TB-Profiler result

Run: ERR752229
Summary

Run ID: ERR752229

Sample name:

Date: 2024-04-16T00:20:09.772779

Number of reads: 3377688

Percentage reads mapped: 70.26

Median coverage: 69.0

Strain: lineage4.5

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.5 Euro-American RD122 0.97
lineage4 Euro-American None 1.0
La1.7.1 M.bovis None 0.07
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
ofloxacin
levofloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrB 6738 p.Thr500Asn missense_variant 0.19 levofloxacin Uncertain significance Mutation from literature
moxifloxacin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1056 c.1056G>C synonymous_variant 0.13 isoniazid Not assoc w R - Interim
dnaA 1059 c.1059C>G synonymous_variant 0.15 isoniazid
dnaA 1064 p.Asp355Gly missense_variant 0.16 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.14 isoniazid
dnaA 1071 c.1071C>G synonymous_variant 0.14 isoniazid
dnaA 1088 p.Ser363Thr missense_variant 0.13 isoniazid Uncertain significance
gyrB 6109 c.870G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6123 p.Ala295Gly missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6127 c.888G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6142 c.903G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6148 c.909C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6170 p.His311Ala missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrA 6409 c.-893A>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrB 6416 p.Thr393Gly missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 6680 c.1441C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6703 c.-599G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6778 c.-524C>T upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.24 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.25 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7625 c.324G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7742 c.441G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7745 c.444G>A synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7758 c.457_459delATCinsGT frameshift_variant&missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7778 c.477G>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7853 c.552C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7892 c.591G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8253 p.Ile318Val missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8270 c.969G>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8357 c.1056G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8813 c.1512C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8817 p.Ser506Ala missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8849 c.1548C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8876 c.1575C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8951 c.1650G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8990 c.1689C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9281 c.1980C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>A synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9320 c.2019G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9362 c.2061C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9377 c.2076A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9413 c.2112G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9419 c.2118T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9420 p.Ile707Ala missense_variant 0.14 levofloxacin
moxifloxacin
fgd1 491223 c.441C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491226 c.444C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491248 p.Arg156Lys missense_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491280 c.498C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491284 p.Gly168Ser missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491292 c.510G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491310 c.528C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491316 c.534C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491328 c.546C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491640 c.858G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491652 c.870C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
ccsA 620029 c.139C>T synonymous_variant 1.0 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620349 c.459A>G synonymous_variant 0.13 capreomycin
amikacin
kanamycin
ccsA 620361 c.471C>T synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620366 p.Asn159Thr missense_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620379 c.489G>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620409 c.519C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.21 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620431 p.Leu181Ile missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620541 c.651G>C synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620547 c.657C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620559 c.669A>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620569 c.679_681delGGAinsCC frameshift_variant&missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620625 c.735A>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620634 c.744C>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620648 p.Glu253Gly missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620652 c.762C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
Rv0565c 656262 c.1209C>G synonymous_variant 0.14 ethionamide
Rv0565c 656265 c.1206G>C synonymous_variant 0.13 ethionamide
Rv0565c 656277 c.1194C>T synonymous_variant 0.13 ethionamide
Rv0565c 656283 c.1188G>T synonymous_variant 0.14 ethionamide
Rv0565c 656298 c.1173G>C synonymous_variant 0.15 ethionamide
Rv0565c 656307 c.1164G>C synonymous_variant 0.14 ethionamide
Rv0565c 656310 c.1161T>C synonymous_variant 0.14 ethionamide
Rv0565c 656325 c.1146C>G synonymous_variant 0.15 ethionamide
Rv0565c 656330 p.Val381Leu missense_variant 0.15 ethionamide
Rv0565c 657590 c.-120G>A upstream_gene_variant 1.0 ethionamide
hadA 731789 c.-141A>G upstream_gene_variant 0.21 isoniazid
hadA 731801 c.-129C>T upstream_gene_variant 0.2 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 0.17 isoniazid
hadA 731831 c.-99G>A upstream_gene_variant 0.15 isoniazid
nusG 734451 c.198G>C synonymous_variant 0.19 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.2 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.24 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734502 c.249G>A synonymous_variant 0.28 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.2 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.18 rifampicin
nusG 734814 c.561G>C synonymous_variant 0.22 rifampicin
nusG 734820 c.567A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.28 rifampicin
nusG 734841 c.588G>C synonymous_variant 0.27 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.26 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.26 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.25 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.28 rifampicin
nusG 734863 p.Thr204Ser missense_variant 0.3 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.33 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.31 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.25 rifampicin
nusG 734922 c.669C>G synonymous_variant 0.19 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.18 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>G synonymous_variant 0.2 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760139 c.333A>C synonymous_variant 0.21 rifampicin
rpoB 760142 c.336C>G synonymous_variant 0.19 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.19 rifampicin
rpoB 760155 p.Lys117Arg missense_variant 0.17 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.25 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>G synonymous_variant 0.24 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.2 rifampicin Uncertain significance
rpoB 760587 c.781_783delACCinsGG frameshift_variant&missense_variant 0.23 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.22 rifampicin
rpoB 760593 p.Gly263Asn missense_variant 0.22 rifampicin
rpoB 760596 p.Thr264Ser missense_variant 0.24 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.29 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760674 c.868T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>G synonymous_variant 0.19 rifampicin
rpoB 760919 c.1113C>T synonymous_variant 0.19 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.18 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.18 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.18 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.3 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.28 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761066 c.1260G>C synonymous_variant 0.26 rifampicin
rpoB 761075 c.1269G>A synonymous_variant 0.28 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.31 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.3 rifampicin
rpoB 761129 c.1323G>A synonymous_variant 0.25 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>G synonymous_variant 0.29 rifampicin
rpoB 761150 c.1344A>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>G synonymous_variant 0.16 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761201 c.1395G>A synonymous_variant 0.18 rifampicin
rpoB 761204 c.1398C>T synonymous_variant 0.21 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.22 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.2 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.2 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761252 c.1446C>G synonymous_variant 0.2 rifampicin
rpoB 761255 c.1449T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>A synonymous_variant 0.24 rifampicin
rpoB 761318 c.1512G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.24 rifampicin
rpoB 761333 c.1527G>C synonymous_variant 0.25 rifampicin
rpoB 761345 c.1539G>C synonymous_variant 0.27 rifampicin
rpoB 761346 p.Val514Asn missense_variant 0.26 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.25 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761369 p.Glu521Asp missense_variant 0.27 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.26 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.14 rifampicin
rpoB 761477 c.1671C>T synonymous_variant 0.14 rifampicin
rpoB 761482 p.Ala559Gly missense_variant 0.15 rifampicin
rpoB 761489 c.1683G>A synonymous_variant 0.16 rifampicin Not assoc w R
rpoB 761492 c.1686G>C synonymous_variant 0.16 rifampicin
rpoB 761502 c.1696_1698delCCCinsTG frameshift_variant&missense_variant 0.21 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.25 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.28 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.28 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.31 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.24 rifampicin
rpoB 761657 c.1851C>A synonymous_variant 0.23 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.21 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.2 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.19 rifampicin
rpoB 761760 p.Ile652Val missense_variant 0.17 rifampicin
rpoB 761765 c.1959T>G synonymous_variant 0.17 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.18 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.2 rifampicin
rpoB 761791 p.Arg662Gln missense_variant 0.19 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.24 rifampicin
rpoB 761814 p.Ala670Asn missense_variant 0.24 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.21 rifampicin
rpoB 761847 c.2041_2043delTGCinsCT frameshift_variant&missense_variant 0.15 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.14 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.15 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 0.15 rifampicin
rpoB 761873 c.2067A>T synonymous_variant 0.17 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.18 rifampicin
rpoB 761903 c.2097T>G synonymous_variant 0.23 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.21 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.2 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.2 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.2 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.22 rifampicin
rpoB 761930 c.2124G>T synonymous_variant 0.2 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.24 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.21 rifampicin
rpoB 762134 c.2328C>T synonymous_variant 0.2 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.21 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.21 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762212 c.2406G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.31 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.31 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.3 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.32 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.35 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762320 c.2514C>G synonymous_variant 0.33 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.31 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.33 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.36 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.36 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.36 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.34 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.3 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.3 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.28 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 762449 c.-921C>T upstream_gene_variant 0.25 rifampicin
rpoB 762452 c.2646G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.25 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.25 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.22 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.22 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.21 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.23 rifampicin
rpoC 762563 c.-807G>C upstream_gene_variant 0.19 rifampicin
rpoB 762814 p.Met1003Thr missense_variant 0.22 rifampicin Uncertain significance
rpoB 762818 c.3012C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.37 rifampicin
rpoC 763076 c.-294C>G upstream_gene_variant 0.34 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.31 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.33 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.32 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.29 rifampicin
rpoC 763187 c.-183C>G upstream_gene_variant 0.31 rifampicin
rpoB 763193 c.3387C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>G upstream_gene_variant 0.28 rifampicin
rpoB 763203 p.Ser1133Ala missense_variant 0.28 rifampicin Uncertain significance
rpoB 763207 p.Ser1134Lys missense_variant 0.29 rifampicin Uncertain significance
rpoB 763227 c.3421C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763262 c.-108C>A upstream_gene_variant 0.17 rifampicin
rpoC 763265 c.-105G>C upstream_gene_variant 0.17 rifampicin
rpoC 763396 c.27A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.26 rifampicin
rpoC 763430 c.61A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763447 c.78C>T synonymous_variant 0.28 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.33 rifampicin
rpoC 763468 c.99G>A synonymous_variant 0.32 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763495 c.126G>A synonymous_variant 0.31 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.3 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.21 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.21 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.18 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.16 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.25 rifampicin
rpoC 763927 c.558C>T synonymous_variant 0.27 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.25 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.16 rifampicin
rpoC 764143 c.774G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764161 c.792G>C synonymous_variant 0.28 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764191 c.822C>G synonymous_variant 0.24 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.21 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764207 p.Val280Ile missense_variant 0.2 rifampicin
rpoC 764213 p.Arg282Lys missense_variant 0.21 rifampicin Uncertain significance
rpoC 764254 c.885G>C synonymous_variant 0.31 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.31 rifampicin
rpoC 764263 c.894G>T synonymous_variant 0.32 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.31 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.41 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.4 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.39 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.17 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 764404 c.1035C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.23 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.2 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.23 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.23 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.25 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.3 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.31 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.33 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764656 c.1287C>G synonymous_variant 0.31 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764680 c.1311G>A synonymous_variant 0.3 rifampicin
rpoC 764746 c.1377G>A synonymous_variant 0.25 rifampicin
rpoC 764752 c.1383G>T synonymous_variant 0.27 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.28 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.3 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.24 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764896 c.1527C>T synonymous_variant 0.21 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.17 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.17 rifampicin Uncertain significance
rpoC 764932 c.1563C>G synonymous_variant 0.18 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.17 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765013 c.1644C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765016 c.1647C>T synonymous_variant 0.22 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.25 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765079 c.1710T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.2 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.21 rifampicin
rpoC 765115 c.1746G>T synonymous_variant 0.17 rifampicin
rpoC 765405 p.Leu679Pro missense_variant 0.13 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765412 c.2043T>C synonymous_variant 0.15 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765445 c.2076G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765453 p.Ala695Val missense_variant 0.34 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765526 c.2157C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765533 p.Tyr722His missense_variant 0.32 rifampicin Uncertain significance
rpoC 765547 c.2178C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.27 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.3 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.33 rifampicin
rpoC 765611 p.His748Ser missense_variant 0.28 rifampicin Uncertain significance
rpoC 765625 c.2256C>T synonymous_variant 0.31 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765635 c.2266_2268delGTCinsCG frameshift_variant&missense_variant 0.32 rifampicin
rpoC 765640 c.2271A>G synonymous_variant 0.3 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765661 c.2292T>C synonymous_variant 0.25 rifampicin
rpoC 765662 c.2293_2295delTTGinsCC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 765669 p.His767Arg missense_variant 0.26 rifampicin
rpoC 765673 p.Asp768Glu missense_variant 0.25 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765709 p.Glu780Asp missense_variant 0.24 rifampicin
rpoC 765718 p.Asp783Glu missense_variant 0.19 rifampicin Uncertain significance
rpoC 765721 c.2352G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765724 c.2355C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.19 rifampicin
rpoC 765742 p.Glu791Asp missense_variant 0.18 rifampicin Uncertain significance
rpoC 765751 c.2382C>G synonymous_variant 0.16 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.15 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.26 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.21 rifampicin
rpoC 765790 c.2421C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765793 c.2424C>G synonymous_variant 0.21 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.24 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765823 c.2454C>G synonymous_variant 0.26 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.32 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.32 rifampicin Uncertain significance
rpoC 765904 c.2535C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.3 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765991 c.2622C>G synonymous_variant 0.2 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766000 c.2631G>C synonymous_variant 0.17 rifampicin
rpoC 766003 c.2634G>C synonymous_variant 0.17 rifampicin
rpoC 766009 c.2640G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766294 c.2925C>T synonymous_variant 0.16 rifampicin
rpoC 766297 c.2928G>C synonymous_variant 0.16 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>C synonymous_variant 0.19 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.21 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766351 c.2982C>G synonymous_variant 0.24 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.22 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.23 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.22 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.23 rifampicin
rpoC 766393 c.3024C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766408 c.3039C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.2 rifampicin
rpoC 766435 p.Glu1022Asp missense_variant 0.23 rifampicin Uncertain significance
rpoC 766456 c.3087C>G synonymous_variant 0.26 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.24 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.23 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.23 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.24 rifampicin
rpoC 766517 p.Thr1050Ala missense_variant 0.28 rifampicin
rpoC 766522 c.3153C>A synonymous_variant 0.29 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.24 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.23 rifampicin
rpoC 766537 c.3168G>A synonymous_variant 0.25 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.27 rifampicin
rpoC 766547 p.Arg1060Lys missense_variant 0.3 rifampicin
rpoC 766564 c.3195C>G synonymous_variant 0.33 rifampicin
rpoC 766570 c.3201T>G synonymous_variant 0.29 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.3 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.21 rifampicin
rpoC 766610 p.Ser1081Pro missense_variant 0.21 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.26 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.26 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.28 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.27 rifampicin
rpoC 766654 c.3285C>G synonymous_variant 0.24 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.23 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.23 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.23 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.26 rifampicin
rpoC 766690 c.3321G>T synonymous_variant 0.25 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.24 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.21 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.18 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.22 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.26 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.29 rifampicin
rpoC 766775 p.Arg1136Asn missense_variant 0.28 rifampicin
rpoC 766787 p.Glu1140Gln missense_variant 0.34 rifampicin Uncertain significance
rpoC 766798 c.3429C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>G synonymous_variant 0.21 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767041 c.3672G>C synonymous_variant 0.23 rifampicin
rpoC 767044 c.3675G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.19 rifampicin
rpoC 767110 c.3741T>C synonymous_variant 0.19 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767182 c.3813G>C synonymous_variant 0.25 rifampicin
rpoC 767197 c.3828G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>T synonymous_variant 0.23 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>A synonymous_variant 0.15 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.14 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.14 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.15 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.14 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.22 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.22 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.24 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.25 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.27 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.28 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.26 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.26 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.25 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.29 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.29 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.29 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.33 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.34 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.35 streptomycin
rplC 800645 c.-164C>G upstream_gene_variant 0.25 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.27 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.28 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.4 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.39 linezolid
rplC 800744 c.-65G>C upstream_gene_variant 0.26 linezolid
rplC 800745 c.-64_-62delCTCinsTG upstream_gene_variant 0.25 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.22 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.2 linezolid
fbiC 1303575 c.645G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303587 c.657G>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303593 c.663G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304567 p.Phe546Tyr missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304608 p.Thr560Val missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
sigE 1364919 c.507T>C synonymous_variant 0.14 pyrazinamide
sigE 1364952 c.540A>G synonymous_variant 0.15 pyrazinamide
sigE 1364960 p.Gly183Asp missense_variant 0.16 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>G synonymous_variant 0.15 pyrazinamide
sigE 1364979 c.567C>G synonymous_variant 0.15 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.15 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.15 pyrazinamide
sigE 1364992 p.Pro194Ala missense_variant 0.15 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>G non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472292 n.447A>G non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453G>C non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472302 n.457_462delGGGTTCinsAGGGTTT non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472311 n.466delCinsTT non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472431 n.586G>A non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838_839insTA non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230delTinsAA non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473935 n.278C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1474045 n.388C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474100 n.443C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474106 n.449A>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474107 n.450T>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474108 n.451C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474109 n.452A>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474110 n.453A>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474350 n.693G>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474452 n.795C>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052dupG non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1474711 n.1054_1055insA non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474715 n.1061delA non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475221 n.1564C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475433 n.1776A>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476108 n.2451T>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476246 n.2589G>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476262 n.2605G>A non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.6 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
inhA 1673541 c.-661G>C upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1673547 c.-655T>C upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1673556 c.-646C>A upstream_gene_variant 0.15 ethionamide
isoniazid
inhA 1673568 c.-634C>G upstream_gene_variant 0.13 ethionamide
isoniazid
inhA 1674353 p.Thr51Ile missense_variant 0.14 ethionamide
isoniazid
inhA 1674368 p.Ala56Glu missense_variant 0.18 ethionamide
isoniazid
inhA 1674370 p.Lys57Pro missense_variant 0.19 ethionamide
isoniazid
inhA 1674375 c.174C>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674399 c.198A>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674403 c.202_204delGAGinsAC frameshift_variant&missense_variant 0.21 ethionamide
isoniazid
inhA 1674414 c.213G>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674416 p.Ala72Asp missense_variant 0.2 ethionamide
isoniazid
inhA 1674419 p.Ser73Thr missense_variant 0.19 ethionamide
isoniazid
inhA 1674421 c.220T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674428 p.Gly76Asp missense_variant 0.21 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674435 c.234G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674443 p.Ala81Val missense_variant 0.25 ethionamide
isoniazid
inhA 1674450 c.249G>T synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674452 p.Ala84Glu missense_variant 0.18 ethionamide
isoniazid
inhA 1674471 c.270G>T synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674483 c.282G>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674534 c.333G>C synonymous_variant 0.27 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674539 p.Tyr113Phe missense_variant 0.25 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.25 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.29 ethionamide
isoniazid
inhA 1674573 c.372G>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674579 c.378G>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.33 ethionamide
isoniazid
inhA 1674597 c.396G>A synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674600 c.399G>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674618 c.417C>T synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674628 p.Ser143Gly missense_variant 0.29 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.3 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674702 c.501G>A synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674729 c.528G>A synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674745 p.Tyr182Val missense_variant 0.27 ethionamide
isoniazid
inhA 1674756 c.555T>G synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674765 c.564C>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674777 c.576C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674810 c.609C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674819 c.618G>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674825 c.624C>T synonymous_variant 0.16 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674830 p.Glu210Gly missense_variant 0.15 ethionamide
isoniazid
inhA 1674839 p.Ala213Glu missense_variant 0.13 ethionamide
isoniazid
inhA 1674848 p.Gln216Arg missense_variant 0.15 ethionamide
isoniazid Uncertain significance
inhA 1674870 c.669T>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674876 c.675C>G synonymous_variant 0.15 ethionamide
isoniazid
rpsA 1833547 c.6G>A synonymous_variant 0.13 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.24 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.2 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.19 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.22 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.24 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.39 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.44 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.44 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.43 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.46 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.43 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.36 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833814 c.273C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833820 c.279G>A synonymous_variant 0.37 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.35 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.36 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.36 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.36 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.38 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.44 pyrazinamide
rpsA 1833958 c.417C>T synonymous_variant 0.39 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.42 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834042 c.501G>A synonymous_variant 0.43 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.42 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.31 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834432 c.891G>T synonymous_variant 0.27 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.29 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.36 pyrazinamide
rpsA 1834522 c.981C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834527 p.Arg329His missense_variant 0.32 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834573 c.1032G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.29 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.26 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.25 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834751 c.1210_1212delCTTinsAC frameshift_variant&missense_variant 0.18 pyrazinamide Uncertain significance
rpsA 1834756 c.1215G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834759 c.1218A>T synonymous_variant 0.2 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.25 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.25 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.27 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102653 p.His130Gln missense_variant 0.17 ethionamide
delamanid
isoniazid
PPE35 2170568 p.Ile15Met missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.32 isoniazid
kasA 2517926 c.-189G>A upstream_gene_variant 0.29 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.29 isoniazid
kasA 2517950 c.-165C>G upstream_gene_variant 0.3 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.15 isoniazid
kasA 2518555 c.441C>G synonymous_variant 0.17 isoniazid
kasA 2518561 c.447T>G synonymous_variant 0.17 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.16 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.14 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.14 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.16 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.17 isoniazid
kasA 2518663 c.549T>G synonymous_variant 0.18 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.23 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.22 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.22 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.19 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.19 isoniazid
kasA 2518726 c.612G>C synonymous_variant 0.21 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.21 isoniazid
kasA 2518738 c.624G>C synonymous_variant 0.21 isoniazid
kasA 2518739 p.Ala209Thr missense_variant 0.21 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.22 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.22 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.15 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.14 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.13 isoniazid
folC 2747002 c.597T>C synonymous_variant 0.15 para-aminosalicylic_acid
folC 2747014 c.585C>T synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747023 c.576C>G synonymous_variant 0.15 para-aminosalicylic_acid
folC 2747036 p.Asn188Thr missense_variant 0.13 para-aminosalicylic_acid
Rv2477c 2782465 c.1578G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782501 c.1542T>C synonymous_variant 0.29 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782522 c.1521G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783107 c.936G>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783156 p.Ala296Val missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 p.Ala295Val missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Uncertain significance
amikacin
Rv2477c 2783173 c.870C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783192 p.Ser284Asn missense_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783456 p.Gln196Leu missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 c.544_546delTTGinsCC frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783502 c.541T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783634 p.Leu137Ile missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783651 p.His131Ala missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783668 c.375G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783672 p.Arg124Lys missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065675 p.Phe173Leu missense_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066071 c.121T>C synonymous_variant 0.14 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066081 c.111G>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066096 c.96G>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067373 c.573C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067388 c.558C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067427 c.519G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067430 c.516C>T synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067847 c.99C>G synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.15 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067886 c.60A>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067889 c.57C>A synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067892 c.52_54delTTGinsAC frameshift_variant&missense_variant 0.14 para-aminosalicylic_acid
thyX 3067910 c.36C>T synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073845 c.627C>T synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073881 c.591C>A synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3073887 p.Ser195Gly missense_variant 0.29 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073905 c.567C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073962 c.510G>T synonymous_variant 0.16 para-aminosalicylic_acid
fbiD 3339002 c.-116A>G upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
Rv3083 3448472 c.-32A>G upstream_gene_variant 1.0 ethionamide
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625243 c.-333T>G upstream_gene_variant 0.15 bedaquiline
rifampicin
lpqB 3625252 c.-342G>T upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625255 c.-345T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625258 c.-348G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625263 p.Tyr451His missense_variant 0.16 bedaquiline
rifampicin
lpqB 3625273 c.-363C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625276 c.-366C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625282 c.-372C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625313 p.Arg434Val missense_variant 0.23 bedaquiline
rifampicin
mtrB 3625321 c.1293A>G synonymous_variant 0.21 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>T upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625678 c.-768C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625683 c.-773C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625687 c.-777G>T upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625720 c.-810G>A upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625723 c.-813C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.36 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>T synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625768 c.-858G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3625774 c.840G>A synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625806 c.808A>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625819 c.795G>A synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625822 c.-912C>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625837 c.777C>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626972 c.-359A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626996 c.-383G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3627068 c.282T>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627119 c.231T>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627128 c.-515T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3627131 p.Ala73Lys missense_variant 0.15 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3627146 c.204C>T synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627149 c.-536G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627152 c.-539C>T upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
fbiA 3640708 p.Leu56Val missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiB 3640713 c.-822T>C upstream_gene_variant 0.16 clofazimine
pretomanid
delamanid
fbiA 3640714 p.Val58Ile missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiB 3640722 c.-813G>C upstream_gene_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3640743 c.-792T>C upstream_gene_variant 0.16 clofazimine
pretomanid
delamanid
fbiB 3640758 c.-777G>C upstream_gene_variant 0.16 clofazimine
pretomanid
delamanid
rpoA 3877533 c.975C>T synonymous_variant 0.23 rifampicin
rpoA 3877548 c.960C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877553 p.Glu319Gln missense_variant 0.31 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 0.3 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.36 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.34 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.3 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.32 rifampicin
rpoA 3877677 c.831G>T synonymous_variant 0.3 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877689 c.819C>G synonymous_variant 0.29 rifampicin
rpoA 3877692 c.816G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.28 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877788 c.720G>A synonymous_variant 0.25 rifampicin
rpoA 3877827 c.681C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>T synonymous_variant 0.15 rifampicin
rpoA 3877842 c.666A>G synonymous_variant 0.16 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877860 c.648C>G synonymous_variant 0.15 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.15 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.21 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.25 rifampicin
rpoA 3877905 c.603A>C synonymous_variant 0.27 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.31 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.21 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.21 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878166 c.342C>G synonymous_variant 0.31 rifampicin
rpoA 3878175 c.333G>T synonymous_variant 0.34 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Val missense_variant 0.33 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878244 c.264G>A synonymous_variant 0.29 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.24 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.22 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.24 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.24 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.25 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.25 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.3 rifampicin
rpoA 3878358 c.150C>G synonymous_variant 0.27 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.29 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.3 rifampicin
rpoA 3878394 c.114G>T synonymous_variant 0.3 rifampicin
rpoA 3878400 c.108T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.19 rifampicin
rpoA 3878575 c.-68C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoA 3878873 c.-366G>A upstream_gene_variant 0.17 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878887 c.-382_-380delAACinsGT upstream_gene_variant 0.2 rifampicin
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.2 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.25 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.23 rifampicin
rpoA 3878947 c.-440G>T upstream_gene_variant 0.19 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.16 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.15 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879079 c.-572A>C upstream_gene_variant 0.15 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.17 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.17 rifampicin
rpoA 3879097 c.-590C>T upstream_gene_variant 0.19 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.23 rifampicin
rpoA 3879124 c.-618_-617delTGinsGA upstream_gene_variant 0.22 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.22 rifampicin
rpoA 3879144 c.-637A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879148 c.-641G>C upstream_gene_variant 0.19 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.16 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.14 rifampicin
ddn 3986633 c.-211C>G upstream_gene_variant 0.32 delamanid
pretomanid
ddn 3986636 c.-208C>T upstream_gene_variant 0.3 delamanid
pretomanid
ddn 3986645 c.-199G>A upstream_gene_variant 0.25 delamanid
pretomanid
ddn 3986661 c.-183_-179delCAGAGinsT upstream_gene_variant 0.16 delamanid
pretomanid
clpC1 4038318 p.Pro796Leu missense_variant 0.96 pyrazinamide Not assoc w R
clpC1 4038563 c.2142C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038569 c.2136C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038575 c.2130C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038620 p.Gln695Leu missense_variant 0.22 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.24 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.23 pyrazinamide
clpC1 4038650 c.2055C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.2 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.18 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038671 c.2034T>A synonymous_variant 0.21 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.2 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038704 c.2001T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038726 p.Thr660Cys missense_variant 0.22 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.27 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.29 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038809 p.Gln632Ser missense_variant 0.24 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.27 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.27 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 0.15 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039091 c.1614G>A synonymous_variant 0.16 pyrazinamide
clpC1 4039094 c.1611C>A synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039097 c.1608G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.16 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039223 c.1482C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039439 c.1266C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039451 c.1254G>A synonymous_variant 0.16 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039472 c.1233G>T synonymous_variant 0.21 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.29 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Ser missense_variant 0.29 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039581 p.Thr375Ser missense_variant 0.29 pyrazinamide
clpC1 4039589 c.1116G>T synonymous_variant 0.31 pyrazinamide
clpC1 4039601 c.1104G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039604 c.1101G>A synonymous_variant 0.3 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039655 c.1050G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.33 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039733 c.972G>T synonymous_variant 0.27 pyrazinamide
clpC1 4039736 c.969C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039925 c.780C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039957 c.748C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.35 pyrazinamide
clpC1 4040001 p.His235Ala missense_variant 0.31 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040033 c.672G>T synonymous_variant 0.27 pyrazinamide
clpC1 4040036 c.669C>A synonymous_variant 0.28 pyrazinamide
clpC1 4040057 c.648C>T synonymous_variant 0.24 pyrazinamide
clpC1 4040063 c.642G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040095 p.Leu204Phe missense_variant 0.14 pyrazinamide
clpC1 4040135 c.570C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040168 c.537G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040180 c.525C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040213 c.492T>A synonymous_variant 0.23 pyrazinamide
clpC1 4040225 c.480A>T synonymous_variant 0.18 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040234 c.471C>A synonymous_variant 0.24 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.26 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.23 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.27 pyrazinamide
clpC1 4040441 c.264C>T synonymous_variant 0.27 pyrazinamide
clpC1 4040444 c.261C>A synonymous_variant 0.27 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.21 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040539 c.166C>T synonymous_variant 0.19 pyrazinamide
clpC1 4040540 c.165G>T synonymous_variant 0.21 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040618 c.87C>G synonymous_variant 0.14 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.14 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.13 pyrazinamide
glpK 4138565 c.1191G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138598 c.1158G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138654 c.1102C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138655 c.1101G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138661 c.1095T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139585 c.171G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139621 c.135G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid
glpK 4139630 c.126C>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139636 p.Ala40Gly missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139645 c.111C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139651 c.103_105delCACinsGT frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139666 p.Met30Ile missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240726 c.864G>C synonymous_variant 0.13 ethambutol Not assoc w R - Interim
embC 4240736 c.874_875delTCinsAG synonymous_variant 0.16 ethambutol
embC 4240765 c.903C>G synonymous_variant 0.24 ethambutol
embC 4240768 c.906G>C synonymous_variant 0.24 ethambutol
embC 4240769 c.907_909delGTGinsAC frameshift_variant&missense_variant 0.24 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.28 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.28 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.28 ethambutol
embC 4240800 p.Tyr313Phe missense_variant 0.25 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.16 ethambutol
embC 4240822 c.960C>G synonymous_variant 0.15 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.14 ethambutol
embC 4241024 p.Val388Phe missense_variant 0.14 ethambutol
embC 4241039 p.Asp393Asn missense_variant 0.2 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.18 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.18 ethambutol
embC 4241053 c.1191G>T synonymous_variant 0.19 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.23 ethambutol
embC 4241084 p.Leu408Ala missense_variant 0.23 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.22 ethambutol
embC 4241122 c.1260C>T synonymous_variant 0.24 ethambutol
embC 4241135 p.Val425Leu missense_variant 0.21 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Phe missense_variant 0.2 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.23 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241162 p.Leu434Met missense_variant 0.19 ethambutol
embC 4241167 c.1305C>G synonymous_variant 0.19 ethambutol
embC 4241168 c.1306C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241179 c.1317G>T synonymous_variant 0.2 ethambutol
embC 4241185 c.1323G>C synonymous_variant 0.18 ethambutol
embC 4241188 c.1326C>G synonymous_variant 0.19 ethambutol
embC 4241194 c.1332C>G synonymous_variant 0.2 ethambutol
embC 4241215 c.1353C>G synonymous_variant 0.17 ethambutol
embC 4241218 c.1356G>C synonymous_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243069 c.-164C>T upstream_gene_variant 1.0 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.19 ethambutol
embB 4247462 c.949_950delTCinsAG synonymous_variant 0.22 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.2 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.17 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.16 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.16 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248173 p.Val554Met missense_variant 0.16 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin