TB-Profiler result

Run: SRR25827418
Summary

Run ID: SRR25827418

Sample name:

Date: 2024-04-15T11:00:47.487456

Number of reads: 5550773

Percentage reads mapped: 91.88

Median coverage: 176.0

Strain: lineage3.1;lineage9

Spoligotype:

Drug-resistance: XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.94
lineage9 Lineage 9 None 0.18
La1.7.1 M.bovis None 0.14
lineage3.1 East-African-Indian RD750 0.3
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
p.Ala356Val Uncertain significance Mutation from literature
pyrazinamide pncA p.Cys14* Assoc w R
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
n.906A>G Uncertain significance Mutation from literature
gid c.351delG Assoc w R
fluoroquinolones
moxifloxacin gyrA p.Asp94Gly Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Asp94Gly Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine mmpR5 c.144dupC Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
para-aminosalicylic_acid
delamanid fbiC c.643_645delCTGinsTA Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1018_1020delGGCinsCT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1270_1272delCTGinsTT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiB c.1150_1152delTTGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1288_1290delGACinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline mmpR5 c.144dupC Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7582 p.Asp94Gly missense_variant 0.59 levofloxacin Assoc w R
moxifloxacin Assoc w R High-level resistance
rpoB 761155 p.Ser450Leu missense_variant 0.76 rifampicin Assoc w R
mmpR5 779130 c.144dupC frameshift_variant 1.0 bedaquiline Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
clofazimine Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
fbiC 1303573 c.643_645delCTGinsTA frameshift_variant&stop_gained 0.6 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303948 c.1018_1020delGGCinsCT frameshift_variant&missense_variant 0.33 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304200 c.1270_1272delCTGinsTT frameshift_variant&synonymous_variant 0.38 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.31 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance Mutation from literature
rrs 1472751 n.906A>G non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2289200 p.Cys14* stop_gained 1.0 pyrazinamide Assoc w R
fbiB 3642684 c.1150_1152delTTGinsCC frameshift_variant&missense_variant 0.3 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiB 3642822 c.1288_1290delGACinsCG frameshift_variant&missense_variant 0.24 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247429 p.Met306Val missense_variant 0.57 ethambutol Assoc w R
embB 4247580 p.Ala356Val missense_variant 0.29 ethambutol Uncertain significance Mutation from literature
gid 4407851 c.351delG frameshift_variant 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 795 c.795A>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.32 isoniazid Uncertain significance
dnaA 822 c.822A>G synonymous_variant 0.36 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.37 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.38 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.38 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.39 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.39 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 876 c.876C>G synonymous_variant 0.37 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.36 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.36 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.38 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.37 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.4 isoniazid
dnaA 927 c.927G>A synonymous_variant 0.4 isoniazid
dnaA 930 c.930G>A synonymous_variant 0.38 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.41 isoniazid
dnaA 954 c.954G>C synonymous_variant 0.4 isoniazid
dnaA 960 c.960C>G synonymous_variant 0.37 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.36 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.36 isoniazid
dnaA 981 c.981C>T synonymous_variant 0.41 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>C synonymous_variant 0.42 isoniazid
dnaA 993 c.993A>G synonymous_variant 0.41 isoniazid
dnaA 996 c.996A>T synonymous_variant 0.42 isoniazid
dnaA 999 c.999C>A synonymous_variant 0.42 isoniazid
dnaA 1005 c.1005G>A synonymous_variant 0.44 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.46 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.47 isoniazid
dnaA 1050 c.1050G>T synonymous_variant 0.49 isoniazid
dnaA 1056 c.1056G>C synonymous_variant 0.49 isoniazid Not assoc w R - Interim
dnaA 1059 c.1059C>G synonymous_variant 0.5 isoniazid
dnaA 1080 c.1080C>G synonymous_variant 0.48 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.45 isoniazid Not assoc w R - Interim
dnaA 1101 c.1101C>T synonymous_variant 0.42 isoniazid Not assoc w R - Interim
dnaA 1110 c.1110T>C synonymous_variant 0.43 isoniazid
dnaA 1122 c.1122C>T synonymous_variant 0.38 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.36 isoniazid
dnaA 1128 c.1128G>C synonymous_variant 0.37 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.39 isoniazid
dnaA 1149 c.1149C>T synonymous_variant 0.37 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.36 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.33 isoniazid
dnaA 1164 c.1164A>G synonymous_variant 0.33 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.34 isoniazid
dnaA 1191 c.1191T>A synonymous_variant 0.29 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.29 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.27 isoniazid
dnaA 1215 c.1215C>T synonymous_variant 0.23 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.24 isoniazid
dnaA 1224 c.1224C>G synonymous_variant 0.27 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.28 isoniazid
dnaA 1237 p.Ala413Ser missense_variant 0.29 isoniazid
dnaA 1242 c.1242G>A synonymous_variant 0.3 isoniazid
dnaA 1254 c.1254T>G synonymous_variant 0.33 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.31 isoniazid
dnaA 1281 c.1281C>G synonymous_variant 0.31 isoniazid
dnaA 1291 c.1291_1293delCTTinsTG frameshift_variant&missense_variant 0.31 isoniazid Uncertain significance
dnaA 1299 c.1299G>C synonymous_variant 0.31 isoniazid Not assoc w R - Interim
dnaA 1308 c.1308G>A synonymous_variant 0.31 isoniazid
dnaA 1323 c.1323C>T synonymous_variant 0.3 isoniazid Not assoc w R - Interim
dnaA 1329 c.1329A>G synonymous_variant 0.3 isoniazid
dnaA 1332 c.1332A>G synonymous_variant 0.28 isoniazid
dnaA 1338 c.1338T>C synonymous_variant 0.27 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.25 isoniazid
dnaA 1356 c.1356T>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 1371 c.1371T>C synonymous_variant 0.21 isoniazid
gyrB 6091 c.852G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6100 c.861G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6142 c.903G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6151 c.912C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrB 6169 c.930C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrB 6175 c.936G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6178 c.939C>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6205 c.966C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrB 6209 c.970C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrB 6214 c.975G>A synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.37 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>T synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6280 c.1041T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6310 c.-992G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6313 c.-989C>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7072 c.-230G>A upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7093 c.-209T>A upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7156 c.1917C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7165 c.-137C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 7166 p.Ala643Ser missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7171 c.-131C>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7394 c.93T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7418 c.117C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7448 c.147G>A synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7587 c.286C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7619 c.318C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7622 c.321C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7637 c.336C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7643 c.342C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7649 c.348C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8213 c.912C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8231 c.930C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8240 c.939C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8252 c.951G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8294 c.993T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8354 c.1053G>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8360 c.1059G>A synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8367 c.1066C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8387 c.1086C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8402 p.Asp367Glu missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8408 c.1107A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8432 c.1131C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8666 c.1365G>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8690 c.1389C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8726 c.1425G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Lys missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8752 p.Ala484Gly missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8762 c.1461G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8793 p.Ile498Val missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8825 c.1524G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8912 c.1611G>A synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8918 c.1617C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8924 c.1623C>A synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8930 c.1629C>T synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 8983 p.Cys561Ser missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>T synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.46 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9047 c.1746C>T synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R
gyrA 9050 p.Asp583Glu missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9065 c.1764C>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>A synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9107 c.1806C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9125 c.1824C>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.28 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9146 c.1845C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9149 c.1848C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 9161 c.1860C>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9185 c.1884C>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>T synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9206 c.1905C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9212 c.1911G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>G synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.49 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9258 c.1957C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9269 c.1968C>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 9272 c.1971C>T synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9284 c.1983T>G synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9311 c.2010C>T synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 9312 c.2011C>T synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>A synonymous_variant 0.55 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.51 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9419 c.2118T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9420 p.Ile707Ala missense_variant 0.47 levofloxacin
moxifloxacin
gyrA 9431 c.2130G>A synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 9441 c.2140C>T synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9449 c.2148C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 9452 c.2151G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9455 c.2154T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 9464 c.2163C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9467 c.2166T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9476 c.2175G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9485 c.2184A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9488 c.2187G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9497 c.2196G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9503 c.2202T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9508 p.Ala736Gly missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9518 c.2217A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9521 c.2220C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9536 c.2235C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9542 c.2241T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9545 c.2244A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9548 c.2247T>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9551 c.2250G>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9557 c.2256G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9572 c.2271C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9575 c.2274G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9578 c.2277C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9585 c.2284_2286delTTGinsCC frameshift_variant&missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 9590 c.2289T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9593 c.2292G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9626 c.2325T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9629 c.2328C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9630 p.Val777Ile missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 9635 c.2334T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9641 c.2340C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9644 c.2343T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9650 c.2349G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9659 c.2358C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
Rv0010c 13771 c.-213T>C upstream_gene_variant 0.41 isoniazid
Rv0010c 13780 c.-222C>G upstream_gene_variant 0.41 isoniazid
Rv0010c 13789 c.-233_-231delCAAinsGG upstream_gene_variant 0.41 isoniazid
Rv0010c 13792 c.-234G>T upstream_gene_variant 0.41 isoniazid
Rv0010c 13803 c.-245A>C upstream_gene_variant 0.4 isoniazid
Rv0010c 13804 c.-246C>G upstream_gene_variant 0.4 isoniazid
Rv0010c 13810 c.-252A>G upstream_gene_variant 0.39 isoniazid
Rv0010c 13816 c.-258C>G upstream_gene_variant 0.38 isoniazid
Rv0010c 13819 c.-263_-261delCAAinsAT upstream_gene_variant 0.38 isoniazid
Rv0010c 13828 c.-272_-270delATTinsGA upstream_gene_variant 0.37 isoniazid
Rv0010c 13834 c.-276A>C upstream_gene_variant 0.4 isoniazid
Rv0010c 13839 c.-281T>C upstream_gene_variant 0.42 isoniazid
Rv0010c 13852 c.-294A>G upstream_gene_variant 0.43 isoniazid
Rv0010c 13864 c.-306A>C upstream_gene_variant 0.42 isoniazid
Rv0010c 13878 c.-320C>T upstream_gene_variant 0.34 isoniazid
Rv0010c 13891 c.-335_-333delTCGinsGC upstream_gene_variant 0.27 isoniazid
fgd1 491043 c.261T>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491058 c.276C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491064 c.282A>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491073 c.291C>T synonymous_variant 0.32 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491079 c.297C>T synonymous_variant 0.31 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491082 c.300T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491085 c.303T>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491136 c.354C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491142 c.360C>T synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491388 c.606C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491491 p.Pro237Thr missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491553 c.771G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491604 c.822G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491613 c.831C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491652 c.870C>T synonymous_variant 0.3 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491664 c.882C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491688 c.906A>G synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491694 c.912C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491709 c.927A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491712 c.930T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491718 c.936A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 574574 c.-774A>G upstream_gene_variant 0.2 ethionamide
isoniazid
mshA 574595 c.-753A>G upstream_gene_variant 0.21 ethionamide
isoniazid
mshA 574604 c.-744C>G upstream_gene_variant 0.26 ethionamide
isoniazid
mshA 574631 c.-717C>G upstream_gene_variant 0.33 ethionamide
isoniazid
mshA 574637 c.-711C>G upstream_gene_variant 0.34 ethionamide
isoniazid
mshA 574640 c.-708G>A upstream_gene_variant 0.35 ethionamide
isoniazid
mshA 574643 c.-705C>T upstream_gene_variant 0.35 ethionamide
isoniazid
mshA 574650 c.-698A>C upstream_gene_variant 0.38 ethionamide
isoniazid
mshA 574667 c.-681G>T upstream_gene_variant 0.38 ethionamide
isoniazid
mshA 574673 c.-675A>G upstream_gene_variant 0.38 ethionamide
isoniazid
mshA 574676 c.-672G>C upstream_gene_variant 0.38 ethionamide
isoniazid
mshA 574678 c.-670G>C upstream_gene_variant 0.37 ethionamide
isoniazid
mshA 574683 c.-665T>C upstream_gene_variant 0.39 ethionamide
isoniazid Uncertain significance
mshA 574688 c.-660G>C upstream_gene_variant 0.42 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 574694 c.-654C>G upstream_gene_variant 0.44 ethionamide
isoniazid
mshA 574718 c.-630A>G upstream_gene_variant 0.4 ethionamide
isoniazid
mshA 574721 c.-627C>G upstream_gene_variant 0.39 ethionamide
isoniazid
mshA 574731 c.-617A>G upstream_gene_variant 0.4 ethionamide
isoniazid
mshA 574742 c.-606G>A upstream_gene_variant 0.41 ethionamide
isoniazid
mshA 574763 c.-585T>C upstream_gene_variant 0.31 ethionamide
isoniazid Uncertain significance
mshA 574766 c.-582T>C upstream_gene_variant 0.3 ethionamide
isoniazid Uncertain significance
mshA 574769 c.-579C>A upstream_gene_variant 0.3 ethionamide
isoniazid Uncertain significance
mshA 574782 c.-566C>G upstream_gene_variant 0.28 ethionamide
isoniazid
mshA 574790 c.-558C>G upstream_gene_variant 0.22 ethionamide
isoniazid
mshA 574792 c.-556T>C upstream_gene_variant 0.21 ethionamide
isoniazid
mshA 574952 c.-396A>G upstream_gene_variant 0.2 ethionamide
isoniazid
mshA 574955 c.-393A>C upstream_gene_variant 0.22 ethionamide
isoniazid
mshA 574961 c.-387T>C upstream_gene_variant 0.25 ethionamide
isoniazid Uncertain significance
mshA 574970 c.-378A>G upstream_gene_variant 0.29 ethionamide
isoniazid
mshA 574979 c.-369G>T upstream_gene_variant 0.29 ethionamide
isoniazid
mshA 574980 c.-368C>T upstream_gene_variant 0.29 ethionamide
isoniazid Uncertain significance
mshA 575000 c.-348C>G upstream_gene_variant 0.31 ethionamide
isoniazid
mshA 575009 c.-339T>C upstream_gene_variant 0.3 ethionamide
isoniazid
mshA 575011 c.-337G>A upstream_gene_variant 0.29 ethionamide
isoniazid
mshA 575015 c.-333G>C upstream_gene_variant 0.29 ethionamide
isoniazid
mshA 575022 c.-326C>T upstream_gene_variant 0.3 ethionamide
isoniazid
mshA 575030 c.-318T>C upstream_gene_variant 0.29 ethionamide
isoniazid
mshA 575034 c.-314_-312delTTAinsCG upstream_gene_variant 0.3 ethionamide
isoniazid
mshA 575042 c.-306T>C upstream_gene_variant 0.3 ethionamide
isoniazid
mshA 575051 c.-297A>G upstream_gene_variant 0.29 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575052 c.-296G>C upstream_gene_variant 0.29 ethionamide
isoniazid
mshA 575060 c.-288G>C upstream_gene_variant 0.29 ethionamide
isoniazid
mshA 575063 c.-285T>C upstream_gene_variant 0.29 ethionamide
isoniazid
mshA 575075 c.-273T>C upstream_gene_variant 0.24 ethionamide
isoniazid Uncertain significance
mshA 575695 c.348C>G synonymous_variant 0.32 ethionamide
isoniazid Not assoc w R - Interim
mshA 575705 c.358T>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.38 ethionamide
isoniazid
mshA 575720 c.373C>T synonymous_variant 0.4 ethionamide
isoniazid
mshA 575725 c.378C>G synonymous_variant 0.41 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.43 ethionamide
isoniazid
mshA 575767 c.420G>A synonymous_variant 0.49 ethionamide
isoniazid
mshA 575770 c.423G>C synonymous_variant 0.49 ethionamide
isoniazid
mshA 575772 p.Val142Ala missense_variant 0.5 ethionamide
isoniazid
mshA 575782 c.435G>T synonymous_variant 0.51 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575785 c.438T>G synonymous_variant 0.51 ethionamide
isoniazid
mshA 575786 p.Tyr147His missense_variant 0.51 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.53 ethionamide
isoniazid Not assoc w R - Interim
mshA 575821 c.474G>C synonymous_variant 0.52 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.53 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.52 ethionamide
isoniazid Not assoc w R - Interim
mshA 575878 c.531A>G synonymous_variant 0.48 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.43 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.39 ethionamide
isoniazid
mshA 575909 c.562C>T synonymous_variant 0.38 ethionamide
isoniazid
mshA 575915 p.Asp190His missense_variant 0.39 ethionamide
isoniazid
mshA 575923 c.576C>T synonymous_variant 0.38 ethionamide
isoniazid
mshA 575924 p.Gly193Thr missense_variant 0.37 ethionamide
isoniazid
mshA 575947 c.600G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575953 c.606G>C synonymous_variant 0.31 ethionamide
isoniazid
mshA 575956 c.609G>A synonymous_variant 0.3 ethionamide
isoniazid
mshA 575965 c.618C>T synonymous_variant 0.3 ethionamide
isoniazid
ccsA 619507 c.-384A>G upstream_gene_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 619528 c.-363C>G upstream_gene_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 619532 c.-359C>G upstream_gene_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 619537 c.-354A>G upstream_gene_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 619544 c.-347A>C upstream_gene_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 619549 c.-342C>T upstream_gene_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 619552 c.-338_-330delGGCCCGGCG upstream_gene_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 619563 c.-328C>A upstream_gene_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 619573 c.-318G>C upstream_gene_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>A upstream_gene_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 619633 c.-258G>A upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620166 c.276G>C synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620173 c.283_285delGTCinsAT frameshift_variant&missense_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620187 c.297C>T synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620197 p.Gln103Met missense_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620226 c.336G>A synonymous_variant 0.47 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620257 p.Ile123Val missense_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>T synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620269 p.Val127Ile missense_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620275 c.385C>T synonymous_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620280 c.390C>T synonymous_variant 0.5 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620283 c.393T>C synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.51 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.52 capreomycin
amikacin
kanamycin
ccsA 620316 c.426G>C synonymous_variant 0.47 capreomycin
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620317 c.427_429delGTCinsCT frameshift_variant&missense_variant 0.46 capreomycin
amikacin
kanamycin
ccsA 620331 c.441C>T synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620332 c.442C>T synonymous_variant 0.49 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620379 c.489G>A synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.27 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620427 c.537C>A synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620436 c.546T>C synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>G synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620442 c.552G>A synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620598 c.708C>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620613 c.723C>T synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>A synonymous_variant 0.23 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620631 c.741T>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620676 c.786C>T synonymous_variant 0.23 capreomycin
amikacin
kanamycin
Rv0565c 656299 p.Thr391Val missense_variant 0.25 ethionamide
Rv0565c 656301 c.1170C>T synonymous_variant 0.25 ethionamide
Rv0565c 656304 c.1167T>C synonymous_variant 0.26 ethionamide
Rv0565c 656310 c.1161T>C synonymous_variant 0.27 ethionamide
Rv0565c 656358 c.1113T>C synonymous_variant 0.29 ethionamide Not assoc w R - Interim
Rv0565c 656364 c.1107T>C synonymous_variant 0.28 ethionamide
Rv0565c 656367 p.Arg368Thr missense_variant 0.27 ethionamide
Rv0565c 656370 c.1101T>C synonymous_variant 0.27 ethionamide
Rv0565c 656373 c.1098C>T synonymous_variant 0.28 ethionamide
Rv0565c 656379 p.Glu364Asp missense_variant 0.31 ethionamide
Rv0565c 656402 p.Ala357Thr missense_variant 0.28 ethionamide
Rv0565c 656406 c.1065G>C synonymous_variant 0.28 ethionamide
Rv0565c 656415 c.1056G>C synonymous_variant 0.26 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.25 ethionamide
Rv0565c 656423 c.1048T>C synonymous_variant 0.24 ethionamide
Rv0565c 656436 c.1035C>G synonymous_variant 0.23 ethionamide
Rv0565c 656448 c.1023T>C synonymous_variant 0.2 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657233 p.Ile80Val missense_variant 0.21 ethionamide
Rv0565c 657240 p.Glu77Asp missense_variant 0.23 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.21 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.22 ethionamide
hadA 731687 c.-243G>A upstream_gene_variant 0.32 isoniazid
hadA 731689 c.-241A>G upstream_gene_variant 0.31 isoniazid
hadA 731692 c.-237_-236delCT upstream_gene_variant 0.32 isoniazid
hadA 731698 c.-232_-231insTGACACCTGATTTG upstream_gene_variant 0.31 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.33 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.33 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.33 isoniazid
hadA 731729 c.-201C>T upstream_gene_variant 0.39 isoniazid
hadA 731753 c.-177A>C upstream_gene_variant 0.37 isoniazid
hadA 731756 c.-174C>T upstream_gene_variant 0.35 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.3 isoniazid
hadA 731831 c.-99G>A upstream_gene_variant 0.36 isoniazid
hadA 731839 c.-91_-90delCGinsGC upstream_gene_variant 0.35 isoniazid
hadA 731849 c.-81C>A upstream_gene_variant 0.37 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.36 isoniazid
hadA 731876 c.-54G>T upstream_gene_variant 0.31 isoniazid
hadA 731879 c.-51A>G upstream_gene_variant 0.31 isoniazid
hadA 731881 c.-49C>T upstream_gene_variant 0.3 isoniazid
hadA 731882 c.-48G>C upstream_gene_variant 0.31 isoniazid
hadA 731883 c.-47C>A upstream_gene_variant 0.31 isoniazid
hadA 731891 c.-39C>T upstream_gene_variant 0.3 isoniazid Uncertain significance
hadA 731899 c.-31T>C upstream_gene_variant 0.3 isoniazid
hadA 731900 c.-30G>A upstream_gene_variant 0.29 isoniazid
hadA 731902 c.-28T>A upstream_gene_variant 0.3 isoniazid
hadA 731903 c.-27G>C upstream_gene_variant 0.3 isoniazid
hadA 731925 c.-5C>G upstream_gene_variant 0.28 isoniazid
hadA 731935 c.6G>C synonymous_variant 0.24 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.23 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.22 isoniazid
hadA 732329 c.400_402delCTCinsAT frameshift_variant&missense_variant 0.23 isoniazid Uncertain significance
hadA 732346 c.417T>C synonymous_variant 0.29 isoniazid
hadA 732370 c.441C>T synonymous_variant 0.37 isoniazid
hadA 732376 c.447T>C synonymous_variant 0.36 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.37 isoniazid
nusG 734337 c.84G>C synonymous_variant 0.21 rifampicin
nusG 734347 p.Val32Leu missense_variant 0.22 rifampicin
nusG 734352 c.99T>C synonymous_variant 0.23 rifampicin
nusG 734355 c.102G>A synonymous_variant 0.22 rifampicin
nusG 734358 c.105C>G synonymous_variant 0.24 rifampicin
nusG 734370 c.117A>G synonymous_variant 0.3 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.33 rifampicin
nusG 734394 c.141C>G synonymous_variant 0.34 rifampicin
nusG 734409 c.156T>G synonymous_variant 0.3 rifampicin
nusG 734415 c.162C>A synonymous_variant 0.3 rifampicin
nusG 734418 c.165C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734421 c.168A>G synonymous_variant 0.3 rifampicin
nusG 734424 c.171G>T synonymous_variant 0.31 rifampicin
nusG 734436 c.183G>A synonymous_variant 0.36 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.35 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.37 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.39 rifampicin
nusG 734457 c.204C>T synonymous_variant 0.4 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.4 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734535 c.282C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.26 rifampicin
nusG 734565 c.312G>A synonymous_variant 0.26 rifampicin
nusG 734574 c.321C>G synonymous_variant 0.23 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734841 c.588G>A synonymous_variant 0.35 rifampicin
nusG 734844 c.591G>T synonymous_variant 0.35 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.36 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.36 rifampicin
nusG 734862 c.609C>G synonymous_variant 0.38 rifampicin
nusG 734868 c.615C>T synonymous_variant 0.39 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.43 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.47 rifampicin
nusG 734940 c.687G>A synonymous_variant 0.52 rifampicin
nusG 734950 p.Gly233Ser missense_variant 0.52 rifampicin
nusG 734955 c.702A>G synonymous_variant 0.52 rifampicin
rpoB 759746 c.-61C>T upstream_gene_variant 0.96 rifampicin Not assoc w R
rpoB 759991 p.Pro62Gln missense_variant 0.21 rifampicin
rpoB 760040 c.234T>C synonymous_variant 0.21 rifampicin
rpoB 760046 c.240G>C synonymous_variant 0.21 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.23 rifampicin
rpoB 760088 c.282C>G synonymous_variant 0.23 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>T synonymous_variant 0.27 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.26 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.29 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760199 c.393C>T synonymous_variant 0.43 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.49 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760241 c.435G>C synonymous_variant 0.51 rifampicin
rpoB 760244 c.438G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760262 c.456G>C synonymous_variant 0.51 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.52 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.49 rifampicin Uncertain significance
rpoB 760403 c.597C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>A synonymous_variant 0.46 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760454 c.648C>G synonymous_variant 0.44 rifampicin
rpoB 760457 c.651C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>A synonymous_variant 0.46 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760490 c.684C>G synonymous_variant 0.4 rifampicin
rpoB 760508 c.702G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760521 p.Ser239Gly missense_variant 0.36 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.33 rifampicin
rpoB 760547 c.741G>A synonymous_variant 0.3 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.24 rifampicin Uncertain significance
rpoB 760601 c.795C>T synonymous_variant 0.21 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760674 c.868T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760703 c.897C>G synonymous_variant 0.38 rifampicin
rpoB 760721 c.915C>T synonymous_variant 0.42 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760757 c.951T>C synonymous_variant 0.42 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.41 rifampicin
rpoB 760763 c.957C>T synonymous_variant 0.41 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.42 rifampicin
rpoB 760784 c.978G>A synonymous_variant 0.4 rifampicin
rpoB 760790 c.984C>A synonymous_variant 0.39 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.38 rifampicin
rpoB 760811 c.1005C>G synonymous_variant 0.37 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.36 rifampicin
rpoB 760826 c.1020C>T synonymous_variant 0.36 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.29 rifampicin
rpoB 760848 p.Thr348Ser missense_variant 0.27 rifampicin
rpoB 760856 c.1050C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.26 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.19 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.2 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760994 c.1188G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.31 rifampicin
rpoB 761024 c.1218C>T synonymous_variant 0.31 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761030 c.1224G>C synonymous_variant 0.32 rifampicin
rpoB 761037 c.1231T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.25 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.25 rifampicin
rpoB 761124 c.1318C>T synonymous_variant 0.26 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761159 c.1353G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.24 rifampicin
rpoB 761180 c.1374A>G synonymous_variant 0.25 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.31 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761252 c.1446C>T synonymous_variant 0.23 rifampicin
rpoB 761255 c.1449T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>A synonymous_variant 0.24 rifampicin
rpoB 761561 c.1755C>G synonymous_variant 0.25 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.29 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.28 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.24 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>A synonymous_variant 0.28 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.28 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.31 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.29 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.33 rifampicin
rpoB 761723 c.1917_1919delAGAinsG frameshift_variant&synonymous_variant 0.33 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.32 rifampicin
rpoB 761744 c.1938G>A synonymous_variant 0.33 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.34 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.35 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.36 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.34 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.33 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.33 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.34 rifampicin
rpoB 761819 c.2013G>T synonymous_variant 0.35 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.32 rifampicin
rpoB 761837 c.2031C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761848 p.Cys681Ser missense_variant 0.28 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.28 rifampicin
rpoB 761864 c.2058G>T synonymous_variant 0.33 rifampicin
rpoB 761867 c.2061C>A synonymous_variant 0.33 rifampicin
rpoB 761870 c.2064C>T synonymous_variant 0.33 rifampicin
rpoB 761882 c.2076C>A synonymous_variant 0.37 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.39 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.44 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.44 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.43 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.44 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.45 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762011 c.2205G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.34 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762110 c.2304G>T synonymous_variant 0.31 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.29 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.3 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.29 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.28 rifampicin
rpoB 762149 c.2343G>A synonymous_variant 0.29 rifampicin
rpoB 762158 c.2352G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.37 rifampicin
rpoB 762249 c.2443C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.44 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.43 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.43 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.54 rifampicin
rpoB 762338 c.2532T>C synonymous_variant 0.53 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.53 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.53 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.51 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.44 rifampicin
rpoB 762396 c.2590_2592delCGTinsAG frameshift_variant&missense_variant 0.44 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.46 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.46 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 0.54 rifampicin Not assoc w R
rpoB 762449 c.2643C>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>A upstream_gene_variant 0.31 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.31 rifampicin
rpoC 762524 c.-846G>C upstream_gene_variant 0.34 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.34 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.33 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.33 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.33 rifampicin
rpoC 762545 c.-825C>G upstream_gene_variant 0.33 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.34 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.32 rifampicin
rpoC 762582 c.-788T>C upstream_gene_variant 0.31 rifampicin
rpoC 762587 c.-783G>A upstream_gene_variant 0.3 rifampicin
rpoC 762596 c.-774G>T upstream_gene_variant 0.27 rifampicin
rpoB 762599 c.2793T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762602 c.2797delT frameshift_variant 0.24 rifampicin
rpoB 762607 p.Ala934Gly missense_variant 0.24 rifampicin
rpoB 762613 c.2807_2808insTC frameshift_variant 0.23 rifampicin
rpoC 762617 c.-753C>G upstream_gene_variant 0.25 rifampicin
rpoB 762634 p.Ala943Gly missense_variant 0.29 rifampicin
rpoB 762638 p.Lys944Asn missense_variant 0.29 rifampicin Uncertain significance
rpoC 762660 c.-710A>C upstream_gene_variant 0.31 rifampicin
rpoB 762674 p.Glu956Asp missense_variant 0.29 rifampicin
rpoC 762680 c.-690C>G upstream_gene_variant 0.28 rifampicin
rpoB 762681 c.2875_2877delGAGinsCC frameshift_variant&missense_variant 0.28 rifampicin
rpoB 762687 p.Gln961Glu missense_variant 0.3 rifampicin
rpoC 762701 c.-669T>C upstream_gene_variant 0.29 rifampicin
rpoB 762725 c.2919C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 762728 c.-642C>G upstream_gene_variant 0.31 rifampicin
rpoC 762749 c.-621C>G upstream_gene_variant 0.3 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762759 p.Cys985Ala missense_variant 0.3 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.27 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.29 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.3 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.3 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762851 c.-519C>T upstream_gene_variant 0.42 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762926 c.3120C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.37 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763127 c.-243G>A upstream_gene_variant 0.31 rifampicin
rpoB 763130 c.3324G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763136 c.-234C>A upstream_gene_variant 0.31 rifampicin
rpoC 763139 c.-231C>T upstream_gene_variant 0.3 rifampicin
rpoB 763157 c.3351G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763160 c.-210G>C upstream_gene_variant 0.26 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.23 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763247 c.-123G>A upstream_gene_variant 0.26 rifampicin
rpoC 763253 c.-117G>T upstream_gene_variant 0.28 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.29 rifampicin
rpoB 763283 c.3477T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763284 c.-86C>T upstream_gene_variant 0.31 rifampicin
rpoC 763310 c.-60C>T upstream_gene_variant 0.3 rifampicin
rpoB 763316 c.3510T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763319 c.-51T>G upstream_gene_variant 0.31 rifampicin
rpoC 763327 c.-43G>T upstream_gene_variant 0.32 rifampicin
rpoC 763330 c.-40G>T upstream_gene_variant 0.32 rifampicin
rpoC 763332 c.-38C>T upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoC 763334 c.-36C>G upstream_gene_variant 0.32 rifampicin
rpoC 763338 c.-32A>G upstream_gene_variant 0.32 rifampicin
rpoC 763339 c.-31T>C upstream_gene_variant 0.32 rifampicin
rpoC 763342 c.-28C>T upstream_gene_variant 0.32 rifampicin
rpoC 763344 c.-26A>C upstream_gene_variant 0.31 rifampicin
rpoC 763399 c.30C>T synonymous_variant 0.4 rifampicin
rpoC 763405 c.36C>T synonymous_variant 0.4 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.41 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763450 c.81G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.43 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763609 c.240C>G synonymous_variant 0.33 rifampicin
rpoC 763615 c.246G>T synonymous_variant 0.33 rifampicin
rpoC 763618 c.249C>T synonymous_variant 0.33 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.33 rifampicin
rpoC 763654 c.285C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>A synonymous_variant 0.34 rifampicin
rpoC 763708 c.339G>T synonymous_variant 0.37 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.38 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.39 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.39 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.4 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.4 rifampicin
rpoC 763771 c.402C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763781 p.Ser138Ala missense_variant 0.44 rifampicin
rpoC 763789 c.420C>T synonymous_variant 0.46 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.43 rifampicin
rpoC 763851 p.Ala161Gly missense_variant 0.42 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.42 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.41 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.41 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.39 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.38 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.37 rifampicin
rpoC 763885 c.516C>T synonymous_variant 0.37 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.38 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.4 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.36 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>A synonymous_variant 0.29 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.28 rifampicin
rpoC 763942 c.573C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.28 rifampicin
rpoC 763948 c.579G>C synonymous_variant 0.29 rifampicin
rpoC 763949 p.Arg194Lys missense_variant 0.28 rifampicin
rpoC 763963 c.594C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763996 c.627T>C synonymous_variant 0.39 rifampicin
rpoC 764011 c.642T>C synonymous_variant 0.4 rifampicin
rpoC 764015 c.646C>T synonymous_variant 0.4 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.42 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.43 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.43 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.42 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.49 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764113 c.744C>T synonymous_variant 0.5 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764143 c.774G>A synonymous_variant 0.53 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764191 c.822C>T synonymous_variant 0.57 rifampicin
rpoC 764197 c.828G>A synonymous_variant 0.59 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.59 rifampicin
rpoC 764245 c.876C>T synonymous_variant 0.6 rifampicin
rpoC 764246 c.877_879delCTCinsTG frameshift_variant&missense_variant 0.6 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.63 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.63 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>C synonymous_variant 0.67 rifampicin
rpoC 764293 c.924G>A synonymous_variant 0.66 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.67 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.67 rifampicin
rpoC 764326 c.957G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>G synonymous_variant 0.68 rifampicin
rpoC 764347 c.978G>T synonymous_variant 0.68 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764368 c.999C>G synonymous_variant 0.69 rifampicin
rpoC 764383 c.1014C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764392 c.1023C>T synonymous_variant 0.63 rifampicin
rpoC 764404 c.1035C>G synonymous_variant 0.59 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.6 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.52 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.51 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.41 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764570 c.1203_1204delGC frameshift_variant 0.32 rifampicin
rpoC 764577 c.1208delCinsGAG frameshift_variant&stop_gained&missense_variant 0.32 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.3 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764696 c.1327C>T synonymous_variant 0.27 rifampicin
rpoC 764701 c.1332C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 0.33 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.42 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.41 rifampicin Not assoc w R
rpoC 764812 c.1443C>T synonymous_variant 0.41 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.38 rifampicin
rpoC 764836 c.1467G>A synonymous_variant 0.38 rifampicin
rpoC 764839 c.1470C>A synonymous_variant 0.38 rifampicin
rpoC 764842 c.1473C>T synonymous_variant 0.38 rifampicin
rpoC 764845 c.1476C>A synonymous_variant 0.37 rifampicin
rpoC 764851 c.1482C>T synonymous_variant 0.37 rifampicin
rpoC 764854 c.1485G>T synonymous_variant 0.38 rifampicin
rpoC 764857 c.1488G>T synonymous_variant 0.38 rifampicin
rpoC 764872 c.1503A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764899 c.1530G>A synonymous_variant 0.38 rifampicin
rpoC 764932 c.1563C>G synonymous_variant 0.37 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764998 c.1629G>T synonymous_variant 0.52 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>A synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765079 c.1710T>C synonymous_variant 0.48 rifampicin
rpoC 765082 c.1713G>T synonymous_variant 0.46 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765122 c.1753C>T synonymous_variant 0.43 rifampicin
rpoC 765146 p.Pro593Glu missense_variant 0.37 rifampicin
rpoC 765151 c.1782G>T synonymous_variant 0.39 rifampicin
rpoC 765156 p.Thr596Asn missense_variant 0.39 rifampicin
rpoC 765170 p.Pro601Thr missense_variant 0.39 rifampicin
rpoC 765177 p.Ser603Asn missense_variant 0.35 rifampicin
rpoC 765181 c.1812G>C synonymous_variant 0.33 rifampicin
rpoC 765184 c.1815T>C synonymous_variant 0.33 rifampicin
rpoC 765186 p.His606Arg missense_variant 0.33 rifampicin
rpoC 765194 c.1825_1827delACTinsTG frameshift_variant&missense_variant 0.33 rifampicin
rpoC 765202 c.1833C>G synonymous_variant 0.39 rifampicin
rpoC 765208 c.1839T>C synonymous_variant 0.4 rifampicin
rpoC 765247 c.1878C>A synonymous_variant 0.46 rifampicin
rpoC 765292 c.1923G>T synonymous_variant 0.5 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.47 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.47 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Gly missense_variant 0.49 rifampicin
rpoC 765330 p.Ser654Asn missense_variant 0.49 rifampicin Uncertain significance
rpoC 765334 c.1965C>G synonymous_variant 0.5 rifampicin
rpoC 765350 c.1981_1983delGCGinsCT frameshift_variant&missense_variant 0.5 rifampicin
rpoC 765370 c.2001G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765371 c.2002C>T synonymous_variant 0.48 rifampicin
rpoC 765406 c.2037G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765409 c.2040T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>T synonymous_variant 0.43 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.43 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.34 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.32 rifampicin
rpoC 765547 c.2178C>A synonymous_variant 0.3 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.29 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.26 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.24 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.26 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.32 rifampicin
rpoC 765619 c.2250G>A synonymous_variant 0.34 rifampicin
rpoC 765625 c.2256C>T synonymous_variant 0.35 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765685 c.2316G>A synonymous_variant 0.47 rifampicin
rpoC 765688 c.2319G>A synonymous_variant 0.48 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 765752 p.Asp795Ser missense_variant 0.47 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.48 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.45 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.46 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.45 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.46 rifampicin
rpoC 765805 c.2436C>T synonymous_variant 0.45 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765856 c.2487T>C synonymous_variant 0.44 rifampicin
rpoC 765871 c.2502T>C synonymous_variant 0.43 rifampicin
rpoC 765874 c.2505G>A synonymous_variant 0.43 rifampicin
rpoC 765883 c.2514C>G synonymous_variant 0.43 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.44 rifampicin
rpoC 765898 c.2529C>A synonymous_variant 0.49 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.51 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>T synonymous_variant 0.5 rifampicin
rpoC 766012 c.2643C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.53 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.54 rifampicin
rpoC 766060 c.2691C>T synonymous_variant 0.45 rifampicin
rpoC 766066 c.2697C>A synonymous_variant 0.43 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.42 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.39 rifampicin
rpoC 766087 c.2718C>T synonymous_variant 0.39 rifampicin
rpoC 766093 c.2724C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766094 c.2725_2727delACGinsGC frameshift_variant&missense_variant 0.41 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.36 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.26 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766280 p.Ser971Gly missense_variant 0.22 rifampicin
rpoC 766312 c.2943T>G synonymous_variant 0.32 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.34 rifampicin
rpoC 766331 c.2962C>T synonymous_variant 0.38 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.45 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.49 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.52 rifampicin
rpoC 766369 c.3000C>T synonymous_variant 0.54 rifampicin
rpoC 766378 c.3009C>T synonymous_variant 0.55 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.58 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.58 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.59 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.59 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.58 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.6 rifampicin
rpoC 766488 p.Pro1040Arg missense_variant 0.41 rifampicin Uncertain significance
rpoC 766531 c.3162G>T synonymous_variant 0.57 rifampicin
rpoC 766543 c.3174C>G synonymous_variant 0.56 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.56 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.54 rifampicin
rpoC 766582 c.3213C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.53 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.5 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.49 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.38 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.41 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.41 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.4 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.45 rifampicin
rpoC 766693 c.3324C>G synonymous_variant 0.45 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.55 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.57 rifampicin
rpoC 766750 c.3381C>A synonymous_variant 0.58 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.58 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 766777 c.3408C>T synonymous_variant 0.59 rifampicin
rpoC 766783 c.3414C>T synonymous_variant 0.61 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.58 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.53 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.53 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.54 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.56 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.64 rifampicin
rpoC 766978 c.3609C>T synonymous_variant 0.66 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.67 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.62 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>T synonymous_variant 0.38 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.32 rifampicin
rpoC 767185 c.3816G>C synonymous_variant 0.31 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.29 rifampicin
rpoC 767203 c.3834C>A synonymous_variant 0.3 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>G synonymous_variant 0.3 rifampicin
rpoC 767212 c.3843G>C synonymous_variant 0.3 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781137 c.-423G>C upstream_gene_variant 0.22 streptomycin
rpsL 781138 c.-422C>G upstream_gene_variant 0.22 streptomycin
rpsL 781143 c.-417T>G upstream_gene_variant 0.22 streptomycin
rpsL 781152 c.-408G>C upstream_gene_variant 0.23 streptomycin
rpsL 781164 c.-396T>C upstream_gene_variant 0.22 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.26 streptomycin
rpsL 781608 c.49_51delAGTinsGC frameshift_variant&missense_variant 0.4 streptomycin Uncertain significance
rpsL 781646 c.87G>A synonymous_variant 0.53 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.52 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.53 streptomycin
rpsL 781679 c.120C>T synonymous_variant 0.57 streptomycin Not assoc w R - Interim
rpsL 781694 c.135G>A synonymous_variant 0.57 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.58 streptomycin
rpsL 781718 c.159C>A synonymous_variant 0.57 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.57 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.57 streptomycin
rpsL 781733 c.174G>A synonymous_variant 0.56 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.57 streptomycin
rpsL 781754 c.195G>A synonymous_variant 0.57 streptomycin Not assoc w R - Interim
rpsL 781760 c.201T>C synonymous_variant 0.58 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.58 streptomycin Not assoc w R - Interim
rpsL 781781 c.222G>C synonymous_variant 0.58 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.59 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.6 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.6 streptomycin
rpsL 781859 c.300T>A synonymous_variant 0.6 streptomycin
rpsL 781862 c.303G>T synonymous_variant 0.59 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.58 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.58 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.59 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.59 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.58 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.59 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.59 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.6 streptomycin
rplC 800516 c.-293G>C upstream_gene_variant 0.22 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.3 linezolid
rplC 800555 c.-254C>A upstream_gene_variant 0.38 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.41 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.41 linezolid
rplC 800585 c.-224T>C upstream_gene_variant 0.41 linezolid
rplC 800588 c.-221C>T upstream_gene_variant 0.42 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.43 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.43 linezolid
rplC 800609 c.-200G>A upstream_gene_variant 0.42 linezolid
rplC 800610 c.-199_-197delCTAinsTG upstream_gene_variant 0.42 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.44 linezolid
rplC 800621 c.-188G>A upstream_gene_variant 0.43 linezolid
rplC 800642 c.-167C>T upstream_gene_variant 0.47 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.48 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.47 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.48 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.47 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.45 linezolid
rplC 800744 c.-65G>C upstream_gene_variant 0.49 linezolid
rplC 800753 c.-56C>T upstream_gene_variant 0.49 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.48 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.49 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.5 linezolid
rplC 800799 c.-10G>C upstream_gene_variant 0.44 linezolid
rplC 800801 c.-8A>G upstream_gene_variant 0.42 linezolid
rplC 800802 c.-6delA upstream_gene_variant 0.43 linezolid
rplC 800815 c.7C>A synonymous_variant 0.43 linezolid
rplC 800820 c.12G>A synonymous_variant 0.42 linezolid
rplC 800829 c.21C>G synonymous_variant 0.39 linezolid
rplC 800844 c.36T>C synonymous_variant 0.35 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.24 linezolid
rplC 801195 c.387G>C synonymous_variant 0.27 linezolid
rplC 801201 c.393C>T synonymous_variant 0.28 linezolid
rplC 801216 c.408C>T synonymous_variant 0.28 linezolid
rplC 801222 c.414T>C synonymous_variant 0.31 linezolid
rplC 801228 c.420T>C synonymous_variant 0.33 linezolid
rplC 801246 c.438C>G synonymous_variant 0.35 linezolid
rplC 801249 c.441T>A synonymous_variant 0.36 linezolid
rplC 801258 c.450C>G synonymous_variant 0.38 linezolid
rplC 801261 c.453C>T synonymous_variant 0.37 linezolid
rplC 801267 c.459A>C synonymous_variant 0.39 linezolid
rplC 801276 c.468G>T synonymous_variant 0.4 linezolid
rplC 801307 c.499_501delGCCinsTG frameshift_variant&missense_variant 0.42 linezolid
rplC 801315 c.507G>C synonymous_variant 0.42 linezolid
rplC 801324 c.516T>C synonymous_variant 0.42 linezolid
rplC 801333 c.525G>A synonymous_variant 0.39 linezolid
rplC 801338 p.Val177Ala missense_variant 0.37 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.37 linezolid
rplC 801348 c.540T>G synonymous_variant 0.37 linezolid
rplC 801357 c.549T>C synonymous_variant 0.38 linezolid
rplC 801402 c.594T>C synonymous_variant 0.42 linezolid
rplC 801405 c.597T>C synonymous_variant 0.41 linezolid
rplC 801408 c.600C>G synonymous_variant 0.42 linezolid
rplC 801426 c.618C>G synonymous_variant 0.43 linezolid
rplC 801427 p.Met207Val missense_variant 0.44 linezolid
rplC 801438 c.630T>C synonymous_variant 0.48 linezolid
rplC 801447 c.639A>G synonymous_variant 0.44 linezolid
rplC 801461 c.653G>A splice_region_variant&stop_retained_variant 0.43 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.99 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303431 c.501T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303437 c.507C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303441 c.511T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303458 c.528G>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303464 c.534A>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303470 c.540T>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303480 p.Gln184Glu missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303554 c.624G>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303557 c.627G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303587 c.657G>A synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303677 c.747C>G synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>G synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303743 c.813C>T synonymous_variant 0.59 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303746 c.816T>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.6 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1303800 c.870G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.55 clofazimine
pretomanid
delamanid
fbiC 1303844 p.Ala305Asp missense_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303869 c.939T>C synonymous_variant 0.35 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303875 c.945G>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303878 c.948G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303890 c.960G>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303932 c.1002G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303959 c.1029C>T synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303965 c.1035G>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303966 c.1036C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.4 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303998 c.1068T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304007 c.1077G>A synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304035 c.1105C>A synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304047 p.Ala373Thr missense_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304055 c.1125C>T synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304076 c.1146C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304079 c.1149A>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304091 p.Asp387Glu missense_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304104 c.1174C>T synonymous_variant 0.46 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304118 c.1188C>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.53 clofazimine
pretomanid
delamanid
fbiC 1304133 c.1203G>C synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1304172 c.1242G>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304181 c.1251G>T synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304199 c.1269C>T synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304226 c.1296C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304250 c.1320C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304970 c.2040G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304995 c.2065T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305024 c.2094C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305027 c.2097G>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305081 c.2151G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305090 c.2160C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305096 c.2166T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305102 c.2172C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305267 c.2337C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305300 c.2370A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305309 c.2379G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305310 p.Arg794Glu missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305361 c.2431C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305372 c.2442G>A synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305411 c.2481C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
sigE 1364676 c.264C>G synonymous_variant 0.33 pyrazinamide
sigE 1364685 c.273C>T synonymous_variant 0.33 pyrazinamide
sigE 1364688 c.276C>T synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
sigE 1364704 c.292C>T synonymous_variant 0.36 pyrazinamide
sigE 1364709 c.297T>C synonymous_variant 0.36 pyrazinamide
sigE 1364718 c.306C>T synonymous_variant 0.35 pyrazinamide
sigE 1364727 c.315C>T synonymous_variant 0.35 pyrazinamide
sigE 1364729 p.Gln106Pro missense_variant 0.35 pyrazinamide
sigE 1364733 p.His107Gln missense_variant 0.35 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
sigE 1364739 c.327C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.35 pyrazinamide
sigE 1364751 c.339C>G synonymous_variant 0.38 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.37 pyrazinamide
sigE 1364772 c.360G>T synonymous_variant 0.35 pyrazinamide
sigE 1364781 c.369G>C synonymous_variant 0.3 pyrazinamide
sigE 1364784 c.372C>T synonymous_variant 0.29 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.31 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.29 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.27 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.24 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.22 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.22 pyrazinamide
sigE 1364844 c.432C>T synonymous_variant 0.21 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.22 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.22 pyrazinamide
sigE 1364868 c.456T>C synonymous_variant 0.22 pyrazinamide
sigE 1364889 c.477A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
sigE 1364895 p.Glu161Asp missense_variant 0.21 pyrazinamide
embR 1416433 c.913_915delGCCinsTG frameshift_variant&missense_variant 0.27 ethambutol Uncertain significance
embR 1416450 p.Gly300Ser missense_variant 0.23 ethambutol
embR 1416454 c.894T>A synonymous_variant 0.25 ethambutol
embR 1416457 c.891G>C synonymous_variant 0.21 ethambutol
embR 1416465 p.Ile295Val missense_variant 0.2 ethambutol
embR 1416496 c.852G>C synonymous_variant 0.23 ethambutol
embR 1416499 p.Ala283Val missense_variant 0.23 ethambutol
embR 1416514 c.834T>C synonymous_variant 0.24 ethambutol
embR 1416538 c.810T>C synonymous_variant 0.24 ethambutol
embR 1416544 c.804C>A synonymous_variant 0.22 ethambutol
embR 1416547 c.801A>G synonymous_variant 0.2 ethambutol
atpE 1461071 c.27C>G synonymous_variant 0.21 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.36 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.44 bedaquiline
atpE 1461161 c.117C>T synonymous_variant 0.43 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.42 bedaquiline
atpE 1461185 c.141G>A synonymous_variant 0.42 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.41 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.35 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.31 bedaquiline
atpE 1461251 c.207G>C synonymous_variant 0.23 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473789 n.132G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1473797 n.140G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474028 n.371T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474106 n.449A>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474110 n.453A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474412 n.756_768delACCCACACGCGCA non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474428 n.771C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474431 n.774G>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474434 n.777_778insAAGGG non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474437 n.781_782delAA non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474447 n.790G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474716 n.1059A>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474719 n.1062G>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474962 n.1305T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475006 n.1349A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1476256 n.2599A>C non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476757 n.3100T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
inhA 1673580 c.-622T>C upstream_gene_variant 0.19 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>C upstream_gene_variant 0.24 ethionamide
isoniazid
inhA 1673595 c.-607A>C upstream_gene_variant 0.25 ethionamide
isoniazid
fabG1 1673596 p.Lys53Glu missense_variant 0.25 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.35 ethionamide
isoniazid
inhA 1673616 c.-586A>G upstream_gene_variant 0.36 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.41 ethionamide
isoniazid
inhA 1673643 c.-559C>A upstream_gene_variant 0.42 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.39 ethionamide
isoniazid
fabG1 1673659 p.Ala74Gln missense_variant 0.39 ethionamide
isoniazid
inhA 1673664 c.-538A>G upstream_gene_variant 0.39 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.38 ethionamide
isoniazid
inhA 1673682 c.-520G>A upstream_gene_variant 0.4 ethionamide
isoniazid
inhA 1673712 c.-490A>G upstream_gene_variant 0.38 ethionamide
isoniazid
inhA 1673713 c.-489T>G upstream_gene_variant 0.38 ethionamide
isoniazid Uncertain significance
inhA 1673724 c.-478A>G upstream_gene_variant 0.4 ethionamide
isoniazid
inhA 1673730 c.-472C>G upstream_gene_variant 0.39 ethionamide
isoniazid
inhA 1673742 c.-460C>T upstream_gene_variant 0.38 ethionamide
isoniazid Uncertain significance
inhA 1673748 c.-454A>G upstream_gene_variant 0.38 ethionamide
isoniazid
inhA 1673757 c.-445G>A upstream_gene_variant 0.4 ethionamide
isoniazid
fabG1 1673767 p.Asn110Asp missense_variant 0.43 ethionamide
isoniazid
inhA 1673784 c.-418G>A upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1673808 c.-394A>G upstream_gene_variant 0.48 ethionamide
isoniazid
inhA 1673811 c.-391G>A upstream_gene_variant 0.47 ethionamide
isoniazid
inhA 1673814 c.-388C>G upstream_gene_variant 0.48 ethionamide
isoniazid
inhA 1673826 c.-376C>A upstream_gene_variant 0.47 ethionamide
isoniazid
fabG1 1673830 p.Lys131Arg missense_variant 0.45 ethionamide
isoniazid
inhA 1673838 c.-364T>C upstream_gene_variant 0.44 ethionamide
isoniazid
inhA 1673841 c.-361A>G upstream_gene_variant 0.45 ethionamide
isoniazid
inhA 1673847 c.-355A>C upstream_gene_variant 0.46 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.47 ethionamide
isoniazid
inhA 1673916 c.-286A>T upstream_gene_variant 0.44 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1673946 c.-256C>G upstream_gene_variant 0.38 ethionamide
isoniazid
fabG1 1673950 p.Leu171Met missense_variant 0.35 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.35 ethionamide
isoniazid
inhA 1673991 c.-211C>T upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1674003 c.-199C>G upstream_gene_variant 0.32 ethionamide
isoniazid
inhA 1674033 c.-169T>C upstream_gene_variant 0.26 ethionamide
isoniazid
fabG1 1674037 p.Gln200Glu missense_variant 0.25 ethionamide
isoniazid
inhA 1674045 c.-157G>A upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1674378 c.177G>A synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674387 c.186A>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674471 c.270G>T synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674474 c.273G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674477 c.276G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674519 c.318C>T synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674522 c.321G>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674542 p.Ala114Asp missense_variant 0.43 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674549 c.348G>T synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674570 c.369G>C synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674573 c.372G>C synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.52 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.59 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.6 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.52 ethionamide
isoniazid
inhA 1674702 c.501G>A synonymous_variant 0.54 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.54 ethionamide
isoniazid
inhA 1674714 c.513C>A synonymous_variant 0.54 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674726 c.525G>A synonymous_variant 0.55 ethionamide
isoniazid
inhA 1674729 c.528G>C synonymous_variant 0.56 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.54 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674777 c.576C>G synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674799 p.Ser200Ala missense_variant 0.51 ethionamide
isoniazid
inhA 1674834 c.633C>G synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674846 c.645C>A synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674858 c.657G>A synonymous_variant 0.5 ethionamide
isoniazid
inhA 1674861 c.660G>A synonymous_variant 0.51 ethionamide
isoniazid
inhA 1674883 p.Ile228Val missense_variant 0.5 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674888 c.687C>T synonymous_variant 0.47 ethionamide
isoniazid
inhA 1674894 c.693C>T synonymous_variant 0.47 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.45 ethionamide
isoniazid
inhA 1674904 c.703_705delGCGinsCC frameshift_variant&missense_variant 0.44 ethionamide
isoniazid
inhA 1674909 c.708G>C synonymous_variant 0.46 ethionamide
isoniazid
inhA 1674939 c.738G>C synonymous_variant 0.52 ethionamide
isoniazid
inhA 1674942 c.741T>C synonymous_variant 0.53 ethionamide
isoniazid
inhA 1674957 c.756G>C synonymous_variant 0.51 ethionamide
isoniazid
inhA 1674960 c.759C>T synonymous_variant 0.51 ethionamide
isoniazid
inhA 1674963 c.762G>T synonymous_variant 0.52 ethionamide
isoniazid
inhA 1674977 p.Tyr259Phe missense_variant 0.55 ethionamide
isoniazid
rpsA 1833256 c.-286C>G upstream_gene_variant 0.42 pyrazinamide
rpsA 1833265 c.-277A>G upstream_gene_variant 0.42 pyrazinamide
rpsA 1833268 c.-274C>G upstream_gene_variant 0.41 pyrazinamide
rpsA 1833277 c.-265C>G upstream_gene_variant 0.39 pyrazinamide
rpsA 1833283 c.-259C>G upstream_gene_variant 0.38 pyrazinamide
rpsA 1833316 c.-226G>A upstream_gene_variant 0.28 pyrazinamide
rpsA 1833319 c.-223C>G upstream_gene_variant 0.28 pyrazinamide
rpsA 1833320 c.-222G>C upstream_gene_variant 0.29 pyrazinamide
rpsA 1833337 c.-205G>C upstream_gene_variant 0.21 pyrazinamide
rpsA 1833568 c.27G>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1833595 c.54T>C synonymous_variant 0.38 pyrazinamide
rpsA 1833613 c.72C>A synonymous_variant 0.37 pyrazinamide
rpsA 1833715 c.174G>A synonymous_variant 0.39 pyrazinamide
rpsA 1833718 c.177C>T synonymous_variant 0.38 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.39 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833754 c.213G>A synonymous_variant 0.37 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1833784 c.243C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.28 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.29 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833847 c.306C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833868 c.327C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.44 pyrazinamide
rpsA 1833988 c.447C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834009 c.468C>G synonymous_variant 0.45 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834033 c.492C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.31 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834108 c.567C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.29 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834183 c.642T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834207 c.666C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834213 c.672G>A synonymous_variant 0.32 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834234 c.693G>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834249 c.708T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834259 c.718_720delCTAinsTG frameshift_variant&stop_gained 0.28 pyrazinamide Uncertain significance
rpsA 1834264 c.723G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834309 c.768C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834348 c.807T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.3 pyrazinamide
rpsA 1834390 c.849G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.32 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834450 c.909G>A synonymous_variant 0.32 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834459 c.918G>A synonymous_variant 0.33 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834474 c.933C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.36 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.39 pyrazinamide
rpsA 1834499 c.958C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834615 c.1074C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834657 c.1116G>A synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834708 c.1167C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.41 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.4 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.39 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.4 pyrazinamide
rpsA 1834766 p.Lys409Ala missense_variant 0.4 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834829 p.Ala430Thr missense_variant 0.25 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.2 linezolid
tsnR 1853372 c.-234A>G upstream_gene_variant 0.2 linezolid
tsnR 1853393 c.-213C>G upstream_gene_variant 0.21 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.21 linezolid
tsnR 1853417 c.-189G>A upstream_gene_variant 0.23 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.23 linezolid
tsnR 1853429 c.-177G>T upstream_gene_variant 0.22 linezolid
tsnR 1853444 c.-162C>T upstream_gene_variant 0.25 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.29 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.24 linezolid
tsnR 1853465 c.-141C>T upstream_gene_variant 0.24 linezolid
tsnR 1853474 c.-132C>T upstream_gene_variant 0.24 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.22 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 0.99 capreomycin Not assoc w R
bacA 2064084 c.645T>A synonymous_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064096 c.633C>T synonymous_variant 0.25 streptomycin
kanamycin
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
bacA 2064099 c.630G>T synonymous_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064110 p.Ser207Ala missense_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
bacA 2064114 p.Ala205Gln missense_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064126 c.603C>T synonymous_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064132 p.Ala199Ser missense_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064141 c.588C>T synonymous_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064150 c.579T>C synonymous_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064165 c.564T>C synonymous_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064210 c.519A>G synonymous_variant 0.47 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064240 c.489A>G synonymous_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064243 c.486A>C synonymous_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064246 c.481_483delCTCinsTG frameshift_variant&synonymous_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
bacA 2064253 p.His159Gly missense_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064258 c.471A>G synonymous_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064264 c.465C>A synonymous_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064269 c.460A>C synonymous_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064276 c.451_453delATCinsGG frameshift_variant&missense_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
bacA 2064279 c.450C>T synonymous_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064306 c.423C>G synonymous_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064312 c.417C>G synonymous_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064315 c.414G>C synonymous_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064318 c.409_411delACCinsGG frameshift_variant&missense_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
bacA 2064339 c.388_390delGTGinsAC frameshift_variant&missense_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
bacA 2064348 c.381T>G synonymous_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064357 c.372G>C synonymous_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064369 c.360A>T synonymous_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064372 c.357A>C synonymous_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064375 c.354G>A synonymous_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064393 c.334_336delACGinsGT frameshift_variant&missense_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
bacA 2064397 p.Gly111Asp missense_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064405 c.324T>C synonymous_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064417 c.312G>A synonymous_variant 0.3 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
bacA 2064426 c.303G>A synonymous_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064435 c.294C>T synonymous_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064456 c.273A>G synonymous_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064459 c.270C>T synonymous_variant 0.29 streptomycin
kanamycin Not assoc w R - Interim
capreomycin
amikacin Not assoc w R - Interim
bacA 2064468 c.261A>G synonymous_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064486 c.243A>G synonymous_variant 0.22 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ndh 2101753 c.1290C>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101765 c.1278C>A synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2101768 c.1275C>G synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2101771 c.1272T>C synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2101774 c.1269T>C synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2101777 c.1266C>G synonymous_variant 0.27 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2101783 c.1260T>C synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2101795 c.1248G>C synonymous_variant 0.34 ethionamide
delamanid
isoniazid
ndh 2101804 c.1239T>G synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2101822 c.1221C>T synonymous_variant 0.38 ethionamide
delamanid
isoniazid
ndh 2101838 p.Ala402Val missense_variant 0.4 ethionamide Uncertain significance
delamanid
isoniazid Uncertain significance
ndh 2101848 c.1195C>T synonymous_variant 0.41 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101852 c.1191G>T synonymous_variant 0.4 ethionamide
delamanid
isoniazid
ndh 2101888 c.1153_1155delGTTinsCC frameshift_variant&missense_variant 0.32 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2101891 c.1152C>G synonymous_variant 0.29 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101894 c.1149T>G synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2101897 c.1146C>T synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2101906 c.1137G>A synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2101915 c.1128T>C synonymous_variant 0.3 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101930 c.1113C>T synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2101939 c.1104A>T synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102787 c.256T>C synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102790 c.253C>T synonymous_variant 0.26 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102800 c.243T>C synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2102806 c.237G>A synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102812 c.231T>C synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102824 c.219G>C synonymous_variant 0.38 ethionamide
delamanid
isoniazid
ndh 2102830 c.213G>T synonymous_variant 0.36 ethionamide
delamanid
isoniazid
ndh 2102836 c.207T>A synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102842 c.201A>G synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102845 c.198A>C synonymous_variant 0.35 ethionamide
delamanid
isoniazid
ndh 2102854 c.189C>T synonymous_variant 0.39 ethionamide
delamanid
isoniazid
ndh 2102857 c.186T>C synonymous_variant 0.4 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102866 c.177C>G synonymous_variant 0.39 ethionamide
delamanid
isoniazid
ndh 2102872 c.171A>G synonymous_variant 0.39 ethionamide
delamanid
isoniazid
ndh 2102883 c.160C>T synonymous_variant 0.36 ethionamide
delamanid
isoniazid
ndh 2102902 c.141C>T synonymous_variant 0.39 ethionamide
delamanid
isoniazid
ndh 2102929 c.114T>C synonymous_variant 0.41 ethionamide
delamanid
isoniazid
ndh 2102938 c.105G>C synonymous_variant 0.39 ethionamide
delamanid
isoniazid
ndh 2102959 c.84C>T synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102962 c.81A>C synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102965 c.78G>A synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102977 c.66T>A synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102980 c.63A>G synonymous_variant 0.3 ethionamide
delamanid
isoniazid
ndh 2102989 c.54G>C synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2103003 c.40A>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155572 c.540G>C synonymous_variant 0.2 isoniazid
katG 2155581 c.531C>G synonymous_variant 0.21 isoniazid
katG 2155590 c.522A>G synonymous_variant 0.21 isoniazid
katG 2155596 c.516G>T synonymous_variant 0.21 isoniazid
katG 2155601 p.Cys171Gly missense_variant 0.2 isoniazid Uncertain significance
katG 2155614 c.498T>C synonymous_variant 0.21 isoniazid
katG 2155617 c.495T>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
katG 2155632 c.480A>C synonymous_variant 0.26 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.26 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.29 isoniazid Uncertain significance
katG 2155670 c.442C>T synonymous_variant 0.33 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.33 isoniazid
katG 2155695 c.417C>A synonymous_variant 0.34 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.32 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.28 isoniazid
katG 2155725 c.387C>T synonymous_variant 0.27 isoniazid
katG 2155737 c.375C>T synonymous_variant 0.25 isoniazid
katG 2155740 p.Gly124Glu missense_variant 0.25 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.25 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.25 isoniazid
katG 2155761 c.351C>T synonymous_variant 0.26 isoniazid
katG 2155767 c.345C>T synonymous_variant 0.25 isoniazid
katG 2155785 c.327T>C synonymous_variant 0.21 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
pncA 2289913 c.-672T>C upstream_gene_variant 0.2 pyrazinamide
pncA 2289916 c.-675A>G upstream_gene_variant 0.21 pyrazinamide
pncA 2289925 c.-684T>C upstream_gene_variant 0.2 pyrazinamide
pncA 2289961 c.-720C>G upstream_gene_variant 0.2 pyrazinamide
pncA 2289978 c.-737T>G upstream_gene_variant 0.21 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.2 pyrazinamide
kasA 2517962 c.-153C>T upstream_gene_variant 0.28 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.24 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.39 isoniazid
kasA 2518252 c.138C>T synonymous_variant 0.4 isoniazid
kasA 2518255 c.141A>G synonymous_variant 0.4 isoniazid
kasA 2518279 c.165T>C synonymous_variant 0.39 isoniazid
kasA 2518282 c.168A>G synonymous_variant 0.39 isoniazid
kasA 2518283 c.169_171delGCGinsCC frameshift_variant&missense_variant 0.38 isoniazid
kasA 2518297 c.183C>T synonymous_variant 0.39 isoniazid
kasA 2518300 c.186T>C synonymous_variant 0.4 isoniazid
kasA 2518306 c.192C>G synonymous_variant 0.39 isoniazid
kasA 2518312 p.Asp66Glu missense_variant 0.37 isoniazid
kasA 2518321 c.207C>T synonymous_variant 0.34 isoniazid
kasA 2518323 p.Ser70Asn missense_variant 0.33 isoniazid
kasA 2518336 c.222A>G synonymous_variant 0.29 isoniazid
kasA 2518339 c.225C>G synonymous_variant 0.28 isoniazid
kasA 2518357 c.243G>C synonymous_variant 0.22 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.24 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.24 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.24 isoniazid
kasA 2518582 c.468G>C synonymous_variant 0.24 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.24 isoniazid
kasA 2518597 c.483C>T synonymous_variant 0.24 isoniazid
kasA 2518603 c.489G>A synonymous_variant 0.24 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.23 isoniazid
kasA 2518648 c.534C>T synonymous_variant 0.23 isoniazid
kasA 2518651 c.537C>G synonymous_variant 0.23 isoniazid
kasA 2518663 c.549T>G synonymous_variant 0.23 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.19 isoniazid
kasA 2519203 c.1089C>G synonymous_variant 0.29 isoniazid
kasA 2519218 c.1104G>C synonymous_variant 0.29 isoniazid
kasA 2519230 c.1116C>T synonymous_variant 0.28 isoniazid
kasA 2519234 c.1120_1122delGAGinsCA frameshift_variant&missense_variant 0.28 isoniazid
kasA 2519239 c.1125A>C synonymous_variant 0.28 isoniazid
kasA 2519242 c.1128C>T synonymous_variant 0.29 isoniazid
kasA 2519255 p.Asp381Asn missense_variant 0.27 isoniazid
kasA 2519263 c.1149C>T synonymous_variant 0.28 isoniazid
kasA 2519266 c.1152C>T synonymous_variant 0.27 isoniazid
kasA 2519272 c.1158C>G synonymous_variant 0.27 isoniazid
kasA 2519281 c.1167G>T synonymous_variant 0.25 isoniazid
kasA 2519287 c.1173T>C synonymous_variant 0.25 isoniazid
kasA 2519295 p.Tyr394Phe missense_variant 0.24 isoniazid
kasA 2519299 c.1185C>T synonymous_variant 0.23 isoniazid
kasA 2519305 c.1191A>G synonymous_variant 0.23 isoniazid
kasA 2519306 p.Val398Ile missense_variant 0.22 isoniazid
eis 2715432 c.-100C>T upstream_gene_variant 1.0 amikacin
kanamycin
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
folC 2747202 p.Leu133Met missense_variant 0.2 para-aminosalicylic_acid
folC 2747205 p.Ala132Pro missense_variant 0.2 para-aminosalicylic_acid
folC 2747209 p.Leu130Phe missense_variant 0.21 para-aminosalicylic_acid
folC 2747224 c.375G>C synonymous_variant 0.28 para-aminosalicylic_acid
folC 2747230 c.369C>A synonymous_variant 0.3 para-aminosalicylic_acid
folC 2747239 c.360T>C synonymous_variant 0.34 para-aminosalicylic_acid
folC 2747248 c.351G>C synonymous_variant 0.37 para-aminosalicylic_acid
folC 2747260 c.339G>A synonymous_variant 0.38 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.41 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.4 para-aminosalicylic_acid
folC 2747302 c.297A>C synonymous_variant 0.41 para-aminosalicylic_acid
folC 2747317 c.282C>A synonymous_variant 0.41 para-aminosalicylic_acid
folC 2747327 p.Arg91Gln missense_variant 0.42 para-aminosalicylic_acid
folC 2747335 c.264G>C synonymous_variant 0.38 para-aminosalicylic_acid
folC 2747341 c.258C>G synonymous_variant 0.36 para-aminosalicylic_acid
folC 2747346 c.253C>T synonymous_variant 0.34 para-aminosalicylic_acid
folC 2747347 c.252G>A synonymous_variant 0.34 para-aminosalicylic_acid
folC 2747359 c.240C>A synonymous_variant 0.33 para-aminosalicylic_acid
folC 2747374 c.225G>A synonymous_variant 0.29 para-aminosalicylic_acid
folC 2747383 c.216C>G synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.21 para-aminosalicylic_acid
Rv2477c 2782498 c.1545C>T synonymous_variant 0.83 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
Rv2477c 2782858 c.1185C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782876 c.1167G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782888 c.1155G>A synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782903 c.1140C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782913 p.Ser377Thr missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782918 c.1125C>T synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782926 c.1116_1117insG frameshift_variant 0.36 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782929 c.1113delG frameshift_variant 0.36 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782948 c.1095A>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>A synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782987 c.1056C>A synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783044 c.999G>A synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783053 c.990C>T synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783074 c.969G>A synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783087 p.Asn319Ser missense_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783107 c.936G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783143 c.900G>A synonymous_variant 0.45 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.47 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.45 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783170 c.873C>T synonymous_variant 0.43 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783173 c.870C>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783197 c.846C>A synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783206 c.837G>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783209 c.834G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783515 c.528C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783533 c.510G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783554 c.489C>T synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783596 c.447C>T synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783617 c.426G>A synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTT frameshift_variant&missense_variant 0.51 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783632 c.411C>G synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.57 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.55 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783704 c.339C>T synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Leu missense_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783785 c.258C>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783791 c.252C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783812 c.231G>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783837 p.Thr69Ser missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783847 p.Thr66Ala missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783848 c.195C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783853 c.190C>T synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783857 c.186C>T synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783869 c.174C>T synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783874 p.Pro57Ala missense_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783923 c.120C>T synonymous_variant 0.56 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783926 c.117C>G synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783956 p.Tyr29Phe missense_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.5 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784501 c.-459T>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784525 c.-483G>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784551 c.-509G>A upstream_gene_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859305 c.1114C>T synonymous_variant 0.29 clofazimine
bedaquiline
pepQ 2859306 c.1113T>C synonymous_variant 0.29 clofazimine
bedaquiline
pepQ 2859318 c.1101A>G synonymous_variant 0.33 clofazimine
bedaquiline
pepQ 2859321 c.1098C>T synonymous_variant 0.34 clofazimine
bedaquiline
pepQ 2859349 p.Gln357Leu missense_variant 0.43 clofazimine
bedaquiline
pepQ 2859356 p.Ala355Thr missense_variant 0.42 clofazimine
bedaquiline
pepQ 2859367 p.Met351Lys missense_variant 0.41 clofazimine
bedaquiline
pepQ 2859372 c.1047G>A synonymous_variant 0.42 clofazimine
bedaquiline
pepQ 2859386 p.Ala345Pro missense_variant 0.38 clofazimine
bedaquiline
pepQ 2859387 c.1032G>A synonymous_variant 0.38 clofazimine
bedaquiline
pepQ 2859405 c.1014C>T synonymous_variant 0.44 clofazimine
bedaquiline
pepQ 2859408 c.1011C>T synonymous_variant 0.42 clofazimine
bedaquiline
pepQ 2859414 c.1005T>C synonymous_variant 0.46 clofazimine
bedaquiline
pepQ 2859429 c.990A>G synonymous_variant 0.48 clofazimine
bedaquiline
pepQ 2859438 c.981T>C synonymous_variant 0.51 clofazimine
bedaquiline
pepQ 2859468 c.951G>T synonymous_variant 0.47 clofazimine
bedaquiline
pepQ 2859489 p.Val310Ala missense_variant 0.41 clofazimine
bedaquiline
pepQ 2859492 c.927G>A synonymous_variant 0.4 clofazimine
bedaquiline
pepQ 2859504 c.915G>A synonymous_variant 0.4 clofazimine
bedaquiline
pepQ 2859513 c.906A>T synonymous_variant 0.36 clofazimine
bedaquiline
pepQ 2859525 c.894T>C synonymous_variant 0.3 clofazimine
bedaquiline
pepQ 2859528 c.891T>G synonymous_variant 0.3 clofazimine
bedaquiline
pepQ 2859540 c.879A>T synonymous_variant 0.27 clofazimine
bedaquiline
pepQ 2859546 c.873T>C synonymous_variant 0.22 clofazimine
bedaquiline
pepQ 2859555 p.Glu288Asp missense_variant 0.2 clofazimine
bedaquiline
Rv2681 2996278 c.-461T>C upstream_gene_variant 0.21 capreomycin
Rv2681 2996287 c.-452A>C upstream_gene_variant 0.21 capreomycin
Rv2680 2996308 p.Glu68Asp missense_variant 0.29 capreomycin
Rv2680 2996315 p.Val71Ile missense_variant 0.29 capreomycin
Rv2680 2996318 c.214_216delATTinsGC frameshift_variant&missense_variant 0.29 capreomycin Uncertain significance
Rv2681 2996323 c.-416G>C upstream_gene_variant 0.28 capreomycin
Rv2681 2996326 c.-413G>A upstream_gene_variant 0.29 capreomycin
Rv2681 2996329 c.-410T>A upstream_gene_variant 0.32 capreomycin
Rv2681 2996335 c.-404G>A upstream_gene_variant 0.35 capreomycin
Rv2680 2996344 c.240C>A synonymous_variant 0.41 capreomycin Not assoc w R - Interim
Rv2680 2996360 p.Met86Leu missense_variant 0.4 capreomycin
Rv2681 2996368 c.-371T>C upstream_gene_variant 0.4 capreomycin
Rv2681 2996374 c.-365G>C upstream_gene_variant 0.38 capreomycin
Rv2680 2996377 p.Asp91Glu missense_variant 0.38 capreomycin
Rv2681 2996383 c.-356C>G upstream_gene_variant 0.37 capreomycin
Rv2680 2996386 c.282T>C synonymous_variant 0.37 capreomycin Not assoc w R - Interim
Rv2681 2996389 c.-350A>T upstream_gene_variant 0.36 capreomycin
Rv2681 2996401 c.-338T>C upstream_gene_variant 0.38 capreomycin
Rv2681 2996404 c.-335T>C upstream_gene_variant 0.39 capreomycin
Rv2681 2996419 c.-320T>C upstream_gene_variant 0.4 capreomycin
Rv2680 2996441 p.Ser113His missense_variant 0.32 capreomycin
Rv2680 2996446 c.342A>G synonymous_variant 0.31 capreomycin Not assoc w R - Interim
Rv2680 2996450 p.Val116Ile missense_variant 0.31 capreomycin
Rv2681 2996458 c.-281C>G upstream_gene_variant 0.31 capreomycin
Rv2681 2996467 c.-272C>G upstream_gene_variant 0.33 capreomycin
Rv2681 2996476 c.-263A>G upstream_gene_variant 0.33 capreomycin
Rv2681 2996491 c.-248G>C upstream_gene_variant 0.26 capreomycin
Rv2680 2996494 p.Asp130Glu missense_variant 0.25 capreomycin
Rv2680 2996501 p.Thr133Glu missense_variant 0.23 capreomycin
Rv2680 2996523 p.Arg140Thr missense_variant 0.21 capreomycin
Rv2681 2996533 c.-206C>A upstream_gene_variant 0.2 capreomycin
Rv2681 2996539 c.-200T>C upstream_gene_variant 0.22 capreomycin
Rv2681 2996563 c.-176A>C upstream_gene_variant 0.21 capreomycin
Rv2681 2996581 c.-158G>T upstream_gene_variant 0.27 capreomycin
Rv2681 2996590 c.-149C>G upstream_gene_variant 0.29 capreomycin
Rv2681 2996593 c.-146T>C upstream_gene_variant 0.31 capreomycin
Rv2681 2996600 c.-139C>T upstream_gene_variant 0.35 capreomycin
Rv2681 2996605 c.-134G>A upstream_gene_variant 0.36 capreomycin
Rv2681 2996617 c.-122A>G upstream_gene_variant 0.36 capreomycin
Rv2681 2996626 c.-113G>C upstream_gene_variant 0.35 capreomycin
Rv2680 2996639 p.Leu179Val missense_variant 0.32 capreomycin
Rv2680 2996646 p.Ala181Gly missense_variant 0.31 capreomycin
Rv2681 2996650 c.-89T>C upstream_gene_variant 0.32 capreomycin
Rv2680 2996653 c.549C>A synonymous_variant 0.31 capreomycin Not assoc w R - Interim
Rv2680 2996654 p.Gln184Glu missense_variant 0.31 capreomycin Uncertain significance
Rv2681 2996668 c.-71C>T upstream_gene_variant 0.33 capreomycin
Rv2681 2996683 c.-56G>T upstream_gene_variant 0.28 capreomycin
Rv2681 2996686 c.-53C>G upstream_gene_variant 0.28 capreomycin
Rv2681 2996690 c.-49C>T upstream_gene_variant 0.27 capreomycin
Rv2681 2996698 c.-41A>G upstream_gene_variant 0.28 capreomycin
Rv2681 2997189 p.Ala151Thr missense_variant 0.21 capreomycin
Rv2681 2997204 c.466_468delTTAinsCG frameshift_variant&missense_variant 0.2 capreomycin Uncertain significance
Rv2681 2997209 c.471T>G synonymous_variant 0.22 capreomycin Not assoc w R - Interim
Rv2681 2997212 c.474A>C synonymous_variant 0.23 capreomycin Not assoc w R - Interim
Rv2681 2997218 c.480A>G synonymous_variant 0.24 capreomycin
Rv2681 2997222 p.Thr162Ala missense_variant 0.26 capreomycin
Rv2681 2997254 c.516G>A synonymous_variant 0.26 capreomycin
Rv2681 2997257 c.519C>T synonymous_variant 0.26 capreomycin
Rv2681 2997263 c.525A>G synonymous_variant 0.26 capreomycin
Rv2681 2997266 c.528C>G synonymous_variant 0.26 capreomycin
Rv2681 2997278 c.540G>C synonymous_variant 0.25 capreomycin
Rv2681 2997291 c.553T>C synonymous_variant 0.2 capreomycin
Rv2681 2997500 c.762A>G synonymous_variant 0.2 capreomycin
Rv2681 2997509 c.771A>C synonymous_variant 0.23 capreomycin
Rv2681 2997510 p.Ala258Thr missense_variant 0.22 capreomycin
Rv2681 2997521 c.783A>T synonymous_variant 0.25 capreomycin
Rv2681 2997533 c.795C>A synonymous_variant 0.24 capreomycin
Rv2681 2997548 c.810C>T synonymous_variant 0.25 capreomycin
Rv2681 2997551 c.813C>A synonymous_variant 0.25 capreomycin
Rv2681 2997554 c.816G>C synonymous_variant 0.25 capreomycin
Rv2681 2997558 c.820T>C synonymous_variant 0.25 capreomycin
Rv2681 2997575 c.837T>C synonymous_variant 0.25 capreomycin Not assoc w R - Interim
Rv2681 2997581 c.843T>C synonymous_variant 0.26 capreomycin
Rv2681 2997605 c.867A>G synonymous_variant 0.24 capreomycin
Rv2681 2997617 c.879T>G synonymous_variant 0.23 capreomycin
Rv2752c 3064797 c.1395G>C synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064803 c.1389C>T synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064808 c.1384C>T synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064832 p.Ala454Thr missense_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064838 c.1354T>C synonymous_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064848 c.1344C>T synonymous_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064860 c.1332G>C synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064866 c.1326G>T synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064872 c.1320T>G synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064876 c.1315_1316delTCinsAG synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064881 c.1311T>C synonymous_variant 0.22 ethambutol
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3064887 c.1305A>G synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064893 c.1299C>T synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064896 c.1296T>G synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065154 c.1038G>A synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065409 c.783C>T synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065418 c.774A>G synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065421 c.771G>T synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065433 c.759G>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065469 c.723C>T synonymous_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065484 c.708G>A synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065490 c.702A>C synonymous_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065493 c.699G>C synonymous_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065499 c.693A>G synonymous_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065505 c.687C>T synonymous_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065508 c.684T>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065514 c.678C>T synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065517 c.675C>G synonymous_variant 0.37 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065528 c.664C>T synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065532 c.660A>G synonymous_variant 0.35 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065568 p.Ile208His missense_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065580 c.612G>C synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065583 c.609G>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066615 c.-424C>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066618 c.-427A>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066696 c.-505T>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066707 c.-516A>G upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066723 c.-532C>T upstream_gene_variant 0.34 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066744 c.-553C>G upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066747 c.-558_-556delCAAinsTTG upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066756 c.-567_-565delCGGinsTCC upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066769 c.-578A>G upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066771 c.-580C>G upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066780 c.-589C>G upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066783 c.-592G>C upstream_gene_variant 0.33 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066795 c.-604G>C upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066810 c.-619G>A upstream_gene_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.32 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066846 c.-655G>A upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066855 c.-664T>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067631 c.315C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067637 c.309G>A synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067643 c.303C>T synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067667 c.279G>A synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067673 c.273C>T synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067676 c.270C>T synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067679 c.267C>T synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067715 c.229_231delAGCinsGT frameshift_variant&synonymous_variant 0.44 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.43 para-aminosalicylic_acid
thyX 3067727 c.219A>T synonymous_variant 0.42 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.37 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.37 para-aminosalicylic_acid
thyX 3067787 p.Lys53Arg missense_variant 0.27 para-aminosalicylic_acid
thyX 3067790 c.156C>T synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067832 c.114C>T synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067835 c.111G>A synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067841 c.105G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067853 c.93C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067859 c.87C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067886 c.60A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.24 para-aminosalicylic_acid
thyA 3074202 c.270C>A synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.23 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074217 c.255T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074220 c.252A>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074262 c.210T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074268 c.204T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074274 c.198T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074285 c.187T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074286 c.186T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074305 p.Ala56Val missense_variant 0.2 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3623360 c.1551A>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3623363 c.1548T>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3623366 c.1545T>G synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3623380 p.Ala511Thr missense_variant 0.28 bedaquiline
rifampicin
lpqB 3623384 c.1527C>T synonymous_variant 0.27 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3623388 p.Thr508Asn missense_variant 0.26 bedaquiline
rifampicin
lpqB 3623393 c.1518A>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3623411 c.1500T>G synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3623444 c.1467T>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3623480 c.1431C>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3623606 c.1305G>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3623624 c.1287G>C synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3623627 c.1284T>C synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3623636 c.1275C>G synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3623642 c.1269G>A synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3623648 c.1263A>G synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3623653 p.Pro420Thr missense_variant 0.29 bedaquiline
rifampicin
lpqB 3623654 p.Asp419Glu missense_variant 0.29 bedaquiline
rifampicin
lpqB 3623660 c.1251A>T synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3623676 p.Val412Asn missense_variant 0.35 bedaquiline
rifampicin
lpqB 3623720 c.1191C>T synonymous_variant 0.43 bedaquiline
rifampicin
lpqB 3623736 p.Ser392Asn missense_variant 0.42 bedaquiline
rifampicin
lpqB 3623756 c.1155G>C synonymous_variant 0.37 bedaquiline
rifampicin
lpqB 3623768 c.1143C>T synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3623774 c.1137C>T synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3623782 p.Val377Ile missense_variant 0.25 bedaquiline
rifampicin
lpqB 3623788 c.1123T>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3623789 c.1122T>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3623799 p.Glu371Val missense_variant 0.22 bedaquiline
rifampicin
lpqB 3624662 c.249C>T synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624680 c.231T>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624688 p.Glu75Gln missense_variant 0.25 bedaquiline
rifampicin
lpqB 3624695 c.216C>T synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624701 c.210T>C synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3624725 c.186G>C synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.36 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.156A>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624761 c.150G>A synonymous_variant 0.32 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624767 c.144C>T synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624770 c.141T>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624776 c.135T>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624779 c.132G>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624783 p.Ser43Thr missense_variant 0.24 bedaquiline
rifampicin
lpqB 3624788 c.123A>G synonymous_variant 0.23 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624800 c.111G>A synonymous_variant 0.22 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625189 c.1425A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625198 c.-288C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625207 c.-297C>T upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625243 c.-333T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
lpqB 3625255 c.-345T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625273 c.-363C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625276 c.-366C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
lpqB 3625330 c.-420C>A upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625345 c.-435T>C upstream_gene_variant 0.56 bedaquiline
rifampicin
lpqB 3625375 c.-465A>G upstream_gene_variant 0.54 bedaquiline
rifampicin
lpqB 3625381 c.-471T>C upstream_gene_variant 0.54 bedaquiline
rifampicin
lpqB 3625396 c.-486G>C upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3625407 p.Gln403Glu missense_variant 0.56 bedaquiline
rifampicin
lpqB 3625411 c.-501C>G upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrB 3625419 p.Leu399Met missense_variant 0.58 bedaquiline
rifampicin
lpqB 3625420 c.-510T>C upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3625441 c.1171_1173delGCCinsAG frameshift_variant&missense_variant 0.6 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625465 c.-555T>C upstream_gene_variant 0.59 bedaquiline
rifampicin
lpqB 3625471 c.-561C>G upstream_gene_variant 0.59 bedaquiline
rifampicin
lpqB 3625474 c.-564G>T upstream_gene_variant 0.58 bedaquiline
rifampicin
lpqB 3625486 c.-576G>C upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3625489 c.1123_1125delACAinsGG frameshift_variant&missense_variant 0.57 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625497 c.1117T>C synonymous_variant 0.59 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625510 c.-600T>C upstream_gene_variant 0.6 bedaquiline
rifampicin
lpqB 3625513 c.-603G>C upstream_gene_variant 0.6 bedaquiline
rifampicin
lpqB 3625528 c.-618G>C upstream_gene_variant 0.59 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.57 bedaquiline
rifampicin
lpqB 3625540 c.-630G>C upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625570 c.-660G>A upstream_gene_variant 0.53 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.56 bedaquiline
rifampicin
lpqB 3625606 c.-696C>G upstream_gene_variant 0.56 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.54 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.56 bedaquiline
rifampicin
lpqB 3625663 c.-753G>C upstream_gene_variant 0.56 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625714 c.-804C>T upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625744 c.870G>A synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625753 c.859_861delGCCinsAT frameshift_variant&missense_variant 0.49 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625795 c.-885G>C upstream_gene_variant 0.44 bedaquiline
rifampicin
lpqB 3625801 c.-891G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625807 c.-897C>T upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625819 c.795G>A synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625822 c.-912C>T upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625828 c.-918G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625840 c.-930A>G upstream_gene_variant 0.39 bedaquiline
rifampicin
lpqB 3625846 c.-936G>T upstream_gene_variant 0.36 bedaquiline
rifampicin
lpqB 3625849 c.-939T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625852 c.-942A>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625864 c.-954T>A upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625879 c.-969G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625891 c.723G>T synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626008 p.Ala202Val missense_variant 0.21 bedaquiline
rifampicin Uncertain significance
mtrB 3626023 c.591G>C synonymous_variant 0.22 bedaquiline
rifampicin
mtrB 3626029 c.585A>G synonymous_variant 0.24 bedaquiline
rifampicin
mtrB 3626038 c.576C>T synonymous_variant 0.29 bedaquiline
rifampicin
mtrB 3626050 c.564G>C synonymous_variant 0.33 bedaquiline
rifampicin
mtrB 3626054 p.Leu187Ser missense_variant 0.35 bedaquiline
rifampicin
mtrB 3626062 c.552T>C synonymous_variant 0.37 bedaquiline
rifampicin
mtrB 3626065 c.549G>T synonymous_variant 0.38 bedaquiline
rifampicin
mtrB 3626070 p.Ile182Val missense_variant 0.4 bedaquiline
rifampicin
mtrB 3626077 c.537C>G synonymous_variant 0.4 bedaquiline
rifampicin
mtrB 3626086 c.528C>G synonymous_variant 0.44 bedaquiline
rifampicin
mtrB 3626095 p.Glu173Asp missense_variant 0.45 bedaquiline
rifampicin
mtrB 3626101 p.Gln171His missense_variant 0.44 bedaquiline
rifampicin
mtrB 3626107 c.507G>C synonymous_variant 0.43 bedaquiline
rifampicin
mtrB 3626122 c.492C>G synonymous_variant 0.41 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626125 c.489C>G synonymous_variant 0.41 bedaquiline
rifampicin
mtrB 3626149 c.465C>G synonymous_variant 0.45 bedaquiline
rifampicin
mtrB 3626154 c.460C>T synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626158 p.Asn152Ser missense_variant 0.45 bedaquiline
rifampicin
mtrB 3626161 c.453C>T synonymous_variant 0.45 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626170 c.444T>C synonymous_variant 0.46 bedaquiline
rifampicin
mtrB 3626186 p.Thr143Ser missense_variant 0.48 bedaquiline
rifampicin
mtrB 3626194 c.420T>A synonymous_variant 0.46 bedaquiline
rifampicin
mtrB 3626206 c.408T>C synonymous_variant 0.47 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626209 c.405T>G synonymous_variant 0.46 bedaquiline
rifampicin
mtrB 3626230 c.384T>C synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626237 p.Ala126Val missense_variant 0.44 bedaquiline
rifampicin
mtrB 3626245 c.367_369delCTCinsTG frameshift_variant&synonymous_variant 0.42 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626251 c.363T>C synonymous_variant 0.43 bedaquiline
rifampicin
mtrB 3626254 c.360G>C synonymous_variant 0.44 bedaquiline
rifampicin
mtrB 3626260 c.354T>C synonymous_variant 0.44 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626263 c.351C>G synonymous_variant 0.45 bedaquiline
rifampicin
mtrB 3626271 p.Thr115Ser missense_variant 0.47 bedaquiline
rifampicin
mtrB 3626293 c.321G>A synonymous_variant 0.49 bedaquiline
rifampicin
mtrB 3626296 c.318T>C synonymous_variant 0.5 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626302 c.312G>C synonymous_variant 0.52 bedaquiline
rifampicin
mtrB 3626314 c.300G>C synonymous_variant 0.51 bedaquiline
rifampicin
mtrB 3626317 c.297A>G synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626332 c.282T>C synonymous_variant 0.55 bedaquiline
rifampicin
mtrB 3626341 c.273C>A synonymous_variant 0.56 bedaquiline
rifampicin
mtrB 3626347 c.267C>T synonymous_variant 0.56 bedaquiline
rifampicin
mtrB 3626386 c.228G>C synonymous_variant 0.57 bedaquiline
rifampicin
mtrB 3626390 p.Arg75Lys missense_variant 0.57 bedaquiline
rifampicin
mtrB 3626407 c.207C>G synonymous_variant 0.57 bedaquiline
rifampicin
mtrB 3626410 c.204T>G synonymous_variant 0.56 bedaquiline
rifampicin
mtrB 3626413 c.201T>C synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626443 c.171T>C synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626455 c.159C>G synonymous_variant 0.46 bedaquiline
rifampicin
mtrB 3626461 c.153A>C synonymous_variant 0.43 bedaquiline
rifampicin
mtrB 3626467 c.147G>C synonymous_variant 0.4 bedaquiline
rifampicin
mtrB 3626473 c.141T>C synonymous_variant 0.37 bedaquiline
rifampicin
mtrB 3626476 c.138C>G synonymous_variant 0.35 bedaquiline
rifampicin
mtrB 3626481 c.133C>T synonymous_variant 0.33 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626496 c.118C>T synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626684 c.-71G>A upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3626708 c.642G>A synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626711 c.-98T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626753 c.-140G>A upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.47 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>A upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.52 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626843 c.-230G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626876 c.-263A>G upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrA 3626882 c.468G>C synonymous_variant 0.53 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626891 c.-278G>A upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrA 3626906 c.444C>T synonymous_variant 0.56 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626912 c.438T>C synonymous_variant 0.59 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>G upstream_gene_variant 0.65 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.66 bedaquiline
rifampicin
mtrB 3626942 c.-329A>C upstream_gene_variant 0.66 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.69 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrB 3626996 c.-383G>A upstream_gene_variant 0.72 bedaquiline
rifampicin
mtrB 3627011 c.-398T>C upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrA 3627026 c.324G>A synonymous_variant 0.67 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3627035 c.-422G>A upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3627059 c.-446G>C upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrB 3627068 c.-455T>A upstream_gene_variant 0.62 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.59 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 0.58 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627101 c.-488C>G upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3627104 c.-491C>G upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3627116 c.-503G>A upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3627122 c.-509T>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrA 3627175 c.175C>T synonymous_variant 0.6 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.59 bedaquiline
rifampicin
mtrB 3627197 c.-584T>C upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrA 3627224 c.126G>A synonymous_variant 0.57 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.57 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627230 c.-617G>A upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.57 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrA 3627277 c.73C>T synonymous_variant 0.57 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627296 c.-683T>C upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3627301 c.-688T>C upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.52 bedaquiline
rifampicin
mtrA 3627342 p.Thr3Ser missense_variant 0.46 bedaquiline
rifampicin
mtrB 3627360 c.-747G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627361 c.-748T>A upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627368 c.-755G>A upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3627377 c.-764G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627380 c.-767T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627401 c.-788A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
fbiA 3640220 c.-323A>G upstream_gene_variant 0.21 clofazimine
pretomanid
delamanid
fbiA 3640232 c.-311T>C upstream_gene_variant 0.28 clofazimine
pretomanid
delamanid
fbiA 3640261 c.-281delG upstream_gene_variant 0.33 clofazimine
pretomanid
delamanid
fbiA 3640347 c.-196A>G upstream_gene_variant 0.27 clofazimine
pretomanid
delamanid
fbiA 3640365 c.-178C>G upstream_gene_variant 0.2 clofazimine
pretomanid
delamanid
fbiA 3640785 p.Gln81His missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiB 3640797 c.-738T>G upstream_gene_variant 0.26 clofazimine
pretomanid
delamanid
fbiA 3640808 p.Met89Lys missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiA 3640810 p.Gln90Glu missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3640818 c.-717G>C upstream_gene_variant 0.29 clofazimine
pretomanid
delamanid
fbiA 3640820 p.Val93Ala missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3640827 c.-708T>C upstream_gene_variant 0.31 clofazimine
pretomanid
delamanid
fbiA 3640831 p.Val97Met missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiB 3640842 c.-693C>T upstream_gene_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3640848 c.-687C>T upstream_gene_variant 0.26 clofazimine
pretomanid
delamanid
fbiA 3640849 p.Glu103Gln missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiB 3640857 c.-678G>C upstream_gene_variant 0.25 clofazimine
pretomanid
delamanid
fbiB 3640863 c.-672C>A upstream_gene_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3641993 c.459A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642638 c.1104C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3642662 c.1128C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3642665 c.1131C>A synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3642668 c.1134A>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3642671 c.1137G>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiB 3642716 c.1182C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiB 3642731 c.1197C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3642764 p.Asp410Glu missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiB 3642779 c.1245A>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiB 3642785 p.Asp417Glu missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiB 3642815 c.1281A>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiB 3642818 c.1284T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642821 c.1287C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642827 p.Glu431Asp missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642831 p.Ser433Ala missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642851 c.1317G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642854 c.1320T>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642855 p.Ala441Leu missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642860 c.1326C>T synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642863 c.1329T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
rpoA 3877467 c.1041T>C synonymous_variant 0.44 rifampicin
rpoA 3877494 p.Glu338Asp missense_variant 0.48 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.47 rifampicin
rpoA 3877506 c.1002C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877515 c.993G>C synonymous_variant 0.49 rifampicin
rpoA 3877524 c.984C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877542 c.966C>T synonymous_variant 0.49 rifampicin
rpoA 3877548 c.960C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877557 c.951C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877569 c.939G>C synonymous_variant 0.48 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.55 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.45 rifampicin
rpoA 3877665 c.843C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.44 rifampicin
rpoA 3877671 c.837C>T synonymous_variant 0.45 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.47 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877698 c.810C>T synonymous_variant 0.45 rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>C synonymous_variant 0.4 rifampicin
rpoA 3877763 c.745C>T synonymous_variant 0.32 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877767 c.741C>T synonymous_variant 0.33 rifampicin
rpoA 3877770 c.738A>C synonymous_variant 0.32 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877803 c.705G>C synonymous_variant 0.39 rifampicin
rpoA 3877815 c.693C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877824 c.684G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.46 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.48 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>A synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877896 c.612G>C synonymous_variant 0.48 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.49 rifampicin
rpoA 3877905 c.603A>C synonymous_variant 0.49 rifampicin
rpoA 3877909 p.Asn200Ser missense_variant 0.51 rifampicin
rpoA 3877926 c.582G>C synonymous_variant 0.56 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3877983 c.525C>G synonymous_variant 0.55 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.55 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.49 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.48 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.48 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.49 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3878052 c.456C>T synonymous_variant 0.48 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.49 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.47 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.42 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.43 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.44 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.42 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.43 rifampicin
rpoA 3878126 c.382C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878130 c.378C>G synonymous_variant 0.41 rifampicin
rpoA 3878145 c.363C>T synonymous_variant 0.39 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>G synonymous_variant 0.43 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.42 rifampicin
rpoA 3878205 c.303T>A synonymous_variant 0.43 rifampicin
rpoA 3878208 c.300G>A synonymous_variant 0.43 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878229 c.279C>G synonymous_variant 0.51 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.47 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.47 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.47 rifampicin
rpoA 3878262 c.244_246delAGCinsGT frameshift_variant&synonymous_variant 0.46 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.47 rifampicin Uncertain significance
rpoA 3878316 c.192C>G synonymous_variant 0.44 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.41 rifampicin
rpoA 3878358 c.150C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878364 c.144A>C synonymous_variant 0.37 rifampicin
rpoA 3878384 c.124C>T synonymous_variant 0.27 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.27 rifampicin
rpoA 3878394 c.114G>T synonymous_variant 0.24 rifampicin
rpoA 3878725 c.-220_-218delCTAinsTG upstream_gene_variant 0.22 rifampicin
rpoA 3878739 c.-232C>T upstream_gene_variant 0.22 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.22 rifampicin
rpoA 3878749 c.-242G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878755 c.-248G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878779 c.-272C>T upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878788 c.-281G>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878791 c.-284C>T upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.34 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.36 rifampicin
rpoA 3878812 c.-305G>A upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878830 c.-323G>C upstream_gene_variant 0.41 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.42 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.45 rifampicin
rpoA 3878869 c.-362G>T upstream_gene_variant 0.42 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.42 rifampicin Uncertain significance
rpoA 3878893 c.-386C>T upstream_gene_variant 0.42 rifampicin
rpoA 3878896 c.-389G>A upstream_gene_variant 0.42 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.45 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.44 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.43 rifampicin Uncertain significance
rpoA 3878929 c.-422G>C upstream_gene_variant 0.41 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.4 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878962 c.-455G>C upstream_gene_variant 0.37 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.36 rifampicin
rpoA 3878995 c.-488A>G upstream_gene_variant 0.33 rifampicin
rpoA 3878998 c.-493_-491delCTCinsTG upstream_gene_variant 0.33 rifampicin
rpoA 3879001 c.-494C>T upstream_gene_variant 0.33 rifampicin
rpoA 3879005 c.-498A>G upstream_gene_variant 0.34 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.37 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.39 rifampicin
rpoA 3879067 c.-560G>A upstream_gene_variant 0.52 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.52 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.54 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.54 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.51 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.49 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.47 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.45 rifampicin
rpoA 3879184 c.-677G>A upstream_gene_variant 0.39 rifampicin
rpoA 3879226 c.-719G>A upstream_gene_variant 0.35 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.36 rifampicin
ddn 3986622 c.-222C>T upstream_gene_variant 0.33 delamanid
pretomanid
ddn 3986636 c.-208C>A upstream_gene_variant 0.29 delamanid
pretomanid
ddn 3986637 c.-207C>T upstream_gene_variant 0.29 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.26 delamanid
pretomanid
ddn 3986651 c.-193G>A upstream_gene_variant 0.25 delamanid
pretomanid
ddn 3986658 c.-186G>A upstream_gene_variant 0.24 delamanid
pretomanid
ddn 3986663 c.-181G>A upstream_gene_variant 0.23 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.22 delamanid
pretomanid
clpC1 4038278 c.2427T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAC frameshift_variant&missense_variant 0.29 pyrazinamide
clpC1 4038314 c.2391T>A synonymous_variant 0.29 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038386 c.2317_2319delTTGinsCA frameshift_variant&missense_variant 0.32 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.32 pyrazinamide
clpC1 4038395 c.2310C>A synonymous_variant 0.33 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.33 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038410 c.2295C>T synonymous_variant 0.37 pyrazinamide
clpC1 4038436 p.Ala757Ser missense_variant 0.41 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.4 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038454 p.Leu751Met missense_variant 0.41 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.41 pyrazinamide
clpC1 4038461 c.2244G>T synonymous_variant 0.43 pyrazinamide
clpC1 4038470 c.2235G>A synonymous_variant 0.44 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.51 pyrazinamide
clpC1 4038530 c.2175G>A synonymous_variant 0.52 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038587 c.2118C>A synonymous_variant 0.58 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.59 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.58 pyrazinamide
clpC1 4038605 c.2100G>A synonymous_variant 0.58 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.61 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.6 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.58 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038677 c.2028G>C synonymous_variant 0.61 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.59 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.59 pyrazinamide
clpC1 4038743 c.1962G>A synonymous_variant 0.58 pyrazinamide
clpC1 4038782 c.1923G>A synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4038790 c.1915C>T synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4038845 c.1860G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038848 c.1857C>T synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.51 pyrazinamide
clpC1 4038902 c.1803C>T synonymous_variant 0.49 pyrazinamide
clpC1 4038908 c.1797C>T synonymous_variant 0.49 pyrazinamide
clpC1 4038914 c.1791G>T synonymous_variant 0.47 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.46 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.48 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.43 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039037 c.1668T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039040 c.1665C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.42 pyrazinamide
clpC1 4039140 p.Glu522Val missense_variant 0.42 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039151 c.1554C>T synonymous_variant 0.42 pyrazinamide
clpC1 4039163 c.1540_1542delCTGinsAC frameshift_variant&missense_variant 0.41 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039223 c.1482C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039250 c.1455C>A synonymous_variant 0.21 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039628 c.1077C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039631 c.1074C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039664 c.1041G>T synonymous_variant 0.3 pyrazinamide
clpC1 4039679 c.1026C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039697 c.1008C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039706 c.999G>A synonymous_variant 0.39 pyrazinamide
clpC1 4039754 c.951G>T synonymous_variant 0.49 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.44 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039823 c.882T>A synonymous_variant 0.43 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039832 c.873C>A synonymous_variant 0.43 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039868 c.837C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039871 c.834C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039883 c.822G>A synonymous_variant 0.27 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040051 c.654C>A synonymous_variant 0.28 pyrazinamide
clpC1 4040063 c.642G>T synonymous_variant 0.29 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040114 c.591C>A synonymous_variant 0.36 pyrazinamide
clpC1 4040135 c.570C>T synonymous_variant 0.34 pyrazinamide
clpC1 4040138 c.567G>T synonymous_variant 0.35 pyrazinamide
clpC1 4040146 c.559C>T synonymous_variant 0.36 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.39 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040180 c.525C>G synonymous_variant 0.41 pyrazinamide
clpC1 4040210 c.495G>T synonymous_variant 0.33 pyrazinamide
clpC1 4040213 c.492T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040216 c.489C>T synonymous_variant 0.34 pyrazinamide
clpC1 4040219 c.486C>A synonymous_variant 0.35 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 0.35 pyrazinamide
clpC1 4040237 c.468C>G synonymous_variant 0.36 pyrazinamide
clpC1 4040243 c.462C>G synonymous_variant 0.36 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.39 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.429C>T synonymous_variant 0.35 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040321 c.384C>T synonymous_variant 0.32 pyrazinamide
clpC1 4040348 c.357G>T synonymous_variant 0.32 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.34 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.33 pyrazinamide
clpC1 4040366 c.339C>T synonymous_variant 0.32 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.33 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.32 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.36 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.36 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.37 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.35 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>G synonymous_variant 0.34 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>T synonymous_variant 0.34 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.34 pyrazinamide
clpC1 4040546 c.159G>T synonymous_variant 0.34 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040570 c.135C>T synonymous_variant 0.25 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040582 c.123G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040969 c.-265C>T upstream_gene_variant 0.48 pyrazinamide
clpC1 4040973 c.-269C>T upstream_gene_variant 0.44 pyrazinamide
clpC1 4040974 c.-270G>T upstream_gene_variant 0.46 pyrazinamide
clpC1 4040987 c.-283G>A upstream_gene_variant 0.37 pyrazinamide
clpC1 4040990 c.-286G>T upstream_gene_variant 0.36 pyrazinamide
clpC1 4040997 c.-293A>T upstream_gene_variant 0.33 pyrazinamide
panD 4044703 c.-422C>G upstream_gene_variant 1.0 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138273 p.Glu495Gln missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138292 c.1464A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138311 p.Arg482Gln missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138328 c.1428T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138334 c.1422G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138338 p.Ala473Asp missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138340 c.1416G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138349 c.1407G>T synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138352 c.1404C>T synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138361 c.1395C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138622 c.1134C>T synonymous_variant 0.86 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138661 c.1095T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138682 c.1074C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138696 p.Pro354Ala missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138697 c.1059C>T synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138727 c.1029C>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138775 c.981C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>A synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138817 c.939T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138822 p.Asn312Asp missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138823 c.933G>A synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138835 c.921C>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138838 c.918G>T synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138841 c.915G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138847 c.909A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138859 p.Asn299Lys missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138871 c.885C>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138880 c.876T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138889 c.867G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138897 c.859C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138898 c.858T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138910 c.846G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139231 c.525A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139243 c.513A>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4238932 c.-931A>C upstream_gene_variant 0.21 ethambutol
embC 4239426 c.-437_-435delCCAinsTG upstream_gene_variant 0.26 ethambutol
embC 4239431 c.-432C>G upstream_gene_variant 0.26 ethambutol
embC 4239437 c.-426T>C upstream_gene_variant 0.27 ethambutol Uncertain significance
embC 4239443 c.-420C>G upstream_gene_variant 0.28 ethambutol
embC 4239446 c.-417C>A upstream_gene_variant 0.28 ethambutol
embC 4239448 c.-415G>A upstream_gene_variant 0.29 ethambutol
embC 4239458 c.-405C>G upstream_gene_variant 0.35 ethambutol Uncertain significance
embC 4239463 c.-400A>G upstream_gene_variant 0.35 ethambutol
embC 4239466 c.-397G>C upstream_gene_variant 0.34 ethambutol
embC 4239475 c.-388G>A upstream_gene_variant 0.33 ethambutol Uncertain significance
embC 4239482 c.-381C>G upstream_gene_variant 0.33 ethambutol
embC 4239500 c.-363C>T upstream_gene_variant 0.3 ethambutol
embC 4239512 c.-351G>C upstream_gene_variant 0.29 ethambutol Uncertain significance
embC 4239515 c.-348C>T upstream_gene_variant 0.28 ethambutol
embC 4239546 c.-317C>T upstream_gene_variant 0.32 ethambutol
embC 4239569 c.-294A>G upstream_gene_variant 0.25 ethambutol Uncertain significance
embC 4239581 c.-282G>A upstream_gene_variant 0.25 ethambutol
embC 4239588 c.-275A>G upstream_gene_variant 0.24 ethambutol
embC 4239593 c.-270G>A upstream_gene_variant 0.23 ethambutol Not assoc w R
embC 4240600 c.738G>C synonymous_variant 0.32 ethambutol
embC 4240603 c.741G>A synonymous_variant 0.33 ethambutol
embC 4240615 c.753G>C synonymous_variant 0.35 ethambutol
embC 4240621 c.759C>G synonymous_variant 0.34 ethambutol
embC 4240629 p.Gly256Ala missense_variant 0.34 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.34 ethambutol
embC 4240642 c.780G>A synonymous_variant 0.36 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.36 ethambutol
embC 4240654 c.792C>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embC 4240655 p.Ala265Pro missense_variant 0.36 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.39 ethambutol Not assoc w R
embC 4240684 c.822C>T synonymous_variant 0.39 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.4 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.43 ethambutol
embC 4240697 p.Ala279Thr missense_variant 0.45 ethambutol Uncertain significance
embC 4240732 c.870C>T synonymous_variant 0.47 ethambutol
embC 4240747 c.885C>A synonymous_variant 0.44 ethambutol
embC 4240753 c.891C>A synonymous_variant 0.43 ethambutol
embC 4240771 c.909G>A synonymous_variant 0.42 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.41 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.4 ethambutol
embC 4240786 c.924C>G synonymous_variant 0.4 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.4 ethambutol
embC 4240795 c.933C>G synonymous_variant 0.4 ethambutol
embC 4240798 c.936C>T synonymous_variant 0.41 ethambutol
embC 4240813 p.Phe317Leu missense_variant 0.4 ethambutol
embC 4240816 c.954C>A synonymous_variant 0.37 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.38 ethambutol
embC 4240825 c.963G>A synonymous_variant 0.4 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.42 ethambutol
embC 4240861 c.999G>C synonymous_variant 0.34 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.31 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.3 ethambutol
embC 4240875 p.Ser338Thr missense_variant 0.29 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.27 ethambutol
embC 4240885 c.1023T>C synonymous_variant 0.27 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.21 ethambutol Not assoc w R
embC 4241467 c.1605C>T synonymous_variant 0.22 ethambutol
embC 4241483 c.1621_1623delGTGinsAC frameshift_variant&missense_variant 0.21 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.21 ethambutol
embC 4241501 p.Ser547Ala missense_variant 0.24 ethambutol
embC 4241504 c.1642_1644delGTGinsAC frameshift_variant&missense_variant 0.23 ethambutol
embC 4241513 c.1651_1653delTCGinsGA frameshift_variant&missense_variant 0.25 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.25 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>A synonymous_variant 0.29 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.3 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>A synonymous_variant 0.3 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.3 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.31 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.23 ethambutol
embC 4241579 p.Ile573Val missense_variant 0.23 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.22 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.22 ethambutol
embC 4241596 c.1734G>C synonymous_variant 0.25 ethambutol
embC 4241644 c.1782G>C synonymous_variant 0.25 ethambutol
embC 4241648 c.1786T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4241656 c.1794G>C synonymous_variant 0.26 ethambutol
embC 4241671 c.1809T>G synonymous_variant 0.27 ethambutol
embC 4241680 c.1818C>T synonymous_variant 0.25 ethambutol
embC 4241683 c.1821G>A synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embC 4241692 c.1830C>G synonymous_variant 0.22 ethambutol
embC 4241693 c.1831_1833delGCTinsTG frameshift_variant&missense_variant 0.22 ethambutol
embC 4241710 c.1848G>A synonymous_variant 0.24 ethambutol
embC 4241713 c.1851G>C synonymous_variant 0.25 ethambutol
embC 4241719 c.1857G>C synonymous_variant 0.25 ethambutol
embC 4241723 p.Val621Met missense_variant 0.25 ethambutol
embC 4241734 c.1872C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embC 4241743 c.1881C>G synonymous_variant 0.23 ethambutol
embC 4241750 p.Leu630Met missense_variant 0.23 ethambutol
embC 4241755 c.1893C>G synonymous_variant 0.23 ethambutol
embC 4241761 c.1899G>A synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embC 4241770 c.1908T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embC 4241788 c.1926C>T synonymous_variant 0.27 ethambutol
embC 4241800 c.1938C>T synonymous_variant 0.24 ethambutol
embC 4241809 c.1947A>G synonymous_variant 0.23 ethambutol
embC 4241818 c.1956C>T synonymous_variant 0.22 ethambutol
embC 4241824 c.1962T>C synonymous_variant 0.22 ethambutol
embC 4241836 c.1974A>G synonymous_variant 0.23 ethambutol
embC 4241995 c.2133C>G synonymous_variant 0.21 ethambutol
embC 4242022 c.2160G>T synonymous_variant 0.31 ethambutol
embC 4242047 p.Ser729Thr missense_variant 0.29 ethambutol
embC 4242061 c.2199G>A synonymous_variant 0.31 ethambutol
embC 4242070 c.2208T>G synonymous_variant 0.31 ethambutol
embC 4242073 c.2211C>A synonymous_variant 0.32 ethambutol
embC 4242075 p.Arg738His missense_variant 0.68 ethambutol
embC 4242079 c.2217T>C synonymous_variant 0.33 ethambutol
embC 4242085 c.2223A>G synonymous_variant 0.33 ethambutol
embC 4242091 c.2229T>G synonymous_variant 0.34 ethambutol
embC 4242095 c.2233_2235delGCCinsAT frameshift_variant&missense_variant 0.34 ethambutol
embC 4242112 c.2250G>C synonymous_variant 0.35 ethambutol
embC 4242121 c.2259A>G synonymous_variant 0.28 ethambutol
embC 4242127 c.2265G>A synonymous_variant 0.28 ethambutol
embC 4242133 c.2271G>A synonymous_variant 0.26 ethambutol
embC 4242138 p.Leu759Arg missense_variant 0.24 ethambutol
embC 4242142 c.2280T>C synonymous_variant 0.25 ethambutol
embC 4242151 c.2289A>C synonymous_variant 0.28 ethambutol
embC 4242158 c.2296C>T synonymous_variant 0.23 ethambutol
embC 4242161 p.Ala767Thr missense_variant 0.24 ethambutol
embC 4242166 c.2304G>A synonymous_variant 0.26 ethambutol
embC 4242175 c.2313G>T synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embC 4242179 p.Leu773Val missense_variant 0.28 ethambutol
embC 4242190 c.2328C>G synonymous_variant 0.3 ethambutol
embC 4242202 c.2340C>A synonymous_variant 0.34 ethambutol
embC 4242208 c.2346T>G synonymous_variant 0.37 ethambutol
embC 4242217 c.2355C>T synonymous_variant 0.4 ethambutol
embC 4242220 c.2358A>T synonymous_variant 0.43 ethambutol
embC 4242229 c.2367C>T synonymous_variant 0.44 ethambutol
embC 4242245 p.Thr795Ser missense_variant 0.47 ethambutol
embA 4242271 c.-962A>G upstream_gene_variant 0.54 ethambutol
embA 4242274 c.-959G>C upstream_gene_variant 0.53 ethambutol
embA 4242277 c.-956T>C upstream_gene_variant 0.53 ethambutol
embC 4242287 p.Leu809Val missense_variant 0.53 ethambutol
embC 4242293 p.Asp811Asn missense_variant 0.53 ethambutol Uncertain significance
embA 4242313 c.-920C>A upstream_gene_variant 0.53 ethambutol
embC 4242319 p.Glu819Asp missense_variant 0.5 ethambutol
embA 4242340 c.-893C>T upstream_gene_variant 0.45 ethambutol
embA 4242343 c.-890G>C upstream_gene_variant 0.44 ethambutol
embA 4242346 c.-887C>G upstream_gene_variant 0.44 ethambutol
embA 4242367 c.-866C>G upstream_gene_variant 0.36 ethambutol
embA 4242370 c.-863C>T upstream_gene_variant 0.34 ethambutol
embA 4242376 c.-857G>A upstream_gene_variant 0.32 ethambutol
embA 4242379 c.-854G>C upstream_gene_variant 0.32 ethambutol
embA 4242394 c.-839C>T upstream_gene_variant 0.25 ethambutol
embA 4242400 c.-833C>T upstream_gene_variant 0.21 ethambutol
embC 4242403 c.2541T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 0.93 ethambutol Not assoc w R
embA 4242880 c.-353A>G upstream_gene_variant 0.25 ethambutol
embC 4242883 c.3021C>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embA 4242892 c.-341G>C upstream_gene_variant 0.32 ethambutol
embA 4242901 c.-332G>C upstream_gene_variant 0.35 ethambutol
embA 4242919 c.-314A>G upstream_gene_variant 0.37 ethambutol
embA 4242940 c.-293T>C upstream_gene_variant 0.37 ethambutol
embC 4242941 p.His1027Asn missense_variant 0.38 ethambutol
embA 4242946 c.-287T>C upstream_gene_variant 0.38 ethambutol
embA 4242949 c.-284C>G upstream_gene_variant 0.38 ethambutol
embA 4242952 c.-281T>C upstream_gene_variant 0.39 ethambutol
embC 4242965 p.Ile1035Val missense_variant 0.38 ethambutol Uncertain significance
embA 4242973 c.-260G>A upstream_gene_variant 0.38 ethambutol
embA 4242976 c.-257G>A upstream_gene_variant 0.38 ethambutol
embC 4242980 p.Met1040Val missense_variant 0.37 ethambutol
embC 4242984 p.Arg1041His missense_variant 0.36 ethambutol
embA 4242988 c.-245A>C upstream_gene_variant 0.36 ethambutol
embA 4242994 c.-239G>C upstream_gene_variant 0.36 ethambutol
embC 4243007 c.3145_3147delCTCinsTG frameshift_variant&missense_variant 0.35 ethambutol
embA 4243024 c.-209T>C upstream_gene_variant 0.25 ethambutol
embA 4243025 c.-208A>C upstream_gene_variant 0.25 ethambutol
embA 4244570 c.1338C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embA 4244576 c.1344G>C synonymous_variant 0.22 ethambutol
embA 4244582 c.1350T>C synonymous_variant 0.25 ethambutol
embA 4244594 c.1362G>A synonymous_variant 0.28 ethambutol
embA 4244600 c.1368G>A synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embA 4244612 c.1380C>G synonymous_variant 0.34 ethambutol
embA 4244632 p.Thr467Ile missense_variant 0.36 ethambutol
embA 4244648 c.1416G>C synonymous_variant 0.37 ethambutol
embA 4244649 p.Asp473Ser missense_variant 0.38 ethambutol
embA 4244669 c.1437G>C synonymous_variant 0.43 ethambutol
embA 4244699 c.1467C>T synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embA 4244702 c.1470C>G synonymous_variant 0.43 ethambutol
embA 4244708 c.1476C>G synonymous_variant 0.42 ethambutol
embA 4244747 c.1515T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embA 4244753 c.1521G>C synonymous_variant 0.3 ethambutol
embA 4244762 c.1530C>T synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embA 4244764 p.Val511Ala missense_variant 0.27 ethambutol
embA 4244768 p.Glu512Asp missense_variant 0.27 ethambutol
embA 4244780 c.1548C>A synonymous_variant 0.25 ethambutol
embA 4244783 c.1551C>G synonymous_variant 0.25 ethambutol
embA 4244792 c.1560G>C synonymous_variant 0.22 ethambutol
embA 4245086 c.1854C>T synonymous_variant 0.24 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.32 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.44 ethambutol
embA 4245144 p.Gln638Lys missense_variant 0.43 ethambutol
embA 4245152 c.1920C>G synonymous_variant 0.43 ethambutol
embA 4245163 p.His644Arg missense_variant 0.47 ethambutol
embA 4245173 c.1941G>A synonymous_variant 0.51 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.53 ethambutol
embA 4245191 c.1959G>A synonymous_variant 0.54 ethambutol
embA 4245198 p.Leu656Phe missense_variant 0.54 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.56 ethambutol
embA 4245218 c.1986C>T synonymous_variant 0.56 ethambutol Not assoc w R
embA 4245224 c.1992T>C synonymous_variant 0.57 ethambutol
embA 4245233 c.2001G>C synonymous_variant 0.56 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.56 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.55 ethambutol Not assoc w R - Interim
embA 4245284 c.2052C>T synonymous_variant 0.52 ethambutol
embA 4245285 c.2053T>C synonymous_variant 0.52 ethambutol
embA 4245290 c.2058C>T synonymous_variant 0.51 ethambutol
embA 4245293 c.2061T>C synonymous_variant 0.51 ethambutol Not assoc w R - Interim
embA 4245299 c.2067A>C synonymous_variant 0.51 ethambutol Not assoc w R - Interim
embA 4245327 p.Ala699Leu missense_variant 0.46 ethambutol
embA 4245341 c.2109C>T synonymous_variant 0.48 ethambutol
embA 4245348 p.Ala706Thr missense_variant 0.48 ethambutol
embA 4245355 p.Ala708Gly missense_variant 0.47 ethambutol
embA 4245368 c.2136T>C synonymous_variant 0.44 ethambutol
embA 4245371 c.2139C>T synonymous_variant 0.43 ethambutol
embA 4245377 c.2145T>G synonymous_variant 0.4 ethambutol
embA 4245395 c.2163C>A synonymous_variant 0.35 ethambutol
embA 4245402 p.Thr724Ala missense_variant 0.32 ethambutol
embA 4245407 c.2175G>A synonymous_variant 0.28 ethambutol
embA 4245410 c.2178C>A synonymous_variant 0.25 ethambutol
embA 4245411 c.2179_2181delAGCinsCT frameshift_variant&missense_variant 0.27 ethambutol Uncertain significance
embA 4245416 c.2184C>T synonymous_variant 0.25 ethambutol
embA 4245423 c.2192_2193insACCCAC disruptive_inframe_insertion 0.26 ethambutol
embA 4245431 c.2199T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embA 4245434 c.2202G>C synonymous_variant 0.26 ethambutol
embA 4245443 c.2211C>T synonymous_variant 0.3 ethambutol
embA 4245458 c.2226G>A synonymous_variant 0.3 ethambutol
embA 4245576 p.Lys782Gln missense_variant 0.19 ethambutol
embA 4246212 p.Ser994Ala missense_variant 0.2 ethambutol
embA 4246220 c.2988T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4246238 c.-276T>G upstream_gene_variant 0.24 ethambutol
embB 4246244 c.-270G>A upstream_gene_variant 0.23 ethambutol
embB 4246250 c.-264G>C upstream_gene_variant 0.25 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.27 ethambutol
embA 4246277 c.3045G>A synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embA 4246279 p.Ala1016Val missense_variant 0.3 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.3 ethambutol
embB 4246301 c.-213C>G upstream_gene_variant 0.27 ethambutol
embA 4246302 p.Ser1024Ala missense_variant 0.27 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.29 ethambutol
embA 4246336 p.Ala1035Gly missense_variant 0.24 ethambutol
embB 4246346 c.-168C>G upstream_gene_variant 0.2 ethambutol
embB 4246750 c.237T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4246770 p.Asp86Gly missense_variant 0.3 ethambutol
embB 4246772 p.Val87Met missense_variant 0.3 ethambutol
embB 4246782 p.Ala90Asp missense_variant 0.3 ethambutol
embB 4246789 c.276A>G synonymous_variant 0.29 ethambutol
embB 4246792 c.279C>G synonymous_variant 0.29 ethambutol
embB 4246798 c.285C>T synonymous_variant 0.29 ethambutol
embB 4246804 c.291G>A synonymous_variant 0.29 ethambutol
embB 4246805 c.292_294delGTGinsAC frameshift_variant&missense_variant 0.29 ethambutol
embB 4246810 c.297G>C synonymous_variant 0.29 ethambutol
embB 4246828 c.315A>G synonymous_variant 0.29 ethambutol
embB 4246843 c.330T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4246844 c.331_333delTTGinsCC frameshift_variant&missense_variant 0.29 ethambutol
embB 4246847 c.334_336delCAGinsAC frameshift_variant&missense_variant 0.3 ethambutol
embB 4246852 c.339G>A synonymous_variant 0.3 ethambutol
embB 4246864 c.351C>G synonymous_variant 0.3 ethambutol
embB 4246879 c.366C>G synonymous_variant 0.27 ethambutol
embB 4246885 c.372C>T synonymous_variant 0.22 ethambutol
embB 4247348 p.Thr279Ala missense_variant 0.2 ethambutol
embB 4247354 p.Ala281Thr missense_variant 0.24 ethambutol
embB 4247362 c.849G>C synonymous_variant 0.29 ethambutol
embB 4247371 c.858C>G synonymous_variant 0.32 ethambutol
embB 4247386 p.His291Gln missense_variant 0.35 ethambutol
embB 4247387 p.Val292Ile missense_variant 0.35 ethambutol Uncertain significance
embB 4247401 c.888T>C synonymous_variant 0.39 ethambutol
embB 4247404 c.891G>C synonymous_variant 0.39 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.39 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.44 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.44 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>T synonymous_variant 0.44 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.45 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.39 ethambutol
embB 4247527 c.1014G>C synonymous_variant 0.35 ethambutol
embB 4247549 p.Ala346Asn missense_variant 0.3 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.3 ethambutol
embB 4247566 c.1053C>G synonymous_variant 0.27 ethambutol
embB 4247567 c.1054C>T synonymous_variant 0.26 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.27 ethambutol
embB 4247578 c.1065G>C synonymous_variant 0.29 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4247603 c.1090C>T synonymous_variant 0.25 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.21 ethambutol
embB 4247800 c.1287A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247806 c.1293G>T synonymous_variant 0.23 ethambutol
embB 4247809 c.1296G>C synonymous_variant 0.25 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.26 ethambutol
embB 4247821 c.1308T>G synonymous_variant 0.26 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4247842 c.1329T>C synonymous_variant 0.28 ethambutol
embB 4247845 c.1332G>T synonymous_variant 0.29 ethambutol
embB 4247863 c.1350C>T synonymous_variant 0.29 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.31 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.31 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.35 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.36 ethambutol
embB 4247908 c.1395C>T synonymous_variant 0.41 ethambutol
embB 4247977 c.1464C>A synonymous_variant 0.54 ethambutol
embB 4247983 c.1470G>C synonymous_variant 0.55 ethambutol
embB 4248007 c.1494C>T synonymous_variant 0.58 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.57 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.56 ethambutol Uncertain significance
embB 4248055 c.1542G>C synonymous_variant 0.54 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.52 ethambutol
embB 4248073 c.1560C>G synonymous_variant 0.52 ethambutol Not assoc w R - Interim
embB 4248085 c.1572T>C synonymous_variant 0.54 ethambutol
embB 4248106 c.1593C>T synonymous_variant 0.52 ethambutol Not assoc w R - Interim
embB 4248130 c.1617G>C synonymous_variant 0.5 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.51 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.47 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.48 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.45 ethambutol Not assoc w R - Interim
embB 4248160 c.1647C>T synonymous_variant 0.45 ethambutol Not assoc w R - Interim
embB 4248166 c.1653C>T synonymous_variant 0.43 ethambutol
embB 4248169 c.1656C>G synonymous_variant 0.42 ethambutol
embB 4248173 p.Val554Met missense_variant 0.41 ethambutol
embB 4248178 c.1665C>T synonymous_variant 0.42 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.39 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
embB 4248247 c.1734C>A synonymous_variant 0.34 ethambutol
embB 4248252 p.Gly580Ala missense_variant 0.32 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.26 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.33 ethambutol
embB 4248325 c.1812G>T synonymous_variant 0.31 ethambutol
embB 4248340 c.1827G>T synonymous_variant 0.29 ethambutol
embB 4248349 c.1836G>A synonymous_variant 0.3 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.29 ethambutol
embB 4248368 c.1855C>T synonymous_variant 0.27 ethambutol
embB 4248407 c.1894_1896delTTAinsCG frameshift_variant&missense_variant 0.25 ethambutol
embB 4248416 p.Leu635Met missense_variant 0.26 ethambutol
embB 4248430 c.1917T>C synonymous_variant 0.2 ethambutol
embB 4248989 p.Ile826Val missense_variant 0.2 ethambutol
embB 4248997 c.2484T>G synonymous_variant 0.21 ethambutol
embB 4249033 c.2520C>A synonymous_variant 0.22 ethambutol
embB 4249036 c.2523G>A synonymous_variant 0.22 ethambutol
embB 4249039 c.2526A>T synonymous_variant 0.22 ethambutol
embB 4249048 c.2535A>C synonymous_variant 0.23 ethambutol
embB 4249276 c.2763A>G synonymous_variant 0.19 ethambutol
embB 4249282 c.2769A>G synonymous_variant 0.22 ethambutol
embB 4249315 c.2802C>T synonymous_variant 0.35 ethambutol
embB 4249323 p.Ala937Asp missense_variant 0.36 ethambutol
embB 4249333 c.2820C>G synonymous_variant 0.37 ethambutol
embB 4249334 c.2821_2823delGCCinsTG frameshift_variant&missense_variant 0.37 ethambutol
embB 4249369 c.2856T>C synonymous_variant 0.45 ethambutol
embB 4249370 c.2857C>T synonymous_variant 0.47 ethambutol
embB 4249376 c.2863C>T synonymous_variant 0.5 ethambutol
embB 4249387 c.2874G>A synonymous_variant 0.49 ethambutol
embB 4249400 c.2887_2889delGTGinsAA frameshift_variant&missense_variant 0.46 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.46 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.43 ethambutol
embB 4249435 c.2922G>A synonymous_variant 0.42 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.43 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.42 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.41 ethambutol
embB 4249480 c.2967G>C synonymous_variant 0.43 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.41 ethambutol
embB 4249487 c.2974T>C synonymous_variant 0.41 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.37 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.36 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.37 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.37 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.39 ethambutol
embB 4249552 c.3039C>T synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embB 4249567 c.3054C>T synonymous_variant 0.36 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.36 ethambutol
embB 4249600 c.3087A>G synonymous_variant 0.3 ethambutol
embB 4249609 c.3096T>C synonymous_variant 0.28 ethambutol
embB 4249627 c.3114G>C synonymous_variant 0.23 ethambutol
embB 4249633 c.3120C>A synonymous_variant 0.23 ethambutol
embB 4249640 c.3127T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
aftB 4267601 c.1236C>G synonymous_variant 0.22 ethambutol
aftB 4267604 c.1233C>T synonymous_variant 0.22 ethambutol
aftB 4267610 c.1227C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
aftB 4267619 c.1218C>G synonymous_variant 0.23 ethambutol
aftB 4267634 p.Arg401His missense_variant 0.24 ethambutol
aftB 4267661 c.1176G>T synonymous_variant 0.23 ethambutol
aftB 4267685 c.1152T>C synonymous_variant 0.2 ethambutol
aftB 4268978 c.-142C>T upstream_gene_variant 0.29 ethambutol
aftB 4268985 c.-149A>G upstream_gene_variant 0.32 ethambutol
aftB 4268988 c.-152G>C upstream_gene_variant 0.33 ethambutol
ubiA 4269003 c.831C>T synonymous_variant 0.36 ethambutol Not assoc w R - Interim
aftB 4269006 c.-170T>C upstream_gene_variant 0.35 ethambutol
aftB 4269009 c.-173A>G upstream_gene_variant 0.35 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.36 ethambutol
aftB 4269018 c.-182G>A upstream_gene_variant 0.4 ethambutol
aftB 4269027 c.-191C>G upstream_gene_variant 0.41 ethambutol
aftB 4269045 c.-209G>C upstream_gene_variant 0.47 ethambutol
aftB 4269114 c.-278C>G upstream_gene_variant 0.57 ethambutol
aftB 4269123 c.-287T>C upstream_gene_variant 0.54 ethambutol
ubiA 4269138 p.Cys232Thr missense_variant 0.5 ethambutol
ubiA 4269144 c.690C>G synonymous_variant 0.52 ethambutol Not assoc w R - Interim
aftB 4269150 c.-314G>A upstream_gene_variant 0.49 ethambutol
aftB 4269164 c.-328T>C upstream_gene_variant 0.48 ethambutol
aftB 4269177 c.-341G>C upstream_gene_variant 0.45 ethambutol
aftB 4269195 c.-359C>T upstream_gene_variant 0.39 ethambutol
ubiA 4269222 c.612T>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
aftB 4269231 c.-395C>T upstream_gene_variant 0.26 ethambutol
ethA 4326352 c.1122T>G synonymous_variant 0.22 ethionamide
ethA 4326448 c.1026G>C synonymous_variant 0.22 ethionamide
ethA 4326457 c.1017T>C synonymous_variant 0.23 ethionamide
ethA 4326469 c.1005T>C synonymous_variant 0.22 ethionamide
ethA 4326474 p.Pro334Ala missense_variant 0.19 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R