TB-Profiler result

Run: ERR067699

Summary

Run ID: ERR067699

Sample name:

Date: 2024-04-14T09:21:49.315665

Number of reads: 276324

Percentage reads mapped: 10.01

Median coverage: 2.0

Strain: La1;lineage2;lineage4.9

Spoligotype:

Drug-resistance: HR-TB


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.12
lineage4 Euro-American None 0.98
lineage4.9 Euro-American (H37Rv-like) None 0.87
La1 M.bovis None 0.05
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.451_453delGTCinsCG Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1018_1020delGGCinsCT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303948 c.1018_1020delGGCinsCT frameshift_variant&missense_variant 0.71 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.77 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155659 c.451_453delGTCinsCG frameshift_variant&missense_variant 0.64 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 582 c.582A>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
dnaA 585 c.585A>G synonymous_variant 1.0 isoniazid
dnaA 588 c.588A>G synonymous_variant 1.0 isoniazid
dnaA 597 c.597C>G synonymous_variant 1.0 isoniazid Not assoc w R - Interim
dnaA 600 c.600T>C synonymous_variant 1.0 isoniazid
dnaA 609 c.609C>G synonymous_variant 1.0 isoniazid
dnaA 610 c.610C>T synonymous_variant 1.0 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.93 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.93 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.96 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.96 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.96 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.97 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.97 isoniazid Not assoc w R - Interim
dnaA 933 c.933C>G synonymous_variant 0.98 isoniazid
dnaA 954 c.954G>A synonymous_variant 1.0 isoniazid
dnaA 955 c.955_957delAGAinsCT frameshift_variant&missense_variant 1.0 isoniazid Uncertain significance
dnaA 966 c.966T>C synonymous_variant 1.0 isoniazid
dnaA 975 c.975G>T synonymous_variant 1.0 isoniazid
dnaA 984 c.984T>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>T synonymous_variant 1.0 isoniazid
dnaA 996 c.996A>G synonymous_variant 1.0 isoniazid
dnaA 1005 c.1005G>C synonymous_variant 1.0 isoniazid
dnaA 1011 c.1011C>G synonymous_variant 1.0 isoniazid
gyrB 6148 c.909C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6160 c.921C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrB 6193 c.954G>A synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrB 6196 c.957C>T synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrB 6203 c.964_966delAGCinsTCG synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrB 6215 c.976_978delTCGinsAC frameshift_variant&missense_variant 0.92 levofloxacin Uncertain significance
moxifloxacin
gyrB 6262 c.1023G>A synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6304 c.-998C>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6325 c.-977C>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 1.0 levofloxacin
moxifloxacin
gyrB 6329 p.Glu364Gln missense_variant 0.95 levofloxacin
moxifloxacin
gyrB 6362 c.1123_1125delTTGinsCC frameshift_variant&missense_variant 0.94 levofloxacin Uncertain significance
moxifloxacin
gyrA 6367 c.-935C>G upstream_gene_variant 0.94 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.94 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.94 levofloxacin
moxifloxacin
gyrB 6391 c.1152G>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6398 p.Val387Ile missense_variant 0.94 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.93 levofloxacin
moxifloxacin
gyrA 6409 c.-893A>G upstream_gene_variant 0.92 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.83 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.83 levofloxacin Uncertain significance
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.86 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.9 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6784 c.-518C>T upstream_gene_variant 0.9 levofloxacin
moxifloxacin
gyrA 6787 c.-515G>A upstream_gene_variant 0.95 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.95 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6794 p.Ile519Leu missense_variant 0.95 levofloxacin
moxifloxacin
gyrB 6797 p.Gly520Ser missense_variant 0.95 levofloxacin
moxifloxacin
gyrA 6808 c.-494C>A upstream_gene_variant 0.95 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.95 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7349 c.48A>G synonymous_variant 0.8 levofloxacin
moxifloxacin
gyrA 7355 c.54T>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7367 p.Gln22His missense_variant 0.88 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7370 c.69G>A synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 7391 c.90C>T synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 7415 c.114C>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 7418 c.117C>T synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7472 c.171T>C synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.97 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.97 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.98 levofloxacin
moxifloxacin
gyrA 7502 c.201C>T synonymous_variant 0.98 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.98 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.98 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.98 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.98 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7592 c.291G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7631 c.330G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7637 c.336C>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 7658 c.357A>C synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7661 c.360C>T synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 7706 c.405C>G synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 7725 c.424C>T synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.96 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7778 c.477G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.98 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.98 levofloxacin
moxifloxacin
gyrA 7847 c.546G>C synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.97 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 7874 c.573G>C synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 7886 c.585T>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 7889 c.588G>A synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.9 levofloxacin
moxifloxacin
gyrA 8141 c.840C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8156 c.855T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.93 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8267 c.966G>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.95 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8318 c.1017C>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8319 c.1018_1019delAGinsTC synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8354 c.1053G>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8360 c.1059G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>T synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8378 c.1077C>T synonymous_variant 0.96 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.96 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.95 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.94 levofloxacin
moxifloxacin
gyrA 8417 c.1116C>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>C synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 8429 c.1128C>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8456 c.1155C>T synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8813 c.1512C>T synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8825 c.1524G>A synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8849 c.1548C>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8858 c.1557T>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 1.0 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8921 c.1620C>T synonymous_variant 0.95 levofloxacin
moxifloxacin
fgd1 491547 c.765A>C synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fgd1 491569 p.Asp263Asn missense_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491580 p.Ile266Met missense_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491592 c.810G>A synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fgd1 491603 p.Ala274Glu missense_variant 0.95 clofazimine
pretomanid
delamanid
fgd1 491607 c.825G>T synonymous_variant 0.96 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>C synonymous_variant 0.96 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.96 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.93 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>C synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.88 clofazimine
pretomanid
delamanid
mshA 575737 c.390T>C synonymous_variant 0.82 ethionamide
isoniazid
mshA 575744 p.Ala133Thr missense_variant 0.93 ethionamide
isoniazid Uncertain significance
mshA 575749 c.402C>G synonymous_variant 0.94 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.94 ethionamide
isoniazid
mshA 575771 p.Val142Thr missense_variant 0.9 ethionamide
isoniazid
mshA 575776 c.429C>T synonymous_variant 0.9 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.9 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.9 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.9 ethionamide
isoniazid
mshA 575795 p.Ile150Val missense_variant 0.92 ethionamide
isoniazid
mshA 575800 c.453G>T synonymous_variant 0.92 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.93 ethionamide
isoniazid
mshA 575842 c.495G>C synonymous_variant 0.95 ethionamide
isoniazid
mshA 575845 c.498C>G synonymous_variant 0.94 ethionamide
isoniazid
mshA 575848 c.501C>T synonymous_variant 0.94 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 1.0 ethionamide
isoniazid
mshA 575875 c.528C>G synonymous_variant 0.92 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.92 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.85 ethionamide
isoniazid
ccsA 620613 c.723C>T synonymous_variant 0.85 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>C synonymous_variant 0.88 capreomycin
amikacin
kanamycin
ccsA 620625 c.735A>C synonymous_variant 1.0 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>C synonymous_variant 0.83 capreomycin
amikacin
kanamycin
ccsA 620634 c.744C>G synonymous_variant 0.88 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.9 capreomycin
amikacin
kanamycin
ccsA 620670 c.780C>T synonymous_variant 0.91 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.94 capreomycin
amikacin
kanamycin
ccsA 620724 c.834C>T synonymous_variant 0.9 capreomycin
amikacin
kanamycin
ccsA 620730 c.840C>T synonymous_variant 0.96 capreomycin
amikacin
kanamycin
ccsA 620736 c.846G>T synonymous_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>G synonymous_variant 0.95 capreomycin
amikacin
kanamycin
ccsA 620760 c.870C>A synonymous_variant 0.9 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620764 c.874_876delGCCinsTG frameshift_variant&missense_variant 0.9 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.88 capreomycin
amikacin
kanamycin
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.82 ethionamide
Rv0565c 657656 c.-186C>T upstream_gene_variant 0.83 ethionamide
Rv0565c 657668 c.-200_-198delACCinsGG upstream_gene_variant 0.85 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.79 ethionamide
Rv0565c 657690 c.-220C>A upstream_gene_variant 0.79 ethionamide
Rv0565c 657722 c.-254_-252delAACinsCG upstream_gene_variant 0.8 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.73 ethionamide
hadA 731753 c.-177A>G upstream_gene_variant 1.0 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 1.0 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 1.0 isoniazid
hadA 731807 c.-123C>T upstream_gene_variant 1.0 isoniazid
hadA 731810 c.-120G>C upstream_gene_variant 1.0 isoniazid
nusG 734421 c.168A>C synonymous_variant 1.0 rifampicin
nusG 734424 c.171G>C synonymous_variant 1.0 rifampicin
nusG 734439 c.186C>G synonymous_variant 1.0 rifampicin
nusG 734442 c.189G>A synonymous_variant 1.0 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.97 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.97 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.97 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.93 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.83 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.79 rifampicin
rpoB 760082 c.276C>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760104 c.298_300delTCGinsAGC synonymous_variant 0.87 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.94 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.96 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.97 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760271 c.465C>G synonymous_variant 1.0 rifampicin
rpoB 760283 c.477G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 1.0 rifampicin
rpoB 760316 c.510C>G synonymous_variant 1.0 rifampicin
rpoB 760331 c.525G>T synonymous_variant 1.0 rifampicin
rpoB 760334 c.528G>A synonymous_variant 1.0 rifampicin
rpoB 760340 c.534G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 1.0 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 1.0 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 1.0 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 1.0 rifampicin Uncertain significance
rpoB 760412 c.606C>T synonymous_variant 1.0 rifampicin
rpoB 760415 c.609C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760514 c.708C>G synonymous_variant 0.91 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 1.0 rifampicin
rpoB 760674 c.868T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 1.0 rifampicin
rpoB 760751 c.945G>C synonymous_variant 1.0 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 1.0 rifampicin
rpoB 760759 p.Val318Ala missense_variant 1.0 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 1.0 rifampicin
rpoB 760769 c.963C>G synonymous_variant 1.0 rifampicin
rpoB 760778 c.972G>C synonymous_variant 1.0 rifampicin
rpoB 760784 c.978G>C synonymous_variant 1.0 rifampicin
rpoB 760793 c.987A>G synonymous_variant 1.0 rifampicin
rpoB 760805 c.999G>C synonymous_variant 1.0 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 1.0 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 1.0 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760829 c.1023C>T synonymous_variant 1.0 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760848 p.Thr348Ser missense_variant 1.0 rifampicin
rpoB 760856 c.1050C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760862 c.1056G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760877 c.1071G>C synonymous_variant 1.0 rifampicin
rpoB 760880 c.1074G>C synonymous_variant 1.0 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 1.0 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 1.0 rifampicin
rpoB 760887 p.Thr361Val missense_variant 1.0 rifampicin Uncertain significance
rpoB 760916 c.1110C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.94 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.94 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.94 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.94 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.94 rifampicin
rpoB 760982 c.1176G>T synonymous_variant 0.95 rifampicin
rpoB 760985 c.1179G>T synonymous_variant 0.9 rifampicin
rpoB 760991 c.1185G>C synonymous_variant 0.93 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 1.0 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 1.0 rifampicin
rpoB 761126 c.1320G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 761217 c.1411_1413delCCGinsTC frameshift_variant&missense_variant 0.9 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.9 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.6 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.98 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.98 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.92 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.88 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.88 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.88 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.91 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.89 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.89 rifampicin
rpoB 761736 p.Ile644Val missense_variant 0.75 rifampicin Uncertain significance
rpoB 761747 c.1941G>C synonymous_variant 0.81 rifampicin
rpoB 761753 c.1947C>G synonymous_variant 0.84 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.86 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.86 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.86 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.86 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.92 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 1.0 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.97 rifampicin
rpoB 762000 c.2194_2195delTCinsAG synonymous_variant 0.97 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.95 rifampicin
rpoB 762038 c.2232C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.95 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.95 rifampicin
rpoB 762134 c.2328C>T synonymous_variant 0.95 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.9 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.91 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 1.0 rifampicin
rpoB 762299 c.2493G>C synonymous_variant 1.0 rifampicin
rpoB 762308 c.2502G>C synonymous_variant 1.0 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 1.0 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762878 p.Ile1024Met missense_variant 1.0 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 1.0 rifampicin Uncertain significance
rpoC 762917 c.-453C>T upstream_gene_variant 1.0 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762989 c.3183G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763109 c.-261C>G upstream_gene_variant 1.0 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 1.0 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 1.0 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 1.0 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 1.0 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 1.0 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 1.0 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 1.0 rifampicin
rpoC 763208 c.-162T>C upstream_gene_variant 1.0 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763220 c.-150G>A upstream_gene_variant 0.93 rifampicin
rpoB 763227 p.Leu1141Met missense_variant 0.93 rifampicin
rpoC 763232 c.-138C>T upstream_gene_variant 0.93 rifampicin
rpoB 763235 p.Glu1143Asp missense_variant 0.93 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 763241 p.Glu1145Asp missense_variant 0.93 rifampicin
rpoC 763259 c.-111G>C upstream_gene_variant 0.91 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.94 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.94 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCT frameshift_variant&missense_variant 0.94 rifampicin
rpoC 763433 c.64_66delCAAinsAC frameshift_variant&missense_variant 0.94 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.95 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.96 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 1.0 rifampicin
rpoC 763621 c.252C>T synonymous_variant 1.0 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.98 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.98 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.97 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.98 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.96 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.98 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763790 p.Glu141Thr missense_variant 0.89 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.85 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.85 rifampicin
rpoC 763819 c.450G>C synonymous_variant 0.81 rifampicin
rpoC 763825 c.456G>A synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.92 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.93 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.93 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.92 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.94 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.95 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.9 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.89 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.85 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.8 rifampicin
rpoC 764029 p.Glu220Asp missense_variant 0.8 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.82 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.83 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.83 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.88 rifampicin
rpoC 764071 c.702G>C synonymous_variant 0.7 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.7 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.7 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.73 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.64 rifampicin
rpoC 764182 p.Asp271Glu missense_variant 0.73 rifampicin Uncertain significance
rpoC 764188 c.819A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Asn missense_variant 0.7 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.7 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.7 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.7 rifampicin Uncertain significance
rpoC 764227 c.858G>T synonymous_variant 0.93 rifampicin
rpoC 764239 c.870T>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764254 c.885G>C synonymous_variant 1.0 rifampicin
rpoC 764257 c.888G>C synonymous_variant 1.0 rifampicin
rpoC 764263 c.894G>C synonymous_variant 1.0 rifampicin
rpoC 764266 c.897T>C synonymous_variant 1.0 rifampicin
rpoC 764272 c.903G>C synonymous_variant 1.0 rifampicin
rpoC 764278 c.909A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 1.0 rifampicin
rpoC 764293 c.924G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 1.0 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.97 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>T synonymous_variant 0.97 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.94 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 1.0 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 1.0 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 1.0 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 1.0 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 1.0 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 1.0 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 1.0 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764671 c.1302G>T synonymous_variant 1.0 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.98 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.95 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.96 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.95 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.9 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765004 c.1635G>T synonymous_variant 0.86 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1643delAGinsTC synonymous_variant 0.86 rifampicin
rpoC 765016 c.1647C>G synonymous_variant 0.87 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 765425 p.Lys686Glu missense_variant 0.88 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 0.92 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.91 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.88 rifampicin Uncertain significance
rpoC 765496 c.2127C>G synonymous_variant 0.9 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 765533 p.Tyr722His missense_variant 0.79 rifampicin Uncertain significance
rpoC 765793 c.2424C>G synonymous_variant 0.93 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.93 rifampicin
rpoC 765800 p.Phe811Leu missense_variant 0.93 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>C synonymous_variant 0.94 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.94 rifampicin
rpoC 765823 c.2454C>A synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.97 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.97 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.97 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.97 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.94 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.95 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>A synonymous_variant 0.95 rifampicin
rpoC 765961 c.2592G>T synonymous_variant 0.95 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.95 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 766345 c.2976T>C synonymous_variant 0.82 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.88 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.88 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.88 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.88 rifampicin
rpoC 766393 c.3024C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 766408 c.3039C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766618 c.3249G>T synonymous_variant 0.9 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.91 rifampicin
rpoC 766634 p.Phe1089Ile missense_variant 0.91 rifampicin
rpoC 766638 p.Lys1090Thr missense_variant 0.91 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.91 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.83 rifampicin
rpoC 766658 c.3289_3291delCGGinsGC frameshift_variant&missense_variant 0.83 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.88 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 0.88 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.8 rifampicin
rpoC 766694 c.3325_3327delCAGinsGC frameshift_variant&missense_variant 0.73 rifampicin
rpoC 766702 c.3333G>C synonymous_variant 0.81 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.84 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.84 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.84 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.86 rifampicin
rpoC 766732 c.3363G>T synonymous_variant 0.9 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.91 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.92 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.96 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.96 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.96 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766981 c.3612T>C synonymous_variant 1.0 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 767059 c.3690T>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoC 767068 c.3699G>C synonymous_variant 0.97 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.95 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.86 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.82 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.9 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.89 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767281 c.3912C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 767296 c.3927C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767302 c.3933C>G synonymous_variant 0.9 rifampicin
mmpL5 775850 c.2631C>T synonymous_variant 0.73 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.83 clofazimine
bedaquiline
mmpL5 775862 c.2619G>C synonymous_variant 0.85 clofazimine
bedaquiline
mmpL5 775865 c.2616T>G synonymous_variant 0.85 clofazimine
bedaquiline
mmpL5 775886 c.2595A>T synonymous_variant 0.87 clofazimine
bedaquiline
mmpL5 775893 p.His863Pro missense_variant 0.72 clofazimine
bedaquiline
mmpL5 775895 c.2584_2586delATCinsCG frameshift_variant&missense_variant 0.69 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775898 c.2583G>A synonymous_variant 0.69 clofazimine
bedaquiline
mmpL5 775904 p.Lys859Arg missense_variant 0.69 clofazimine
bedaquiline
mmpL5 775910 c.2571G>C synonymous_variant 0.85 clofazimine
bedaquiline
mmpL5 775913 c.2568C>G synonymous_variant 0.85 clofazimine
bedaquiline
mmpL5 775916 c.2565T>G synonymous_variant 0.88 clofazimine
bedaquiline
mmpL5 776039 c.2440_2442delGCCinsAA frameshift_variant&missense_variant 0.9 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776051 c.2428_2430delTTGinsGC frameshift_variant&missense_variant 0.85 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776056 p.Val809Leu missense_variant 0.71 clofazimine
bedaquiline
mmpL5 776072 c.2409C>G synonymous_variant 0.95 clofazimine
bedaquiline
mmpL5 776075 c.2406C>G synonymous_variant 0.91 clofazimine
bedaquiline
mmpL5 776084 c.2397C>G synonymous_variant 0.71 clofazimine
bedaquiline
mmpL5 776087 c.2392_2394delGTCinsTG frameshift_variant&synonymous_variant 0.88 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776090 c.2391C>T synonymous_variant 0.62 clofazimine
bedaquiline
mmpL5 776096 c.2385C>G synonymous_variant 0.62 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 0.96 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776132 c.2349A>C synonymous_variant 0.78 clofazimine
bedaquiline
mmpL5 776678 c.1803G>C synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 776683 p.Leu600Met missense_variant 1.0 clofazimine
bedaquiline
mmpL5 776686 p.Ser599Ala missense_variant 1.0 clofazimine
bedaquiline
mmpL5 776693 c.1786_1788delGTCinsAG frameshift_variant&missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776715 p.Lys589Pro missense_variant 1.0 clofazimine
bedaquiline
mmpL5 776726 c.1753_1755delTTCinsCG frameshift_variant&missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776733 p.Ser583Asn missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776741 c.1740C>G synonymous_variant 1.0 clofazimine
bedaquiline
mmpL5 776744 c.1737C>G synonymous_variant 1.0 clofazimine
bedaquiline
rpsL 781595 c.36T>C synonymous_variant 1.0 streptomycin
rpsL 781598 c.39G>C synonymous_variant 1.0 streptomycin
rpsL 781605 p.Ile16Val missense_variant 1.0 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 1.0 streptomycin
rpsL 781616 c.57C>G synonymous_variant 1.0 streptomycin
rpsL 781622 c.63C>G synonymous_variant 1.0 streptomycin
rpsL 781631 c.72G>C synonymous_variant 1.0 streptomycin
rpsL 781649 c.90T>C synonymous_variant 1.0 streptomycin
rpsL 781652 c.93T>C synonymous_variant 1.0 streptomycin
rpsL 781658 c.99A>G synonymous_variant 1.0 streptomycin
rpsL 781664 c.105C>G synonymous_variant 1.0 streptomycin
rpsL 781667 c.108C>T synonymous_variant 0.95 streptomycin
rpsL 781709 c.150G>C synonymous_variant 1.0 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 1.0 streptomycin
rpsL 781718 c.159C>G synonymous_variant 1.0 streptomycin
rpsL 781728 c.169T>C synonymous_variant 1.0 streptomycin
rpsL 781732 c.174_177delGAGT frameshift_variant 1.0 streptomycin Uncertain significance
rpsL 781739 c.180_181insCGGC frameshift_variant 1.0 streptomycin Uncertain significance
rpsL 781742 c.183C>T synonymous_variant 1.0 streptomycin
rpsL 781751 c.192G>C synonymous_variant 1.0 streptomycin
rpsL 781754 c.195G>C synonymous_variant 1.0 streptomycin
rpsL 781760 c.201T>C synonymous_variant 1.0 streptomycin
rpsL 781817 c.258G>T synonymous_variant 1.0 streptomycin
rpsL 781829 c.270G>C synonymous_variant 1.0 streptomycin
rpsL 781832 c.273T>C synonymous_variant 1.0 streptomycin
rpsL 781835 c.276T>C synonymous_variant 1.0 streptomycin Not assoc w R - Interim
rpsL 781838 c.279G>C synonymous_variant 1.0 streptomycin
rpsL 781841 c.282C>T synonymous_variant 1.0 streptomycin
rpsL 781859 c.300T>G synonymous_variant 1.0 streptomycin
rpsL 781865 c.306G>C synonymous_variant 1.0 streptomycin
rpsL 781868 c.309T>C synonymous_variant 1.0 streptomycin
rpsL 781871 c.312G>C synonymous_variant 1.0 streptomycin
rpsL 781892 c.333A>G synonymous_variant 1.0 streptomycin
rpsL 781898 c.339A>C synonymous_variant 1.0 streptomycin
rpsL 781901 c.342C>T synonymous_variant 1.0 streptomycin
rpsL 781907 c.348T>C synonymous_variant 1.0 streptomycin
rpsL 781916 c.357T>C synonymous_variant 1.0 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 1.0 streptomycin Uncertain significance
rplC 800546 c.-263T>C upstream_gene_variant 0.8 linezolid
rplC 800555 c.-254C>A upstream_gene_variant 0.8 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.8 linezolid
rplC 800603 c.-206G>C upstream_gene_variant 1.0 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 1.0 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 1.0 linezolid
rplC 800642 c.-167C>T upstream_gene_variant 1.0 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 1.0 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 1.0 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 1.0 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 1.0 linezolid
rplC 800684 c.-125G>A upstream_gene_variant 1.0 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 1.0 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 1.0 linezolid
rplC 800702 c.-107G>A upstream_gene_variant 1.0 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 1.0 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 1.0 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 1.0 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 1.0 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 1.0 linezolid
rplC 800753 c.-56C>T upstream_gene_variant 1.0 linezolid
rplC 800916 c.108A>G synonymous_variant 1.0 linezolid
rplC 800921 p.Arg38Leu missense_variant 1.0 linezolid
rplC 800928 c.120C>T synonymous_variant 1.0 linezolid
rplC 800931 c.123G>C synonymous_variant 1.0 linezolid
rplC 800937 c.129A>G synonymous_variant 0.94 linezolid
rplC 800946 c.138T>C synonymous_variant 0.9 linezolid
rplC 800949 c.141T>C synonymous_variant 0.9 linezolid
rplC 800964 c.156G>C synonymous_variant 0.92 linezolid
rplC 800985 c.177A>G synonymous_variant 0.93 linezolid
rplC 801003 c.195G>C synonymous_variant 0.89 linezolid
rplC 801004 c.196_198delCTGinsGC frameshift_variant&missense_variant 0.89 linezolid
rplC 801009 c.201A>C synonymous_variant 0.84 linezolid
rplC 801019 p.Thr71Ala missense_variant 0.8 linezolid
rplC 801027 c.219C>G synonymous_variant 0.78 linezolid
rplC 801030 c.222C>T synonymous_variant 0.75 linezolid
rplC 801039 c.231A>G synonymous_variant 0.79 linezolid
rplC 801045 c.237A>C synonymous_variant 0.8 linezolid
rplC 801046 p.Tyr80His missense_variant 0.8 linezolid
rplC 801171 c.363A>G synonymous_variant 0.8 linezolid
rplC 801174 c.366T>C synonymous_variant 0.8 linezolid
rplC 801195 c.387G>T synonymous_variant 0.79 linezolid
rplC 801205 p.Arg133Lys missense_variant 0.7 linezolid
rplC 801219 c.411C>T synonymous_variant 0.73 linezolid
rplC 801220 p.Ser138Ala missense_variant 0.73 linezolid
rplC 801237 c.429G>C synonymous_variant 0.9 linezolid
rplC 801246 c.438C>T synonymous_variant 0.83 linezolid
rplC 801252 c.444G>C synonymous_variant 0.83 linezolid
fbiC 1303492 c.562T>C synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fbiC 1303531 p.Met201Leu missense_variant 0.88 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1303548 c.618G>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1303551 c.621G>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1303974 c.1044C>T synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1304001 c.1071C>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1304013 c.1083G>T synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304019 c.1089C>T synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304465 p.Gly512Asp missense_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1304472 c.1542T>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1304481 c.1551T>G synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fbiC 1304490 c.1560C>A synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fbiC 1304493 c.1563C>T synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fbiC 1304496 c.1566T>A synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fbiC 1304499 c.1569T>C synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fbiC 1304515 p.Ala529Thr missense_variant 0.93 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>G synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1304562 c.1632G>C synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1304571 c.1641G>C synonymous_variant 0.97 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.97 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.75 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1304700 c.1770G>A synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fbiC 1304709 c.1779C>G synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>T synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.92 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.97 clofazimine
pretomanid
delamanid
fbiC 1304751 c.1821C>G synonymous_variant 0.97 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>T synonymous_variant 0.97 clofazimine
pretomanid
delamanid
fbiC 1304760 c.1830G>C synonymous_variant 0.97 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304772 c.1842C>T synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304784 c.1854T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1304802 c.1872G>C synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1305360 c.2430G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305361 c.2431C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305381 c.2451G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305393 c.2463T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305396 c.2466C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305399 c.2469A>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305400 p.His824Asn missense_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 1.0 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305417 c.2487C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305420 c.2490C>G synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305423 c.2493T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
fbiC 1305429 c.2499G>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
sigE 1364757 c.345G>A synonymous_variant 1.0 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.92 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 1.0 pyrazinamide
sigE 1364778 c.366G>C synonymous_variant 0.95 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.96 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.96 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.96 pyrazinamide
sigE 1364818 c.406_408delCTAinsTG frameshift_variant&stop_gained 0.96 pyrazinamide Uncertain significance
sigE 1364839 c.427T>C synonymous_variant 0.96 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.95 pyrazinamide
sigE 1364859 c.447C>T synonymous_variant 0.95 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.82 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.79 pyrazinamide
sigE 1364883 c.471G>A synonymous_variant 0.8 pyrazinamide
sigE 1365018 c.606G>C synonymous_variant 0.75 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.82 pyrazinamide
sigE 1365063 c.651A>G synonymous_variant 0.8 pyrazinamide
sigE 1365072 c.660G>C synonymous_variant 0.8 pyrazinamide
sigE 1365075 c.663G>A synonymous_variant 0.8 pyrazinamide
sigE 1365081 c.669G>C synonymous_variant 0.8 pyrazinamide
sigE 1365087 c.675A>G synonymous_variant 0.8 pyrazinamide
sigE 1365090 c.678T>C synonymous_variant 0.8 pyrazinamide
atpE 1461137 c.93C>G synonymous_variant 1.0 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 1.0 bedaquiline
atpE 1461155 c.111C>G synonymous_variant 0.92 bedaquiline
atpE 1461158 c.114T>C synonymous_variant 0.92 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.92 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.94 bedaquiline
atpE 1461179 c.135G>C synonymous_variant 0.94 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.89 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.94 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.95 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.95 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.82 bedaquiline
atpE 1461224 c.180T>G synonymous_variant 0.79 bedaquiline
atpE 1461230 c.186G>C synonymous_variant 0.73 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.73 bedaquiline
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.98 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.98 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.98 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472037 n.192_193insCTTCC non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.97 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472337 n.492C>G non_coding_transcript_exon_variant 0.91 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.99 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.99 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1473717 n.60G>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473811 n.154C>T non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1473833 n.176G>A non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473922 n.265A>G non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1473935 n.278C>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1474091 n.434C>T non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1474096 n.439C>T non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474102 n.445_446insTGAAC non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474106 n.449_453delATCAAinsG non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.98 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476731 n.3074G>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1476746 n.3089T>C non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1476750 n.3093T>C non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
inhA 1673691 c.-511G>C upstream_gene_variant 0.83 ethionamide
isoniazid
inhA 1673692 c.-510C>T upstream_gene_variant 0.83 ethionamide
isoniazid
inhA 1673709 c.-493C>G upstream_gene_variant 0.92 ethionamide
isoniazid
fabG1 1673710 c.271_273delCTAinsAC frameshift_variant&missense_variant 0.92 ethionamide
isoniazid
fabG1 1673716 p.Ala93Gln missense_variant 0.92 ethionamide
isoniazid
inhA 1673721 c.-481C>T upstream_gene_variant 0.92 ethionamide
isoniazid
inhA 1673724 c.-478A>G upstream_gene_variant 0.93 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.94 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.94 ethionamide
isoniazid
fabG1 1673760 p.Lys107Asn missense_variant 0.94 ethionamide
isoniazid
inhA 1673772 c.-430C>G upstream_gene_variant 0.93 ethionamide
isoniazid
inhA 1674471 c.270G>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.86 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.89 ethionamide
isoniazid
inhA 1674514 p.Ile105Val missense_variant 0.88 ethionamide
isoniazid
inhA 1674531 c.330C>T synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674534 c.333G>C synonymous_variant 0.91 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674537 c.336C>G synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.91 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.91 ethionamide
isoniazid
inhA 1674573 c.372G>A synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.89 ethionamide
isoniazid
inhA 1674601 p.Leu134Ala missense_variant 0.91 ethionamide
isoniazid
inhA 1674610 p.Ile137Val missense_variant 0.92 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674628 c.427_428delTCinsAG synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674639 c.438C>A synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.88 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674813 c.612C>T synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674816 c.615T>G synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.93 ethionamide
isoniazid
inhA 1674827 p.Glu209Ala missense_variant 0.93 ethionamide
isoniazid
inhA 1674839 p.Ala213Asp missense_variant 0.94 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.94 ethionamide
isoniazid
inhA 1674848 p.Gln216Arg missense_variant 0.95 ethionamide
isoniazid Uncertain significance
inhA 1674858 c.657G>A synonymous_variant 0.96 ethionamide
isoniazid
inhA 1674864 c.663C>T synonymous_variant 0.96 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674879 c.678T>A synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674883 p.Ile228Val missense_variant 0.95 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674904 p.Ala235Pro missense_variant 0.95 ethionamide
isoniazid
inhA 1674924 c.723G>C synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674930 c.729C>T synonymous_variant 1.0 ethionamide
isoniazid
inhA 1674942 c.741T>C synonymous_variant 1.0 ethionamide
isoniazid
rpsA 1833547 c.6G>A synonymous_variant 0.82 pyrazinamide
rpsA 1833554 p.Thr5Ser missense_variant 0.86 pyrazinamide
rpsA 1833557 p.Val6Ile missense_variant 0.88 pyrazinamide
rpsA 1833578 p.Val13Ile missense_variant 0.93 pyrazinamide
rpsA 1833589 c.48A>T synonymous_variant 0.96 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.96 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.96 pyrazinamide
rpsA 1833616 c.75A>G synonymous_variant 0.97 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.96 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.96 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.96 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.94 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.95 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.95 pyrazinamide
rpsA 1833688 c.147C>T synonymous_variant 0.95 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.95 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.95 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833730 c.189C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833734 c.193_195delGCCinsTT frameshift_variant&missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1833745 c.204G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833772 c.231C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.96 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.97 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.97 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.97 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.97 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.97 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.97 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.98 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.98 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.98 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.98 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.96 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.98 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.98 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.98 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.98 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 1.0 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 1.0 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.97 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.95 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.95 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.95 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.95 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.95 pyrazinamide
rpsA 1834168 c.627C>T synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
rpsA 1834169 p.Thr210Ala missense_variant 0.95 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.96 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.98 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.98 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.98 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.98 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.98 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.98 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 1.0 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.96 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.96 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.96 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.95 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.95 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.95 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.98 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834556 p.Ala339Thr missense_variant 1.0 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 1.0 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.96 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.97 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.97 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.98 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.88 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.82 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.71 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.69 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.69 pyrazinamide
rpsA 1834774 c.1233C>G synonymous_variant 0.64 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.92 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.91 linezolid
tsnR 1853375 c.-231G>T upstream_gene_variant 0.91 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.91 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.91 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.91 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.91 linezolid
katG 2155628 p.Ala162Ser missense_variant 0.64 isoniazid
katG 2155632 c.480A>G synonymous_variant 0.86 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.9 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.64 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.67 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.86 isoniazid
katG 2155698 c.414C>T synonymous_variant 0.67 isoniazid Not assoc w R - Interim
katG 2155716 c.396T>C synonymous_variant 0.89 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 1.0 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 1.0 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 1.0 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 1.0 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 1.0 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 1.0 isoniazid
kasA 2518732 c.618C>G synonymous_variant 1.0 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.93 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.93 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.94 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.94 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.94 isoniazid
kasA 2518785 p.Glu224Ala missense_variant 0.94 isoniazid
kasA 2518787 p.Arg225Gly missense_variant 0.94 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.94 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.89 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.89 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.93 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.95 isoniazid
ahpC 2726609 c.417C>T synonymous_variant 0.95 isoniazid
ahpC 2726624 c.432C>T synonymous_variant 0.96 isoniazid Not assoc w R - Interim
ahpC 2726638 p.Ala149Val missense_variant 1.0 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 1.0 isoniazid
ahpC 2726675 c.483A>T synonymous_variant 1.0 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 1.0 isoniazid Not assoc w R - Interim
ahpC 2726693 c.501C>G synonymous_variant 1.0 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 1.0 isoniazid
ahpC 2726709 c.517C>T synonymous_variant 1.0 isoniazid
ahpC 2726717 c.525A>C synonymous_variant 1.0 isoniazid
folC 2747059 c.540T>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747062 c.537A>G synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747071 c.528C>G synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747074 c.525G>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747083 c.516G>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747086 c.513A>G synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747089 c.510G>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747092 c.507C>T synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747097 p.Val168Ile missense_variant 1.0 para-aminosalicylic_acid
folC 2747107 c.492G>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747110 c.489T>C synonymous_variant 1.0 para-aminosalicylic_acid
folC 2747134 c.465C>G synonymous_variant 0.83 para-aminosalicylic_acid
folC 2747137 c.462G>C synonymous_variant 0.83 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783344 c.699C>G synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783386 c.657G>C synonymous_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783634 p.Leu137Ile missense_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783650 p.His131Ala missense_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783671 p.Arg124His missense_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783689 c.354G>C synonymous_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2681 2996236 c.-503C>G upstream_gene_variant 0.82 capreomycin
Rv2681 2996239 c.-500C>T upstream_gene_variant 0.82 capreomycin
Rv2681 2996242 c.-497T>G upstream_gene_variant 0.82 capreomycin
Rv2681 2996245 c.-494C>A upstream_gene_variant 0.82 capreomycin
Rv2681 2996248 c.-491A>T upstream_gene_variant 0.82 capreomycin
Rv2680 2996254 c.150G>A synonymous_variant 0.9 capreomycin Not assoc w R - Interim
Rv2681 2996263 c.-476A>G upstream_gene_variant 0.9 capreomycin
Rv2681 2996266 c.-473T>G upstream_gene_variant 0.9 capreomycin
Rv2681 2996269 c.-470G>T upstream_gene_variant 0.9 capreomycin
Rv2681 2996287 c.-452A>C upstream_gene_variant 0.9 capreomycin
thyX 3067340 c.606G>A synonymous_variant 0.82 para-aminosalicylic_acid
thyX 3067355 c.591A>G synonymous_variant 0.89 para-aminosalicylic_acid
thyX 3067364 c.582C>T synonymous_variant 0.9 para-aminosalicylic_acid
thyX 3067367 c.579G>T synonymous_variant 0.9 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.9 para-aminosalicylic_acid
thyX 3067388 c.558C>G synonymous_variant 0.95 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.95 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.95 para-aminosalicylic_acid
thyX 3067430 c.516C>G synonymous_variant 0.88 para-aminosalicylic_acid
thyX 3067442 c.504C>A synonymous_variant 0.82 para-aminosalicylic_acid
thyA 3073950 c.522G>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073953 c.519T>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073962 c.510G>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073968 c.504C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073980 c.492C>T synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073983 c.489C>G synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073993 c.478_479delAGinsTC synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3073999 p.Arg158Lys missense_variant 1.0 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 1.0 para-aminosalicylic_acid
thyA 3074199 c.273G>C synonymous_variant 0.9 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.93 para-aminosalicylic_acid
thyA 3074214 p.Asp86Glu missense_variant 0.94 para-aminosalicylic_acid
thyA 3074220 c.252A>C synonymous_variant 0.94 para-aminosalicylic_acid
thyA 3074229 c.243C>T synonymous_variant 0.94 para-aminosalicylic_acid
thyA 3074268 c.204T>C synonymous_variant 0.8 para-aminosalicylic_acid
thyA 3074271 c.201C>G synonymous_variant 0.8 para-aminosalicylic_acid
lpqB 3624643 p.Ile90Leu missense_variant 1.0 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624671 c.240C>T synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624675 p.Asn79Ser missense_variant 1.0 bedaquiline
rifampicin
lpqB 3624680 c.231T>C synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624686 c.225A>G synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624701 c.210T>G synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 1.0 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 1.0 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625240 c.-330T>C upstream_gene_variant 0.9 bedaquiline
rifampicin
lpqB 3625243 c.-333T>C upstream_gene_variant 0.9 bedaquiline
rifampicin
lpqB 3625246 c.-336G>C upstream_gene_variant 0.9 bedaquiline
rifampicin
lpqB 3625252 c.-342G>T upstream_gene_variant 0.9 bedaquiline
rifampicin
lpqB 3625255 c.-345T>C upstream_gene_variant 0.9 bedaquiline
rifampicin
lpqB 3625258 c.-348G>C upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrB 3625262 p.Tyr451Phe missense_variant 0.9 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.9 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.9 bedaquiline
rifampicin
lpqB 3625273 c.-363C>G upstream_gene_variant 0.91 bedaquiline
rifampicin
lpqB 3625285 c.-375G>C upstream_gene_variant 0.88 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.88 bedaquiline
rifampicin
lpqB 3625312 c.-402G>C upstream_gene_variant 0.86 bedaquiline
rifampicin
lpqB 3625318 c.-408G>C upstream_gene_variant 0.8 bedaquiline
rifampicin
lpqB 3625336 c.-426C>T upstream_gene_variant 0.8 bedaquiline
rifampicin
lpqB 3625345 c.-435T>C upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrB 3625351 c.1263T>C synonymous_variant 0.73 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625354 c.-444G>C upstream_gene_variant 0.73 bedaquiline
rifampicin
lpqB 3625357 c.-447T>C upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.83 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.82 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625744 c.870G>A synonymous_variant 0.82 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.75 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.75 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625753 p.Ala287Gln missense_variant 0.75 bedaquiline
rifampicin
mtrB 3625762 c.852A>T synonymous_variant 0.79 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625768 c.-858G>C upstream_gene_variant 0.8 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.81 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626684 c.-71G>A upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 1.0 bedaquiline
rifampicin
mtrA 3626711 p.Thr213Gln missense_variant 1.0 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 0.94 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrA 3626749 c.601C>T synonymous_variant 0.96 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626750 c.-137T>G upstream_gene_variant 0.96 bedaquiline
rifampicin
mtrB 3626773 c.-160C>T upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCT frameshift_variant&missense_variant 0.89 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.89 bedaquiline
rifampicin
mtrB 3626786 c.-173A>C upstream_gene_variant 0.89 bedaquiline
rifampicin
mtrB 3626792 c.-179G>C upstream_gene_variant 0.89 bedaquiline
rifampicin
mtrB 3626795 c.-182C>T upstream_gene_variant 0.89 bedaquiline
rifampicin
mtrB 3626798 c.-185T>A upstream_gene_variant 0.89 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.91 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877545 c.963G>C synonymous_variant 1.0 rifampicin
rpoA 3877548 c.960C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877554 c.954G>C synonymous_variant 1.0 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877566 p.Ser314Thr missense_variant 1.0 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 1.0 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877590 c.918G>C synonymous_variant 0.94 rifampicin
rpoA 3877593 c.915C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3877602 c.906C>T synonymous_variant 0.96 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.96 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.96 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.96 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.96 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.9 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.82 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.82 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.82 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877758 c.750G>C synonymous_variant 0.8 rifampicin
rpoA 3877782 c.726T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.8 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.94 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.95 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>C synonymous_variant 0.92 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.87 rifampicin
rpoA 3877929 c.579C>T synonymous_variant 0.86 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877965 c.543C>G synonymous_variant 0.82 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.8 rifampicin Uncertain significance
rpoA 3877974 c.534G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoA 3878878 c.-371T>C upstream_gene_variant 0.79 rifampicin Uncertain significance
rpoA 3878881 c.-374C>G upstream_gene_variant 0.79 rifampicin
rpoA 3878886 c.-379G>A upstream_gene_variant 0.79 rifampicin Uncertain significance
rpoA 3878890 c.-383C>G upstream_gene_variant 0.79 rifampicin
rpoA 3878893 c.-388_-386delCACinsAG upstream_gene_variant 0.79 rifampicin
rpoA 3878896 c.-389G>C upstream_gene_variant 0.79 rifampicin
rpoA 3878899 c.-392C>T upstream_gene_variant 0.79 rifampicin
rpoA 3878909 c.-402A>C upstream_gene_variant 0.81 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.81 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.81 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.78 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.8 rifampicin Uncertain significance
clpC1 4038347 c.2358G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038353 c.2352G>A synonymous_variant 1.0 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 1.0 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 1.0 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038410 c.2295C>T synonymous_variant 1.0 pyrazinamide
clpC1 4038416 c.2289C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038551 c.2154C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038584 c.2121G>T synonymous_variant 0.95 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.95 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.94 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.93 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.94 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.91 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.85 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.88 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.88 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.88 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.88 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.88 pyrazinamide
clpC1 4038776 c.1929G>A synonymous_variant 0.88 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.88 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.9 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.97 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.97 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 1.0 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.92 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.91 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.9 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.9 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.9 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.91 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.93 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.95 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.92 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.9 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.9 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.94 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.91 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.91 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.92 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.9 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.9 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.91 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.89 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.89 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.89 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.94 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.94 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.94 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.96 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.96 pyrazinamide
clpC1 4039238 c.1467C>T synonymous_variant 0.95 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039265 c.1440C>T synonymous_variant 0.94 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.93 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.89 pyrazinamide
clpC1 4039319 p.Ala462Gly missense_variant 0.91 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.94 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.91 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.91 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.91 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.97 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.95 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.91 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.93 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.93 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4039592 c.1113G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039610 c.1095G>T synonymous_variant 0.97 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.96 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.98 pyrazinamide
clpC1 4039691 c.1014G>T synonymous_variant 0.95 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.96 pyrazinamide
clpC1 4039733 c.972G>T synonymous_variant 0.9 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039754 c.951G>T synonymous_variant 0.93 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4039766 c.939T>C synonymous_variant 0.85 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.9 pyrazinamide
clpC1 4039814 c.891C>T synonymous_variant 0.92 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.92 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.92 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.92 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.92 pyrazinamide
clpC1 4039840 c.865C>T synonymous_variant 0.95 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.95 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 1.0 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 1.0 pyrazinamide
clpC1 4039913 c.792C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039925 c.780C>T synonymous_variant 0.98 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.98 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.97 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.97 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.97 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.96 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.96 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.95 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.96 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.97 pyrazinamide
clpC1 4040057 c.648C>T synonymous_variant 0.98 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.94 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
clpC1 4040123 c.582G>A synonymous_variant 0.92 pyrazinamide
clpC1 4040126 c.579C>T synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4040195 c.510G>C synonymous_variant 0.7 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.88 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.87 pyrazinamide
clpC1 4040258 c.447G>A synonymous_variant 0.89 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>A synonymous_variant 0.91 pyrazinamide
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.91 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.94 pyrazinamide
clpC1 4040303 c.402G>C synonymous_variant 0.95 pyrazinamide
clpC1 4040306 c.399G>T synonymous_variant 0.95 pyrazinamide
clpC1 4040309 c.396C>G synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4040318 c.387C>T synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4040342 c.363C>G synonymous_variant 0.98 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 1.0 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 1.0 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 1.0 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 1.0 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.97 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.97 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.96 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.95 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4040441 c.264C>G synonymous_variant 0.82 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.82 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.88 pyrazinamide
clpC1 4040462 c.243C>G synonymous_variant 0.89 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.89 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>T synonymous_variant 0.95 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>C synonymous_variant 0.92 pyrazinamide
clpC1 4040495 c.210C>G synonymous_variant 0.96 pyrazinamide
clpC1 4040501 c.204C>G synonymous_variant 0.96 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.91 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.82 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.73 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.67 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.64 pyrazinamide
clpC1 4040618 c.87C>G synonymous_variant 0.75 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.88 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.91 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
clpC1 4040690 c.15T>C synonymous_variant 0.83 pyrazinamide
clpC1 4040695 c.10C>A synonymous_variant 0.83 pyrazinamide
clpC1 4040696 c.9A>G synonymous_variant 0.83 pyrazinamide
clpC1 4040699 c.6C>T synonymous_variant 0.77 pyrazinamide
clpC1 4040711 c.-7G>A upstream_gene_variant 0.83 pyrazinamide
panD 4044965 c.-684T>C upstream_gene_variant 0.82 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.82 pyrazinamide
panD 4044983 c.-702G>C upstream_gene_variant 0.82 pyrazinamide
panD 4044986 c.-705C>G upstream_gene_variant 0.82 pyrazinamide
panD 4044989 c.-708T>G upstream_gene_variant 0.82 pyrazinamide
panD 4044995 c.-714A>G upstream_gene_variant 0.83 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.91 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.91 pyrazinamide
panD 4045025 c.-744C>G upstream_gene_variant 0.91 pyrazinamide
panD 4045033 c.-752T>G upstream_gene_variant 0.91 pyrazinamide
panD 4045034 c.-753A>T upstream_gene_variant 0.91 pyrazinamide
panD 4045040 c.-759G>T upstream_gene_variant 0.91 pyrazinamide
glpK 4138661 c.1095T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138676 c.1080T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138696 p.Pro354Ala missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138697 c.1059C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1051_1053delCGCinsAG frameshift_variant&missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138718 c.1038T>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138727 c.1029C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138775 c.981C>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138799 c.957T>A synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138808 c.948G>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138817 c.937_939delGCTinsTG frameshift_variant&missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138822 p.Asn312Asp missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138823 c.933G>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138829 c.927A>G synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138847 c.909A>C synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139585 c.171G>A synonymous_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139594 c.162C>G synonymous_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Gln missense_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139617 p.Glu47Gln missense_variant 0.95 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139630 c.126C>T synonymous_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139637 p.Ala40Gly missense_variant 0.95 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139652 p.His35Ala missense_variant 0.94 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139654 c.102C>T synonymous_variant 0.93 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139672 c.84C>G synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239486 c.-377T>C upstream_gene_variant 0.8 ethambutol
embC 4239524 c.-339C>T upstream_gene_variant 0.92 ethambutol
embC 4239526 c.-337_-336delGGinsAC upstream_gene_variant 0.92 ethambutol
embC 4239530 c.-333C>G upstream_gene_variant 0.92 ethambutol
embC 4239533 c.-330T>C upstream_gene_variant 0.92 ethambutol
embC 4239539 c.-324G>C upstream_gene_variant 0.92 ethambutol
embC 4239540 c.-323T>C upstream_gene_variant 0.92 ethambutol
embC 4239546 c.-317C>T upstream_gene_variant 0.92 ethambutol
embC 4239569 c.-294A>C upstream_gene_variant 0.92 ethambutol
embC 4239570 c.-293C>G upstream_gene_variant 0.91 ethambutol
embC 4240702 c.840G>C synonymous_variant 0.85 ethambutol
embC 4240717 c.855T>C synonymous_variant 0.93 ethambutol
embC 4240736 p.Ser292Ala missense_variant 1.0 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.98 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.98 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.98 ethambutol
embC 4240819 c.957A>T synonymous_variant 0.93 ethambutol
embC 4240825 c.963G>A synonymous_variant 0.91 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.9 ethambutol
embB 4247440 c.927C>G synonymous_variant 1.0 ethambutol
embB 4247464 c.951C>G synonymous_variant 1.0 ethambutol
embB 4247470 c.957T>C synonymous_variant 1.0 ethambutol
embB 4247491 c.978G>C synonymous_variant 1.0 ethambutol
embB 4247494 c.981G>A synonymous_variant 1.0 ethambutol
embB 4247497 c.984T>C synonymous_variant 1.0 ethambutol
embB 4247500 c.987C>G synonymous_variant 1.0 ethambutol
embB 4247511 p.Tyr333Phe missense_variant 1.0 ethambutol
embB 4247527 c.1014G>C synonymous_variant 1.0 ethambutol
embB 4247554 c.1041T>C synonymous_variant 1.0 ethambutol
embB 4247555 c.1042_1044delCTGinsAC frameshift_variant&missense_variant 1.0 ethambutol
embB 4247566 c.1053C>G synonymous_variant 1.0 ethambutol
embB 4247572 c.1059A>C synonymous_variant 1.0 ethambutol
embB 4247579 p.Ala356Ile missense_variant 1.0 ethambutol
embB 4247582 p.Ala357Cys missense_variant 1.0 ethambutol
embB 4247586 p.Gly358Ala missense_variant 1.0 ethambutol
embB 4247590 c.1077A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247611 c.1098G>C synonymous_variant 1.0 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.91 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.91 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.92 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.93 ethambutol
embB 4248143 p.Leu544Met missense_variant 0.94 ethambutol
embB 4248157 c.1644A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248158 p.Cys549Ser missense_variant 1.0 ethambutol
embB 4248167 p.Thr552Ala missense_variant 1.0 ethambutol
embB 4248170 p.Ala553Ser missense_variant 1.0 ethambutol
embB 4248173 p.Val554Leu missense_variant 1.0 ethambutol
embB 4248199 c.1686A>G synonymous_variant 1.0 ethambutol
embB 4248200 p.Ile563Val missense_variant 1.0 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 1.0 ethambutol
embB 4248220 c.1707A>G synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4248225 p.Ala571Val missense_variant 1.0 ethambutol Uncertain significance
embB 4248242 p.Val577Ile missense_variant 0.96 ethambutol
embB 4248252 p.Gly580Ala missense_variant 1.0 ethambutol
embB 4248264 p.Phe584Cys missense_variant 0.95 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.95 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.94 ethambutol
embB 4248307 c.1794G>C synonymous_variant 0.92 ethambutol
embB 4248319 c.1806A>G synonymous_variant 1.0 ethambutol
embB 4248322 c.1809G>T synonymous_variant 1.0 ethambutol
embB 4249480 c.2967G>T synonymous_variant 0.73 ethambutol
embB 4249483 c.2970C>G synonymous_variant 0.73 ethambutol
embB 4249486 c.2973T>A synonymous_variant 0.73 ethambutol
embB 4249487 c.2974T>C synonymous_variant 0.73 ethambutol