TB-Profiler

TB-Profiler result

Run: SRR25827682

Summary

Run ID: SRR25827682

Sample name:

Date: 2024-05-22T16:45:40.604251

Number of reads: 2223225

Percentage reads mapped: 52.23

Median coverage: 52.0

Strain:

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs

Lineage	Family	RDs	Frequency
La1.7.1	M.bovis	None	0.07

Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol	embB	p.His312Arg		Mutation from literature
ethambutol	embB	p.Tyr384Asn		Mutation from literature
p.Ala388Gly		Mutation from literature
p.Asn399Asp		Mutation from literature
pyrazinamide
streptomycin	rrs	n.462C>T	Uncertain significance	Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid	fgd1	c.412_414delCTAinsTG	Assoc w R - Interim	Confers DLM-PMD cross-resistance
delamanid	fbiC	c.859_861delATCinsGG	Assoc w R - Interim	Confers DLM-PMD cross-resistance
c.2224_2226delTTGinsCA	fbiC	Assoc w R - Interim	Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC	Assoc w R - Interim	Confers DLM-PMD cross-resistance
bedaquiline
linezolid

Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
fgd1	491194	c.412_414delCTAinsTG	frameshift_variant&stop_gained	0.4	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fgd1	491194	c.412_414delCTAinsTG	frameshift_variant&stop_gained	0.4	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303789	c.859_861delATCinsGG	frameshift_variant&missense_variant	0.73	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1303789	c.859_861delATCinsGG	frameshift_variant&missense_variant	0.73	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1305154	c.2224_2226delTTGinsCA	frameshift_variant&missense_variant	0.29	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1305154	c.2224_2226delTTGinsCA	frameshift_variant&missense_variant	0.29	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1305331	c.2401_2403delGAAinsAC	frameshift_variant&missense_variant	0.59	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
fbiC	1305331	c.2401_2403delGAAinsAC	frameshift_variant&missense_variant	0.59	delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
rrs	1472307	n.462C>T	non_coding_transcript_exon_variant	0.81	streptomycin	Uncertain significance	Mutation from literature
embB	4247448	p.His312Arg	missense_variant	0.76	ethambutol		Mutation from literature
embB	4247663	p.Tyr384Asn	missense_variant	0.46	ethambutol		Mutation from literature
embB	4247676	p.Ala388Gly	missense_variant	0.55	ethambutol		Mutation from literature
embB	4247708	p.Asn399Asp	missense_variant	0.6	ethambutol		Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	1014	c.1014C>G	synonymous_variant	0.28	isoniazid
dnaA	1024	c.1024T>C	synonymous_variant	0.26	isoniazid
dnaA	1038	c.1038A>T	synonymous_variant	0.35	isoniazid
dnaA	1041	c.1041G>A	synonymous_variant	0.41	isoniazid
dnaA	1047	c.1047A>G	synonymous_variant	0.43	isoniazid
dnaA	1068	c.1068T>C	synonymous_variant	0.49	isoniazid
dnaA	1092	c.1092T>C	synonymous_variant	0.47	isoniazid	Not assoc w R - Interim
dnaA	1098	c.1098A>G	synonymous_variant	0.46	isoniazid
dnaA	1104	c.1104T>C	synonymous_variant	0.46	isoniazid
dnaA	1110	c.1110T>C	synonymous_variant	0.46	isoniazid
dnaA	1113	c.1113A>G	synonymous_variant	0.46	isoniazid
dnaA	1125	c.1125G>C	synonymous_variant	0.45	isoniazid
dnaA	1137	c.1137C>G	synonymous_variant	0.45	isoniazid
dnaA	1143	c.1143G>C	synonymous_variant	0.46	isoniazid
dnaA	1152	c.1152A>G	synonymous_variant	0.42	isoniazid
dnaA	1153	c.1153T>C	synonymous_variant	0.41	isoniazid
dnaA	1161	c.1161A>G	synonymous_variant	0.38	isoniazid
dnaA	1164	c.1164A>C	synonymous_variant	0.38	isoniazid
dnaA	1167	c.1167A>G	synonymous_variant	0.38	isoniazid	Not assoc w R - Interim
dnaA	1176	c.1176A>G	synonymous_variant	0.38	isoniazid
dnaA	1188	c.1188G>A	synonymous_variant	0.32	isoniazid
dnaA	1191	c.1191T>C	synonymous_variant	0.26	isoniazid
dnaA	1197	c.1197T>C	synonymous_variant	0.24	isoniazid	Not assoc w R - Interim
gyrA	6700	c.-602T>C	upstream_gene_variant	0.41	levofloxacin
gyrA	6700	c.-602T>C	upstream_gene_variant	0.41	moxifloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	0.41	levofloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	0.41	moxifloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	0.41	levofloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	0.41	moxifloxacin
gyrA	6712	c.-590G>C	upstream_gene_variant	0.42	levofloxacin
gyrA	6712	c.-590G>C	upstream_gene_variant	0.42	moxifloxacin
gyrB	6728	c.1489_1491delCTAinsTG	frameshift_variant&stop_gained	0.42	levofloxacin	Uncertain significance
gyrB	6728	c.1489_1491delCTAinsTG	frameshift_variant&stop_gained	0.42	moxifloxacin
gyrA	6742	c.-560A>G	upstream_gene_variant	0.41	levofloxacin
gyrA	6742	c.-560A>G	upstream_gene_variant	0.41	moxifloxacin
gyrB	6745	c.1506T>G	synonymous_variant	0.41	levofloxacin	Not assoc w R - Interim
gyrB	6745	c.1506T>G	synonymous_variant	0.41	moxifloxacin	Not assoc w R - Interim
gyrA	6751	c.-551G>C	upstream_gene_variant	0.4	levofloxacin
gyrA	6751	c.-551G>C	upstream_gene_variant	0.4	moxifloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	0.41	levofloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	0.41	moxifloxacin
gyrB	6763	c.1524G>C	synonymous_variant	0.42	levofloxacin	Not assoc w R - Interim
gyrB	6763	c.1524G>C	synonymous_variant	0.42	moxifloxacin	Not assoc w R - Interim
gyrB	6775	c.1536G>C	synonymous_variant	0.41	levofloxacin	Not assoc w R - Interim
gyrB	6775	c.1536G>C	synonymous_variant	0.41	moxifloxacin	Not assoc w R - Interim
gyrB	6793	c.1554T>C	synonymous_variant	0.34	levofloxacin	Not assoc w R - Interim
gyrB	6793	c.1554T>C	synonymous_variant	0.34	moxifloxacin	Not assoc w R - Interim
gyrB	6797	p.Gly520Thr	missense_variant	0.36	levofloxacin
gyrB	6797	p.Gly520Thr	missense_variant	0.36	moxifloxacin
gyrB	6811	c.1572C>T	synonymous_variant	0.32	levofloxacin
gyrB	6811	c.1572C>T	synonymous_variant	0.32	moxifloxacin	Not assoc w R - Interim
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	8198	c.897T>C	synonymous_variant	0.26	levofloxacin	Not assoc w R - Interim
gyrA	8198	c.897T>C	synonymous_variant	0.26	moxifloxacin	Not assoc w R - Interim
gyrA	8207	c.906T>C	synonymous_variant	0.28	levofloxacin
gyrA	8207	c.906T>C	synonymous_variant	0.28	moxifloxacin
gyrA	8219	c.918T>C	synonymous_variant	0.27	levofloxacin	Not assoc w R - Interim
gyrA	8219	c.918T>C	synonymous_variant	0.27	moxifloxacin	Not assoc w R - Interim
gyrA	8225	c.924T>C	synonymous_variant	0.27	levofloxacin
gyrA	8225	c.924T>C	synonymous_variant	0.27	moxifloxacin
gyrA	8234	c.933T>C	synonymous_variant	0.27	levofloxacin
gyrA	8234	c.933T>C	synonymous_variant	0.27	moxifloxacin
gyrA	8237	c.936A>G	synonymous_variant	0.28	levofloxacin
gyrA	8237	c.936A>G	synonymous_variant	0.28	moxifloxacin
gyrA	9089	c.1788G>C	synonymous_variant	0.4	levofloxacin
gyrA	9089	c.1788G>C	synonymous_variant	0.4	moxifloxacin
gyrA	9099	c.1798_1800delTTAinsCG	frameshift_variant&missense_variant	0.44	levofloxacin
gyrA	9099	c.1798_1800delTTAinsCG	frameshift_variant&missense_variant	0.44	moxifloxacin
gyrA	9104	c.1803C>G	synonymous_variant	0.44	levofloxacin	Not assoc w R - Interim
gyrA	9104	c.1803C>G	synonymous_variant	0.44	moxifloxacin	Not assoc w R - Interim
gyrA	9119	c.1818A>G	synonymous_variant	0.49	levofloxacin
gyrA	9119	c.1818A>G	synonymous_variant	0.49	moxifloxacin
gyrA	9122	c.1821C>G	synonymous_variant	0.52	levofloxacin	Not assoc w R - Interim
gyrA	9122	c.1821C>G	synonymous_variant	0.52	moxifloxacin	Not assoc w R - Interim
gyrA	9143	c.1842T>C	synonymous_variant	0.56	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	0.56	moxifloxacin	Not assoc w R
gyrA	9152	c.1851C>T	synonymous_variant	0.54	levofloxacin	Not assoc w R - Interim
gyrA	9152	c.1851C>T	synonymous_variant	0.54	moxifloxacin	Not assoc w R - Interim
gyrA	9153	p.Thr618Glu	missense_variant	0.55	levofloxacin
gyrA	9153	p.Thr618Glu	missense_variant	0.55	moxifloxacin
gyrA	9158	c.1857C>T	synonymous_variant	0.55	levofloxacin	Not assoc w R - Interim
gyrA	9158	c.1857C>T	synonymous_variant	0.55	moxifloxacin	Not assoc w R - Interim
gyrA	9161	c.1860C>G	synonymous_variant	0.55	levofloxacin
gyrA	9161	c.1860C>G	synonymous_variant	0.55	moxifloxacin
gyrA	9182	c.1881T>C	synonymous_variant	0.61	levofloxacin	Not assoc w R - Interim
gyrA	9182	c.1881T>C	synonymous_variant	0.61	moxifloxacin	Not assoc w R - Interim
gyrA	9191	c.1890G>C	synonymous_variant	0.66	levofloxacin
gyrA	9191	c.1890G>C	synonymous_variant	0.66	moxifloxacin
gyrA	9200	c.1899A>G	synonymous_variant	0.68	levofloxacin	Not assoc w R - Interim
gyrA	9200	c.1899A>G	synonymous_variant	0.68	moxifloxacin	Not assoc w R - Interim
gyrA	9204	p.Ser635Thr	missense_variant	0.7	levofloxacin
gyrA	9204	p.Ser635Thr	missense_variant	0.7	moxifloxacin
gyrA	9224	c.1923C>T	synonymous_variant	0.73	levofloxacin
gyrA	9224	c.1923C>T	synonymous_variant	0.73	moxifloxacin
gyrA	9230	c.1929T>C	synonymous_variant	0.73	levofloxacin
gyrA	9230	c.1929T>C	synonymous_variant	0.73	moxifloxacin
gyrA	9233	c.1932C>G	synonymous_variant	0.72	levofloxacin
gyrA	9233	c.1932C>G	synonymous_variant	0.72	moxifloxacin
gyrA	9239	c.1938C>T	synonymous_variant	0.72	levofloxacin	Not assoc w R - Interim
gyrA	9239	c.1938C>T	synonymous_variant	0.72	moxifloxacin	Not assoc w R - Interim
gyrA	9252	p.Val651Ile	missense_variant	0.67	levofloxacin	Uncertain significance
gyrA	9252	p.Val651Ile	missense_variant	0.67	moxifloxacin	Uncertain significance
gyrA	9278	c.1977G>T	synonymous_variant	0.7	levofloxacin
gyrA	9278	c.1977G>T	synonymous_variant	0.7	moxifloxacin
gyrA	9284	c.1983T>C	synonymous_variant	0.72	levofloxacin
gyrA	9284	c.1983T>C	synonymous_variant	0.72	moxifloxacin
gyrA	9291	c.1990C>T	synonymous_variant	0.72	levofloxacin
gyrA	9291	c.1990C>T	synonymous_variant	0.72	moxifloxacin
gyrA	9296	c.1995T>C	synonymous_variant	0.72	levofloxacin	Not assoc w R - Interim
gyrA	9296	c.1995T>C	synonymous_variant	0.72	moxifloxacin	Not assoc w R - Interim
gyrA	9299	c.1998G>C	synonymous_variant	0.73	levofloxacin	Not assoc w R - Interim
gyrA	9299	c.1998G>C	synonymous_variant	0.73	moxifloxacin	Not assoc w R - Interim
gyrA	9300	p.Ala667Ser	missense_variant	0.73	levofloxacin
gyrA	9300	p.Ala667Ser	missense_variant	0.73	moxifloxacin
gyrA	9304	p.Gly668Asp	missense_variant	0.74	levofloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	0.74	moxifloxacin	Not assoc w R
gyrA	9308	p.Asp669Glu	missense_variant	0.73	levofloxacin
gyrA	9308	p.Asp669Glu	missense_variant	0.73	moxifloxacin
gyrA	9323	c.2022C>G	synonymous_variant	0.73	levofloxacin	Not assoc w R - Interim
gyrA	9323	c.2022C>G	synonymous_variant	0.73	moxifloxacin	Not assoc w R - Interim
gyrA	9335	c.2034G>C	synonymous_variant	0.73	levofloxacin
gyrA	9335	c.2034G>C	synonymous_variant	0.73	moxifloxacin
gyrA	9365	c.2064G>A	synonymous_variant	0.63	levofloxacin
gyrA	9365	c.2064G>A	synonymous_variant	0.63	moxifloxacin
gyrA	9374	c.2073G>C	synonymous_variant	0.58	levofloxacin
gyrA	9374	c.2073G>C	synonymous_variant	0.58	moxifloxacin
gyrA	9377	c.2076A>G	synonymous_variant	0.55	levofloxacin	Not assoc w R - Interim
gyrA	9377	c.2076A>G	synonymous_variant	0.55	moxifloxacin	Not assoc w R - Interim
gyrA	9383	c.2082T>G	synonymous_variant	0.55	levofloxacin	Not assoc w R - Interim
gyrA	9383	c.2082T>G	synonymous_variant	0.55	moxifloxacin	Not assoc w R - Interim
gyrA	9386	c.2085T>C	synonymous_variant	0.53	levofloxacin	Not assoc w R - Interim
gyrA	9386	c.2085T>C	synonymous_variant	0.53	moxifloxacin	Not assoc w R - Interim
gyrA	9389	c.2088C>T	synonymous_variant	0.53	levofloxacin
gyrA	9389	c.2088C>T	synonymous_variant	0.53	moxifloxacin
gyrA	9395	c.2094G>C	synonymous_variant	0.56	levofloxacin	Not assoc w R - Interim
gyrA	9395	c.2094G>C	synonymous_variant	0.56	moxifloxacin	Not assoc w R - Interim
gyrA	9398	c.2097T>C	synonymous_variant	0.56	levofloxacin
gyrA	9398	c.2097T>C	synonymous_variant	0.56	moxifloxacin
gyrA	9413	c.2112G>C	synonymous_variant	0.53	levofloxacin
gyrA	9413	c.2112G>C	synonymous_variant	0.53	moxifloxacin
gyrA	9419	c.2118T>C	synonymous_variant	0.32	levofloxacin
gyrA	9419	c.2118T>C	synonymous_variant	0.32	moxifloxacin
gyrA	9420	p.Ile707Ala	missense_variant	0.31	levofloxacin
gyrA	9420	p.Ile707Ala	missense_variant	0.31	moxifloxacin
gyrA	9428	c.2127C>T	synonymous_variant	0.3	levofloxacin
gyrA	9428	c.2127C>T	synonymous_variant	0.3	moxifloxacin
gyrA	9429	p.Arg710Tyr	missense_variant	0.3	levofloxacin
gyrA	9429	p.Arg710Tyr	missense_variant	0.3	moxifloxacin
gyrA	9435	c.2134C>T	synonymous_variant	0.31	levofloxacin
gyrA	9435	c.2134C>T	synonymous_variant	0.31	moxifloxacin
gyrA	9443	c.2142G>C	synonymous_variant	0.3	levofloxacin	Not assoc w R - Interim
gyrA	9443	c.2142G>C	synonymous_variant	0.3	moxifloxacin	Not assoc w R - Interim
gyrA	9452	c.2151G>T	synonymous_variant	0.31	levofloxacin
gyrA	9452	c.2151G>T	synonymous_variant	0.31	moxifloxacin
gyrA	9458	c.2157A>G	synonymous_variant	0.31	levofloxacin
gyrA	9458	c.2157A>G	synonymous_variant	0.31	moxifloxacin
gyrA	9467	c.2166T>C	synonymous_variant	0.3	levofloxacin	Not assoc w R - Interim
gyrA	9467	c.2166T>C	synonymous_variant	0.3	moxifloxacin	Not assoc w R - Interim
Rv0010c	13852	c.-296_-294delTTAinsCG	upstream_gene_variant	0.33	isoniazid
Rv0010c	13860	c.-302A>G	upstream_gene_variant	0.32	isoniazid
Rv0010c	13864	c.-306A>G	upstream_gene_variant	0.32	isoniazid
Rv0010c	13876	c.-318G>C	upstream_gene_variant	0.36	isoniazid
Rv0010c	13879	c.-321T>C	upstream_gene_variant	0.36	isoniazid
Rv0010c	13890	c.-332T>C	upstream_gene_variant	0.39	isoniazid
Rv0010c	13893	c.-335T>G	upstream_gene_variant	0.39	isoniazid
Rv0010c	13897	c.-339C>T	upstream_gene_variant	0.38	isoniazid
Rv0010c	13903	c.-345A>G	upstream_gene_variant	0.38	isoniazid
Rv0010c	13909	c.-351G>C	upstream_gene_variant	0.41	isoniazid
fgd1	491106	c.324T>C	synonymous_variant	0.22	clofazimine
					pretomanid
					delamanid
fgd1	491121	c.339A>G	synonymous_variant	0.33	clofazimine
					pretomanid
					delamanid
fgd1	491130	c.348C>G	synonymous_variant	0.36	clofazimine
					pretomanid
					delamanid
fgd1	491144	p.Ala121Asp	missense_variant	0.39	clofazimine
					pretomanid
					delamanid
fgd1	491151	c.369G>A	synonymous_variant	0.37	clofazimine
					pretomanid
					delamanid
fgd1	491181	c.399T>C	synonymous_variant	0.39	clofazimine
					pretomanid
					delamanid
fgd1	491184	c.402A>G	synonymous_variant	0.4	clofazimine
					pretomanid
					delamanid
fgd1	491191	p.Gly137Arg	missense_variant	0.4	clofazimine
					pretomanid
					delamanid
fgd1	491202	c.420G>C	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fgd1	491203	p.Gln141Glu	missense_variant	0.43	clofazimine
					pretomanid
					delamanid
fgd1	491212	p.Ser144Arg	missense_variant	0.44	clofazimine
					pretomanid
					delamanid
fgd1	491217	c.435T>C	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fgd1	491232	c.450T>C	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fgd1	491241	p.Asp153Glu	missense_variant	0.47	clofazimine
					pretomanid
					delamanid
fgd1	491244	c.462T>C	synonymous_variant	0.45	clofazimine
					pretomanid
					delamanid
fgd1	491259	c.477T>C	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fgd1	491283	p.Asp167Glu	missense_variant	0.42	clofazimine
					pretomanid
					delamanid
fgd1	491337	c.555C>G	synonymous_variant	0.37	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fgd1	491607	c.825G>C	synonymous_variant	0.35	clofazimine
					pretomanid
					delamanid
fgd1	491610	c.828A>G	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fgd1	491616	c.834A>G	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fgd1	491620	p.Ile280Val	missense_variant	0.4	clofazimine
					pretomanid
					delamanid
fgd1	491643	c.861G>A	synonymous_variant	0.46	clofazimine
					pretomanid
					delamanid
fgd1	491646	c.864G>C	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fgd1	491649	c.867C>T	synonymous_variant	0.48	clofazimine
					pretomanid
					delamanid
fgd1	491658	c.876A>G	synonymous_variant	0.48	clofazimine
					pretomanid
					delamanid
fgd1	491661	c.879C>G	synonymous_variant	0.48	clofazimine
					pretomanid
					delamanid
fgd1	491673	c.891A>C	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fgd1	491676	c.894T>C	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fgd1	491679	c.897A>G	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fgd1	491687	p.Thr302Lys	missense_variant	0.44	clofazimine
					pretomanid
					delamanid
fgd1	491697	c.915G>C	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fgd1	491709	c.927A>G	synonymous_variant	0.36	clofazimine
					pretomanid
					delamanid
fgd1	491712	c.930T>C	synonymous_variant	0.36	clofazimine
					pretomanid
					delamanid
fgd1	491718	c.936A>G	synonymous_variant	0.35	clofazimine
					pretomanid
					delamanid
fgd1	491721	c.939A>C	synonymous_variant	0.35	clofazimine
					pretomanid
					delamanid
fgd1	491724	c.942A>T	synonymous_variant	0.35	clofazimine
					pretomanid
					delamanid
fgd1	491727	c.945T>C	synonymous_variant	0.33	clofazimine
					pretomanid
					delamanid
fgd1	491742	c.960T>C	synonymous_variant	0.27	clofazimine	Not assoc w R
					pretomanid
					delamanid	Not assoc w R - Interim
ccsA	619507	c.-384A>G	upstream_gene_variant	0.76	capreomycin
					amikacin
					kanamycin
ccsA	619528	c.-363C>G	upstream_gene_variant	0.74	capreomycin
					amikacin
					kanamycin
ccsA	619531	c.-360T>C	upstream_gene_variant	0.72	capreomycin
					amikacin
					kanamycin
ccsA	619535	c.-356_-354delCAAinsGCG	upstream_gene_variant	0.72	capreomycin
					amikacin
					kanamycin
ccsA	619543	c.-348C>G	upstream_gene_variant	0.74	capreomycin
					amikacin
					kanamycin
ccsA	619552	c.-339A>G	upstream_gene_variant	0.76	capreomycin
					amikacin
					kanamycin
ccsA	619555	c.-336C>G	upstream_gene_variant	0.75	capreomycin
					amikacin
					kanamycin
ccsA	619561	c.-330G>C	upstream_gene_variant	0.75	capreomycin
					amikacin
					kanamycin
ccsA	619570	c.-321G>C	upstream_gene_variant	0.78	capreomycin
					amikacin
					kanamycin
ccsA	619574	c.-317G>A	upstream_gene_variant	0.78	capreomycin
					amikacin
					kanamycin
ccsA	619579	c.-312G>C	upstream_gene_variant	0.78	capreomycin
					amikacin
					kanamycin
ccsA	619584	c.-307A>T	upstream_gene_variant	0.78	capreomycin
					amikacin
					kanamycin
ccsA	619591	c.-300G>C	upstream_gene_variant	0.77	capreomycin
					amikacin
					kanamycin
ccsA	619609	c.-282G>C	upstream_gene_variant	0.77	capreomycin
					amikacin
					kanamycin
ccsA	619634	c.-257T>A	upstream_gene_variant	0.71	capreomycin
					amikacin
					kanamycin
ccsA	619645	c.-246G>C	upstream_gene_variant	0.67	capreomycin
					amikacin
					kanamycin
ccsA	619654	c.-237A>G	upstream_gene_variant	0.61	capreomycin
					amikacin
					kanamycin
ccsA	619668	c.-223_-222delCGinsGC	upstream_gene_variant	0.55	capreomycin
					amikacin
					kanamycin
ccsA	619672	c.-219A>T	upstream_gene_variant	0.56	capreomycin
					amikacin
					kanamycin
ccsA	619676	c.-215C>G	upstream_gene_variant	0.57	capreomycin
					amikacin
					kanamycin
ccsA	619697	c.-194_-192delAGGinsCC	upstream_gene_variant	0.42	capreomycin
					amikacin
					kanamycin
ccsA	619705	c.-186G>C	upstream_gene_variant	0.33	capreomycin
					amikacin
					kanamycin
ccsA	620226	c.336G>A	synonymous_variant	0.49	capreomycin
					amikacin
					kanamycin
ccsA	620245	c.355T>C	synonymous_variant	0.55	capreomycin
					amikacin
					kanamycin
ccsA	620249	p.Ser120Cys	missense_variant	0.55	capreomycin
					amikacin
					kanamycin
ccsA	620254	c.364_366delCTCinsTG	frameshift_variant&missense_variant	0.55	capreomycin
					amikacin
					kanamycin
ccsA	620265	c.375C>G	synonymous_variant	0.61	capreomycin
					amikacin
					kanamycin
ccsA	620268	c.378G>C	synonymous_variant	0.62	capreomycin
					amikacin
					kanamycin
ccsA	620283	c.393T>C	synonymous_variant	0.62	capreomycin
					amikacin
					kanamycin
ccsA	620284	c.394_396delGCGinsCC	frameshift_variant&missense_variant	0.62	capreomycin
					amikacin
					kanamycin
ccsA	620288	p.Arg133Gln	missense_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620295	c.405G>T	synonymous_variant	0.62	capreomycin
					amikacin
					kanamycin
ccsA	620298	c.408G>C	synonymous_variant	0.64	capreomycin
					amikacin
					kanamycin
ccsA	620310	c.420C>T	synonymous_variant	0.71	capreomycin
					amikacin
					kanamycin
ccsA	620317	c.427_429delGTCinsCG	frameshift_variant&missense_variant	0.7	capreomycin
					amikacin
					kanamycin
ccsA	620340	c.450C>G	synonymous_variant	0.73	capreomycin
					amikacin
					kanamycin
ccsA	620346	c.456C>G	synonymous_variant	0.74	capreomycin
					amikacin
					kanamycin
ccsA	620362	p.Ala158Thr	missense_variant	0.73	capreomycin
					amikacin
					kanamycin
ccsA	620367	c.477T>C	synonymous_variant	0.72	capreomycin
					amikacin
					kanamycin
ccsA	620373	c.483C>G	synonymous_variant	0.72	capreomycin
					amikacin
					kanamycin
ccsA	620376	c.486G>C	synonymous_variant	0.71	capreomycin
					amikacin
					kanamycin
ccsA	620385	c.495G>C	synonymous_variant	0.71	capreomycin
					amikacin
					kanamycin
ccsA	620388	c.498A>G	synonymous_variant	0.71	capreomycin
					amikacin
					kanamycin
ccsA	620389	c.499C>T	synonymous_variant	0.7	capreomycin
					amikacin
					kanamycin
ccsA	620412	c.522T>C	synonymous_variant	0.66	capreomycin
					amikacin
					kanamycin
ccsA	620415	c.525T>C	synonymous_variant	0.64	capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
ccsA	620424	c.534G>C	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620433	c.543C>G	synonymous_variant	0.64	capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
ccsA	620436	c.546T>A	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620439	c.549T>C	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620442	c.552G>C	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620445	c.555A>G	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620460	c.570T>G	synonymous_variant	0.57	capreomycin
					amikacin
					kanamycin
ccsA	620461	p.Val191Ile	missense_variant	0.55	capreomycin
					amikacin
					kanamycin
ccsA	620481	c.591T>G	synonymous_variant	0.36	capreomycin
					amikacin
					kanamycin
ccsA	620482	p.Val198Leu	missense_variant	0.35	capreomycin
					amikacin
					kanamycin
ccsA	620490	c.600A>C	synonymous_variant	0.36	capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
ccsA	620569	c.679_681delGGAinsCC	frameshift_variant&missense_variant	0.29	capreomycin
					amikacin
					kanamycin
ccsA	620583	c.693G>C	synonymous_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	620586	c.696C>G	synonymous_variant	0.44	capreomycin
					amikacin
					kanamycin
ccsA	620598	c.708C>G	synonymous_variant	0.5	capreomycin
					amikacin
					kanamycin
ccsA	620601	c.711C>T	synonymous_variant	0.5	capreomycin
					amikacin
					kanamycin
ccsA	620604	c.714C>G	synonymous_variant	0.5	capreomycin
					amikacin
					kanamycin
ccsA	620607	c.717T>C	synonymous_variant	0.48	capreomycin
					amikacin
					kanamycin
ccsA	620613	c.723C>G	synonymous_variant	0.49	capreomycin
					amikacin
					kanamycin
ccsA	620622	c.732G>C	synonymous_variant	0.52	capreomycin
					amikacin
					kanamycin
ccsA	620625	c.735A>C	synonymous_variant	0.52	capreomycin
					amikacin
					kanamycin
ccsA	620631	c.741T>G	synonymous_variant	0.56	capreomycin
					amikacin
					kanamycin
ccsA	620646	c.756G>A	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620649	c.759A>G	synonymous_variant	0.62	capreomycin
					amikacin
					kanamycin
ccsA	620659	c.769_771delCGCinsAG	frameshift_variant&missense_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620664	c.774C>T	synonymous_variant	0.63	capreomycin
					amikacin
					kanamycin
ccsA	620682	c.792G>A	synonymous_variant	0.64	capreomycin
					amikacin
					kanamycin
ccsA	620688	c.798G>C	synonymous_variant	0.65	capreomycin
					amikacin
					kanamycin
ccsA	620710	c.820_822delGTGinsAA	frameshift_variant&missense_variant	0.6	capreomycin
					amikacin
					kanamycin
ccsA	620718	c.828G>C	synonymous_variant	0.59	capreomycin
					amikacin
					kanamycin
ccsA	620721	c.831G>C	synonymous_variant	0.6	capreomycin
					amikacin
					kanamycin
ccsA	620733	c.843G>C	synonymous_variant	0.56	capreomycin
					amikacin
					kanamycin
ccsA	620734	c.844C>A	synonymous_variant	0.54	capreomycin
					amikacin
					kanamycin
ccsA	620739	c.849A>G	synonymous_variant	0.54	capreomycin
					amikacin
					kanamycin
ccsA	620742	c.852G>C	synonymous_variant	0.54	capreomycin
					amikacin
					kanamycin
ccsA	620745	c.855G>C	synonymous_variant	0.54	capreomycin
					amikacin
					kanamycin
ccsA	620748	c.858T>A	synonymous_variant	0.54	capreomycin
					amikacin
					kanamycin
ccsA	620763	c.873G>A	synonymous_variant	0.53	capreomycin
					amikacin
					kanamycin
ccsA	620769	c.879C>G	synonymous_variant	0.53	capreomycin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
ccsA	620778	c.888T>C	synonymous_variant	0.51	capreomycin
					amikacin
					kanamycin
ccsA	620784	c.894C>G	synonymous_variant	0.49	capreomycin
					amikacin
					kanamycin
ccsA	620790	c.900C>T	synonymous_variant	0.45	capreomycin
					amikacin
					kanamycin
ccsA	620796	c.906C>G	synonymous_variant	0.41	capreomycin
					amikacin
					kanamycin
ccsA	620809	c.919C>T	synonymous_variant	0.38	capreomycin
					amikacin
					kanamycin
ccsA	620823	c.933C>T	synonymous_variant	0.31	capreomycin
					amikacin
					kanamycin
Rv0565c	656156	p.Gln439Lys	missense_variant	0.21	ethionamide
Rv0565c	656157	c.1314T>C	synonymous_variant	0.25	ethionamide
Rv0565c	656166	c.1305C>G	synonymous_variant	0.48	ethionamide
Rv0565c	656172	c.1299A>G	synonymous_variant	0.49	ethionamide
Rv0565c	656179	p.Asp431Thr	missense_variant	0.54	ethionamide
Rv0565c	656192	p.Asp427Asn	missense_variant	0.6	ethionamide	Uncertain significance
Rv0565c	656196	p.Leu425Arg	missense_variant	0.61	ethionamide
Rv0565c	656219	p.His418Tyr	missense_variant	0.64	ethionamide
Rv0565c	656220	c.1251A>C	synonymous_variant	0.64	ethionamide
Rv0565c	656223	c.1248T>C	synonymous_variant	0.64	ethionamide	Not assoc w R - Interim
Rv0565c	656226	c.1243_1245delGCCinsTT	frameshift_variant&missense_variant	0.65	ethionamide	Uncertain significance
Rv0565c	656238	p.Ala411Glu	missense_variant	0.65	ethionamide
Rv0565c	656243	p.Leu410Met	missense_variant	0.65	ethionamide
Rv0565c	656244	c.1227A>C	synonymous_variant	0.64	ethionamide
Rv0565c	656265	c.1206G>C	synonymous_variant	0.64	ethionamide
Rv0565c	656268	p.Met401Ile	missense_variant	0.65	ethionamide
Rv0565c	656277	c.1194C>G	synonymous_variant	0.62	ethionamide
Rv0565c	656289	c.1182C>G	synonymous_variant	0.62	ethionamide
Rv0565c	656298	c.1173G>C	synonymous_variant	0.62	ethionamide
Rv0565c	656304	c.1167T>C	synonymous_variant	0.62	ethionamide
Rv0565c	656325	c.1146C>G	synonymous_variant	0.56	ethionamide
Rv0565c	656358	c.1113T>C	synonymous_variant	0.47	ethionamide	Not assoc w R - Interim
Rv0565c	656361	c.1110C>G	synonymous_variant	0.47	ethionamide
Rv0565c	656364	c.1107T>C	synonymous_variant	0.48	ethionamide
Rv0565c	656367	c.1101_1104delTCGGinsGC	frameshift_variant&synonymous_variant	0.48	ethionamide	Uncertain significance
Rv0565c	656371	p.Pro367His	missense_variant	0.46	ethionamide
Rv0565c	656375	c.1095_1096insAA	frameshift_variant	0.48	ethionamide	Uncertain significance
Rv0565c	656383	p.Val363Asn	missense_variant	0.51	ethionamide
Rv0565c	656391	c.1080C>G	synonymous_variant	0.54	ethionamide
Rv0565c	656402	p.Ala357Thr	missense_variant	0.54	ethionamide
Rv0565c	656412	c.1059T>G	synonymous_variant	0.56	ethionamide
Rv0565c	656418	c.1053A>G	synonymous_variant	0.58	ethionamide
Rv0565c	656423	c.1048T>C	synonymous_variant	0.6	ethionamide
Rv0565c	656448	c.1021_1023delATTinsGC	frameshift_variant&missense_variant	0.59	ethionamide	Uncertain significance
Rv0565c	656454	c.1017G>C	synonymous_variant	0.56	ethionamide
Rv0565c	656457	c.1014T>C	synonymous_variant	0.58	ethionamide
Rv0565c	656469	c.1002T>C	synonymous_variant	0.56	ethionamide
Rv0565c	656475	c.996A>G	synonymous_variant	0.55	ethionamide
Rv0565c	656484	c.987T>C	synonymous_variant	0.54	ethionamide
Rv0565c	656487	c.984T>C	synonymous_variant	0.5	ethionamide	Not assoc w R - Interim
Rv0565c	656493	c.978C>G	synonymous_variant	0.52	ethionamide
Rv0565c	656502	c.969C>T	synonymous_variant	0.52	ethionamide
Rv0565c	656511	c.960T>C	synonymous_variant	0.53	ethionamide	Not assoc w R - Interim
Rv0565c	656526	p.Glu315Asp	missense_variant	0.5	ethionamide
Rv0565c	656535	c.936C>G	synonymous_variant	0.46	ethionamide
Rv0565c	656539	p.Ser311Ala	missense_variant	0.48	ethionamide
Rv0565c	656542	p.Thr310Ser	missense_variant	0.49	ethionamide
Rv0565c	656550	c.919_921delAACinsGG	frameshift_variant&missense_variant	0.45	ethionamide	Uncertain significance
Rv0565c	656568	c.903G>C	synonymous_variant	0.35	ethionamide
Rv0565c	656901	c.570C>G	synonymous_variant	0.36	ethionamide
Rv0565c	656904	c.567G>C	synonymous_variant	0.38	ethionamide
Rv0565c	656924	p.Ile183Val	missense_variant	0.49	ethionamide
Rv0565c	656936	p.Thr179Ala	missense_variant	0.48	ethionamide
Rv0565c	656940	c.531C>T	synonymous_variant	0.44	ethionamide	Not assoc w R - Interim
Rv0565c	656946	c.525T>C	synonymous_variant	0.41	ethionamide
Rv0565c	656952	c.519A>C	synonymous_variant	0.38	ethionamide	Not assoc w R - Interim
Rv0565c	656967	c.504T>C	synonymous_variant	0.42	ethionamide
Rv0565c	656973	c.498A>G	synonymous_variant	0.42	ethionamide
Rv0565c	656978	p.Ala165Thr	missense_variant	0.44	ethionamide
Rv0565c	656982	p.Gly163Gln	missense_variant	0.44	ethionamide
Rv0565c	656985	c.486T>C	synonymous_variant	0.43	ethionamide
Rv0565c	656990	p.Lys161Glu	missense_variant	0.44	ethionamide
Rv0565c	657000	p.Gly157Pro	missense_variant	0.44	ethionamide
Rv0565c	657027	c.444T>C	synonymous_variant	0.44	ethionamide
Rv0565c	657138	c.331_333delGCAinsTG	frameshift_variant&missense_variant	0.33	ethionamide	Uncertain significance
Rv0565c	657144	c.327T>G	synonymous_variant	0.37	ethionamide
Rv0565c	657155	p.Asn106Asp	missense_variant	0.44	ethionamide
Rv0565c	657160	p.Glu104Arg	missense_variant	0.45	ethionamide
Rv0565c	657171	c.300T>C	synonymous_variant	0.52	ethionamide
Rv0565c	657187	p.His95Arg	missense_variant	0.48	ethionamide
Rv0565c	657189	c.282C>G	synonymous_variant	0.49	ethionamide
Rv0565c	657192	p.Met93Thr	missense_variant	0.49	ethionamide
Rv0565c	657196	p.Asp92Ala	missense_variant	0.49	ethionamide
Rv0565c	657200	p.Thr91Ala	missense_variant	0.49	ethionamide	Uncertain significance
Rv0565c	657201	c.270C>G	synonymous_variant	0.5	ethionamide
Rv0565c	657219	p.Ala84Val	missense_variant	0.61	ethionamide
Rv0565c	657231	c.238_240delATCinsGG	frameshift_variant&missense_variant	0.67	ethionamide	Uncertain significance
Rv0565c	657237	c.234A>G	synonymous_variant	0.67	ethionamide
Rv0565c	657259	p.Tyr71Phe	missense_variant	0.71	ethionamide
Rv0565c	657261	c.210C>G	synonymous_variant	0.72	ethionamide
Rv0565c	657264	c.207T>C	synonymous_variant	0.73	ethionamide
Rv0565c	657267	c.204G>C	synonymous_variant	0.73	ethionamide
Rv0565c	657300	c.171C>G	synonymous_variant	0.72	ethionamide
Rv0565c	657318	c.153T>C	synonymous_variant	0.68	ethionamide
Rv0565c	657324	c.147C>G	synonymous_variant	0.67	ethionamide
Rv0565c	657327	c.144C>G	synonymous_variant	0.67	ethionamide
Rv0565c	657337	p.Arg45Gln	missense_variant	0.7	ethionamide	Uncertain significance
Rv0565c	657342	c.129T>C	synonymous_variant	0.7	ethionamide
Rv0565c	657347	c.124A>C	synonymous_variant	0.68	ethionamide
Rv0565c	657348	c.123A>G	synonymous_variant	0.67	ethionamide
Rv0565c	657356	p.Ile39Val	missense_variant	0.67	ethionamide
Rv0565c	657372	c.99G>C	synonymous_variant	0.58	ethionamide
Rv0565c	657375	c.96C>T	synonymous_variant	0.57	ethionamide
Rv0565c	657385	p.Ile29Thr	missense_variant	0.5	ethionamide
Rv0565c	657399	c.72G>C	synonymous_variant	0.39	ethionamide
Rv0565c	657403	p.Gly23Asp	missense_variant	0.35	ethionamide
Rv0565c	657405	c.64_66delCTGinsAT	frameshift_variant&missense_variant	0.35	ethionamide	Uncertain significance
Rv0565c	657408	c.63A>C	synonymous_variant	0.35	ethionamide
Rv0565c	657423	c.48C>A	synonymous_variant	0.21	ethionamide
Rv0565c	657632	c.-162G>A	upstream_gene_variant	0.34	ethionamide
Rv0565c	657649	c.-179G>A	upstream_gene_variant	0.34	ethionamide
Rv0565c	657671	c.-201A>G	upstream_gene_variant	0.44	ethionamide
Rv0565c	657678	c.-209_-208delAAinsTC	upstream_gene_variant	0.45	ethionamide
Rv0565c	657680	c.-210G>C	upstream_gene_variant	0.49	ethionamide
Rv0565c	657689	c.-220_-219delCAinsAC	upstream_gene_variant	0.5	ethionamide
Rv0565c	657701	c.-231C>G	upstream_gene_variant	0.55	ethionamide
Rv0565c	657734	c.-264T>C	upstream_gene_variant	0.7	ethionamide
hadA	731682	c.-248C>G	upstream_gene_variant	0.62	isoniazid
hadA	731687	c.-243_-242insCACAGATCTTTT	upstream_gene_variant	0.62	isoniazid
hadA	731693	c.-237C>A	upstream_gene_variant	0.62	isoniazid
hadA	731696	c.-233_-232delTT	upstream_gene_variant	0.63	isoniazid
hadA	731708	c.-222G>C	upstream_gene_variant	0.62	isoniazid
hadA	731710	c.-220A>T	upstream_gene_variant	0.62	isoniazid
hadA	731711	c.-219T>C	upstream_gene_variant	0.63	isoniazid
hadA	731717	c.-213T>G	upstream_gene_variant	0.67	isoniazid
hadA	731732	c.-198G>A	upstream_gene_variant	0.72	isoniazid
hadA	731747	c.-183T>C	upstream_gene_variant	0.75	isoniazid
hadA	731774	c.-156T>C	upstream_gene_variant	0.61	isoniazid
hadA	731789	c.-141A>G	upstream_gene_variant	0.48	isoniazid
hadA	731792	c.-138G>A	upstream_gene_variant	0.45	isoniazid
hadA	731801	c.-129C>G	upstream_gene_variant	0.4	isoniazid
hadA	731816	c.-114G>A	upstream_gene_variant	0.38	isoniazid
hadA	731840	c.-90G>C	upstream_gene_variant	0.38	isoniazid
hadA	731843	c.-87T>C	upstream_gene_variant	0.37	isoniazid
hadA	731849	c.-81C>T	upstream_gene_variant	0.37	isoniazid
hadA	731852	c.-78A>G	upstream_gene_variant	0.36	isoniazid
hadA	731864	c.-66C>T	upstream_gene_variant	0.24	isoniazid
hadA	732229	c.300C>G	synonymous_variant	0.28	isoniazid	Not assoc w R - Interim
hadA	732238	c.309G>C	synonymous_variant	0.33	isoniazid
hadA	732253	c.324T>C	synonymous_variant	0.4	isoniazid
hadA	732259	c.330T>C	synonymous_variant	0.41	isoniazid
hadA	732268	c.339T>G	synonymous_variant	0.4	isoniazid
hadA	732270	p.Glu114Val	missense_variant	0.4	isoniazid
hadA	732272	p.Ala115Ser	missense_variant	0.41	isoniazid
hadA	732295	c.366G>C	synonymous_variant	0.54	isoniazid
hadA	732305	p.Ile126Val	missense_variant	0.56	isoniazid
hadA	732308	p.Val127Ile	missense_variant	0.57	isoniazid
hadA	732321	p.Glu131Ala	missense_variant	0.64	isoniazid
hadA	732329	p.Leu134Val	missense_variant	0.68	isoniazid	Uncertain significance
hadA	732337	c.408G>A	synonymous_variant	0.71	isoniazid
hadA	732378	c.450_452dupAGA	disruptive_inframe_insertion	0.68	isoniazid
hadA	732396	p.Gly156Ala	missense_variant	0.65	isoniazid
hadA	732398	p.Ala157Thr	missense_variant	0.64	isoniazid
nusG	734078	c.-176C>G	upstream_gene_variant	0.44	rifampicin	Uncertain significance
nusG	734093	c.-161A>C	upstream_gene_variant	0.42	rifampicin
nusG	734102	c.-152G>C	upstream_gene_variant	0.43	rifampicin
nusG	734111	c.-143A>G	upstream_gene_variant	0.42	rifampicin
nusG	734114	c.-140A>G	upstream_gene_variant	0.42	rifampicin
nusG	734120	c.-134T>C	upstream_gene_variant	0.42	rifampicin	Uncertain significance
nusG	734123	c.-131C>G	upstream_gene_variant	0.41	rifampicin
nusG	734129	c.-125G>C	upstream_gene_variant	0.42	rifampicin
nusG	734132	c.-122G>C	upstream_gene_variant	0.42	rifampicin
nusG	734135	c.-119G>C	upstream_gene_variant	0.42	rifampicin
nusG	734144	c.-110G>C	upstream_gene_variant	0.42	rifampicin
nusG	734147	c.-107T>C	upstream_gene_variant	0.46	rifampicin
nusG	734173	c.-81C>G	upstream_gene_variant	0.51	rifampicin
nusG	734175	c.-79_-77delGGTinsCTG	upstream_gene_variant	0.52	rifampicin
nusG	734180	c.-74T>G	upstream_gene_variant	0.55	rifampicin	Uncertain significance
nusG	734183	c.-71C>T	upstream_gene_variant	0.52	rifampicin
nusG	734186	c.-68G>C	upstream_gene_variant	0.53	rifampicin	Uncertain significance
nusG	734205	c.-49A>C	upstream_gene_variant	0.5	rifampicin
nusG	734247	c.-7_-6delGAinsC	upstream_gene_variant	0.25	rifampicin
nusG	734250	c.-4A>C	upstream_gene_variant	0.24	rifampicin
nusG	734261	p.Thr3Ser	missense_variant	0.25	rifampicin
nusG	734275	p.Thr8Pro	missense_variant	0.26	rifampicin
nusG	734360	p.Ala36Val	missense_variant	0.25	rifampicin	Uncertain significance
nusG	734364	c.111G>C	synonymous_variant	0.28	rifampicin
nusG	734370	c.117A>G	synonymous_variant	0.33	rifampicin
nusG	734376	c.123G>A	synonymous_variant	0.37	rifampicin
nusG	734407	c.154_156delGTTinsAC	frameshift_variant&missense_variant	0.52	rifampicin
nusG	734421	c.168A>G	synonymous_variant	0.59	rifampicin
nusG	734424	c.171G>A	synonymous_variant	0.6	rifampicin
nusG	734442	c.189G>A	synonymous_variant	0.62	rifampicin
nusG	734451	c.198G>C	synonymous_variant	0.61	rifampicin
nusG	734457	c.204C>G	synonymous_variant	0.6	rifampicin
nusG	734472	c.219T>C	synonymous_variant	0.61	rifampicin
nusG	734475	c.222T>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
nusG	734532	c.279A>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
nusG	734556	c.303C>T	synonymous_variant	0.42	rifampicin
nusG	734559	c.306T>C	synonymous_variant	0.39	rifampicin
nusG	734580	c.327T>C	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
nusG	734589	c.336G>C	synonymous_variant	0.28	rifampicin
nusG	734596	c.343T>C	synonymous_variant	0.27	rifampicin
nusG	734601	c.348C>G	synonymous_variant	0.27	rifampicin
rpoB	760046	c.240G>C	synonymous_variant	0.25	rifampicin
rpoB	760060	p.Tyr85Leu	missense_variant	0.32	rifampicin
rpoB	760067	c.261G>C	synonymous_variant	0.33	rifampicin
rpoB	760070	c.264T>G	synonymous_variant	0.34	rifampicin
rpoB	760091	c.285G>C	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoB	760101	c.295T>C	synonymous_variant	0.51	rifampicin	Not assoc w R - Interim
rpoB	760112	c.306T>C	synonymous_variant	0.54	rifampicin
rpoB	760118	c.312T>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoB	760121	c.315T>C	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoB	760130	p.Asp108Glu	missense_variant	0.56	rifampicin	Uncertain significance
rpoB	760139	c.333A>G	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoB	760142	c.336C>G	synonymous_variant	0.59	rifampicin
rpoB	760181	c.375T>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	760184	c.378A>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	760196	c.390C>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	760223	c.417T>C	synonymous_variant	0.69	rifampicin
rpoB	760235	c.429T>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	760283	c.477G>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoB	760298	c.492G>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoB	760307	c.501T>C	synonymous_variant	0.77	rifampicin
rpoB	760310	c.504G>C	synonymous_variant	0.77	rifampicin
rpoB	760328	c.522G>C	synonymous_variant	0.79	rifampicin
rpoB	760331	c.525G>C	synonymous_variant	0.79	rifampicin
rpoB	760340	c.534G>T	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	760361	c.555T>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	760370	c.564C>G	synonymous_variant	0.84	rifampicin
rpoB	760376	p.Asp190Glu	missense_variant	0.83	rifampicin	Uncertain significance
rpoB	760380	p.Thr192Leu	missense_variant	0.83	rifampicin
rpoB	760406	c.600G>C	synonymous_variant	0.83	rifampicin
rpoB	760412	c.606C>G	synonymous_variant	0.84	rifampicin
rpoB	760424	c.618C>G	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoB	760430	c.624T>C	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoB	760475	c.669A>G	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoB	760481	c.675G>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoB	760484	c.678A>G	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoB	760522	p.Ser239Asn	missense_variant	0.65	rifampicin	Uncertain significance
rpoB	760532	c.726T>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoB	760533	p.Val243Thr	missense_variant	0.58	rifampicin
rpoB	760541	c.735G>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	760547	c.741G>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	760563	p.Arg253Met	missense_variant	0.56	rifampicin	Uncertain significance
rpoB	760591	p.Val262Ala	missense_variant	0.56	rifampicin
rpoB	760611	c.805T>C	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoB	760634	c.828T>C	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoB	760646	c.840C>G	synonymous_variant	0.51	rifampicin	Not assoc w R - Interim
rpoB	760655	c.849A>G	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoB	760661	c.855A>C	synonymous_variant	0.51	rifampicin	Not assoc w R - Interim
rpoB	760670	c.864G>C	synonymous_variant	0.5	rifampicin
rpoB	760674	c.868T>C	synonymous_variant	0.51	rifampicin	Not assoc w R - Interim
rpoB	760679	c.873A>G	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoB	760683	c.877T>C	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoB	760718	c.912C>T	synonymous_variant	0.33	rifampicin
rpoB	760724	c.918T>C	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoB	760730	c.924T>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	760869	p.Val355Ile	missense_variant	0.38	rifampicin	Uncertain significance
rpoB	760886	c.1080A>G	synonymous_variant	0.54	rifampicin
rpoB	760925	c.1119T>C	synonymous_variant	0.73	rifampicin
rpoB	760928	c.1122G>C	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoB	760931	c.1125C>G	synonymous_variant	0.72	rifampicin
rpoB	760934	c.1128C>T	synonymous_variant	0.73	rifampicin
rpoB	760946	c.1140A>G	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoB	760982	c.1176G>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	760985	c.1179G>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	760991	c.1185G>C	synonymous_variant	0.83	rifampicin
rpoB	761006	c.1200C>G	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	761015	c.1209G>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	761021	c.1215G>C	synonymous_variant	0.81	rifampicin
rpoB	761027	c.1221A>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761036	c.1230G>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoB	761037	c.1231T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	761057	c.1251G>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	761102	c.1296A>G	synonymous_variant	0.75	rifampicin
rpoB	761129	c.1323G>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	761132	c.1326G>T	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	761133	c.1327T>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	761150	c.1344A>C	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoB	761153	c.1347G>C	synonymous_variant	0.72	rifampicin
rpoB	761165	c.1359G>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	761180	c.1374A>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoB	761189	c.1383T>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoB	761195	c.1389G>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoB	761207	c.1401C>T	synonymous_variant	0.77	rifampicin
rpoB	761213	c.1407G>C	synonymous_variant	0.79	rifampicin
rpoB	761219	c.1413G>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoB	761249	c.1443A>G	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoB	761255	c.1449T>G	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoB	761261	c.1455G>T	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoB	761306	c.1500C>G	synonymous_variant	0.76	rifampicin
rpoB	761312	c.1506G>C	synonymous_variant	0.75	rifampicin
rpoB	761327	c.1521A>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	761330	c.1524G>C	synonymous_variant	0.7	rifampicin
rpoB	761354	c.1548C>T	synonymous_variant	0.67	rifampicin
rpoB	761360	c.1554T>C	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoB	761362	p.Ser519Thr	missense_variant	0.65	rifampicin
rpoB	761373	p.Val523His	missense_variant	0.63	rifampicin
rpoB	761408	c.1602G>C	synonymous_variant	0.44	rifampicin
rpoB	761414	c.1608A>G	synonymous_variant	0.4	rifampicin	Not assoc w R - Interim
rpoB	761423	c.1617T>C	synonymous_variant	0.31	rifampicin
rpoB	761465	c.1659G>C	synonymous_variant	0.26	rifampicin
rpoB	761477	c.1671C>G	synonymous_variant	0.4	rifampicin
rpoB	761492	c.1686G>C	synonymous_variant	0.51	rifampicin
rpoB	761510	c.1704T>C	synonymous_variant	0.57	rifampicin
rpoB	761537	c.1731C>G	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	761570	c.1764T>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	761573	c.1767C>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	761579	c.1773G>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	761588	c.1782C>T	synonymous_variant	0.69	rifampicin
rpoB	761606	c.1800C>G	synonymous_variant	0.69	rifampicin
rpoB	761612	c.1806G>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	761615	c.1809A>C	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoB	761636	c.1830G>T	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	761645	c.1839C>G	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoB	761648	c.1842T>C	synonymous_variant	0.58	rifampicin
rpoB	761657	c.1851C>G	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	761675	c.1869G>C	synonymous_variant	0.5	rifampicin
rpoB	761747	c.1941G>C	synonymous_variant	0.33	rifampicin
rpoB	761750	c.1944G>C	synonymous_variant	0.35	rifampicin
rpoB	761765	c.1959T>C	synonymous_variant	0.33	rifampicin
rpoB	761772	p.His656Ala	missense_variant	0.32	rifampicin
rpoB	761778	p.Asn658Asp	missense_variant	0.33	rifampicin
rpoB	761791	p.Arg662His	missense_variant	0.33	rifampicin
rpoB	761813	c.2007T>C	synonymous_variant	0.33	rifampicin
rpoB	761815	p.Ala670Glu	missense_variant	0.33	rifampicin
rpoB	761834	c.2028T>C	synonymous_variant	0.38	rifampicin
rpoB	761885	c.2079T>C	synonymous_variant	0.45	rifampicin
rpoB	761906	c.2100C>G	synonymous_variant	0.46	rifampicin
rpoB	761909	c.2103T>C	synonymous_variant	0.47	rifampicin
rpoB	761912	c.2106T>C	synonymous_variant	0.47	rifampicin
rpoB	761915	p.Asp703Glu	missense_variant	0.46	rifampicin
rpoB	761916	p.Asp704Asn	missense_variant	0.46	rifampicin
rpoB	761948	c.2142G>C	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoB	761954	c.2148C>G	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoB	762008	c.2202C>T	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	762014	c.2208C>T	synonymous_variant	0.68	rifampicin
rpoB	762017	c.2211A>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	762053	c.2247T>C	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoB	762062	c.2256T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoB	762065	c.2259T>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	762083	c.2277T>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	762086	c.2280G>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	762101	c.2295C>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	762114	p.Ile770Val	missense_variant	0.67	rifampicin	Uncertain significance
rpoB	762131	c.2325C>G	synonymous_variant	0.63	rifampicin
rpoB	762140	c.2334G>C	synonymous_variant	0.59	rifampicin
rpoB	762143	c.2337T>C	synonymous_variant	0.6	rifampicin
rpoB	762149	c.2343G>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoB	762167	c.2361T>C	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoB	762176	c.2370T>C	synonymous_variant	0.66	rifampicin	Not assoc w R - Interim
rpoB	762185	c.2379G>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoB	762206	c.2400C>G	synonymous_variant	0.69	rifampicin
rpoB	762233	c.2427G>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	762246	c.2440C>T	synonymous_variant	0.73	rifampicin
rpoB	762254	c.2448T>G	synonymous_variant	0.72	rifampicin
rpoB	762257	c.2451C>G	synonymous_variant	0.71	rifampicin
rpoB	762266	c.2460T>C	synonymous_variant	0.72	rifampicin
rpoB	762284	c.2478G>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	762293	c.2487T>C	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoB	762314	c.2508C>T	synonymous_variant	0.77	rifampicin
rpoB	762317	c.2511A>G	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoB	762329	c.2523G>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	762338	c.2532T>C	synonymous_variant	0.8	rifampicin
rpoB	762347	c.2541T>C	synonymous_variant	0.78	rifampicin
rpoB	762362	p.Glu852Asp	missense_variant	0.75	rifampicin
rpoB	762369	c.2563T>C	synonymous_variant	0.75	rifampicin
rpoC	762398	c.-972T>C	upstream_gene_variant	0.76	rifampicin
rpoC	762401	c.-969G>C	upstream_gene_variant	0.75	rifampicin
rpoB	762404	c.2598T>C	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	762410	c.-960T>C	upstream_gene_variant	0.74	rifampicin
rpoB	762413	c.2607G>A	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoB	762416	c.2610A>G	synonymous_variant	0.74	rifampicin	Not assoc w R - Interim
rpoC	762419	c.-951C>G	upstream_gene_variant	0.75	rifampicin
rpoC	762434	c.-936T>C	upstream_gene_variant	0.78	rifampicin
rpoB	762449	c.2643C>A	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	762467	c.-903C>T	upstream_gene_variant	0.79	rifampicin
rpoB	762488	c.2682G>C	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoB	762489	p.Val895Gln	missense_variant	0.72	rifampicin
rpoC	762509	c.-861T>G	upstream_gene_variant	0.73	rifampicin
rpoB	762510	c.2704_2706delGCCinsCG	frameshift_variant&missense_variant	0.72	rifampicin
rpoC	762521	c.-849C>T	upstream_gene_variant	0.71	rifampicin
rpoC	762533	c.-837T>C	upstream_gene_variant	0.68	rifampicin
rpoC	762536	c.-834T>C	upstream_gene_variant	0.66	rifampicin
rpoC	762537	c.-833T>C	upstream_gene_variant	0.66	rifampicin
rpoC	762551	c.-819C>G	upstream_gene_variant	0.66	rifampicin
rpoC	762581	c.-789T>C	upstream_gene_variant	0.44	rifampicin
rpoC	762582	c.-788T>C	upstream_gene_variant	0.45	rifampicin
rpoB	762729	p.Gln975Lys	missense_variant	0.36	rifampicin
rpoB	762736	p.Ala977Glu	missense_variant	0.38	rifampicin
rpoB	762744	p.Gln980Ala	missense_variant	0.37	rifampicin
rpoB	762750	p.Leu982Met	missense_variant	0.4	rifampicin
rpoB	762753	c.2947T>C	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoC	762758	c.-612G>C	upstream_gene_variant	0.45	rifampicin
rpoB	762782	c.2976T>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoB	762785	p.Asp993Glu	missense_variant	0.6	rifampicin	Uncertain significance
rpoB	762788	c.2982G>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	762789	p.Leu995Met	missense_variant	0.6	rifampicin	Uncertain significance
rpoC	762794	c.-576C>G	upstream_gene_variant	0.59	rifampicin
rpoB	762799	p.Ala998Gly	missense_variant	0.6	rifampicin	Uncertain significance
rpoB	762810	c.3004_3006delGCCinsTG	frameshift_variant&missense_variant	0.58	rifampicin
rpoB	762813	p.Met1003Val	missense_variant	0.61	rifampicin
rpoB	762818	c.3012C>G	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	762827	c.3021G>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoB	762857	c.3051C>G	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoB	762860	c.3054G>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoB	762863	c.3057T>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>C	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	762989	c.-381G>C	upstream_gene_variant	0.84	rifampicin
rpoC	763013	c.-357C>G	upstream_gene_variant	0.85	rifampicin
rpoB	763028	c.3222T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	763031	c.3225T>G	synonymous_variant	0.87	rifampicin	Not assoc w R - Interim
rpoB	763034	c.3228C>G	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	763040	c.3234C>G	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoB	763070	c.3264T>C	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoB	763085	c.3279C>G	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoB	763115	c.3309T>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	763136	c.3330C>T	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	763148	c.-222G>C	upstream_gene_variant	0.8	rifampicin
rpoC	763158	c.-212C>T	upstream_gene_variant	0.82	rifampicin
rpoB	763166	c.3360A>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	763190	c.-180C>T	upstream_gene_variant	0.75	rifampicin
rpoC	763202	c.-168A>G	upstream_gene_variant	0.71	rifampicin
rpoC	763205	c.-165G>C	upstream_gene_variant	0.7	rifampicin
rpoC	763206	c.-164_-162delAGTinsTCG	upstream_gene_variant	0.69	rifampicin
rpoB	763214	c.3408T>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoC	763226	c.-144A>G	upstream_gene_variant	0.71	rifampicin
rpoB	763227	c.3421C>T	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoB	763238	c.3432T>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	763253	c.-117G>C	upstream_gene_variant	0.65	rifampicin
rpoC	763256	c.-114G>A	upstream_gene_variant	0.65	rifampicin
rpoB	763268	c.3462C>G	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	763283	c.3477T>C	synonymous_variant	0.51	rifampicin	Not assoc w R - Interim
rpoC	763284	c.-86C>T	upstream_gene_variant	0.51	rifampicin
rpoC	763351	c.-19T>C	upstream_gene_variant	0.3	rifampicin	Uncertain significance
rpoC	763352	c.-18T>A	upstream_gene_variant	0.31	rifampicin	Uncertain significance
rpoC	763402	c.33C>G	synonymous_variant	0.66	rifampicin
rpoC	763411	c.42T>G	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoC	763414	c.45T>C	synonymous_variant	0.69	rifampicin
rpoC	763441	c.72C>T	synonymous_variant	0.76	rifampicin
rpoC	763444	c.75T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	763456	c.87A>G	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	763486	c.117T>G	synonymous_variant	0.8	rifampicin
rpoC	763528	c.159G>A	synonymous_variant	0.72	rifampicin	Not assoc w R - Interim
rpoC	763546	c.177A>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoC	763570	c.201G>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	763573	c.204G>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	763594	c.225C>T	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoC	763633	c.264T>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoC	763636	c.267T>C	synonymous_variant	0.65	rifampicin
rpoC	763660	c.291T>G	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	763675	c.306C>G	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	763696	c.327T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	763702	c.333C>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	763717	c.348T>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoC	763723	c.354G>C	synonymous_variant	0.82	rifampicin
rpoC	763732	c.363C>G	synonymous_variant	0.82	rifampicin
rpoC	763741	c.372C>T	synonymous_variant	0.81	rifampicin
rpoC	763744	c.375G>C	synonymous_variant	0.82	rifampicin
rpoC	763765	c.396T>C	synonymous_variant	0.8	rifampicin
rpoC	763774	c.405G>C	synonymous_variant	0.81	rifampicin
rpoC	763807	c.438T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	763816	c.447C>G	synonymous_variant	0.78	rifampicin
rpoC	763835	p.Ala156Met	missense_variant	0.76	rifampicin
rpoC	763853	p.Val162Ile	missense_variant	0.78	rifampicin
rpoC	763858	c.489A>G	synonymous_variant	0.77	rifampicin
rpoC	763872	p.Gly168Ala	missense_variant	0.75	rifampicin
rpoC	763876	p.Glu169Asp	missense_variant	0.74	rifampicin
rpoC	763877	c.508_510delCTAinsTG	frameshift_variant&stop_gained	0.74	rifampicin
rpoC	763888	c.519G>C	synonymous_variant	0.76	rifampicin
rpoC	763891	c.522G>C	synonymous_variant	0.77	rifampicin
rpoC	763894	c.525A>G	synonymous_variant	0.78	rifampicin
rpoC	763900	c.531G>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	763936	c.567C>G	synonymous_variant	0.8	rifampicin
rpoC	763945	c.576T>C	synonymous_variant	0.8	rifampicin
rpoC	763951	c.582G>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	763960	c.591T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	763991	c.622_624delATCinsCG	frameshift_variant&missense_variant	0.79	rifampicin
rpoC	763996	c.627T>C	synonymous_variant	0.79	rifampicin
rpoC	764002	c.633C>G	synonymous_variant	0.8	rifampicin
rpoC	764005	c.636G>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	764024	c.655_657delTTGinsCC	frameshift_variant&missense_variant	0.8	rifampicin
rpoC	764032	p.Asp221Glu	missense_variant	0.78	rifampicin
rpoC	764040	p.Ser224Thr	missense_variant	0.75	rifampicin
rpoC	764044	c.675T>C	synonymous_variant	0.76	rifampicin
rpoC	764059	c.690G>T	synonymous_variant	0.78	rifampicin
rpoC	764083	c.714A>G	synonymous_variant	0.8	rifampicin
rpoC	764098	c.729A>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	764101	c.732C>G	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	764102	p.Val245Ile	missense_variant	0.78	rifampicin
rpoC	764112	p.Tyr248Phe	missense_variant	0.78	rifampicin
rpoC	764116	c.747C>T	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	764131	c.762T>C	synonymous_variant	0.77	rifampicin
rpoC	764140	c.771C>T	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	764188	c.819A>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	764195	p.Ser276Ile	missense_variant	0.81	rifampicin
rpoC	764203	c.834G>C	synonymous_variant	0.81	rifampicin
rpoC	764206	c.837T>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	764215	c.846A>G	synonymous_variant	0.81	rifampicin
rpoC	764236	c.867G>A	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	764248	c.879C>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	764257	c.888G>C	synonymous_variant	0.81	rifampicin
rpoC	764266	c.897T>C	synonymous_variant	0.81	rifampicin
rpoC	764269	c.900G>C	synonymous_variant	0.82	rifampicin
rpoC	764272	c.903G>C	synonymous_variant	0.82	rifampicin
rpoC	764278	c.909A>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	764338	c.969G>A	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	764353	c.984G>C	synonymous_variant	0.79	rifampicin
rpoC	764365	c.996C>T	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	764380	c.1011G>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	764381	c.1012_1013delTCinsAG	synonymous_variant	0.73	rifampicin
rpoC	764387	c.1018_1020delTTGinsCC	frameshift_variant&missense_variant	0.73	rifampicin
rpoC	764405	c.1036A>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	764419	c.1050C>G	synonymous_variant	0.78	rifampicin
rpoC	764428	c.1059G>C	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	764431	c.1062G>C	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	764434	c.1065A>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	764446	c.1077T>C	synonymous_variant	0.8	rifampicin
rpoC	764449	c.1080G>C	synonymous_variant	0.8	rifampicin
rpoC	764452	c.1083T>C	synonymous_variant	0.81	rifampicin
rpoC	764458	c.1089G>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	764461	c.1092A>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	764489	c.1120C>T	synonymous_variant	0.87	rifampicin
rpoC	764497	c.1128A>G	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	764510	c.1141C>T	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	764521	c.1152T>C	synonymous_variant	0.89	rifampicin	Not assoc w R - Interim
rpoC	764527	c.1158C>T	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	764536	c.1167G>C	synonymous_variant	0.91	rifampicin
rpoC	764539	c.1170C>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	764554	c.1185C>T	synonymous_variant	0.92	rifampicin
rpoC	764560	c.1191T>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	764566	c.1197C>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	764575	c.1206T>G	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	764581	c.1212T>C	synonymous_variant	0.9	rifampicin
rpoC	764593	c.1224C>T	synonymous_variant	0.9	rifampicin
rpoC	764611	c.1242G>T	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	764650	c.1281G>C	synonymous_variant	0.84	rifampicin
rpoC	764651	c.1282_1284delTCGinsAGC	synonymous_variant	0.84	rifampicin
rpoC	764752	c.1383G>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	764764	c.1395T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	764809	c.1440C>T	synonymous_variant	0.78	rifampicin	Not assoc w R
rpoC	764815	c.1446A>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	764827	c.1458G>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	764858	c.1489T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	764872	c.1503A>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	764888	c.1519T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	764911	c.1542A>G	synonymous_variant	0.82	rifampicin
rpoC	764932	c.1563C>A	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	764935	c.1566T>C	synonymous_variant	0.8	rifampicin
rpoC	764948	c.1579T>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	764968	c.1599T>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	764995	c.1626C>G	synonymous_variant	0.78	rifampicin	Not assoc w R
rpoC	765019	c.1650A>G	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	765034	c.1665T>C	synonymous_variant	0.76	rifampicin
rpoC	765040	c.1671T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	765041	c.1672T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	765047	c.1678T>C	synonymous_variant	0.76	rifampicin	Not assoc w R - Interim
rpoC	765053	c.1684_1685delTCinsAG	synonymous_variant	0.74	rifampicin
rpoC	765073	c.1704G>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoC	765076	c.1707A>G	synonymous_variant	0.69	rifampicin
rpoC	765079	c.1710T>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	765082	c.1713G>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	765089	c.1720T>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoC	765103	c.1734G>T	synonymous_variant	0.63	rifampicin
rpoC	765146	p.Pro593Asp	missense_variant	0.25	rifampicin
rpoC	765220	c.1851A>G	synonymous_variant	0.27	rifampicin
rpoC	765233	p.Ala622Ser	missense_variant	0.27	rifampicin
rpoC	765241	c.1872C>T	synonymous_variant	0.27	rifampicin
rpoC	765244	c.1875T>C	synonymous_variant	0.26	rifampicin
rpoC	765247	c.1878C>G	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoC	765248	c.1879T>C	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoC	765251	c.1882_1884delAGCinsTCG	synonymous_variant	0.27	rifampicin
rpoC	765292	c.1923G>C	synonymous_variant	0.61	rifampicin
rpoC	765298	c.1929G>C	synonymous_variant	0.62	rifampicin
rpoC	765300	p.Val644Ala	missense_variant	0.63	rifampicin	Uncertain significance
rpoC	765319	c.1950A>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	765326	p.His653Ala	missense_variant	0.65	rifampicin	Uncertain significance
rpoC	765329	p.Ser654Gly	missense_variant	0.66	rifampicin
rpoC	765346	c.1977C>G	synonymous_variant	0.71	rifampicin
rpoC	765349	c.1980T>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	765352	c.1983G>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	765383	p.Met672Leu	missense_variant	0.73	rifampicin	Uncertain significance
rpoC	765404	p.Leu679Val	missense_variant	0.78	rifampicin
rpoC	765409	c.2040T>C	synonymous_variant	0.79	rifampicin
rpoC	765421	c.2052C>G	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	765478	c.2109T>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoC	765499	c.2130C>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	765529	c.2160C>T	synonymous_variant	0.82	rifampicin
rpoC	765541	c.2172C>G	synonymous_variant	0.8	rifampicin
rpoC	765553	c.2184C>T	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	765556	c.2187G>C	synonymous_variant	0.77	rifampicin
rpoC	765559	c.2190G>C	synonymous_variant	0.78	rifampicin
rpoC	765580	c.2211G>C	synonymous_variant	0.78	rifampicin
rpoC	765613	p.His748Gln	missense_variant	0.77	rifampicin
rpoC	765625	c.2256C>G	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	765631	p.Asp754Glu	missense_variant	0.76	rifampicin
rpoC	765700	c.2331T>C	synonymous_variant	0.78	rifampicin	Not assoc w R - Interim
rpoC	765734	c.2365T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	765739	c.2370G>T	synonymous_variant	0.79	rifampicin
rpoC	765751	c.2382C>G	synonymous_variant	0.77	rifampicin
rpoC	765753	p.Asp795Ala	missense_variant	0.77	rifampicin	Uncertain significance
rpoC	765772	c.2403C>G	synonymous_variant	0.79	rifampicin
rpoC	765784	c.2415C>G	synonymous_variant	0.79	rifampicin
rpoC	765787	c.2418C>T	synonymous_variant	0.79	rifampicin
rpoC	765793	c.2424C>G	synonymous_variant	0.78	rifampicin
rpoC	765796	c.2427C>T	synonymous_variant	0.79	rifampicin
rpoC	765811	c.2442T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	765814	c.2445A>G	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoC	765826	c.2457T>C	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	765835	c.2466C>T	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	765850	c.2481G>C	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoC	765883	c.2514C>G	synonymous_variant	0.82	rifampicin
rpoC	765886	c.2517C>G	synonymous_variant	0.82	rifampicin
rpoC	765892	c.2523T>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	765937	c.2568T>C	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoC	765967	c.2598C>T	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoC	765982	c.2613C>G	synonymous_variant	0.83	rifampicin
rpoC	765994	c.2625A>T	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	766010	c.2641_2642delTCinsAG	synonymous_variant	0.82	rifampicin
rpoC	766021	c.2652G>C	synonymous_variant	0.83	rifampicin
rpoC	766027	c.2658G>C	synonymous_variant	0.83	rifampicin
rpoC	766030	c.2661C>G	synonymous_variant	0.84	rifampicin
rpoC	766036	c.2667C>T	synonymous_variant	0.84	rifampicin
rpoC	766043	p.Gln892Glu	missense_variant	0.82	rifampicin
rpoC	766054	c.2685C>G	synonymous_variant	0.81	rifampicin
rpoC	766082	p.Ala905Gln	missense_variant	0.79	rifampicin
rpoC	766096	c.2727G>C	synonymous_variant	0.79	rifampicin
rpoC	766129	c.2760C>G	synonymous_variant	0.71	rifampicin
rpoC	766135	c.2766G>A	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoC	766141	c.2772C>T	synonymous_variant	0.65	rifampicin
rpoC	766142	c.2773C>T	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoC	766168	c.2799C>T	synonymous_variant	0.6	rifampicin
rpoC	766174	p.Asn935Lys	missense_variant	0.57	rifampicin
rpoC	766178	p.Ile937Val	missense_variant	0.53	rifampicin
rpoC	766185	p.Glu939Ala	missense_variant	0.48	rifampicin
rpoC	766189	c.2820T>C	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoC	766192	c.2823T>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoC	766193	c.2824_2826delCAAinsGG	frameshift_variant&missense_variant	0.46	rifampicin
rpoC	766204	c.2835C>T	synonymous_variant	0.44	rifampicin
rpoC	766207	c.2838T>C	synonymous_variant	0.44	rifampicin
rpoC	766216	c.2847T>C	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoC	766219	p.Asp950Glu	missense_variant	0.42	rifampicin
rpoC	766222	c.2853T>C	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoC	766226	c.2857T>C	synonymous_variant	0.42	rifampicin
rpoC	766231	c.2862T>G	synonymous_variant	0.42	rifampicin
rpoC	766234	c.2865T>C	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoC	766237	c.2868T>C	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoC	766240	c.2871T>C	synonymous_variant	0.41	rifampicin
rpoC	766243	c.2874C>G	synonymous_variant	0.41	rifampicin
rpoC	766258	c.2889T>C	synonymous_variant	0.5	rifampicin
rpoC	766273	c.2904T>C	synonymous_variant	0.48	rifampicin
rpoC	766274	p.Ala969Thr	missense_variant	0.47	rifampicin
rpoC	766280	p.Ser971Gly	missense_variant	0.51	rifampicin
rpoC	766288	c.2919C>G	synonymous_variant	0.53	rifampicin
rpoC	766303	c.2934C>T	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoC	766312	c.2943T>G	synonymous_variant	0.6	rifampicin
rpoC	766327	c.2958C>A	synonymous_variant	0.68	rifampicin
rpoC	766345	c.2976T>C	synonymous_variant	0.7	rifampicin
rpoC	766348	c.2979A>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoC	766357	c.2988C>T	synonymous_variant	0.7	rifampicin
rpoC	766363	c.2994G>C	synonymous_variant	0.72	rifampicin
rpoC	766381	c.3012C>T	synonymous_variant	0.75	rifampicin
rpoC	766384	c.3015A>G	synonymous_variant	0.75	rifampicin
rpoC	766408	c.3039C>G	synonymous_variant	0.77	rifampicin
rpoC	766411	c.3042C>G	synonymous_variant	0.78	rifampicin
rpoC	766426	c.3057C>T	synonymous_variant	0.82	rifampicin
rpoC	766447	c.3078T>C	synonymous_variant	0.8	rifampicin
rpoC	766462	c.3093G>C	synonymous_variant	0.77	rifampicin
rpoC	766483	c.3114G>C	synonymous_variant	0.74	rifampicin
rpoC	766484	c.3115_3117delGTAinsAC	frameshift_variant&missense_variant	0.74	rifampicin
rpoC	766492	c.3123T>C	synonymous_variant	0.77	rifampicin
rpoC	766522	c.3153C>G	synonymous_variant	0.77	rifampicin
rpoC	766528	c.3159T>C	synonymous_variant	0.77	rifampicin
rpoC	766531	c.3162G>C	synonymous_variant	0.76	rifampicin
rpoC	766540	p.Asp1057Glu	missense_variant	0.78	rifampicin
rpoC	766549	c.3180G>C	synonymous_variant	0.78	rifampicin
rpoC	766573	c.3204T>C	synonymous_variant	0.76	rifampicin
rpoC	766582	c.3213C>G	synonymous_variant	0.74	rifampicin
rpoC	766583	c.3214_3216delGGTinsAC	frameshift_variant&missense_variant	0.73	rifampicin
rpoC	766591	c.3222A>G	synonymous_variant	0.73	rifampicin
rpoC	766594	c.3225G>C	synonymous_variant	0.73	rifampicin
rpoC	766597	c.3228C>G	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoC	766607	p.Ile1080Leu	missense_variant	0.74	rifampicin
rpoC	766630	c.3261G>C	synonymous_variant	0.75	rifampicin
rpoC	766657	c.3288A>G	synonymous_variant	0.75	rifampicin
rpoC	766672	c.3303T>C	synonymous_variant	0.74	rifampicin
rpoC	766673	p.Gly1102Asn	missense_variant	0.74	rifampicin
rpoC	766726	c.3357T>C	synonymous_variant	0.8	rifampicin
rpoC	766738	c.3369G>C	synonymous_variant	0.8	rifampicin
rpoC	766765	c.3396A>C	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoC	766774	c.3405T>C	synonymous_variant	0.85	rifampicin
rpoC	766801	c.3432C>G	synonymous_variant	0.84	rifampicin
rpoC	766804	c.3435A>G	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	766861	c.3492G>C	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	766864	c.3495G>C	synonymous_variant	0.85	rifampicin
rpoC	766900	c.3531T>C	synonymous_variant	0.84	rifampicin
rpoC	766933	c.3564A>G	synonymous_variant	0.84	rifampicin
rpoC	766945	c.3576A>G	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	766963	c.3594T>C	synonymous_variant	0.86	rifampicin	Not assoc w R - Interim
rpoC	766972	c.3603G>C	synonymous_variant	0.85	rifampicin
rpoC	766996	c.3627C>T	synonymous_variant	0.84	rifampicin	Not assoc w R - Interim
rpoC	767009	c.3640_3642delTCGinsAGC	synonymous_variant	0.83	rifampicin
rpoC	767014	c.3645G>C	synonymous_variant	0.83	rifampicin
rpoC	767033	c.3664_3666delTCGinsAGC	synonymous_variant	0.82	rifampicin
rpoC	767059	c.3690T>G	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	767062	c.3693C>A	synonymous_variant	0.84	rifampicin
rpoC	767098	c.3729T>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoC	767119	c.3750A>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	767134	c.3765C>A	synonymous_variant	0.81	rifampicin
rpoC	767158	c.3789T>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoC	767180	p.Ala1271Gln	missense_variant	0.74	rifampicin
rpoC	767191	c.3822C>G	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoC	767206	c.3837C>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	767209	c.3840T>C	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	767212	c.3843G>C	synonymous_variant	0.67	rifampicin
rpoC	767221	c.3852C>G	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoC	767230	c.3861G>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	767233	c.3864T>C	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoC	767263	c.3894T>C	synonymous_variant	0.49	rifampicin	Not assoc w R - Interim
rpoC	767264	p.Ala1299Gln	missense_variant	0.5	rifampicin
rpoC	767275	c.3906T>C	synonymous_variant	0.52	rifampicin
rpoC	767278	c.3909T>C	synonymous_variant	0.52	rifampicin
rpoC	767281	c.3912C>G	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoC	767284	c.3915C>T	synonymous_variant	0.55	rifampicin
rpoC	767288	c.3919C>T	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	775901	c.2580G>A	synonymous_variant	0.25	clofazimine
mmpL5	775901	c.2580G>A	synonymous_variant	0.25	bedaquiline
mmpL5	775909	p.Leu858Phe	missense_variant	0.28	clofazimine
mmpL5	775909	p.Leu858Phe	missense_variant	0.28	bedaquiline
mmpL5	775913	c.2568C>G	synonymous_variant	0.28	clofazimine
mmpL5	775913	c.2568C>G	synonymous_variant	0.28	bedaquiline
mmpL5	775916	c.2565T>C	synonymous_variant	0.29	clofazimine
mmpL5	775916	c.2565T>C	synonymous_variant	0.29	bedaquiline
mmpL5	775921	c.2560C>T	synonymous_variant	0.29	clofazimine
mmpL5	775921	c.2560C>T	synonymous_variant	0.29	bedaquiline
mmpL5	775937	c.2544G>C	synonymous_variant	0.29	clofazimine
mmpL5	775937	c.2544G>C	synonymous_variant	0.29	bedaquiline
mmpL5	775943	c.2538C>G	synonymous_variant	0.29	clofazimine
mmpL5	775943	c.2538C>G	synonymous_variant	0.29	bedaquiline
mmpL5	775961	c.2520C>G	synonymous_variant	0.28	clofazimine
mmpL5	775961	c.2520C>G	synonymous_variant	0.28	bedaquiline
mmpL5	775966	p.Ala839Ser	missense_variant	0.23	clofazimine
mmpL5	775966	p.Ala839Ser	missense_variant	0.23	bedaquiline
mmpL5	775981	p.Leu834Met	missense_variant	0.25	clofazimine
mmpL5	775981	p.Leu834Met	missense_variant	0.25	bedaquiline
mmpL5	775991	c.2490G>A	synonymous_variant	0.26	clofazimine
mmpL5	775991	c.2490G>A	synonymous_variant	0.26	bedaquiline
mmpL5	775997	c.2484T>C	synonymous_variant	0.26	clofazimine
mmpL5	775997	c.2484T>C	synonymous_variant	0.26	bedaquiline
mmpL5	776000	c.2479_2481delCTGinsAC	frameshift_variant&missense_variant	0.25	clofazimine	Uncertain significance
mmpL5	776000	c.2479_2481delCTGinsAC	frameshift_variant&missense_variant	0.25	bedaquiline	Uncertain significance
mmpL5	776009	c.2472A>G	synonymous_variant	0.26	clofazimine
mmpL5	776009	c.2472A>G	synonymous_variant	0.26	bedaquiline
mmpL5	776030	c.2451G>A	synonymous_variant	0.27	clofazimine
mmpL5	776030	c.2451G>A	synonymous_variant	0.27	bedaquiline
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
rpsL	781571	c.12C>T	synonymous_variant	0.55	streptomycin
rpsL	781595	c.36T>C	synonymous_variant	0.64	streptomycin
rpsL	781605	p.Ile16Val	missense_variant	0.61	streptomycin	Uncertain significance
rpsL	781608	p.Ser17Ala	missense_variant	0.62	streptomycin
rpsL	781628	c.69T>C	synonymous_variant	0.66	streptomycin	Not assoc w R - Interim
rpsL	781631	c.72G>C	synonymous_variant	0.65	streptomycin
rpsL	781649	c.90T>C	synonymous_variant	0.68	streptomycin
rpsL	781655	c.96T>C	synonymous_variant	0.69	streptomycin
rpsL	781682	c.123T>C	synonymous_variant	0.74	streptomycin
rpsL	781700	c.141G>C	synonymous_variant	0.71	streptomycin
rpsL	781703	c.144G>T	synonymous_variant	0.71	streptomycin
rpsL	781715	c.156T>C	synonymous_variant	0.7	streptomycin
rpsL	781728	c.169T>C	synonymous_variant	0.67	streptomycin
rpsL	781736	c.177T>C	synonymous_variant	0.68	streptomycin
rpsL	781742	c.183C>T	synonymous_variant	0.69	streptomycin
rpsL	781748	c.189C>G	synonymous_variant	0.71	streptomycin
rpsL	781754	c.195G>C	synonymous_variant	0.73	streptomycin
rpsL	781760	c.201T>C	synonymous_variant	0.74	streptomycin
rpsL	781772	c.213C>A	synonymous_variant	0.74	streptomycin
rpsL	781808	c.249C>T	synonymous_variant	0.78	streptomycin
rpsL	781811	c.252C>T	synonymous_variant	0.78	streptomycin
rpsL	781832	c.273T>C	synonymous_variant	0.8	streptomycin
rpsL	781838	c.279G>C	synonymous_variant	0.8	streptomycin
rpsL	781841	c.282C>G	synonymous_variant	0.78	streptomycin
rpsL	781865	c.306G>C	synonymous_variant	0.77	streptomycin
rpsL	781868	c.309T>C	synonymous_variant	0.76	streptomycin
rpsL	781871	c.312G>C	synonymous_variant	0.76	streptomycin
rpsL	781877	c.318T>C	synonymous_variant	0.76	streptomycin
rpsL	781892	c.333A>G	synonymous_variant	0.71	streptomycin
rpsL	781898	c.339A>T	synonymous_variant	0.7	streptomycin
rpsL	781916	c.357T>C	synonymous_variant	0.65	streptomycin
rpsL	781929	p.Gly124Ser	missense_variant	0.6	streptomycin	Uncertain significance
rplC	800516	c.-293G>T	upstream_gene_variant	0.67	linezolid
rplC	800537	c.-272C>T	upstream_gene_variant	0.69	linezolid
rplC	800540	c.-269T>C	upstream_gene_variant	0.7	linezolid
rplC	800546	c.-263T>G	upstream_gene_variant	0.74	linezolid
rplC	800567	c.-242A>G	upstream_gene_variant	0.78	linezolid
rplC	800582	c.-227C>G	upstream_gene_variant	0.78	linezolid
rplC	800612	c.-197A>G	upstream_gene_variant	0.82	linezolid
rplC	800618	c.-191T>C	upstream_gene_variant	0.84	linezolid
rplC	800627	c.-182C>T	upstream_gene_variant	0.84	linezolid
rplC	800648	c.-161A>T	upstream_gene_variant	0.83	linezolid
rplC	800654	c.-155T>C	upstream_gene_variant	0.82	linezolid
rplC	800693	c.-116A>G	upstream_gene_variant	0.82	linezolid
rplC	800703	c.-106T>C	upstream_gene_variant	0.83	linezolid
rplC	800715	c.-94A>C	upstream_gene_variant	0.83	linezolid
rplC	800720	c.-89T>C	upstream_gene_variant	0.83	linezolid
rplC	800723	c.-86C>G	upstream_gene_variant	0.84	linezolid
rplC	800747	c.-62C>G	upstream_gene_variant	0.83	linezolid
rplC	800771	c.-38C>T	upstream_gene_variant	0.82	linezolid
rplC	800794	c.-15A>G	upstream_gene_variant	0.81	linezolid
rplC	800796	c.-13A>G	upstream_gene_variant	0.82	linezolid
rplC	800798	c.-10_-9delGG	upstream_gene_variant	0.83	linezolid
rplC	800814	c.6A>G	synonymous_variant	0.82	linezolid
rplC	800817	c.9A>T	synonymous_variant	0.82	linezolid
rplC	800844	c.36T>C	synonymous_variant	0.81	linezolid
rplC	800865	c.57A>G	synonymous_variant	0.76	linezolid
rplC	800867	p.Ser20Asn	missense_variant	0.75	linezolid
rplC	800874	c.66A>G	synonymous_variant	0.72	linezolid
rplC	800875	c.67_69delGTAinsAT	frameshift_variant&missense_variant	0.72	linezolid
rplC	800880	c.72A>G	synonymous_variant	0.71	linezolid
rplC	800889	c.81C>G	synonymous_variant	0.7	linezolid
rplC	800892	c.84G>C	synonymous_variant	0.69	linezolid
rplC	800907	c.99C>G	synonymous_variant	0.67	linezolid
rplC	800916	c.108A>G	synonymous_variant	0.63	linezolid
rplC	800934	c.126C>G	synonymous_variant	0.54	linezolid
rplC	800937	c.129A>G	synonymous_variant	0.53	linezolid
rplC	800939	p.Arg44Gln	missense_variant	0.53	linezolid
rplC	800946	c.138T>C	synonymous_variant	0.53	linezolid
rplC	800949	c.141T>C	synonymous_variant	0.53	linezolid
rplC	800967	c.159C>G	synonymous_variant	0.46	linezolid
rplC	800970	c.162T>C	synonymous_variant	0.44	linezolid	Not assoc w R - Interim
rplC	800982	c.174C>T	synonymous_variant	0.3	linezolid
rplC	800985	c.177A>G	synonymous_variant	0.28	linezolid
rplC	801246	c.438C>T	synonymous_variant	0.27	linezolid
rplC	801249	c.441T>C	synonymous_variant	0.27	linezolid
rplC	801255	c.447C>T	synonymous_variant	0.27	linezolid
rplC	801264	c.456C>T	synonymous_variant	0.25	linezolid
rplC	801267	c.459A>T	synonymous_variant	0.26	linezolid
rplC	801270	c.462T>C	synonymous_variant	0.25	linezolid
rplC	801276	c.468G>C	synonymous_variant	0.28	linezolid
rplC	801285	c.477G>C	synonymous_variant	0.3	linezolid
rplC	801300	c.492C>G	synonymous_variant	0.43	linezolid
rplC	801309	c.501C>G	synonymous_variant	0.53	linezolid
rplC	801312	c.504G>C	synonymous_variant	0.51	linezolid
rplC	801321	c.513C>T	synonymous_variant	0.56	linezolid	Not assoc w R - Interim
rplC	801324	c.516T>C	synonymous_variant	0.59	linezolid
rplC	801339	c.531T>C	synonymous_variant	0.55	linezolid
rplC	801341	p.Leu178Gln	missense_variant	0.55	linezolid
rplC	801348	c.540T>G	synonymous_variant	0.55	linezolid
rplC	801357	c.549T>C	synonymous_variant	0.55	linezolid
rplC	801367	p.Ala187Thr	missense_variant	0.54	linezolid
rplC	801402	c.594T>C	synonymous_variant	0.63	linezolid
rplC	801405	c.597T>C	synonymous_variant	0.63	linezolid
rplC	801423	c.615G>C	synonymous_variant	0.69	linezolid
rplC	801426	c.618C>G	synonymous_variant	0.71	linezolid
rplC	801427	p.Met207Val	missense_variant	0.71	linezolid
rplC	801438	c.630T>C	synonymous_variant	0.75	linezolid
rplC	801442	p.Ile212Val	missense_variant	0.73	linezolid
fbiC	1303512	c.582T>C	synonymous_variant	0.24	clofazimine
					pretomanid
					delamanid
fbiC	1303521	c.591C>T	synonymous_variant	0.25	clofazimine
					pretomanid
					delamanid
fbiC	1303530	c.600G>A	synonymous_variant	0.25	clofazimine
					pretomanid
					delamanid
fbiC	1303534	p.Ser202Ala	missense_variant	0.24	clofazimine
					pretomanid
					delamanid
fbiC	1303539	c.609G>C	synonymous_variant	0.25	clofazimine
					pretomanid
					delamanid
fbiC	1303575	c.645G>C	synonymous_variant	0.28	clofazimine
					pretomanid
					delamanid
fbiC	1303590	c.660A>G	synonymous_variant	0.4	clofazimine
					pretomanid
					delamanid
fbiC	1303602	c.672A>G	synonymous_variant	0.42	clofazimine
					pretomanid
					delamanid
fbiC	1303605	c.675C>G	synonymous_variant	0.42	clofazimine
					pretomanid
					delamanid
fbiC	1303608	c.678G>A	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1303614	c.684C>T	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1303617	c.687C>G	synonymous_variant	0.46	clofazimine
					pretomanid
					delamanid
fbiC	1303632	c.702T>G	synonymous_variant	0.53	clofazimine
					pretomanid
					delamanid
fbiC	1303641	c.711C>T	synonymous_variant	0.52	clofazimine
					pretomanid
					delamanid
fbiC	1303650	c.720G>C	synonymous_variant	0.51	clofazimine
					pretomanid
					delamanid
fbiC	1303654	c.724C>T	synonymous_variant	0.48	clofazimine
					pretomanid
					delamanid
fbiC	1303659	c.729T>C	synonymous_variant	0.46	clofazimine
					pretomanid
					delamanid
fbiC	1303661	p.Val244Ala	missense_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1303663	c.733C>T	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1303668	c.738C>T	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1303671	c.741C>T	synonymous_variant	0.43	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid
fbiC	1303674	c.744C>G	synonymous_variant	0.45	clofazimine
					pretomanid
					delamanid
fbiC	1303681	c.751T>C	synonymous_variant	0.52	clofazimine
					pretomanid
					delamanid
fbiC	1303686	c.756C>G	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1303695	c.765T>C	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fbiC	1303704	c.774T>C	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1303708	c.778T>C	synonymous_variant	0.63	clofazimine
					pretomanid
					delamanid
fbiC	1303728	c.798G>A	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1303731	c.801A>C	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1303732	p.Ser268Ala	missense_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1303737	c.807G>A	synonymous_variant	0.64	clofazimine
					pretomanid
					delamanid
fbiC	1303746	c.816T>C	synonymous_variant	0.63	clofazimine
					pretomanid
					delamanid
fbiC	1303749	c.819G>C	synonymous_variant	0.63	clofazimine
					pretomanid
					delamanid
fbiC	1303752	c.822A>G	synonymous_variant	0.64	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1303755	c.825T>C	synonymous_variant	0.65	clofazimine
					pretomanid
					delamanid
fbiC	1303761	c.831T>C	synonymous_variant	0.68	clofazimine
					pretomanid
					delamanid
fbiC	1303785	c.855G>C	synonymous_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1303797	c.867A>G	synonymous_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1303818	c.888C>G	synonymous_variant	0.75	clofazimine
					pretomanid
					delamanid
fbiC	1303836	c.906G>C	synonymous_variant	0.76	clofazimine
					pretomanid
					delamanid
fbiC	1303845	c.915C>G	synonymous_variant	0.74	clofazimine
					pretomanid
					delamanid
fbiC	1303846	p.Phe306Val	missense_variant	0.74	clofazimine
					pretomanid
					delamanid
fbiC	1303854	c.924T>C	synonymous_variant	0.77	clofazimine
					pretomanid
					delamanid
fbiC	1303860	c.930A>C	synonymous_variant	0.77	clofazimine
					pretomanid
					delamanid
fbiC	1303884	c.954T>G	synonymous_variant	0.81	clofazimine
					pretomanid
					delamanid
fbiC	1303905	c.975G>C	synonymous_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiC	1303914	c.984C>G	synonymous_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiC	1303920	c.990C>T	synonymous_variant	0.78	clofazimine
					pretomanid
					delamanid
fbiC	1303944	c.1014G>C	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1303947	c.1017T>G	synonymous_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1303948	p.Gly340Arg	missense_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1303953	p.Asp341Glu	missense_variant	0.72	clofazimine
					pretomanid
					delamanid
fbiC	1303956	c.1026A>G	synonymous_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1303961	p.Arg344Leu	missense_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1303971	c.1041T>C	synonymous_variant	0.76	clofazimine
					pretomanid
					delamanid
fbiC	1303980	c.1050G>A	synonymous_variant	0.74	clofazimine
					pretomanid
					delamanid
fbiC	1304004	c.1074A>G	synonymous_variant	0.63	clofazimine
					pretomanid
					delamanid
fbiC	1304008	c.1078T>C	synonymous_variant	0.61	clofazimine
					pretomanid
					delamanid
fbiC	1304022	c.1092T>C	synonymous_variant	0.55	clofazimine
					pretomanid
					delamanid
fbiC	1304031	c.1101C>G	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fbiC	1304499	c.1569T>C	synonymous_variant	0.32	clofazimine
					pretomanid
					delamanid
fbiC	1304511	c.1581C>G	synonymous_variant	0.39	clofazimine
					pretomanid
					delamanid
fbiC	1304526	c.1596T>G	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304535	c.1605G>A	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304544	c.1614T>C	synonymous_variant	0.51	clofazimine
					pretomanid
					delamanid
fbiC	1304545	p.Val539Thr	missense_variant	0.51	clofazimine
					pretomanid
					delamanid
fbiC	1304553	c.1623C>T	synonymous_variant	0.53	clofazimine
					pretomanid
					delamanid
fbiC	1304559	p.Glu543Asp	missense_variant	0.56	clofazimine
					pretomanid
					delamanid
fbiC	1304565	c.1635C>G	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fbiC	1304568	c.1638T>C	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fbiC	1304580	c.1650T>C	synonymous_variant	0.59	clofazimine
					pretomanid
					delamanid
fbiC	1304613	c.1683T>C	synonymous_variant	0.7	clofazimine
					pretomanid
					delamanid
fbiC	1304634	c.1704C>G	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304640	c.1710A>C	synonymous_variant	0.68	clofazimine
					pretomanid
					delamanid
fbiC	1304646	c.1716T>C	synonymous_variant	0.69	clofazimine
					pretomanid
					delamanid
fbiC	1304658	c.1728C>G	synonymous_variant	0.64	clofazimine
					pretomanid
					delamanid
fbiC	1304661	c.1731C>T	synonymous_variant	0.61	clofazimine
					pretomanid
					delamanid
fbiC	1304670	c.1740G>C	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1304671	p.Val581Thr	missense_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1304675	p.Gly582Asp	missense_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1304691	c.1761G>C	synonymous_variant	0.56	clofazimine
					pretomanid
					delamanid
fbiC	1304694	c.1764A>C	synonymous_variant	0.56	clofazimine
					pretomanid
					delamanid
fbiC	1304703	c.1773C>G	synonymous_variant	0.55	clofazimine
					pretomanid
					delamanid
fbiC	1304711	p.Ala594Glu	missense_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304715	c.1785G>C	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304724	c.1794A>G	synonymous_variant	0.47	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304727	c.1797A>G	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fbiC	1304742	c.1812T>C	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1304757	c.1827A>G	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304778	c.1848T>C	synonymous_variant	0.45	clofazimine
					pretomanid
					delamanid
fbiC	1304784	c.1854T>C	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304787	c.1857T>G	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304808	c.1878C>G	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304811	c.1881C>G	synonymous_variant	0.49	clofazimine
					pretomanid
					delamanid
fbiC	1304817	c.1887T>C	synonymous_variant	0.61	clofazimine
					pretomanid
					delamanid
fbiC	1304829	c.1899T>C	synonymous_variant	0.67	clofazimine
					pretomanid
					delamanid
fbiC	1304832	c.1902C>T	synonymous_variant	0.67	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304856	c.1926C>G	synonymous_variant	0.68	clofazimine
					pretomanid
					delamanid
fbiC	1304869	c.1939C>T	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304875	p.Ile649Val	missense_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1304883	p.Glu651Asp	missense_variant	0.74	clofazimine
					pretomanid
					delamanid
fbiC	1304891	p.Ile654Thr	missense_variant	0.74	clofazimine
					pretomanid
					delamanid
fbiC	1304893	p.Gly655Ser	missense_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1304907	c.1977C>G	synonymous_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1304910	c.1980G>C	synonymous_variant	0.72	clofazimine
					pretomanid
					delamanid
fbiC	1304916	c.1986T>C	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304928	c.1998T>C	synonymous_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1304937	c.2007G>C	synonymous_variant	0.73	clofazimine
					pretomanid
					delamanid
fbiC	1304958	c.2028T>G	synonymous_variant	0.7	clofazimine
					pretomanid
					delamanid
fbiC	1304983	c.2053C>T	synonymous_variant	0.59	clofazimine
					pretomanid
					delamanid
fbiC	1304994	c.2064A>G	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fbiC	1304995	p.Leu689Met	missense_variant	0.56	clofazimine
					pretomanid
					delamanid
fbiC	1305006	c.2076A>G	synonymous_variant	0.53	clofazimine
					pretomanid
					delamanid
fbiC	1305012	c.2082G>C	synonymous_variant	0.55	clofazimine
					pretomanid
					delamanid
fbiC	1305015	c.2085G>C	synonymous_variant	0.44	clofazimine
					pretomanid
					delamanid
fbiC	1305021	c.2091C>G	synonymous_variant	0.4	clofazimine
					pretomanid
					delamanid
fbiC	1305030	c.2100G>C	synonymous_variant	0.34	clofazimine
					pretomanid
					delamanid
fbiC	1305033	c.2103T>G	synonymous_variant	0.34	clofazimine
					pretomanid
					delamanid
fbiC	1305150	c.2220C>G	synonymous_variant	0.28	clofazimine
					pretomanid
					delamanid
fbiC	1305173	p.Asn748Ser	missense_variant	0.31	clofazimine
					pretomanid
					delamanid
fbiC	1305177	c.2247A>G	synonymous_variant	0.3	clofazimine
					pretomanid
					delamanid
fbiC	1305181	c.2251T>C	synonymous_variant	0.3	clofazimine
					pretomanid
					delamanid
fbiC	1305186	c.2256C>T	synonymous_variant	0.31	clofazimine
					pretomanid
					delamanid
fbiC	1305195	c.2265T>C	synonymous_variant	0.3	clofazimine
					pretomanid
					delamanid
fbiC	1305201	c.2271G>C	synonymous_variant	0.33	clofazimine
					pretomanid
					delamanid
fbiC	1305204	c.2274C>G	synonymous_variant	0.37	clofazimine
					pretomanid
					delamanid
fbiC	1305210	c.2280G>A	synonymous_variant	0.42	clofazimine
					pretomanid
					delamanid
fbiC	1305215	p.Ser762Thr	missense_variant	0.47	clofazimine
					pretomanid
					delamanid
fbiC	1305231	c.2301C>A	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fbiC	1305234	c.2304G>C	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fbiC	1305240	c.2310T>C	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fbiC	1305243	c.2313T>G	synonymous_variant	0.5	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid
fbiC	1305244	c.2314T>C	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fbiC	1305252	c.2322G>A	synonymous_variant	0.56	clofazimine
					pretomanid
					delamanid
fbiC	1305276	c.2346G>C	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fbiC	1305279	p.His783Gln	missense_variant	0.57	clofazimine
					pretomanid
					delamanid
fbiC	1305282	c.2352T>C	synonymous_variant	0.57	clofazimine
					pretomanid
					delamanid
fbiC	1305297	c.2367G>C	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1305300	c.2370A>G	synonymous_variant	0.56	clofazimine
					pretomanid
					delamanid
fbiC	1305303	c.2373T>C	synonymous_variant	0.55	clofazimine
					pretomanid
					delamanid
fbiC	1305306	c.2376A>T	synonymous_variant	0.53	clofazimine
					pretomanid
					delamanid
fbiC	1305309	c.2379G>C	synonymous_variant	0.52	clofazimine
					pretomanid
					delamanid
fbiC	1305310	p.Arg794Glu	missense_variant	0.52	clofazimine
					pretomanid
					delamanid
fbiC	1305318	c.2388C>G	synonymous_variant	0.54	clofazimine
					pretomanid
					delamanid
fbiC	1305336	c.2406T>C	synonymous_variant	0.59	clofazimine
					pretomanid
					delamanid
fbiC	1305372	c.2442G>A	synonymous_variant	0.49	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid
fbiC	1305384	c.2454G>C	synonymous_variant	0.47	clofazimine
					pretomanid
					delamanid
fbiC	1305396	c.2466C>G	synonymous_variant	0.42	clofazimine
					pretomanid
					delamanid
fbiC	1305405	c.2475A>G	synonymous_variant	0.4	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid
sigE	1364793	c.381C>T	synonymous_variant	0.21	pyrazinamide
sigE	1364802	c.390C>A	synonymous_variant	0.29	pyrazinamide
sigE	1364805	c.393C>G	synonymous_variant	0.31	pyrazinamide
sigE	1364814	c.402C>G	synonymous_variant	0.4	pyrazinamide
sigE	1364820	c.408A>G	synonymous_variant	0.4	pyrazinamide
sigE	1364839	c.427_429delTTGinsCC	frameshift_variant&missense_variant	0.38	pyrazinamide	Uncertain significance
sigE	1364847	c.435G>C	synonymous_variant	0.36	pyrazinamide
sigE	1364856	c.444C>G	synonymous_variant	0.38	pyrazinamide
sigE	1364862	c.450C>A	synonymous_variant	0.37	pyrazinamide
sigE	1364865	c.453G>C	synonymous_variant	0.37	pyrazinamide
sigE	1364868	c.456T>G	synonymous_variant	0.37	pyrazinamide
sigE	1364887	c.475_477delTTAinsCG	frameshift_variant&missense_variant	0.35	pyrazinamide	Uncertain significance
sigE	1364898	c.486C>T	synonymous_variant	0.35	pyrazinamide
sigE	1364904	p.Asp164Glu	missense_variant	0.34	pyrazinamide
sigE	1364919	c.507T>C	synonymous_variant	0.34	pyrazinamide
sigE	1364943	c.531C>T	synonymous_variant	0.25	pyrazinamide
sigE	1365000	c.588G>A	synonymous_variant	0.29	pyrazinamide	Not assoc w R - Interim
sigE	1365006	c.594T>C	synonymous_variant	0.29	pyrazinamide
sigE	1365009	c.597C>G	synonymous_variant	0.29	pyrazinamide
sigE	1365012	c.600G>C	synonymous_variant	0.3	pyrazinamide
sigE	1365015	c.603G>C	synonymous_variant	0.3	pyrazinamide
sigE	1365018	c.606G>C	synonymous_variant	0.3	pyrazinamide
sigE	1365024	c.612T>C	synonymous_variant	0.31	pyrazinamide
sigE	1365033	c.621G>A	synonymous_variant	0.32	pyrazinamide
sigE	1365036	c.624T>C	synonymous_variant	0.32	pyrazinamide
sigE	1365042	c.630G>C	synonymous_variant	0.33	pyrazinamide
sigE	1365057	c.645C>T	synonymous_variant	0.33	pyrazinamide
sigE	1365063	c.651A>C	synonymous_variant	0.35	pyrazinamide
sigE	1365084	c.672G>C	synonymous_variant	0.34	pyrazinamide
sigE	1365087	c.675A>C	synonymous_variant	0.35	pyrazinamide
sigE	1365090	c.678T>C	synonymous_variant	0.34	pyrazinamide
sigE	1365096	c.684G>C	synonymous_variant	0.33	pyrazinamide
sigE	1365099	c.687A>C	synonymous_variant	0.33	pyrazinamide
sigE	1365114	c.702G>A	synonymous_variant	0.33	pyrazinamide
sigE	1365117	c.705A>C	synonymous_variant	0.33	pyrazinamide
sigE	1365118	c.706C>T	synonymous_variant	0.33	pyrazinamide	Not assoc w R - Interim
atpE	1460816	c.-229T>C	upstream_gene_variant	0.4	bedaquiline
atpE	1460831	c.-214T>C	upstream_gene_variant	0.39	bedaquiline
atpE	1460840	c.-205A>G	upstream_gene_variant	0.36	bedaquiline
atpE	1460852	c.-193C>G	upstream_gene_variant	0.36	bedaquiline
atpE	1460855	c.-190T>C	upstream_gene_variant	0.35	bedaquiline
atpE	1460858	c.-187C>G	upstream_gene_variant	0.37	bedaquiline
atpE	1460861	c.-184C>G	upstream_gene_variant	0.36	bedaquiline
atpE	1460882	c.-163T>C	upstream_gene_variant	0.33	bedaquiline
atpE	1460894	c.-151A>G	upstream_gene_variant	0.29	bedaquiline
atpE	1460897	c.-148A>C	upstream_gene_variant	0.28	bedaquiline
atpE	1460900	c.-145T>C	upstream_gene_variant	0.28	bedaquiline
atpE	1460915	c.-130C>G	upstream_gene_variant	0.27	bedaquiline
atpE	1460918	c.-127A>G	upstream_gene_variant	0.26	bedaquiline
atpE	1461089	c.45G>C	synonymous_variant	0.45	bedaquiline
atpE	1461097	p.Ala18Gly	missense_variant	0.51	bedaquiline
atpE	1461101	c.57T>C	synonymous_variant	0.52	bedaquiline
atpE	1461107	c.63C>G	synonymous_variant	0.58	bedaquiline
atpE	1461113	c.69C>T	synonymous_variant	0.6	bedaquiline
atpE	1461132	p.Val30Ile	missense_variant	0.68	bedaquiline
atpE	1461149	c.105T>G	synonymous_variant	0.71	bedaquiline
atpE	1461150	c.106_108delATCinsGT	frameshift_variant&missense_variant	0.71	bedaquiline
atpE	1461158	c.114T>G	synonymous_variant	0.72	bedaquiline
atpE	1461159	p.Val39Ile	missense_variant	0.71	bedaquiline	Uncertain significance
atpE	1461170	c.126A>G	synonymous_variant	0.72	bedaquiline
atpE	1461185	c.141G>T	synonymous_variant	0.72	bedaquiline
atpE	1461197	c.153A>G	synonymous_variant	0.74	bedaquiline
atpE	1461219	c.175T>C	synonymous_variant	0.74	bedaquiline
atpE	1461233	c.189A>C	synonymous_variant	0.7	bedaquiline
atpE	1461251	c.207G>C	synonymous_variant	0.62	bedaquiline
atpE	1461254	c.210T>C	synonymous_variant	0.59	bedaquiline
atpE	1461275	c.231T>A	synonymous_variant	0.37	bedaquiline
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1471923	n.78T>C	non_coding_transcript_exon_variant	0.55	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471925	n.80T>C	non_coding_transcript_exon_variant	0.56	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471932	n.87A>G	non_coding_transcript_exon_variant	0.54	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1471934	n.89A>G	non_coding_transcript_exon_variant	0.53	streptomycin	Uncertain significance
					kanamycin
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471969	n.124T>C	non_coding_transcript_exon_variant	0.55	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471970	n.125G>A	non_coding_transcript_exon_variant	0.55	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472061	n.216A>T	non_coding_transcript_exon_variant	0.29	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472075	n.230A>G	non_coding_transcript_exon_variant	0.33	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472108	n.263C>T	non_coding_transcript_exon_variant	0.46	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472300	n.455C>T	non_coding_transcript_exon_variant	0.81	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472969	n.1124A>G	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472970	n.1125C>G	non_coding_transcript_exon_variant	0.78	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472977	n.1132G>C	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472978	n.1133T>C	non_coding_transcript_exon_variant	0.77	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473105	n.1260G>A	non_coding_transcript_exon_variant	0.84	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473123	n.1278delAinsTT	non_coding_transcript_exon_variant	0.84	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.86	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.86	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	0.8	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1473668	n.11C>T	non_coding_transcript_exon_variant	0.42	capreomycin	Uncertain significance
rrl	1473668	n.11C>T	non_coding_transcript_exon_variant	0.42	linezolid
rrl	1473756	n.99G>A	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1473756	n.99G>A	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	0.45	capreomycin
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	0.45	linezolid
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	0.22	linezolid	Uncertain significance
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	0.94	capreomycin	Not assoc w R
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	0.94	linezolid	Not assoc w R
rrl	1474093	n.436G>T	non_coding_transcript_exon_variant	0.33	capreomycin
rrl	1474093	n.436G>T	non_coding_transcript_exon_variant	0.33	linezolid
rrl	1474099	n.442G>A	non_coding_transcript_exon_variant	0.36	capreomycin
rrl	1474099	n.442G>A	non_coding_transcript_exon_variant	0.36	linezolid
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	0.41	capreomycin
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	0.41	linezolid
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	0.66	linezolid	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1474291	n.635_649delTTCCTCTCCGGAGGA	non_coding_transcript_exon_variant	0.64	capreomycin
rrl	1474291	n.635_649delTTCCTCTCCGGAGGA	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.61	capreomycin	Uncertain significance
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.61	linezolid	Uncertain significance
rrl	1474310	n.653T>G	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1474310	n.653T>G	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1474356	n.699T>C	non_coding_transcript_exon_variant	0.72	capreomycin	Uncertain significance
rrl	1474356	n.699T>C	non_coding_transcript_exon_variant	0.72	linezolid
rrl	1474362	n.705A>G	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1474362	n.705A>G	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1474376	n.719T>C	non_coding_transcript_exon_variant	0.74	capreomycin
rrl	1474376	n.719T>C	non_coding_transcript_exon_variant	0.74	linezolid
rrl	1474409	n.756_766delACCCACACGCG	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1474409	n.756_766delACCCACACGCG	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1474427	n.770A>C	non_coding_transcript_exon_variant	0.66	capreomycin
rrl	1474427	n.770A>C	non_coding_transcript_exon_variant	0.66	linezolid
rrl	1474429	n.772G>C	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1474429	n.772G>C	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1474431	n.774_775delGCinsTTTGGG	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1474431	n.774_775delGCinsTTTGGG	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1474435	n.780_783delGAAT	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1474435	n.780_783delGAAT	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1474639	n.982G>A	non_coding_transcript_exon_variant	0.87	capreomycin	Uncertain significance
rrl	1474639	n.982G>A	non_coding_transcript_exon_variant	0.87	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1474823	n.1166C>T	non_coding_transcript_exon_variant	0.81	capreomycin
rrl	1474823	n.1166C>T	non_coding_transcript_exon_variant	0.81	linezolid
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1474904	n.1247G>A	non_coding_transcript_exon_variant	0.6	capreomycin
rrl	1474904	n.1247G>A	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1475006	n.1349A>T	non_coding_transcript_exon_variant	0.48	capreomycin
rrl	1475006	n.1349A>T	non_coding_transcript_exon_variant	0.48	linezolid
rrl	1475028	n.1371G>A	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1475028	n.1371G>A	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1475061	n.1404C>T	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1475061	n.1404C>T	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1475088	n.1431A>T	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1475088	n.1431A>T	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1475199	n.1542G>A	non_coding_transcript_exon_variant	0.84	capreomycin
rrl	1475199	n.1542G>A	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1475206	n.1549C>T	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1475206	n.1549C>T	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1475209	n.1552G>C	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1475209	n.1552G>C	non_coding_transcript_exon_variant	0.84	linezolid
rrl	1475213	n.1556C>T	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1475213	n.1556C>T	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1475249	n.1592T>C	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1475249	n.1592T>C	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1475252	n.1595C>T	non_coding_transcript_exon_variant	0.85	capreomycin
rrl	1475252	n.1595C>T	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1475266	n.1609T>C	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1475266	n.1609T>C	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1475267	n.1610G>A	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1475267	n.1610G>A	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1475275	n.1618C>T	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1475275	n.1618C>T	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1475276	n.1619T>C	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1475276	n.1619T>C	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1475291	n.1634A>C	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1475291	n.1634A>C	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.71	capreomycin
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.71	linezolid
rrl	1475402	n.1745C>T	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1475402	n.1745C>T	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.68	linezolid
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	0.74	capreomycin	Uncertain significance
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	0.74	linezolid	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.77	capreomycin	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.77	linezolid
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1475573	n.1916G>A	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1475573	n.1916G>A	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	0.81	capreomycin	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	0.81	linezolid
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1475659	n.2002G>T	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1475659	n.2002G>T	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1475761	n.2104_2106delCGCinsGT	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1475761	n.2104_2106delCGCinsGT	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1475765	n.2111delG	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1475765	n.2111delG	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.78	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1476031	n.2374C>T	non_coding_transcript_exon_variant	0.65	capreomycin
rrl	1476031	n.2374C>T	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1476032	n.2375C>A	non_coding_transcript_exon_variant	0.66	capreomycin
rrl	1476032	n.2375C>A	non_coding_transcript_exon_variant	0.66	linezolid
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	0.66	linezolid
rrl	1476034	n.2377C>A	non_coding_transcript_exon_variant	0.65	capreomycin	Uncertain significance
rrl	1476034	n.2377C>A	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1476047	n.2390G>T	non_coding_transcript_exon_variant	0.66	capreomycin
rrl	1476047	n.2390G>T	non_coding_transcript_exon_variant	0.66	linezolid
rrl	1476048	n.2391G>A	non_coding_transcript_exon_variant	0.66	capreomycin
rrl	1476048	n.2391G>A	non_coding_transcript_exon_variant	0.66	linezolid
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.68	capreomycin	Uncertain significance
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.68	linezolid	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	0.71	linezolid	Uncertain significance
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	0.73	capreomycin
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	0.73	linezolid
rrl	1476095	n.2438C>G	non_coding_transcript_exon_variant	0.7	capreomycin
rrl	1476095	n.2438C>G	non_coding_transcript_exon_variant	0.7	linezolid
rrl	1476103	n.2446C>G	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1476103	n.2446C>G	non_coding_transcript_exon_variant	0.66	linezolid
rrl	1476105	n.2448G>A	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1476105	n.2448G>A	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1476106	n.2449A>T	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1476106	n.2449A>T	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1476110	n.2453G>C	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1476110	n.2453G>C	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.65	capreomycin	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.65	linezolid	Uncertain significance
rrl	1476117	n.2460G>C	non_coding_transcript_exon_variant	0.69	capreomycin
rrl	1476117	n.2460G>C	non_coding_transcript_exon_variant	0.69	linezolid
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1476131	n.2474C>T	non_coding_transcript_exon_variant	0.66	linezolid	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.54	capreomycin	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.54	linezolid	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.53	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.53	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1476297	n.2640C>T	non_coding_transcript_exon_variant	0.58	capreomycin	Uncertain significance
rrl	1476297	n.2640C>T	non_coding_transcript_exon_variant	0.58	linezolid	Uncertain significance
rrl	1476299	n.2642C>T	non_coding_transcript_exon_variant	0.57	capreomycin	Uncertain significance
rrl	1476299	n.2642C>T	non_coding_transcript_exon_variant	0.57	linezolid	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.78	capreomycin	Not assoc w R
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1476594	n.2937C>T	non_coding_transcript_exon_variant	0.76	capreomycin	Not assoc w R
rrl	1476594	n.2937C>T	non_coding_transcript_exon_variant	0.76	linezolid	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.77	capreomycin	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.77	linezolid
rrl	1476603	n.2946G>A	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1476603	n.2946G>A	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	0.74	capreomycin	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	0.74	linezolid	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.71	linezolid	Uncertain significance
rrl	1476689	n.3032A>T	non_coding_transcript_exon_variant	0.32	capreomycin
rrl	1476689	n.3032A>T	non_coding_transcript_exon_variant	0.32	linezolid
rrl	1476690	n.3033C>T	non_coding_transcript_exon_variant	0.31	capreomycin	Uncertain significance
rrl	1476690	n.3033C>T	non_coding_transcript_exon_variant	0.31	linezolid
rrl	1476693	n.3036G>A	non_coding_transcript_exon_variant	0.3	capreomycin
rrl	1476693	n.3036G>A	non_coding_transcript_exon_variant	0.3	linezolid
rrl	1476695	n.3038T>A	non_coding_transcript_exon_variant	0.3	capreomycin
rrl	1476695	n.3038T>A	non_coding_transcript_exon_variant	0.3	linezolid
fabG1	1673890	p.Ala151Ser	missense_variant	0.27	ethionamide
fabG1	1673890	p.Ala151Ser	missense_variant	0.27	isoniazid
inhA	1673901	c.-301A>G	upstream_gene_variant	0.27	ethionamide
inhA	1673901	c.-301A>G	upstream_gene_variant	0.27	isoniazid
fabG1	1673905	p.Ser156Ala	missense_variant	0.27	ethionamide
fabG1	1673905	p.Ser156Ala	missense_variant	0.27	isoniazid
inhA	1673916	c.-286A>C	upstream_gene_variant	0.27	ethionamide
inhA	1673916	c.-286A>C	upstream_gene_variant	0.27	isoniazid
fabG1	1673917	p.Val160Leu	missense_variant	0.27	ethionamide
fabG1	1673917	p.Val160Leu	missense_variant	0.27	isoniazid
inhA	1673922	c.-280T>C	upstream_gene_variant	0.27	ethionamide
inhA	1673922	c.-280T>C	upstream_gene_variant	0.27	isoniazid
fabG1	1673941	p.Ala168Ser	missense_variant	0.35	ethionamide
fabG1	1673941	p.Ala168Ser	missense_variant	0.35	isoniazid
inhA	1673955	c.-247G>C	upstream_gene_variant	0.42	ethionamide
inhA	1673955	c.-247G>C	upstream_gene_variant	0.42	isoniazid
inhA	1673961	c.-241A>C	upstream_gene_variant	0.44	ethionamide
inhA	1673961	c.-241A>C	upstream_gene_variant	0.44	isoniazid
inhA	1673985	c.-217C>G	upstream_gene_variant	0.52	ethionamide
inhA	1673985	c.-217C>G	upstream_gene_variant	0.52	isoniazid
fabG1	1674006	p.Asp189Glu	missense_variant	0.52	ethionamide
fabG1	1674006	p.Asp189Glu	missense_variant	0.52	isoniazid
inhA	1674015	c.-187C>T	upstream_gene_variant	0.51	ethionamide
inhA	1674015	c.-187C>T	upstream_gene_variant	0.51	isoniazid	Uncertain significance
inhA	1674018	c.-184G>C	upstream_gene_variant	0.49	ethionamide
inhA	1674018	c.-184G>C	upstream_gene_variant	0.49	isoniazid
inhA	1674021	c.-181G>C	upstream_gene_variant	0.5	ethionamide
inhA	1674021	c.-181G>C	upstream_gene_variant	0.5	isoniazid
inhA	1674024	c.-178T>C	upstream_gene_variant	0.49	ethionamide
inhA	1674024	c.-178T>C	upstream_gene_variant	0.49	isoniazid
inhA	1674033	c.-169T>C	upstream_gene_variant	0.49	ethionamide
inhA	1674033	c.-169T>C	upstream_gene_variant	0.49	isoniazid
fabG1	1674037	p.Gln200Ala	missense_variant	0.49	ethionamide
fabG1	1674037	p.Gln200Ala	missense_variant	0.49	isoniazid
inhA	1674042	c.-160G>T	upstream_gene_variant	0.48	ethionamide
inhA	1674042	c.-160G>T	upstream_gene_variant	0.48	isoniazid
fabG1	1674049	c.610_612delCAAinsGC	frameshift_variant&missense_variant	0.48	ethionamide
fabG1	1674049	c.610_612delCAAinsGC	frameshift_variant&missense_variant	0.48	isoniazid
inhA	1674054	c.-148T>C	upstream_gene_variant	0.48	ethionamide
inhA	1674054	c.-148T>C	upstream_gene_variant	0.48	isoniazid
inhA	1674060	c.-142A>G	upstream_gene_variant	0.47	ethionamide
inhA	1674060	c.-142A>G	upstream_gene_variant	0.47	isoniazid
inhA	1674063	c.-139G>C	upstream_gene_variant	0.47	ethionamide
inhA	1674063	c.-139G>C	upstream_gene_variant	0.47	isoniazid
fabG1	1674079	p.Pro214Ala	missense_variant	0.42	ethionamide
fabG1	1674079	p.Pro214Ala	missense_variant	0.42	isoniazid
inhA	1674114	c.-88T>A	upstream_gene_variant	0.24	ethionamide	Uncertain significance
inhA	1674114	c.-88T>A	upstream_gene_variant	0.24	isoniazid	Uncertain significance
rpsA	1833515	c.-27_-24delCAACinsAAA	upstream_gene_variant	0.3	pyrazinamide
rpsA	1833532	c.-10A>C	upstream_gene_variant	0.55	pyrazinamide
rpsA	1833554	p.Thr5Ala	missense_variant	0.64	pyrazinamide	Uncertain significance
rpsA	1833568	c.27G>C	synonymous_variant	0.71	pyrazinamide	Not assoc w R - Interim
rpsA	1833589	c.48A>T	synonymous_variant	0.72	pyrazinamide
rpsA	1833595	c.54T>C	synonymous_variant	0.75	pyrazinamide
rpsA	1833661	c.120A>G	synonymous_variant	0.85	pyrazinamide
rpsA	1833667	c.126C>G	synonymous_variant	0.85	pyrazinamide
rpsA	1833721	c.180A>G	synonymous_variant	0.83	pyrazinamide
rpsA	1833724	c.183C>G	synonymous_variant	0.82	pyrazinamide
rpsA	1833727	c.186G>C	synonymous_variant	0.82	pyrazinamide
rpsA	1833742	c.201A>G	synonymous_variant	0.83	pyrazinamide
rpsA	1833745	c.204G>C	synonymous_variant	0.83	pyrazinamide
rpsA	1833748	c.207C>G	synonymous_variant	0.83	pyrazinamide
rpsA	1833787	c.246C>G	synonymous_variant	0.83	pyrazinamide
rpsA	1833790	c.249T>C	synonymous_variant	0.81	pyrazinamide
rpsA	1833802	c.261A>G	synonymous_variant	0.82	pyrazinamide
rpsA	1833811	c.270G>T	synonymous_variant	0.8	pyrazinamide
rpsA	1833838	c.297G>C	synonymous_variant	0.82	pyrazinamide
rpsA	1833841	c.300C>G	synonymous_variant	0.82	pyrazinamide
rpsA	1833847	c.306C>G	synonymous_variant	0.82	pyrazinamide
rpsA	1833856	c.315A>G	synonymous_variant	0.83	pyrazinamide
rpsA	1833874	c.333T>C	synonymous_variant	0.83	pyrazinamide
rpsA	1833928	c.387G>C	synonymous_variant	0.82	pyrazinamide
rpsA	1833940	c.399C>G	synonymous_variant	0.83	pyrazinamide
rpsA	1833971	c.430C>T	synonymous_variant	0.81	pyrazinamide
rpsA	1833979	c.438T>C	synonymous_variant	0.82	pyrazinamide
rpsA	1834000	c.459G>C	synonymous_variant	0.84	pyrazinamide
rpsA	1834021	c.480C>T	synonymous_variant	0.83	pyrazinamide
rpsA	1834030	c.489C>G	synonymous_variant	0.82	pyrazinamide
rpsA	1834099	c.558C>G	synonymous_variant	0.79	pyrazinamide
rpsA	1834102	c.561T>C	synonymous_variant	0.78	pyrazinamide
rpsA	1834105	c.564C>G	synonymous_variant	0.79	pyrazinamide
rpsA	1834108	c.567C>G	synonymous_variant	0.81	pyrazinamide
rpsA	1834123	c.582C>G	synonymous_variant	0.81	pyrazinamide
rpsA	1834150	c.609G>C	synonymous_variant	0.71	pyrazinamide
rpsA	1834153	c.612T>C	synonymous_variant	0.7	pyrazinamide
rpsA	1834154	c.613_615delAACinsCG	frameshift_variant&missense_variant	0.7	pyrazinamide	Uncertain significance
rpsA	1834157	c.616T>C	synonymous_variant	0.7	pyrazinamide
rpsA	1834162	c.621A>G	synonymous_variant	0.71	pyrazinamide	Not assoc w R - Interim
rpsA	1834165	c.624A>G	synonymous_variant	0.7	pyrazinamide
rpsA	1834169	p.Thr210Ala	missense_variant	0.72	pyrazinamide	Uncertain significance
rpsA	1834177	c.636A>C	synonymous_variant	0.74	pyrazinamide	Not assoc w R - Interim
rpsA	1834189	c.648G>C	synonymous_variant	0.77	pyrazinamide
rpsA	1834195	c.654G>C	synonymous_variant	0.77	pyrazinamide
rpsA	1834210	c.669C>T	synonymous_variant	0.75	pyrazinamide
rpsA	1834222	c.681T>C	synonymous_variant	0.74	pyrazinamide
rpsA	1834231	c.690T>C	synonymous_variant	0.72	pyrazinamide
rpsA	1834234	c.693G>C	synonymous_variant	0.71	pyrazinamide
rpsA	1834249	c.708T>C	synonymous_variant	0.66	pyrazinamide
rpsA	1834261	c.720A>G	synonymous_variant	0.58	pyrazinamide	Not assoc w R - Interim
rpsA	1834262	c.721_723delTCGinsAGC	synonymous_variant	0.58	pyrazinamide
rpsA	1834303	c.762T>C	synonymous_variant	0.55	pyrazinamide
rpsA	1834306	c.765T>C	synonymous_variant	0.56	pyrazinamide
rpsA	1834333	c.792C>T	synonymous_variant	0.51	pyrazinamide
rpsA	1834348	c.807T>C	synonymous_variant	0.25	pyrazinamide	Not assoc w R - Interim
rpsA	1834396	c.855G>C	synonymous_variant	0.35	pyrazinamide
rpsA	1834411	c.870T>C	synonymous_variant	0.43	pyrazinamide
rpsA	1834417	c.876G>C	synonymous_variant	0.44	pyrazinamide
rpsA	1834423	c.882G>C	synonymous_variant	0.46	pyrazinamide
rpsA	1834435	c.894G>C	synonymous_variant	0.54	pyrazinamide
rpsA	1834451	c.910T>C	synonymous_variant	0.6	pyrazinamide
rpsA	1834465	c.924T>C	synonymous_variant	0.63	pyrazinamide
rpsA	1834468	c.927A>G	synonymous_variant	0.63	pyrazinamide
rpsA	1834489	c.948T>C	synonymous_variant	0.63	pyrazinamide
rpsA	1834528	c.987T>C	synonymous_variant	0.63	pyrazinamide
rpsA	1834540	c.999G>C	synonymous_variant	0.63	pyrazinamide
rpsA	1834546	c.1005T>C	synonymous_variant	0.6	pyrazinamide
rpsA	1834606	c.1065C>G	synonymous_variant	0.28	pyrazinamide
rpsA	1834609	c.1068T>C	synonymous_variant	0.29	pyrazinamide
rpsA	1834618	c.1077G>C	synonymous_variant	0.32	pyrazinamide
rpsA	1834633	c.1092A>G	synonymous_variant	0.36	pyrazinamide
rpsA	1834639	c.1098T>C	synonymous_variant	0.38	pyrazinamide
rpsA	1834654	p.Glu371Asp	missense_variant	0.46	pyrazinamide
rpsA	1834690	c.1149T>C	synonymous_variant	0.46	pyrazinamide
rpsA	1834732	c.1191T>C	synonymous_variant	0.41	pyrazinamide
rpsA	1834733	p.Ala398Ser	missense_variant	0.43	pyrazinamide
rpsA	1834738	c.1197A>G	synonymous_variant	0.43	pyrazinamide
rpsA	1834753	c.1212T>C	synonymous_variant	0.42	pyrazinamide
rpsA	1834765	p.Glu408Asp	missense_variant	0.33	pyrazinamide
rpsA	1834775	p.Ala412Thr	missense_variant	0.26	pyrazinamide
tsnR	1853361	c.-245T>C	upstream_gene_variant	0.66	linezolid
tsnR	1853370	c.-236_-234delGCAinsTG	upstream_gene_variant	0.65	linezolid
tsnR	1853387	c.-219T>G	upstream_gene_variant	0.63	linezolid
tsnR	1853394	c.-212_-211delCTinsGC	upstream_gene_variant	0.61	linezolid
tsnR	1853420	c.-186T>G	upstream_gene_variant	0.6	linezolid
tsnR	1853429	c.-177G>C	upstream_gene_variant	0.55	linezolid
tsnR	1853432	c.-174G>C	upstream_gene_variant	0.56	linezolid
tsnR	1853447	c.-159C>G	upstream_gene_variant	0.49	linezolid
tsnR	1853459	c.-147G>C	upstream_gene_variant	0.38	linezolid
tsnR	1853462	c.-144A>G	upstream_gene_variant	0.35	linezolid
tsnR	1853468	c.-138C>G	upstream_gene_variant	0.33	linezolid
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
bacA	2063349	c.1380G>A	synonymous_variant	0.21	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064870	c.-142A>G	upstream_gene_variant	0.26	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064873	c.-145A>T	upstream_gene_variant	0.31	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064882	c.-154C>G	upstream_gene_variant	0.42	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064892	c.-164A>G	upstream_gene_variant	0.46	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064897	c.-169C>G	upstream_gene_variant	0.46	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064903	c.-175G>A	upstream_gene_variant	0.49	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064912	c.-184A>G	upstream_gene_variant	0.52	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064915	c.-187G>C	upstream_gene_variant	0.53	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064933	c.-205A>G	upstream_gene_variant	0.61	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064936	c.-208C>G	upstream_gene_variant	0.63	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064942	c.-214G>A	upstream_gene_variant	0.64	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064948	c.-220G>C	upstream_gene_variant	0.66	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064972	c.-244T>C	upstream_gene_variant	0.7	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064978	c.-250G>C	upstream_gene_variant	0.71	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064979	c.-251C>T	upstream_gene_variant	0.7	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064984	c.-256A>G	upstream_gene_variant	0.7	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064993	c.-265T>C	upstream_gene_variant	0.72	streptomycin
					kanamycin
					capreomycin
					amikacin
ndh	2102131	c.910_912delCAAinsAG	frameshift_variant&synonymous_variant	0.28	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Uncertain significance
ndh	2102140	c.903C>T	synonymous_variant	0.27	ethionamide	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
ndh	2102155	c.888G>A	synonymous_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102158	c.885T>C	synonymous_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102162	p.Arg294Thr	missense_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102164	c.879A>G	synonymous_variant	0.26	ethionamide
					delamanid
					isoniazid
ndh	2102167	c.876A>G	synonymous_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102170	p.Glu291Asp	missense_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102176	c.867T>C	synonymous_variant	0.28	ethionamide
					delamanid
					isoniazid
ndh	2102182	c.859_861delAGGinsCC	frameshift_variant&missense_variant	0.27	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Uncertain significance
ndh	2102190	c.853T>C	synonymous_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102192	p.Arg284Pro	missense_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102194	c.849T>C	synonymous_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102206	c.837G>C	synonymous_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102212	c.831G>C	synonymous_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102218	c.825C>A	synonymous_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102227	c.816C>T	synonymous_variant	0.25	ethionamide
					delamanid
					isoniazid
ndh	2102233	c.810G>A	synonymous_variant	0.25	ethionamide	Not assoc w R - Interim
					delamanid
					isoniazid	Not assoc w R - Interim
ndh	2102302	c.741G>C	synonymous_variant	0.26	ethionamide
					delamanid
					isoniazid
ndh	2102305	c.738T>C	synonymous_variant	0.25	ethionamide
					delamanid
					isoniazid
ndh	2102314	c.729C>T	synonymous_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102317	c.726A>G	synonymous_variant	0.27	ethionamide
					delamanid
					isoniazid
ndh	2102328	p.Leu239Met	missense_variant	0.26	ethionamide
					delamanid
					isoniazid
ndh	2102332	c.709_711delCAGinsGA	frameshift_variant&missense_variant	0.25	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Uncertain significance
ndh	2102337	c.706T>C	synonymous_variant	0.26	ethionamide	Not assoc w R - Interim
					delamanid
					isoniazid
ndh	2102342	p.Ala234Asp	missense_variant	0.26	ethionamide
					delamanid
					isoniazid
ndh	2102356	c.687T>C	synonymous_variant	0.25	ethionamide
					delamanid
					isoniazid
ndh	2102366	p.Ala226Glu	missense_variant	0.25	ethionamide
					delamanid
					isoniazid	Uncertain significance
ndh	2102368	c.675C>T	synonymous_variant	0.23	ethionamide	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
ndh	2102373	p.Met224Leu	missense_variant	0.24	ethionamide
					delamanid
					isoniazid
ndh	2102407	c.636T>C	synonymous_variant	0.25	ethionamide
					delamanid
					isoniazid
ndh	2102413	c.630G>C	synonymous_variant	0.27	ethionamide
					delamanid
					isoniazid
katG	2155632	c.480A>C	synonymous_variant	0.29	isoniazid
katG	2155637	p.Leu159Ile	missense_variant	0.32	isoniazid
katG	2155641	p.Lys157Asn	missense_variant	0.43	isoniazid	Uncertain significance
katG	2155661	p.Val151Ile	missense_variant	0.54	isoniazid
katG	2155680	c.432G>C	synonymous_variant	0.53	isoniazid
katG	2155691	c.421T>C	synonymous_variant	0.56	isoniazid
katG	2155695	c.417C>G	synonymous_variant	0.57	isoniazid
katG	2155704	c.408C>G	synonymous_variant	0.6	isoniazid
katG	2155716	c.396T>G	synonymous_variant	0.6	isoniazid
katG	2155722	c.390G>C	synonymous_variant	0.62	isoniazid
katG	2155728	c.384G>C	synonymous_variant	0.6	isoniazid
katG	2155740	p.Gly124Gln	missense_variant	0.6	isoniazid
katG	2155743	c.369G>C	synonymous_variant	0.6	isoniazid
katG	2155782	c.330C>G	synonymous_variant	0.42	isoniazid
katG	2155785	c.327T>C	synonymous_variant	0.43	isoniazid
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2223491	c.-327C>A	upstream_gene_variant	0.98	clofazimine	Not assoc w R
Rv1979c	2223491	c.-327C>A	upstream_gene_variant	0.98	bedaquiline	Uncertain significance
pncA	2289045	p.Ser66Leu	missense_variant	1.0	pyrazinamide	Not assoc w R - Interim
kasA	2517950	c.-165C>G	upstream_gene_variant	0.75	isoniazid
kasA	2517989	c.-126T>C	upstream_gene_variant	0.61	isoniazid
kasA	2517993	c.-122G>T	upstream_gene_variant	0.6	isoniazid
kasA	2518019	c.-96A>G	upstream_gene_variant	0.47	isoniazid
kasA	2518025	c.-90G>C	upstream_gene_variant	0.42	isoniazid
kasA	2518121	p.Gln3Lys	missense_variant	0.25	isoniazid
kasA	2518132	c.18C>T	synonymous_variant	0.33	isoniazid
kasA	2518138	c.24T>C	synonymous_variant	0.31	isoniazid
kasA	2518146	p.Phe11Tyr	missense_variant	0.28	isoniazid
kasA	2518190	p.Ser26Ala	missense_variant	0.25	isoniazid
kasA	2518248	p.Ala45Val	missense_variant	0.22	isoniazid
kasA	2518421	p.Val103Leu	missense_variant	0.23	isoniazid
kasA	2518439	p.Ala109Ser	missense_variant	0.24	isoniazid
kasA	2518459	c.345T>C	synonymous_variant	0.25	isoniazid
kasA	2518468	c.354A>C	synonymous_variant	0.26	isoniazid
kasA	2518474	c.360G>A	synonymous_variant	0.29	isoniazid
kasA	2518480	c.366T>C	synonymous_variant	0.28	isoniazid
kasA	2518483	c.369C>G	synonymous_variant	0.28	isoniazid
kasA	2518504	c.390T>C	synonymous_variant	0.3	isoniazid
kasA	2518506	p.Ala131Glu	missense_variant	0.29	isoniazid
kasA	2518519	c.405G>C	synonymous_variant	0.32	isoniazid
kasA	2518528	c.414C>G	synonymous_variant	0.31	isoniazid
kasA	2518540	c.426T>C	synonymous_variant	0.32	isoniazid
kasA	2518624	c.510C>G	synonymous_variant	0.26	isoniazid
kasA	2518639	c.525G>C	synonymous_variant	0.36	isoniazid
kasA	2518657	c.543G>C	synonymous_variant	0.47	isoniazid
kasA	2518672	c.558G>C	synonymous_variant	0.53	isoniazid
kasA	2518678	c.564C>T	synonymous_variant	0.57	isoniazid
kasA	2518684	c.570C>G	synonymous_variant	0.61	isoniazid
kasA	2518693	c.579C>G	synonymous_variant	0.58	isoniazid
kasA	2518696	c.582C>G	synonymous_variant	0.58	isoniazid
kasA	2518702	c.588C>T	synonymous_variant	0.57	isoniazid
kasA	2518705	c.591T>C	synonymous_variant	0.6	isoniazid
kasA	2518711	c.597A>G	synonymous_variant	0.61	isoniazid
kasA	2518714	c.600A>C	synonymous_variant	0.61	isoniazid
kasA	2518732	c.618C>G	synonymous_variant	0.66	isoniazid
kasA	2518744	c.630C>T	synonymous_variant	0.72	isoniazid
kasA	2518747	c.633C>G	synonymous_variant	0.71	isoniazid
kasA	2518768	c.654C>T	synonymous_variant	0.71	isoniazid
kasA	2518777	c.663C>T	synonymous_variant	0.7	isoniazid
kasA	2518783	c.669T>C	synonymous_variant	0.7	isoniazid
kasA	2518789	c.675G>C	synonymous_variant	0.69	isoniazid
kasA	2518792	c.678C>A	synonymous_variant	0.67	isoniazid
kasA	2518795	c.681C>G	synonymous_variant	0.67	isoniazid
kasA	2518825	c.711T>C	synonymous_variant	0.6	isoniazid
kasA	2518864	c.750G>C	synonymous_variant	0.5	isoniazid
kasA	2518879	c.765A>G	synonymous_variant	0.38	isoniazid
kasA	2518885	c.771T>C	synonymous_variant	0.33	isoniazid
kasA	2519158	c.1044C>T	synonymous_variant	0.24	isoniazid
kasA	2519167	c.1053T>G	synonymous_variant	0.24	isoniazid
kasA	2519173	c.1059C>G	synonymous_variant	0.27	isoniazid
kasA	2519196	p.Thr361Ser	missense_variant	0.29	isoniazid
kasA	2519215	c.1101C>T	synonymous_variant	0.28	isoniazid
kasA	2519218	c.1104G>A	synonymous_variant	0.28	isoniazid
kasA	2519221	c.1107G>C	synonymous_variant	0.29	isoniazid
kasA	2519227	c.1113G>C	synonymous_variant	0.27	isoniazid
kasA	2519230	c.1116C>T	synonymous_variant	0.26	isoniazid
kasA	2519236	c.1122G>A	synonymous_variant	0.25	isoniazid
kasA	2519239	c.1125A>C	synonymous_variant	0.25	isoniazid
kasA	2519245	c.1131T>C	synonymous_variant	0.26	isoniazid
kasA	2519260	c.1146T>G	synonymous_variant	0.26	isoniazid
kasA	2519263	c.1149C>T	synonymous_variant	0.25	isoniazid
kasA	2519266	c.1152C>T	synonymous_variant	0.25	isoniazid
kasA	2519269	c.1155C>T	synonymous_variant	0.25	isoniazid
kasA	2519281	c.1167G>T	synonymous_variant	0.24	isoniazid
folC	2746308	p.Arg431Ser	missense_variant	0.33	para-aminosalicylic_acid
folC	2746321	c.1278A>G	synonymous_variant	0.31	para-aminosalicylic_acid
folC	2746328	p.Arg424Thr	missense_variant	0.32	para-aminosalicylic_acid
folC	2746335	p.Gly422Arg	missense_variant	0.3	para-aminosalicylic_acid
folC	2746336	c.1263C>G	synonymous_variant	0.3	para-aminosalicylic_acid
folC	2746345	c.1254G>C	synonymous_variant	0.33	para-aminosalicylic_acid
folC	2746351	c.1246_1248delGCCinsTG	frameshift_variant&missense_variant	0.33	para-aminosalicylic_acid
folC	2746354	c.1245G>A	synonymous_variant	0.33	para-aminosalicylic_acid
folC	2746360	c.1239T>C	synonymous_variant	0.33	para-aminosalicylic_acid
folC	2746363	c.1234_1236delCTGinsGC	frameshift_variant&missense_variant	0.34	para-aminosalicylic_acid
folC	2746375	c.1224G>C	synonymous_variant	0.33	para-aminosalicylic_acid
folC	2746390	c.1207_1209delGTGinsAC	frameshift_variant&missense_variant	0.35	para-aminosalicylic_acid
folC	2746393	c.1206C>G	synonymous_variant	0.36	para-aminosalicylic_acid
folC	2746401	p.Ser400Ala	missense_variant	0.33	para-aminosalicylic_acid
folC	2746402	c.1197T>C	synonymous_variant	0.33	para-aminosalicylic_acid
folC	2746414	c.1183_1185delGAGinsCA	frameshift_variant&missense_variant	0.33	para-aminosalicylic_acid
folC	2746420	c.1179A>C	synonymous_variant	0.34	para-aminosalicylic_acid
folC	2746426	c.1173G>C	synonymous_variant	0.31	para-aminosalicylic_acid
folC	2746438	c.1161G>C	synonymous_variant	0.38	para-aminosalicylic_acid
folC	2746451	p.Gly383Ala	missense_variant	0.38	para-aminosalicylic_acid
folC	2746471	c.1128C>A	synonymous_variant	0.4	para-aminosalicylic_acid
folC	2746478	p.Phe374Tyr	missense_variant	0.4	para-aminosalicylic_acid
folC	2746480	c.1119A>C	synonymous_variant	0.4	para-aminosalicylic_acid
folC	2746492	c.1107G>A	synonymous_variant	0.4	para-aminosalicylic_acid
folC	2746495	p.His368Gly	missense_variant	0.41	para-aminosalicylic_acid
folC	2746507	c.1092A>G	synonymous_variant	0.37	para-aminosalicylic_acid
folC	2746510	c.1089A>G	synonymous_variant	0.38	para-aminosalicylic_acid
folC	2746516	c.1083T>G	synonymous_variant	0.38	para-aminosalicylic_acid
folC	2746519	p.Ser360Ala	missense_variant	0.39	para-aminosalicylic_acid
folC	2746522	c.1077G>C	synonymous_variant	0.38	para-aminosalicylic_acid
folC	2746525	c.1074G>T	synonymous_variant	0.4	para-aminosalicylic_acid
folC	2746531	c.1068G>C	synonymous_variant	0.39	para-aminosalicylic_acid
folC	2746534	c.1065T>C	synonymous_variant	0.44	para-aminosalicylic_acid
folC	2746558	c.1041G>T	synonymous_variant	0.42	para-aminosalicylic_acid
folC	2746564	c.1035A>G	synonymous_variant	0.42	para-aminosalicylic_acid
folC	2746576	c.1023C>G	synonymous_variant	0.36	para-aminosalicylic_acid
folC	2746584	c.1015T>C	synonymous_variant	0.33	para-aminosalicylic_acid
folC	2747021	p.Val193Ala	missense_variant	0.29	para-aminosalicylic_acid
folC	2747023	c.576C>G	synonymous_variant	0.27	para-aminosalicylic_acid
folC	2747026	c.573C>G	synonymous_variant	0.27	para-aminosalicylic_acid
folC	2747062	c.537A>G	synonymous_variant	0.25	para-aminosalicylic_acid
folC	2747065	c.534C>T	synonymous_variant	0.23	para-aminosalicylic_acid
folC	2747317	c.282C>G	synonymous_variant	0.23	para-aminosalicylic_acid
folC	2747343	p.Val86Ile	missense_variant	0.31	para-aminosalicylic_acid
folC	2747355	p.Val82Ile	missense_variant	0.33	para-aminosalicylic_acid
folC	2747394	p.Ile69Val	missense_variant	0.32	para-aminosalicylic_acid
folC	2747395	c.204T>C	synonymous_variant	0.33	para-aminosalicylic_acid
folC	2747407	c.192T>C	synonymous_variant	0.31	para-aminosalicylic_acid
folC	2747410	c.187_188delAG	frameshift_variant	0.3	para-aminosalicylic_acid
folC	2747415	c.184delCinsTTG	frameshift_variant&missense_variant	0.31	para-aminosalicylic_acid
folC	2747419	c.180C>G	synonymous_variant	0.31	para-aminosalicylic_acid
folC	2747422	c.177G>A	synonymous_variant	0.32	para-aminosalicylic_acid
folC	2747425	c.174C>T	synonymous_variant	0.32	para-aminosalicylic_acid
folC	2747442	c.157T>C	synonymous_variant	0.33	para-aminosalicylic_acid
Rv2477c	2783140	c.903C>G	synonymous_variant	0.53	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783149	c.894G>C	synonymous_variant	0.54	ethambutol
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783158	c.885A>C	synonymous_variant	0.57	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783182	c.861C>G	synonymous_variant	0.6	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783185	c.858G>A	synonymous_variant	0.59	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783194	c.849A>G	synonymous_variant	0.64	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783221	c.822G>C	synonymous_variant	0.67	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783224	c.819C>G	synonymous_variant	0.66	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783230	c.813T>G	synonymous_variant	0.65	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2783235	c.808T>C	synonymous_variant	0.66	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783254	c.789A>G	synonymous_variant	0.66	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783263	c.780G>C	synonymous_variant	0.65	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783275	c.768C>G	synonymous_variant	0.63	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783278	c.765A>G	synonymous_variant	0.63	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783293	c.750G>A	synonymous_variant	0.57	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783299	c.744A>G	synonymous_variant	0.59	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783302	c.741A>G	synonymous_variant	0.57	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783311	c.732T>C	synonymous_variant	0.57	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783314	c.729C>G	synonymous_variant	0.55	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					levofloxacin
					kanamycin
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2783317	c.726G>C	synonymous_variant	0.59	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783332	c.711T>C	synonymous_variant	0.49	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783335	c.708C>G	synonymous_variant	0.49	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783350	c.693T>C	synonymous_variant	0.4	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783353	c.690T>C	synonymous_variant	0.39	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783359	c.684G>A	synonymous_variant	0.38	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783374	c.669G>C	synonymous_variant	0.4	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783395	c.648T>G	synonymous_variant	0.37	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783473	c.570A>C	synonymous_variant	0.25	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783485	c.558G>C	synonymous_variant	0.29	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783497	c.544_546delTTGinsCC	frameshift_variant&missense_variant	0.32	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					kanamycin	Uncertain significance
					rifampicin	Uncertain significance
					amikacin	Uncertain significance
Rv2477c	2783502	c.541T>C	synonymous_variant	0.34	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783512	c.531A>G	synonymous_variant	0.34	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783520	c.523T>C	synonymous_variant	0.32	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2783527	c.516A>G	synonymous_variant	0.31	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783539	c.504G>C	synonymous_variant	0.3	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783542	c.501G>C	synonymous_variant	0.29	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783548	c.495T>C	synonymous_variant	0.3	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783554	c.489C>T	synonymous_variant	0.3	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783563	c.480A>G	synonymous_variant	0.31	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783572	c.471A>G	synonymous_variant	0.32	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783586	p.Ala153Pro	missense_variant	0.32	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783674	c.369T>A	synonymous_variant	0.31	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783683	c.360A>G	synonymous_variant	0.36	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783700	p.Thr115Ser	missense_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783718	c.325T>C	synonymous_variant	0.52	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783719	c.324A>G	synonymous_variant	0.53	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783751	p.Ile98Val	missense_variant	0.64	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783758	p.Asp95Glu	missense_variant	0.66	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783761	c.282G>C	synonymous_variant	0.67	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783766	p.Met93Leu	missense_variant	0.66	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783776	c.267G>C	synonymous_variant	0.7	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783779	c.264T>C	synonymous_variant	0.7	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783797	p.Asp82Glu	missense_variant	0.74	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783815	c.228A>G	synonymous_variant	0.74	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783821	p.Gln74Leu	missense_variant	0.73	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783833	c.210G>C	synonymous_variant	0.74	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783839	c.204C>G	synonymous_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783843	p.Gly67Asp	missense_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783846	p.Thr66Asn	missense_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783860	c.183T>C	synonymous_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783863	c.180C>T	synonymous_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783883	c.160T>C	synonymous_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783884	c.159T>C	synonymous_variant	0.73	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783887	c.156C>G	synonymous_variant	0.73	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783914	c.129T>C	synonymous_variant	0.76	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783920	c.123G>C	synonymous_variant	0.77	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783929	c.114C>G	synonymous_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783932	c.111C>T	synonymous_variant	0.78	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783938	c.105T>C	synonymous_variant	0.79	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783953	c.90G>A	synonymous_variant	0.69	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783962	c.81T>C	synonymous_variant	0.68	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783971	c.72G>C	synonymous_variant	0.68	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783980	c.63C>G	synonymous_variant	0.62	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783992	c.51T>C	synonymous_variant	0.59	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2784589	c.-547A>C	upstream_gene_variant	1.0	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
pepQ	2859765	c.654G>C	synonymous_variant	0.3	clofazimine
pepQ	2859765	c.654G>C	synonymous_variant	0.3	bedaquiline
pepQ