 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>C upstream_gene_variant 0.33 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.29 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.29 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.3 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.43 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.46 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.56 rifampicin
rpoC 763501 c.132C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.39 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.38 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.35 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.38 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.38 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.38 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.32 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.24 rifampicin
rpoC 763852 c.483C>G synonymous_variant 0.28 rifampicin
rpoC 763853 c.484_486delGTCinsAT frameshift_variant&missense_variant 0.29 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.29 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.34 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.41 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.44 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.52 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.5 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763930 c.561G>A synonymous_variant 0.4 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.34 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.2 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.19 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.22 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.34 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.39 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.43 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.42 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764198 c.829C>T synonymous_variant 0.48 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.44 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764213 p.Arg282Lys missense_variant 0.41 rifampicin Uncertain significance
rpoC 764257 c.888G>C synonymous_variant 0.46 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.43 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.48 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.55 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.31 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 764428 c.1059G>A synonymous_variant 0.39 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.43 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.41 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.42 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.42 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.42 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.52 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.56 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.53 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.51 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.51 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.47 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.43 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.49 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.5 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.33 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>T synonymous_variant 0.28 rifampicin
rpoC 765055 c.1686C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765300 p.Val644Ala missense_variant 0.32 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.38 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.38 rifampicin Uncertain significance
rpoC 765370 c.2001G>T synonymous_variant 0.41 rifampicin
rpoC 765371 c.2002C>T synonymous_variant 0.41 rifampicin
rpoC 765379 c.2010G>T synonymous_variant 0.43 rifampicin
rpoC 765383 c.2014_2016delATGinsCT frameshift_variant&missense_variant 0.43 rifampicin
rpoC 765394 c.2025G>A synonymous_variant 0.45 rifampicin
rpoC 765404 c.2035_2037delCTGinsGC frameshift_variant&missense_variant 0.33 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.33 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.36 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.44 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.53 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.5 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.53 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.53 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.5 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.52 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.32 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.26 rifampicin
rpoC 765646 c.2277G>A synonymous_variant 0.31 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.32 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.3 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.3 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.32 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.33 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.36 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.41 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.44 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.47 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.46 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>G synonymous_variant 0.42 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.3 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.33 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.35 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.26 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.24 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.25 rifampicin
rpoC 766080 c.2712_2715delTGCA frameshift_variant 0.24 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.31 rifampicin
rpoC 766097 p.Leu910Val missense_variant 0.33 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.3 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.23 rifampicin
rpoC 766148 p.Thr927Ala missense_variant 0.24 rifampicin Uncertain significance
rpoC 766273 c.2904T>C synonymous_variant 0.18 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.18 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.29 rifampicin
rpoC 766294 c.2925C>T synonymous_variant 0.39 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766309 c.2940G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>C synonymous_variant 0.45 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.46 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.43 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.46 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.49 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.43 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.42 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.42 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.42 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.41 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.4 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.4 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.46 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.47 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.44 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.44 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.47 rifampicin
rpoC 766522 c.3153C>T synonymous_variant 0.54 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.54 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.51 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.48 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.32 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.3 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.3 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.3 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.43 rifampicin
rpoC 766618 c.3249G>C synonymous_variant 0.38 rifampicin
rpoC 766621 c.3252G>A synonymous_variant 0.4 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.56 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.56 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.58 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.58 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.52 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.55 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.62 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.43 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.24 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.33 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.36 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.35 rifampicin
rpoC 767065 c.3696G>A synonymous_variant 0.36 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767102 c.3733_3735delCTCinsTG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.29 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.32 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.44 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.28 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.31 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775909 p.Leu858Phe missense_variant 0.31 clofazimine
bedaquiline
mmpL5 775913 c.2568C>G synonymous_variant 0.31 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 0.32 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.44 clofazimine
bedaquiline
mmpL5 775975 c.2506T>C synonymous_variant 0.41 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.39 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpL5 777170 c.1311T>C synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 777173 c.1308C>G synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.21 clofazimine
bedaquiline
mmpL5 777188 c.1293T>C synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 777191 c.1290C>T synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 777194 c.1287A>G synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 777200 c.1281C>G synonymous_variant 0.23 clofazimine
bedaquiline
mmpL5 777203 c.1278G>C synonymous_variant 0.22 clofazimine
bedaquiline
mmpL5 777206 c.1275A>G synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 777212 c.1269C>G synonymous_variant 0.26 clofazimine
bedaquiline
mmpL5 777215 c.1266C>G synonymous_variant 0.27 clofazimine
bedaquiline
mmpL5 777218 c.1263G>A synonymous_variant 0.28 clofazimine
bedaquiline
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.33 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.38 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.46 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.54 streptomycin
rpsL 781718 c.159C>T synonymous_variant 0.57 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.56 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.53 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.52 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.5 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.49 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.47 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.49 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.47 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.47 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.5 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.46 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.45 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.44 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.44 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.44 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.55 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.5 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.39 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.46 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.41 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.42 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.38 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.38 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.4 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.41 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.46 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.38 linezolid
rplC 800703 c.-106_-104delTTGinsCC upstream_gene_variant 0.36 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.4 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.38 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.35 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.38 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.32 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.26 linezolid
rplC 801147 c.339T>C synonymous_variant 0.25 linezolid
rplC 801150 c.342G>C synonymous_variant 0.27 linezolid
rplC 801156 c.348T>C synonymous_variant 0.32 linezolid
rplC 801171 c.363A>G synonymous_variant 0.42 linezolid
rplC 801174 c.366T>C synonymous_variant 0.44 linezolid
rplC 801195 c.387G>C synonymous_variant 0.59 linezolid
rplC 801222 c.414T>C synonymous_variant 0.68 linezolid
rplC 801249 c.441T>C synonymous_variant 0.66 linezolid
rplC 801255 c.447C>T synonymous_variant 0.62 linezolid
rplC 801267 c.459A>T synonymous_variant 0.57 linezolid
rplC 801270 c.462T>C synonymous_variant 0.52 linezolid
rplC 801276 c.468G>C synonymous_variant 0.48 linezolid
rplC 801282 c.474G>C synonymous_variant 0.48 linezolid
rplC 801307 c.499_501delGCCinsTG frameshift_variant&missense_variant 0.41 linezolid
rplC 801312 c.504G>C synonymous_variant 0.36 linezolid
rplC 801321 c.513C>T synonymous_variant 0.33 linezolid Not assoc w R - Interim
rplC 801323 p.Asn172Ser missense_variant 0.32 linezolid
rplC 801330 c.522G>C synonymous_variant 0.33 linezolid
rplC 801339 c.531T>C synonymous_variant 0.3 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.29 linezolid
rplC 801348 c.540T>G synonymous_variant 0.35 linezolid
rplC 801357 c.549T>C synonymous_variant 0.38 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.35 linezolid
rplC 801402 c.594T>C synonymous_variant 0.24 linezolid
rplC 801405 c.597T>C synonymous_variant 0.24 linezolid
rplC 801417 c.609T>C synonymous_variant 0.24 linezolid
rplC 801423 c.615G>C synonymous_variant 0.24 linezolid
rplC 801427 p.Met207Val missense_variant 0.25 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303239 c.309C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303242 c.312T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303263 c.333G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303272 c.342A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303281 c.351A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303455 c.525C>G synonymous_variant 0.3 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303464 c.534A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303480 p.Gln184Glu missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303488 c.558G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303492 c.562T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>T synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303647 c.717G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303653 c.723G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Thr missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303890 c.960G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303897 c.967C>T synonymous_variant 0.46 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303908 c.978C>A synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303932 c.1002G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303935 c.1005G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304161 p.Arg411Ala missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304169 c.1239T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304173 p.Val415Thr missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304625 c.1695C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304796 c.1866G>A synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304880 c.1950C>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304995 c.2065T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305014 p.Thr695Ser missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>A synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305039 c.2109G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305096 c.2166T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305114 c.2184T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>C synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305144 c.2214G>A synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305195 c.2265T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305199 p.Ala757Ser missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305204 c.2274C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305215 p.Ser762Thr missense_variant 0.2 clofazimine
pretomanid
delamanid
sigE 1365018 c.606G>C synonymous_variant 0.18 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1460804 c.-241T>C upstream_gene_variant 0.26 bedaquiline
atpE 1460816 c.-229T>C upstream_gene_variant 0.26 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.34 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.31 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.33 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.34 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.34 bedaquiline
atpE 1460879 c.-166C>G upstream_gene_variant 0.21 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.22 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.24 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.24 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473936 n.279A>G non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.47 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.63 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
fabG1 1673641 p.Val68Ile missense_variant 0.19 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.17 ethionamide
isoniazid
fabG1 1674037 p.Gln200Ala missense_variant 0.23 ethionamide
isoniazid
fabG1 1674049 c.610_612delCAAinsGC frameshift_variant&missense_variant 0.27 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1674060 c.-142A>C upstream_gene_variant 0.3 ethionamide
isoniazid
inhA 1674078 c.-124C>G upstream_gene_variant 0.37 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.38 ethionamide
isoniazid
inhA 1674084 c.-118C>G upstream_gene_variant 0.38 ethionamide
isoniazid
inhA 1674114 c.-88T>G upstream_gene_variant 0.24 ethionamide
isoniazid
inhA 1674123 c.-79T>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674540 c.339C>T synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.29 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.26 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.38 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.33 ethionamide
isoniazid
inhA 1674624 c.423A>T synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.46 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.46 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674729 c.528G>T synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674746 p.Tyr182Phe missense_variant 0.29 ethionamide
isoniazid
inhA 1674756 c.555T>A synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674858 c.657G>A synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.28 ethionamide
isoniazid
inhA 1674934 c.733C>T synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674939 c.738G>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674954 c.753G>T synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674960 c.759C>G synonymous_variant 0.22 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.2 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.4 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.42 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.4 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1833793 c.252C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.39 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.47 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.49 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.4 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.36 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.38 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.33 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.39 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.67 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.59 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.56 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.45 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.5 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.49 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.56 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
rpsA 1834546 c.1005T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.51 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.55 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.56 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.24 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.34 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.36 linezolid
tsnR 1853375 c.-231G>T upstream_gene_variant 0.39 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.39 linezolid
tsnR 1853390 c.-216G>A upstream_gene_variant 0.4 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.4 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.35 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.32 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.31 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917951 c.12T>C synonymous_variant 0.23 capreomycin
tlyA 1917981 c.42G>C synonymous_variant 0.32 capreomycin
tlyA 1917990 c.51G>C synonymous_variant 0.29 capreomycin
tlyA 1917993 c.54A>G synonymous_variant 0.31 capreomycin Not assoc w R - Interim
tlyA 1917996 c.57A>C synonymous_variant 0.3 capreomycin
tlyA 1918002 c.63A>G synonymous_variant 0.37 capreomycin
tlyA 1918212 c.273A>G synonymous_variant 0.26 capreomycin
tlyA 1918218 c.279C>G synonymous_variant 0.24 capreomycin
tlyA 1918224 c.285G>C synonymous_variant 0.25 capreomycin
ndh 2101912 c.1131G>C synonymous_variant 0.33 ethionamide
delamanid
isoniazid
ndh 2101915 c.1128T>C synonymous_variant 0.35 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101920 c.1123A>C synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2101921 c.1122G>C synonymous_variant 0.37 ethionamide
delamanid
isoniazid
ndh 2101924 c.1119T>G synonymous_variant 0.38 ethionamide
delamanid
isoniazid
ndh 2101930 c.1113C>G synonymous_variant 0.36 ethionamide
delamanid
isoniazid
ndh 2101936 c.1107G>C synonymous_variant 0.34 ethionamide
delamanid
isoniazid
ndh 2101939 c.1104A>C synonymous_variant 0.33 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.33 ethionamide
delamanid
isoniazid
ndh 2101966 c.1077T>C synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2101969 p.Glu358Asp missense_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2102218 c.825C>G synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102233 c.810G>A synonymous_variant 0.21 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102260 c.783C>T synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102266 c.777C>G synonymous_variant 0.34 ethionamide
delamanid
isoniazid
ndh 2102317 c.726A>G synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102328 p.Leu239Met missense_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102623 c.420C>G synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102632 c.411C>G synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2102638 c.405A>G synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102644 c.399A>G synonymous_variant 0.33 ethionamide
delamanid
isoniazid
ndh 2102671 c.372T>G synonymous_variant 0.39 ethionamide
delamanid
isoniazid
ndh 2102680 c.363T>G synonymous_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2102683 c.360T>C synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2102686 c.357G>C synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2102694 p.Val117Ile missense_variant 0.36 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102701 c.342C>T synonymous_variant 0.35 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155641 p.Lys157Asn missense_variant 0.28 isoniazid Uncertain significance
katG 2155680 c.432G>C synonymous_variant 0.28 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.25 isoniazid
katG 2155692 c.420C>T synonymous_variant 0.24 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.24 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.24 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.24 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.24 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.24 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.56 isoniazid
kasA 2517926 c.-189G>A upstream_gene_variant 0.58 isoniazid
kasA 2517950 c.-165C>T upstream_gene_variant 0.5 isoniazid
kasA 2517965 c.-150C>T upstream_gene_variant 0.45 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.41 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.33 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.31 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.21 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.18 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.26 isoniazid
kasA 2518152 p.Ser13Asn missense_variant 0.28 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.32 isoniazid
kasA 2518168 c.54C>T synonymous_variant 0.29 isoniazid
kasA 2518172 c.58_60delACAinsGG frameshift_variant&missense_variant 0.3 isoniazid
kasA 2518183 c.69G>A synonymous_variant 0.41 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.4 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.4 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.35 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.23 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.21 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.21 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.22 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.22 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.25 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.26 isoniazid
kasA 2518621 c.507G>T synonymous_variant 0.26 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.37 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.4 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.5 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.52 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.53 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.53 isoniazid
kasA 2518696 c.582C>T synonymous_variant 0.52 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.49 isoniazid
kasA 2518705 c.591T>G synonymous_variant 0.47 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.49 isoniazid
kasA 2518714 c.600A>T synonymous_variant 0.49 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.49 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.45 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.4 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.41 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.43 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.42 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.42 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.4 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.33 isoniazid
kasA 2518837 c.723G>A synonymous_variant 0.32 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.32 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.28 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.31 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.26 isoniazid
kasA 2518867 c.753G>A synonymous_variant 0.26 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.21 isoniazid
ahpC 2726633 c.441C>G synonymous_variant 0.29 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.25 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.25 isoniazid
ahpC 2726651 c.459G>C synonymous_variant 0.26 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.31 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.24 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.25 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
ahpC 2726684 c.492G>C synonymous_variant 0.23 isoniazid
ahpC 2726687 c.495C>G synonymous_variant 0.25 isoniazid
ahpC 2726693 c.501C>A synonymous_variant 0.24 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.23 isoniazid
folC 2746285 c.1314T>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2746308 p.Arg431Ser missense_variant 0.25 para-aminosalicylic_acid
folC 2746321 c.1278A>G synonymous_variant 0.28 para-aminosalicylic_acid
folC 2746335 p.Gly422Arg missense_variant 0.23 para-aminosalicylic_acid
folC 2746336 c.1263C>G synonymous_variant 0.22 para-aminosalicylic_acid
folC 2746584 c.1015T>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2746594 c.1005T>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747059 c.540T>C synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747086 c.513A>C synonymous_variant 0.3 para-aminosalicylic_acid
folC 2747089 c.510G>C synonymous_variant 0.3 para-aminosalicylic_acid
folC 2747101 c.498G>C synonymous_variant 0.28 para-aminosalicylic_acid
folC 2747107 c.492G>C synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747110 c.489T>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747113 c.486C>G synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747116 c.483G>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747131 c.468C>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747134 c.465C>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747314 c.285A>T synonymous_variant 0.3 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.3 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.26 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.23 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.24 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747442 c.157T>C synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747467 p.Asp44Glu missense_variant 0.21 para-aminosalicylic_acid
Rv2477c 2782426 c.1617G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782432 c.1609_1611delGTGinsAC frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782453 c.1590C>T synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782651 c.1392T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782669 c.1374A>G synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782680 c.1363T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782684 c.1359T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782705 c.1338G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782708 c.1335C>T synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782714 c.1329A>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782720 c.1323T>A synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782729 c.1314A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782732 c.1311A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782738 c.1305C>T synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782750 c.1293T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782759 c.1284A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782913 p.Ser377Ile missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Gln missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.49 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.53 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.47 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783086 c.957C>T synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783116 c.927T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.39 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.4 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783193 p.Ser284Gly missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783244 p.Thr267Ala missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783305 c.738G>A synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTC frameshift_variant&missense_variant 0.39 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783629 c.414C>T synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>A synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783680 c.363G>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783695 c.348C>T synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.58 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.58 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.56 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783950 c.93C>T synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.48 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.47 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859918 c.501A>G synonymous_variant 0.24 clofazimine
bedaquiline
pepQ 2859921 c.498C>G synonymous_variant 0.23 clofazimine
bedaquiline
pepQ 2859945 c.474G>A synonymous_variant 0.18 clofazimine
bedaquiline
Rv2752c 3065532 c.660A>G synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065553 c.639A>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065562 c.630T>C synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065568 p.Ile208His missense_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065612 p.Thr194Ala missense_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065625 c.567G>C synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065886 c.306C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065901 c.291A>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065916 c.276T>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065919 c.273G>C synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065925 p.Ala89Gly missense_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065928 c.264G>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065946 p.Gly82Ala missense_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065955 c.235_237delTTGinsCC frameshift_variant&missense_variant 0.39 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065979 c.213T>C synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065988 p.Glu68Ser missense_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.3 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065997 c.195C>T synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066003 c.189C>T synonymous_variant 0.29 ethambutol
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin
isoniazid
Rv2752c 3066024 c.168T>G synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066118 p.Asn25Ser missense_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066498 c.-307C>A upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066734 c.-543G>A upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066741 c.-550T>C upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066744 c.-553C>T upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066747 c.-558_-556delCAAinsATC upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066756 c.-567_-565delCGGinsAC upstream_gene_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.43 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066780 c.-589C>G upstream_gene_variant 0.43 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066783 c.-592G>C upstream_gene_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066798 c.-607G>C upstream_gene_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067277 c.669C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067284 p.Ala221Gly missense_variant 0.29 para-aminosalicylic_acid
thyX 3067286 c.660C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067304 c.642A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067313 c.633G>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067319 c.627G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067811 c.135G>A synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067838 c.108C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.3 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067877 c.69G>A synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3073889 p.Ser195Ala missense_variant 0.24 para-aminosalicylic_acid
thyA 3073890 c.580_582delTTGinsCC frameshift_variant&missense_variant 0.24 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.24 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073920 c.550_552delCTCinsTG frameshift_variant&synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.43 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074120 c.352T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074121 c.351T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074124 c.348G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074142 c.330C>T synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3623380 p.Ala511Thr missense_variant 0.18 bedaquiline
rifampicin
lpqB 3623404 p.Ile503Leu missense_variant 0.25 bedaquiline
rifampicin
lpqB 3623408 c.1503C>T synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623411 c.1500T>G synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3623417 c.1494A>C synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3623428 c.1483T>C synonymous_variant 0.36 bedaquiline
rifampicin
lpqB 3623441 p.Ser490Asn missense_variant 0.3 bedaquiline
rifampicin
lpqB 3623444 c.1467T>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3623465 c.1446G>C synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3623468 c.1443T>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623472 p.Tyr480Phe missense_variant 0.28 bedaquiline
rifampicin
lpqB 3623479 c.1432C>T synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3623480 c.1431C>G synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3623484 p.Phe476Tyr missense_variant 0.26 bedaquiline
rifampicin
lpqB 3623492 c.1419T>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624077 c.834G>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624082 c.829A>C synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624089 c.822C>G synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624094 c.817A>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624100 c.811T>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624116 c.795A>G synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624119 c.792C>G synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.36 bedaquiline
rifampicin
lpqB 3624133 c.778A>C synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624166 p.Met249Leu missense_variant 0.3 bedaquiline
rifampicin
lpqB 3624389 c.522C>G synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624404 c.507G>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3624422 c.489G>C synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624425 p.Glu162Ser missense_variant 0.23 bedaquiline
rifampicin
lpqB 3624428 c.483A>G synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624452 c.459T>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624455 c.456G>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624656 c.255C>T synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.24 bedaquiline
rifampicin Uncertain significance
lpqB 3624770 c.141T>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624776 c.135T>C synonymous_variant 0.22 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625240 c.-330T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625243 c.-333T>G upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625246 c.-336G>A upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625255 c.-345T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625258 c.-348G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3625313 p.Arg434Lys missense_variant 0.47 bedaquiline
rifampicin
mtrB 3625321 c.1293A>G synonymous_variant 0.4 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625327 c.-417A>G upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3625572 p.Thr348Ser missense_variant 0.27 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.33 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.38 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.34 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625687 c.-777G>T upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625702 c.-792C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625741 c.-831G>A upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.34 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625806 c.808A>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625852 c.762A>G synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625888 c.726G>A synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625909 c.-999T>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626077 c.537C>G synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3626083 c.531G>A synonymous_variant 0.25 bedaquiline
rifampicin
mtrB 3626092 c.522T>G synonymous_variant 0.27 bedaquiline
rifampicin
mtrB 3626095 p.Glu173Asp missense_variant 0.29 bedaquiline
rifampicin
mtrB 3626101 p.Gln171His missense_variant 0.3 bedaquiline
rifampicin
mtrB 3626107 c.507G>C synonymous_variant 0.33 bedaquiline
rifampicin
mtrB 3626124 p.Ala164Ser missense_variant 0.32 bedaquiline
rifampicin
mtrB 3626125 c.489C>G synonymous_variant 0.32 bedaquiline
rifampicin
mtrB 3626134 c.480C>G synonymous_variant 0.33 bedaquiline
rifampicin
mtrB 3626137 c.477G>A synonymous_variant 0.35 bedaquiline
rifampicin
mtrB 3626157 p.Ala153Ser missense_variant 0.35 bedaquiline
rifampicin
mtrB 3626158 p.Asn152Ser missense_variant 0.35 bedaquiline
rifampicin
mtrB 3626170 c.444T>C synonymous_variant 0.32 bedaquiline
rifampicin
mtrB 3626325 p.Thr97Ala missense_variant 0.42 bedaquiline
rifampicin
mtrB 3626329 c.285G>A synonymous_variant 0.43 bedaquiline
rifampicin
mtrB 3626332 c.282T>C synonymous_variant 0.42 bedaquiline
rifampicin
mtrB 3626349 p.Ser89Gly missense_variant 0.44 bedaquiline
rifampicin
mtrB 3626350 c.264C>G synonymous_variant 0.46 bedaquiline
rifampicin
mtrB 3626377 p.Asp79Glu missense_variant 0.41 bedaquiline
rifampicin
mtrB 3626383 c.231G>C synonymous_variant 0.42 bedaquiline
rifampicin
mtrB 3626386 c.228G>C synonymous_variant 0.4 bedaquiline
rifampicin
mtrB 3626390 p.Arg75Lys missense_variant 0.39 bedaquiline
rifampicin
mtrB 3626400 p.Ile72Val missense_variant 0.29 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626735 c.-122C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626744 c.-131G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626849 c.-236C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626959 c.-346C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627083 c.-470G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.162A>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
fbiB 3642581 c.1047A>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiB 3642587 p.Met351Ile missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiB 3642602 c.1068A>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiB 3642605 c.1071A>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642609 p.Ser359Ala missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642614 c.1080C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiB 3642620 c.1086T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642662 c.1128C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiB 3642668 c.1134A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642680 c.1146A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642695 c.1161G>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
rpoA 3877494 p.Glu338Asp missense_variant 0.24 rifampicin Uncertain significance
rpoA 3877503 c.1003_1005delGCGinsTC frameshift_variant&missense_variant 0.23 rifampicin
rpoA 3877506 p.Gly334Ala missense_variant 0.21 rifampicin
rpoA 3877513 p.Thr332Ser missense_variant 0.26 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.26 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.33 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.35 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.39 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.35 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.48 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.44 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>G synonymous_variant 0.41 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.48 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.44 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.42 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Asn missense_variant 0.34 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.27 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878118 c.390T>C synonymous_variant 0.27 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.27 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.35 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>G synonymous_variant 0.27 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.29 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.38 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.35 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.33 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.29 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.27 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.32 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.34 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.33 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.32 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.27 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.29 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.3 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.31 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.33 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.32 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.31 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.38 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.33 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.29 rifampicin
rpoA 3878836 c.-330_-329delAGinsGC upstream_gene_variant 0.29 rifampicin
rpoA 3878845 c.-338G>T upstream_gene_variant 0.3 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.32 rifampicin
rpoA 3878862 c.-355T>C upstream_gene_variant 0.34 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.4 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878935 c.-428C>T upstream_gene_variant 0.39 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.39 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878950 c.-443C>T upstream_gene_variant 0.39 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.32 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.23 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.34 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.33 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.39 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.41 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.42 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.44 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.47 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.42 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.45 rifampicin
rpoA 3879202 c.-695T>C upstream_gene_variant 0.39 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.29 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.26 rifampicin
ddn 3986633 c.-211C>T upstream_gene_variant 0.48 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.48 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.46 delamanid
pretomanid
ddn 3986651 c.-193G>A upstream_gene_variant 0.47 delamanid
pretomanid
ddn 3986657 c.-187C>G upstream_gene_variant 0.43 delamanid
pretomanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.38 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.38 delamanid
pretomanid
ddn 3986690 c.-154C>G upstream_gene_variant 0.29 delamanid
pretomanid
ddn 3986696 c.-148G>C upstream_gene_variant 0.26 delamanid
pretomanid
clpC1 4038239 c.2466T>A synonymous_variant 0.25 pyrazinamide
clpC1 4038255 p.Val817Lys missense_variant 0.22 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038289 p.Asn806Asp missense_variant 0.27 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038308 c.2397G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.31 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.42 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038486 p.Gly740Thr missense_variant 0.36 pyrazinamide
clpC1 4038488 c.2217C>G synonymous_variant 0.38 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038498 p.Ser736Asn missense_variant 0.54 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.62 pyrazinamide
clpC1 4038533 p.Arg724Lys missense_variant 0.64 pyrazinamide
clpC1 4038587 c.2118C>T synonymous_variant 0.56 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.48 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.42 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.42 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.43 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.44 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.43 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.38 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.39 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.46 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.39 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.38 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.44 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4039010 c.1695G>A synonymous_variant 0.51 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039025 c.1680C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 0.43 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.52 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.49 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.44 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.41 pyrazinamide
clpC1 4039199 c.1506C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039364 c.1341C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.28 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.35 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039508 c.1197G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.42 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.45 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.21 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.44 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.42 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.48 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.44 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.41 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.47 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.51 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.59 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.49 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.56 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.36 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.38 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.25 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.29 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.41 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.39 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.35 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.27 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040330 c.375C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.22 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.23 pyrazinamide
panD 4044084 c.198T>C synonymous_variant 0.29 pyrazinamide
panD 4044093 c.189A>G synonymous_variant 0.29 pyrazinamide
panD 4044096 c.186C>T synonymous_variant 0.3 pyrazinamide
panD 4044120 c.162A>G synonymous_variant 0.36 pyrazinamide
panD 4044123 c.159T>C synonymous_variant 0.37 pyrazinamide
panD 4044126 c.156T>C synonymous_variant 0.37 pyrazinamide
panD 4044135 c.147C>T synonymous_variant 0.42 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>C synonymous_variant 0.41 pyrazinamide
panD 4044162 c.120A>G synonymous_variant 0.36 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.39 pyrazinamide
panD 4044174 c.108C>G synonymous_variant 0.35 pyrazinamide
panD 4044237 c.45G>C synonymous_variant 0.25 pyrazinamide
panD 4044240 c.42G>C synonymous_variant 0.24 pyrazinamide
glpK 4138565 c.1191G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138667 c.1089G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138682 c.1074C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138695 p.Pro354Asp missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139242 c.514T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139243 c.513A>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139249 c.507C>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139270 c.486C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139273 c.483A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139552 c.202_204delGCGinsTC frameshift_variant&missense_variant 0.44 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139567 c.189C>T synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139581 p.Asn59Asp missense_variant 0.33 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139627 c.129G>A synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139630 c.126C>T synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239336 c.-527T>C upstream_gene_variant 0.27 ethambutol
embC 4239344 c.-519G>C upstream_gene_variant 0.26 ethambutol
embC 4239350 c.-513G>C upstream_gene_variant 0.29 ethambutol
embC 4239377 c.-486C>T upstream_gene_variant 0.3 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.32 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.32 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.41 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.37 ethambutol Not assoc w R
embC 4240693 c.831T>C synonymous_variant 0.26 ethambutol
embC 4240698 p.Ala279Gly missense_variant 0.31 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.43 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.46 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.47 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.41 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.47 ethambutol
embC 4240859 p.Leu333Val missense_variant 0.44 ethambutol
embC 4240867 c.1005T>A synonymous_variant 0.44 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.36 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.38 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.4 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.37 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.36 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.4 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.36 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.31 ethambutol
embC 4240951 c.1089C>G synonymous_variant 0.26 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.23 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.21 ethambutol
embC 4240966 c.1104G>C synonymous_variant 0.19 ethambutol
embC 4240978 c.1116G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240979 p.Thr373Gln missense_variant 0.18 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.2 ethambutol
embC 4240990 c.1128A>C synonymous_variant 0.26 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.32 ethambutol
embC 4241020 c.1158G>C synonymous_variant 0.31 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.31 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.38 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.38 ethambutol
embC 4241048 c.1186_1188delCTTinsTG frameshift_variant&missense_variant 0.36 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.42 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.57 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.55 ethambutol
embC 4241129 c.1267C>T synonymous_variant 0.49 ethambutol
embC 4241140 c.1278A>C synonymous_variant 0.47 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.4 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.4 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.23 ethambutol
embC 4241407 c.1545A>G synonymous_variant 0.19 ethambutol
embC 4241411 p.Ile517Leu missense_variant 0.22 ethambutol
embC 4241656 c.1794G>A synonymous_variant 0.19 ethambutol
embC 4241657 p.Ser599Pro missense_variant 0.19 ethambutol
embC 4241719 c.1857G>C synonymous_variant 0.24 ethambutol
embC 4241741 c.1879_1881delGTCinsCG frameshift_variant&missense_variant 0.21 ethambutol
embC 4241750 p.Leu630Val missense_variant 0.19 ethambutol
embC 4241755 c.1893C>G synonymous_variant 0.18 ethambutol
embC 4241756 c.1894C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241770 c.1908T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4242171 p.Thr770Asn missense_variant 0.26 ethambutol
embC 4242179 p.Leu773Val missense_variant 0.28 ethambutol
embC 4242190 c.2328C>G synonymous_variant 0.3 ethambutol
embC 4242196 c.2334A>C synonymous_variant 0.31 ethambutol
embC 4242199 c.2337C>G synonymous_variant 0.3 ethambutol
embC 4242202 c.2340C>T synonymous_variant 0.3 ethambutol
embC 4242205 c.2343G>T synonymous_variant 0.29 ethambutol
embC 4242208 c.2346T>G synonymous_variant 0.3 ethambutol
embC 4242229 c.2367C>A synonymous_variant 0.26 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244298 p.Ser356Ala missense_variant 0.19 ethambutol
embA 4244309 c.1077C>G synonymous_variant 0.21 ethambutol
embA 4244312 c.1080T>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embA 4244315 c.1083G>C synonymous_variant 0.25 ethambutol
embA 4244324 c.1092T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embA 4244327 c.1095T>C synonymous_variant 0.29 ethambutol
embA 4244337 p.Leu369Val missense_variant 0.3 ethambutol
embA 4244340 c.1108_1110delTCCinsGG frameshift_variant&missense_variant 0.29 ethambutol Uncertain significance
embA 4244345 c.1113C>G synonymous_variant 0.29 ethambutol
embA 4244366 c.1134C>A synonymous_variant 0.27 ethambutol
embA 4245056 c.1824C>G synonymous_variant 0.24 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.23 ethambutol
embA 4245078 p.Trp616Val missense_variant 0.29 ethambutol
embA 4245083 c.1851A>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embA 4245101 c.1869G>C synonymous_variant 0.37 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.33 ethambutol
embA 4245143 c.1911C>T synonymous_variant 0.36 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.38 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.39 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.38 ethambutol
embA 4245198 p.Leu656Ala missense_variant 0.35 ethambutol
embA 4245206 c.1974A>C synonymous_variant 0.35 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.36 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.38 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.4 ethambutol Uncertain significance
embB 4245668 c.-846C>G upstream_gene_variant 0.2 ethambutol
embA 4245674 c.2442A>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4245680 c.-834G>A upstream_gene_variant 0.24 ethambutol
embA 4245693 c.2461_2463delATCinsGG frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
embA 4245707 c.2475C>T synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4245710 c.-804G>C upstream_gene_variant 0.21 ethambutol
embB 4245725 c.-789A>C upstream_gene_variant 0.19 ethambutol
embA 4245728 p.Leu832Phe missense_variant 0.19 ethambutol Uncertain significance
embB 4245737 c.-777A>C upstream_gene_variant 0.2 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.17 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.18 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.2 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.2 ethambutol
embB 4247437 c.924A>C synonymous_variant 0.31 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.38 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.37 ethambutol
embB 4247476 c.963C>T synonymous_variant 0.35 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.26 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.27 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.27 ethambutol
embB 4247544 p.Ser344Thr missense_variant 0.19 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.19 ethambutol
embB 4247857 c.1344C>A synonymous_variant 0.33 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.32 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.33 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.3 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4247908 c.1395C>T synonymous_variant 0.27 ethambutol
embB 4247909 c.1396T>C synonymous_variant 0.27 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247920 c.1407T>C synonymous_variant 0.28 ethambutol
embB 4247923 c.1410T>C synonymous_variant 0.3 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.37 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.39 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.22 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.24 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.24 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.19 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.23 ethambutol
aftB 4267607 c.1230G>A synonymous_variant 0.27 ethambutol
aftB 4267622 c.1215G>C synonymous_variant 0.26 ethambutol
aftB 4267625 c.1212T>C synonymous_variant 0.25 ethambutol
aftB 4267634 p.Arg401His missense_variant 0.27 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.75 ethambutol Not assoc w R
aftB 4267649 c.1188T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
aftB 4268441 c.396C>G synonymous_variant 0.21 ethambutol
aftB 4268444 c.393C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
aftB 4269027 c.-191C>A upstream_gene_variant 0.21 ethambutol
aftB 4269042 c.-206G>C upstream_gene_variant 0.19 ethambutol
ubiA 4269075 c.757_759delATTinsGG frameshift_variant&missense_variant 0.18 ethambutol
ubiA 4269091 p.Phe248Tyr missense_variant 0.19 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.42 ethambutol
aftB 4269210 c.-374G>A upstream_gene_variant 0.33 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407620 p.Tyr195His missense_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 0.95 streptomycin Not assoc w R