TB-Profiler result

Run: SRR12142339
Summary

Run ID: SRR12142339

Sample name:

Date: 2024-03-26T19:14:22.642047

Number of reads: 7217622

Percentage reads mapped: 66.03

Median coverage: 160.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.98
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
La1.7.1 M.bovis None 0.08
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser315Asn Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
gyrA p.Ser91Pro Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ofloxacin
levofloxacin gyrB p.Thr500Asn Uncertain significance Mutation from literature
gyrA p.Ser91Pro Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.2265_2266delTG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2275_2280delCCCGGGinsGGCCCGGC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrB 6738 p.Thr500Asn missense_variant 0.18 moxifloxacin Uncertain significance Mutation from literature
levofloxacin Uncertain significance Mutation from literature
gyrA 7572 p.Ser91Pro missense_variant 0.72 moxifloxacin Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
levofloxacin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.8 streptomycin Assoc w R
fbiC 1305193 c.2265_2266delTG frameshift_variant 0.23 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305205 c.2275_2280delCCCGGGinsGGCCCGGC frameshift_variant&missense_variant 0.21 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155168 p.Ser315Asn missense_variant 1.0 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6700 c.-602T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6763 c.1524G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6775 c.-527G>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.16 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7418 c.117C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7442 c.141G>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7466 c.165G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7490 c.189C>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7514 c.213C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7538 c.237G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7607 c.306C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7671 p.Pro124Ala missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCT frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7727 c.426G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7745 c.444G>A synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7758 c.457_459delATCinsGT frameshift_variant&missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8846 c.1545C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8867 c.1566A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8948 p.Leu549Phe missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491284 p.Gly168Trp missense_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575705 c.358T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575714 p.Tyr123Asn missense_variant 0.17 ethionamide
isoniazid
mshA 575728 c.381C>T synonymous_variant 0.22 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.25 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.32 ethionamide
isoniazid
mshA 575772 p.Val142Ala missense_variant 0.32 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.31 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.31 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.31 ethionamide
isoniazid Not assoc w R - Interim
mshA 575837 c.490C>T synonymous_variant 0.27 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575841 c.494_495insT frameshift_variant 0.27 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575844 c.498delC frameshift_variant 0.26 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575848 c.501C>T synonymous_variant 0.26 ethionamide
isoniazid
mshA 575851 c.504C>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575892 p.Ala182Gly missense_variant 0.19 ethionamide
isoniazid
mshA 575905 c.558G>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575907 p.Ala187Val missense_variant 0.83 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575916 p.Asp190Ala missense_variant 0.15 ethionamide
isoniazid
mshA 575920 c.573C>G synonymous_variant 0.15 ethionamide
isoniazid
ccsA 620349 c.459A>C synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 0.98 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.17 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.22 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.22 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.25 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.25 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.26 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.26 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.27 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734505 c.252G>T synonymous_variant 0.28 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.15 rifampicin
rpoB 760070 c.264T>C synonymous_variant 0.15 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760118 c.312T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>G synonymous_variant 0.22 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760139 c.333A>T synonymous_variant 0.24 rifampicin
rpoB 760142 c.336C>G synonymous_variant 0.23 rifampicin
rpoB 760148 p.Asp114Glu missense_variant 0.23 rifampicin
rpoB 760155 p.Lys117Arg missense_variant 0.22 rifampicin
rpoB 760172 c.366G>C synonymous_variant 0.29 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>G synonymous_variant 0.37 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.41 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>G synonymous_variant 0.37 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 0.32 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.29 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760354 p.Glu183Ala missense_variant 0.19 rifampicin
rpoB 760357 p.Thr184Asn missense_variant 0.19 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760541 c.735G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.17 rifampicin Uncertain significance
rpoB 760585 p.Asn260Ser missense_variant 0.17 rifampicin
rpoB 760587 p.Thr261Ala missense_variant 0.17 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.16 rifampicin
rpoB 760593 p.Gly263Ser missense_variant 0.16 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.16 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.24 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.3 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.32 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.33 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.33 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.34 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.35 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761201 c.1395G>A synonymous_variant 0.32 rifampicin
rpoB 761204 c.1398C>T synonymous_variant 0.31 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.33 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.34 rifampicin
rpoB 761240 c.1434C>T synonymous_variant 0.3 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.29 rifampicin
rpoB 761286 c.1480C>T synonymous_variant 0.26 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.15 rifampicin
rpoB 761346 p.Val514Ile missense_variant 0.15 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.15 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761366 c.1560C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761374 p.Val523Glu missense_variant 0.15 rifampicin
rpoB 761502 p.Pro566Ser missense_variant 0.14 rifampicin
rpoB 761508 c.1702_1704delTCTinsGC frameshift_variant&missense_variant 0.16 rifampicin
rpoB 761516 c.1710G>C synonymous_variant 0.18 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.31 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.37 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761627 c.1821C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.3 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.33 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.31 rifampicin
rpoB 761687 c.1881C>G synonymous_variant 0.29 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.26 rifampicin
rpoB 761702 c.1896C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761711 c.1905C>G synonymous_variant 0.2 rifampicin
rpoB 761712 p.Val636Ile missense_variant 0.19 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 0.18 rifampicin Not assoc w R
rpoB 761724 c.1918_1920delGAAinsAG frameshift_variant&missense_variant 0.18 rifampicin
rpoB 761728 p.Ser641Thr missense_variant 0.18 rifampicin
rpoB 761732 c.1926C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761750 c.1944G>C synonymous_variant 0.18 rifampicin
rpoB 761760 p.Ile652Val missense_variant 0.18 rifampicin
rpoB 761765 c.1959T>G synonymous_variant 0.18 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.17 rifampicin
rpoB 761777 c.1971C>T synonymous_variant 0.16 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.16 rifampicin
rpoB 761791 p.Arg662Gln missense_variant 0.18 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.18 rifampicin
rpoB 761847 c.2041_2043delTGCinsCT frameshift_variant&missense_variant 0.15 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.16 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.16 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 0.16 rifampicin
rpoB 761873 c.2067A>T synonymous_variant 0.17 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.18 rifampicin
rpoB 761897 c.2091C>G synonymous_variant 0.16 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.16 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.16 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.16 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.16 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.18 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.23 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762006 c.2200_2202delCGCinsAG frameshift_variant&missense_variant 0.27 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762024 p.Val740Thr missense_variant 0.27 rifampicin Uncertain significance
rpoB 762029 c.2223C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762098 c.2292C>T synonymous_variant 0.24 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.32 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.35 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.34 rifampicin
rpoB 762134 c.2328C>T synonymous_variant 0.34 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.37 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.37 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762212 c.2406G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.44 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.45 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.41 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.41 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.35 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.41 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.4 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.41 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.39 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.4 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.4 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.36 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.35 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 762407 c.-963G>C upstream_gene_variant 0.34 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762449 c.2643C>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762490 p.Val895Ala missense_variant 0.29 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.25 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.24 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.23 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.22 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.21 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.21 rifampicin
rpoC 762557 c.-813G>C upstream_gene_variant 0.19 rifampicin
rpoC 762560 c.-810A>T upstream_gene_variant 0.18 rifampicin
rpoC 762563 c.-807G>T upstream_gene_variant 0.18 rifampicin
rpoB 762894 c.3088C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762957 c.3151C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.71 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.29 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.29 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.28 rifampicin
rpoB 763085 c.3279C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.29 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.29 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 0.3 rifampicin
rpoC 763193 c.-177C>T upstream_gene_variant 0.28 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.26 rifampicin
rpoB 763203 p.Ser1133Ala missense_variant 0.26 rifampicin Uncertain significance
rpoB 763207 p.Ser1134Lys missense_variant 0.26 rifampicin Uncertain significance
rpoB 763227 c.3421C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763262 c.-108C>A upstream_gene_variant 0.19 rifampicin
rpoC 763265 c.-105G>C upstream_gene_variant 0.17 rifampicin
rpoB 763283 c.3477T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763396 c.27A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763430 c.61A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763447 c.78C>T synonymous_variant 0.33 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.37 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.31 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.26 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.26 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.25 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.23 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.24 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764059 c.690G>T synonymous_variant 0.14 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764169 p.Asn267Thr missense_variant 0.24 rifampicin
rpoC 764180 p.Asp271His missense_variant 0.23 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Leu missense_variant 0.2 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.19 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764207 p.Val280Ile missense_variant 0.18 rifampicin
rpoC 764213 p.Arg282Lys missense_variant 0.19 rifampicin Uncertain significance
rpoC 764242 c.873C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>T synonymous_variant 0.26 rifampicin
rpoC 764254 c.885G>C synonymous_variant 0.28 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.28 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.26 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.26 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.26 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.26 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.23 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.23 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.28 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.3 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.31 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.29 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.31 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.31 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.32 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.34 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.3 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>A synonymous_variant 0.32 rifampicin
rpoC 764752 c.1383G>T synonymous_variant 0.35 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.35 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.31 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.34 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.36 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.36 rifampicin Uncertain significance
rpoC 764948 c.1579T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.27 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.23 rifampicin
rpoC 765076 c.1707A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765079 c.1710T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.2 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765115 c.1746G>T synonymous_variant 0.15 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.15 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765533 c.2164_2166delTACinsCT frameshift_variant&missense_variant 0.25 rifampicin
rpoC 765547 c.2178C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.26 rifampicin
rpoC 765553 c.2184C>A synonymous_variant 0.28 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.28 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.31 rifampicin
rpoC 765611 p.His748Ser missense_variant 0.34 rifampicin Uncertain significance
rpoC 765625 c.2256C>T synonymous_variant 0.35 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765635 c.2266_2268delGTCinsCG frameshift_variant&missense_variant 0.36 rifampicin
rpoC 765640 c.2271A>G synonymous_variant 0.35 rifampicin
rpoC 765655 c.2286T>G synonymous_variant 0.32 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765662 c.2293_2295delTTGinsCC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 765669 p.His767Arg missense_variant 0.32 rifampicin
rpoC 765673 p.Asp768Glu missense_variant 0.32 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765718 p.Asp783Glu missense_variant 0.3 rifampicin Uncertain significance
rpoC 765721 c.2352G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765724 c.2355C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.26 rifampicin
rpoC 765742 p.Glu791Asp missense_variant 0.27 rifampicin Uncertain significance
rpoC 765751 c.2382C>G synonymous_variant 0.28 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.27 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.29 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.28 rifampicin
rpoC 765790 c.2421C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765793 c.2424C>G synonymous_variant 0.28 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.28 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765823 c.2454C>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.3 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.29 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.32 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.3 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765991 c.2622C>G synonymous_variant 0.15 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766000 c.2631G>T synonymous_variant 0.14 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>A synonymous_variant 0.16 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.16 rifampicin
rpoC 766351 c.2982C>G synonymous_variant 0.24 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.32 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.35 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.35 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.35 rifampicin
rpoC 766393 c.3024C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766408 c.3039C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.35 rifampicin
rpoC 766435 p.Glu1022Asp missense_variant 0.35 rifampicin Uncertain significance
rpoC 766456 c.3087C>G synonymous_variant 0.35 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.36 rifampicin
rpoC 766484 c.3115_3117delGTAinsAT frameshift_variant&missense_variant 0.32 rifampicin
rpoC 766517 p.Thr1050Ala missense_variant 0.3 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.29 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.27 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.27 rifampicin
rpoC 766534 c.3165C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766537 c.3168G>A synonymous_variant 0.27 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.26 rifampicin
rpoC 766547 p.Arg1060Lys missense_variant 0.28 rifampicin
rpoC 766564 c.3195C>G synonymous_variant 0.29 rifampicin
rpoC 766570 c.3201T>G synonymous_variant 0.29 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766576 c.3207C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.28 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.24 rifampicin
rpoC 766610 p.Ser1081Pro missense_variant 0.24 rifampicin
rpoC 766618 c.3249G>T synonymous_variant 0.25 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.27 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.2 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.18 rifampicin
rpoC 766654 c.3285C>G synonymous_variant 0.18 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.17 rifampicin
rpoC 766661 p.Val1098Leu missense_variant 0.17 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.18 rifampicin
rpoC 766669 c.3300C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766672 c.3303T>C synonymous_variant 0.19 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.23 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.25 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.25 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.25 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.26 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.27 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.29 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.29 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.25 rifampicin
rpoC 766775 p.Arg1136Asn missense_variant 0.25 rifampicin
rpoC 766787 p.Glu1140Gln missense_variant 0.27 rifampicin Uncertain significance
rpoC 766798 c.3429C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766883 c.3514_3516delTCGinsGC frameshift_variant&missense_variant 0.23 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.23 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.23 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.23 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.23 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.22 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.22 rifampicin
rpoC 766918 c.3549C>G synonymous_variant 0.22 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.22 rifampicin
rpoC 766931 c.3562_3564delGCAinsAC frameshift_variant&missense_variant 0.23 rifampicin
rpoC 766935 p.Glu1189Ala missense_variant 0.22 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766960 c.3591C>T synonymous_variant 0.22 rifampicin
rpoC 766961 p.Gly1198Leu missense_variant 0.22 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.22 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767041 c.3672G>C synonymous_variant 0.28 rifampicin
rpoC 767044 c.3675G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.31 rifampicin
rpoC 767110 c.3741T>C synonymous_variant 0.32 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767152 c.3783T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767182 c.3813G>C synonymous_variant 0.3 rifampicin
rpoC 767197 c.3828G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>T synonymous_variant 0.21 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 778982 c.-77A>G upstream_gene_variant 0.97 clofazimine
bedaquiline Uncertain significance
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 0.99 streptomycin Not assoc w R
rpsL 781652 c.93T>G synonymous_variant 0.15 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.14 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.15 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin
rpsL 781685 c.126G>C synonymous_variant 0.18 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.25 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>G synonymous_variant 0.26 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.25 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.24 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.24 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.24 streptomycin
rpsL 781742 c.183C>G synonymous_variant 0.24 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.23 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.23 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.23 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.24 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.24 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.25 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.26 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.26 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.26 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.25 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.26 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.26 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.23 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.23 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.24 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.24 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.25 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.25 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.25 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.26 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.26 streptomycin Uncertain significance
rplC 800621 c.-188G>A upstream_gene_variant 0.16 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.2 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.2 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303512 c.582T>A synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303587 c.657G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303611 c.681G>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>C synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305132 c.2202C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305135 c.2205C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305150 c.2220C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305168 c.2238C>T synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305173 p.Asn748Ser missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305177 c.2247A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305181 c.2251T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305213 c.2283C>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305234 c.2304G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305237 c.2307A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305240 c.2310T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305243 c.2313T>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305259 c.2329T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305267 c.2337C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305274 p.Ser782Pro missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1305277 p.His783Asn missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
sigE 1364787 p.Gln125His missense_variant 0.15 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.17 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.2 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.18 pyrazinamide
sigE 1364818 c.406_408delCTAinsTG frameshift_variant&stop_gained 0.22 pyrazinamide Uncertain significance
sigE 1364838 c.426C>T synonymous_variant 0.24 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.25 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.24 pyrazinamide
sigE 1364860 p.Arg150Lys missense_variant 0.24 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.23 pyrazinamide
sigE 1364872 p.Ile154Val missense_variant 0.28 pyrazinamide
sigE 1364877 c.465G>T synonymous_variant 0.28 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.28 pyrazinamide Uncertain significance
sigE 1364892 c.480C>G synonymous_variant 0.28 pyrazinamide
sigE 1364913 c.501C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
sigE 1364919 c.507T>C synonymous_variant 0.27 pyrazinamide
sigE 1364926 p.Asn172Asp missense_variant 0.29 pyrazinamide
sigE 1364952 c.540A>G synonymous_variant 0.24 pyrazinamide
sigE 1364960 p.Gly183Asp missense_variant 0.19 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>G synonymous_variant 0.17 pyrazinamide
sigE 1364979 c.567C>G synonymous_variant 0.17 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.17 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.16 pyrazinamide
sigE 1364989 c.577C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
sigE 1364992 p.Pro194Ala missense_variant 0.17 pyrazinamide
sigE 1365003 c.591T>C synonymous_variant 0.16 pyrazinamide
sigE 1365006 c.594T>G synonymous_variant 0.16 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472292 n.447A>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453G>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472431 n.586G>A non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838_839insTA non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473111 n.1266A>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1473752 n.95G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1473812 n.155G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473828 n.171_175delGGTGCinsCCGGTG non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230delTinsAA non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474094 n.437C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474100 n.443C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474106 n.449A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474107 n.450T>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474108 n.451C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474109 n.452A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474110 n.453A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1052dupG non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474711 n.1054_1055insA non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474715 n.1061delA non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476108 n.2451T>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476246 n.2589G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476262 n.2605G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.49 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
inhA 1674471 c.270G>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674534 c.333G>C synonymous_variant 0.22 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674542 p.Ala114Glu missense_variant 0.2 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.2 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674579 c.378G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.23 ethionamide
isoniazid
inhA 1674597 c.396G>A synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674601 p.Leu134Val missense_variant 0.27 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674628 p.Ser143Gly missense_variant 0.24 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.25 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674699 c.498C>T synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674702 c.501G>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674745 p.Tyr182Val missense_variant 0.37 ethionamide
isoniazid
inhA 1674756 c.555T>G synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674765 c.564C>G synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674804 c.603G>C synonymous_variant 0.38 ethionamide Not assoc w R - Interim
isoniazid
inhA 1674810 c.609C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674819 c.618G>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674830 p.Glu210Gly missense_variant 0.34 ethionamide
isoniazid
inhA 1674839 p.Ala213Glu missense_variant 0.35 ethionamide
isoniazid
inhA 1674848 p.Gln216Arg missense_variant 0.35 ethionamide
isoniazid Uncertain significance
inhA 1674855 c.654C>G synonymous_variant 0.35 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674876 c.675C>G synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674888 c.687C>T synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674892 p.Asn231Asp missense_variant 0.25 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674903 c.702T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.22 ethionamide
isoniazid
inhA 1674915 c.714C>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674924 c.723G>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674927 c.726G>C synonymous_variant 0.16 ethionamide
isoniazid
rpsA 1833589 c.48A>C synonymous_variant 0.19 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.2 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.2 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.23 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.24 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.26 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.28 pyrazinamide
rpsA 1833770 p.Asn77His missense_variant 0.3 pyrazinamide
rpsA 1833778 c.237C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.28 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.32 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.36 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833814 c.273C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833820 c.279G>A synonymous_variant 0.34 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.34 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.33 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.36 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.35 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.36 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.31 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.32 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.31 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.29 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.32 pyrazinamide
rpsA 1834015 c.474G>T synonymous_variant 0.33 pyrazinamide
rpsA 1834018 c.477C>T synonymous_variant 0.33 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.28 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.3 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.29 pyrazinamide Uncertain significance
rpsA 1834172 p.Ile211Val missense_variant 0.3 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.99 pyrazinamide Not assoc w R - Interim
rpsA 1834213 c.672G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.39 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.4 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.36 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.38 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834474 c.933C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834522 c.981C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834527 p.Arg329His missense_variant 0.41 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834573 c.1032G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.42 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.36 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.39 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834751 c.1210_1212delCTTinsAC frameshift_variant&missense_variant 0.22 pyrazinamide Uncertain significance
rpsA 1834756 c.1215G>A synonymous_variant 0.22 pyrazinamide
rpsA 1834759 c.1218A>T synonymous_variant 0.21 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.21 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.21 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834792 c.1251G>T synonymous_variant 0.19 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.24 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.24 linezolid
tsnR 1853375 c.-231G>C upstream_gene_variant 0.23 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.26 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.26 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.26 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.24 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.23 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.22 linezolid
tsnR 1853441 c.-165C>T upstream_gene_variant 0.2 linezolid
tsnR 1853444 c.-162C>T upstream_gene_variant 0.19 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.17 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.16 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2103171 c.-129G>A upstream_gene_variant 0.99 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2222121 c.1044G>T synonymous_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.24 isoniazid
kasA 2517926 c.-189G>A upstream_gene_variant 0.24 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.21 isoniazid
kasA 2517965 c.-150C>T upstream_gene_variant 0.15 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.18 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.19 isoniazid
kasA 2518532 c.418C>T synonymous_variant 0.2 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.25 isoniazid
kasA 2518564 c.450C>G synonymous_variant 0.26 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.24 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.25 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.25 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.29 isoniazid
kasA 2518591 c.477G>T synonymous_variant 0.3 isoniazid
kasA 2518594 c.480C>T synonymous_variant 0.29 isoniazid
kasA 2518597 c.483C>T synonymous_variant 0.29 isoniazid
kasA 2518603 c.489G>A synonymous_variant 0.29 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.28 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.29 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.29 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.31 isoniazid
kasA 2518651 c.537C>G synonymous_variant 0.28 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.26 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.26 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.26 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.27 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.28 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.26 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.24 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.24 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.26 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.28 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.29 isoniazid
kasA 2518759 c.645C>G synonymous_variant 0.3 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.3 isoniazid
kasA 2518787 p.Arg225Lys missense_variant 0.28 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.28 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.29 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.31 isoniazid
kasA 2518822 c.708C>A synonymous_variant 0.29 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.28 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.24 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.22 isoniazid
kasA 2518867 c.753G>A synonymous_variant 0.22 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.19 isoniazid
kasA 2518882 c.768C>T synonymous_variant 0.18 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.17 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.15 isoniazid
folC 2747379 p.Gly74Ser missense_variant 1.0 para-aminosalicylic_acid
Rv2477c 2783386 c.657G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.618C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783432 c.610_611delAGinsTC synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783456 p.Gln196Leu missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 c.544_546delTTGinsCC frameshift_variant&missense_variant 0.34 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783502 c.541T>C synonymous_variant 0.34 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783516 c.526_527delTCinsAG synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783545 c.498C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783568 p.Asn159His missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783575 c.468G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783827 c.216C>T synonymous_variant 0.99 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783957 p.Tyr29Phe missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783989 c.54G>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784001 c.42G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784004 c.39G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784010 c.33C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065943 c.249C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065946 p.Gly82Ala missense_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065957 c.235T>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065972 p.Ile74Val missense_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065979 c.213T>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065982 c.210G>A synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065988 c.202_204delGAAinsCG frameshift_variant&missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065993 p.Val67Ile missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065997 c.195C>G synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066000 p.Met64Ile missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066018 c.174T>C synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066042 c.150T>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 c.142T>C synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyA 3073920 c.552C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073968 c.504C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 0.99 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625075 c.-165G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3625095 p.Glu507Lys missense_variant 0.19 bedaquiline
rifampicin
lpqB 3625099 c.-189C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625102 c.-192A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625111 c.-201G>T upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625117 c.-207T>G upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 0.18 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625141 c.-231T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625147 c.-237C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.19 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625612 c.-702G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3625623 p.Thr331Ser missense_variant 0.18 bedaquiline
rifampicin
mtrB 3625627 p.Asp329Glu missense_variant 0.18 bedaquiline
rifampicin
mtrB 3625636 p.Ala326Glu missense_variant 0.19 bedaquiline
rifampicin
mtrB 3625648 c.964_966delTATinsCC frameshift_variant&missense_variant 0.19 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625651 c.-741C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.2 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625675 c.-765G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625683 c.-773C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625747 c.867G>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.3 bedaquiline
rifampicin Uncertain significance
mtrB 3625761 p.Gln285Glu missense_variant 0.27 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>T synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625768 c.-858G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625801 c.-891G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625804 c.808_810delAGGinsCC frameshift_variant&missense_variant 0.26 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625807 c.807C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625816 c.-906C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625822 c.-912C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625837 c.777C>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625852 c.762A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626726 c.-113T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3626729 c.619_621delAAGinsCA frameshift_variant&missense_variant 0.16 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3626749 c.601C>T synonymous_variant 0.17 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626750 c.-137T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCA frameshift_variant&missense_variant 0.24 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626789 c.561C>T synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626792 c.-179G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626798 c.-185T>A upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626804 c.-191A>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626816 c.-203G>T upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3626822 p.Asp176Glu missense_variant 0.19 bedaquiline
rifampicin
mtrB 3626840 c.-227C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626885 c.-272A>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626969 c.-356C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626996 c.-383G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3627068 c.282T>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627083 c.-470G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627119 c.231T>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627128 c.-515T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627131 p.Ala73Lys missense_variant 0.22 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627146 c.204C>T synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627149 c.-536G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.16 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.22 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.25 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.25 rifampicin
rpoA 3877647 c.861C>T synonymous_variant 0.28 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.28 rifampicin
rpoA 3877677 c.831G>T synonymous_variant 0.27 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877685 c.823C>T synonymous_variant 0.28 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877689 c.819C>G synonymous_variant 0.28 rifampicin
rpoA 3877692 c.816G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>A synonymous_variant 0.3 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.29 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877788 c.720G>A synonymous_variant 0.22 rifampicin
rpoA 3877803 c.705G>T synonymous_variant 0.22 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877827 c.681C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.23 rifampicin
rpoA 3877860 c.648C>T synonymous_variant 0.23 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.23 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.24 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.2 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.22 rifampicin
rpoA 3877905 c.603A>C synonymous_variant 0.21 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.18 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.16 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.19 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.25 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.27 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878166 c.342C>G synonymous_variant 0.32 rifampicin
rpoA 3878175 c.333G>C synonymous_variant 0.35 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.36 rifampicin Uncertain significance
rpoA 3878202 c.306G>C synonymous_variant 0.36 rifampicin
rpoA 3878205 c.303T>A synonymous_variant 0.35 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.33 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.33 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.35 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.35 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.29 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.27 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.22 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.22 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.23 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.22 rifampicin
rpoA 3878358 c.150C>G synonymous_variant 0.22 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.24 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.24 rifampicin
rpoA 3878394 c.114G>T synonymous_variant 0.22 rifampicin
rpoA 3878400 c.108T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
ddn 3986615 c.-229C>T upstream_gene_variant 0.28 delamanid
pretomanid
ddn 3986633 c.-211C>G upstream_gene_variant 0.26 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.26 delamanid
pretomanid
ddn 3986661 c.-183C>A upstream_gene_variant 0.22 delamanid
pretomanid
ddn 3986663 c.-180_-177delAGCC upstream_gene_variant 0.2 delamanid
pretomanid
ddn 3986687 c.-157C>T upstream_gene_variant 0.17 delamanid
pretomanid
ddn 3986696 c.-148G>A upstream_gene_variant 0.14 delamanid
pretomanid
clpC1 4038587 c.2118C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038620 p.Gln695Leu missense_variant 0.2 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.21 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.22 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.21 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.2 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038670 c.2035C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038671 c.2034T>A synonymous_variant 0.2 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.21 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038704 c.2001T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038726 p.Thr660Cys missense_variant 0.19 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4038773 c.1932T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.33 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038809 p.Gln632Ala missense_variant 0.26 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038875 c.1830C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038881 c.1824C>T synonymous_variant 0.24 pyrazinamide
clpC1 4038890 c.1815G>A synonymous_variant 0.25 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.22 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.21 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1702_1704delAACinsGG frameshift_variant&missense_variant 0.27 pyrazinamide
clpC1 4039004 c.1701C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039067 c.1638G>T synonymous_variant 0.35 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.39 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039119 c.1585_1586delTCinsAG synonymous_variant 0.33 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.3 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039222 p.Pro495Ala missense_variant 0.71 pyrazinamide
clpC1 4039265 c.1440C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039280 c.1425G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039286 c.1419T>G synonymous_variant 0.25 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.16 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039358 c.1347C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.14 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039412 c.1293T>A synonymous_variant 0.23 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.23 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039439 c.1266C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039472 c.1233G>T synonymous_variant 0.29 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.29 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Ser missense_variant 0.28 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039581 p.Thr375Ser missense_variant 0.3 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039601 c.1104G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039655 c.1050G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039694 c.1011G>A synonymous_variant 0.31 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039733 c.972G>T synonymous_variant 0.28 pyrazinamide
clpC1 4039736 c.969C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039754 c.951G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.29 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039855 c.850C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039886 c.819C>T synonymous_variant 0.41 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039925 c.780C>T synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.37 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.36 pyrazinamide
clpC1 4040001 p.His235Ala missense_variant 0.34 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040057 c.648C>T synonymous_variant 0.35 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040144 c.561G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040159 c.546G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040168 c.537G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.35 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.35 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.34 pyrazinamide
clpC1 4040213 c.492T>G synonymous_variant 0.34 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.34 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040237 c.468C>A synonymous_variant 0.3 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.26 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.25 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.427_429delTCCinsAGT synonymous_variant 0.21 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040312 c.393G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040315 p.Glu130Asp missense_variant 0.21 pyrazinamide
clpC1 4040321 c.384C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040336 c.369G>T synonymous_variant 0.2 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.19 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.26 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040432 c.273C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040444 c.261C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.3 pyrazinamide
clpC1 4040539 c.166C>T synonymous_variant 0.27 pyrazinamide
clpC1 4040540 c.165G>T synonymous_variant 0.27 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040552 c.153G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.3 pyrazinamide
clpC1 4040582 c.123G>T synonymous_variant 0.27 pyrazinamide
clpC1 4040585 c.120A>G synonymous_variant 0.28 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.26 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.26 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040618 c.87C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.21 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.14 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
panD 4044147 c.135C>G synonymous_variant 0.19 pyrazinamide
panD 4044150 c.132A>C synonymous_variant 0.17 pyrazinamide
panD 4044156 c.126A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
panD 4044159 c.123C>T synonymous_variant 0.16 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.17 pyrazinamide
panD 4044189 c.93C>T synonymous_variant 0.14 pyrazinamide
glpK 4138649 c.1107C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138655 c.1101G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138661 c.1095T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138676 c.1080T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138682 c.1074C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138696 p.Pro354Ala missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138697 c.1059C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138712 c.1042_1044delGCGinsTC frameshift_variant&missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138718 p.Ser346Val missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1030_1032delGCAinsAG frameshift_variant&missense_variant 0.17 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138751 c.1005T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4241050 c.1188T>G synonymous_variant 0.14 ethambutol
embC 4241053 c.1191G>T synonymous_variant 0.15 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.19 ethambutol
embC 4241084 p.Leu408Ala missense_variant 0.2 ethambutol
embC 4241135 p.Val425Leu missense_variant 0.22 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241158 c.1296T>C synonymous_variant 0.17 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241162 p.Leu434Met missense_variant 0.17 ethambutol
embC 4241167 c.1305C>G synonymous_variant 0.17 ethambutol
embC 4241179 c.1317G>C synonymous_variant 0.17 ethambutol
embC 4242411 p.Val850Ala missense_variant 0.98 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247467 c.954C>T synonymous_variant 0.15 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.17 ethambutol
embB 4247476 c.963C>T synonymous_variant 0.15 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.2 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.21 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.21 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R