TB-Profiler

Lineage	Family	RDs	Frequency
lineage1.2.1.2	Indo-Oceanic	RD239	0.11
La1.7	M.bovis	None	0.09

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
embB	4247663	p.Tyr384Asn	missense_variant	0.74	ethambutol		Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	558	c.558G>C	synonymous_variant	0.35	isoniazid
dnaA	561	c.561C>T	synonymous_variant	0.35	isoniazid
dnaA	568	p.Ala190Thr	missense_variant	0.41	isoniazid
dnaA	571	c.571T>C	synonymous_variant	0.45	isoniazid
dnaA	582	c.582A>C	synonymous_variant	0.48	isoniazid	Not assoc w R - Interim
dnaA	609	c.609C>A	synonymous_variant	0.29	isoniazid
dnaA	615	c.615C>T	synonymous_variant	0.3	isoniazid
dnaA	633	c.633T>C	synonymous_variant	0.25	isoniazid
dnaA	636	c.636C>G	synonymous_variant	0.24	isoniazid
dnaA	645	c.645A>G	synonymous_variant	0.2	isoniazid	Not assoc w R - Interim
dnaA	741	c.741T>C	synonymous_variant	0.39	isoniazid	Not assoc w R - Interim
dnaA	750	c.750C>G	synonymous_variant	0.43	isoniazid
dnaA	756	c.756T>C	synonymous_variant	0.44	isoniazid
dnaA	768	c.768C>G	synonymous_variant	0.47	isoniazid
dnaA	769	p.Ala257Ser	missense_variant	0.49	isoniazid	Uncertain significance
dnaA	777	c.777A>G	synonymous_variant	0.49	isoniazid
dnaA	795	c.795A>C	synonymous_variant	0.5	isoniazid	Not assoc w R - Interim
dnaA	805	c.805T>C	synonymous_variant	0.35	isoniazid
gyrB	5003	c.-237C>A	upstream_gene_variant	1.0	levofloxacin
gyrB	5003	c.-237C>A	upstream_gene_variant	1.0	moxifloxacin
gyrB	6112	p.Met291Ile	missense_variant	0.6	levofloxacin	Not assoc w R
gyrB	6112	p.Met291Ile	missense_variant	0.6	moxifloxacin	Not assoc w R
gyrB	6326	p.Ser363Ala	missense_variant	0.43	levofloxacin
gyrB	6326	p.Ser363Ala	missense_variant	0.43	moxifloxacin
gyrB	6346	c.1107C>T	synonymous_variant	0.52	levofloxacin	Not assoc w R - Interim
gyrB	6346	c.1107C>T	synonymous_variant	0.52	moxifloxacin	Not assoc w R - Interim
gyrA	6362	c.-940T>C	upstream_gene_variant	0.48	levofloxacin
gyrA	6362	c.-940T>C	upstream_gene_variant	0.48	moxifloxacin
gyrA	6382	c.-920A>G	upstream_gene_variant	0.63	levofloxacin
gyrA	6382	c.-920A>G	upstream_gene_variant	0.63	moxifloxacin
gyrA	6388	c.-914T>C	upstream_gene_variant	0.61	levofloxacin
gyrA	6388	c.-914T>C	upstream_gene_variant	0.61	moxifloxacin
gyrA	6640	c.-662A>C	upstream_gene_variant	0.37	levofloxacin
gyrA	6640	c.-662A>C	upstream_gene_variant	0.37	moxifloxacin
gyrA	6643	c.-659A>G	upstream_gene_variant	0.38	levofloxacin
gyrA	6643	c.-659A>G	upstream_gene_variant	0.38	moxifloxacin
gyrA	6652	c.-650C>G	upstream_gene_variant	0.45	levofloxacin
gyrA	6652	c.-650C>G	upstream_gene_variant	0.45	moxifloxacin
gyrB	6664	c.1425C>T	synonymous_variant	0.5	levofloxacin	Not assoc w R - Interim
gyrB	6664	c.1425C>T	synonymous_variant	0.5	moxifloxacin	Not assoc w R - Interim
gyrA	6673	c.-629A>T	upstream_gene_variant	0.55	levofloxacin
gyrA	6673	c.-629A>T	upstream_gene_variant	0.55	moxifloxacin
gyrB	6680	c.1441C>T	synonymous_variant	0.54	levofloxacin	Not assoc w R - Interim
gyrB	6680	c.1441C>T	synonymous_variant	0.54	moxifloxacin	Not assoc w R - Interim
gyrA	6700	c.-602T>C	upstream_gene_variant	0.62	levofloxacin
gyrA	6700	c.-602T>C	upstream_gene_variant	0.62	moxifloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	0.61	levofloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	0.61	moxifloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	0.62	levofloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	0.62	moxifloxacin
gyrA	6712	c.-590G>C	upstream_gene_variant	0.62	levofloxacin
gyrA	6712	c.-590G>C	upstream_gene_variant	0.62	moxifloxacin
gyrA	6730	c.-572A>G	upstream_gene_variant	0.62	levofloxacin
gyrA	6730	c.-572A>G	upstream_gene_variant	0.62	moxifloxacin
gyrB	6745	c.1506T>C	synonymous_variant	0.61	levofloxacin	Not assoc w R - Interim
gyrB	6745	c.1506T>C	synonymous_variant	0.61	moxifloxacin	Not assoc w R - Interim
gyrA	6751	c.-551G>C	upstream_gene_variant	0.65	levofloxacin
gyrA	6751	c.-551G>C	upstream_gene_variant	0.65	moxifloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	0.58	levofloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	0.58	moxifloxacin
gyrA	7168	c.-134C>G	upstream_gene_variant	0.48	levofloxacin
gyrA	7168	c.-134C>G	upstream_gene_variant	0.48	moxifloxacin
gyrA	7178	c.-124T>C	upstream_gene_variant	0.64	levofloxacin
gyrA	7178	c.-124T>C	upstream_gene_variant	0.64	moxifloxacin
gyrB	7198	c.1959C>T	synonymous_variant	0.59	levofloxacin	Not assoc w R - Interim
gyrB	7198	c.1959C>T	synonymous_variant	0.59	moxifloxacin
gyrA	7204	c.-98C>T	upstream_gene_variant	0.45	levofloxacin
gyrA	7204	c.-98C>T	upstream_gene_variant	0.45	moxifloxacin
gyrB	7210	p.Asp657Glu	missense_variant	0.5	levofloxacin
gyrB	7210	p.Asp657Glu	missense_variant	0.5	moxifloxacin
gyrB	7216	c.1977G>C	synonymous_variant	0.45	levofloxacin	Not assoc w R - Interim
gyrB	7216	c.1977G>C	synonymous_variant	0.45	moxifloxacin
gyrA	7225	c.-77T>C	upstream_gene_variant	0.43	levofloxacin
gyrA	7225	c.-77T>C	upstream_gene_variant	0.43	moxifloxacin
gyrB	7234	c.1995C>T	synonymous_variant	0.4	levofloxacin	Not assoc w R - Interim
gyrB	7234	c.1995C>T	synonymous_variant	0.4	moxifloxacin	Not assoc w R - Interim
gyrA	7243	c.-59G>A	upstream_gene_variant	0.42	levofloxacin
gyrA	7243	c.-59G>A	upstream_gene_variant	0.42	moxifloxacin
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7394	c.93T>C	synonymous_variant	0.52	levofloxacin	Not assoc w R - Interim
gyrA	7394	c.93T>C	synonymous_variant	0.52	moxifloxacin
gyrA	7406	c.105G>C	synonymous_variant	0.52	levofloxacin
gyrA	7406	c.105G>C	synonymous_variant	0.52	moxifloxacin
gyrA	7412	c.111C>G	synonymous_variant	0.48	levofloxacin
gyrA	7412	c.111C>G	synonymous_variant	0.48	moxifloxacin
gyrA	7421	c.120G>C	synonymous_variant	0.46	levofloxacin
gyrA	7421	c.120G>C	synonymous_variant	0.46	moxifloxacin
gyrA	7427	c.126G>A	synonymous_variant	0.45	levofloxacin	Not assoc w R - Interim
gyrA	7427	c.126G>A	synonymous_variant	0.45	moxifloxacin	Not assoc w R - Interim
gyrA	7430	c.129G>A	synonymous_variant	0.45	levofloxacin
gyrA	7430	c.129G>A	synonymous_variant	0.45	moxifloxacin
gyrA	7433	c.132G>C	synonymous_variant	0.44	levofloxacin
gyrA	7433	c.132G>C	synonymous_variant	0.44	moxifloxacin
gyrA	7442	c.141G>C	synonymous_variant	0.42	levofloxacin
gyrA	7442	c.141G>C	synonymous_variant	0.42	moxifloxacin
gyrA	7451	c.150C>G	synonymous_variant	0.38	levofloxacin
gyrA	7451	c.150C>G	synonymous_variant	0.38	moxifloxacin
gyrA	7457	c.156T>C	synonymous_variant	0.36	levofloxacin
gyrA	7457	c.156T>C	synonymous_variant	0.36	moxifloxacin
gyrA	7466	c.165G>A	synonymous_variant	0.66	levofloxacin
gyrA	7466	c.165G>A	synonymous_variant	0.66	moxifloxacin
gyrA	7469	c.168C>G	synonymous_variant	0.31	levofloxacin	Not assoc w R - Interim
gyrA	7469	c.168C>G	synonymous_variant	0.31	moxifloxacin	Not assoc w R - Interim
gyrA	7523	c.222C>G	synonymous_variant	0.24	levofloxacin	Not assoc w R - Interim
gyrA	7523	c.222C>G	synonymous_variant	0.24	moxifloxacin	Not assoc w R - Interim
gyrA	7526	c.225G>C	synonymous_variant	0.29	levofloxacin	Not assoc w R - Interim
gyrA	7526	c.225G>C	synonymous_variant	0.29	moxifloxacin	Not assoc w R - Interim
gyrA	7532	c.231T>G	synonymous_variant	0.29	levofloxacin	Not assoc w R - Interim
gyrA	7532	c.231T>G	synonymous_variant	0.29	moxifloxacin	Not assoc w R - Interim
gyrA	7547	c.246C>T	synonymous_variant	0.35	levofloxacin	Not assoc w R - Interim
gyrA	7547	c.246C>T	synonymous_variant	0.35	moxifloxacin	Not assoc w R - Interim
gyrA	7565	c.264C>T	synonymous_variant	0.4	levofloxacin	Not assoc w R - Interim
gyrA	7565	c.264C>T	synonymous_variant	0.4	moxifloxacin	Not assoc w R - Interim
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7601	c.300C>G	synonymous_variant	0.59	levofloxacin	Not assoc w R - Interim
gyrA	7601	c.300C>G	synonymous_variant	0.59	moxifloxacin	Not assoc w R - Interim
gyrA	7607	c.306C>G	synonymous_variant	0.55	levofloxacin	Not assoc w R - Interim
gyrA	7607	c.306C>G	synonymous_variant	0.55	moxifloxacin	Not assoc w R - Interim
gyrA	7631	c.330G>C	synonymous_variant	0.53	levofloxacin
gyrA	7631	c.330G>C	synonymous_variant	0.53	moxifloxacin
gyrA	7637	c.336C>G	synonymous_variant	0.53	levofloxacin
gyrA	7637	c.336C>G	synonymous_variant	0.53	moxifloxacin
gyrA	7643	c.342C>G	synonymous_variant	0.5	levofloxacin
gyrA	7643	c.342C>G	synonymous_variant	0.5	moxifloxacin
gyrA	7658	c.357A>G	synonymous_variant	0.52	levofloxacin
gyrA	7658	c.357A>G	synonymous_variant	0.52	moxifloxacin
gyrA	7661	c.360C>G	synonymous_variant	0.54	levofloxacin
gyrA	7661	c.360C>G	synonymous_variant	0.54	moxifloxacin
gyrA	7670	c.369A>G	synonymous_variant	0.42	levofloxacin
gyrA	7670	c.369A>G	synonymous_variant	0.42	moxifloxacin
gyrA	7728	c.427_429delAGGinsCGC	synonymous_variant	0.41	levofloxacin
gyrA	7728	c.427_429delAGGinsCGC	synonymous_variant	0.41	moxifloxacin
gyrA	7745	c.444G>A	synonymous_variant	0.45	levofloxacin	Not assoc w R - Interim
gyrA	7745	c.444G>A	synonymous_variant	0.45	moxifloxacin	Not assoc w R - Interim
gyrA	7763	c.462T>G	synonymous_variant	0.42	levofloxacin
gyrA	7763	c.462T>G	synonymous_variant	0.42	moxifloxacin
gyrA	7784	c.483A>G	synonymous_variant	0.59	levofloxacin
gyrA	7784	c.483A>G	synonymous_variant	0.59	moxifloxacin
gyrA	7793	c.492G>C	synonymous_variant	0.58	levofloxacin
gyrA	7793	c.492G>C	synonymous_variant	0.58	moxifloxacin
gyrA	7796	c.495G>C	synonymous_variant	0.56	levofloxacin
gyrA	7796	c.495G>C	synonymous_variant	0.56	moxifloxacin
gyrA	7799	c.498A>G	synonymous_variant	0.55	levofloxacin	Not assoc w R - Interim
gyrA	7799	c.498A>G	synonymous_variant	0.55	moxifloxacin	Not assoc w R - Interim
gyrA	7832	c.531G>T	synonymous_variant	0.44	levofloxacin
gyrA	7832	c.531G>T	synonymous_variant	0.44	moxifloxacin
gyrA	7835	c.534A>G	synonymous_variant	0.45	levofloxacin	Not assoc w R - Interim
gyrA	7835	c.534A>G	synonymous_variant	0.45	moxifloxacin	Not assoc w R - Interim
gyrA	7847	c.546G>C	synonymous_variant	0.5	levofloxacin
gyrA	7847	c.546G>C	synonymous_variant	0.5	moxifloxacin
gyrA	7853	c.552C>T	synonymous_variant	0.49	levofloxacin	Not assoc w R - Interim
gyrA	7853	c.552C>T	synonymous_variant	0.49	moxifloxacin	Not assoc w R - Interim
gyrA	7859	c.558A>C	synonymous_variant	0.5	levofloxacin
gyrA	7859	c.558A>C	synonymous_variant	0.5	moxifloxacin
gyrA	7886	c.585T>C	synonymous_variant	0.46	levofloxacin
gyrA	7886	c.585T>C	synonymous_variant	0.46	moxifloxacin
gyrA	7892	c.591G>C	synonymous_variant	0.43	levofloxacin
gyrA	7892	c.591G>C	synonymous_variant	0.43	moxifloxacin
gyrA	7898	p.Asp199Glu	missense_variant	0.37	levofloxacin
gyrA	7898	p.Asp199Glu	missense_variant	0.37	moxifloxacin
gyrA	7911	p.Ala204Cys	missense_variant	0.29	levofloxacin
gyrA	7911	p.Ala204Cys	missense_variant	0.29	moxifloxacin
gyrA	7922	c.621T>C	synonymous_variant	0.28	levofloxacin
gyrA	7922	c.621T>C	synonymous_variant	0.28	moxifloxacin
gyrA	7923	p.His208Tyr	missense_variant	0.28	levofloxacin
gyrA	7923	p.His208Tyr	missense_variant	0.28	moxifloxacin
gyrA	8084	c.783G>A	synonymous_variant	0.48	levofloxacin
gyrA	8084	c.783G>A	synonymous_variant	0.48	moxifloxacin
gyrA	8090	c.789C>A	synonymous_variant	0.5	levofloxacin
gyrA	8090	c.789C>A	synonymous_variant	0.5	moxifloxacin
gyrA	8096	c.795T>C	synonymous_variant	0.52	levofloxacin
gyrA	8096	c.795T>C	synonymous_variant	0.52	moxifloxacin
gyrA	8099	c.798T>C	synonymous_variant	0.58	levofloxacin
gyrA	8099	c.798T>C	synonymous_variant	0.58	moxifloxacin
gyrA	8106	c.805C>T	synonymous_variant	0.62	levofloxacin	Not assoc w R - Interim
gyrA	8106	c.805C>T	synonymous_variant	0.62	moxifloxacin	Not assoc w R - Interim
gyrA	8121	c.820T>C	synonymous_variant	0.5	levofloxacin
gyrA	8121	c.820T>C	synonymous_variant	0.5	moxifloxacin
gyrA	8126	c.825G>C	synonymous_variant	0.52	levofloxacin	Not assoc w R - Interim
gyrA	8126	c.825G>C	synonymous_variant	0.52	moxifloxacin	Not assoc w R - Interim
gyrA	8156	c.855T>C	synonymous_variant	0.57	levofloxacin
gyrA	8156	c.855T>C	synonymous_variant	0.57	moxifloxacin
gyrA	8177	c.876A>C	synonymous_variant	0.43	levofloxacin
gyrA	8177	c.876A>C	synonymous_variant	0.43	moxifloxacin
gyrA	8184	p.Lys295Arg	missense_variant	0.32	levofloxacin
gyrA	8184	p.Lys295Arg	missense_variant	0.32	moxifloxacin
gyrA	8324	c.1023T>C	synonymous_variant	0.5	levofloxacin
gyrA	8324	c.1023T>C	synonymous_variant	0.5	moxifloxacin
gyrA	8327	c.1026C>G	synonymous_variant	0.5	levofloxacin
gyrA	8327	c.1026C>G	synonymous_variant	0.5	moxifloxacin
gyrA	8328	p.Ala343Thr	missense_variant	0.5	levofloxacin
gyrA	8328	p.Ala343Thr	missense_variant	0.5	moxifloxacin
gyrA	8339	c.1038A>G	synonymous_variant	0.54	levofloxacin
gyrA	8339	c.1038A>G	synonymous_variant	0.54	moxifloxacin
gyrA	8340	p.Ala347Ser	missense_variant	0.54	levofloxacin	Uncertain significance
gyrA	8340	p.Ala347Ser	missense_variant	0.54	moxifloxacin	Uncertain significance
gyrA	8345	c.1044C>T	synonymous_variant	0.64	levofloxacin	Not assoc w R - Interim
gyrA	8345	c.1044C>T	synonymous_variant	0.64	moxifloxacin
gyrA	8366	c.1065G>C	synonymous_variant	0.55	levofloxacin
gyrA	8366	c.1065G>C	synonymous_variant	0.55	moxifloxacin
gyrA	8571	c.1270C>T	synonymous_variant	0.35	levofloxacin
gyrA	8571	c.1270C>T	synonymous_variant	0.35	moxifloxacin
gyrA	8603	c.1302A>G	synonymous_variant	0.63	levofloxacin	Not assoc w R - Interim
gyrA	8603	c.1302A>G	synonymous_variant	0.63	moxifloxacin	Not assoc w R - Interim
gyrA	8627	c.1326C>T	synonymous_variant	0.6	levofloxacin	Not assoc w R - Interim
gyrA	8627	c.1326C>T	synonymous_variant	0.6	moxifloxacin	Not assoc w R - Interim
gyrA	8636	c.1335A>T	synonymous_variant	0.58	levofloxacin
gyrA	8636	c.1335A>T	synonymous_variant	0.58	moxifloxacin
gyrA	8642	c.1341A>G	synonymous_variant	0.54	levofloxacin
gyrA	8642	c.1341A>G	synonymous_variant	0.54	moxifloxacin
gyrA	8645	c.1344C>T	synonymous_variant	0.54	levofloxacin	Not assoc w R - Interim
gyrA	8645	c.1344C>T	synonymous_variant	0.54	moxifloxacin	Not assoc w R - Interim
gyrA	8648	c.1347G>A	synonymous_variant	0.54	levofloxacin
gyrA	8648	c.1347G>A	synonymous_variant	0.54	moxifloxacin
gyrA	8655	p.Ile452Val	missense_variant	0.54	levofloxacin
gyrA	8655	p.Ile452Val	missense_variant	0.54	moxifloxacin
gyrA	8672	c.1371A>G	synonymous_variant	0.48	levofloxacin	Not assoc w R - Interim
gyrA	8672	c.1371A>G	synonymous_variant	0.48	moxifloxacin	Not assoc w R - Interim
gyrA	8678	c.1377G>A	synonymous_variant	0.48	levofloxacin
gyrA	8678	c.1377G>A	synonymous_variant	0.48	moxifloxacin
gyrA	8684	c.1383G>A	synonymous_variant	0.46	levofloxacin
gyrA	8684	c.1383G>A	synonymous_variant	0.46	moxifloxacin
gyrA	8693	c.1392T>C	synonymous_variant	0.42	levofloxacin
gyrA	8693	c.1392T>C	synonymous_variant	0.42	moxifloxacin
gyrA	8783	c.1482G>T	synonymous_variant	0.42	levofloxacin
gyrA	8783	c.1482G>T	synonymous_variant	0.42	moxifloxacin
gyrA	8786	c.1485T>C	synonymous_variant	0.39	levofloxacin
gyrA	8786	c.1485T>C	synonymous_variant	0.39	moxifloxacin
gyrA	8792	c.1491G>C	synonymous_variant	0.37	levofloxacin
gyrA	8792	c.1491G>C	synonymous_variant	0.37	moxifloxacin
gyrA	8810	c.1509A>G	synonymous_variant	0.52	levofloxacin
gyrA	8810	c.1509A>G	synonymous_variant	0.52	moxifloxacin
gyrA	8813	c.1512C>T	synonymous_variant	0.57	levofloxacin	Not assoc w R - Interim
gyrA	8813	c.1512C>T	synonymous_variant	0.57	moxifloxacin
gyrA	8825	c.1524G>A	synonymous_variant	0.6	levofloxacin
gyrA	8825	c.1524G>A	synonymous_variant	0.6	moxifloxacin
gyrA	8828	c.1527T>C	synonymous_variant	0.58	levofloxacin
gyrA	8828	c.1527T>C	synonymous_variant	0.58	moxifloxacin
gyrA	8829	c.1528T>C	synonymous_variant	0.58	levofloxacin	Not assoc w R - Interim
gyrA	8829	c.1528T>C	synonymous_variant	0.58	moxifloxacin	Not assoc w R - Interim
gyrA	8840	c.1539C>T	synonymous_variant	0.61	levofloxacin
gyrA	8840	c.1539C>T	synonymous_variant	0.61	moxifloxacin
gyrA	8852	c.1551T>C	synonymous_variant	0.69	levofloxacin
gyrA	8852	c.1551T>C	synonymous_variant	0.69	moxifloxacin
gyrA	8858	c.1557T>C	synonymous_variant	0.64	levofloxacin
gyrA	8858	c.1557T>C	synonymous_variant	0.64	moxifloxacin
gyrA	8870	c.1569G>C	synonymous_variant	0.61	levofloxacin	Not assoc w R - Interim
gyrA	8870	c.1569G>C	synonymous_variant	0.61	moxifloxacin	Not assoc w R - Interim
gyrA	8873	c.1572A>G	synonymous_variant	0.58	levofloxacin	Not assoc w R - Interim
gyrA	8873	c.1572A>G	synonymous_variant	0.58	moxifloxacin	Not assoc w R - Interim
gyrA	8876	c.1575C>T	synonymous_variant	0.59	levofloxacin
gyrA	8876	c.1575C>T	synonymous_variant	0.59	moxifloxacin
gyrA	8903	c.1602T>C	synonymous_variant	0.57	levofloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.57	moxifloxacin	Not assoc w R - Interim
gyrA	8915	c.1614A>G	synonymous_variant	0.51	levofloxacin	Not assoc w R - Interim
gyrA	8915	c.1614A>G	synonymous_variant	0.51	moxifloxacin	Not assoc w R - Interim
gyrA	8918	c.1617C>G	synonymous_variant	0.51	levofloxacin
gyrA	8918	c.1617C>G	synonymous_variant	0.51	moxifloxacin
gyrA	8939	c.1638T>C	synonymous_variant	0.46	levofloxacin
gyrA	8939	c.1638T>C	synonymous_variant	0.46	moxifloxacin
gyrA	8942	c.1641G>C	synonymous_variant	0.43	levofloxacin
gyrA	8942	c.1641G>C	synonymous_variant	0.43	moxifloxacin
gyrA	8946	c.1645_1647delTTGinsCTC	synonymous_variant	0.35	levofloxacin	Not assoc w R - Interim
gyrA	8946	c.1645_1647delTTGinsCTC	synonymous_variant	0.35	moxifloxacin	Not assoc w R - Interim
gyrA	8966	c.1665C>G	synonymous_variant	0.4	levofloxacin	Not assoc w R - Interim
gyrA	8966	c.1665C>G	synonymous_variant	0.4	moxifloxacin	Not assoc w R - Interim
gyrA	8967	p.Ala556Arg	missense_variant	0.4	levofloxacin
gyrA	8967	p.Ala556Arg	missense_variant	0.4	moxifloxacin
gyrA	8996	c.1695T>C	synonymous_variant	0.52	levofloxacin
gyrA	8996	c.1695T>C	synonymous_variant	0.52	moxifloxacin
gyrA	8998	p.Leu566Trp	missense_variant	0.53	levofloxacin	Uncertain significance
gyrA	8998	p.Leu566Trp	missense_variant	0.53	moxifloxacin	Uncertain significance
gyrA	9023	c.1722A>C	synonymous_variant	0.62	levofloxacin	Not assoc w R - Interim
gyrA	9023	c.1722A>C	synonymous_variant	0.62	moxifloxacin	Not assoc w R - Interim
gyrA	9029	c.1728T>C	synonymous_variant	0.57	levofloxacin
gyrA	9029	c.1728T>C	synonymous_variant	0.57	moxifloxacin
gyrA	9032	c.1731T>C	synonymous_variant	0.56	levofloxacin
gyrA	9032	c.1731T>C	synonymous_variant	0.56	moxifloxacin
gyrA	9050	p.Asp583Glu	missense_variant	0.61	levofloxacin	Uncertain significance
gyrA	9050	p.Asp583Glu	missense_variant	0.61	moxifloxacin	Uncertain significance
gyrA	9051	c.1750T>C	synonymous_variant	0.61	levofloxacin
gyrA	9051	c.1750T>C	synonymous_variant	0.61	moxifloxacin
gyrA	9056	c.1755C>G	synonymous_variant	0.62	levofloxacin	Not assoc w R - Interim
gyrA	9056	c.1755C>G	synonymous_variant	0.62	moxifloxacin	Not assoc w R - Interim
gyrA	9068	c.1767G>C	synonymous_variant	0.67	levofloxacin
gyrA	9068	c.1767G>C	synonymous_variant	0.67	moxifloxacin
gyrA	9080	c.1779G>C	synonymous_variant	0.67	levofloxacin
gyrA	9080	c.1779G>C	synonymous_variant	0.67	moxifloxacin
gyrA	9089	c.1788G>C	synonymous_variant	0.63	levofloxacin
gyrA	9089	c.1788G>C	synonymous_variant	0.63	moxifloxacin
gyrA	9092	c.1791C>G	synonymous_variant	0.63	levofloxacin
gyrA	9092	c.1791C>G	synonymous_variant	0.63	moxifloxacin
gyrA	9099	c.1798_1800delTTAinsCTG	synonymous_variant	0.47	levofloxacin
gyrA	9099	c.1798_1800delTTAinsCTG	synonymous_variant	0.47	moxifloxacin
gyrA	9143	c.1842T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9200	c.1899A>G	synonymous_variant	0.29	levofloxacin	Not assoc w R - Interim
gyrA	9200	c.1899A>G	synonymous_variant	0.29	moxifloxacin	Not assoc w R - Interim
gyrA	9209	c.1908G>A	synonymous_variant	0.35	levofloxacin
gyrA	9209	c.1908G>A	synonymous_variant	0.35	moxifloxacin
gyrA	9212	c.1911G>C	synonymous_variant	0.34	levofloxacin
gyrA	9212	c.1911G>C	synonymous_variant	0.34	moxifloxacin
gyrA	9230	c.1929T>C	synonymous_variant	0.46	levofloxacin
gyrA	9230	c.1929T>C	synonymous_variant	0.46	moxifloxacin
gyrA	9236	c.1935G>C	synonymous_variant	0.46	levofloxacin
gyrA	9236	c.1935G>C	synonymous_variant	0.46	moxifloxacin
gyrA	9239	c.1938C>G	synonymous_variant	0.47	levofloxacin
gyrA	9239	c.1938C>G	synonymous_variant	0.47	moxifloxacin
gyrA	9242	c.1941A>G	synonymous_variant	0.51	levofloxacin
gyrA	9242	c.1941A>G	synonymous_variant	0.51	moxifloxacin
gyrA	9251	c.1950G>C	synonymous_variant	0.58	levofloxacin
gyrA	9251	c.1950G>C	synonymous_variant	0.58	moxifloxacin
gyrA	9267	p.Asn656Gly	missense_variant	0.6	levofloxacin
gyrA	9267	p.Asn656Gly	missense_variant	0.6	moxifloxacin
gyrA	9291	c.1990C>T	synonymous_variant	0.77	levofloxacin
gyrA	9291	c.1990C>T	synonymous_variant	0.77	moxifloxacin
gyrA	9304	p.Gly668Glu	missense_variant	1.0	levofloxacin
gyrA	9304	p.Gly668Glu	missense_variant	1.0	moxifloxacin
gyrA	9308	p.Asp669Glu	missense_variant	0.75	levofloxacin
gyrA	9308	p.Asp669Glu	missense_variant	0.75	moxifloxacin
gyrA	9315	c.2014C>T	synonymous_variant	0.71	levofloxacin	Not assoc w R - Interim
gyrA	9315	c.2014C>T	synonymous_variant	0.71	moxifloxacin	Not assoc w R - Interim
gyrA	9335	c.2034G>C	synonymous_variant	0.72	levofloxacin
gyrA	9335	c.2034G>C	synonymous_variant	0.72	moxifloxacin
gyrA	9345	c.2044A>C	synonymous_variant	0.69	levofloxacin
gyrA	9345	c.2044A>C	synonymous_variant	0.69	moxifloxacin
gyrA	9374	c.2073G>C	synonymous_variant	0.61	levofloxacin
gyrA	9374	c.2073G>C	synonymous_variant	0.61	moxifloxacin
gyrA	9377	c.2076A>G	synonymous_variant	0.63	levofloxacin	Not assoc w R - Interim
gyrA	9377	c.2076A>G	synonymous_variant	0.63	moxifloxacin	Not assoc w R - Interim
gyrA	9383	c.2082T>C	synonymous_variant	0.62	levofloxacin
gyrA	9383	c.2082T>C	synonymous_variant	0.62	moxifloxacin
gyrA	9386	c.2085T>C	synonymous_variant	0.61	levofloxacin	Not assoc w R - Interim
gyrA	9386	c.2085T>C	synonymous_variant	0.61	moxifloxacin	Not assoc w R - Interim
gyrA	9395	c.2094G>C	synonymous_variant	0.57	levofloxacin	Not assoc w R - Interim
gyrA	9395	c.2094G>C	synonymous_variant	0.57	moxifloxacin	Not assoc w R - Interim
gyrA	9398	c.2097T>C	synonymous_variant	0.59	levofloxacin
gyrA	9398	c.2097T>C	synonymous_variant	0.59	moxifloxacin
gyrA	9419	c.2118T>C	synonymous_variant	0.52	levofloxacin
gyrA	9419	c.2118T>C	synonymous_variant	0.52	moxifloxacin
gyrA	9420	p.Ile707Ala	missense_variant	0.52	levofloxacin
gyrA	9420	p.Ile707Ala	missense_variant	0.52	moxifloxacin
Rv0010c	13298	p.Ile87Met	missense_variant	1.0	isoniazid	Not assoc w R
Rv0010c	13460	c.99T>C	synonymous_variant	1.0	isoniazid	Not assoc w R
Rv0010c	13482	p.Ala26Val	missense_variant	1.0	isoniazid	Not assoc w R
Rv0010c	13891	c.-335_-333delTCGinsGCC	upstream_gene_variant	0.44	isoniazid
Rv0010c	13903	c.-345A>G	upstream_gene_variant	0.43	isoniazid
fgd1	491217	c.435T>G	synonymous_variant	0.26	pretomanid
					delamanid
					clofazimine
fgd1	491232	c.450T>C	synonymous_variant	0.42	pretomanid
					delamanid
					clofazimine
fgd1	491241	p.Asp153Glu	missense_variant	0.57	pretomanid
					delamanid
					clofazimine
fgd1	491244	c.462T>C	synonymous_variant	0.57	pretomanid
					delamanid
					clofazimine
fgd1	491259	c.477T>C	synonymous_variant	0.56	pretomanid
					delamanid
					clofazimine
fgd1	491268	c.486C>T	synonymous_variant	0.57	pretomanid
					delamanid
					clofazimine
fgd1	491283	p.Asp167Glu	missense_variant	0.63	pretomanid
					delamanid
					clofazimine
fgd1	491286	c.504G>C	synonymous_variant	0.65	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
fgd1	491316	c.534C>G	synonymous_variant	0.79	pretomanid
					delamanid
					clofazimine
fgd1	491325	c.543G>C	synonymous_variant	0.78	pretomanid
					delamanid
					clofazimine
fgd1	491328	c.546C>G	synonymous_variant	0.78	pretomanid
					delamanid
					clofazimine
fgd1	491349	c.567T>C	synonymous_variant	0.5	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
fgd1	491491	p.Pro237Thr	missense_variant	0.5	pretomanid
					delamanid
					clofazimine
fgd1	491502	p.Glu240Asp	missense_variant	0.46	pretomanid
					delamanid
					clofazimine
fgd1	491508	c.726A>G	synonymous_variant	0.43	pretomanid
					delamanid
					clofazimine
fgd1	491509	c.727T>C	synonymous_variant	0.46	pretomanid
					delamanid
					clofazimine
fgd1	491512	p.Asn244Glu	missense_variant	0.46	pretomanid
					delamanid
					clofazimine
fgd1	491526	c.744T>C	synonymous_variant	0.54	pretomanid
					delamanid
					clofazimine
fgd1	491532	c.750G>A	synonymous_variant	0.52	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
fgd1	491542	c.760_762delTTGinsCTC	synonymous_variant	0.5	pretomanid
					delamanid
					clofazimine
fgd1	491546	p.Thr255Ser	missense_variant	0.5	pretomanid
					delamanid
					clofazimine
fgd1	491550	c.768T>C	synonymous_variant	0.48	pretomanid
					delamanid
					clofazimine
fgd1	491742	c.960T>C	synonymous_variant	1.0	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R
mshA	574673	c.-675A>G	upstream_gene_variant	0.4	isoniazid
mshA	574673	c.-675A>G	upstream_gene_variant	0.4	ethionamide
mshA	574677	c.-671A>G	upstream_gene_variant	0.42	isoniazid
mshA	574677	c.-671A>G	upstream_gene_variant	0.42	ethionamide
mshA	574680	c.-668T>A	upstream_gene_variant	0.45	isoniazid
mshA	574680	c.-668T>A	upstream_gene_variant	0.45	ethionamide
mshA	574688	c.-660G>C	upstream_gene_variant	0.49	isoniazid	Uncertain significance
mshA	574688	c.-660G>C	upstream_gene_variant	0.49	ethionamide	Uncertain significance
mshA	574694	c.-654C>G	upstream_gene_variant	0.54	isoniazid
mshA	574694	c.-654C>G	upstream_gene_variant	0.54	ethionamide
mshA	574700	c.-648C>G	upstream_gene_variant	0.55	isoniazid
mshA	574700	c.-648C>G	upstream_gene_variant	0.55	ethionamide
mshA	574703	c.-645C>T	upstream_gene_variant	0.55	isoniazid
mshA	574703	c.-645C>T	upstream_gene_variant	0.55	ethionamide
mshA	574712	c.-636A>G	upstream_gene_variant	0.52	isoniazid
mshA	574712	c.-636A>G	upstream_gene_variant	0.52	ethionamide
mshA	574718	c.-630A>G	upstream_gene_variant	0.53	isoniazid
mshA	574718	c.-630A>G	upstream_gene_variant	0.53	ethionamide
mshA	574731	c.-617A>G	upstream_gene_variant	0.55	isoniazid
mshA	574731	c.-617A>G	upstream_gene_variant	0.55	ethionamide
mshA	574739	c.-609T>C	upstream_gene_variant	0.55	isoniazid
mshA	574739	c.-609T>C	upstream_gene_variant	0.55	ethionamide
mshA	574742	c.-606G>A	upstream_gene_variant	0.53	isoniazid
mshA	574742	c.-606G>A	upstream_gene_variant	0.53	ethionamide
mshA	574763	c.-585T>C	upstream_gene_variant	0.55	isoniazid	Uncertain significance
mshA	574763	c.-585T>C	upstream_gene_variant	0.55	ethionamide
mshA	574769	c.-579C>G	upstream_gene_variant	0.44	isoniazid
mshA	574769	c.-579C>G	upstream_gene_variant	0.44	ethionamide
mshA	574772	c.-576C>G	upstream_gene_variant	0.44	isoniazid
mshA	574772	c.-576C>G	upstream_gene_variant	0.44	ethionamide
mshA	574784	c.-564C>A	upstream_gene_variant	0.42	isoniazid
mshA	574784	c.-564C>A	upstream_gene_variant	0.42	ethionamide
mshA	574793	c.-555C>G	upstream_gene_variant	0.36	isoniazid
mshA	574793	c.-555C>G	upstream_gene_variant	0.36	ethionamide
mshA	574796	c.-552C>A	upstream_gene_variant	0.34	isoniazid
mshA	574796	c.-552C>A	upstream_gene_variant	0.34	ethionamide
mshA	574799	c.-549T>G	upstream_gene_variant	0.34	isoniazid
mshA	574799	c.-549T>G	upstream_gene_variant	0.34	ethionamide
mshA	574802	c.-546A>G	upstream_gene_variant	0.34	isoniazid
mshA	574802	c.-546A>G	upstream_gene_variant	0.34	ethionamide
mshA	574803	c.-545A>C	upstream_gene_variant	0.33	isoniazid
mshA	574803	c.-545A>C	upstream_gene_variant	0.33	ethionamide
mshA	574814	c.-534T>C	upstream_gene_variant	0.33	isoniazid
mshA	574814	c.-534T>C	upstream_gene_variant	0.33	ethionamide
mshA	574815	c.-533A>T	upstream_gene_variant	0.33	isoniazid
mshA	574815	c.-533A>T	upstream_gene_variant	0.33	ethionamide
mshA	574829	c.-519G>A	upstream_gene_variant	0.3	isoniazid
mshA	574829	c.-519G>A	upstream_gene_variant	0.3	ethionamide
mshA	575488	c.141T>A	synonymous_variant	0.45	isoniazid
mshA	575488	c.141T>A	synonymous_variant	0.45	ethionamide
mshA	575491	c.144G>C	synonymous_variant	0.41	isoniazid
mshA	575491	c.144G>C	synonymous_variant	0.41	ethionamide
mshA	575497	c.150G>C	synonymous_variant	0.48	isoniazid
mshA	575497	c.150G>C	synonymous_variant	0.48	ethionamide
mshA	575512	c.165A>G	synonymous_variant	0.54	isoniazid
mshA	575512	c.165A>G	synonymous_variant	0.54	ethionamide
mshA	575527	c.180G>T	synonymous_variant	0.56	isoniazid
mshA	575527	c.180G>T	synonymous_variant	0.56	ethionamide
mshA	575554	c.207C>T	synonymous_variant	0.62	isoniazid
mshA	575554	c.207C>T	synonymous_variant	0.62	ethionamide
mshA	575561	p.Met72Val	missense_variant	0.62	isoniazid
mshA	575561	p.Met72Val	missense_variant	0.62	ethionamide
mshA	575572	c.225T>C	synonymous_variant	0.62	isoniazid
mshA	575572	c.225T>C	synonymous_variant	0.62	ethionamide
mshA	575588	p.Arg81Lys	missense_variant	0.55	isoniazid
mshA	575588	p.Arg81Lys	missense_variant	0.55	ethionamide
mshA	575593	c.246G>C	synonymous_variant	0.52	isoniazid
mshA	575593	c.246G>C	synonymous_variant	0.52	ethionamide
mshA	575629	c.282A>C	synonymous_variant	0.47	isoniazid
mshA	575629	c.282A>C	synonymous_variant	0.47	ethionamide
mshA	575632	c.285G>C	synonymous_variant	0.41	isoniazid
mshA	575632	c.285G>C	synonymous_variant	0.41	ethionamide
mshA	575635	c.288A>C	synonymous_variant	0.4	isoniazid	Not assoc w R - Interim
mshA	575635	c.288A>C	synonymous_variant	0.4	ethionamide
mshA	575638	c.291T>C	synonymous_variant	0.4	isoniazid
mshA	575638	c.291T>C	synonymous_variant	0.4	ethionamide
mshA	575641	c.294A>G	synonymous_variant	0.41	isoniazid
mshA	575641	c.294A>G	synonymous_variant	0.41	ethionamide
mshA	575655	p.Val103Ala	missense_variant	0.39	isoniazid
mshA	575655	p.Val103Ala	missense_variant	0.39	ethionamide
mshA	575662	c.315C>G	synonymous_variant	0.34	isoniazid
mshA	575662	c.315C>G	synonymous_variant	0.34	ethionamide
mshA	575665	c.318G>T	synonymous_variant	0.37	isoniazid	Not assoc w R - Interim
mshA	575665	c.318G>T	synonymous_variant	0.37	ethionamide
mshA	575674	c.327G>C	synonymous_variant	0.34	isoniazid
mshA	575674	c.327G>C	synonymous_variant	0.34	ethionamide
mshA	575686	c.339G>C	synonymous_variant	0.31	isoniazid
mshA	575686	c.339G>C	synonymous_variant	0.31	ethionamide
mshA	575695	c.348C>G	synonymous_variant	0.34	isoniazid	Not assoc w R - Interim
mshA	575695	c.348C>G	synonymous_variant	0.34	ethionamide
mshA	575806	c.459G>C	synonymous_variant	0.3	isoniazid
mshA	575806	c.459G>C	synonymous_variant	0.3	ethionamide
mshA	575809	c.462C>T	synonymous_variant	0.38	isoniazid
mshA	575809	c.462C>T	synonymous_variant	0.38	ethionamide
mshA	575816	c.469C>T	synonymous_variant	0.46	isoniazid
mshA	575816	c.469C>T	synonymous_variant	0.46	ethionamide
mshA	575821	c.474G>C	synonymous_variant	0.48	isoniazid
mshA	575821	c.474G>C	synonymous_variant	0.48	ethionamide
mshA	575828	p.Val161Ile	missense_variant	0.55	isoniazid
mshA	575828	p.Val161Ile	missense_variant	0.55	ethionamide
mshA	575839	c.492G>C	synonymous_variant	0.61	isoniazid
mshA	575839	c.492G>C	synonymous_variant	0.61	ethionamide
mshA	575842	c.495G>C	synonymous_variant	0.59	isoniazid
mshA	575842	c.495G>C	synonymous_variant	0.59	ethionamide
mshA	575845	c.498C>A	synonymous_variant	0.59	isoniazid
mshA	575845	c.498C>A	synonymous_variant	0.59	ethionamide
mshA	575851	c.504C>T	synonymous_variant	0.6	isoniazid	Not assoc w R - Interim
mshA	575851	c.504C>T	synonymous_variant	0.6	ethionamide	Not assoc w R - Interim
mshA	575872	c.525C>T	synonymous_variant	0.58	isoniazid
mshA	575872	c.525C>T	synonymous_variant	0.58	ethionamide
mshA	575878	c.531A>G	synonymous_variant	0.56	isoniazid
mshA	575878	c.531A>G	synonymous_variant	0.56	ethionamide
mshA	575893	c.546C>G	synonymous_variant	0.6	isoniazid
mshA	575893	c.546C>G	synonymous_variant	0.6	ethionamide
mshA	575905	c.558G>C	synonymous_variant	0.53	isoniazid
mshA	575905	c.558G>C	synonymous_variant	0.53	ethionamide
mshA	575908	c.561A>G	synonymous_variant	0.52	isoniazid
mshA	575908	c.561A>G	synonymous_variant	0.52	ethionamide
mshA	575916	p.Asp190Ala	missense_variant	0.44	isoniazid
mshA	575916	p.Asp190Ala	missense_variant	0.44	ethionamide
mshA	575924	p.Gly193Ile	missense_variant	0.3	isoniazid
mshA	575924	p.Gly193Ile	missense_variant	0.3	ethionamide
mshA	575939	c.592C>T	synonymous_variant	0.38	isoniazid
mshA	575939	c.592C>T	synonymous_variant	0.38	ethionamide
mshA	575944	c.597T>C	synonymous_variant	0.38	isoniazid
mshA	575944	c.597T>C	synonymous_variant	0.38	ethionamide
mshA	575950	c.603C>G	synonymous_variant	0.35	isoniazid
mshA	575950	c.603C>G	synonymous_variant	0.35	ethionamide
mshA	575953	c.606G>C	synonymous_variant	0.38	isoniazid
mshA	575953	c.606G>C	synonymous_variant	0.38	ethionamide
mshA	575956	c.609G>A	synonymous_variant	0.4	isoniazid
mshA	575956	c.609G>A	synonymous_variant	0.4	ethionamide
mshA	576247	c.900A>G	synonymous_variant	0.32	isoniazid
mshA	576247	c.900A>G	synonymous_variant	0.32	ethionamide
ccsA	620245	p.Leu119Met	missense_variant	0.41	kanamycin
					capreomycin
					amikacin
ccsA	620253	c.363G>C	synonymous_variant	0.41	kanamycin
					capreomycin
					amikacin
ccsA	620256	c.366C>G	synonymous_variant	0.41	kanamycin
					capreomycin
					amikacin
ccsA	620265	c.375C>T	synonymous_variant	0.36	kanamycin
					capreomycin
					amikacin
ccsA	620268	c.378G>C	synonymous_variant	0.35	kanamycin
					capreomycin
					amikacin
ccsA	620271	c.381C>G	synonymous_variant	0.35	kanamycin
					capreomycin
					amikacin
ccsA	620283	c.393T>C	synonymous_variant	0.38	kanamycin
					capreomycin
					amikacin
ccsA	620284	p.Ala132Pro	missense_variant	0.38	kanamycin
					capreomycin
					amikacin
ccsA	620288	p.Arg133Gln	missense_variant	0.4	kanamycin
					capreomycin
					amikacin
ccsA	620295	c.405G>C	synonymous_variant	0.5	kanamycin
					capreomycin
					amikacin
ccsA	620313	c.423G>C	synonymous_variant	0.36	kanamycin
					capreomycin
					amikacin
ccsA	620317	p.Val143Leu	missense_variant	0.32	kanamycin
					capreomycin
					amikacin
ccsA	620361	c.471C>T	synonymous_variant	0.46	kanamycin
					capreomycin
					amikacin
ccsA	620373	c.483C>A	synonymous_variant	0.52	kanamycin
					capreomycin
					amikacin
ccsA	620388	c.498A>G	synonymous_variant	0.58	kanamycin
					capreomycin
					amikacin
ccsA	620412	c.522T>C	synonymous_variant	0.5	kanamycin
					capreomycin
					amikacin
ccsA	620415	c.525T>C	synonymous_variant	0.5	kanamycin	Not assoc w R - Interim
					capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
ccsA	620418	c.528G>A	synonymous_variant	0.48	kanamycin	Not assoc w R - Interim
					capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
ccsA	620421	c.531G>T	synonymous_variant	0.5	kanamycin
					capreomycin
					amikacin
ccsA	620433	c.543C>G	synonymous_variant	0.53	kanamycin	Not assoc w R - Interim
					capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
ccsA	620436	c.546T>C	synonymous_variant	0.52	kanamycin
					capreomycin
					amikacin
ccsA	620439	c.549T>A	synonymous_variant	0.52	kanamycin
					capreomycin
					amikacin
ccsA	620445	c.555A>G	synonymous_variant	0.5	kanamycin
					capreomycin
					amikacin
ccsA	620449	p.Leu187Met	missense_variant	0.5	kanamycin
					capreomycin
					amikacin
ccsA	620460	c.570T>C	synonymous_variant	0.38	kanamycin
					capreomycin
					amikacin
ccsA	620461	p.Val191Ile	missense_variant	0.39	kanamycin
					capreomycin
					amikacin
ccsA	620652	c.762C>G	synonymous_variant	0.45	kanamycin
					capreomycin
					amikacin
ccsA	620670	c.780C>A	synonymous_variant	0.48	kanamycin
					capreomycin
					amikacin
ccsA	620685	c.795G>A	synonymous_variant	0.54	kanamycin	Not assoc w R - Interim
					capreomycin	Not assoc w R - Interim
					amikacin
ccsA	620698	p.Val270Ile	missense_variant	0.56	kanamycin
					capreomycin
					amikacin
ccsA	620718	c.828G>C	synonymous_variant	0.66	kanamycin
					capreomycin
					amikacin
ccsA	620721	c.831G>C	synonymous_variant	0.68	kanamycin
					capreomycin
					amikacin
ccsA	620733	c.843G>C	synonymous_variant	0.77	kanamycin
					capreomycin
					amikacin
ccsA	620734	c.844C>A	synonymous_variant	0.74	kanamycin
					capreomycin
					amikacin
ccsA	620742	c.852G>C	synonymous_variant	0.71	kanamycin
					capreomycin
					amikacin
ccsA	620757	c.867C>T	synonymous_variant	0.62	kanamycin
					capreomycin
					amikacin
ccsA	620778	c.888T>C	synonymous_variant	0.59	kanamycin
					capreomycin
					amikacin
ccsA	620787	c.897C>G	synonymous_variant	0.59	kanamycin
					capreomycin
					amikacin
ccsA	620793	c.903G>C	synonymous_variant	0.65	kanamycin
					capreomycin
					amikacin
ccsA	620808	c.918T>C	synonymous_variant	0.52	kanamycin	Not assoc w R - Interim
					capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
ccsA	620832	c.942C>G	synonymous_variant	0.42	kanamycin
					capreomycin
					amikacin
Rv0565c	656085	c.1386A>G	synonymous_variant	0.41	ethionamide
Rv0565c	656088	c.1383A>G	synonymous_variant	0.39	ethionamide
Rv0565c	656091	c.1380T>C	synonymous_variant	0.39	ethionamide
Rv0565c	656109	c.1362C>T	synonymous_variant	0.5	ethionamide
Rv0565c	656112	c.1359C>G	synonymous_variant	0.5	ethionamide
Rv0565c	656129	p.Tyr448His	missense_variant	0.5	ethionamide
Rv0565c	656131	p.Pro447Leu	missense_variant	0.5	ethionamide
Rv0565c	656133	c.1338G>A	synonymous_variant	0.45	ethionamide
Rv0565c	656142	c.1329G>C	synonymous_variant	0.48	ethionamide
Rv0565c	656148	c.1323C>A	synonymous_variant	0.5	ethionamide
Rv0565c	656168	p.Ser435Ala	missense_variant	0.48	ethionamide	Uncertain significance
Rv0565c	656172	c.1299A>G	synonymous_variant	0.45	ethionamide
Rv0565c	656448	c.1023T>C	synonymous_variant	0.62	ethionamide
Rv0565c	656454	c.1017G>C	synonymous_variant	0.59	ethionamide
Rv0565c	656457	c.1014T>C	synonymous_variant	0.59	ethionamide
Rv0565c	656468	p.Gly335Arg	missense_variant	0.59	ethionamide
Rv0565c	656469	c.1002T>G	synonymous_variant	0.59	ethionamide
Rv0565c	656478	c.993C>G	synonymous_variant	0.47	ethionamide
Rv0565c	656481	c.990A>C	synonymous_variant	0.39	ethionamide
Rv0565c	656484	c.987T>C	synonymous_variant	0.39	ethionamide
Rv0565c	656487	c.984T>C	synonymous_variant	0.39	ethionamide	Not assoc w R - Interim
Rv0565c	656511	c.960T>C	synonymous_variant	0.4	ethionamide	Not assoc w R - Interim
Rv0565c	656523	c.948G>A	synonymous_variant	0.36	ethionamide
Rv0565c	656924	p.Ile183Val	missense_variant	0.36	ethionamide
Rv0565c	656926	p.Lys182Thr	missense_variant	0.38	ethionamide
Rv0565c	656946	c.525T>C	synonymous_variant	0.38	ethionamide
Rv0565c	656949	c.522G>A	synonymous_variant	0.38	ethionamide
Rv0565c	656952	c.519A>C	synonymous_variant	0.4	ethionamide	Not assoc w R - Interim
Rv0565c	656964	c.507C>G	synonymous_variant	0.41	ethionamide
Rv0565c	656973	p.Val166Ile	missense_variant	0.42	ethionamide
Rv0565c	656978	p.Ala165Thr	missense_variant	0.42	ethionamide
Rv0565c	656985	c.486T>C	synonymous_variant	0.44	ethionamide
Rv0565c	656990	p.Lys161Gln	missense_variant	0.44	ethionamide
Rv0565c	657000	p.Gly157Pro	missense_variant	0.37	ethionamide
Rv0565c	657201	c.270C>G	synonymous_variant	0.35	ethionamide
Rv0565c	657219	p.Ala84Glu	missense_variant	0.41	ethionamide
Rv0565c	657233	p.Ile80Val	missense_variant	0.44	ethionamide
Rv0565c	657237	c.234A>G	synonymous_variant	0.46	ethionamide
Rv0565c	657259	p.Tyr71Phe	missense_variant	0.54	ethionamide
Rv0565c	657261	c.210C>G	synonymous_variant	0.54	ethionamide
Rv0565c	657267	c.202_204delTCGinsAGC	synonymous_variant	0.53	ethionamide
Rv0565c	657270	c.201G>C	synonymous_variant	0.51	ethionamide
Rv0565c	657291	c.180C>G	synonymous_variant	0.53	ethionamide
Rv0565c	657300	c.171C>A	synonymous_variant	0.48	ethionamide
Rv0565c	657309	c.162C>A	synonymous_variant	0.43	ethionamide
Rv0565c	657318	c.153T>C	synonymous_variant	0.38	ethionamide
Rv0565c	657578	c.-108T>C	upstream_gene_variant	1.0	ethionamide
Rv0565c	657626	c.-156C>T	upstream_gene_variant	0.3	ethionamide
Rv0565c	657641	c.-171C>G	upstream_gene_variant	0.35	ethionamide
Rv0565c	657647	c.-177C>T	upstream_gene_variant	0.33	ethionamide
Rv0565c	657650	c.-180G>A	upstream_gene_variant	0.38	ethionamide
Rv0565c	657668	c.-198C>G	upstream_gene_variant	0.46	ethionamide
Rv0565c	657671	c.-201A>G	upstream_gene_variant	0.48	ethionamide
Rv0565c	657701	c.-231C>G	upstream_gene_variant	0.62	ethionamide
Rv0565c	657704	c.-234G>A	upstream_gene_variant	0.61	ethionamide
Rv0565c	657734	c.-264T>C	upstream_gene_variant	0.63	ethionamide
hadA	731747	c.-183T>C	upstream_gene_variant	0.52	isoniazid
hadA	731753	c.-177A>G	upstream_gene_variant	0.52	isoniazid
hadA	731774	c.-156T>C	upstream_gene_variant	0.61	isoniazid
hadA	731789	c.-141A>G	upstream_gene_variant	0.67	isoniazid
hadA	731804	c.-126C>T	upstream_gene_variant	0.64	isoniazid
hadA	731816	c.-114G>T	upstream_gene_variant	0.62	isoniazid
hadA	731819	c.-111G>T	upstream_gene_variant	0.62	isoniazid
hadA	731843	c.-87T>C	upstream_gene_variant	0.56	isoniazid
hadA	732238	c.309G>C	synonymous_variant	0.8	isoniazid
hadA	732251	p.Tyr108His	missense_variant	0.8	isoniazid
hadA	732260	p.Ser111Ala	missense_variant	0.86	isoniazid	Uncertain significance
hadA	732268	c.339T>C	synonymous_variant	0.87	isoniazid	Not assoc w R - Interim
nusG	734116	c.-138T>C	upstream_gene_variant	0.75	rifampicin	Not assoc w R
nusG	734120	c.-134T>C	upstream_gene_variant	0.28	rifampicin	Uncertain significance
nusG	734129	c.-125G>C	upstream_gene_variant	0.3	rifampicin
nusG	734143	c.-111_-110delCGinsTC	upstream_gene_variant	0.3	rifampicin
nusG	734147	c.-107T>C	upstream_gene_variant	0.29	rifampicin
nusG	734150	c.-104G>C	upstream_gene_variant	0.29	rifampicin
nusG	734171	c.-83C>A	upstream_gene_variant	0.29	rifampicin
nusG	734173	c.-81_-80delCCinsGG	upstream_gene_variant	0.3	rifampicin
nusG	734177	c.-77T>C	upstream_gene_variant	0.3	rifampicin
nusG	734180	c.-74T>C	upstream_gene_variant	0.3	rifampicin
nusG	734194	c.-60C>G	upstream_gene_variant	0.54	rifampicin
nusG	734201	c.-53G>C	upstream_gene_variant	0.56	rifampicin
nusG	734205	c.-49A>C	upstream_gene_variant	0.53	rifampicin
nusG	734224	c.-30G>A	upstream_gene_variant	0.47	rifampicin	Uncertain significance
nusG	734227	c.-27C>T	upstream_gene_variant	0.47	rifampicin
nusG	734233	c.-21T>C	upstream_gene_variant	0.47	rifampicin
nusG	734236	c.-18C>T	upstream_gene_variant	0.43	rifampicin
nusG	734249	c.-5A>G	upstream_gene_variant	0.48	rifampicin
nusG	734259	c.6T>G	synonymous_variant	0.48	rifampicin
nusG	734262	c.9C>G	synonymous_variant	0.52	rifampicin
nusG	734283	c.30G>A	synonymous_variant	0.33	rifampicin
nusG	734346	c.93G>A	synonymous_variant	0.69	rifampicin
nusG	734352	c.99T>C	synonymous_variant	0.69	rifampicin
nusG	734355	c.102G>C	synonymous_variant	0.69	rifampicin
nusG	734361	c.108C>T	synonymous_variant	0.7	rifampicin
nusG	734370	c.117A>G	synonymous_variant	0.73	rifampicin
nusG	734403	c.150C>T	synonymous_variant	0.77	rifampicin
nusG	734407	p.Val52Ile	missense_variant	0.79	rifampicin
nusG	734418	c.165C>T	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
nusG	734421	c.168A>G	synonymous_variant	0.71	rifampicin
nusG	734424	c.171G>A	synonymous_variant	0.72	rifampicin
nusG	734439	c.186C>G	synonymous_variant	0.73	rifampicin
nusG	734451	c.198G>C	synonymous_variant	0.67	rifampicin
nusG	734454	c.201A>G	synonymous_variant	0.65	rifampicin
nusG	734460	c.207G>T	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
nusG	734505	c.252G>T	synonymous_variant	0.62	rifampicin
nusG	734532	c.279A>G	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
nusG	734541	c.288A>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
nusG	734553	c.300C>G	synonymous_variant	0.7	rifampicin
nusG	734556	c.303C>T	synonymous_variant	0.7	rifampicin
nusG	734559	c.306T>C	synonymous_variant	0.7	rifampicin
nusG	734571	c.318C>G	synonymous_variant	0.72	rifampicin
nusG	734580	c.327T>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
nusG	734589	c.336G>C	synonymous_variant	0.7	rifampicin
nusG	734610	c.357C>G	synonymous_variant	0.78	rifampicin
nusG	734614	p.Ala121Ser	missense_variant	0.76	rifampicin
nusG	734625	c.372T>C	synonymous_variant	0.56	rifampicin
nusG	734829	c.576C>G	synonymous_variant	0.34	rifampicin	Not assoc w R - Interim
nusG	734847	c.594T>C	synonymous_variant	0.43	rifampicin
nusG	734850	c.597C>G	synonymous_variant	0.44	rifampicin
nusG	734853	c.600A>C	synonymous_variant	0.47	rifampicin
nusG	734870	p.Ser206Asn	missense_variant	0.51	rifampicin
nusG	734895	c.642A>G	synonymous_variant	0.53	rifampicin
nusG	734913	c.660C>G	synonymous_variant	0.46	rifampicin
nusG	734928	c.675A>G	synonymous_variant	0.41	rifampicin
nusG	734931	c.678A>G	synonymous_variant	0.37	rifampicin
nusG	734937	c.684G>C	synonymous_variant	0.33	rifampicin
mmaA3	737964	p.Thr62Ala	missense_variant	0.55	isoniazid
mmaA3	737967	c.183A>G	synonymous_variant	0.57	isoniazid
mmaA3	737988	c.162A>C	synonymous_variant	0.67	isoniazid
mmaA3	737993	p.Glu53Gln	missense_variant	0.65	isoniazid
mmaA3	737994	p.His52Glu	missense_variant	0.65	isoniazid
mmaA3	737999	c.151T>C	synonymous_variant	0.68	isoniazid
mmaA3	738000	c.150C>G	synonymous_variant	0.65	isoniazid
mmaA3	738021	c.129C>T	synonymous_variant	0.47	isoniazid
mmaA3	738036	c.114C>G	synonymous_variant	0.44	isoniazid
mmaA3	738042	c.108T>C	synonymous_variant	0.44	isoniazid
mmaA3	738048	c.102T>C	synonymous_variant	0.38	isoniazid
rpoB	760091	c.285G>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoB	760101	c.295T>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoB	760112	c.306T>C	synonymous_variant	0.55	rifampicin
rpoB	760118	c.312T>C	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoB	760121	c.315T>C	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoB	760130	p.Asp108Glu	missense_variant	0.56	rifampicin	Uncertain significance
rpoB	760139	c.333A>G	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoB	760142	c.336C>G	synonymous_variant	0.6	rifampicin
rpoB	760181	c.375T>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoB	760184	c.378A>G	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	760196	c.390C>G	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	760235	c.429T>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	760298	c.492G>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoB	760310	c.504G>C	synonymous_variant	0.9	rifampicin
rpoB	760313	c.507G>C	synonymous_variant	0.9	rifampicin
rpoB	760328	c.522G>C	synonymous_variant	0.9	rifampicin
rpoB	760331	c.525G>C	synonymous_variant	0.85	rifampicin
rpoB	760340	c.534G>C	synonymous_variant	0.83	rifampicin
rpoB	760358	c.552C>G	synonymous_variant	0.81	rifampicin
rpoB	760361	c.555T>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	760376	p.Asp190Glu	missense_variant	0.74	rifampicin	Uncertain significance
rpoB	760406	c.600G>C	synonymous_variant	0.69	rifampicin
rpoB	760424	c.618C>G	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoB	760430	c.624T>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	760451	c.645C>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	760457	c.651C>T	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	760463	c.657C>T	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	760475	c.669A>G	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	760481	c.675G>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoB	760484	c.678A>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	760487	c.681G>C	synonymous_variant	0.66	rifampicin
rpoB	760508	c.702G>C	synonymous_variant	0.66	rifampicin
rpoB	760511	c.705G>C	synonymous_variant	0.61	rifampicin
rpoB	760514	c.708C>G	synonymous_variant	0.62	rifampicin
rpoB	760522	p.Ser239Asn	missense_variant	0.65	rifampicin	Uncertain significance
rpoB	760532	c.726T>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoB	760533	p.Val243His	missense_variant	0.65	rifampicin
rpoB	760547	c.741G>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoB	760561	c.757_758delCG	frameshift_variant	0.64	rifampicin
rpoB	760567	p.Ser254Trp	missense_variant	0.67	rifampicin
rpoB	760568	c.762_763insGC	frameshift_variant	0.67	rifampicin
rpoB	760571	c.765G>C	synonymous_variant	0.7	rifampicin
rpoB	760591	p.Val262Ala	missense_variant	0.82	rifampicin
rpoB	760611	c.805T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoB	760643	c.837G>A	synonymous_variant	0.74	rifampicin
rpoB	760646	c.840C>G	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoB	760655	c.849A>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	760661	c.855A>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoB	760670	c.864G>C	synonymous_variant	0.72	rifampicin
rpoB	760674	c.868T>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoB	760679	c.873A>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	760683	c.877T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoB	760718	c.912C>T	synonymous_variant	0.67	rifampicin
rpoB	760724	c.918T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoB	760730	c.924T>C	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoB	760748	c.942C>G	synonymous_variant	0.6	rifampicin
rpoB	760751	c.945G>C	synonymous_variant	0.56	rifampicin
rpoB	760766	p.Glu320Asp	missense_variant	0.5	rifampicin	Uncertain significance
rpoB	760769	c.963C>G	synonymous_variant	0.5	rifampicin
rpoB	760775	c.969G>C	synonymous_variant	0.5	rifampicin
rpoB	760776	c.970_972delTCGinsAGC	synonymous_variant	0.5	rifampicin
rpoB	760830	c.1024_1026delTTGinsCTC	synonymous_variant	0.4	rifampicin
rpoB	760845	p.Thr347His	missense_variant	0.35	rifampicin
rpoB	760868	c.1062C>G	synonymous_variant	0.41	rifampicin
rpoB	760869	p.Val355Thr	missense_variant	0.41	rifampicin
rpoB	760877	c.1071G>T	synonymous_variant	0.46	rifampicin
rpoB	760886	c.1080A>G	synonymous_variant	0.61	rifampicin
rpoB	760919	c.1113C>G	synonymous_variant	0.7	rifampicin
rpoB	760925	c.1119T>C	synonymous_variant	0.71	rifampicin
rpoB	760928	c.1122G>C	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoB	760931	c.1125C>G	synonymous_variant	0.72	rifampicin
rpoB	760946	c.1140A>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	760970	c.1164G>C	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoB	760982	c.1176G>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	760985	c.1179G>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoB	760988	c.1182C>G	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoB	760991	c.1185G>C	synonymous_variant	0.68	rifampicin
rpoB	761006	c.1200C>T	synonymous_variant	0.71	rifampicin
rpoB	761015	c.1209G>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoB	761021	c.1215G>C	synonymous_variant	0.67	rifampicin
rpoB	761027	c.1221A>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	761036	c.1230G>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	761037	c.1231T>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	761057	c.1251G>C	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoB	761096	c.1290G>C	synonymous_variant	0.46	rifampicin
rpoB	761097	c.1291_1293delAGCinsTCG	synonymous_variant	0.43	rifampicin
rpoB	761102	c.1296A>G	synonymous_variant	0.45	rifampicin
rpoB	761132	c.1326G>T	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoB	761133	c.1327T>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoB	761147	c.1341C>T	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoB	761150	c.1344A>T	synonymous_variant	0.45	rifampicin	Not assoc w R - Interim
rpoB	761168	c.1362C>G	synonymous_variant	0.44	rifampicin
rpoB	761171	c.1365C>T	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoB	761180	c.1374A>C	synonymous_variant	0.37	rifampicin	Not assoc w R - Interim
rpoB	761192	c.1386C>G	synonymous_variant	0.35	rifampicin
rpoB	761195	c.1389G>T	synonymous_variant	0.35	rifampicin
rpoB	761201	c.1395G>A	synonymous_variant	0.36	rifampicin
rpoB	761204	c.1398C>A	synonymous_variant	0.34	rifampicin
rpoB	761207	c.1401C>T	synonymous_variant	0.34	rifampicin
rpoB	761234	c.1428G>C	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoB	761249	c.1443A>G	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoB	761252	c.1446C>G	synonymous_variant	0.48	rifampicin
rpoB	761255	c.1449T>G	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoB	761258	c.1452G>A	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoB	761261	c.1455G>C	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoB	761264	c.1458C>G	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoB	761273	c.1467T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	761282	c.1476C>T	synonymous_variant	0.58	rifampicin
rpoB	761414	c.1608A>G	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	761423	c.1617T>C	synonymous_variant	0.27	rifampicin
rpoB	761435	c.1629T>C	synonymous_variant	0.26	rifampicin
rpoB	761437	p.Ala544Glu	missense_variant	0.26	rifampicin
rpoB	761439	p.Asp545Asn	missense_variant	0.24	rifampicin
rpoB	761444	c.1638T>C	synonymous_variant	0.28	rifampicin
rpoB	761447	c.1641C>G	synonymous_variant	0.28	rifampicin
rpoB	761450	c.1644C>T	synonymous_variant	0.29	rifampicin
rpoB	761452	p.Val549Ala	missense_variant	0.29	rifampicin
rpoB	761465	c.1659G>T	synonymous_variant	0.44	rifampicin
rpoB	761510	c.1704T>C	synonymous_variant	0.44	rifampicin
rpoB	761537	c.1731C>G	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoB	761573	c.1767C>G	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoB	761579	c.1773G>C	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoB	761582	c.1776G>A	synonymous_variant	0.6	rifampicin
rpoB	761606	c.1800C>G	synonymous_variant	0.7	rifampicin
rpoB	761612	c.1806G>T	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoB	761615	c.1809A>C	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoB	761636	c.1830G>T	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoB	761645	c.1839C>G	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	761648	c.1842T>C	synonymous_variant	0.81	rifampicin
rpoB	761657	c.1851C>A	synonymous_variant	0.81	rifampicin
rpoB	761675	c.1869G>C	synonymous_variant	0.78	rifampicin
rpoB	761682	c.1876C>T	synonymous_variant	0.78	rifampicin
rpoB	761687	c.1881C>T	synonymous_variant	0.77	rifampicin
rpoB	761717	c.1911C>G	synonymous_variant	0.7	rifampicin
rpoB	761726	c.1920A>G	synonymous_variant	0.63	rifampicin
rpoB	761727	p.Ser641Ala	missense_variant	0.61	rifampicin
rpoB	761732	c.1926C>T	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	761741	c.1935G>A	synonymous_variant	0.64	rifampicin
rpoB	761753	c.1947C>G	synonymous_variant	0.68	rifampicin
rpoB	761765	c.1959T>C	synonymous_variant	0.65	rifampicin
rpoB	761768	c.1962G>C	synonymous_variant	0.65	rifampicin
rpoB	761778	p.Asn658Ala	missense_variant	0.61	rifampicin
rpoB	761792	c.1986T>C	synonymous_variant	0.56	rifampicin
rpoB	761813	c.2007T>C	synonymous_variant	0.52	rifampicin
rpoB	761819	c.2013G>C	synonymous_variant	0.52	rifampicin
rpoB	761834	c.2028T>C	synonymous_variant	0.48	rifampicin
rpoB	761885	c.2079T>C	synonymous_variant	0.33	rifampicin
rpoB	761894	c.2088C>T	synonymous_variant	0.34	rifampicin
rpoB	761903	c.2097T>C	synonymous_variant	0.32	rifampicin
rpoB	761909	c.2103T>C	synonymous_variant	0.27	rifampicin
rpoB	761912	c.2106T>C	synonymous_variant	0.26	rifampicin
rpoB	761915	p.Asp703Glu	missense_variant	0.26	rifampicin
rpoB	761916	p.Asp704Asn	missense_variant	0.28	rifampicin
rpoB	761921	c.2115C>T	synonymous_variant	0.29	rifampicin
rpoB	761930	c.2124G>C	synonymous_variant	0.29	rifampicin
rpoB	761955	p.Ile717Val	missense_variant	0.33	rifampicin	Uncertain significance
rpoB	761972	c.2166C>T	synonymous_variant	0.37	rifampicin	Not assoc w R - Interim
rpoB	761990	c.2184G>C	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoB	762011	c.2205G>C	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoB	762029	c.2223C>G	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	762032	c.2226C>T	synonymous_variant	0.6	rifampicin
rpoB	762038	c.2232C>T	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	762053	c.2247T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	762056	c.2250G>A	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	762062	c.2256T>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	762065	c.2259T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	762086	c.2280G>C	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoB	762114	p.Ile770Val	missense_variant	0.27	rifampicin	Uncertain significance
rpoB	762131	c.2325C>G	synonymous_variant	0.39	rifampicin
rpoB	762134	c.2328C>G	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoB	762143	c.2337T>C	synonymous_variant	0.55	rifampicin
rpoB	762149	c.2343G>T	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	762167	c.2361T>C	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoB	762170	c.2364C>G	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoB	762179	c.2373C>T	synonymous_variant	0.61	rifampicin
rpoB	762185	c.2379G>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	762212	c.2406G>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoB	762233	c.2427G>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	762254	c.2448T>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	762260	c.2454C>T	synonymous_variant	0.67	rifampicin
rpoB	762266	c.2460T>C	synonymous_variant	0.65	rifampicin
rpoB	762284	c.2478G>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoB	762293	c.2487T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	762296	c.2490G>A	synonymous_variant	0.53	rifampicin
rpoB	762753	c.2947T>C	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoC	762758	c.-612G>C	upstream_gene_variant	0.57	rifampicin
rpoB	762782	c.2976T>C	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoB	762789	p.Leu995Met	missense_variant	0.68	rifampicin	Uncertain significance
rpoB	762795	p.Asp997Asn	missense_variant	0.7	rifampicin	Uncertain significance
rpoB	762799	p.Ala998Gly	missense_variant	0.72	rifampicin	Uncertain significance
rpoB	762813	p.Met1003Val	missense_variant	0.68	rifampicin
rpoB	762818	c.3012C>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	762857	c.3051C>G	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>T	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	762956	c.-414G>C	upstream_gene_variant	0.62	rifampicin
rpoB	762959	c.3153G>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	762962	c.3156C>T	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	762971	c.3165G>A	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
rpoC	762983	c.-387C>G	upstream_gene_variant	0.61	rifampicin
rpoB	762995	c.3189G>T	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	763031	c.3225T>C	synonymous_variant	0.41	rifampicin	Not assoc w R
rpoB	763031	c.3225T>G	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoB	763040	c.3234C>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	763053	c.3247T>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	763070	c.3264T>C	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoB	763082	c.3276C>T	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	763085	c.3279C>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	763094	c.3288G>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoB	763115	c.3309T>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoB	763127	c.3321G>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	763139	c.-231C>T	upstream_gene_variant	0.67	rifampicin
rpoC	763142	c.-228C>G	upstream_gene_variant	0.69	rifampicin
rpoB	763166	c.3360A>G	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	763169	c.-201A>G	upstream_gene_variant	0.68	rifampicin
rpoC	763190	c.-180C>T	upstream_gene_variant	0.63	rifampicin
rpoC	763193	c.-177C>T	upstream_gene_variant	0.62	rifampicin
rpoC	763202	c.-168A>G	upstream_gene_variant	0.62	rifampicin
rpoC	763206	c.-164_-162delAGTinsTCG	upstream_gene_variant	0.62	rifampicin
rpoC	763220	c.-150G>C	upstream_gene_variant	0.45	rifampicin
rpoC	763226	c.-144A>G	upstream_gene_variant	0.43	rifampicin
rpoC	763373	c.4_6delCTCinsTTA	synonymous_variant	0.5	rifampicin
rpoC	763402	c.33C>A	synonymous_variant	0.44	rifampicin
rpoC	763408	c.39T>C	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoC	763411	c.42T>G	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoC	763414	c.45T>G	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoC	763430	c.61_63delAGGinsCGT	synonymous_variant	0.48	rifampicin
rpoC	763435	c.66A>G	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoC	763444	c.75T>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoC	763456	c.87A>G	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	763468	c.99G>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoC	763483	c.114G>C	synonymous_variant	0.6	rifampicin
rpoC	763486	c.117T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoC	763492	c.123G>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoC	763504	c.135C>T	synonymous_variant	0.6	rifampicin
rpoC	763528	c.159G>A	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	763546	c.177A>G	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	763570	c.201G>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	763594	c.225C>T	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	763603	c.234C>T	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	763615	c.246G>C	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
rpoC	763618	c.249C>T	synonymous_variant	0.84	rifampicin
rpoC	763624	c.255C>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	763648	c.279C>G	synonymous_variant	0.64	rifampicin
rpoC	763660	c.291T>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	763666	c.297G>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	763669	c.300C>G	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	763696	c.327T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoC	763699	c.330G>C	synonymous_variant	0.55	rifampicin
rpoC	763702	c.333C>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	763709	c.340C>T	synonymous_variant	0.55	rifampicin
rpoC	763714	c.345G>C	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoC	763717	c.348T>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoC	763732	c.363C>G	synonymous_variant	0.65	rifampicin
rpoC	763735	c.366G>C	synonymous_variant	0.64	rifampicin
rpoC	763765	c.396T>C	synonymous_variant	0.6	rifampicin
rpoC	763768	c.399C>G	synonymous_variant	0.6	rifampicin
rpoC	763781	p.Ser138Ala	missense_variant	0.58	rifampicin
rpoC	763792	p.Glu141Asp	missense_variant	0.58	rifampicin
rpoC	763807	c.438T>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoC	763816	c.447C>G	synonymous_variant	0.47	rifampicin
rpoC	763822	c.453C>G	synonymous_variant	0.41	rifampicin
rpoC	763825	c.456G>A	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
rpoC	763828	c.459C>G	synonymous_variant	0.43	rifampicin
rpoC	763836	p.Ala156Val	missense_variant	0.47	rifampicin
rpoC	763858	c.489A>G	synonymous_variant	0.39	rifampicin
rpoC	763872	p.Gly168Ala	missense_variant	0.32	rifampicin
rpoC	763884	p.Ala172Val	missense_variant	0.62	rifampicin	Not assoc w R
rpoC	763886	p.Arg173Ser	missense_variant	0.62	rifampicin
rpoC	763891	c.522G>C	synonymous_variant	0.29	rifampicin
rpoC	763894	c.525A>G	synonymous_variant	0.29	rifampicin
rpoC	763900	c.531G>C	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoC	763987	c.618C>T	synonymous_variant	0.5	rifampicin
rpoC	763991	p.Ile208Leu	missense_variant	0.46	rifampicin
rpoC	763996	c.627T>C	synonymous_variant	0.52	rifampicin
rpoC	764024	c.655_657delTTGinsCTC	synonymous_variant	0.4	rifampicin
rpoC	764044	c.675T>C	synonymous_variant	0.37	rifampicin
rpoC	764059	c.690G>C	synonymous_variant	0.43	rifampicin
rpoC	764077	c.708C>G	synonymous_variant	0.45	rifampicin
rpoC	764083	c.714A>G	synonymous_variant	0.46	rifampicin
rpoC	764098	c.729A>G	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoC	764101	c.732C>G	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoC	764102	p.Val245Gln	missense_variant	0.43	rifampicin
rpoC	764113	c.744C>T	synonymous_variant	0.44	rifampicin
rpoC	764159	c.790C>T	synonymous_variant	0.49	rifampicin
rpoC	764188	c.819A>G	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoC	764195	p.Ser276Asn	missense_variant	0.41	rifampicin
rpoC	764203	c.834G>T	synonymous_variant	0.44	rifampicin
rpoC	764206	p.Asp279Glu	missense_variant	0.44	rifampicin
rpoC	764209	c.840C>T	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoC	764217	p.Asn283Ser	missense_variant	0.5	rifampicin
rpoC	764227	c.858G>C	synonymous_variant	0.54	rifampicin
rpoC	764245	c.876C>T	synonymous_variant	0.46	rifampicin
rpoC	764254	c.885G>T	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoC	764266	c.897T>C	synonymous_variant	0.43	rifampicin
rpoC	764269	c.900G>C	synonymous_variant	0.41	rifampicin
rpoC	764272	c.903G>T	synonymous_variant	0.43	rifampicin
rpoC	764278	c.909A>G	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoC	764302	c.933C>G	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoC	764308	c.939G>C	synonymous_variant	0.59	rifampicin
rpoC	764311	c.942C>G	synonymous_variant	0.61	rifampicin
rpoC	764326	c.957G>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoC	764338	c.969G>A	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoC	764359	c.990C>T	synonymous_variant	0.58	rifampicin
rpoC	764383	c.1014C>G	synonymous_variant	0.54	rifampicin
rpoC	764387	c.1018_1020delTTGinsCTC	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoC	764405	c.1036_1038delAGGinsCGC	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoC	764428	c.1059G>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	764431	c.1062G>C	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoC	764434	c.1065A>G	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoC	764446	c.1077T>C	synonymous_variant	0.53	rifampicin
rpoC	764449	c.1080G>C	synonymous_variant	0.53	rifampicin
rpoC	764452	c.1083T>C	synonymous_variant	0.52	rifampicin
rpoC	764458	c.1089G>C	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	764461	c.1092A>G	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoC	764497	c.1128A>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoC	764503	c.1134G>C	synonymous_variant	0.66	rifampicin
rpoC	764521	c.1152T>C	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	764527	c.1158C>T	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	764536	c.1167G>C	synonymous_variant	0.79	rifampicin
rpoC	764548	c.1179G>A	synonymous_variant	0.77	rifampicin
rpoC	764566	c.1197C>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	764575	c.1206T>G	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoC	764581	c.1212T>C	synonymous_variant	0.82	rifampicin
rpoC	764611	c.1242G>C	synonymous_variant	0.83	rifampicin
rpoC	764650	c.1281G>T	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
rpoC	764716	c.1347G>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoC	764752	c.1383G>C	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	764764	c.1395T>C	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoC	764803	c.1434C>T	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoC	764809	c.1440C>T	synonymous_variant	0.53	rifampicin	Not assoc w R
rpoC	764812	c.1443C>G	synonymous_variant	0.51	rifampicin
rpoC	764815	c.1446A>G	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoC	764824	c.1455T>C	synonymous_variant	0.51	rifampicin	Not assoc w R - Interim
rpoC	764833	c.1464A>G	synonymous_variant	0.51	rifampicin
rpoC	764836	c.1467G>A	synonymous_variant	0.51	rifampicin
rpoC	764842	c.1473C>T	synonymous_variant	0.51	rifampicin
rpoC	764858	c.1489T>C	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	764869	c.1500C>T	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	764875	c.1506C>G	synonymous_variant	0.71	rifampicin
rpoC	764893	c.1524T>C	synonymous_variant	0.68	rifampicin
rpoC	764896	c.1527C>T	synonymous_variant	0.67	rifampicin
rpoC	764911	c.1542A>G	synonymous_variant	0.78	rifampicin
rpoC	764968	c.1599T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	765007	c.1638T>G	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoC	765016	c.1647C>G	synonymous_variant	0.41	rifampicin
rpoC	765019	c.1650A>G	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
rpoC	765022	c.1653G>T	synonymous_variant	0.38	rifampicin
rpoC	765171	p.Pro601Leu	missense_variant	1.0	rifampicin	Not assoc w R
rpoC	765289	c.1920G>C	synonymous_variant	0.33	rifampicin
rpoC	765292	c.1923G>T	synonymous_variant	0.31	rifampicin
rpoC	765305	p.Ile646Leu	missense_variant	0.36	rifampicin
rpoC	765319	c.1950A>G	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoC	765349	c.1980T>C	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoC	765352	c.1983G>C	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoC	765356	p.Met663Val	missense_variant	0.48	rifampicin
rpoC	765370	c.2001G>C	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoC	765383	p.Met672Leu	missense_variant	0.67	rifampicin	Uncertain significance
rpoC	765394	c.2025G>A	synonymous_variant	0.76	rifampicin
rpoC	765409	c.2040T>C	synonymous_variant	0.75	rifampicin
rpoC	765412	c.2043T>C	synonymous_variant	0.73	rifampicin
rpoC	765421	c.2052C>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	765451	c.2082C>G	synonymous_variant	0.83	rifampicin
rpoC	765454	c.2085C>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	765478	c.2109T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	765499	c.2130C>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	765508	c.2139C>G	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoC	765541	c.2172C>G	synonymous_variant	0.59	rifampicin
rpoC	765547	c.2178C>A	synonymous_variant	0.55	rifampicin
rpoC	765556	c.2187G>C	synonymous_variant	0.52	rifampicin
rpoC	765607	c.2238C>G	synonymous_variant	0.62	rifampicin
rpoC	765611	p.His748Ala	missense_variant	0.61	rifampicin
rpoC	765619	c.2250G>A	synonymous_variant	0.68	rifampicin
rpoC	765625	c.2256C>T	synonymous_variant	0.7	rifampicin
rpoC	765631	p.Asp754Glu	missense_variant	0.68	rifampicin
rpoC	765676	c.2307G>A	synonymous_variant	0.84	rifampicin
rpoC	765688	c.2319G>C	synonymous_variant	0.81	rifampicin
rpoC	765694	c.2325G>C	synonymous_variant	0.81	rifampicin
rpoC	765700	c.2331T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	765724	c.2355C>G	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	765734	c.2365T>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	765751	c.2382C>G	synonymous_variant	0.72	rifampicin
rpoC	765752	p.Asp795Ser	missense_variant	0.72	rifampicin
rpoC	765772	c.2403C>G	synonymous_variant	0.47	rifampicin
rpoC	765826	c.2457T>C	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoC	765835	c.2466C>T	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	765850	c.2481G>C	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoC	765865	c.2496C>T	synonymous_variant	0.52	rifampicin
rpoC	765871	c.2502T>C	synonymous_variant	0.57	rifampicin
rpoC	765875	p.Val836Ile	missense_variant	0.54	rifampicin	Uncertain significance
rpoC	765883	c.2514C>G	synonymous_variant	0.6	rifampicin
rpoC	765886	c.2517C>G	synonymous_variant	0.61	rifampicin
rpoC	765892	c.2523T>C	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoC	765946	c.2577C>T	synonymous_variant	0.79	rifampicin
rpoC	765961	c.2592G>A	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	765962	c.2593T>C	synonymous_variant	0.77	rifampicin
rpoC	765967	c.2598C>G	synonymous_variant	0.79	rifampicin
rpoC	765994	c.2625A>T	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	766003	c.2634G>C	synonymous_variant	0.74	rifampicin
rpoC	766009	c.2640G>C	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoC	766010	c.2641_2642delTCinsAG	synonymous_variant	0.73	rifampicin
rpoC	766069	c.2700G>A	synonymous_variant	0.6	rifampicin
rpoC	766081	c.2712T>C	synonymous_variant	0.44	rifampicin
rpoC	766082	p.Ala905Gln	missense_variant	0.44	rifampicin
rpoC	766094	p.Thr909Ser	missense_variant	0.5	rifampicin
rpoC	766105	c.2736C>T	synonymous_variant	0.49	rifampicin
rpoC	766129	c.2760C>G	synonymous_variant	0.38	rifampicin
rpoC	766135	c.2766G>A	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoC	766141	c.2772C>T	synonymous_variant	0.27	rifampicin
rpoC	766142	c.2773C>T	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoC	766147	c.2778C>G	synonymous_variant	0.27	rifampicin
rpoC	766148	p.Thr927Ala	missense_variant	0.27	rifampicin	Uncertain significance
rpoC	766270	c.2901G>C	synonymous_variant	0.54	rifampicin
rpoC	766273	c.2904T>C	synonymous_variant	0.54	rifampicin
rpoC	766274	p.Ala969Thr	missense_variant	0.56	rifampicin
rpoC	766280	p.Ser971Gly	missense_variant	0.59	rifampicin
rpoC	766291	c.2922G>C	synonymous_variant	0.59	rifampicin
rpoC	766297	c.2928G>C	synonymous_variant	0.68	rifampicin
rpoC	766309	c.2940G>A	synonymous_variant	0.71	rifampicin
rpoC	766312	c.2943T>G	synonymous_variant	0.7	rifampicin
rpoC	766315	c.2946C>G	synonymous_variant	0.72	rifampicin
rpoC	766342	c.2973C>T	synonymous_variant	0.73	rifampicin
rpoC	766345	c.2976T>C	synonymous_variant	0.73	rifampicin
rpoC	766348	c.2979A>G	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	766381	c.3012C>T	synonymous_variant	0.62	rifampicin
rpoC	766384	c.3015A>G	synonymous_variant	0.6	rifampicin
rpoC	766393	c.3024C>G	synonymous_variant	0.54	rifampicin
rpoC	766408	c.3039C>T	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoC	766426	c.3057C>T	synonymous_variant	0.41	rifampicin
rpoC	766429	c.3060C>G	synonymous_variant	0.43	rifampicin
rpoC	766435	c.3066G>A	synonymous_variant	0.46	rifampicin
rpoC	766447	c.3078T>C	synonymous_variant	0.49	rifampicin
rpoC	766456	c.3087C>G	synonymous_variant	0.48	rifampicin
rpoC	766459	c.3090G>T	synonymous_variant	0.52	rifampicin
rpoC	766462	c.3093G>C	synonymous_variant	0.52	rifampicin
rpoC	766480	p.Val1039Ile	missense_variant	0.59	rifampicin	Uncertain significance
rpoC	766486	c.3117A>C	synonymous_variant	0.65	rifampicin
rpoC	766495	c.3126C>G	synonymous_variant	0.71	rifampicin
rpoC	766522	c.3153C>T	synonymous_variant	0.74	rifampicin
rpoC	766525	c.3156G>T	synonymous_variant	0.71	rifampicin
rpoC	766528	c.3159T>C	synonymous_variant	0.71	rifampicin
rpoC	766549	c.3180G>C	synonymous_variant	0.72	rifampicin
rpoC	766564	c.3195C>T	synonymous_variant	0.71	rifampicin
rpoC	766565	p.Ile1066Val	missense_variant	0.71	rifampicin	Uncertain significance
rpoC	766573	c.3204T>C	synonymous_variant	0.74	rifampicin
rpoC	766585	c.3216T>C	synonymous_variant	0.73	rifampicin
rpoC	766607	p.Ile1080Leu	missense_variant	0.73	rifampicin
rpoC	766618	c.3249G>T	synonymous_variant	0.68	rifampicin
rpoC	766624	c.3255G>C	synonymous_variant	0.71	rifampicin
rpoC	766645	c.3276A>G	synonymous_variant	0.75	rifampicin
rpoC	766657	c.3288A>G	synonymous_variant	0.8	rifampicin
rpoC	766667	p.Ser1100Ala	missense_variant	0.81	rifampicin	Uncertain significance
rpoC	766672	c.3303T>C	synonymous_variant	0.81	rifampicin
rpoC	766726	c.3357T>C	synonymous_variant	0.81	rifampicin
rpoC	766738	c.3369G>C	synonymous_variant	0.76	rifampicin
rpoC	766750	c.3381C>G	synonymous_variant	0.69	rifampicin
rpoC	766753	c.3384C>T	synonymous_variant	0.69	rifampicin
rpoC	766765	c.3396A>C	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	766774	c.3405T>C	synonymous_variant	0.5	rifampicin
rpoC	766783	c.3414C>T	synonymous_variant	0.5	rifampicin
rpoC	766801	c.3432C>T	synonymous_variant	0.43	rifampicin
rpoC	766804	c.3435A>G	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoC	766843	c.3474T>G	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	766861	c.3492G>C	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoC	766864	c.3495G>C	synonymous_variant	0.58	rifampicin
rpoC	766894	c.3525T>C	synonymous_variant	0.6	rifampicin
rpoC	766895	c.3526T>C	synonymous_variant	0.6	rifampicin
rpoC	766900	c.3531T>C	synonymous_variant	0.63	rifampicin
rpoC	766903	c.3534C>T	synonymous_variant	0.67	rifampicin
rpoC	766918	c.3549C>T	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	766933	c.3564A>G	synonymous_variant	0.73	rifampicin
rpoC	766945	c.3576A>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoC	766960	c.3591C>T	synonymous_variant	0.66	rifampicin
rpoC	766963	c.3594T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	766972	c.3603G>C	synonymous_variant	0.67	rifampicin
rpoC	766996	c.3627C>T	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	767033	c.3664_3666delTCGinsAGT	synonymous_variant	0.7	rifampicin
rpoC	767059	c.3690T>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	767062	c.3693C>A	synonymous_variant	0.76	rifampicin
rpoC	767098	c.3729T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	767119	c.3750A>G	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoC	767134	c.3765C>A	synonymous_variant	0.55	rifampicin
rpoC	767152	c.3783T>G	synonymous_variant	0.54	rifampicin
rpoC	767155	c.3786C>G	synonymous_variant	0.48	rifampicin
rpoC	767167	c.3798C>T	synonymous_variant	0.47	rifampicin
rpoC	767180	p.Ala1271Gln	missense_variant	0.48	rifampicin
rpoC	767191	c.3822C>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	767206	c.3837C>G	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoC	767209	c.3840T>C	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoC	767212	c.3843G>C	synonymous_variant	0.54	rifampicin
rpoC	767233	c.3864T>C	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoC	767239	c.3870T>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	767264	p.Ala1299Gln	missense_variant	0.41	rifampicin
rpoC	767269	c.3900C>G	synonymous_variant	0.43	rifampicin
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	775904	c.2577G>A	synonymous_variant	0.22	bedaquiline
mmpL5	775904	c.2577G>A	synonymous_variant	0.22	clofazimine
mmpL5	775909	p.Leu858Phe	missense_variant	0.38	bedaquiline
mmpL5	775909	p.Leu858Phe	missense_variant	0.38	clofazimine
mmpL5	775913	p.Ala856Ser	missense_variant	0.21	bedaquiline
mmpL5	775913	p.Ala856Ser	missense_variant	0.21	clofazimine
mmpL5	775939	p.Ala848Ser	missense_variant	0.3	bedaquiline
mmpL5	775939	p.Ala848Ser	missense_variant	0.3	clofazimine
mmpL5	775943	c.2538C>G	synonymous_variant	0.23	bedaquiline
mmpL5	775943	c.2538C>G	synonymous_variant	0.23	clofazimine
mmpL5	775946	c.2535C>G	synonymous_variant	0.29	bedaquiline
mmpL5	775946	c.2535C>G	synonymous_variant	0.29	clofazimine
mmpL5	775949	c.2532G>C	synonymous_variant	0.24	bedaquiline
mmpL5	775949	c.2532G>C	synonymous_variant	0.24	clofazimine
mmpL5	775961	c.2520C>G	synonymous_variant	0.34	bedaquiline
mmpL5	775961	c.2520C>G	synonymous_variant	0.34	clofazimine
mmpL5	775966	p.Ala839Ser	missense_variant	0.32	bedaquiline
mmpL5	775966	p.Ala839Ser	missense_variant	0.32	clofazimine
rpsL	781164	c.-396T>C	upstream_gene_variant	0.38	streptomycin
rpsL	781173	c.-387A>G	upstream_gene_variant	0.41	streptomycin
rpsL	781174	c.-386C>A	upstream_gene_variant	0.43	streptomycin
rpsL	781179	c.-381T>C	upstream_gene_variant	0.46	streptomycin
rpsL	781185	c.-375T>C	upstream_gene_variant	0.48	streptomycin
rpsL	781189	c.-371T>C	upstream_gene_variant	0.5	streptomycin
rpsL	781197	c.-363A>G	upstream_gene_variant	0.52	streptomycin
rpsL	781209	c.-351C>G	upstream_gene_variant	0.54	streptomycin
rpsL	781218	c.-342C>G	upstream_gene_variant	0.5	streptomycin
rpsL	781224	c.-336T>C	upstream_gene_variant	0.5	streptomycin
rpsL	781245	c.-315C>T	upstream_gene_variant	0.48	streptomycin
rpsL	781258	c.-302C>T	upstream_gene_variant	0.39	streptomycin
rpsL	781263	c.-297G>T	upstream_gene_variant	0.38	streptomycin
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
rpsL	781592	c.33T>C	synonymous_variant	0.47	streptomycin
rpsL	781595	c.36T>C	synonymous_variant	0.47	streptomycin
rpsL	781605	p.Ile16Val	missense_variant	0.44	streptomycin	Uncertain significance
rpsL	781608	p.Ser17Ala	missense_variant	0.44	streptomycin
rpsL	781628	c.69T>C	synonymous_variant	0.52	streptomycin	Not assoc w R - Interim
rpsL	781649	c.90T>C	synonymous_variant	0.57	streptomycin
rpsL	781655	c.96T>C	synonymous_variant	0.5	streptomycin
rpsL	781658	c.99A>G	synonymous_variant	0.55	streptomycin
rpsL	781703	c.144G>T	synonymous_variant	0.4	streptomycin
rpsL	781728	c.169T>C	synonymous_variant	0.45	streptomycin
rpsL	781742	c.183C>T	synonymous_variant	0.38	streptomycin
rpsL	781751	c.192G>C	synonymous_variant	0.35	streptomycin
rpsL	781754	c.195G>T	synonymous_variant	0.35	streptomycin
rpsL	781760	c.201T>C	synonymous_variant	0.37	streptomycin
rpsL	781766	c.207C>T	synonymous_variant	0.39	streptomycin	Not assoc w R - Interim
rpsL	781778	c.219C>T	synonymous_variant	0.45	streptomycin
rpsL	781808	c.249C>T	synonymous_variant	0.49	streptomycin
rpsL	781832	c.273T>C	synonymous_variant	0.45	streptomycin
rpsL	781865	c.306G>C	synonymous_variant	0.52	streptomycin
rpsL	781868	c.309T>C	synonymous_variant	0.51	streptomycin
rpsL	781871	c.312G>C	synonymous_variant	0.51	streptomycin
rpsL	781892	c.333A>G	synonymous_variant	0.57	streptomycin
rpsL	781898	c.339A>T	synonymous_variant	0.61	streptomycin
rpsL	781904	c.345C>T	synonymous_variant	0.63	streptomycin	Not assoc w R - Interim
rpsL	781907	c.348T>C	synonymous_variant	0.63	streptomycin
rpsL	781916	c.357T>G	synonymous_variant	0.69	streptomycin
rpsL	781929	p.Gly124Ser	missense_variant	0.78	streptomycin	Uncertain significance
rplC	800357	c.-452C>A	upstream_gene_variant	1.0	linezolid	Not assoc w R
rplC	800516	c.-293G>C	upstream_gene_variant	0.56	linezolid
rplC	800537	c.-272C>T	upstream_gene_variant	0.57	linezolid
rplC	800546	c.-263T>C	upstream_gene_variant	0.54	linezolid
rplC	800567	c.-242A>G	upstream_gene_variant	0.71	linezolid
rplC	800579	c.-230C>T	upstream_gene_variant	0.73	linezolid
rplC	800585	c.-224T>A	upstream_gene_variant	0.71	linezolid
rplC	800600	c.-209G>A	upstream_gene_variant	0.69	linezolid
rplC	800612	c.-197A>G	upstream_gene_variant	0.65	linezolid
rplC	800618	c.-191T>G	upstream_gene_variant	0.66	linezolid
rplC	800621	c.-188G>A	upstream_gene_variant	0.66	linezolid
rplC	800624	c.-185G>A	upstream_gene_variant	0.67	linezolid
rplC	800633	c.-176T>C	upstream_gene_variant	0.68	linezolid
rplC	800648	c.-161A>T	upstream_gene_variant	0.73	linezolid
rplC	800690	c.-119C>G	upstream_gene_variant	0.75	linezolid
rplC	800703	c.-106_-104delTTGinsCTC	upstream_gene_variant	0.76	linezolid
rplC	800715	c.-94A>C	upstream_gene_variant	0.82	linezolid
rplC	800720	c.-89T>C	upstream_gene_variant	0.82	linezolid
rplC	800723	c.-86C>G	upstream_gene_variant	0.84	linezolid
rplC	800747	c.-62C>G	upstream_gene_variant	0.71	linezolid
rplC	800759	c.-50C>T	upstream_gene_variant	0.74	linezolid
rplC	800771	c.-38C>T	upstream_gene_variant	0.72	linezolid
rplC	800796	c.-13A>C	upstream_gene_variant	0.6	linezolid
rplC	800801	c.-8A>G	upstream_gene_variant	0.59	linezolid
rplC	800802	c.-6_-5delAG	upstream_gene_variant	0.55	linezolid
rplC	800814	c.6A>G	synonymous_variant	0.52	linezolid
rplC	800815	c.7C>A	synonymous_variant	0.55	linezolid
rplC	800820	c.12G>A	synonymous_variant	0.55	linezolid
rplC	800829	c.21C>G	synonymous_variant	0.67	linezolid
rplC	800844	c.36T>C	synonymous_variant	0.58	linezolid
rplC	800865	c.57A>G	synonymous_variant	0.57	linezolid
rplC	800867	p.Ser20Asn	missense_variant	0.57	linezolid
rplC	800898	c.90G>A	synonymous_variant	0.46	linezolid
rplC	800907	c.99C>G	synonymous_variant	0.53	linezolid
rplC	800916	c.108A>G	synonymous_variant	0.54	linezolid
rplC	801312	c.504G>C	synonymous_variant	0.33	linezolid
rplC	801321	c.513C>T	synonymous_variant	0.4	linezolid	Not assoc w R - Interim
Rv1129c	1254532	p.Met1?	start_lost	1.0	levofloxacin	Uncertain significance
					moxifloxacin	Uncertain significance
					isoniazid	Uncertain significance
					rifampicin	Uncertain significance
Rv1129c	1254543	c.-9T>G	upstream_gene_variant	1.0	levofloxacin	Uncertain significance
					moxifloxacin	Uncertain significance
					isoniazid	Not assoc w R
					rifampicin	Not assoc w R
Rv1129c	1254562	c.-28T>C	upstream_gene_variant	1.0	levofloxacin	Not assoc w R
					moxifloxacin	Not assoc w R
					isoniazid	Not assoc w R
					rifampicin	Not assoc w R
fbiC	1303581	c.651G>C	synonymous_variant	0.52	pretomanid
					delamanid
					clofazimine
fbiC	1303590	c.660A>G	synonymous_variant	0.58	pretomanid
					delamanid
					clofazimine
fbiC	1303611	c.681G>T	synonymous_variant	0.66	pretomanid
					delamanid
					clofazimine
fbiC	1303614	c.684C>G	synonymous_variant	0.7	pretomanid
					delamanid
					clofazimine
fbiC	1303617	c.687C>G	synonymous_variant	0.66	pretomanid
					delamanid
					clofazimine
fbiC	1303620	c.690C>T	synonymous_variant	0.66	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
fbiC	1303632	c.702T>C	synonymous_variant	0.54	pretomanid
					delamanid
					clofazimine
fbiC	1303654	c.724C>T	synonymous_variant	0.57	pretomanid
					delamanid
					clofazimine
fbiC	1303661	p.Val244Ala	missense_variant	0.53	pretomanid
					delamanid
					clofazimine
fbiC	1303663	c.733C>T	synonymous_variant	0.52	pretomanid
					delamanid
					clofazimine
fbiC	1303677	c.747C>G	synonymous_variant	0.48	pretomanid
					delamanid
					clofazimine
fbiC	1303770	c.840G>C	synonymous_variant	0.3	pretomanid
					delamanid
					clofazimine
fbiC	1303779	c.849G>A	synonymous_variant	0.25	pretomanid
					delamanid
					clofazimine
fbiC	1303785	c.855G>C	synonymous_variant	0.26	pretomanid
					delamanid
					clofazimine
fbiC	1303788	c.858T>C	synonymous_variant	0.26	pretomanid
					delamanid
					clofazimine
fbiC	1303794	c.864A>G	synonymous_variant	0.37	pretomanid
					delamanid
					clofazimine
fbiC	1303818	c.888C>G	synonymous_variant	0.46	pretomanid
					delamanid
					clofazimine
fbiC	1303827	c.897A>G	synonymous_variant	0.52	pretomanid
					delamanid
					clofazimine
fbiC	1303844	p.Ala305Asp	missense_variant	0.56	pretomanid
					delamanid
					clofazimine
fbiC	1303846	p.Phe306Val	missense_variant	0.58	pretomanid
					delamanid
					clofazimine
fbiC	1303860	c.930A>C	synonymous_variant	0.64	pretomanid
					delamanid
					clofazimine
fbiC	1303884	c.954T>C	synonymous_variant	0.67	pretomanid
					delamanid
					clofazimine
fbiC	1303893	c.963G>C	synonymous_variant	0.67	pretomanid
					delamanid
					clofazimine
fbiC	1303896	c.966G>A	synonymous_variant	0.65	pretomanid
					delamanid
					clofazimine
fbiC	1303905	c.975G>C	synonymous_variant	0.68	pretomanid
					delamanid
					clofazimine
fbiC	1303908	c.978C>A	synonymous_variant	0.63	pretomanid
					delamanid
					clofazimine
fbiC	1303911	c.981G>T	synonymous_variant	0.64	pretomanid
					delamanid
					clofazimine
fbiC	1303920	c.990C>T	synonymous_variant	0.68	pretomanid
					delamanid
					clofazimine
fbiC	1303947	c.1017T>C	synonymous_variant	0.51	pretomanid
					delamanid
					clofazimine
fbiC	1303948	p.Gly340Arg	missense_variant	0.51	pretomanid
					delamanid
					clofazimine
fbiC	1303961	p.Arg344Leu	missense_variant	0.51	pretomanid
					delamanid
					clofazimine
fbiC	1303971	c.1041T>C	synonymous_variant	0.46	pretomanid
					delamanid
					clofazimine
fbiC	1303973	p.Gly348Ala	missense_variant	0.42	pretomanid
					delamanid
					clofazimine
fbiC	1303980	c.1050G>C	synonymous_variant	0.45	pretomanid
					delamanid
					clofazimine
fbiC	1303995	c.1065C>T	synonymous_variant	0.38	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
fbiC	1304004	c.1074A>G	synonymous_variant	0.33	pretomanid
					delamanid
					clofazimine
fbiC	1304533	c.1603T>C	synonymous_variant	0.32	pretomanid
					delamanid
					clofazimine
fbiC	1304544	p.Asp538Glu	missense_variant	0.38	pretomanid
					delamanid
					clofazimine
fbiC	1304547	c.1617C>G	synonymous_variant	0.38	pretomanid
					delamanid
					clofazimine
fbiC	1304550	c.1620C>G	synonymous_variant	0.38	pretomanid
					delamanid
					clofazimine
fbiC	1304556	c.1626C>T	synonymous_variant	0.36	pretomanid
					delamanid
					clofazimine
fbiC	1304559	p.Glu543Asp	missense_variant	0.38	pretomanid
					delamanid
					clofazimine
fbiC	1304567	p.Phe546Tyr	missense_variant	0.36	pretomanid
					delamanid
					clofazimine
fbiC	1304580	c.1650T>C	synonymous_variant	0.52	pretomanid
					delamanid
					clofazimine
fbiC	1304610	c.1680C>G	synonymous_variant	0.37	pretomanid
					delamanid
					clofazimine
fbiC	1304625	c.1695C>T	synonymous_variant	0.4	pretomanid
					delamanid
					clofazimine
fbiC	1304763	c.1833C>G	synonymous_variant	0.55	pretomanid
					delamanid
					clofazimine
fbiC	1304769	c.1839C>T	synonymous_variant	0.52	pretomanid
					delamanid
					clofazimine
fbiC	1304784	c.1854T>G	synonymous_variant	0.52	pretomanid
					delamanid
					clofazimine
fbiC	1304787	c.1857T>G	synonymous_variant	0.52	pretomanid
					delamanid
					clofazimine
fbiC	1304790	c.1860C>G	synonymous_variant	0.55	pretomanid
					delamanid
					clofazimine
fbiC	1304799	c.1869G>C	synonymous_variant	0.55	pretomanid
					delamanid
					clofazimine
fbiC	1304808	c.1878C>G	synonymous_variant	0.57	pretomanid
					delamanid
					clofazimine
fbiC	1304811	c.1881C>G	synonymous_variant	0.58	pretomanid
					delamanid
					clofazimine
fbiC	1304829	c.1899T>C	synonymous_variant	0.63	pretomanid
					delamanid
					clofazimine
fbiC	1304856	c.1926C>G	synonymous_variant	0.63	pretomanid
					delamanid
					clofazimine
fbiC	1304869	c.1939C>T	synonymous_variant	0.61	pretomanid
					delamanid
					clofazimine
fbiC	1304887	c.1957C>T	synonymous_variant	0.64	pretomanid
					delamanid
					clofazimine
fbiC	1304891	p.Ile654Thr	missense_variant	0.67	pretomanid
					delamanid
					clofazimine
fbiC	1304895	c.1965C>G	synonymous_variant	0.67	pretomanid
					delamanid
					clofazimine
fbiC	1304910	c.1980G>A	synonymous_variant	0.64	pretomanid
					delamanid
					clofazimine
fbiC	1304913	c.1983G>C	synonymous_variant	0.62	pretomanid
					delamanid
					clofazimine
fbiC	1304916	c.1986T>C	synonymous_variant	0.62	pretomanid
					delamanid
					clofazimine
fbiC	1304922	c.1992C>T	synonymous_variant	0.62	pretomanid
					delamanid
					clofazimine
fbiC	1304928	c.1998T>C	synonymous_variant	0.63	pretomanid
					delamanid
					clofazimine
fbiC	1304937	c.2007G>C	synonymous_variant	0.56	pretomanid
					delamanid
					clofazimine
fbiC	1304940	c.2010A>G	synonymous_variant	0.5	pretomanid
					delamanid
					clofazimine
fbiC	1304943	c.2013C>A	synonymous_variant	0.5	pretomanid
					delamanid
					clofazimine
fbiC	1304946	c.2016G>C	synonymous_variant	0.56	pretomanid
					delamanid
					clofazimine
fbiC	1304958	c.2028T>G	synonymous_variant	0.61	pretomanid
					delamanid
					clofazimine
fbiC	1304961	c.2031C>G	synonymous_variant	0.63	pretomanid
					delamanid
					clofazimine
fbiC	1304983	c.2053C>T	synonymous_variant	0.7	pretomanid
					delamanid
					clofazimine
fbiC	1304991	c.2061G>C	synonymous_variant	0.67	pretomanid
					delamanid
					clofazimine
fbiC	1305001	p.Ile691Val	missense_variant	0.69	pretomanid
					delamanid
					clofazimine
fbiC	1305006	c.2076A>G	synonymous_variant	0.69	pretomanid
					delamanid
					clofazimine
fbiC	1305015	c.2085G>C	synonymous_variant	0.73	pretomanid
					delamanid
					clofazimine
fbiC	1305018	c.2088C>G	synonymous_variant	0.71	pretomanid
					delamanid
					clofazimine
fbiC	1305042	c.2112A>G	synonymous_variant	0.64	pretomanid
					delamanid
					clofazimine
fbiC	1305045	c.2115A>G	synonymous_variant	0.58	pretomanid
					delamanid
					clofazimine
fbiC	1305051	c.2121G>C	synonymous_variant	0.58	pretomanid
					delamanid
					clofazimine
fbiC	1305120	c.2190G>A	synonymous_variant	0.6	pretomanid
					delamanid
					clofazimine
fbiC	1305126	c.2196T>C	synonymous_variant	0.62	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
fbiC	1305135	c.2205C>G	synonymous_variant	0.59	pretomanid
					delamanid
					clofazimine
fbiC	1305150	c.2220C>G	synonymous_variant	0.67	pretomanid
					delamanid
					clofazimine
fbiC	1305154	c.2224T>C	synonymous_variant	0.67	pretomanid
					delamanid
					clofazimine
fbiC	1305177	c.2247A>G	synonymous_variant	0.5	pretomanid
					delamanid
					clofazimine
fbiC	1305181	c.2251_2253delTTGinsCTT	synonymous_variant	0.46	pretomanid
					delamanid
					clofazimine
fbiC	1305186	c.2256C>T	synonymous_variant	0.48	pretomanid
					delamanid
					clofazimine
fbiC	1305198	c.2268G>C	synonymous_variant	0.5	pretomanid
					delamanid
					clofazimine
fbiC	1305204	c.2274C>G	synonymous_variant	0.43	pretomanid
					delamanid
					clofazimine
fbiC	1305207	c.2277C>G	synonymous_variant	0.47	pretomanid
					delamanid
					clofazimine
fbiC	1305215	p.Ser762Thr	missense_variant	0.44	pretomanid
					delamanid
					clofazimine
fbiC	1305219	c.2289T>C	synonymous_variant	0.4	pretomanid
					delamanid
					clofazimine
fbiC	1305234	c.2304G>A	synonymous_variant	0.33	pretomanid
					delamanid
					clofazimine	Not assoc w R - Interim
fbiC	1305237	c.2307A>G	synonymous_variant	0.36	pretomanid
					delamanid
					clofazimine
fbiC	1305240	c.2310T>C	synonymous_variant	0.34	pretomanid
					delamanid
					clofazimine
fbiC	1305243	c.2313T>G	synonymous_variant	0.34	pretomanid
					delamanid
					clofazimine	Not assoc w R - Interim
fbiC	1305249	c.2319G>C	synonymous_variant	0.33	pretomanid
					delamanid
					clofazimine
fbiC	1305250	c.2320C>A	synonymous_variant	0.33	pretomanid
					delamanid
					clofazimine
fbiC	1305259	c.2329_2331delTTGinsCTC	synonymous_variant	0.44	pretomanid
					delamanid
					clofazimine
fbiC	1305267	c.2337C>G	synonymous_variant	0.47	pretomanid
					delamanid
					clofazimine
fbiC	1305274	p.Ser782Ala	missense_variant	0.51	pretomanid
					delamanid
					clofazimine
fbiC	1305300	c.2370A>G	synonymous_variant	0.54	pretomanid
					delamanid
					clofazimine
fbiC	1305303	c.2373T>C	synonymous_variant	0.53	pretomanid
					delamanid
					clofazimine
fbiC	1305306	c.2376A>G	synonymous_variant	0.55	pretomanid
					delamanid
					clofazimine
fbiC	1305311	p.Arg794Gln	missense_variant	0.57	pretomanid
					delamanid
					clofazimine
fbiC	1305331	p.Glu801Asn	missense_variant	0.59	pretomanid
					delamanid
					clofazimine
fbiC	1305336	c.2406T>C	synonymous_variant	0.58	pretomanid
					delamanid
					clofazimine
fbiC	1305360	c.2430G>C	synonymous_variant	0.5	pretomanid
					delamanid
					clofazimine
fbiC	1305372	c.2442G>A	synonymous_variant	0.42	pretomanid
					delamanid
					clofazimine	Not assoc w R - Interim
fbiC	1305375	c.2445C>G	synonymous_variant	0.41	pretomanid
					delamanid
					clofazimine
sigE	1364742	c.330A>G	synonymous_variant	0.44	pyrazinamide
sigE	1364751	c.339C>G	synonymous_variant	0.53	pyrazinamide
sigE	1364760	c.348C>G	synonymous_variant	0.61	pyrazinamide
sigE	1364763	c.351T>C	synonymous_variant	0.63	pyrazinamide
sigE	1364790	c.378T>C	synonymous_variant	0.67	pyrazinamide
sigE	1364796	c.384G>A	synonymous_variant	0.67	pyrazinamide
sigE	1364799	c.387G>C	synonymous_variant	0.68	pyrazinamide
sigE	1364805	c.393C>T	synonymous_variant	0.61	pyrazinamide
sigE	1364811	c.399A>G	synonymous_variant	0.63	pyrazinamide
sigE	1364820	c.408A>G	synonymous_variant	0.67	pyrazinamide
sigE	1364832	c.420C>G	synonymous_variant	0.63	pyrazinamide
sigE	1364839	c.427T>C	synonymous_variant	0.64	pyrazinamide
sigE	1364847	c.435G>C	synonymous_variant	0.63	pyrazinamide
sigE	1364868	c.456T>G	synonymous_variant	0.57	pyrazinamide
sigE	1364887	c.475_477delTTAinsCTG	synonymous_variant	0.44	pyrazinamide
sigE	1364919	c.507T>C	synonymous_variant	0.39	pyrazinamide
sigE	1365042	c.630G>C	synonymous_variant	0.37	pyrazinamide
sigE	1365063	c.651A>C	synonymous_variant	0.41	pyrazinamide
sigE	1365072	c.660G>C	synonymous_variant	0.41	pyrazinamide
embR	1417019	p.Cys110Tyr	missense_variant	1.0	ethambutol	Not assoc w R
embR	1417554	c.-207C>G	upstream_gene_variant	1.0	ethambutol
embR	1417857	c.-511_-510delGGinsAA	upstream_gene_variant	0.57	ethambutol
embR	1417879	c.-532A>C	upstream_gene_variant	0.62	ethambutol
embR	1417880	c.-535_-533delAGCinsGGA	upstream_gene_variant	0.62	ethambutol
embR	1417889	c.-542G>C	upstream_gene_variant	0.67	ethambutol
embR	1417895	c.-548C>T	upstream_gene_variant	0.67	ethambutol
embR	1417898	c.-551G>T	upstream_gene_variant	0.73	ethambutol
embR	1417907	c.-560G>C	upstream_gene_variant	0.57	ethambutol
embR	1417910	c.-563T>C	upstream_gene_variant	0.57	ethambutol
embR	1417925	c.-579_-578delCCinsAG	upstream_gene_variant	0.5	ethambutol
embR	1417943	c.-596A>C	upstream_gene_variant	0.38	ethambutol
atpE	1460816	c.-229T>C	upstream_gene_variant	0.28	bedaquiline
atpE	1461040	c.-4_-3delGG	upstream_gene_variant	0.54	bedaquiline
atpE	1461062	c.18T>A	synonymous_variant	0.67	bedaquiline
atpE	1461149	c.105T>G	synonymous_variant	0.47	bedaquiline
atpE	1461164	c.120C>T	synonymous_variant	0.35	bedaquiline
atpE	1461167	c.123G>C	synonymous_variant	0.33	bedaquiline
atpE	1461170	c.126A>G	synonymous_variant	0.35	bedaquiline
atpE	1461179	c.135G>A	synonymous_variant	0.33	bedaquiline
atpE	1461182	c.138A>G	synonymous_variant	0.33	bedaquiline
atpE	1461185	c.141G>C	synonymous_variant	0.32	bedaquiline
atpE	1461188	c.144G>T	synonymous_variant	0.36	bedaquiline
atpE	1461191	c.147G>C	synonymous_variant	0.38	bedaquiline
atpE	1461197	c.153A>C	synonymous_variant	0.45	bedaquiline
atpE	1461212	c.168C>G	synonymous_variant	0.44	bedaquiline
rrs	1471499	n.-347C>T	upstream_gene_variant	0.33	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
inhA	1673565	c.-637G>T	upstream_gene_variant	0.53	isoniazid
inhA	1673565	c.-637G>T	upstream_gene_variant	0.53	ethionamide
inhA	1673574	c.-628C>G	upstream_gene_variant	0.54	isoniazid
inhA	1673574	c.-628C>G	upstream_gene_variant	0.54	ethionamide
inhA	1673607	c.-595T>C	upstream_gene_variant	0.67	isoniazid
inhA	1673607	c.-595T>C	upstream_gene_variant	0.67	ethionamide
inhA	1673609	c.-593G>C	upstream_gene_variant	0.7	isoniazid
inhA	1673609	c.-593G>C	upstream_gene_variant	0.7	ethionamide
inhA	1673616	c.-586A>G	upstream_gene_variant	0.7	isoniazid
inhA	1673616	c.-586A>G	upstream_gene_variant	0.7	ethionamide
inhA	1673625	c.-577C>G	upstream_gene_variant	0.71	isoniazid
inhA	1673625	c.-577C>G	upstream_gene_variant	0.71	ethionamide
inhA	1673633	c.-569G>A	upstream_gene_variant	0.72	isoniazid
inhA	1673633	c.-569G>A	upstream_gene_variant	0.72	ethionamide
inhA	1673657	c.-545_-544delCGinsAA	upstream_gene_variant	0.61	isoniazid
inhA	1673657	c.-545_-544delCGinsAA	upstream_gene_variant	0.61	ethionamide
inhA	1673660	c.-542C>A	upstream_gene_variant	0.59	isoniazid
inhA	1673660	c.-542C>A	upstream_gene_variant	0.59	ethionamide
inhA	1673664	c.-538A>C	upstream_gene_variant	0.61	isoniazid
inhA	1673664	c.-538A>C	upstream_gene_variant	0.61	ethionamide
inhA	1673679	c.-523T>G	upstream_gene_variant	0.65	isoniazid
inhA	1673679	c.-523T>G	upstream_gene_variant	0.65	ethionamide
inhA	1673685	c.-517C>T	upstream_gene_variant	0.68	isoniazid
inhA	1673685	c.-517C>T	upstream_gene_variant	0.68	ethionamide
inhA	1673710	c.-492_-490delCTAinsGTC	upstream_gene_variant	0.52	isoniazid
inhA	1673710	c.-492_-490delCTAinsGTC	upstream_gene_variant	0.52	ethionamide
inhA	1673721	c.-481C>T	upstream_gene_variant	0.54	isoniazid
inhA	1673721	c.-481C>T	upstream_gene_variant	0.54	ethionamide
inhA	1673724	c.-478A>G	upstream_gene_variant	0.51	isoniazid
inhA	1673724	c.-478A>G	upstream_gene_variant	0.51	ethionamide
inhA	1673730	c.-472C>G	upstream_gene_variant	0.47	isoniazid
inhA	1673730	c.-472C>G	upstream_gene_variant	0.47	ethionamide
inhA	1673733	c.-469G>C	upstream_gene_variant	0.47	isoniazid
inhA	1673733	c.-469G>C	upstream_gene_variant	0.47	ethionamide
inhA	1673745	c.-457G>A	upstream_gene_variant	0.41	isoniazid
inhA	1673745	c.-457G>A	upstream_gene_variant	0.41	ethionamide
inhA	1673748	c.-454A>G	upstream_gene_variant	0.45	isoniazid
inhA	1673748	c.-454A>G	upstream_gene_variant	0.45	ethionamide
inhA	1673749	c.-453_-452delAAinsCG	upstream_gene_variant	0.44	isoniazid
inhA	1673749	c.-453_-452delAAinsCG	upstream_gene_variant	0.44	ethionamide
inhA	1673754	c.-448C>T	upstream_gene_variant	0.45	isoniazid
inhA	1673754	c.-448C>T	upstream_gene_variant	0.45	ethionamide
inhA	1673767	c.-435A>G	upstream_gene_variant	0.47	isoniazid
inhA	1673767	c.-435A>G	upstream_gene_variant	0.47	ethionamide
inhA	1673865	c.-337C>G	upstream_gene_variant	0.33	isoniazid
inhA	1673865	c.-337C>G	upstream_gene_variant	0.33	ethionamide
inhA	1673901	c.-301A>G	upstream_gene_variant	0.44	isoniazid
inhA	1673901	c.-301A>G	upstream_gene_variant	0.44	ethionamide
inhA	1673916	c.-286A>T	upstream_gene_variant	0.45	isoniazid
inhA	1673916	c.-286A>T	upstream_gene_variant	0.45	ethionamide
inhA	1673922	c.-280T>C	upstream_gene_variant	0.48	isoniazid
inhA	1673922	c.-280T>C	upstream_gene_variant	0.48	ethionamide
inhA	1673949	c.-253G>A	upstream_gene_variant	0.51	isoniazid
inhA	1673949	c.-253G>A	upstream_gene_variant	0.51	ethionamide
inhA	1673955	c.-247G>C	upstream_gene_variant	0.51	isoniazid
inhA	1673955	c.-247G>C	upstream_gene_variant	0.51	ethionamide
inhA	1673960	c.-242_-241delCAinsTC	upstream_gene_variant	0.51	isoniazid
inhA	1673960	c.-242_-241delCAinsTC	upstream_gene_variant	0.51	ethionamide
inhA	1673967	c.-235G>C	upstream_gene_variant	0.54	isoniazid
inhA	1673967	c.-235G>C	upstream_gene_variant	0.54	ethionamide
inhA	1673982	c.-220G>C	upstream_gene_variant	0.61	isoniazid
inhA	1673982	c.-220G>C	upstream_gene_variant	0.61	ethionamide
inhA	1673991	c.-211C>T	upstream_gene_variant	0.61	isoniazid
inhA	1673991	c.-211C>T	upstream_gene_variant	0.61	ethionamide
inhA	1674015	c.-187C>G	upstream_gene_variant	0.56	isoniazid
inhA	1674015	c.-187C>G	upstream_gene_variant	0.56	ethionamide
inhA	1674018	c.-184G>C	upstream_gene_variant	0.54	isoniazid
inhA	1674018	c.-184G>C	upstream_gene_variant	0.54	ethionamide
inhA	1674024	c.-178T>C	upstream_gene_variant	0.54	isoniazid
inhA	1674024	c.-178T>C	upstream_gene_variant	0.54	ethionamide
inhA	1674033	c.-169T>C	upstream_gene_variant	0.48	isoniazid
inhA	1674033	c.-169T>C	upstream_gene_variant	0.48	ethionamide
inhA	1674037	c.-165C>G	upstream_gene_variant	0.48	isoniazid
inhA	1674037	c.-165C>G	upstream_gene_variant	0.48	ethionamide
inhA	1674042	c.-160G>T	upstream_gene_variant	0.47	isoniazid
inhA	1674042	c.-160G>T	upstream_gene_variant	0.47	ethionamide
inhA	1674045	c.-157G>A	upstream_gene_variant	0.47	isoniazid
inhA	1674045	c.-157G>A	upstream_gene_variant	0.47	ethionamide
inhA	1674054	c.-148T>C	upstream_gene_variant	0.46	isoniazid
inhA	1674054	c.-148T>C	upstream_gene_variant	0.46	ethionamide
inhA	1674060	c.-142A>T	upstream_gene_variant	0.48	isoniazid
inhA	1674060	c.-142A>T	upstream_gene_variant	0.48	ethionamide
inhA	1674063	c.-139G>C	upstream_gene_variant	0.48	isoniazid
inhA	1674063	c.-139G>C	upstream_gene_variant	0.48	ethionamide
inhA	1674069	c.-133G>C	upstream_gene_variant	0.46	isoniazid
inhA	1674069	c.-133G>C	upstream_gene_variant	0.46	ethionamide
inhA	1674079	c.-123C>G	upstream_gene_variant	0.46	isoniazid
inhA	1674079	c.-123C>G	upstream_gene_variant	0.46	ethionamide
inhA	1674114	c.-88T>C	upstream_gene_variant	0.44	isoniazid
inhA	1674114	c.-88T>C	upstream_gene_variant	0.44	ethionamide
inhA	1674123	c.-79T>C	upstream_gene_variant	0.39	isoniazid
inhA	1674123	c.-79T>C	upstream_gene_variant	0.39	ethionamide
inhA	1674129	c.-73C>T	upstream_gene_variant	0.42	isoniazid
inhA	1674129	c.-73C>T	upstream_gene_variant	0.42	ethionamide
inhA	1674132	c.-70T>C	upstream_gene_variant	0.44	isoniazid
inhA	1674132	c.-70T>C	upstream_gene_variant	0.44	ethionamide
inhA	1674138	c.-64C>G	upstream_gene_variant	0.42	isoniazid
inhA	1674138	c.-64C>G	upstream_gene_variant	0.42	ethionamide
inhA	1674141	c.-61T>C	upstream_gene_variant	0.38	isoniazid
inhA	1674141	c.-61T>C	upstream_gene_variant	0.38	ethionamide
inhA	1674150	c.-52C>T	upstream_gene_variant	0.33	isoniazid
inhA	1674150	c.-52C>T	upstream_gene_variant	0.33	ethionamide
inhA	1674573	c.372G>C	synonymous_variant	0.39	isoniazid
inhA	1674573	c.372G>C	synonymous_variant	0.39	ethionamide
inhA	1674576	c.375T>C	synonymous_variant	0.37	isoniazid
inhA	1674576	c.375T>C	synonymous_variant	0.37	ethionamide
inhA	1674582	c.381T>C	synonymous_variant	0.35	isoniazid
inhA	1674582	c.381T>C	synonymous_variant	0.35	ethionamide
inhA	1674585	c.384T>C	synonymous_variant	0.35	isoniazid
inhA	1674585	c.384T>C	synonymous_variant	0.35	ethionamide
inhA	1674588	c.387G>C	synonymous_variant	0.33	isoniazid
inhA	1674588	c.387G>C	synonymous_variant	0.33	ethionamide
inhA	1674589	p.Met130Leu	missense_variant	0.33	isoniazid
inhA	1674589	p.Met130Leu	missense_variant	0.33	ethionamide
inhA	1674594	c.393C>A	synonymous_variant	0.33	isoniazid
inhA	1674594	c.393C>A	synonymous_variant	0.33	ethionamide
inhA	1674597	c.396G>A	synonymous_variant	0.32	isoniazid
inhA	1674597	c.396G>A	synonymous_variant	0.32	ethionamide
inhA	1674600	c.399G>A	synonymous_variant	0.3	isoniazid
inhA	1674600	c.399G>A	synonymous_variant	0.3	ethionamide
inhA	1674601	c.400C>T	synonymous_variant	0.3	isoniazid
inhA	1674601	c.400C>T	synonymous_variant	0.3	ethionamide
inhA	1674618	c.417C>T	synonymous_variant	0.41	isoniazid
inhA	1674618	c.417C>T	synonymous_variant	0.41	ethionamide
inhA	1674624	c.423A>C	synonymous_variant	0.41	isoniazid
inhA	1674624	c.423A>C	synonymous_variant	0.41	ethionamide
inhA	1674627	c.426T>C	synonymous_variant	0.42	isoniazid
inhA	1674627	c.426T>C	synonymous_variant	0.42	ethionamide
inhA	1674628	p.Ser143Gly	missense_variant	0.42	isoniazid
inhA	1674628	p.Ser143Gly	missense_variant	0.42	ethionamide
inhA	1674654	c.453G>C	synonymous_variant	0.55	isoniazid
inhA	1674654	c.453G>C	synonymous_variant	0.55	ethionamide
inhA	1674656	p.Ser152Thr	missense_variant	0.44	isoniazid
inhA	1674656	p.Ser152Thr	missense_variant	0.44	ethionamide
inhA	1674660	c.459G>C	synonymous_variant	0.47	isoniazid
inhA	1674660	c.459G>C	synonymous_variant	0.47	ethionamide
inhA	1674696	c.495G>A	synonymous_variant	0.61	isoniazid
inhA	1674696	c.495G>A	synonymous_variant	0.61	ethionamide
inhA	1674703	c.502T>C	synonymous_variant	0.59	isoniazid
inhA	1674703	c.502T>C	synonymous_variant	0.59	ethionamide
inhA	1674708	c.507G>A	synonymous_variant	0.54	isoniazid
inhA	1674708	c.507G>A	synonymous_variant	0.54	ethionamide
inhA	1674718	c.517A>C	synonymous_variant	0.57	isoniazid
inhA	1674718	c.517A>C	synonymous_variant	0.57	ethionamide
inhA	1674726	c.525G>C	synonymous_variant	0.57	isoniazid
inhA	1674726	c.525G>C	synonymous_variant	0.57	ethionamide
inhA	1674756	c.555T>C	synonymous_variant	0.4	isoniazid	Not assoc w R - Interim
inhA	1674756	c.555T>C	synonymous_variant	0.4	ethionamide	Not assoc w R - Interim
inhA	1674762	c.561T>C	synonymous_variant	0.38	isoniazid
inhA	1674762	c.561T>C	synonymous_variant	0.38	ethionamide
inhA	1674765	c.564C>G	synonymous_variant	0.32	isoniazid
inhA	1674765	c.564C>G	synonymous_variant	0.32	ethionamide
inhA	1674834	c.633C>G	synonymous_variant	0.4	isoniazid
inhA	1674834	c.633C>G	synonymous_variant	0.4	ethionamide
inhA	1674837	c.636C>T	synonymous_variant	0.43	isoniazid	Not assoc w R - Interim
inhA	1674837	c.636C>T	synonymous_variant	0.43	ethionamide	Not assoc w R - Interim
inhA	1674850	c.649C>T	synonymous_variant	0.52	isoniazid	Not assoc w R - Interim
inhA	1674850	c.649C>T	synonymous_variant	0.52	ethionamide	Not assoc w R - Interim
inhA	1674858	c.657G>A	synonymous_variant	0.57	isoniazid
inhA	1674858	c.657G>A	synonymous_variant	0.57	ethionamide
inhA	1674870	c.669T>C	synonymous_variant	0.61	isoniazid
inhA	1674870	c.669T>C	synonymous_variant	0.61	ethionamide
inhA	1674879	c.678T>G	synonymous_variant	0.67	isoniazid
inhA	1674879	c.678T>G	synonymous_variant	0.67	ethionamide
inhA	1674882	c.681G>C	synonymous_variant	0.66	isoniazid
inhA	1674882	c.681G>C	synonymous_variant	0.66	ethionamide
inhA	1674904	p.Ala235Pro	missense_variant	0.81	isoniazid
inhA	1674904	p.Ala235Pro	missense_variant	0.81	ethionamide
inhA	1674909	c.708G>T	synonymous_variant	0.81	isoniazid
inhA	1674909	c.708G>T	synonymous_variant	0.81	ethionamide
inhA	1674930	c.729C>T	synonymous_variant	0.72	isoniazid
inhA	1674930	c.729C>T	synonymous_variant	0.72	ethionamide
inhA	1674942	c.741T>C	synonymous_variant	0.61	isoniazid
inhA	1674942	c.741T>C	synonymous_variant	0.61	ethionamide
inhA	1674945	p.Asp248Glu	missense_variant	0.59	isoniazid
inhA	1674945	p.Asp248Glu	missense_variant	0.59	ethionamide
inhA	1674954	c.753G>C	synonymous_variant	0.63	isoniazid
inhA	1674954	c.753G>C	synonymous_variant	0.63	ethionamide
inhA	1674960	c.759C>G	synonymous_variant	0.62	isoniazid
inhA	1674960	c.759C>G	synonymous_variant	0.62	ethionamide
inhA	1674963	c.762G>C	synonymous_variant	0.58	isoniazid
inhA	1674963	c.762G>C	synonymous_variant	0.58	ethionamide
inhA	1674984	c.783C>T	synonymous_variant	0.47	isoniazid	Not assoc w R - Interim
inhA	1674984	c.783C>T	synonymous_variant	0.47	ethionamide	Not assoc w R - Interim
inhA	1674987	c.786C>T	synonymous_variant	0.44	isoniazid
inhA	1674987	c.786C>T	synonymous_variant	0.44	ethionamide
inhA	1674993	c.792G>T	synonymous_variant	0.5	isoniazid
inhA	1674993	c.792G>T	synonymous_variant	0.5	ethionamide
rpsA	1833589	c.48A>T	synonymous_variant	0.45	pyrazinamide
rpsA	1833593	p.Ser18Thr	missense_variant	0.47	pyrazinamide
rpsA	1833661	c.120A>G	synonymous_variant	0.48	pyrazinamide
rpsA	1833664	c.123C>A	synonymous_variant	0.52	pyrazinamide
rpsA	1833724	c.183C>G	synonymous_variant	0.73	pyrazinamide
rpsA	1833727	c.186G>C	synonymous_variant	0.73	pyrazinamide
rpsA	1833742	c.201A>G	synonymous_variant	0.76	pyrazinamide
rpsA	1833745	c.204G>C	synonymous_variant	0.77	pyrazinamide
rpsA	1833802	c.261A>G	synonymous_variant	0.8	pyrazinamide
rpsA	1833811	c.270G>T	synonymous_variant	0.83	pyrazinamide
rpsA	1833820	c.279G>A	synonymous_variant	0.81	pyrazinamide
rpsA	1833856	c.315A>G	synonymous_variant	0.58	pyrazinamide
rpsA	1833859	c.318C>T	synonymous_variant	0.57	pyrazinamide
rpsA	1833874	c.333T>C	synonymous_variant	0.58	pyrazinamide
rpsA	1833894	p.Ala118Glu	missense_variant	0.63	pyrazinamide
rpsA	1833928	c.387G>C	synonymous_variant	0.66	pyrazinamide
rpsA	1833940	c.399C>G	synonymous_variant	0.76	pyrazinamide
rpsA	1833970	c.429G>C	synonymous_variant	0.73	pyrazinamide
rpsA	1833979	c.438T>C	synonymous_variant	0.69	pyrazinamide
rpsA	1834000	c.459G>C	synonymous_variant	0.68	pyrazinamide
rpsA	1834012	c.471G>C	synonymous_variant	0.62	pyrazinamide
rpsA	1834018	c.477C>T	synonymous_variant	0.61	pyrazinamide
rpsA	1834021	c.480C>T	synonymous_variant	0.57	pyrazinamide
rpsA	1834030	c.489C>G	synonymous_variant	0.55	pyrazinamide
rpsA	1834042	c.501G>A	synonymous_variant	0.52	pyrazinamide
rpsA	1834051	c.510G>A	synonymous_variant	0.54	pyrazinamide
rpsA	1834093	c.552G>C	synonymous_variant	0.5	pyrazinamide
rpsA	1834099	c.558C>G	synonymous_variant	0.43	pyrazinamide
rpsA	1834102	c.561T>A	synonymous_variant	0.43	pyrazinamide
rpsA	1834108	c.567C>G	synonymous_variant	0.43	pyrazinamide
rpsA	1834117	c.576G>A	synonymous_variant	0.32	pyrazinamide	Not assoc w R - Interim
rpsA	1834189	c.648G>C	synonymous_variant	0.38	pyrazinamide
rpsA	1834195	c.654G>C	synonymous_variant	0.42	pyrazinamide
rpsA	1834213	c.672G>C	synonymous_variant	0.42	pyrazinamide
rpsA	1834222	c.681T>C	synonymous_variant	0.48	pyrazinamide
rpsA	1834225	c.684C>G	synonymous_variant	0.42	pyrazinamide
rpsA	1834231	c.690T>G	synonymous_variant	0.42	pyrazinamide
rpsA	1834240	c.699T>C	synonymous_variant	0.45	pyrazinamide
rpsA	1834249	c.708T>C	synonymous_variant	0.47	pyrazinamide
rpsA	1834261	c.720A>G	synonymous_variant	0.42	pyrazinamide	Not assoc w R - Interim
rpsA	1834264	c.723G>C	synonymous_variant	0.42	pyrazinamide
rpsA	1834297	c.756C>G	synonymous_variant	0.62	pyrazinamide
rpsA	1834303	c.762T>G	synonymous_variant	0.63	pyrazinamide
rpsA	1834306	c.765T>C	synonymous_variant	0.59	pyrazinamide
rpsA	1834319	p.Val260Ile	missense_variant	0.47	pyrazinamide	Uncertain significance
rpsA	1834348	c.807T>C	synonymous_variant	0.62	pyrazinamide	Not assoc w R - Interim
rpsA	1834366	c.825A>G	synonymous_variant	0.64	pyrazinamide	Not assoc w R - Interim
rpsA	1834369	c.828C>G	synonymous_variant	0.59	pyrazinamide
rpsA	1834396	c.855G>C	synonymous_variant	0.6	pyrazinamide
rpsA	1834411	c.870T>C	synonymous_variant	0.66	pyrazinamide
rpsA	1834451	c.910T>C	synonymous_variant	0.59	pyrazinamide
rpsA	1834456	c.915T>G	synonymous_variant	0.61	pyrazinamide
rpsA	1834459	c.918G>C	synonymous_variant	0.63	pyrazinamide
rpsA	1834468	c.927A>G	synonymous_variant	0.66	pyrazinamide
rpsA	1834477	c.936C>A	synonymous_variant	0.7	pyrazinamide
rpsA	1834489	c.948T>C	synonymous_variant	0.74	pyrazinamide
rpsA	1834499	c.958C>T	synonymous_variant	0.74	pyrazinamide
rpsA	1834507	c.966C>T	synonymous_variant	0.79	pyrazinamide
rpsA	1834528	c.987T>C	synonymous_variant	0.81	pyrazinamide
rpsA	1834534	c.993C>G	synonymous_variant	0.82	pyrazinamide
rpsA	1834546	c.1005T>C	synonymous_variant	0.82	pyrazinamide
rpsA	1834555	c.1014T>C	synonymous_variant	0.88	pyrazinamide
rpsA	1834606	c.1065C>T	synonymous_variant	0.81	pyrazinamide
rpsA	1834609	c.1068T>C	synonymous_variant	0.8	pyrazinamide
rpsA	1834618	c.1077G>C	synonymous_variant	0.79	pyrazinamide
rpsA	1834633	c.1092A>G	synonymous_variant	0.79	pyrazinamide
rpsA	1834639	c.1098T>C	synonymous_variant	0.73	pyrazinamide
rpsA	1834654	c.1113G>A	synonymous_variant	0.77	pyrazinamide
rpsA	1834666	c.1125G>C	synonymous_variant	0.67	pyrazinamide
rpsA	1834669	c.1128G>C	synonymous_variant	0.65	pyrazinamide
rpsA	1834690	c.1149T>C	synonymous_variant	0.56	pyrazinamide
tsnR	1853370	c.-236_-234delGCAinsTCG	upstream_gene_variant	0.7	linezolid
tsnR	1853384	c.-222G>C	upstream_gene_variant	0.69	linezolid
tsnR	1853387	c.-219T>C	upstream_gene_variant	0.69	linezolid
tsnR	1853393	c.-213C>T	upstream_gene_variant	0.69	linezolid
tsnR	1853394	c.-212_-211delCTinsGC	upstream_gene_variant	0.67	linezolid
tsnR	1853418	c.-188_-186delCTTinsTTG	upstream_gene_variant	0.69	linezolid
tsnR	1853429	c.-177G>C	upstream_gene_variant	0.67	linezolid
tsnR	1853432	c.-174G>C	upstream_gene_variant	0.65	linezolid
tsnR	1853459	c.-147G>C	upstream_gene_variant	0.54	linezolid
tsnR	1853462	c.-144A>G	upstream_gene_variant	0.5	linezolid
tsnR	1853468	c.-138C>G	upstream_gene_variant	0.5	linezolid
tsnR	1853474	c.-132C>T	upstream_gene_variant	0.5	linezolid
tsnR	1853477	c.-129T>C	upstream_gene_variant	0.48	linezolid
tsnR	1853485	c.-121G>C	upstream_gene_variant	0.45	linezolid
tsnR	1853489	c.-117C>T	upstream_gene_variant	0.42	linezolid
tsnR	1853495	c.-111G>A	upstream_gene_variant	0.35	linezolid
tsnR	1853974	c.369C>T	synonymous_variant	1.0	linezolid	Not assoc w R
tsnR	1854045	p.Tyr147Cys	missense_variant	1.0	linezolid	Not assoc w R
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917960	c.21T>C	synonymous_variant	0.5	capreomycin
tlyA	1917970	c.31_33delCTAinsTTG	synonymous_variant	0.57	capreomycin
tlyA	1917975	c.36C>A	synonymous_variant	0.57	capreomycin
tlyA	1917984	c.45C>T	synonymous_variant	0.54	capreomycin
tlyA	1917985	c.46C>T	synonymous_variant	0.54	capreomycin
tlyA	1917993	c.54A>T	synonymous_variant	0.57	capreomycin
tlyA	1917996	c.57A>C	synonymous_variant	0.57	capreomycin
tlyA	1917999	c.60T>G	synonymous_variant	0.57	capreomycin
tlyA	1918038	c.99C>T	synonymous_variant	0.52	capreomycin
tlyA	1918050	c.111G>A	synonymous_variant	0.4	capreomycin
tlyA	1918422	c.483T>C	synonymous_variant	0.5	capreomycin
tlyA	1918446	c.507A>T	synonymous_variant	0.73	capreomycin
tlyA	1918457	p.Arg173Pro	missense_variant	0.74	capreomycin
tlyA	1918476	c.537A>C	synonymous_variant	0.81	capreomycin
tlyA	1918477	p.Leu180Met	missense_variant	0.84	capreomycin
tlyA	1918503	c.564G>A	synonymous_variant	0.79	capreomycin
tlyA	1918506	c.567A>G	synonymous_variant	0.76	capreomycin
tlyA	1918518	c.579C>G	synonymous_variant	0.6	capreomycin
tlyA	1918524	c.585T>C	synonymous_variant	0.57	capreomycin
tlyA	1918533	c.594C>G	synonymous_variant	0.38	capreomycin
bacA	2064897	c.-169C>G	upstream_gene_variant	0.26	kanamycin
					capreomycin
					streptomycin
					amikacin
bacA	2064907	c.-179G>A	upstream_gene_variant	0.28	kanamycin
					capreomycin
					streptomycin
					amikacin
bacA	2064912	c.-184A>G	upstream_gene_variant	0.29	kanamycin
					capreomycin
					streptomycin
					amikacin
bacA	2064933	c.-205A>G	upstream_gene_variant	0.38	kanamycin
					capreomycin
					streptomycin
					amikacin
bacA	2064936	c.-208C>G	upstream_gene_variant	0.38	kanamycin
					capreomycin
					streptomycin
					amikacin
bacA	2064943	c.-215T>C	upstream_gene_variant	0.43	kanamycin
					capreomycin
					streptomycin
					amikacin
bacA	2064951	c.-223C>G	upstream_gene_variant	0.41	kanamycin
					capreomycin
					streptomycin
					amikacin
bacA	2064969	c.-241T>C	upstream_gene_variant	0.42	kanamycin
					capreomycin
					streptomycin
					amikacin
bacA	2064972	c.-244T>C	upstream_gene_variant	0.41	kanamycin
					capreomycin
					streptomycin
					amikacin
bacA	2064979	c.-253_-251delGGCinsCGT	upstream_gene_variant	0.32	kanamycin
					capreomycin
					streptomycin
					amikacin
bacA	2064984	c.-256A>G	upstream_gene_variant	0.35	kanamycin
					capreomycin
					streptomycin
					amikacin
bacA	2064993	c.-265T>C	upstream_gene_variant	0.35	kanamycin
					capreomycin
					streptomycin
					amikacin
ndh	2101858	p.Ile395Met	missense_variant	0.55	isoniazid
					delamanid
					ethionamide
ndh	2101873	c.1170T>C	synonymous_variant	0.61	isoniazid
					delamanid
					ethionamide
ndh	2101876	c.1167C>G	synonymous_variant	0.62	isoniazid
					delamanid
					ethionamide
ndh	2101879	c.1164C>T	synonymous_variant	0.54	isoniazid	Not assoc w R - Interim
					delamanid
					ethionamide	Not assoc w R - Interim
ndh	2101888	p.Val385Leu	missense_variant	0.55	isoniazid
					delamanid
					ethionamide
ndh	2101891	c.1152C>G	synonymous_variant	0.55	isoniazid	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					ethionamide	Not assoc w R - Interim
ndh	2101894	c.1149T>C	synonymous_variant	0.55	isoniazid
					delamanid
					ethionamide
ndh	2101906	c.1137G>C	synonymous_variant	0.55	isoniazid
					delamanid
					ethionamide
ndh	2101912	c.1131G>C	synonymous_variant	0.53	isoniazid
					delamanid
					ethionamide
ndh	2101915	c.1128T>C	synonymous_variant	0.5	isoniazid	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					ethionamide	Not assoc w R - Interim
ndh	2101918	c.1123_1125delAGGinsCGA	synonymous_variant	0.5	isoniazid
					delamanid
					ethionamide
ndh	2101924	c.1119T>G	synonymous_variant	0.5	isoniazid
					delamanid
					ethionamide
ndh	2102230	c.813G>C	synonymous_variant	0.36	isoniazid
					delamanid
					ethionamide
ndh	2102242	c.801G>C	synonymous_variant	0.48	isoniazid
					delamanid
					ethionamide
ndh	2102245	p.Val266Glu	missense_variant	0.48	isoniazid
					delamanid
					ethionamide
ndh	2102259	p.Ser262Ala	missense_variant	0.48	isoniazid
					delamanid
					ethionamide
ndh	2102260	c.783C>T	synonymous_variant	0.41	isoniazid
					delamanid
					ethionamide
ndh	2102302	c.741G>C	synonymous_variant	0.36	isoniazid
					delamanid
					ethionamide
ndh	2102305	c.738T>C	synonymous_variant	0.29	isoniazid
					delamanid
					ethionamide
ndh	2102919	c.124C>T	synonymous_variant	0.33	isoniazid	Not assoc w R - Interim
					delamanid
					ethionamide	Not assoc w R - Interim
ndh	2102929	c.114T>C	synonymous_variant	0.32	isoniazid
					delamanid
					ethionamide
ndh	2102935	c.108C>T	synonymous_variant	0.32	isoniazid	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					ethionamide	Not assoc w R - Interim
ndh	2102938	p.Arg35His	missense_variant	0.35	isoniazid
					delamanid
					ethionamide
ndh	2102960	p.Asn28Thr	missense_variant	0.39	isoniazid
					delamanid
					ethionamide
ndh	2102962	c.81A>C	synonymous_variant	0.39	isoniazid
					delamanid
					ethionamide
ndh	2102965	c.78G>A	synonymous_variant	0.41	isoniazid
					delamanid
					ethionamide
ndh	2102977	c.66T>C	synonymous_variant	0.32	isoniazid
					delamanid
					ethionamide
katG	2154724	p.Arg463Leu	missense_variant	1.0	isoniazid	Not assoc w R
katG	2155691	c.421T>C	synonymous_variant	0.58	isoniazid
katG	2155704	c.408C>G	synonymous_variant	0.61	isoniazid
katG	2155716	c.396T>C	synonymous_variant	0.64	isoniazid
katG	2155736	p.Met126Leu	missense_variant	0.64	isoniazid
katG	2155740	p.Gly124Gln	missense_variant	0.62	isoniazid
katG	2155743	c.369G>A	synonymous_variant	0.65	isoniazid	Not assoc w R - Interim
katG	2155758	c.354C>T	synonymous_variant	0.61	isoniazid
katG	2155764	p.His116Tyr	missense_variant	0.47	isoniazid	Uncertain significance
PPE35	2167983	p.Gly877Asp	missense_variant	1.0	pyrazinamide	Uncertain significance
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
kasA	2517941	c.-174C>G	upstream_gene_variant	0.66	isoniazid
kasA	2517950	c.-165C>G	upstream_gene_variant	0.66	isoniazid
kasA	2517965	c.-150C>T	upstream_gene_variant	0.48	isoniazid
kasA	2518019	c.-96A>G	upstream_gene_variant	0.35	isoniazid
kasA	2518025	c.-90G>C	upstream_gene_variant	0.33	isoniazid
kasA	2518031	c.-84G>T	upstream_gene_variant	0.27	isoniazid
kasA	2518034	c.-81T>C	upstream_gene_variant	0.27	isoniazid
kasA	2518035	c.-80C>G	upstream_gene_variant	0.28	isoniazid
kasA	2518041	c.-74T>C	upstream_gene_variant	0.26	isoniazid
kasA	2518049	c.-66G>C	upstream_gene_variant	0.27	isoniazid
kasA	2518132	c.18C>T	synonymous_variant	1.0	isoniazid
kasA	2518219	c.105T>C	synonymous_variant	0.43	isoniazid
kasA	2518220	c.106C>T	synonymous_variant	0.43	isoniazid
kasA	2518234	c.120G>A	synonymous_variant	0.47	isoniazid
kasA	2518339	c.225C>G	synonymous_variant	0.45	isoniazid
kasA	2518390	c.276A>C	synonymous_variant	0.37	isoniazid
kasA	2518394	c.280_282delCTAinsTTG	synonymous_variant	0.4	isoniazid
kasA	2518417	c.303G>T	synonymous_variant	0.32	isoniazid
kasA	2518462	c.348A>C	synonymous_variant	0.38	isoniazid
kasA	2518465	c.351T>C	synonymous_variant	0.36	isoniazid
kasA	2518468	c.354A>T	synonymous_variant	0.38	isoniazid
kasA	2518475	c.361A>C	synonymous_variant	0.44	isoniazid
kasA	2518480	c.366T>C	synonymous_variant	0.46	isoniazid
kasA	2518528	c.414C>G	synonymous_variant	0.47	isoniazid
kasA	2518561	c.447T>C	synonymous_variant	0.55	isoniazid
kasA	2518574	p.Ile154Val	missense_variant	0.52	isoniazid
kasA	2518579	c.465T>C	synonymous_variant	0.53	isoniazid
kasA	2518585	c.471G>A	synonymous_variant	0.55	isoniazid
kasA	2518588	c.474T>C	synonymous_variant	0.59	isoniazid
kasA	2518591	c.477G>T	synonymous_variant	0.64	isoniazid
kasA	2518603	c.489G>C	synonymous_variant	0.6	isoniazid
kasA	2518606	c.492G>C	synonymous_variant	0.6	isoniazid
kasA	2518609	p.Met165Ile	missense_variant	0.6	isoniazid
kasA	2518612	c.498C>T	synonymous_variant	0.6	isoniazid
kasA	2518636	c.522C>T	synonymous_variant	0.5	isoniazid
kasA	2518645	c.531G>C	synonymous_variant	0.47	isoniazid
kasA	2518666	c.552G>A	synonymous_variant	0.27	isoniazid
kasA	2518705	c.591T>C	synonymous_variant	0.38	isoniazid
kasA	2518717	c.603C>G	synonymous_variant	0.4	isoniazid
kasA	2518723	c.609G>A	synonymous_variant	0.45	isoniazid
kasA	2518747	c.633C>G	synonymous_variant	0.54	isoniazid
kasA	2518765	c.651G>A	synonymous_variant	0.59	isoniazid
kasA	2518768	c.654C>G	synonymous_variant	0.61	isoniazid
kasA	2518783	c.669T>C	synonymous_variant	0.56	isoniazid
kasA	2518792	c.678C>G	synonymous_variant	0.54	isoniazid
kasA	2518795	c.681C>G	synonymous_variant	0.56	isoniazid
kasA	2518816	c.702C>G	synonymous_variant	0.54	isoniazid
kasA	2518822	c.708C>G	synonymous_variant	0.47	isoniazid
kasA	2518825	c.711T>C	synonymous_variant	0.47	isoniazid
kasA	2518843	c.729T>G	synonymous_variant	0.34	isoniazid
kasA	2518846	c.732G>A	synonymous_variant	0.35	isoniazid
kasA	2518847	p.Leu245Met	missense_variant	0.35	isoniazid
kasA	2518853	p.Leu247Ile	missense_variant	0.35	isoniazid
ahpC	2726318	p.Glu42Asp	missense_variant	0.6	isoniazid
ahpC	2726324	c.132A>C	synonymous_variant	0.62	isoniazid
ahpC	2726327	c.135C>T	synonymous_variant	0.62	isoniazid
ahpC	2726348	c.156T>C	synonymous_variant	0.61	isoniazid
ahpC	2726357	c.165A>G	synonymous_variant	0.56	isoniazid	Not assoc w R - Interim
ahpC	2726366	c.174G>C	synonymous_variant	0.53	isoniazid
ahpC	2726372	c.180G>A	synonymous_variant	0.53	isoniazid
ahpC	2726375	c.183C>T	synonymous_variant	0.47	isoniazid
ahpC	2726378	c.186T>C	synonymous_variant	0.53	isoniazid
ahpC	2726393	c.201G>T	synonymous_variant	0.5	isoniazid
folC	2746999	c.600T>C	synonymous_variant	0.36	para-aminosalicylic_acid
folC	2747004	p.Ile199Val	missense_variant	0.43	para-aminosalicylic_acid
folC	2747026	c.573C>G	synonymous_variant	0.48	para-aminosalicylic_acid
folC	2747038	p.Ile187Leu	missense_variant	0.53	para-aminosalicylic_acid
folC	2747047	c.552C>T	synonymous_variant	0.55	para-aminosalicylic_acid
folC	2747059	p.Arg180Ser	missense_variant	0.56	para-aminosalicylic_acid
folC	2747062	c.537A>C	synonymous_variant	0.56	para-aminosalicylic_acid
folC	2747065	c.534C>T	synonymous_variant	0.56	para-aminosalicylic_acid
folC	2747086	c.513A>G	synonymous_variant	0.56	para-aminosalicylic_acid
folC	2747089	c.510G>C	synonymous_variant	0.54	para-aminosalicylic_acid
folC	2747104	c.495C>T	synonymous_variant	0.5	para-aminosalicylic_acid
folC	2747107	c.492G>C	synonymous_variant	0.45	para-aminosalicylic_acid
folC	2747110	c.489T>C	synonymous_variant	0.44	para-aminosalicylic_acid
folC	2747113	c.486C>G	synonymous_variant	0.42	para-aminosalicylic_acid
folC	2747302	c.297A>G	synonymous_variant	0.39	para-aminosalicylic_acid
folC	2747326	c.270_272delCCG	disruptive_inframe_deletion	0.48	para-aminosalicylic_acid
folC	2747332	c.266_267insTTC	disruptive_inframe_insertion	0.48	para-aminosalicylic_acid
folC	2747350	c.249C>T	synonymous_variant	0.57	para-aminosalicylic_acid
folC	2747359	c.240C>G	synonymous_variant	0.58	para-aminosalicylic_acid
folC	2747365	c.234G>C	synonymous_variant	0.58	para-aminosalicylic_acid
folC	2747371	c.228C>G	synonymous_variant	0.59	para-aminosalicylic_acid
folC	2747389	c.210G>C	synonymous_variant	0.62	para-aminosalicylic_acid
folC	2747395	c.204T>C	synonymous_variant	0.67	para-aminosalicylic_acid
folC	2747407	c.192T>C	synonymous_variant	0.59	para-aminosalicylic_acid
folC	2747414	p.Arg62Leu	missense_variant	0.57	para-aminosalicylic_acid
folC	2747419	c.180C>G	synonymous_variant	0.61	para-aminosalicylic_acid
folC	2747425	c.174C>G	synonymous_variant	0.67	para-aminosalicylic_acid
folC	2747428	c.171G>C	synonymous_variant	0.71	para-aminosalicylic_acid
folC	2747442	c.157T>C	synonymous_variant	0.83	para-aminosalicylic_acid
folC	2747443	c.156G>T	synonymous_variant	0.83	para-aminosalicylic_acid
folC	2747464	c.135G>C	synonymous_variant	0.88	para-aminosalicylic_acid
folC	2747467	p.Asp44Glu	missense_variant	0.86	para-aminosalicylic_acid
folC	2747477	p.Thr41Ser	missense_variant	0.81	para-aminosalicylic_acid
folC	2747479	c.120G>A	synonymous_variant	0.79	para-aminosalicylic_acid
folC	2747488	c.111C>A	synonymous_variant	0.76	para-aminosalicylic_acid
folC	2747491	c.108A>G	synonymous_variant	0.72	para-aminosalicylic_acid
folC	2747497	c.102C>G	synonymous_variant	0.68	para-aminosalicylic_acid
folC	2747500	c.99A>G	synonymous_variant	0.65	para-aminosalicylic_acid
folC	2747506	c.93G>A	synonymous_variant	0.68	para-aminosalicylic_acid
folC	2747509	c.90T>C	synonymous_variant	0.65	para-aminosalicylic_acid
folC	2747521	p.Ser26Ala	missense_variant	0.55	para-aminosalicylic_acid
Rv2477c	2782444	c.1599G>A	synonymous_variant	0.39	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782483	c.1560G>C	synonymous_variant	0.32	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782496	p.Asp516Thr	missense_variant	0.28	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2782501	c.1542T>C	synonymous_variant	0.27	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol
					amikacin	Not assoc w R - Interim
Rv2477c	2782504	c.1539G>A	synonymous_variant	0.27	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783122	c.921G>A	synonymous_variant	0.4	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783128	c.915C>T	synonymous_variant	0.38	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783131	c.912C>T	synonymous_variant	0.38	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783140	p.Thr301Ser	missense_variant	0.31	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783149	c.894G>C	synonymous_variant	0.34	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol
					amikacin	Not assoc w R - Interim
Rv2477c	2783181	c.862C>T	synonymous_variant	0.29	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783182	c.861C>G	synonymous_variant	0.29	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783185	c.858G>A	synonymous_variant	0.28	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783194	c.849A>G	synonymous_variant	0.29	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783278	c.765A>G	synonymous_variant	0.35	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783289	p.Leu252Ile	missense_variant	0.46	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783299	c.744A>G	synonymous_variant	0.47	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783302	c.741A>G	synonymous_variant	0.53	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783311	c.732T>C	synonymous_variant	0.6	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783332	c.711T>C	synonymous_variant	0.78	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783335	c.708C>G	synonymous_variant	0.82	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783350	c.693T>C	synonymous_variant	0.84	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783353	c.690T>C	synonymous_variant	0.85	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783359	c.684G>A	synonymous_variant	0.92	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783365	c.678C>T	synonymous_variant	0.87	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783374	c.669G>C	synonymous_variant	0.87	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783377	c.666C>G	synonymous_variant	0.83	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783395	c.648T>C	synonymous_variant	0.84	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783422	c.621T>G	synonymous_variant	0.82	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783427	p.Pro206Ala	missense_variant	0.81	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin	Uncertain significance
					ethambutol	Uncertain significance
					amikacin
Rv2477c	2783428	c.615C>T	synonymous_variant	0.81	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol
					amikacin	Not assoc w R - Interim
Rv2477c	2783440	c.603T>C	synonymous_variant	0.79	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783461	c.582T>C	synonymous_variant	0.76	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783467	c.576G>C	synonymous_variant	0.74	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783473	c.570A>G	synonymous_variant	0.75	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783499	c.544T>C	synonymous_variant	0.71	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783502	c.541T>C	synonymous_variant	0.7	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783512	c.531A>G	synonymous_variant	0.62	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783520	c.523T>C	synonymous_variant	0.62	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin
Rv2477c	2783527	c.516A>G	synonymous_variant	0.58	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783545	c.498C>T	synonymous_variant	0.54	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783548	c.495T>C	synonymous_variant	0.55	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783557	c.486T>C	synonymous_variant	0.57	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783563	c.480A>C	synonymous_variant	0.56	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783572	c.471A>C	synonymous_variant	0.54	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783578	c.465G>A	synonymous_variant	0.5	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783584	p.Ala153Pro	missense_variant	0.52	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783593	c.450T>C	synonymous_variant	0.53	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783605	c.438T>C	synonymous_variant	0.63	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783620	c.423C>G	synonymous_variant	0.71	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783626	p.Ala139Ser	missense_variant	0.76	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783632	c.411C>G	synonymous_variant	0.8	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783659	p.Glu128Asp	missense_variant	0.71	kanamycin	Uncertain significance
					levofloxacin	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					rifampicin	Uncertain significance
					ethambutol	Uncertain significance
					amikacin	Uncertain significance
Rv2477c	2783665	c.378A>G	synonymous_variant	0.72	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783674	c.369T>C	synonymous_variant	0.74	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783683	c.360A>G	synonymous_variant	0.78	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783700	p.Thr115Ser	missense_variant	0.77	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783719	c.324A>G	synonymous_variant	0.77	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783743	c.300C>G	synonymous_variant	0.66	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783749	p.Ile98Val	missense_variant	0.56	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783758	p.Asp95Glu	missense_variant	0.56	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783761	c.282G>C	synonymous_variant	0.55	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783766	p.Met93Leu	missense_variant	0.59	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783773	c.270A>G	synonymous_variant	0.52	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin
Rv2477c	2783779	c.264T>C	synonymous_variant	0.45	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783788	c.255T>C	synonymous_variant	0.38	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783791	c.252C>G	synonymous_variant	0.43	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783797	p.Asp82Glu	missense_variant	0.41	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783803	c.240C>T	synonymous_variant	0.42	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783809	c.234G>A	synonymous_variant	0.44	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783815	c.228A>G	synonymous_variant	0.44	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783824	c.219G>C	synonymous_variant	0.42	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783833	c.210G>C	synonymous_variant	0.53	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783836	c.207C>G	synonymous_variant	0.53	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783839	c.204C>G	synonymous_variant	0.51	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783848	c.195C>T	synonymous_variant	0.57	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783854	c.189C>T	synonymous_variant	0.54	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin
Rv2477c	2783857	c.186C>T	synonymous_variant	0.55	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783860	c.183T>C	synonymous_variant	0.55	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783883	c.160T>C	synonymous_variant	0.65	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783884	c.159T>A	synonymous_variant	0.65	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783914	c.129T>C	synonymous_variant	0.63	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783929	c.114C>T	synonymous_variant	0.64	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin
Rv2477c	2783938	c.105T>C	synonymous_variant	0.61	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783962	c.81T>C	synonymous_variant	0.64	kanamycin	Not assoc w R - Interim
					levofloxacin
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783974	c.69C>T	synonymous_variant	0.65	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783983	c.60C>T	synonymous_variant	0.62	kanamycin
					levofloxacin
					moxifloxacin
					streptomycin
					rifampicin
					ethambutol
					amikacin
Rv2477c	2783992	c.51T>C	synonymous_variant	0.58	kanamycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
					amikacin
pepQ	2859435	c.984C>T	synonymous_variant	0.8	bedaquiline
pepQ	2859435	c.984C>T	synonymous_variant	0.8	clofazimine
pepQ	2859438	c.981T>C	synonymous_variant	0.8	bedaquiline
pepQ	2859438	c.981T>C	synonymous_variant	0.8	clofazimine
pepQ	2859450	c.969C>G	synonymous_variant	0.71	bedaquiline
pepQ	2859450	c.969C>G	synonymous_variant	0.71	clofazimine
pepQ	2859468	c.951G>T	synonymous_variant	0.8	bedaquiline
pepQ	2859468	c.951G>T	synonymous_variant	0.8	clofazimine
pepQ	2859489	p.Val310Ala	missense_variant	0.75	bedaquiline
pepQ	2859489	p.Val310Ala	missense_variant	0.75	clofazimine
pepQ	2859492	c.927G>A	synonymous_variant	0.75	bedaquiline
pepQ	2859492	c.927G>A	synonymous_variant	0.75	clofazimine
pepQ	2859510	c.909T>C	synonymous_variant	0.68	bedaquiline
pepQ	2859510	c.909T>C	synonymous_variant	0.68	clofazimine
pepQ	2859525	c.894T>C	synonymous_variant	0.47	bedaquiline
pepQ	2859525	c.894T>C	synonymous_variant	0.47	clofazimine
pepQ	2859528	c.891T>A	synonymous_variant	0.47	bedaquiline
pepQ	2859528	c.891T>A	synonymous_variant	0.47	clofazimine
Rv2680	2996032	c.-73C>A	upstream_gene_variant	0.47	capreomycin
Rv2680	2996059	c.-46C>T	upstream_gene_variant	0.47	capreomycin
Rv2680	2996083	c.-22C>A	upstream_gene_variant	0.44	capreomycin
Rv2681	2996593	c.-146T>C	upstream_gene_variant	0.47	capreomycin
Rv2681	2996611	c.-128G>C	upstream_gene_variant	0.58	capreomycin
Rv2681	2996614	c.-125G>A	upstream_gene_variant	0.58	capreomycin
Rv2681	2996617	c.-122A>G	upstream_gene_variant	0.61	capreomycin
Rv2681	2996623	c.-116G>T	upstream_gene_variant	0.63	capreomycin
Rv2681	2996635	c.-104C>G	upstream_gene_variant	0.63	capreomycin
Rv2680	2996639	p.Leu179Val	missense_variant	0.63	capreomycin
Rv2680	2996645	p.Ala181Ser	missense_variant	0.63	capreomycin	Uncertain significance
Rv2681	2996650	c.-89T>C	upstream_gene_variant	0.64	capreomycin
Rv2680	2996654	p.Gln184Glu	missense_variant	0.61	capreomycin	Uncertain significance
Rv2681	2996674	c.-65G>C	upstream_gene_variant	0.7	capreomycin
Rv2681	2996683	c.-56G>C	upstream_gene_variant	0.59	capreomycin
Rv2681	2996686	c.-53C>G	upstream_gene_variant	0.55	capreomycin
Rv2681	2996689	c.-50C>T	upstream_gene_variant	0.53	capreomycin
Rv2681	2996698	c.-41A>G	upstream_gene_variant	0.48	capreomycin
Rv2681	2996701	c.-38C>G	upstream_gene_variant	0.44	capreomycin
Rv2681	2996704	c.-35G>T	upstream_gene_variant	0.42	capreomycin
Rv2680	2996717	p.Gly205Ser	missense_variant	0.36	capreomycin
Rv2681	2996722	c.-17G>A	upstream_gene_variant	0.33	capreomycin
Rv2681	2996750	p.Glu4Asp	missense_variant	0.25	capreomycin
Rv2681	2997092	c.354T>C	synonymous_variant	0.5	capreomycin
Rv2681	2997101	c.363T>C	synonymous_variant	0.45	capreomycin
Rv2681	2997110	c.372G>A	synonymous_variant	0.46	capreomycin	Not assoc w R - Interim
Rv2681	2997116	c.378T>C	synonymous_variant	0.48	capreomycin
Rv2681	2997128	c.390A>G	synonymous_variant	0.46	capreomycin
Rv2681	2997131	c.393G>C	synonymous_variant	0.44	capreomycin
Rv2681	2997134	c.396A>G	synonymous_variant	0.44	capreomycin
Rv2681	2997146	c.408G>A	synonymous_variant	0.42	capreomycin
Rv2681	2997149	c.411T>G	synonymous_variant	0.48	capreomycin
Rv2681	2997155	c.417G>A	synonymous_variant	0.41	capreomycin
Rv2681	2997158	c.420C>T	synonymous_variant	0.39	capreomycin
Rv2681	2997455	c.717T>C	synonymous_variant	0.25	capreomycin	Not assoc w R - Interim
Rv2681	2997464	c.726A>G	synonymous_variant	0.28	capreomycin
Rv2681	2997473	c.735C>T	synonymous_variant	0.38	capreomycin
Rv2681	2997476	c.738G>T	synonymous_variant	0.39	capreomycin
Rv2681	2997481	p.Gly248Ala	missense_variant	0.36	capreomycin
Rv2681	2997497	c.759C>T	synonymous_variant	0.36	capreomycin
Rv2681	2997509	c.771A>C	synonymous_variant	0.37	capreomycin
Rv2681	2997510	p.Ala258Thr	missense_variant	0.35	capreomycin
Rv2681	2997515	c.777T>C	synonymous_variant	0.36	capreomycin
Rv2681	2997521	c.783A>G	synonymous_variant	0.33	capreomycin
Rv2681	2997527	c.789C>A	synonymous_variant	0.34	capreomycin
Rv2681	2997548	c.810C>A	synonymous_variant	0.38	capreomycin
Rv2752c	3064632	c.1560C>T	synonymous_variant	0.93	levofloxacin	Not assoc w R
					moxifloxacin	Not assoc w R
					isoniazid	Not assoc w R
					rifampicin	Not assoc w R
					ethambutol	Not assoc w R
Rv2752c	3064953	c.1239C>G	synonymous_variant	0.47	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
Rv2752c	3064956	c.1236T>C	synonymous_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3064974	c.1218T>C	synonymous_variant	0.54	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3064980	c.1212C>G	synonymous_variant	0.56	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
Rv2752c	3064986	p.Met402His	missense_variant	0.56	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065013	c.1179G>C	synonymous_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065018	p.Asn392His	missense_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065028	c.1164G>C	synonymous_variant	0.45	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065031	c.1161G>A	synonymous_variant	0.48	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
Rv2752c	3065040	c.1152C>G	synonymous_variant	0.53	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
Rv2752c	3065051	c.1141C>T	synonymous_variant	0.47	levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol
Rv2752c	3065400	c.792A>G	synonymous_variant	0.26	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065403	c.789C>G	synonymous_variant	0.29	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065415	c.777G>A	synonymous_variant	0.36	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
Rv2752c	3065418	c.774A>G	synonymous_variant	0.39	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065430	c.762A>T	synonymous_variant	0.45	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065442	c.750T>C	synonymous_variant	0.55	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065463	c.729T>C	synonymous_variant	0.64	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065466	c.726G>C	synonymous_variant	0.64	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065481	c.711T>C	synonymous_variant	0.57	levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
Rv2752c	3065487	c.705T>G	synonymous_variant	0.48	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065490	c.702A>C	synonymous_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065493	c.699G>C	synonymous_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065511	c.681G>C	synonymous_variant	0.42	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065517	c.675C>G	synonymous_variant	0.35	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3065523	c.669C>T	synonymous_variant	0.35	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066249	c.-58C>T	upstream_gene_variant	0.44	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066255	c.-64C>G	upstream_gene_variant	0.47	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066269	c.-78A>C	upstream_gene_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066270	c.-79G>A	upstream_gene_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066282	c.-91G>C	upstream_gene_variant	0.46	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066285	c.-96_-94delGCCinsCCG	upstream_gene_variant	0.44	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066288	c.-97G>C	upstream_gene_variant	0.44	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066294	c.-103C>G	upstream_gene_variant	0.46	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066303	c.-112C>G	upstream_gene_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066306	c.-115T>C	upstream_gene_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066309	c.-118T>C	upstream_gene_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066313	c.-122T>C	upstream_gene_variant	0.53	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066336	c.-145C>T	upstream_gene_variant	0.55	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066360	c.-169T>C	upstream_gene_variant	0.47	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066363	c.-172G>A	upstream_gene_variant	0.47	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066366	c.-175C>G	upstream_gene_variant	0.47	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066369	c.-180_-178delAGCinsGCA	upstream_gene_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066390	c.-200_-199delCCinsGG	upstream_gene_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066398	c.-207G>T	upstream_gene_variant	0.4	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
Rv2752c	3066399	c.-210_-208delATTinsCTC	upstream_gene_variant	0.4	levofloxacin
					moxifloxacin
					isoniazid
					rifampicin
					ethambutol
thyX	3067304	p.Glu214Ala	missense_variant	0.45	para-aminosalicylic_acid
thyX	3067310	c.636C>G	synonymous_variant	0.4	para-aminosalicylic_acid
thyX	3067316	c.630A>G	synonymous_variant	0.4	para-aminosalicylic_acid
thyX	3067321	c.625C>A	synonymous_variant	0.4	para-aminosalicylic_acid
thyX	3067325	c.621A>G	synonymous_variant	0.41	para-aminosalicylic_acid
thyX	3067328	c.618G>C	synonymous_variant	0.45	para-aminosalicylic_acid
thyX	3067349	c.597G>A	synonymous_variant	0.55	para-aminosalicylic_acid
thyX	3067355	c.591A>G	synonymous_variant	0.57	para-aminosalicylic_acid
thyX	3067373	c.573C>G	synonymous_variant	0.6	para-aminosalicylic_acid
thyX	3067385	c.561C>T	synonymous_variant	0.58	para-aminosalicylic_acid
thyX	3067391	c.555G>C	synonymous_variant	0.6	para-aminosalicylic_acid
thyX	3067394	c.552G>C	synonymous_variant	0.61	para-aminosalicylic_acid
thyX	3067415	c.531C>T	synonymous_variant	0.65	para-aminosalicylic_acid
thyX	3067423	c.523C>T	synonymous_variant	0.66	para-aminosalicylic_acid
thyX	3067427	c.519G>A	synonymous_variant	0.62	para-aminosalicylic_acid
thyX	3067439	c.507A>G	synonymous_variant	0.48	para-aminosalicylic_acid
thyX	3067451	c.495G>A	synonymous_variant	0.39	para-aminosalicylic_acid
thyX	3067457	c.487_489delCGCinsAGG	synonymous_variant	0.33	para-aminosalicylic_acid
thyX	3067631	c.315C>G	synonymous_variant	0.35	para-aminosalicylic_acid
thyX	3067652	c.294T>C	synonymous_variant	0.31	para-aminosalicylic_acid
thyX	3067664	c.282C>T	synonymous_variant	0.39	para-aminosalicylic_acid
thyX	3067676	c.270C>T	synonymous_variant	0.33	para-aminosalicylic_acid
thyX	3067679	c.267C>T	synonymous_variant	0.28	para-aminosalicylic_acid
thyX	3067685	c.261A>G	synonymous_variant	0.35	para-aminosalicylic_acid
thyX	3067694	c.252G>C	synonymous_variant	0.39	para-aminosalicylic_acid
thyX	3067721	c.225T>C	synonymous_variant	0.39	para-aminosalicylic_acid
thyX	3067727	c.219A>C	synonymous_variant	0.43	para-aminosalicylic_acid
thyX	3067742	c.204A>G	synonymous_variant	0.54	para-aminosalicylic_acid
thyX	3067762	c.184C>A	synonymous_variant	0.55	para-aminosalicylic_acid
thyX	3067765	p.Leu61Ile	missense_variant	0.54	para-aminosalicylic_acid
thyX	3067774	p.Ala58Thr	missense_variant	0.54	para-aminosalicylic_acid
thyX	3067781	c.165C>A	synonymous_variant	0.46	para-aminosalicylic_acid
thyX	3067787	p.Lys53Arg	missense_variant	0.39	para-aminosalicylic_acid
thyX	3067790	c.156C>G	synonymous_variant	0.41	para-aminosalicylic_acid
thyX	3067793	c.153T>C	synonymous_variant	0.41	para-aminosalicylic_acid
thyX	3067796	c.150C>G	synonymous_variant	0.41	para-aminosalicylic_acid
thyX	3067811	c.135G>A	synonymous_variant	0.41	para-aminosalicylic_acid
thyX	3067814	c.132T>C	synonymous_variant	0.41	para-aminosalicylic_acid
thyA	3073893	c.579C>G	synonymous_variant	0.44	para-aminosalicylic_acid
thyA	3073929	c.543T>C	synonymous_variant	0.67	para-aminosalicylic_acid
thyA	3073932	c.540C>T	synonymous_variant	0.6	para-aminosalicylic_acid
thyA	3073950	c.522G>T	synonymous_variant	0.56	para-aminosalicylic_acid
thyA	3073953	c.519T>G	synonymous_variant	0.56	para-aminosalicylic_acid
thyA	3073956	c.516G>C	synonymous_variant	0.56	para-aminosalicylic_acid
thyA	3073959	c.513T>C	synonymous_variant	0.53	para-aminosalicylic_acid
thyA	3073962	c.510G>A	synonymous_variant	0.5	para-aminosalicylic_acid
thyA	3073977	c.495A>G	synonymous_variant	0.5	para-aminosalicylic_acid
thyA	3073980	c.492C>T	synonymous_variant	0.53	para-aminosalicylic_acid
thyA	3073983	c.489C>G	synonymous_variant	0.57	para-aminosalicylic_acid
thyA	3073989	c.483T>C	synonymous_variant	0.54	para-aminosalicylic_acid
thyA	3074004	p.Asp156Gly	missense_variant	0.42	para-aminosalicylic_acid
thyA	3074028	c.444G>C	synonymous_variant	0.3	para-aminosalicylic_acid
thyA	3074031	c.441T>C	synonymous_variant	0.28	para-aminosalicylic_acid
thyA	3074034	c.438T>C	synonymous_variant	0.28	para-aminosalicylic_acid
thyA	3074037	c.435C>G	synonymous_variant	0.28	para-aminosalicylic_acid
thyA	3074040	c.432G>C	synonymous_variant	0.29	para-aminosalicylic_acid
thyA	3074045	c.427C>T	synonymous_variant	0.27	para-aminosalicylic_acid
thyA	3074053	p.Arg140Gln	missense_variant	0.26	para-aminosalicylic_acid
thyA	3074055	p.Glu139Pro	missense_variant	0.26	para-aminosalicylic_acid
thyA	3074061	c.411A>G	synonymous_variant	0.32	para-aminosalicylic_acid
thyA	3074082	c.390G>C	synonymous_variant	0.32	para-aminosalicylic_acid
ald	3086750	c.-70A>C	upstream_gene_variant	1.0	cycloserine
ald	3086788	c.-32T>C	upstream_gene_variant	1.0	cycloserine
whiB7	3568896	c.-217C>T	upstream_gene_variant	1.0	kanamycin
					amikacin
					streptomycin	Uncertain significance
whiB7	3569195	c.-516G>T	upstream_gene_variant	0.69	kanamycin
					amikacin
					streptomycin
whiB7	3569201	c.-522G>A	upstream_gene_variant	0.73	kanamycin
					amikacin
					streptomycin
whiB7	3569208	c.-529T>C	upstream_gene_variant	0.69	kanamycin
					amikacin
					streptomycin
whiB7	3569211	c.-533_-532delTAinsGG	upstream_gene_variant	0.69	kanamycin
					amikacin
					streptomycin
whiB7	3569220	c.-541C>G	upstream_gene_variant	0.69	kanamycin
					amikacin
					streptomycin
whiB7	3569245	c.-566C>G	upstream_gene_variant	0.62	kanamycin
					amikacin
					streptomycin
whiB7	3569250	c.-571T>G	upstream_gene_variant	0.56	kanamycin
					amikacin
					streptomycin
lpqB	3623411	c.1500T>G	synonymous_variant	0.42	rifampicin
lpqB	3623411	c.1500T>G	synonymous_variant	0.42	bedaquiline
lpqB	3623424	p.Ser496Tyr	missense_variant	0.52	rifampicin
lpqB	3623424	p.Ser496Tyr	missense_variant	0.52	bedaquiline
lpqB	3623428	c.1483T>C	synonymous_variant	0.57	rifampicin
lpqB	3623428	c.1483T>C	synonymous_variant	0.57	bedaquiline
lpqB	3623443	p.Ser490Thr	missense_variant	0.48	rifampicin
lpqB	3623443	p.Ser490Thr	missense_variant	0.48	bedaquiline
lpqB	3623444	c.1467T>C	synonymous_variant	0.47	rifampicin
lpqB	3623444	c.1467T>C	synonymous_variant	0.47	bedaquiline
lpqB	3623450	c.1461G>C	synonymous_variant	0.45	rifampicin
lpqB	3623450	c.1461G>C	synonymous_variant	0.45	bedaquiline
lpqB	3623456	c.1455T>C	synonymous_variant	0.45	rifampicin
lpqB	3623456	c.1455T>C	synonymous_variant	0.45	bedaquiline
lpqB	3623461	c.1450C>T	synonymous_variant	0.45	rifampicin
lpqB	3623461	c.1450C>T	synonymous_variant	0.45	bedaquiline
lpqB	3623465	c.1446G>A	synonymous_variant	0.45	rifampicin	Not assoc w R - Interim
lpqB	3623465	c.1446G>A	synonymous_variant	0.45	bedaquiline
lpqB	3623468	c.1443T>G	synonymous_variant	0.45	rifampicin	Not assoc w R - Interim
lpqB	3623468	c.1443T>G	synonymous_variant	0.45	bedaquiline
lpqB	3623471	c.1440C>T	synonymous_variant	0.45	rifampicin
lpqB	3623471	c.1440C>T	synonymous_variant	0.45	bedaquiline
lpqB	3623492	c.1419T>C	synonymous_variant	0.53	rifampicin
lpqB	3623492	c.1419T>C	synonymous_variant	0.53	bedaquiline
lpqB	3623510	c.1401C>A	synonymous_variant	0.38	rifampicin
lpqB	3623510	c.1401C>A	synonymous_variant	0.38	bedaquiline
lpqB	3623516	c.1395C>G	synonymous_variant	0.33	rifampicin
lpqB	3623516	c.1395C>G	synonymous_variant	0.33	bedaquiline
lpqB	3623993	c.918C>T	synonymous_variant	0.4	rifampicin
lpqB	3623993	c.918C>T	synonymous_variant	0.4	bedaquiline
lpqB	3624002	c.909G>C	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
lpqB	3624002	c.909G>C	synonymous_variant	0.42	bedaquiline	Not assoc w R - Interim
lpqB	3624008	c.903T>C	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
lpqB	3624008	c.903T>C	synonymous_variant	0.42	bedaquiline
lpqB	3624014	c.897T>C	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
lpqB	3624014	c.897T>C	synonymous_variant	0.41	bedaquiline
lpqB	3624018	p.Thr298Asn	missense_variant	0.42	rifampicin
lpqB	3624018	p.Thr298Asn	missense_variant	0.42	bedaquiline
lpqB	3624023	c.888G>C	synonymous_variant	0.45	rifampicin
lpqB	3624023	c.888G>C	synonymous_variant	0.45	bedaquiline
lpqB	3624028	p.Glu295Gln	missense_variant	0.5	rifampicin
lpqB	3624028	p.Glu295Gln	missense_variant	0.5	bedaquiline
lpqB	3624032	c.879T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
lpqB	3624032	c.879T>C	synonymous_variant	0.56	bedaquiline	Not assoc w R - Interim
lpqB	3624037	c.874A>C	synonymous_variant	0.54	rifampicin
lpqB	3624037	c.874A>C	synonymous_variant	0.54	bedaquiline
lpqB	3624041	p.Glu290Asp	missense_variant	0.54	rifampicin
lpqB	3624041	p.Glu290Asp	missense_variant	0.54	bedaquiline
lpqB	3624044	c.867G>C	synonymous_variant	0.58	rifampicin
lpqB	3624044	c.867G>C	synonymous_variant	0.58	bedaquiline
lpqB	3624064	p.Asn283Asp	missense_variant	0.53	rifampicin
lpqB	3624064	p.Asn283Asp	missense_variant	0.53	bedaquiline
lpqB	3624080	c.829_831delAGGinsCGC	synonymous_variant	0.4	rifampicin
lpqB	3624080	c.829_831delAGGinsCGC	synonymous_variant	0.4	bedaquiline
lpqB	3624632	c.279G>C	synonymous_variant	1.0	rifampicin
lpqB	3624632	c.279G>C	synonymous_variant	1.0	bedaquiline
lpqB	3624646	c.265T>C	synonymous_variant	0.94	rifampicin
lpqB	3624646	c.265T>C	synonymous_variant	0.94	bedaquiline
lpqB	3624649	c.262T>C	synonymous_variant	0.94	rifampicin
lpqB	3624649	c.262T>C	synonymous_variant	0.94	bedaquiline
lpqB	3624656	c.255C>T	synonymous_variant	0.95	rifampicin
lpqB	3624656	c.255C>T	synonymous_variant	0.95	bedaquiline
lpqB	3624680	c.231T>C	synonymous_variant	0.96	rifampicin
lpqB	3624680	c.231T>C	synonymous_variant	0.96	bedaquiline
lpqB	3624686	p.Glu75Gln	missense_variant	0.96	rifampicin
lpqB	3624686	p.Glu75Gln	missense_variant	0.96	bedaquiline
lpqB	3624698	c.213G>A	synonymous_variant	0.85	rifampicin
lpqB	3624698	c.213G>A	synonymous_variant	0.85	bedaquiline
lpqB	3624701	c.210T>G	synonymous_variant	0.85	rifampicin
lpqB	3624701	c.210T>G	synonymous_variant	0.85	bedaquiline
lpqB	3624704	c.207G>C	synonymous_variant	0.85	rifampicin
lpqB	3624704	c.207G>C	synonymous_variant	0.85	bedaquiline
lpqB	3624722	c.189C>G	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
lpqB	3624722	c.189C>G	synonymous_variant	0.78	bedaquiline	Not assoc w R - Interim
lpqB	3624734	c.177A>C	synonymous_variant	0.68	rifampicin
lpqB	3624734	c.177A>C	synonymous_variant	0.68	bedaquiline
lpqB	3624737	c.174C>G	synonymous_variant	0.57	rifampicin
lpqB	3624737	c.174C>G	synonymous_variant	0.57	bedaquiline
mtrB	3625222	c.1392T>C	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
mtrB	3625222	c.1392T>C	synonymous_variant	0.58	bedaquiline
lpqB	3625240	c.-330T>C	upstream_gene_variant	0.67	rifampicin
lpqB	3625240	c.-330T>C	upstream_gene_variant	0.67	bedaquiline
lpqB	3625243	c.-333T>C	upstream_gene_variant	0.67	rifampicin
lpqB	3625243	c.-333T>C	upstream_gene_variant	0.67	bedaquiline
lpqB	3625246	c.-336G>A	upstream_gene_variant	0.67	rifampicin
lpqB	3625246	c.-336G>A	upstream_gene_variant	0.67	bedaquiline
mtrB	3625252	c.1362G>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
mtrB	3625252	c.1362G>C	synonymous_variant	0.67	bedaquiline
lpqB	3625255	c.-345T>C	upstream_gene_variant	0.66	rifampicin
lpqB	3625255	c.-345T>C	upstream_gene_variant	0.66	bedaquiline
lpqB	3625258	c.-348G>C	upstream_gene_variant	0.67	rifampicin
lpqB	3625258	c.-348G>C	upstream_gene_variant	0.67	bedaquiline
mtrB	3625267	c.1347T>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
mtrB	3625267	c.1347T>C	synonymous_variant	0.69	bedaquiline
lpqB	3625270	c.-360G>C	upstream_gene_variant	0.71	rifampicin
lpqB	3625270	c.-360G>C	upstream_gene_variant	0.71	bedaquiline
lpqB	3625273	c.-363C>G	upstream_gene_variant	0.69	rifampicin
lpqB	3625273	c.-363C>G	upstream_gene_variant	0.69	bedaquiline
lpqB	3625285	c.-375G>C	upstream_gene_variant	0.68	rifampicin
lpqB	3625285	c.-375G>C	upstream_gene_variant	0.68	bedaquiline
lpqB	3625291	c.-381A>G	upstream_gene_variant	0.7	rifampicin
lpqB	3625291	c.-381A>G	upstream_gene_variant	0.7	bedaquiline
mtrB	3625321	c.1293A>G	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
mtrB	3625321	c.1293A>G	synonymous_variant	0.6	bedaquiline	Not assoc w R - Interim
lpqB	3625327	c.-417A>G	upstream_gene_variant	0.58	rifampicin
lpqB	3625327	c.-417A>G	upstream_gene_variant	0.58	bedaquiline
lpqB	3625333	c.-423C>T	upstream_gene_variant	0.56	rifampicin
lpqB	3625333	c.-423C>T	upstream_gene_variant	0.56	bedaquiline
lpqB	3625345	c.-435T>C	upstream_gene_variant	0.56	rifampicin
lpqB	3625345	c.-435T>C	upstream_gene_variant	0.56	bedaquiline
mtrB	3625351	c.1263T>C	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
mtrB	3625351	c.1263T>C	synonymous_variant	0.54	bedaquiline
lpqB	3625357	c.-447T>C	upstream_gene_variant	0.52	rifampicin
lpqB	3625357	c.-447T>C	upstream_gene_variant	0.52	bedaquiline
lpqB	3625489	c.-579A>C	upstream_gene_variant	0.32	rifampicin
lpqB	3625489	c.-579A>C	upstream_gene_variant	0.32	bedaquiline
mtrB	3625497	c.1117T>C	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
mtrB	3625497	c.1117T>C	synonymous_variant	0.38	bedaquiline
mtrB	3625503	p.Val371Leu	missense_variant	0.42	rifampicin
mtrB	3625503	p.Val371Leu	missense_variant	0.42	bedaquiline
lpqB	3625510	c.-600T>G	upstream_gene_variant	0.44	rifampicin
lpqB	3625510	c.-600T>G	upstream_gene_variant	0.44	bedaquiline
lpqB	3625513	c.-603G>C	upstream_gene_variant	0.52	rifampicin
lpqB	3625513	c.-603G>C	upstream_gene_variant	0.52	bedaquiline
lpqB	3625525	c.-615G>C	upstream_gene_variant	0.6	rifampicin
lpqB	3625525	c.-615G>C	upstream_gene_variant	0.6	bedaquiline
lpqB	3625528	c.-618G>C	upstream_gene_variant	0.6	rifampicin
lpqB	3625528	c.-618G>C	upstream_gene_variant	0.6	bedaquiline
lpqB	3625537	c.-627T>C	upstream_gene_variant	0.61	rifampicin
lpqB	3625537	c.-627T>C	upstream_gene_variant	0.61	bedaquiline
lpqB	3625543	c.-633G>C	upstream_gene_variant	0.59	rifampicin
lpqB	3625543	c.-633G>C	upstream_gene_variant	0.59	bedaquiline
mtrB	3625569	c.1045T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
mtrB	3625569	c.1045T>C	synonymous_variant	0.56	bedaquiline
lpqB	3625579	c.-669A>C	upstream_gene_variant	0.57	rifampicin
lpqB	3625579	c.-669A>C	upstream_gene_variant	0.57	bedaquiline
lpqB	3625588	c.-678G>A	upstream_gene_variant	0.53	rifampicin
lpqB	3625588	c.-678G>A	upstream_gene_variant	0.53	bedaquiline
mtrB	3625592	p.Ser341Asn	missense_variant	0.52	rifampicin
mtrB	3625592	p.Ser341Asn	missense_variant	0.52	bedaquiline
lpqB	3625594	c.-684T>C	upstream_gene_variant	0.52	rifampicin
lpqB	3625594	c.-684T>C	upstream_gene_variant	0.52	bedaquiline
lpqB	3625602	c.-692T>C	upstream_gene_variant	0.55	rifampicin
lpqB	3625602	c.-692T>C	upstream_gene_variant	0.55	bedaquiline
lpqB	3625612	c.-702G>C	upstream_gene_variant	0.55	rifampicin
lpqB	3625612	c.-702G>C	upstream_gene_variant	0.55	bedaquiline
mtrB	3625623	p.Thr331Ala	missense_variant	0.5	rifampicin
mtrB	3625623	p.Thr331Ala	missense_variant	0.5	bedaquiline
lpqB	3625630	c.-722_-720delCTCinsTTG	upstream_gene_variant	0.38	rifampicin
lpqB	3625630	c.-722_-720delCTCinsTTG	upstream_gene_variant	0.38	bedaquiline
mtrB	3625638	p.Ala326Ser	missense_variant	0.43	rifampicin
mtrB	3625638	p.Ala326Ser	missense_variant	0.43	bedaquiline
lpqB	3625648	c.-738T>C	upstream_gene_variant	0.5	rifampicin
lpqB	3625648	c.-738T>C	upstream_gene_variant	0.5	bedaquiline
mtrB	3625656	c.958T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
mtrB	3625656	c.958T>C	synonymous_variant	0.56	bedaquiline	Not assoc w R - Interim
lpqB	3625663	c.-753G>C	upstream_gene_variant	0.53	rifampicin
lpqB	3625663	c.-753G>C	upstream_gene_variant	0.53	bedaquiline
lpqB	3625675	c.-765G>C	upstream_gene_variant	0.62	rifampicin
lpqB	3625675	c.-765G>C	upstream_gene_variant	0.62	bedaquiline
lpqB	3625690	c.-780T>C	upstream_gene_variant	0.61	rifampicin
lpqB	3625690	c.-780T>C	upstream_gene_variant	0.61	bedaquiline
lpqB	3625696	c.-786A>G	upstream_gene_variant	0.58	rifampicin
lpqB	3625696	c.-786A>G	upstream_gene_variant	0.58	bedaquiline
mtrB	3625699	c.915C>T	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
mtrB	3625699	c.915C>T	synonymous_variant	0.6	bedaquiline
mtrB	3625720	c.894G>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
mtrB	3625720	c.894G>C	synonymous_variant	0.61	bedaquiline
lpqB	3625723	c.-813C>T	upstream_gene_variant	0.59	rifampicin
lpqB	3625723	c.-813C>T	upstream_gene_variant	0.59	bedaquiline
lpqB	3625731	c.-821C>T	upstream_gene_variant	0.68	rifampicin
lpqB	3625731	c.-821C>T	upstream_gene_variant	0.68	bedaquiline
mtrB	3625744	c.870G>A	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
mtrB	3625744	c.870G>A	synonymous_variant	0.68	bedaquiline
mtrB	3625747	c.867G>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
mtrB	3625747	c.867G>C	synonymous_variant	0.71	bedaquiline
mtrB	3625753	p.Ala287Thr	missense_variant	0.68	rifampicin	Uncertain significance
mtrB	3625753	p.Ala287Thr	missense_variant	0.68	bedaquiline
mtrB	3625765	c.849C>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
mtrB	3625765	c.849C>G	synonymous_variant	0.69	bedaquiline
mtrB	3625774	c.840G>A	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
mtrB	3625774	c.840G>A	synonymous_variant	0.69	bedaquiline
mtrB	3625806	c.808A>C	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
mtrB	3625806	c.808A>C	synonymous_variant	0.73	bedaquiline
mtrB	3625807	c.807C>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
mtrB	3625807	c.807C>G	synonymous_variant	0.75	bedaquiline
lpqB	3625828	c.-918G>C	upstream_gene_variant	0.82	rifampicin
lpqB	3625828	c.-918G>C	upstream_gene_variant	0.82	bedaquiline
mtrB	3625852	c.762A>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
mtrB	3625852	c.762A>G	synonymous_variant	0.83	bedaquiline
mtrB	3625867	c.747A>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
mtrB	3625867	c.747A>G	synonymous_variant	0.75	bedaquiline
mtrB	3625912	c.702G>C	synonymous_variant	0.67	rifampicin
mtrB	3625912	c.702G>C	synonymous_variant	0.67	bedaquiline
mtrB	3625915	c.699G>T	synonymous_variant	0.65	rifampicin
mtrB	3625915	c.699G>T	synonymous_variant	0.65	bedaquiline
mtrB	3625927	c.687T>C	synonymous_variant	0.58	rifampicin
mtrB	3625927	c.687T>C	synonymous_variant	0.58	bedaquiline
mtrB	3625936	c.678C>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
mtrB	3625936	c.678C>G	synonymous_variant	0.55	bedaquiline
mtrB	3625942	p.Val224Leu	missense_variant	0.51	rifampicin
mtrB	3625942	p.Val224Leu	missense_variant	0.51	bedaquiline
mtrB	3625945	c.669A>G	synonymous_variant	0.51	rifampicin
mtrB	3625945	c.669A>G	synonymous_variant	0.51	bedaquiline
mtrB	3625950	c.664C>T	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
mtrB	3625950	c.664C>T	synonymous_variant	0.52	bedaquiline
mtrB	3625951	c.663A>G	synonymous_variant	0.5	rifampicin
mtrB	3625951	c.663A>G	synonymous_variant	0.5	bedaquiline
mtrB	3625956	c.658C>T	synonymous_variant	0.53	rifampicin
mtrB	3625956	c.658C>T	synonymous_variant	0.53	bedaquiline
mtrB	3625977	p.Gly213Ser	missense_variant	0.55	rifampicin
mtrB	3625977	p.Gly213Ser	missense_variant	0.55	bedaquiline
mtrB	3625978	c.636T>C	synonymous_variant	0.55	rifampicin
mtrB	3625978	c.636T>C	synonymous_variant	0.55	bedaquiline
mtrB	3625987	c.627G>T	synonymous_variant	0.57	rifampicin
mtrB	3625987	c.627G>T	synonymous_variant	0.57	bedaquiline
mtrB	3625993	c.621G>C	synonymous_variant	0.57	rifampicin
mtrB	3625993	c.621G>C	synonymous_variant	0.57	bedaquiline
mtrB	3626070	p.Ile182Val	missense_variant	0.43	rifampicin
mtrB	3626070	p.Ile182Val	missense_variant	0.43	bedaquiline
mtrB	3626077	c.537C>G	synonymous_variant	0.46	rifampicin
mtrB	3626077	c.537C>G	synonymous_variant	0.46	bedaquiline
mtrB	3626083	c.531G>T	synonymous_variant	0.52	rifampicin
mtrB	3626083	c.531G>T	synonymous_variant	0.52	bedaquiline
mtrB	3626092	c.522T>C	synonymous_variant	0.48	rifampicin
mtrB	3626092	c.522T>C	synonymous_variant	0.48	bedaquiline
mtrB	3626095	p.Glu173Asp	missense_variant	0.46	rifampicin
mtrB	3626095	p.Glu173Asp	missense_variant	0.46	bedaquiline
mtrB	3626101	p.Gln171His	missense_variant	0.52	rifampicin
mtrB	3626101	p.Gln171His	missense_variant	0.52	bedaquiline
mtrB	3626116	c.498G>A	synonymous_variant	0.52	rifampicin
mtrB	3626116	c.498G>A	synonymous_variant	0.52	bedaquiline
mtrB	3626119	c.495C>T	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
mtrB	3626119	c.495C>T	synonymous_variant	0.5	bedaquiline
mtrB	3626122	c.492C>T	synonymous_variant	0.5	rifampicin
mtrB	3626122	c.492C>T	synonymous_variant	0.5	bedaquiline
mtrB	3626131	c.483G>T	synonymous_variant	0.48	rifampicin
mtrB	3626131	c.483G>T	synonymous_variant	0.48	bedaquiline
mtrB	3626308	c.306T>C	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
mtrB	3626308	c.306T>C	synonymous_variant	0.31	bedaquiline
mtrB	3626329	c.285G>A	synonymous_variant	0.44	rifampicin
mtrB	3626329	c.285G>A	synonymous_variant	0.44	bedaquiline
mtrB	3626344	c.270G>A	synonymous_variant	0.54	rifampicin
mtrB	3626344	c.270G>A	synonymous_variant	0.54	bedaquiline
mtrB	3626357	p.Thr86Gly	missense_variant	0.62	rifampicin
mtrB	3626357	p.Thr86Gly	missense_variant	0.62	bedaquiline
mtrB	3626362	c.252A>G	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
mtrB	3626362	c.252A>G	synonymous_variant	0.56	bedaquiline
mtrB	3626377	c.237C>T	synonymous_variant	0.61	rifampicin
mtrB	3626377	c.237C>T	synonymous_variant	0.61	bedaquiline
mtrB	3626381	p.Ile78Thr	missense_variant	0.62	rifampicin
mtrB	3626381	p.Ile78Thr	missense_variant	0.62	bedaquiline
mtrB	3626390	p.Arg75Lys	missense_variant	0.66	rifampicin
mtrB	3626390	p.Arg75Lys	missense_variant	0.66	bedaquiline
mtrB	3626398	p.Ile72Val	missense_variant	0.64	rifampicin
mtrB	3626398	p.Ile72Val	missense_variant	0.64	bedaquiline
mtrB	3626410	c.204T>C	synonymous_variant	0.65	rifampicin
mtrB	3626410	c.204T>C	synonymous_variant	0.65	bedaquiline
mtrB	3626705	c.-92G>T	upstream_gene_variant	0.5	rifampicin
mtrB	3626705	c.-92G>T	upstream_gene_variant	0.5	bedaquiline
mtrB	3626711	c.-98T>C	upstream_gene_variant	0.45	rifampicin
mtrB	3626711	c.-98T>C	upstream_gene_variant	0.45	bedaquiline
mtrA	3626741	c.609C>G	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
mtrA	3626741	c.609C>G	synonymous_variant	0.52	bedaquiline
mtrB	3626744	c.-131G>C	upstream_gene_variant	0.48	rifampicin
mtrB	3626744	c.-131G>C	upstream_gene_variant	0.48	bedaquiline
mtrB	3626750	c.-137T>C	upstream_gene_variant	0.59	rifampicin
mtrB	3626750	c.-137T>C	upstream_gene_variant	0.59	bedaquiline
mtrA	3626759	c.591T>C	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
mtrA	3626759	c.591T>C	synonymous_variant	0.58	bedaquiline
mtrB	3626774	c.-163_-161delAGGinsCGC	upstream_gene_variant	0.44	rifampicin
mtrB	3626774	c.-163_-161delAGGinsCGC	upstream_gene_variant	0.44	bedaquiline
mtrB	3626780	c.-167T>C	upstream_gene_variant	0.44	rifampicin
mtrB	3626780	c.-167T>C	upstream_gene_variant	0.44	bedaquiline
mtrB	3626783	c.-170C>G	upstream_gene_variant	0.44	rifampicin
mtrB	3626783	c.-170C>G	upstream_gene_variant	0.44	bedaquiline
mtrA	3626786	c.564A>G	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
mtrA	3626786	c.564A>G	synonymous_variant	0.44	bedaquiline
mtrB	3626798	c.-185T>A	upstream_gene_variant	0.4	rifampicin
mtrB	3626798	c.-185T>A	upstream_gene_variant	0.4	bedaquiline
mtrB	3626804	c.-191A>C	upstream_gene_variant	0.49	rifampicin
mtrB	3626804	c.-191A>C	upstream_gene_variant	0.49	bedaquiline
mtrB	3626849	c.-236C>G	upstream_gene_variant	0.57	rifampicin
mtrB	3626849	c.-236C>G	upstream_gene_variant	0.57	bedaquiline
mtrB	3626858	c.-245A>G	upstream_gene_variant	0.54	rifampicin
mtrB	3626858	c.-245A>G	upstream_gene_variant	0.54	bedaquiline
mtrB	3626866	c.-253T>C	upstream_gene_variant	0.57	rifampicin
mtrB	3626866	c.-253T>C	upstream_gene_variant	0.57	bedaquiline
mtrB	3626876	c.-263A>G	upstream_gene_variant	0.54	rifampicin
mtrB	3626876	c.-263A>G	upstream_gene_variant	0.54	bedaquiline
mtrB	3626885	c.-272A>G	upstream_gene_variant	0.5	rifampicin
mtrB	3626885	c.-272A>G	upstream_gene_variant	0.5	bedaquiline
mtrB	3626890	c.-277T>C	upstream_gene_variant	0.48	rifampicin
mtrB	3626890	c.-277T>C	upstream_gene_variant	0.48	bedaquiline
mtrB	3626891	c.-278G>C	upstream_gene_variant	0.52	rifampicin
mtrB	3626891	c.-278G>C	upstream_gene_variant	0.52	bedaquiline
mtrB	3626903	c.-290T>A	upstream_gene_variant	0.5	rifampicin
mtrB	3626903	c.-290T>A	upstream_gene_variant	0.5	bedaquiline
mtrA	3626912	c.438T>C	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
mtrA	3626912	c.438T>C	synonymous_variant	0.52	bedaquiline
mtrB	3626930	c.-317A>G	upstream_gene_variant	0.47	rifampicin
mtrB	3626930	c.-317A>G	upstream_gene_variant	0.47	bedaquiline
mtrA	3626939	p.Glu137Asp	missense_variant	0.41	rifampicin
mtrA	3626939	p.Glu137Asp	missense_variant	0.41	bedaquiline
mtrB	3626942	c.-329A>C	upstream_gene_variant	0.41	rifampicin
mtrB	3626942	c.-329A>C	upstream_gene_variant	0.41	bedaquiline
mtrB	3626954	c.-341C>G	upstream_gene_variant	0.43	rifampicin
mtrB	3626954	c.-341C>G	upstream_gene_variant	0.43	bedaquiline
mtrB	3626969	c.-356C>G	upstream_gene_variant	0.45	rifampicin
mtrB	3626969	c.-356C>G	upstream_gene_variant	0.45	bedaquiline
mtrB	3626972	c.-359A>G	upstream_gene_variant	0.46	rifampicin
mtrB	3626972	c.-359A>G	upstream_gene_variant	0.46	bedaquiline
mtrB	3627008	c.-395G>C	upstream_gene_variant	0.61	rifampicin
mtrB	3627008	c.-395G>C	upstream_gene_variant	0.61	bedaquiline
mtrB	3627011	c.-398T>G	upstream_gene_variant	0.61	rifampicin
mtrB	3627011	c.-398T>G	upstream_gene_variant	0.61	bedaquiline
mtrB	3627059	c.-446G>C	upstream_gene_variant	0.69	rifampicin
mtrB	3627059	c.-446G>C	upstream_gene_variant	0.69	bedaquiline
mtrA	3627068	c.282T>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
mtrA	3627068	c.282T>C	synonymous_variant	0.68	bedaquiline
mtrB	3627071	c.-458G>C	upstream_gene_variant	0.65	rifampicin
mtrB	3627071	c.-458G>C	upstream_gene_variant	0.65	bedaquiline
mtrA	3627080	c.270T>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
mtrA	3627080	c.270T>C	synonymous_variant	0.61	bedaquiline
mtrA	3627098	c.252A>C	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
mtrA	3627098	c.252A>C	synonymous_variant	0.54	bedaquiline
mtrB	3627104	c.-491C>G	upstream_gene_variant	0.52	rifampicin
mtrB	3627104	c.-491C>G	upstream_gene_variant	0.52	bedaquiline
mtrB	3627110	c.-497G>C	upstream_gene_variant	0.5	rifampicin
mtrB	3627110	c.-497G>C	upstream_gene_variant	0.5	bedaquiline
mtrA	3627227	c.123T>C	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
mtrA	3627227	c.123T>C	synonymous_variant	0.48	bedaquiline
mtrB	3627236	c.-623T>C	upstream_gene_variant	0.46	rifampicin
mtrB	3627236	c.-623T>C	upstream_gene_variant	0.46	bedaquiline
mtrA	3627239	c.111C>T	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
mtrA	3627239	c.111C>T	synonymous_variant	0.46	bedaquiline	Not assoc w R - Interim
mtrB	3627263	c.-650C>T	upstream_gene_variant	0.5	rifampicin
mtrB	3627263	c.-650C>T	upstream_gene_variant	0.5	bedaquiline
mtrB	3627266	c.-653A>G	upstream_gene_variant	0.5	rifampicin
mtrB	3627266	c.-653A>G	upstream_gene_variant	0.5	bedaquiline
mtrB	3627272	c.-659G>T	upstream_gene_variant	0.51	rifampicin
mtrB	3627272	c.-659G>T	upstream_gene_variant	0.51	bedaquiline
mtrA	3627277	c.73C>T	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
mtrA	3627277	c.73C>T	synonymous_variant	0.53	bedaquiline
mtrB	3627296	c.-683T>C	upstream_gene_variant	0.55	rifampicin
mtrB	3627296	c.-683T>C	upstream_gene_variant	0.55	bedaquiline
mtrB	3627301	c.-688T>C	upstream_gene_variant	0.58	rifampicin
mtrB	3627301	c.-688T>C	upstream_gene_variant	0.58	bedaquiline
mtrB	3627317	c.-704T>C	upstream_gene_variant	0.5	rifampicin
mtrB	3627317	c.-704T>C	upstream_gene_variant	0.5	bedaquiline
mtrB	3627323	c.-712_-710delTTGinsCTC	upstream_gene_variant	0.47	rifampicin
mtrB	3627323	c.-712_-710delTTGinsCTC	upstream_gene_variant	0.47	bedaquiline
mtrA	3627870	c.-521C>G	upstream_gene_variant	0.5	rifampicin
mtrA	3627870	c.-521C>G	upstream_gene_variant	0.5	bedaquiline
mtrA	3627872	c.-523T>C	upstream_gene_variant	0.5	rifampicin
mtrA	3627872	c.-523T>C	upstream_gene_variant	0.5	bedaquiline
mtrA	3627882	c.-534_-533delTCinsGA	upstream_gene_variant	0.47	rifampicin
mtrA	3627882	c.-534_-533delTCinsGA	upstream_gene_variant	0.47	bedaquiline
mtrA	3627884	c.-535A>C	upstream_gene_variant	0.47	rifampicin
mtrA	3627884	c.-535A>C	upstream_gene_variant	0.47	bedaquiline
mtrA	3627901	c.-552G>C	upstream_gene_variant	0.47	rifampicin
mtrA	3627901	c.-552G>C	upstream_gene_variant	0.47	bedaquiline
mtrA	3627902	c.-553C>T	upstream_gene_variant	0.44	rifampicin
mtrA	3627902	c.-553C>T	upstream_gene_variant	0.44	bedaquiline
mtrA	3627911	c.-562G>A	upstream_gene_variant	0.44	rifampicin
mtrA	3627911	c.-562G>A	upstream_gene_variant	0.44	bedaquiline
mtrA	3627917	c.-568G>C	upstream_gene_variant	0.47	rifampicin
mtrA	3627917	c.-568G>C	upstream_gene_variant	0.47	bedaquiline
mtrA	3627920	c.-571A>G	upstream_gene_variant	0.5	rifampicin
mtrA	3627920	c.-571A>G	upstream_gene_variant	0.5	bedaquiline
fbiA	3640291	c.-252T>C	upstream_gene_variant	0.5	pretomanid
					delamanid
					clofazimine
fbiA	3640302	c.-241T>A	upstream_gene_variant	0.45	pretomanid
					delamanid
					clofazimine
fbiA	3640304	c.-239_-238delAAinsG	upstream_gene_variant	0.45	pretomanid
					delamanid
					clofazimine
fbiA	3640347	c.-196A>G	upstream_gene_variant	0.65	pretomanid
					delamanid
					clofazimine
fbiA	3640365	c.-178C>G	upstream_gene_variant	0.54	pretomanid
					delamanid
					clofazimine
fbiB	3641678	c.144T>G	synonymous_variant	0.29	pretomanid
					delamanid
					clofazimine
fbiB	3641699	c.165A>G	synonymous_variant	0.41	pretomanid
					delamanid
					clofazimine
fbiB	3641717	c.183T>G	synonymous_variant	0.35	pretomanid
					delamanid
					clofazimine
fbiB	3641720	c.186G>A	synonymous_variant	0.33	pretomanid
					delamanid
					clofazimine
fbiB	3641723	c.189T>A	synonymous_variant	0.35	pretomanid
					delamanid
					clofazimine
fbiB	3641726	c.192C>T	synonymous_variant	0.35	pretomanid
					delamanid
					clofazimine
fbiB	3641729	c.195A>G	synonymous_variant	0.38	pretomanid
					delamanid
					clofazimine
fbiB	3641733	p.Pro67Asp	missense_variant	0.38	pretomanid
					delamanid
					clofazimine
fbiB	3641739	p.Gln69Glu	missense_variant	0.4	pretomanid
					delamanid
					clofazimine
fbiB	3641742	c.208A>C	synonymous_variant	0.43	pretomanid
					delamanid
					clofazimine
fbiB	3641750	c.216A>G	synonymous_variant	0.38	pretomanid
					delamanid
					clofazimine
rpoA	3877533	c.975C>G	synonymous_variant	0.5	rifampicin
rpoA	3877545	c.963G>C	synonymous_variant	0.61	rifampicin
rpoA	3877557	c.951C>G	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoA	3877569	c.939G>C	synonymous_variant	0.72	rifampicin
rpoA	3877587	c.921A>G	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoA	3877593	c.915C>T	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoA	3877596	c.912G>C	synonymous_variant	0.65	rifampicin
rpoA	3877613	p.Ile299Val	missense_variant	0.7	rifampicin
rpoA	3877656	c.852T>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoA	3877665	c.843C>A	synonymous_variant	0.58	rifampicin
rpoA	3877668	c.840A>G	synonymous_variant	0.58	rifampicin
rpoA	3877677	p.Ala277Ser	missense_variant	0.6	rifampicin
rpoA	3877680	c.828G>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoA	3877686	c.822A>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoA	3877692	c.816G>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoA	3877704	c.804G>C	synonymous_variant	0.79	rifampicin
rpoA	3877737	c.771G>C	synonymous_variant	0.75	rifampicin
rpoA	3877743	c.765T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoA	3877746	c.762G>C	synonymous_variant	0.78	rifampicin
rpoA	3877758	c.750G>C	synonymous_variant	0.77	rifampicin
rpoA	3877764	c.744C>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoA	3877770	c.738A>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoA	3877773	c.735G>C	synonymous_variant	0.8	rifampicin
rpoA	3877776	c.732T>C	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoA	3877782	c.726T>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoA	3877785	c.723C>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoA	3877818	c.690A>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoA	3877839	c.669G>T	synonymous_variant	0.65	rifampicin
rpoA	3877848	c.660C>T	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoA	3877857	c.651G>A	synonymous_variant	0.56	rifampicin
rpoA	3877872	c.636C>T	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoA	3877875	c.633T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoA	3877881	c.627G>C	synonymous_variant	0.55	rifampicin
rpoA	3877893	c.615C>T	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoA	3877900	p.Ser203Thr	missense_variant	0.55	rifampicin
rpoA	3877905	c.603A>G	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoA	3877908	p.Asn200Ser	missense_variant	0.54	rifampicin
rpoA	3877962	c.546G>T	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoA	3877989	c.519A>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoA	3878001	c.507A>G	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoA	3878007	c.501C>T	synonymous_variant	0.59	rifampicin
rpoA	3878022	c.486T>C	synonymous_variant	0.52	rifampicin
rpoA	3878025	c.483C>T	synonymous_variant	0.54	rifampicin
rpoA	3878028	c.480G>C	synonymous_variant	0.54	rifampicin
rpoA	3878031	c.477T>C	synonymous_variant	0.55	rifampicin
rpoA	3878046	c.462T>C	synonymous_variant	0.62	rifampicin
rpoA	3878055	c.453A>G	synonymous_variant	0.61	rifampicin
rpoA	3878067	c.441C>G	synonymous_variant	0.64	rifampicin
rpoA	3878070	c.438T>C	synonymous_variant	0.63	rifampicin
rpoA	3878082	c.426T>C	synonymous_variant	0.64	rifampicin
rpoA	3878103	c.405A>G	synonymous_variant	0.73	rifampicin
rpoA	3878106	c.402G>C	synonymous_variant	0.69	rifampicin
rpoA	3878118	c.390T>C	synonymous_variant	0.76	rifampicin
rpoA	3878127	c.381G>C	synonymous_variant	0.73	rifampicin
rpoA	3878130	c.378C>G	synonymous_variant	0.74	rifampicin
rpoA	3878141	c.365_366delGC	frameshift_variant	0.6	rifampicin
rpoA	3878145	c.362_363insGT	frameshift_variant	0.58	rifampicin
rpoA	3878163	c.345C>T	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoA	3878187	c.321C>G	synonymous_variant	0.63	rifampicin
rpoA	3878193	c.315T>C	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
rpoA	3878217	c.291A>G	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoA	3878247	c.261G>C	synonymous_variant	0.68	rifampicin
rpoA	3878253	c.255G>C	synonymous_variant	0.64	rifampicin
rpoA	3878271	c.237T>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoA	3878283	p.Glu75Asp	missense_variant	0.66	rifampicin	Uncertain significance
rpoA	3878295	c.213A>G	synonymous_variant	0.63	rifampicin
rpoA	3878298	c.210A>G	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
rpoA	3878313	c.195G>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoA	3878322	c.186A>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoA	3878331	c.177A>C	synonymous_variant	0.67	rifampicin
rpoA	3878334	c.174T>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoA	3878337	c.171T>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoA	3878364	c.144A>C	synonymous_variant	0.67	rifampicin
rpoA	3878370	c.138T>C	synonymous_variant	0.64	rifampicin
rpoA	3878385	c.123C>G	synonymous_variant	0.6	rifampicin
rpoA	3878406	c.102G>C	synonymous_variant	0.59	rifampicin
rpoA	3878415	c.93C>T	synonymous_variant	0.57	rifampicin
rpoA	3878442	c.66G>C	synonymous_variant	0.53	rifampicin
rpoA	3878454	c.54A>G	synonymous_variant	0.53	rifampicin
rpoA	3878458	p.Asn17Ser	missense_variant	0.52	rifampicin
rpoA	3878460	c.48C>T	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoA	3878471	p.Val13Ile	missense_variant	0.54	rifampicin
rpoA	3878490	c.18C>G	synonymous_variant	0.52	rifampicin
rpoA	3878496	c.12A>T	synonymous_variant	0.5	rifampicin
rpoA	3878665	c.-158A>G	upstream_gene_variant	0.44	rifampicin	Uncertain significance
rpoA	3878672	c.-165A>T	upstream_gene_variant	0.4	rifampicin
rpoA	3878698	c.-191A>G	upstream_gene_variant	0.5	rifampicin
rpoA	3878701	c.-194C>G	upstream_gene_variant	0.52	rifampicin
rpoA	3878713	c.-208_-206delGCGinsACT	upstream_gene_variant	0.59	rifampicin
rpoA	3878725	c.-218A>G	upstream_gene_variant	0.65	rifampicin
rpoA	3878742	c.-235G>A	upstream_gene_variant	0.65	rifampicin
rpoA	3878746	c.-239A>G	upstream_gene_variant	0.62	rifampicin	Uncertain significance
rpoA	3878764	c.-257A>G	upstream_gene_variant	0.56	rifampicin
rpoA	3878767	c.-260G>T	upstream_gene_variant	0.56	rifampicin
rpoA	3878785	c.-278T>C	upstream_gene_variant	0.57	rifampicin
rpoA	3878788	c.-281G>C	upstream_gene_variant	0.58	rifampicin	Uncertain significance
rpoA	3878797	c.-290G>C	upstream_gene_variant	0.6	rifampicin
rpoA	3878806	c.-299C>A	upstream_gene_variant	0.66	rifampicin
rpoA	3878809	c.-302T>C	upstream_gene_variant	0.64	rifampicin
rpoA	3878833	c.-326C>G	upstream_gene_variant	0.58	rifampicin
rpoA	3878853	c.-346G>A	upstream_gene_variant	0.61	rifampicin
rpoA	3878872	c.-365G>C	upstream_gene_variant	0.57	rifampicin
rpoA	3878878	c.-371T>C	upstream_gene_variant	0.58	rifampicin	Uncertain significance
rpoA	3878884	c.-377C>G	upstream_gene_variant	0.54	rifampicin
rpoA	3878908	c.-403_-401delAACinsTCG	upstream_gene_variant	0.42	rifampicin
rpoA	3878914	c.-407T>C	upstream_gene_variant	0.42	rifampicin	Uncertain significance
rpoA	3878917	c.-410G>C	upstream_gene_variant	0.44	rifampicin
rpoA	3878938	c.-431T>C	upstream_gene_variant	0.44	rifampicin
rpoA	3878947	c.-440G>C	upstream_gene_variant	0.49	rifampicin	Uncertain significance
rpoA	3878953	c.-446C>T	upstream_gene_variant	0.47	rifampicin
rpoA	3878961	c.-454C>T	upstream_gene_variant	0.47	rifampicin	Uncertain significance
rpoA	3878968	c.-461T>C	upstream_gene_variant	0.42	rifampicin	Uncertain significance
rpoA	3878974	c.-469_-467delATCinsGTG	upstream_gene_variant	0.43	rifampicin
rpoA	3878995	c.-488A>G	upstream_gene_variant	0.46	rifampicin
rpoA	3878998	c.-491C>G	upstream_gene_variant	0.43	rifampicin	Uncertain significance
rpoA	3879004	c.-499_-497delAAGinsCGC	upstream_gene_variant	0.42	rifampicin
rpoA	3879016	c.-509A>G	upstream_gene_variant	0.64	rifampicin
rpoA	3879022	c.-515G>C	upstream_gene_variant	0.64	rifampicin
rpoA	3879031	c.-526_-524delCCCinsTCG	upstream_gene_variant	0.57	rifampicin
rpoA	3879034	c.-527G>C	upstream_gene_variant	0.55	rifampicin
rpoA	3879037	c.-530G>C	upstream_gene_variant	0.52	rifampicin
rpoA	3879088	c.-581A>C	upstream_gene_variant	0.38	rifampicin
rpoA	3879094	c.-587T>C	upstream_gene_variant	0.36	rifampicin
rpoA	3879097	c.-590C>G	upstream_gene_variant	0.38	rifampicin
rpoA	3879121	c.-617_-614delGCTTinsCCAG	upstream_gene_variant	0.3	rifampicin
rpoA	3879125	c.-618T>G	upstream_gene_variant	0.24	rifampicin
rpoA	3879126	c.-620T>C	upstream_gene_variant	0.27	rifampicin
rpoA	3879142	c.-637_-635delATCinsGTG	upstream_gene_variant	0.42	rifampicin
rpoA	3879148	c.-641G>C	upstream_gene_variant	0.5	rifampicin
rpoA	3879154	c.-647T>C	upstream_gene_variant	0.53	rifampicin
rpoA	3879160	c.-653A>G	upstream_gene_variant	0.55	rifampicin
rpoA	3879178	c.-671T>G	upstream_gene_variant	0.6	rifampicin
rpoA	3879188	c.-681T>A	upstream_gene_variant	0.55	rifampicin
rpoA	3879192	c.-685G>T	upstream_gene_variant	0.57	rifampicin
rpoA	3879219	c.-712C>G	upstream_gene_variant	0.56	rifampicin
rpoA	3879222	c.-715T>C	upstream_gene_variant	0.6	rifampicin
rpoA	3879226	c.-719G>C	upstream_gene_variant	0.65	rifampicin
rpoA	3879232	c.-725A>G	upstream_gene_variant	0.64	rifampicin
rpoA	3879238	c.-731C>T	upstream_gene_variant	0.62	rifampicin
ddn	3986616	c.-228_-227delAGinsGC	upstream_gene_variant	0.39	pretomanid
ddn	3986616	c.-228_-227delAGinsGC	upstream_gene_variant	0.39	delamanid
ddn	3986636	c.-208C>G	upstream_gene_variant	0.47	pretomanid
ddn	3986636	c.-208C>G	upstream_gene_variant	0.47	delamanid
ddn	3986639	c.-205G>C	upstream_gene_variant	0.44	pretomanid
ddn	3986639	c.-205G>C	upstream_gene_variant	0.44	delamanid
ddn	3986648	c.-196C>G	upstream_gene_variant	0.42	pretomanid
ddn	3986648	c.-196C>G	upstream_gene_variant	0.42	delamanid
ddn	3986657	c.-187C>G	upstream_gene_variant	0.38	pretomanid
ddn	3986657	c.-187C>G	upstream_gene_variant	0.38	delamanid
ddn	3986667	c.-177_-176delCTinsAC	upstream_gene_variant	0.33	pretomanid
ddn	3986667	c.-177_-176delCTinsAC	upstream_gene_variant	0.33	delamanid
ddn	3986696	c.-148G>T	upstream_gene_variant	0.39	pretomanid
ddn	3986696	c.-148G>T	upstream_gene_variant	0.39	delamanid
ddn	3986705	c.-139C>G	upstream_gene_variant	0.44	pretomanid
ddn	3986705	c.-139C>G	upstream_gene_variant	0.44	delamanid
clpC1	4038236	p.Thr823Ala	missense_variant	0.55	pyrazinamide
clpC1	4038239	c.2466T>A	synonymous_variant	0.5	pyrazinamide
clpC1	4038266	c.2439C>T	synonymous_variant	0.55	pyrazinamide	Not assoc w R - Interim
clpC1	4038270	p.Pro812Ser	missense_variant	0.53	pyrazinamide
clpC1	4038272	c.2433T>C	synonymous_variant	0.55	pyrazinamide
clpC1	4038275	c.2430A>G	synonymous_variant	0.57	pyrazinamide
clpC1	4038278	c.2427T>C	synonymous_variant	0.55	pyrazinamide
clpC1	4038293	c.2412G>C	synonymous_variant	0.58	pyrazinamide
clpC1	4038308	p.Val799Ile	missense_variant	0.52	pyrazinamide
clpC1	4038320	c.2385G>C	synonymous_variant	0.6	pyrazinamide
clpC1	4038326	c.2379G>A	synonymous_variant	0.56	pyrazinamide
clpC1	4038350	c.2355C>G	synonymous_variant	0.6	pyrazinamide
clpC1	4038356	c.2349T>C	synonymous_variant	0.58	pyrazinamide
clpC1	4038359	c.2346A>G	synonymous_variant	0.58	pyrazinamide
clpC1	4038368	c.2337T>G	synonymous_variant	0.59	pyrazinamide
clpC1	4038388	c.2317T>C	synonymous_variant	0.64	pyrazinamide
clpC1	4038392	c.2313C>T	synonymous_variant	0.62	pyrazinamide
clpC1	4038398	c.2307G>T	synonymous_variant	0.65	pyrazinamide
clpC1	4038403	c.2302T>C	synonymous_variant	0.59	pyrazinamide	Not assoc w R - Interim
clpC1	4038419	c.2286T>C	synonymous_variant	0.44	pyrazinamide
clpC1	4038569	c.2136C>T	synonymous_variant	0.55	pyrazinamide
clpC1	4038596	c.2109A>G	synonymous_variant	0.44	pyrazinamide
clpC1	4038623	c.2082A>G	synonymous_variant	0.55	pyrazinamide
clpC1	4038695	c.2010C>A	synonymous_variant	0.32	pyrazinamide
clpC1	4038704	c.2001T>C	synonymous_variant	0.32	pyrazinamide
clpC1	4038842	c.1863G>A	synonymous_variant	0.69	pyrazinamide	Not assoc w R - Interim
clpC1	4038965	c.1740T>C	synonymous_variant	0.37	pyrazinamide
clpC1	4038971	c.1734T>C	synonymous_variant	0.39	pyrazinamide
clpC1	4038974	c.1731T>C	synonymous_variant	0.42	pyrazinamide	Not assoc w R - Interim
clpC1	4038986	c.1719C>T	synonymous_variant	0.61	pyrazinamide
clpC1	4038989	c.1716T>C	synonymous_variant	0.58	pyrazinamide
clpC1	4038997	c.1708T>C	synonymous_variant	0.65	pyrazinamide	Not assoc w R - Interim
clpC1	4039010	c.1695G>C	synonymous_variant	0.68	pyrazinamide
clpC1	4039076	c.1629G>A	synonymous_variant	0.71	pyrazinamide
clpC1	4039097	c.1608G>T	synonymous_variant	0.62	pyrazinamide
clpC1	4039103	c.1602T>C	synonymous_variant	0.57	pyrazinamide
clpC1	4039106	c.1599G>C	synonymous_variant	0.57	pyrazinamide
clpC1	4039112	c.1593C>G	synonymous_variant	0.69	pyrazinamide
clpC1	4039121	c.1584T>C	synonymous_variant	0.73	pyrazinamide
clpC1	4039124	c.1581C>G	synonymous_variant	0.71	pyrazinamide
clpC1	4039140	p.Glu522Val	missense_variant	0.65	pyrazinamide
clpC1	4039142	c.1563A>G	synonymous_variant	0.62	pyrazinamide
clpC1	4039145	c.1560G>C	synonymous_variant	0.66	pyrazinamide
clpC1	4039166	c.1539G>A	synonymous_variant	0.62	pyrazinamide
clpC1	4039169	p.Glu512Asp	missense_variant	0.62	pyrazinamide
clpC1	4039172	c.1533A>G	synonymous_variant	0.6	pyrazinamide
clpC1	4039178	c.1527G>C	synonymous_variant	0.6	pyrazinamide
clpC1	4039183	c.1522T>C	synonymous_variant	0.61	pyrazinamide
clpC1	4039187	c.1518G>T	synonymous_variant	0.64	pyrazinamide
clpC1	4039190	c.1515C>G	synonymous_variant	0.67	pyrazinamide
clpC1	4039226	c.1479T>C	synonymous_variant	0.46	pyrazinamide	Not assoc w R - Interim
clpC1	4039382	c.1323C>T	synonymous_variant	0.27	pyrazinamide	Not assoc w R - Interim
clpC1	4039391	c.1314T>G	synonymous_variant	0.32	pyrazinamide
clpC1	4039409	c.1296T>C	synonymous_variant	0.5	pyrazinamide
clpC1	4039412	c.1293T>A	synonymous_variant	0.5	pyrazinamide
clpC1	4039415	p.Glu430Asp	missense_variant	0.47	pyrazinamide	Uncertain significance
clpC1	4039430	c.1275T>C	synonymous_variant	0.48	pyrazinamide
clpC1	4039439	c.1266C>T	synonymous_variant	0.5	pyrazinamide
clpC1	4039442	c.1263A>G	synonymous_variant	0.54	pyrazinamide
clpC1	4039463	c.1242C>G	synonymous_variant	0.68	pyrazinamide
clpC1	4039466	c.1239T>C	synonymous_variant	0.66	pyrazinamide
clpC1	4039469	c.1236T>C	synonymous_variant	0.65	pyrazinamide
clpC1	4039481	c.1224T>C	synonymous_variant	0.6	pyrazinamide
clpC1	4039484	c.1221T>C	synonymous_variant	0.58	pyrazinamide
clpC1	4039487	c.1218G>C	synonymous_variant	0.58	pyrazinamide
clpC1	4039517	c.1188C>G	synonymous_variant	0.69	pyrazinamide
clpC1	4039552	c.1153C>T	synonymous_variant	0.62	pyrazinamide
clpC1	4039556	c.1149G>A	synonymous_variant	0.6	pyrazinamide
clpC1	4039559	c.1146C>G	synonymous_variant	0.6	pyrazinamide
clpC1	4039570	p.Met379Leu	missense_variant	0.65	pyrazinamide	Uncertain significance
clpC1	4039574	p.Ala377Gly	missense_variant	0.65	pyrazinamide
clpC1	4039586	c.1119G>C	synonymous_variant	0.71	pyrazinamide
clpC1	4039601	c.1104G>C	synonymous_variant	0.73	pyrazinamide
clpC1	4039610	c.1095G>C	synonymous_variant	0.74	pyrazinamide
clpC1	4039616	c.1089G>C	synonymous_variant	0.76	pyrazinamide
clpC1	4039661	c.1044T>C	synonymous_variant	0.8	pyrazinamide
clpC1	4039691	c.1014G>C	synonymous_variant	0.74	pyrazinamide
clpC1	4039724	c.981A>G	synonymous_variant	0.55	pyrazinamide
clpC1	4039831	c.874T>C	synonymous_variant	0.35	pyrazinamide
clpC1	4039832	c.873C>G	synonymous_variant	0.35	pyrazinamide
clpC1	4039850	c.855T>C	synonymous_variant	0.44	pyrazinamide
clpC1	4039865	c.840T>C	synonymous_variant	0.47	pyrazinamide
clpC1	4039931	c.774T>C	synonymous_variant	0.57	pyrazinamide
clpC1	4039937	c.768G>C	synonymous_variant	0.48	pyrazinamide
clpC1	4039952	c.753T>C	synonymous_variant	0.45	pyrazinamide
clpC1	4039958	c.747G>C	synonymous_variant	0.45	pyrazinamide
clpC1	4039985	c.720G>A	synonymous_variant	0.41	pyrazinamide
clpC1	4040009	c.696C>G	synonymous_variant	0.62	pyrazinamide
clpC1	4040015	c.690G>T	synonymous_variant	0.59	pyrazinamide
clpC1	4040018	c.687G>C	synonymous_variant	0.61	pyrazinamide
clpC1	4040030	c.675C>G	synonymous_variant	0.65	pyrazinamide
clpC1	4040033	c.672G>C	synonymous_variant	0.66	pyrazinamide
clpC1	4040090	c.615T>C	synonymous_variant	0.78	pyrazinamide	Not assoc w R - Interim
clpC1	4040093	c.612C>G	synonymous_variant	0.78	pyrazinamide	Not assoc w R - Interim
clpC1	4040108	c.597G>T	synonymous_variant	0.77	pyrazinamide
clpC1	4040126	c.579C>T	synonymous_variant	0.77	pyrazinamide	Not assoc w R - Interim
clpC1	4040144	c.561G>C	synonymous_variant	0.78	pyrazinamide
clpC1	4040147	c.558A>G	synonymous_variant	0.74	pyrazinamide	Not assoc w R - Interim
clpC1	4040159	c.546G>C	synonymous_variant	0.64	pyrazinamide
clpC1	4040162	c.543G>C	synonymous_variant	0.57	pyrazinamide	Not assoc w R - Interim
clpC1	4040168	c.537G>C	synonymous_variant	0.58	pyrazinamide
clpC1	4040246	c.459C>G	synonymous_variant	0.5	pyrazinamide
clpC1	4040267	c.438A>G	synonymous_variant	0.55	pyrazinamide	Not assoc w R - Interim
clpC1	4040480	c.225T>C	synonymous_variant	0.25	pyrazinamide	Not assoc w R - Interim
clpC1	4040486	c.219G>A	synonymous_variant	0.22	pyrazinamide
clpC1	4040495	c.210C>T	synonymous_variant	0.25	pyrazinamide
clpC1	4040517	p.Val63Ala	missense_variant	0.79	pyrazinamide	Not assoc w R - Interim
panD	4044090	c.192C>A	synonymous_variant	0.38	pyrazinamide
panD	4044096	c.186C>T	synonymous_variant	0.38	pyrazinamide
panD	4044119	c.163C>T	synonymous_variant	0.43	pyrazinamide
panD	4044120	c.162A>G	synonymous_variant	0.43	pyrazinamide
panD	4044123	c.159T>C	synonymous_variant	0.41	pyrazinamide
panD	4044126	c.156T>C	synonymous_variant	0.41	pyrazinamide
panD	4044138	c.144T>C	synonymous_variant	0.48	pyrazinamide	Not assoc w R - Interim
panD	4044150	c.132A>C	synonymous_variant	0.5	pyrazinamide
panD	4044162	c.120A>G	synonymous_variant	0.47	pyrazinamide
panD	4044174	c.108C>G	synonymous_variant	0.47	pyrazinamide
glpK	4138382	c.1374A>C	synonymous_variant	0.37	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138385	c.1371A>G	synonymous_variant	0.42	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138394	c.1362G>A	synonymous_variant	0.42	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138404	p.Val451Glu	missense_variant	0.43	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138429	c.1327T>C	synonymous_variant	0.45	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138451	c.1305T>C	synonymous_variant	0.45	levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4138457	c.1299C>T	synonymous_variant	0.46	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4138460	c.1296C>T	synonymous_variant	0.46	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138463	c.1293C>G	synonymous_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138478	c.1278T>C	synonymous_variant	0.63	levofloxacin	Not assoc w R - Interim
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4138481	c.1275G>C	synonymous_variant	0.61	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138490	p.Val422Ile	missense_variant	0.65	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138495	p.Gln421Glu	missense_variant	0.63	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138502	c.1254T>G	synonymous_variant	0.63	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138505	c.1251T>C	synonymous_variant	0.63	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138511	c.1245C>T	synonymous_variant	0.61	levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4138514	c.1242A>C	synonymous_variant	0.62	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138535	c.1221T>C	synonymous_variant	0.53	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138568	c.1188A>C	synonymous_variant	0.59	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138574	c.1182G>C	synonymous_variant	0.52	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138583	c.1173G>T	synonymous_variant	0.53	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138598	c.1158G>C	synonymous_variant	0.51	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138606	c.1150T>C	synonymous_variant	0.62	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138622	c.1134C>T	synonymous_variant	0.67	levofloxacin	Not assoc w R
					moxifloxacin	Not assoc w R
					isoniazid	Not assoc w R
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R
					ethambutol	Not assoc w R
glpK	4138628	c.1128T>C	synonymous_variant	0.69	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138634	c.1122G>A	synonymous_variant	0.74	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4138643	c.1113A>C	synonymous_variant	0.7	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138654	c.1102C>T	synonymous_variant	0.72	levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4138661	c.1095T>C	synonymous_variant	0.68	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138670	c.1086G>C	synonymous_variant	0.7	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138676	c.1080T>C	synonymous_variant	0.67	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138681	p.Met359Val	missense_variant	0.66	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138682	c.1074C>G	synonymous_variant	0.66	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138703	c.1053C>G	synonymous_variant	0.65	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138714	p.Ala348Ser	missense_variant	0.67	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138718	c.1038T>C	synonymous_variant	0.67	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138726	p.Ala344Ser	missense_variant	0.67	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138747	c.1009C>T	synonymous_variant	0.73	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138751	c.1005T>C	synonymous_variant	0.76	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138754	c.1002C>T	synonymous_variant	0.76	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138775	c.981C>T	synonymous_variant	0.73	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138778	c.978C>G	synonymous_variant	0.74	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138793	c.963T>C	synonymous_variant	0.72	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138799	c.957T>G	synonymous_variant	0.77	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138811	c.945C>G	synonymous_variant	0.77	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138817	c.939T>C	synonymous_variant	0.73	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138822	p.Asn312Asp	missense_variant	0.71	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138829	c.927A>G	synonymous_variant	0.78	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4138835	c.921C>T	synonymous_variant	0.75	levofloxacin
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4139177	c.579T>C	synonymous_variant	0.4	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139186	c.558_570delCGGGCCGCGGGGGinsGGGACCGCGTGGC	synonymous_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139267	c.489C>A	synonymous_variant	0.76	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139270	c.486C>G	synonymous_variant	0.75	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139273	c.483A>T	synonymous_variant	0.74	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139276	c.480T>C	synonymous_variant	0.77	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139285	c.471A>G	synonymous_variant	0.74	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139290	c.466C>T	synonymous_variant	0.68	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139336	c.420C>T	synonymous_variant	0.58	levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4139356	p.Leu134Val	missense_variant	0.5	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139378	c.378G>C	synonymous_variant	0.47	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139384	c.372G>C	synonymous_variant	0.53	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139387	c.369G>C	synonymous_variant	0.47	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139396	c.360C>T	synonymous_variant	0.56	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4139402	c.354C>G	synonymous_variant	0.56	levofloxacin
					moxifloxacin
					isoniazid	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4139408	c.348T>C	synonymous_variant	0.53	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139417	c.339A>C	synonymous_variant	0.56	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139420	c.336T>C	synonymous_variant	0.5	levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4139576	c.180G>T	synonymous_variant	0.52	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139588	c.168G>C	synonymous_variant	0.61	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139603	c.153C>G	synonymous_variant	0.65	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139609	c.147C>A	synonymous_variant	0.66	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139615	p.Glu47Asp	missense_variant	0.67	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139627	c.129G>A	synonymous_variant	0.68	levofloxacin	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
					streptomycin
					rifampicin	Not assoc w R - Interim
					ethambutol	Not assoc w R - Interim
glpK	4139630	c.126C>T	synonymous_variant	0.68	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139633	c.123C>T	synonymous_variant	0.68	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139648	c.108T>C	synonymous_variant	0.71	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139652	p.His35Gly	missense_variant	0.72	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
glpK	4139678	c.78C>T	synonymous_variant	0.71	levofloxacin
					moxifloxacin
					isoniazid
					streptomycin
					rifampicin
					ethambutol
embC	4239095	c.-768C>G	upstream_gene_variant	0.35	ethambutol
embC	4239101	c.-762C>T	upstream_gene_variant	0.4	ethambutol
embC	4239110	c.-753C>G	upstream_gene_variant	0.45	ethambutol
embC	4239117	c.-746_-745delCTinsGC	upstream_gene_variant	0.43	ethambutol
embC	4239125	c.-738C>G	upstream_gene_variant	0.52	ethambutol
embC	4239146	c.-717A>C	upstream_gene_variant	0.55	ethambutol
embC	4239147	c.-716T>C	upstream_gene_variant	0.57	ethambutol
embC	4239152	c.-711G>C	upstream_gene_variant	0.57	ethambutol
embC	4239161	c.-702A>G	upstream_gene_variant	0.59	ethambutol
embC	4239188	c.-675G>C	upstream_gene_variant	0.48	ethambutol	Uncertain significance
embC	4239200	c.-663G>C	upstream_gene_variant	0.41	ethambutol
embC	4239209	c.-654G>C	upstream_gene_variant	0.34	ethambutol
embC	4239215	c.-648T>G	upstream_gene_variant	0.3	ethambutol
embC	4239217	c.-646C>T	upstream_gene_variant	0.24	ethambutol
embC	4239336	c.-527_-525delTTGinsCTC	upstream_gene_variant	0.3	ethambutol
embC	4239344	c.-519G>C	upstream_gene_variant	0.3	ethambutol
embC	4239350	c.-513G>C	upstream_gene_variant	0.27	ethambutol
embC	4239353	c.-510C>G	upstream_gene_variant	0.29	ethambutol
embC	4239378	c.-485T>G	upstream_gene_variant	0.3	ethambutol
embC	4239383	c.-480C>G	upstream_gene_variant	0.33	ethambutol
embC	4239392	c.-471C>T	upstream_gene_variant	0.35	ethambutol
embC	4239398	c.-465G>A	upstream_gene_variant	0.35	ethambutol	Uncertain significance
embC	4240480	c.618G>A	synonymous_variant	0.41	ethambutol
embC	4240484	p.Ala208Thr	missense_variant	0.41	ethambutol
embC	4240489	c.627A>G	synonymous_variant	0.36	ethambutol
embC	4240654	c.792C>G	synonymous_variant	0.52	ethambutol	Not assoc w R - Interim
embC	4240655	p.Ala265Ser	missense_variant	0.52	ethambutol
embC	4240671	p.Thr270Ile	missense_variant	1.0	ethambutol	Not assoc w R
embC	4240677	p.Gly272Ala	missense_variant	0.52	ethambutol
embC	4240679	c.817C>T	synonymous_variant	0.5	ethambutol	Not assoc w R - Interim
embC	4240685	p.Thr275Ala	missense_variant	0.61	ethambutol
embC	4240693	c.831T>G	synonymous_variant	0.6	ethambutol
embC	4240702	c.840G>C	synonymous_variant	0.62	ethambutol
embC	4240717	c.855T>C	synonymous_variant	0.64	ethambutol
embC	4240726	c.864G>C	synonymous_variant	0.65	ethambutol	Not assoc w R - Interim
embC	4240735	c.873C>T	synonymous_variant	0.65	ethambutol
embC	4240765	c.903C>G	synonymous_variant	0.71	ethambutol
embC	4240777	c.915G>A	synonymous_variant	0.73	ethambutol	Not assoc w R - Interim
embC	4240780	c.918T>C	synonymous_variant	0.73	ethambutol
embC	4240783	c.921G>C	synonymous_variant	0.72	ethambutol
embC	4240789	c.927T>C	synonymous_variant	0.75	ethambutol
embC	4240795	c.933C>G	synonymous_variant	0.73	ethambutol
embC	4240819	c.957A>G	synonymous_variant	0.76	ethambutol
embC	4240831	c.969T>G	synonymous_variant	0.79	ethambutol
embC	4240852	c.990G>A	synonymous_variant	0.78	ethambutol
embC	4240859	p.Leu333Met	missense_variant	0.76	ethambutol
embC	4240867	c.1005T>G	synonymous_variant	0.73	ethambutol
embC	4240870	c.1008T>C	synonymous_variant	0.72	ethambutol
embC	4240875	p.Ser338Thr	missense_variant	0.7	ethambutol
embC	4240886	p.Ile342Val	missense_variant	0.68	ethambutol
embC	4240987	c.1125G>C	synonymous_variant	0.39	ethambutol
embC	4240990	c.1128A>G	synonymous_variant	0.45	ethambutol
embC	4240996	c.1134G>C	synonymous_variant	0.46	ethambutol
embC	4241008	c.1146G>C	synonymous_variant	0.47	ethambutol
embC	4241011	c.1149C>G	synonymous_variant	0.5	ethambutol
embC	4241017	c.1155T>C	synonymous_variant	0.55	ethambutol
embC	4241023	c.1161T>G	synonymous_variant	0.56	ethambutol
embC	4241039	p.Asp393Asn	missense_variant	0.61	ethambutol
embC	4241042	p.Asn394Asp	missense_variant	0.4	ethambutol	Not assoc w R
embC	4241047	c.1185C>T	synonymous_variant	0.61	ethambutol	Not assoc w R - Interim
embC	4241050	c.1188T>G	synonymous_variant	0.62	ethambutol
embC	4241056	c.1194C>G	synonymous_variant	0.61	ethambutol
embC	4241084	c.1222C>T	synonymous_variant	0.56	ethambutol
embC	4241101	c.1239G>T	synonymous_variant	0.51	ethambutol
embC	4241107	c.1245G>C	synonymous_variant	0.54	ethambutol
embC	4241110	c.1248G>A	synonymous_variant	0.57	ethambutol
embC	4241119	c.1257C>G	synonymous_variant	0.6	ethambutol
embC	4241129	c.1267C>T	synonymous_variant	0.59	ethambutol
embC	4241140	c.1278A>C	synonymous_variant	0.46	ethambutol
embC	4241141	p.Ile427Ala	missense_variant	0.51	ethambutol
embC	4241146	c.1284C>G	synonymous_variant	0.53	ethambutol
embC	4241161	c.1299C>A	synonymous_variant	0.51	ethambutol
embC	4241167	c.1305C>G	synonymous_variant	0.54	ethambutol
embC	4241168	c.1306C>T	synonymous_variant	0.57	ethambutol	Not assoc w R - Interim
embC	4241206	c.1344G>C	synonymous_variant	0.56	ethambutol	Not assoc w R - Interim
embC	4241207	c.1345C>T	synonymous_variant	0.56	ethambutol
embC	4241215	c.1353C>G	synonymous_variant	0.53	ethambutol
embC	4241224	c.1362G>A	synonymous_variant	0.5	ethambutol
embC	4241228	c.1366_1368delCTAinsTTG	synonymous_variant	0.53	ethambutol
embC	4241245	c.1383C>T	synonymous_variant	0.4	ethambutol
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4242838	c.-395C>G	upstream_gene_variant	0.44	ethambutol
embA	4242844	c.-389A>G	upstream_gene_variant	0.46	ethambutol
embC	4242847	c.2985C>G	synonymous_variant	0.48	ethambutol	Not assoc w R - Interim
embC	4242883	c.3021C>G	synonymous_variant	0.53	ethambutol	Not assoc w R - Interim
embA	4242916	c.-317C>G	upstream_gene_variant	0.35	ethambutol
embA	4242919	c.-314A>G	upstream_gene_variant	0.3	ethambutol
embA	4243848	p.Val206Met	missense_variant	1.0	ethambutol	Not assoc w R
embA	4244096	c.864C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4244666	c.1434G>C	synonymous_variant	0.44	ethambutol
embA	4244668	p.Val479Ala	missense_variant	0.44	ethambutol
embA	4244675	c.1443A>G	synonymous_variant	0.47	ethambutol
embA	4244681	c.1449A>G	synonymous_variant	0.5	ethambutol	Not assoc w R - Interim
embA	4244684	c.1452C>G	synonymous_variant	0.5	ethambutol
embA	4244695	p.Lys488Thr	missense_variant	0.52	ethambutol
embA	4244702	c.1470C>G	synonymous_variant	0.5	ethambutol
embA	4244708	c.1476C>G	synonymous_variant	0.54	ethambutol
embA	4244726	c.1494C>T	synonymous_variant	0.5	ethambutol
embA	4244747	c.1515T>C	synonymous_variant	0.59	ethambutol	Not assoc w R - Interim
embA	4244750	c.1518C>G	synonymous_variant	0.61	ethambutol
embA	4244764	p.Val511Ala	missense_variant	0.43	ethambutol
embA	4244768	p.Glu512Asp	missense_variant	0.41	ethambutol
embA	4244771	c.1539G>C	synonymous_variant	0.39	ethambutol
embA	4244778	p.Ser516Ala	missense_variant	0.4	ethambutol
embA	4244802	c.1570T>C	synonymous_variant	0.33	ethambutol
embA	4244805	c.1573C>T	synonymous_variant	0.32	ethambutol
embA	4244808	p.Phe526Leu	missense_variant	0.31	ethambutol
embA	4244814	p.Leu528Met	missense_variant	0.33	ethambutol
embA	4245060	c.1828T>C	synonymous_variant	0.6	ethambutol
embA	4245077	c.1845G>C	synonymous_variant	0.59	ethambutol
embA	4245083	c.1851A>G	synonymous_variant	0.57	ethambutol	Not assoc w R - Interim
embA	4245101	c.1869G>C	synonymous_variant	0.61	ethambutol
embA	4245128	c.1896G>C	synonymous_variant	0.65	ethambutol
embA	4245131	c.1899G>C	synonymous_variant	0.67	ethambutol	Not assoc w R - Interim
embA	4245137	c.1905T>C	synonymous_variant	0.69	ethambutol
embA	4245153	p.Ile641Val	missense_variant	0.69	ethambutol
embA	4245167	c.1935G>C	synonymous_variant	0.68	ethambutol
embA	4245182	c.1950T>C	synonymous_variant	0.76	ethambutol
embA	4245206	c.1974A>C	synonymous_variant	0.63	ethambutol
embA	4245207	c.1975T>C	synonymous_variant	0.63	ethambutol
embA	4245212	c.1980G>C	synonymous_variant	0.63	ethambutol
embA	4245214	p.Ala661Gly	missense_variant	0.63	ethambutol
embA	4245224	c.1992T>C	synonymous_variant	0.68	ethambutol
embA	4245248	c.2016G>A	synonymous_variant	0.52	ethambutol	Not assoc w R - Interim
embA	4245257	c.2025A>G	synonymous_variant	0.48	ethambutol
embA	4245263	c.2031A>G	synonymous_variant	0.38	ethambutol	Not assoc w R - Interim
embA	4245264	p.Asp678Asn	missense_variant	0.37	ethambutol	Uncertain significance
embA	4245281	c.2049C>G	synonymous_variant	0.27	ethambutol
embA	4245282	p.Ile684Val	missense_variant	0.27	ethambutol
embA	4245285	c.2053T>C	synonymous_variant	0.26	ethambutol
embA	4245293	c.2061T>G	synonymous_variant	0.26	ethambutol
embA	4245296	c.2064G>T	synonymous_variant	0.29	ethambutol
embA	4245299	c.2067A>G	synonymous_variant	0.32	ethambutol
embA	4245311	c.2079C>G	synonymous_variant	0.38	ethambutol	Not assoc w R - Interim
embB	4245807	c.-707_-705delTTAinsCTG	upstream_gene_variant	0.27	ethambutol
embA	4245819	p.Ser863Arg	missense_variant	0.28	ethambutol
embA	4245822	p.Pro864Ala	missense_variant	0.31	ethambutol
embB	4245830	c.-684G>C	upstream_gene_variant	0.37	ethambutol
embB	4245845	c.-669T>C	upstream_gene_variant	0.39	ethambutol
embB	4245848	c.-666C>G	upstream_gene_variant	0.39	ethambutol
embB	4245851	c.-663G>C	upstream_gene_variant	0.39	ethambutol
embB	4245875	c.-639G>A	upstream_gene_variant	0.4	ethambutol
embB	4245887	c.-627T>C	upstream_gene_variant	0.36	ethambutol
embA	4245893	p.Ile887Met	missense_variant	0.36	ethambutol
embA	4245969	p.Pro913Ser	missense_variant	1.0	ethambutol	Not assoc w R
embB	4247407	c.894G>C	synonymous_variant	0.41	ethambutol
embB	4247434	c.921C>G	synonymous_variant	0.58	ethambutol
embB	4247437	c.924A>C	synonymous_variant	0.59	ethambutol
embB	4247464	c.951C>G	synonymous_variant	0.76	ethambutol
embB	4247470	c.957T>C	synonymous_variant	0.75	ethambutol
embB	4247497	c.984T>C	synonymous_variant	0.7	ethambutol
embB	4247500	c.987C>G	synonymous_variant	0.74	ethambutol
embB	4247512	c.999T>C	synonymous_variant	0.73	ethambutol
embB	4247527	c.1014G>A	synonymous_variant	0.68	ethambutol
embB	4247530	c.1017G>C	synonymous_variant	0.63	ethambutol
embB	4247539	c.1026T>C	synonymous_variant	0.6	ethambutol
embB	4247646	p.Glu378Ala	missense_variant	1.0	ethambutol	Not assoc w R
embB	4247677	c.1164C>G	synonymous_variant	0.65	ethambutol	Not assoc w R - Interim
embB	4247683	c.1170C>G	synonymous_variant	0.65	ethambutol
embB	4247684	c.1171T>C	synonymous_variant	0.65	ethambutol
embB	4247689	c.1176G>C	synonymous_variant	0.65	ethambutol
embB	4247693	p.Ala394Ser	missense_variant	0.65	ethambutol
embB	4247716	c.1203C>G	synonymous_variant	0.62	ethambutol
embB	4247722	c.1209G>C	synonymous_variant	0.65	ethambutol
embB	4247725	c.1212G>C	synonymous_variant	0.64	ethambutol
embB	4247728	c.1215G>A	synonymous_variant	0.64	ethambutol
embB	4247945	c.1432T>C	synonymous_variant	0.5	ethambutol
embB	4247948	p.Val479Leu	missense_variant	0.5	ethambutol	Uncertain significance
embB	4247977	c.1464C>G	synonymous_variant	0.4	ethambutol
embB	4247986	c.1473C>G	synonymous_variant	0.4	ethambutol
embB	4247998	c.1485C>T	synonymous_variant	0.5	ethambutol
embB	4248001	c.1488C>T	synonymous_variant	0.5	ethambutol	Not assoc w R - Interim
embB	4248008	c.1495C>T	synonymous_variant	0.47	ethambutol
embB	4248013	c.1500A>G	synonymous_variant	0.5	ethambutol
embB	4248020	c.1507T>C	synonymous_variant	0.44	ethambutol
embB	4248139	c.1626C>G	synonymous_variant	0.52	ethambutol
embB	4248142	c.1629T>C	synonymous_variant	0.54	ethambutol
embB	4248149	p.Thr546Ala	missense_variant	0.56	ethambutol	Uncertain significance
embB	4248157	c.1644A>G	synonymous_variant	0.63	ethambutol	Not assoc w R - Interim
embB	4248185	c.1672T>C	synonymous_variant	0.75	ethambutol
embB	4248190	c.1677G>C	synonymous_variant	0.74	ethambutol	Not assoc w R - Interim
embB	4248199	c.1686A>G	synonymous_variant	0.7	ethambutol
embB	4248200	p.Ile563Val	missense_variant	0.7	ethambutol
embB	4248206	p.Ser565Gly	missense_variant	0.7	ethambutol	Uncertain significance
embB	4248214	c.1701C>G	synonymous_variant	0.75	ethambutol
embB	4248220	c.1707A>T	synonymous_variant	0.8	ethambutol
embB	4248223	c.1710G>T	synonymous_variant	0.81	ethambutol	Not assoc w R - Interim
embB	4248275	p.Thr588Ala	missense_variant	0.81	ethambutol
embB	4248280	c.1767C>G	synonymous_variant	0.81	ethambutol
embB	4248283	c.1770C>G	synonymous_variant	0.79	ethambutol
embB	4248305	c.1792C>T	synonymous_variant	0.81	ethambutol
embB	4248316	c.1803C>G	synonymous_variant	0.75	ethambutol
embB	4248319	c.1806A>G	synonymous_variant	0.75	ethambutol
embB	4248322	c.1809G>T	synonymous_variant	0.74	ethambutol
embB	4248334	c.1821C>G	synonymous_variant	0.71	ethambutol
embB	4248338	c.1825C>T	synonymous_variant	0.68	ethambutol
embB	4248350	c.1837T>C	synonymous_variant	0.55	ethambutol
embB	4248355	c.1842A>G	synonymous_variant	0.5	ethambutol
embB	4248358	c.1845C>G	synonymous_variant	0.48	ethambutol
embB	4248361	c.1848A>G	synonymous_variant	0.46	ethambutol	Not assoc w R - Interim
embB	4248362	p.Ser617Ala	missense_variant	0.46	ethambutol
embB	4248368	c.1855C>T	synonymous_variant	0.46	ethambutol
embB	4249237	c.2724A>C	synonymous_variant	0.27	ethambutol
embB	4249246	c.2733A>G	synonymous_variant	0.37	ethambutol
embB	4249249	c.2736C>G	synonymous_variant	0.41	ethambutol
embB	4249255	c.2742G>C	synonymous_variant	0.47	ethambutol
embB	4249264	c.2751G>T	synonymous_variant	0.57	ethambutol
embB	4249276	c.2763A>C	synonymous_variant	0.62	ethambutol
embB	4249282	c.2769A>C	synonymous_variant	0.64	ethambutol
embB	4249321	c.2808A>G	synonymous_variant	0.75	ethambutol
embB	4249323	p.Ala937Asp	missense_variant	0.75	ethambutol
embB	4249339	c.2826T>C	synonymous_variant	0.68	ethambutol
embB	4249369	c.2856T>C	synonymous_variant	0.45	ethambutol
embB	4249376	c.2863C>T	synonymous_variant	0.37	ethambutol
embB	4249381	c.2868A>G	synonymous_variant	0.36	ethambutol
embB	4249390	c.2877C>T	synonymous_variant	0.38	ethambutol
embB	4249405	c.2892C>G	synonymous_variant	0.39	ethambutol
embB	4249417	c.2904A>G	synonymous_variant	0.37	ethambutol
embB	4249420	c.2907G>C	synonymous_variant	0.37	ethambutol
embB	4249423	p.Asp970Glu	missense_variant	0.34	ethambutol	Uncertain significance
embB	4249424	p.Leu971Val	missense_variant	1.0	ethambutol	Uncertain significance
embB	4249429	c.2916C>G	synonymous_variant	0.4	ethambutol
embB	4249444	c.2931T>C	synonymous_variant	0.38	ethambutol
embB	4249447	c.2934G>C	synonymous_variant	0.38	ethambutol
embB	4249450	c.2937C>T	synonymous_variant	0.38	ethambutol	Not assoc w R - Interim
embB	4249462	c.2949G>C	synonymous_variant	0.46	ethambutol
embB	4249486	c.2973T>G	synonymous_variant	0.43	ethambutol
embB	4249492	c.2979C>G	synonymous_variant	0.4	ethambutol
embB	4249618	c.3105C>G	synonymous_variant	0.3	ethambutol
embB	4249627	c.3114G>C	synonymous_variant	0.38	ethambutol
embB	4249648	c.3135G>C	synonymous_variant	0.39	ethambutol
embB	4249663	c.3150C>G	synonymous_variant	0.33	ethambutol
aftB	4267253	c.1584T>C	synonymous_variant	0.67	ethambutol
aftB	4267256	c.1581C>T	synonymous_variant	0.63	ethambutol
aftB	4267266	p.Ala524Gly	missense_variant	0.74	ethambutol
aftB	4267268	c.1569T>C	synonymous_variant	0.74	ethambutol
aftB	4267274	c.1563G>C	synonymous_variant	0.78	ethambutol
aftB	4267297	c.1540T>C	synonymous_variant	0.89	ethambutol
aftB	4267298	c.1539A>G	synonymous_variant	0.89	ethambutol
aftB	4267304	p.Val511Ala	missense_variant	0.94	ethambutol
aftB	4267316	c.1521A>G	synonymous_variant	0.88	ethambutol
aftB	4267325	c.1512G>C	synonymous_variant	0.87	ethambutol
aftB	4267330	c.1507C>A	synonymous_variant	0.85	ethambutol
aftB	4267334	c.1503T>C	synonymous_variant	0.82	ethambutol	Not assoc w R - Interim
aftB	4267337	c.1500C>G	synonymous_variant	0.82	ethambutol
aftB	4267340	c.1497G>T	synonymous_variant	0.69	ethambutol
aftB	4268129	c.708T>C	synonymous_variant	0.41	ethambutol
aftB	4268138	c.699A>C	synonymous_variant	0.45	ethambutol	Not assoc w R - Interim
aftB	4268144	c.693T>C	synonymous_variant	0.5	ethambutol
aftB	4268165	c.672C>T	synonymous_variant	0.52	ethambutol
aftB	4268168	c.669C>G	synonymous_variant	0.52	ethambutol
aftB	4268171	c.666G>C	synonymous_variant	0.52	ethambutol
aftB	4268179	c.658T>C	synonymous_variant	0.53	ethambutol	Not assoc w R - Interim
aftB	4268180	p.Phe219Leu	missense_variant	0.53	ethambutol
aftB	4268183	c.654A>G	synonymous_variant	0.53	ethambutol
aftB	4268201	c.636G>C	synonymous_variant	0.42	ethambutol
aftB	4268205	p.Val211Gly	missense_variant	0.39	ethambutol	Uncertain significance
aftB	4268210	c.627C>T	synonymous_variant	0.36	ethambutol
aftB	4268213	c.624T>G	synonymous_variant	0.33	ethambutol
aftB	4268404	p.Leu145Met	missense_variant	0.48	ethambutol
aftB	4268429	c.408C>G	synonymous_variant	0.68	ethambutol
aftB	4268432	c.405C>G	synonymous_variant	0.66	ethambutol
aftB	4268462	c.375T>C	synonymous_variant	0.73	ethambutol
aftB	4268465	c.372A>C	synonymous_variant	0.74	ethambutol
aftB	4268470	c.367C>T	synonymous_variant	0.77	ethambutol
aftB	4268471	c.366G>C	synonymous_variant	0.79	ethambutol
aftB	4268474	c.363G>A	synonymous_variant	0.77	ethambutol
aftB	4268483	c.354T>G	synonymous_variant	0.77	ethambutol
aftB	4268498	c.339T>C	synonymous_variant	0.69	ethambutol
aftB	4268501	c.336C>T	synonymous_variant	0.66	ethambutol	Not assoc w R - Interim
aftB	4268504	c.333G>T	synonymous_variant	0.66	ethambutol
aftB	4268516	c.321A>G	synonymous_variant	0.59	ethambutol	Not assoc w R - Interim
aftB	4268520	p.Tyr106Phe	missense_variant	0.55	ethambutol
aftB	4268531	c.306C>G	synonymous_variant	0.42	ethambutol
aftB	4268988	c.-152G>T	upstream_gene_variant	0.47	ethambutol
aftB	4269006	c.-170T>C	upstream_gene_variant	0.66	ethambutol
aftB	4269009	c.-173A>G	upstream_gene_variant	0.66	ethambutol
aftB	4269012	c.-176G>C	upstream_gene_variant	0.68	ethambutol
ubiA	4269015	c.819G>A	synonymous_variant	0.68	ethambutol	Not assoc w R - Interim
aftB	4269027	c.-191C>G	upstream_gene_variant	0.73	ethambutol
ubiA	4269030	c.804C>T	synonymous_variant	0.73	ethambutol	Not assoc w R - Interim
aftB	4269033	c.-197T>C	upstream_gene_variant	0.73	ethambutol
aftB	4269048	c.-212C>T	upstream_gene_variant	0.67	ethambutol
ubiA	4269387	p.Glu149Asp	missense_variant	1.0	ethambutol	Not assoc w R
aftB	4269528	c.-692G>C	upstream_gene_variant	0.38	ethambutol
ubiA	4269538	p.Glu99Pro	missense_variant	0.43	ethambutol
aftB	4269549	c.-713C>T	upstream_gene_variant	0.43	ethambutol
aftB	4269561	c.-725G>C	upstream_gene_variant	0.44	ethambutol
aftB	4269573	c.-737A>G	upstream_gene_variant	0.56	ethambutol
aftB	4269594	c.-758A>C	upstream_gene_variant	0.52	ethambutol
aftB	4269597	c.-761G>A	upstream_gene_variant	0.54	ethambutol
ubiA	4269606	c.228T>C	synonymous_variant	0.54	ethambutol	Not assoc w R
aftB	4269606	c.-770T>A	upstream_gene_variant	0.46	ethambutol
aftB	4269612	c.-776T>C	upstream_gene_variant	0.44	ethambutol
ubiA	4269620	p.Val72Ile	missense_variant	0.36	ethambutol
aftB	4269621	c.-785C>G	upstream_gene_variant	0.3	ethambutol
ubiA	4269624	c.210C>T	synonymous_variant	0.3	ethambutol	Not assoc w R - Interim
ubiA	4269627	p.Val69Ile	missense_variant	0.3	ethambutol
aftB	4269639	c.-803C>G	upstream_gene_variant	0.3	ethambutol
whiB6	4338242	p.Gln94Glu	missense_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
whiB6	4338603	c.-82C>T	upstream_gene_variant	1.0	kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
whiB6	4338732	c.-211C>T	upstream_gene_variant	1.0	kanamycin
					capreomycin
					amikacin
gid	4407873	c.330G>T	synonymous_variant	1.0	streptomycin	Not assoc w R

TB-Profiler result