TB-Profiler result

Run: ERR161034
Summary

Run ID: ERR161034

Sample name:

Date: 2024-04-14T23:17:17.301924

Number of reads: 3233309

Percentage reads mapped: 64.59

Median coverage: 72.0

Strain: lineage4.3.4.2.1

Spoligotype:

Drug-resistance: HR-TB

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.98
lineage4 Euro-American None 0.95
lineage4.3.4.2.1 Euro-American (LAM) RD174 0.91
lineage4.3.4 Euro-American (LAM) RD174 1.0
lineage4.3.4.2 Euro-American (LAM) RD174 0.86
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.451_453delGTCinsCG Assoc w R High-level resistance
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine pepQ c.640_641delGT Assoc w R - Interim
c.636_637insGC Assoc w R - Interim
c.592_594delGCCinsCG Assoc w R - Interim
c.562_564delGTGinsAC Assoc w R - Interim
para-aminosalicylic_acid
delamanid fgd1 c.796_798delATCinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline pepQ c.640_641delGT Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
c.636_637insGC Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
c.592_594delGCCinsCG Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
c.562_564delGTGinsAC Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491578 c.796_798delATCinsCG frameshift_variant&missense_variant 0.21 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance Mutation from literature
katG 2155659 c.451_453delGTCinsCG frameshift_variant&missense_variant 0.23 isoniazid Assoc w R High-level resistance
pepQ 2859777 c.640_641delGT frameshift_variant 0.2 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
pepQ 2859782 c.636_637insGC frameshift_variant 0.19 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
pepQ 2859825 c.592_594delGCCinsCG frameshift_variant&synonymous_variant 0.27 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
pepQ 2859855 c.562_564delGTGinsAC frameshift_variant&missense_variant 0.26 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
embB 4247448 p.His312Arg missense_variant 0.32 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 534 c.534T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 558 c.558G>C synonymous_variant 0.23 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.24 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 591 c.591C>G synonymous_variant 0.22 isoniazid
dnaA 597 c.597C>G synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 600 c.600T>C synonymous_variant 0.2 isoniazid
dnaA 609 c.609C>G synonymous_variant 0.16 isoniazid
dnaA 610 c.610_612delCTGinsTA frameshift_variant&stop_gained 0.16 isoniazid Uncertain significance
dnaA 741 c.741T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.2 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.19 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.19 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.21 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.2 isoniazid
dnaA 792 c.792C>T synonymous_variant 0.21 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.24 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.25 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.21 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.2 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.22 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.22 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.22 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.22 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 876 c.876C>G synonymous_variant 0.17 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 1023 c.1023C>T synonymous_variant 0.26 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.26 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.33 isoniazid
dnaA 1053 c.1053C>G synonymous_variant 0.33 isoniazid Not assoc w R - Interim
dnaA 1059 c.1059C>G synonymous_variant 0.36 isoniazid
dnaA 1077 c.1077A>G synonymous_variant 0.33 isoniazid
dnaA 1080 c.1080C>G synonymous_variant 0.32 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.21 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.18 isoniazid
dnaA 1140 c.1140C>G synonymous_variant 0.19 isoniazid
dnaA 1143 c.1143G>A synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1152 c.1152A>G synonymous_variant 0.18 isoniazid
dnaA 1153 c.1153_1155delTTGinsCC frameshift_variant&missense_variant 0.18 isoniazid Uncertain significance
dnaA 1161 c.1161A>G synonymous_variant 0.18 isoniazid
dnaA 1164 c.1164A>G synonymous_variant 0.19 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.21 isoniazid
dnaA 1179 c.1179G>C synonymous_variant 0.21 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.29 isoniazid
dnaA 1215 c.1215C>T synonymous_variant 0.33 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.31 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.27 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.26 isoniazid
dnaA 1254 c.1254T>G synonymous_variant 0.29 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.28 isoniazid
dnaA 1293 c.1293T>G synonymous_variant 0.23 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
gyrB 6127 c.888G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6133 c.894G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6140 p.Val301Leu missense_variant 0.8 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6307 c.1068T>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6394 c.-908G>A upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6397 c.1158G>A synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6403 c.-899T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6409 c.-893A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6412 c.-890G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6418 c.-884C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.26 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6764 c.-538C>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6775 c.-527G>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.23 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6802 c.1563G>A synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6838 c.-464C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6970 p.Asp577Glu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>T upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 7012 c.1773G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7021 c.-281G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 7030 c.-272C>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7415 c.114C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7442 c.141G>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7604 c.303G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7607 c.306C>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7626 c.325C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCC frameshift_variant&missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7733 c.432A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7775 c.474C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7778 c.477G>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7805 c.504C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7832 c.531G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7841 c.540C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7853 c.552C>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8126 c.825G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8129 c.828T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8174 c.873C>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8187 c.886C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8312 c.1011G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8513 c.1212C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8540 c.1239C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 p.Asp415Glu missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8558 c.1257C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8576 c.1275C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8792 c.1491G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8818 p.Ser506Asn missense_variant 0.28 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8882 c.1581G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8930 c.1629C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8965 c.1664_1665insG frameshift_variant 0.28 levofloxacin
moxifloxacin
gyrA 8968 c.1668delG frameshift_variant 0.27 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9104 c.1803C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9110 c.1809G>A synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.33 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9153 p.Thr618Glu missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9164 c.1863G>A synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9167 c.1866C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.34 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9284 c.1983T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 9332 c.2031C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9362 c.2061C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9365 c.2064G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>G synonymous_variant 0.25 levofloxacin
moxifloxacin
Rv0010c 13490 p.Met23Ile missense_variant 1.0 isoniazid Uncertain significance
Rv0010c 13890 c.-332T>C upstream_gene_variant 0.17 isoniazid
Rv0010c 13893 c.-335T>G upstream_gene_variant 0.19 isoniazid
Rv0010c 13903 c.-345A>G upstream_gene_variant 0.19 isoniazid
fgd1 490797 c.15G>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490800 c.18A>C synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490803 c.21T>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490854 c.72C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490962 c.180T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491022 c.240C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491110 p.Ala110Ser missense_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491115 c.333G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491310 c.528C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491320 p.Ala180Gln missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491337 c.555C>G synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491568 c.786C>T synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491601 c.819T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491603 p.Ala274Glu missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491640 c.858G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
mshA 575692 c.345G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575695 c.348C>T synonymous_variant 0.21 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.26 ethionamide
isoniazid
mshA 575725 c.378C>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575732 c.385_387delCTTinsTG frameshift_variant&missense_variant 0.24 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575737 c.390T>C synonymous_variant 0.25 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.24 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.26 ethionamide
isoniazid Not assoc w R - Interim
mshA 575812 c.465C>T synonymous_variant 0.31 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.36 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.37 ethionamide
isoniazid
mshA 575833 c.486C>T synonymous_variant 0.38 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575837 c.490C>T synonymous_variant 0.39 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575864 c.517T>C synonymous_variant 0.37 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.3 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.2 ethionamide
isoniazid
ccsA 619584 c.-307A>T upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>G upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>C upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620245 c.355T>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620257 p.Ile123Val missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620271 c.381C>T synonymous_variant 0.27 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620283 c.393T>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620311 c.421C>T synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620319 c.429C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>T synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.34 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.3 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>G synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>G synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620460 c.570T>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620461 p.Val191Ile missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>A synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620664 c.774C>T synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620697 c.807C>T synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620758 c.868_870delCGCinsAG frameshift_variant&missense_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620763 c.873G>A synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620781 c.891C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>A synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620790 c.900C>T synonymous_variant 0.19 capreomycin
amikacin
kanamycin
Rv0565c 656277 c.1194C>G synonymous_variant 0.16 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.18 ethionamide
Rv0565c 656298 c.1173G>C synonymous_variant 0.19 ethionamide
Rv0565c 656304 c.1167T>C synonymous_variant 0.2 ethionamide
Rv0565c 656307 c.1164G>C synonymous_variant 0.19 ethionamide
Rv0565c 656325 c.1146C>G synonymous_variant 0.21 ethionamide
Rv0565c 656349 c.1122G>A synonymous_variant 0.15 ethionamide
Rv0565c 656448 c.1023T>C synonymous_variant 0.2 ethionamide
Rv0565c 656454 c.1017G>C synonymous_variant 0.21 ethionamide
Rv0565c 656457 c.1014T>C synonymous_variant 0.21 ethionamide
Rv0565c 656466 c.1005G>A synonymous_variant 0.22 ethionamide
Rv0565c 656469 c.1002T>C synonymous_variant 0.22 ethionamide
Rv0565c 656475 c.996A>G synonymous_variant 0.22 ethionamide
Rv0565c 656481 c.990A>G synonymous_variant 0.2 ethionamide
Rv0565c 656484 c.987T>C synonymous_variant 0.21 ethionamide
Rv0565c 656487 c.984T>C synonymous_variant 0.23 ethionamide Not assoc w R - Interim
Rv0565c 656493 c.978C>G synonymous_variant 0.21 ethionamide
Rv0565c 656511 c.960T>C synonymous_variant 0.16 ethionamide Not assoc w R - Interim
Rv0565c 656835 c.636C>G synonymous_variant 0.19 ethionamide
Rv0565c 656838 c.633A>C synonymous_variant 0.19 ethionamide
Rv0565c 656853 c.618A>C synonymous_variant 0.2 ethionamide
Rv0565c 656859 p.Glu204Ala missense_variant 0.2 ethionamide
Rv0565c 656871 c.598_600delACCinsTG frameshift_variant&missense_variant 0.2 ethionamide Uncertain significance
Rv0565c 656876 c.595C>T synonymous_variant 0.21 ethionamide Not assoc w R - Interim
Rv0565c 656880 c.591C>G synonymous_variant 0.2 ethionamide
Rv0565c 656883 c.586_588delATCinsCG frameshift_variant&missense_variant 0.21 ethionamide Uncertain significance
Rv0565c 656889 c.582A>G synonymous_variant 0.2 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.21 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.17 ethionamide
hadA 731729 c.-201C>T upstream_gene_variant 0.23 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.25 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.27 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.39 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.38 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.36 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.36 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.27 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.18 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.18 isoniazid
hadA 731849 c.-81C>T upstream_gene_variant 0.17 isoniazid
hadA 732268 c.339T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
hadA 732272 c.343_345delGCGinsTA frameshift_variant&stop_gained 0.18 isoniazid Uncertain significance
hadA 732295 c.366G>C synonymous_variant 0.26 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.25 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.25 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.25 isoniazid
hadA 732319 c.390G>A synonymous_variant 0.24 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.24 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.27 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.29 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.26 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.35 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.34 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.34 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.27 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.31 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.31 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.35 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.38 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>T synonymous_variant 0.39 rifampicin
nusG 734502 c.249G>A synonymous_variant 0.34 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.32 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.25 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.23 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.22 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.24 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.24 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.24 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.21 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.18 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.16 rifampicin Uncertain significance
nusG 734820 c.567A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.22 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734847 c.594T>C synonymous_variant 0.31 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.3 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.28 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.28 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.3 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.33 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.3 rifampicin
nusG 734910 c.657C>G synonymous_variant 0.19 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.19 rifampicin
nusG 734931 c.678A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760085 c.279C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.33 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.38 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.4 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.28 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.35 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.36 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.36 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.38 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.33 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.34 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.34 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.31 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.39 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.4 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.32 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.37 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.42 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760643 c.837G>A synonymous_variant 0.37 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.38 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760817 c.1011A>G synonymous_variant 0.19 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.18 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.23 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.28 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.28 rifampicin
rpoB 760877 c.1071G>C synonymous_variant 0.33 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.37 rifampicin
rpoB 760892 c.1086C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>G synonymous_variant 0.32 rifampicin
rpoB 760920 c.1114C>T synonymous_variant 0.32 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.31 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.32 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.36 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.39 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.42 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.36 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.41 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.38 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>T synonymous_variant 0.26 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761361 c.1555_1556delAGinsTC synonymous_variant 0.22 rifampicin
rpoB 761372 c.1566C>T synonymous_variant 0.22 rifampicin
rpoB 761373 p.Val523His missense_variant 0.22 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.27 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.21 rifampicin
rpoB 761465 c.1659G>C synonymous_variant 0.17 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.15 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.29 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.31 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.38 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.4 rifampicin
rpoB 761615 c.1809A>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.27 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.22 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.19 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.2 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.18 rifampicin
rpoB 761867 c.2061C>T synonymous_variant 0.21 rifampicin
rpoB 761870 p.Asp688Glu missense_variant 0.2 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.22 rifampicin
rpoB 761876 c.2070C>G synonymous_variant 0.24 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.26 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.28 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.28 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.28 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.28 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.24 rifampicin
rpoB 762002 c.2196C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.27 rifampicin
rpoB 762020 c.2214G>A synonymous_variant 0.25 rifampicin
rpoB 762027 c.2221_2223delCTCinsTG frameshift_variant&missense_variant 0.2 rifampicin
rpoB 762032 c.2226C>G synonymous_variant 0.2 rifampicin
rpoB 762035 c.2229G>C synonymous_variant 0.2 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.34 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.38 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.38 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762197 c.2391C>T synonymous_variant 0.37 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.35 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.36 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>A synonymous_variant 0.36 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.31 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.33 rifampicin
rpoB 762353 c.2547C>G synonymous_variant 0.34 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.31 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.28 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.29 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.28 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.3 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.27 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762458 c.-912C>G upstream_gene_variant 0.26 rifampicin
rpoC 762470 c.-900G>T upstream_gene_variant 0.28 rifampicin
rpoB 762489 p.Val895Gln missense_variant 0.22 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.23 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 762521 c.-849C>G upstream_gene_variant 0.25 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.21 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.21 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.21 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.21 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.18 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.23 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.45 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.38 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.37 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.39 rifampicin
rpoC 763181 c.-189G>C upstream_gene_variant 0.39 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.33 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.3 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.3 rifampicin
rpoC 763226 c.-144A>G upstream_gene_variant 0.31 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.25 rifampicin
rpoC 763262 c.-108C>G upstream_gene_variant 0.23 rifampicin
rpoC 763402 c.33C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.42 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.43 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.41 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>T synonymous_variant 0.41 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.42 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.41 rifampicin
rpoC 763648 c.279C>T synonymous_variant 0.41 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.41 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.42 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.38 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.38 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.4 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.4 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>T synonymous_variant 0.34 rifampicin
rpoC 763819 c.450G>C synonymous_variant 0.32 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.32 rifampicin
rpoC 763853 c.484_486delGTCinsAT frameshift_variant&missense_variant 0.31 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.3 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.33 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.34 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.34 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.29 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.34 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.34 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763933 c.564C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763936 c.567C>G synonymous_variant 0.34 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.33 rifampicin
rpoC 763969 c.600C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.23 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.21 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.18 rifampicin
rpoC 763996 c.627T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764002 c.633C>G synonymous_variant 0.18 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.17 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.2 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.25 rifampicin
rpoC 764110 c.741C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764112 p.Tyr248Phe missense_variant 0.26 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.34 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>T synonymous_variant 0.31 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764213 p.Arg282Lys missense_variant 0.24 rifampicin Uncertain significance
rpoC 764257 c.888G>C synonymous_variant 0.29 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.28 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.27 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764359 c.990C>G synonymous_variant 0.34 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.26 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.31 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.24 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.23 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.24 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.21 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.22 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.28 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.42 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.42 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>G synonymous_variant 0.39 rifampicin
rpoC 764746 c.1377G>A synonymous_variant 0.44 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.42 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.33 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764971 c.1602C>G synonymous_variant 0.25 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 765287 c.1918C>T synonymous_variant 0.19 rifampicin
rpoC 765292 c.1923G>T synonymous_variant 0.19 rifampicin
rpoC 765319 c.1950A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.18 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.18 rifampicin Uncertain significance
rpoC 765346 c.1977C>T synonymous_variant 0.23 rifampicin
rpoC 765352 c.1983G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765370 c.2001G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765371 c.2002C>T synonymous_variant 0.19 rifampicin
rpoC 765376 c.2007C>T synonymous_variant 0.21 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.25 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.26 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.28 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.27 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.27 rifampicin
rpoC 765463 c.2094C>T synonymous_variant 0.29 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.3 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.38 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.37 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.36 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.4 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.4 rifampicin
rpoC 765592 c.2223C>T synonymous_variant 0.43 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.47 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.43 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.3 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.3 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.34 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.34 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.37 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.38 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.39 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.41 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.32 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.32 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766005 c.2637_2638delCG frameshift_variant 0.27 rifampicin
rpoC 766011 c.2642_2643insAG frameshift_variant 0.27 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.32 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.35 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.39 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.45 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.44 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.44 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.42 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.3 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.18 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766261 c.2892G>T synonymous_variant 0.15 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.22 rifampicin
rpoC 766279 c.2910C>T synonymous_variant 0.26 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.27 rifampicin
rpoC 766294 c.2925C>T synonymous_variant 0.34 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.38 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.36 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.32 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.3 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.27 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.29 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.31 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.3 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.33 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.33 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.38 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.42 rifampicin
rpoC 766469 c.3100C>T synonymous_variant 0.41 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.35 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.35 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.38 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.34 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.35 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.33 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.38 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.37 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.39 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.37 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.33 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.32 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.32 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.38 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.3 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.28 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.29 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.31 rifampicin
rpoC 766682 p.Val1105Ile missense_variant 0.31 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.28 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.29 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.32 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.41 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766816 c.3447C>T synonymous_variant 0.37 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.4 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.35 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.35 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.34 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.34 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.39 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.39 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.38 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.38 rifampicin
rpoC 767066 c.3697C>T synonymous_variant 0.38 rifampicin
rpoC 767080 c.3711G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.32 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.32 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.29 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.23 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.2 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775922 c.2559G>C synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 775940 c.2541C>T synonymous_variant 0.22 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.25 clofazimine
bedaquiline
mmpL5 775973 c.2506_2508delTTGinsCC frameshift_variant&missense_variant 0.22 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775981 p.Leu834Met missense_variant 0.21 clofazimine
bedaquiline
mmpL5 776000 c.2479_2481delCTGinsAC frameshift_variant&missense_variant 0.17 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776003 p.Ile826Met missense_variant 0.17 clofazimine
bedaquiline
mmpL5 776021 c.2460G>A synonymous_variant 0.15 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.16 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.24 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.24 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.24 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.23 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.29 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.32 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.34 streptomycin
rpsL 781676 c.117C>G synonymous_variant 0.37 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.41 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.41 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.45 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.44 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.42 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.45 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.33 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.33 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.33 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.31 streptomycin
rpsL 781829 c.270G>T synonymous_variant 0.32 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.29 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.29 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.3 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.27 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.26 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.24 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.27 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.3 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.3 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.3 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.3 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.17 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.29 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.31 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.35 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.37 linezolid
rplC 800594 c.-215C>T upstream_gene_variant 0.37 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.35 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.34 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.35 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.35 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.37 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.34 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.33 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.34 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.32 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.3 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.25 linezolid
rplC 800889 c.81C>G synonymous_variant 0.16 linezolid
rplC 800892 c.84G>C synonymous_variant 0.19 linezolid
rplC 800904 c.96G>C synonymous_variant 0.23 linezolid
rplC 800907 c.99C>G synonymous_variant 0.24 linezolid
rplC 800916 c.108A>G synonymous_variant 0.24 linezolid
rplC 800922 c.114C>G synonymous_variant 0.24 linezolid
rplC 800928 c.120C>T synonymous_variant 0.22 linezolid
rplC 800931 c.123G>C synonymous_variant 0.22 linezolid
rplC 800937 c.129A>G synonymous_variant 0.24 linezolid
rplC 800943 c.135C>T synonymous_variant 0.25 linezolid
rplC 800946 c.138T>C synonymous_variant 0.24 linezolid
rplC 800949 c.141T>C synonymous_variant 0.26 linezolid
rplC 800970 c.162T>C synonymous_variant 0.29 linezolid Not assoc w R - Interim
rplC 800982 c.174C>T synonymous_variant 0.26 linezolid
rplC 800985 c.177A>C synonymous_variant 0.24 linezolid
rplC 801195 c.387G>C synonymous_variant 0.19 linezolid
rplC 801207 c.399C>T synonymous_variant 0.23 linezolid
rplC 801222 c.414T>C synonymous_variant 0.27 linezolid
rplC 801246 c.438C>G synonymous_variant 0.24 linezolid
rplC 801249 c.441T>G synonymous_variant 0.23 linezolid
rplC 801252 c.444G>C synonymous_variant 0.23 linezolid
rplC 801255 c.447C>T synonymous_variant 0.23 linezolid
rplC 801312 c.504G>C synonymous_variant 0.16 linezolid
rplC 801321 c.513C>T synonymous_variant 0.16 linezolid Not assoc w R - Interim
rplC 801367 p.Ala187Pro missense_variant 0.16 linezolid
rplC 801385 c.577C>T synonymous_variant 0.15 linezolid
fbiC 1303554 c.624G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303587 c.657G>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303755 c.825T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303768 p.Ser280Ala missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303789 p.Ile287Val missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303890 c.960G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303896 c.966G>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303897 c.967C>T synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303908 c.978C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304712 c.1782C>A synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304853 c.1923C>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304869 c.1939C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304922 c.1992C>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304995 c.2065T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305009 c.2079C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305096 c.2166T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305111 c.2181C>T synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305114 c.2184T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>C synonymous_variant 0.25 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305135 c.2205C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305150 c.2220C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305173 p.Asn748Ser missense_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305181 c.2251T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305195 c.2265T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305199 p.Ala757Ser missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305204 c.2274C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305210 c.2280G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305215 p.Ser762Thr missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305240 c.2310T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305243 c.2313T>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305244 c.2314T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305273 c.2343C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305279 p.His783Gln missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305297 c.2367G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305303 c.2373T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305311 p.Arg794Gln missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305318 c.2388C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305330 c.2400C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305332 p.Glu801Gly missense_variant 0.22 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1305348 c.2418C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305361 c.2431C>T synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305382 c.2452C>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305399 c.2469A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305417 c.2487C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305420 c.2490C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305423 c.2493T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
atpE 1460813 c.-232C>T upstream_gene_variant 0.21 bedaquiline
atpE 1460816 c.-229T>C upstream_gene_variant 0.2 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.2 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.24 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.19 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.19 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.2 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.2 bedaquiline
atpE 1461212 c.168C>G synonymous_variant 0.18 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.18 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.18 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.19 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.18 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473752 n.95G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473981 n.324_325insT non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.38 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474044 n.387C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474110 n.453A>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.634_649delTTTCCTCTCCGGAGGAinsC non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474969 n.1312G>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475400 n.1743C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid Uncertain significance
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476746 n.3089T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
inhA 1673547 c.-655T>C upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1673574 c.-628C>A upstream_gene_variant 0.17 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.17 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.18 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.18 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.15 ethionamide
isoniazid
inhA 1673904 c.-298C>A upstream_gene_variant 0.16 ethionamide
isoniazid
inhA 1673913 c.-289C>G upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1673916 c.-286A>C upstream_gene_variant 0.17 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.18 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.2 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.3 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.21 ethionamide
isoniazid
inhA 1674012 c.-190C>G upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674540 c.339C>T synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.18 ethionamide
isoniazid
inhA 1674561 c.360C>T synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674573 c.372G>T synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.18 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.18 ethionamide
isoniazid
inhA 1674618 c.417C>T synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674624 c.423A>T synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674639 c.438C>T synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674741 c.540C>T synonymous_variant 0.24 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674746 p.Tyr182Phe missense_variant 0.24 ethionamide
isoniazid
inhA 1674750 c.549T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.25 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674774 c.573A>G synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674790 c.589C>T synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674828 c.627G>A synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674840 c.639C>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.2 ethionamide
isoniazid
inhA 1674850 c.649C>T synonymous_variant 0.2 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674858 c.657G>A synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.36 ethionamide
isoniazid
inhA 1674909 c.708G>C synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674939 c.738G>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674960 c.759C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674966 c.765T>A synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674967 p.Asp256Thr missense_variant 0.16 ethionamide
isoniazid
rpsA 1833541 c.-1T>C upstream_gene_variant 0.17 pyrazinamide
rpsA 1833589 c.48A>T synonymous_variant 0.26 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.27 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833727 c.186G>T synonymous_variant 0.29 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1833793 c.252C>T synonymous_variant 0.28 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833844 c.303C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.31 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.3 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.4 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.21 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.18 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.23 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834213 c.672G>A synonymous_variant 0.33 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834534 c.993C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834618 c.1077G>T synonymous_variant 0.32 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.32 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.3 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834771 c.1230G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.17 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.28 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.25 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.24 linezolid
tsnR 1853394 c.-212_-210delCTCinsGCG upstream_gene_variant 0.21 linezolid
tsnR 1853418 c.-188_-186delCTTinsTG upstream_gene_variant 0.24 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.22 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.21 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917981 c.42G>C synonymous_variant 0.21 capreomycin
tlyA 1917990 c.51G>C synonymous_variant 0.22 capreomycin
tlyA 1917993 c.54A>G synonymous_variant 0.21 capreomycin Not assoc w R - Interim
tlyA 1918002 c.63A>G synonymous_variant 0.24 capreomycin
tlyA 1918026 c.87C>G synonymous_variant 0.22 capreomycin
tlyA 1918029 c.90C>G synonymous_variant 0.22 capreomycin
tlyA 1918036 p.Arg33Ser missense_variant 0.21 capreomycin
tlyA 1918048 p.Leu37Met missense_variant 0.16 capreomycin
ndh 2102227 c.816C>G synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2102233 c.810G>A synonymous_variant 0.16 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2102247 p.Val266Ile missense_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2102269 c.774C>G synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102296 c.747C>G synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2102674 c.369G>A synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2102680 c.363T>G synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102683 c.360T>C synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102686 c.357G>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102694 p.Val117Ile missense_variant 0.18 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
katG 2155637 p.Leu159Ile missense_variant 0.17 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.2 isoniazid Uncertain significance
katG 2155676 c.436C>A synonymous_variant 0.22 isoniazid
katG 2155686 c.426C>T synonymous_variant 0.22 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.26 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.26 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.26 isoniazid
katG 2155722 c.390G>T synonymous_variant 0.24 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.21 isoniazid
katG 2155766 p.His116Tyr missense_variant 0.16 isoniazid Uncertain significance
katG 2155785 c.327T>C synonymous_variant 0.17 isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289967 c.-726C>G upstream_gene_variant 0.21 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.22 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.22 pyrazinamide
pncA 2290006 c.-765T>C upstream_gene_variant 0.21 pyrazinamide
pncA 2290009 c.-768A>G upstream_gene_variant 0.22 pyrazinamide
pncA 2290015 c.-774A>C upstream_gene_variant 0.21 pyrazinamide
pncA 2290021 c.-780C>G upstream_gene_variant 0.2 pyrazinamide
pncA 2290024 c.-783C>G upstream_gene_variant 0.18 pyrazinamide
pncA 2290032 c.-791A>C upstream_gene_variant 0.17 pyrazinamide
pncA 2290033 c.-792C>G upstream_gene_variant 0.17 pyrazinamide
pncA 2290042 c.-801T>C upstream_gene_variant 0.17 pyrazinamide
kasA 2517974 c.-141T>C upstream_gene_variant 0.24 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.17 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.17 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.17 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.25 isoniazid
kasA 2518183 c.69G>A synonymous_variant 0.25 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.27 isoniazid
kasA 2518193 p.Pro27Ser missense_variant 0.27 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.23 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.18 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.16 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.24 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.26 isoniazid
kasA 2518537 c.423C>G synonymous_variant 0.26 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.3 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.3 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.31 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.3 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.31 isoniazid
kasA 2518585 c.471G>A synonymous_variant 0.23 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.22 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.22 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.2 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.18 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.18 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.21 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.21 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.23 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.23 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.26 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.26 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.3 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.33 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.31 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.33 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.31 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.29 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.29 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.28 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.21 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.21 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.17 isoniazid
folC 2747264 p.Gly112Ser missense_variant 0.18 para-aminosalicylic_acid
folC 2747274 p.Ser109Ala missense_variant 0.19 para-aminosalicylic_acid
folC 2747275 c.324T>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747284 c.315G>C synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.2 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747302 c.297A>C synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747305 c.294C>T synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.19 para-aminosalicylic_acid
folC 2747745 c.-147A>C upstream_gene_variant 0.16 para-aminosalicylic_acid
folC 2747752 c.-154G>C upstream_gene_variant 0.16 para-aminosalicylic_acid
folC 2747781 c.-183G>A upstream_gene_variant 0.18 para-aminosalicylic_acid
folC 2747790 c.-192G>C upstream_gene_variant 0.16 para-aminosalicylic_acid
folC 2747793 c.-195C>T upstream_gene_variant 0.16 para-aminosalicylic_acid
Rv2477c 2782450 c.1593C>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 c.1590C>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782515 c.1528C>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782522 c.1521G>A synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782546 c.1497C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782928 p.Thr372Lys missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Not assoc w R
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Not assoc w R
amikacin Uncertain significance
Rv2477c 2782948 c.1095A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.3 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783244 p.Thr267Ala missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783488 c.555G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783695 c.348C>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783770 c.273G>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783788 c.255T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783875 c.168G>A synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>A synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783967 c.76T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783968 c.75G>A synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784501 c.-459T>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859708 c.711C>T synonymous_variant 0.16 clofazimine
bedaquiline
pepQ 2859723 c.696T>C synonymous_variant 0.17 clofazimine Not assoc w R - Interim
bedaquiline
pepQ 2859739 p.Ala227Gly missense_variant 0.18 clofazimine
bedaquiline
pepQ 2859747 c.672C>G synonymous_variant 0.21 clofazimine
bedaquiline
pepQ 2859765 c.654G>C synonymous_variant 0.23 clofazimine
bedaquiline
pepQ 2859792 c.627C>T synonymous_variant 0.23 clofazimine
bedaquiline
pepQ 2859798 c.621G>C synonymous_variant 0.23 clofazimine
bedaquiline
pepQ 2859801 c.618G>C synonymous_variant 0.22 clofazimine
bedaquiline
pepQ 2859804 c.615C>T synonymous_variant 0.25 clofazimine
bedaquiline
pepQ 2859828 c.591G>C synonymous_variant 0.27 clofazimine
bedaquiline
pepQ 2859834 c.585T>C synonymous_variant 0.32 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
pepQ 2859843 c.576G>C synonymous_variant 0.3 clofazimine
bedaquiline
pepQ 2859852 c.567A>G synonymous_variant 0.26 clofazimine
bedaquiline
pepQ 2859864 c.555T>C synonymous_variant 0.32 clofazimine
bedaquiline
pepQ 2859870 c.549T>C synonymous_variant 0.31 clofazimine
bedaquiline
pepQ 2859873 c.546T>C synonymous_variant 0.33 clofazimine
bedaquiline
pepQ 2859903 c.516G>C synonymous_variant 0.26 clofazimine
bedaquiline
pepQ 2859908 p.Gln171Glu missense_variant 0.26 clofazimine
bedaquiline
pepQ 2859909 c.510G>C synonymous_variant 0.25 clofazimine
bedaquiline
pepQ 2859918 c.501A>G synonymous_variant 0.22 clofazimine
bedaquiline
pepQ 2859924 c.495G>C synonymous_variant 0.21 clofazimine
bedaquiline
pepQ 2859939 c.480C>T synonymous_variant 0.21 clofazimine
bedaquiline
pepQ 2859942 c.477C>G synonymous_variant 0.19 clofazimine
bedaquiline
Rv2752c 3064779 c.1413C>G synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064790 c.1402T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064791 c.1401T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064803 c.1389C>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064809 c.1383C>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064815 c.1377T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064818 c.1374C>T synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064831 p.Ala454Asn missense_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064838 c.1354T>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065946 p.Gly82Ala missense_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065955 c.235_237delTTGinsCC frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065979 c.213T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>G synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066071 c.121T>C synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066083 c.109C>T synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066084 c.108C>T synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066117 c.75C>T synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066734 c.-543G>A upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066741 c.-550T>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066747 c.-558_-556delCAAinsATC upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066756 c.-567_-565delCGGinsAC upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066762 c.-571G>C upstream_gene_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066780 c.-589C>G upstream_gene_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066801 c.-610C>T upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066804 c.-613G>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067229 c.717C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067249 p.Thr233Ser missense_variant 0.22 para-aminosalicylic_acid
thyX 3067250 c.694_696delGTGinsAC frameshift_variant&missense_variant 0.22 para-aminosalicylic_acid
thyX 3067277 c.669C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067284 p.Ala221Gly missense_variant 0.33 para-aminosalicylic_acid
thyX 3067286 c.658_660delGCCinsTG frameshift_variant&missense_variant 0.31 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067355 c.591A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067427 c.519G>C synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.28 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067470 p.Asn159Ser missense_variant 0.27 para-aminosalicylic_acid
thyX 3067478 c.468C>T synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067499 c.447G>A synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067504 p.Ala148Thr missense_variant 0.2 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067643 c.303C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067646 c.300C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067658 c.288C>T synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067727 c.219A>T synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067742 c.204A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.2 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.2 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067861 p.Ala29Thr missense_variant 0.28 para-aminosalicylic_acid
thyX 3067869 p.Thr26Asp missense_variant 0.3 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067935 p.Thr4Ile missense_variant 0.17 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073866 c.604_606delACCinsGG frameshift_variant&missense_variant 0.25 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.25 para-aminosalicylic_acid
thyA 3073887 c.583_585delTCGinsGC frameshift_variant&missense_variant 0.28 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073953 c.519T>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073958 c.514C>T synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.22 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.21 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074120 c.352T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074121 c.351T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074154 c.318T>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074160 c.312A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAG frameshift_variant&missense_variant 0.2 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074184 c.288A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.27 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074217 c.255T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074244 c.228A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074252 p.Glu74Gln missense_variant 0.21 para-aminosalicylic_acid
thyA 3074263 p.Gly70Asp missense_variant 0.17 para-aminosalicylic_acid
thyA 3074267 p.Ile69Val missense_variant 0.16 para-aminosalicylic_acid
thyA 3074268 c.204T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074274 c.198T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074372 p.Met34Leu missense_variant 0.16 para-aminosalicylic_acid
thyA 3074379 c.93C>T synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0 pyrazinamide Not assoc w R
Rv3236c 3612643 c.474A>G synonymous_variant 0.19 pyrazinamide
Rv3236c 3612667 c.450T>C synonymous_variant 0.23 pyrazinamide
Rv3236c 3612676 c.441A>G synonymous_variant 0.23 pyrazinamide
Rv3236c 3612694 p.Arg141His missense_variant 0.22 pyrazinamide Uncertain significance
lpqB 3623484 p.Phe476Tyr missense_variant 0.18 bedaquiline
rifampicin
lpqB 3624071 c.840C>T synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624080 p.Arg277Ser missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.15 bedaquiline
rifampicin
lpqB 3624131 c.778_780delAGGinsCC frameshift_variant&missense_variant 0.17 bedaquiline
rifampicin Uncertain significance
lpqB 3624158 c.753G>A synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624365 c.546T>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624371 c.540T>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624377 c.534C>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624389 c.522C>G synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625282 c.-372C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625313 p.Arg434Lys missense_variant 0.16 bedaquiline
rifampicin
mtrB 3625572 p.Thr348Ser missense_variant 0.17 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.23 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.27 bedaquiline
rifampicin
lpqB 3625630 c.-720C>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625654 c.958_960delTTGinsCC frameshift_variant&missense_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625663 c.-753G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625675 c.-765G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.3 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.29 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625798 c.-888G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625803 c.-893C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625813 c.801C>T synonymous_variant 0.29 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625852 c.762A>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625855 c.759G>A synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625864 c.750T>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625876 c.738G>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625888 c.726G>A synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCT frameshift_variant&missense_variant 0.21 bedaquiline
rifampicin
mtrB 3626777 c.-164C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626867 c.-254G>A upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3626885 c.-272A>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626900 c.-287G>A upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3626975 c.-362C>T upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626999 c.-386G>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3627016 c.-403C>T upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.49 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627116 c.-503G>A upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.26 bedaquiline
rifampicin
mtrB 3627209 c.-596G>A upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
fbiB 3642656 c.1122G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
alr 3840719 c.702A>G synonymous_variant 1.0 cycloserine
alr 3840994 p.His143Asp missense_variant 0.19 cycloserine
alr 3840997 c.424T>C synonymous_variant 0.18 cycloserine
alr 3841001 c.420A>G synonymous_variant 0.18 cycloserine
alr 3841010 c.411A>G synonymous_variant 0.2 cycloserine
alr 3841017 p.Leu135Glu missense_variant 0.2 cycloserine
alr 3841022 c.399C>G synonymous_variant 0.19 cycloserine
alr 3841028 c.393G>C synonymous_variant 0.19 cycloserine
alr 3841033 p.Val130Ile missense_variant 0.19 cycloserine
rpoA 3877553 p.Glu319Gln missense_variant 0.3 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 0.27 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.28 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.25 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.24 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877788 c.720G>A synonymous_variant 0.3 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.26 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.29 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.32 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.31 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.29 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.27 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.31 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.17 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.18 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.19 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.18 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.18 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.19 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.17 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.21 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.22 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.27 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.3 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.3 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.28 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.37 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.32 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.22 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.21 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.26 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.24 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.25 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.28 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.26 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.27 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.27 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.26 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.29 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.25 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.22 rifampicin
rpoA 3878458 p.Asn17Ser missense_variant 0.19 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.16 rifampicin
rpoA 3878483 c.25C>T synonymous_variant 0.16 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.16 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.17 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.17 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.23 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.24 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.23 rifampicin
rpoA 3878839 c.-332C>G upstream_gene_variant 0.23 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.36 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878890 c.-383C>G upstream_gene_variant 0.25 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.24 rifampicin
rpoA 3878917 c.-410G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878935 c.-428C>T upstream_gene_variant 0.21 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.19 rifampicin
rpoA 3879050 c.-543A>C upstream_gene_variant 0.19 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.22 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.29 rifampicin
rpoA 3879082 c.-575C>G upstream_gene_variant 0.29 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.34 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.34 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.37 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.39 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.38 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.35 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.28 rifampicin
rpoA 3879202 c.-695T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879208 c.-701C>G upstream_gene_variant 0.23 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.38 delamanid
pretomanid
ddn 3986645 c.-199G>A upstream_gene_variant 0.37 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.36 delamanid
pretomanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.28 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.28 delamanid
pretomanid
ddn 3986693 c.-151C>T upstream_gene_variant 0.26 delamanid
pretomanid
ddn 3986696 c.-148G>T upstream_gene_variant 0.22 delamanid
pretomanid
clpC1 4038239 c.2466T>G synonymous_variant 0.19 pyrazinamide
clpC1 4038255 p.Val817Lys missense_variant 0.18 pyrazinamide
clpC1 4038257 c.2448G>A synonymous_variant 0.19 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.21 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.2 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038287 c.2416_2418delAACinsGT frameshift_variant&missense_variant 0.78 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038308 c.2397G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.29 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.31 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038374 c.2331C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.21 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038486 p.Gly740Thr missense_variant 0.21 pyrazinamide
clpC1 4038488 c.2217C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038498 p.Ser736Asn missense_variant 0.24 pyrazinamide
clpC1 4038519 p.Arg729Lys missense_variant 0.25 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.25 pyrazinamide
clpC1 4038533 p.Arg724Lys missense_variant 0.26 pyrazinamide
clpC1 4038575 c.2130C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.32 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.26 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.24 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038674 c.2031C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038693 p.Ser671Gly missense_variant 0.26 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.27 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.3 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.29 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.37 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.41 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039328 p.Ala459Gly missense_variant 0.17 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.17 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039361 c.1344C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.3 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.26 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039480 c.1225C>A synonymous_variant 0.24 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.34 pyrazinamide
clpC1 4039487 c.1218G>T synonymous_variant 0.23 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039520 c.1185G>A synonymous_variant 0.32 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.36 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039631 c.1074C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.37 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.34 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.32 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.34 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.29 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.35 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040168 c.537G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.23 pyrazinamide
clpC1 4040222 c.483G>A synonymous_variant 0.21 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.22 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040258 c.447G>A synonymous_variant 0.32 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.24 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040324 c.381G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040462 c.243C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.22 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040567 c.138C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040582 c.123G>T synonymous_variant 0.18 pyrazinamide
panD 4044120 c.162A>G synonymous_variant 0.21 pyrazinamide
panD 4044123 c.159T>C synonymous_variant 0.2 pyrazinamide
panD 4044126 c.156T>C synonymous_variant 0.2 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>G synonymous_variant 0.21 pyrazinamide
panD 4044162 c.120A>G synonymous_variant 0.18 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.18 pyrazinamide
panD 4044174 c.108C>G synonymous_variant 0.2 pyrazinamide
panD 4044189 c.93C>T synonymous_variant 0.19 pyrazinamide
panD 4044237 c.45G>C synonymous_variant 0.18 pyrazinamide
panD 4044240 c.42G>C synonymous_variant 0.17 pyrazinamide
panD 4044246 c.36C>G synonymous_variant 0.18 pyrazinamide
panD 4044264 c.18G>C synonymous_variant 0.17 pyrazinamide
panD 4044764 c.-483C>A upstream_gene_variant 0.21 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.21 pyrazinamide
panD 4044785 c.-504C>G upstream_gene_variant 0.21 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.22 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.21 pyrazinamide
panD 4044818 c.-537G>C upstream_gene_variant 0.17 pyrazinamide
panD 4044848 c.-567T>A upstream_gene_variant 0.15 pyrazinamide
glpK 4138406 c.1350G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138412 c.1344G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138418 c.1338T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138424 c.1332T>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138429 c.1327T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138433 c.1323C>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138442 c.1314C>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138451 c.1305T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138454 c.1302G>A synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138478 c.1278T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138481 c.1275G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138490 c.1266G>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138495 p.Gln421Glu missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138496 c.1260G>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138502 c.1254T>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138514 c.1242A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138517 p.Glu413Ala missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138541 c.1215C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138580 c.1176C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138616 c.1140G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138654 c.1102C>T synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138769 c.987G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138775 c.981C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138781 c.975G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138817 c.939T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138822 p.Asn312Asp missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139135 c.619_621delGATinsAC frameshift_variant&synonymous_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139174 p.Val194Ala missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139177 c.579T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139183 c.573T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139186 c.570G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139189 c.567G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139198 c.558C>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139206 c.550C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139552 c.202_204delGCGinsTC frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139573 c.183C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139581 p.Asn59Asp missense_variant 0.29 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139594 c.162C>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139600 c.156G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139627 c.129G>A synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139630 c.126C>T synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139651 c.103_105delCACinsGG frameshift_variant&missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139657 c.99T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139675 c.81C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240543 c.681G>C synonymous_variant 0.24 ethambutol
embC 4240561 c.699C>G synonymous_variant 0.17 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.2 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.18 ethambutol
embC 4240685 c.823_825delACCinsGG frameshift_variant&missense_variant 0.2 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.22 ethambutol
embC 4240698 p.Ala279Gly missense_variant 0.23 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4240735 c.873C>G synonymous_variant 0.25 ethambutol
embC 4240766 c.904C>A synonymous_variant 0.36 ethambutol
embC 4240771 c.909G>C synonymous_variant 0.35 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.35 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.36 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.4 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.35 ethambutol
embC 4240825 c.963G>A synonymous_variant 0.33 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.33 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.25 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.21 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.19 ethambutol
embC 4241023 c.1161T>C synonymous_variant 0.25 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.3 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.34 ethambutol
embC 4241056 c.1194C>G synonymous_variant 0.35 ethambutol
embC 4241101 c.1239G>A synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embC 4241104 c.1242G>A synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>A synonymous_variant 0.27 ethambutol
embC 4241110 c.1248G>C synonymous_variant 0.26 ethambutol
embC 4241129 c.1267C>T synonymous_variant 0.24 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241158 c.1296T>C synonymous_variant 0.22 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.21 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.19 ethambutol
embC 4241206 c.1344G>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241725 c.1863G>C synonymous_variant 0.17 ethambutol
embC 4241727 p.Phe622Tyr missense_variant 0.17 ethambutol
embC 4241741 c.1879_1881delGTCinsTG frameshift_variant&missense_variant 0.16 ethambutol
embC 4241747 p.Val629Leu missense_variant 0.17 ethambutol
embC 4241750 p.Leu630Val missense_variant 0.18 ethambutol
embC 4241755 c.1893C>G synonymous_variant 0.18 ethambutol
embC 4241756 c.1894C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241794 c.1932C>G synonymous_variant 0.16 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245074 c.1842G>T synonymous_variant 0.18 ethambutol
embA 4245078 p.Trp616Val missense_variant 0.18 ethambutol
embA 4245083 c.1851A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embA 4245089 c.1857G>C synonymous_variant 0.22 ethambutol
embA 4245101 c.1869G>A synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embA 4245137 c.1905T>C synonymous_variant 0.24 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.28 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.26 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.26 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.26 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.25 ethambutol
embA 4245198 p.Leu656Ala missense_variant 0.19 ethambutol
embA 4245206 c.1974A>C synonymous_variant 0.19 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.2 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.23 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.25 ethambutol Uncertain significance
embA 4245248 c.2016G>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247380 c.867C>G synonymous_variant 0.16 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.21 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.2 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.25 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.28 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.29 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.37 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.36 ethambutol
embB 4247476 c.963C>T synonymous_variant 0.38 ethambutol
embB 4247485 c.972C>T synonymous_variant 0.36 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.35 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.3 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.31 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.33 ethambutol
embB 4247544 p.Ser344Thr missense_variant 0.33 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.32 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.22 ethambutol
embB 4247567 c.1054_1056delCTGinsTA frameshift_variant&stop_gained 0.22 ethambutol
embB 4247572 c.1059A>C synonymous_variant 0.2 ethambutol
embB 4247579 p.Ala356Ile missense_variant 0.22 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.21 ethambutol
embB 4247785 c.1272G>C synonymous_variant 0.17 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.18 ethambutol
embB 4247806 c.1293G>C synonymous_variant 0.17 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.24 ethambutol
embB 4247830 c.1317A>C synonymous_variant 0.23 ethambutol
embB 4247836 c.1323A>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247842 c.1329T>C synonymous_variant 0.21 ethambutol
embB 4247845 c.1332G>C synonymous_variant 0.22 ethambutol
embB 4247851 c.1338C>A synonymous_variant 0.21 ethambutol
embB 4247857 c.1344C>G synonymous_variant 0.21 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.17 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.2 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.26 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.25 ethambutol Uncertain significance
embB 4248044 p.Lys511Ser missense_variant 0.24 ethambutol
embB 4248052 c.1539G>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4248055 c.1542G>C synonymous_variant 0.25 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.26 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.25 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.3 ethambutol
embB 4248118 c.1605T>G synonymous_variant 0.27 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.26 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.24 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.24 ethambutol
embB 4248146 c.1633_1635delATCinsGA frameshift_variant&missense_variant 0.24 ethambutol
embB 4248149 p.Thr546Ala missense_variant 0.24 ethambutol Uncertain significance
embB 4248157 c.1644A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4248175 c.1662G>C synonymous_variant 0.33 ethambutol
embB 4248178 c.1665C>T synonymous_variant 0.35 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.34 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.32 ethambutol Uncertain significance
embB 4248211 c.1698G>C synonymous_variant 0.29 ethambutol
embB 4248214 c.1701C>A synonymous_variant 0.28 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4248223 c.1710G>C synonymous_variant 0.27 ethambutol
embB 4248226 c.1713G>C synonymous_variant 0.27 ethambutol
embB 4248241 c.1728C>T synonymous_variant 0.37 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.35 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.29 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.29 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.24 ethambutol
aftB 4269006 c.-170T>C upstream_gene_variant 0.17 ethambutol
aftB 4269018 c.-182G>T upstream_gene_variant 0.16 ethambutol
aftB 4269027 c.-191C>G upstream_gene_variant 0.17 ethambutol
aftB 4269033 c.-197T>C upstream_gene_variant 0.17 ethambutol
aftB 4269036 c.-200C>G upstream_gene_variant 0.19 ethambutol
aftB 4269042 c.-206G>C upstream_gene_variant 0.24 ethambutol
ubiA 4269075 c.757_759delATTinsGG frameshift_variant&missense_variant 0.2 ethambutol
ubiA 4269080 p.Met252Leu missense_variant 0.2 ethambutol
ubiA 4269091 p.Phe248Tyr missense_variant 0.18 ethambutol
aftB 4269123 c.-287T>G upstream_gene_variant 0.22 ethambutol
aftB 4269132 c.-296G>C upstream_gene_variant 0.22 ethambutol
aftB 4269156 c.-320C>G upstream_gene_variant 0.18 ethambutol
ubiA 4269164 p.Leu224Met missense_variant 0.2 ethambutol
ubiA 4269177 c.657G>A synonymous_variant 0.29 ethambutol Not assoc w R - Interim
aftB 4269201 c.-365A>G upstream_gene_variant 0.28 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.19 ethambutol
ubiA 4269222 c.612T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
aftB 4269234 c.-398A>G upstream_gene_variant 0.18 ethambutol
aftB 4269240 c.-404G>C upstream_gene_variant 0.17 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R