TB-Profiler result

Run: ERR9786525
Summary

Run ID: ERR9786525

Sample name:

Date: 2024-10-04T22:02:56.827532

Number of reads: 1975812

Percentage reads mapped: 71.51

Median coverage: 86.0

Strain: lineage4.1;lineage4.8

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.67
lineage4 Euro-American None 0.93
lineage4.8 Euro-American (mainly T) RD219 0.22
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Leu359Ile Uncertain significance Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance Mutation from literature
embB 4247588 p.Leu359Ile missense_variant 0.22 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 371 p.Pro124Leu missense_variant 0.4 isoniazid Not assoc w R
dnaA 741 c.741T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 753 c.753C>A synonymous_variant 0.19 isoniazid
dnaA 798 c.798C>T synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 813 c.813C>T synonymous_variant 0.19 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.19 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.21 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.2 isoniazid
dnaA 909 c.909A>G synonymous_variant 0.2 isoniazid
dnaA 912 c.912T>G synonymous_variant 0.2 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.2 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.22 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.19 isoniazid
dnaA 963 c.963C>A synonymous_variant 0.17 isoniazid
dnaA 1029 c.1029C>T synonymous_variant 0.19 isoniazid
gyrB 6215 p.Ser326Thr missense_variant 0.22 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6238 c.999G>A synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.23 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6256 c.1017G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6301 c.1062G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6367 c.-935C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6457 c.-845T>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6507 p.Ala423Val missense_variant 0.5 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6610 c.-692C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6784 c.-518C>T upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.33 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6838 c.-464C>T upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6853 c.-449A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6865 c.-437G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6866 c.-436C>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6889 c.-413G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.3 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6931 c.1692A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6970 c.-332C>T upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7021 c.-281G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7030 c.-272C>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 7057 c.-245C>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7099 c.-203G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7124 p.Ser629Thr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7502 c.201C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7526 c.225G>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7538 c.237G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.74 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7655 c.354G>A synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCTC synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7727 c.426G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7769 c.468C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7778 c.477G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8228 c.927G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCTG synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8246 c.945C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8247 p.Ile316Val missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8267 c.966G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.3 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8546 p.Asp415Glu missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 8552 c.1251C>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8576 c.1275C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8690 c.1389C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8705 c.1404C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8708 c.1407G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8783 c.1482G>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8817 p.Ser506Ala missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8822 c.1521C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8843 c.1542G>A synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8849 c.1548C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8885 c.1584C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8990 c.1689C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9002 c.1701C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9204 p.Ser635Thr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9212 c.1911G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9260 c.1959G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 0.77 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9362 c.2061C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9365 c.2064G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9656 c.2355C>G synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 490902 c.120T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490905 c.123T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490911 c.129T>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490917 c.135C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 490932 c.150T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 490948 p.Ser56Ala missense_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 490962 c.180T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 490974 c.192T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 490980 p.Asn66Lys missense_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 490987 p.Leu69Val missense_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 490998 c.216T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491007 c.225G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491013 c.231C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491064 c.282A>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491082 c.300T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491083 p.Val101Ile missense_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491091 c.309T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491097 c.315G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491106 c.324T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491115 c.333G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491121 c.339A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 491144 p.Ala121Glu missense_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491166 c.384G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491168 p.Phe129Tyr missense_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491181 c.399T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491191 p.Gly137Arg missense_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491196 c.414A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491203 p.Gln141Glu missense_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Leu missense_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
mshA 575587 c.240C>G synonymous_variant 0.21 isoniazid
ethionamide
mshA 575590 c.243T>G synonymous_variant 0.21 isoniazid
ethionamide
mshA 575593 c.246G>C synonymous_variant 0.21 isoniazid
ethionamide
mshA 575617 c.270C>G synonymous_variant 0.23 isoniazid
ethionamide
mshA 575623 c.276C>G synonymous_variant 0.24 isoniazid
ethionamide
mshA 575629 c.282A>C synonymous_variant 0.23 isoniazid
ethionamide
mshA 575635 c.288A>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
ethionamide
mshA 575638 c.291T>C synonymous_variant 0.24 isoniazid
ethionamide
mshA 575641 c.294A>G synonymous_variant 0.23 isoniazid
ethionamide
mshA 575647 c.300G>C synonymous_variant 0.24 isoniazid
ethionamide
mshA 575649 p.Val101Ala missense_variant 0.25 isoniazid
ethionamide
mshA 575659 c.312A>G synonymous_variant 0.27 isoniazid
ethionamide
mshA 575674 c.327G>C synonymous_variant 0.26 isoniazid
ethionamide
mshA 575692 c.345G>C synonymous_variant 0.24 isoniazid
ethionamide
mshA 575695 c.348C>G synonymous_variant 0.22 isoniazid Not assoc w R - Interim
ethionamide
mshA 575704 c.357T>C synonymous_variant 0.23 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.23 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.22 isoniazid
ethionamide
mshA 575722 c.375G>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.24 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575746 c.399C>T synonymous_variant 0.22 isoniazid
ethionamide
mshA 575770 c.423G>T synonymous_variant 0.22 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.22 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.21 isoniazid
ethionamide
mshA 575782 c.435G>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.24 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.21 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.21 isoniazid
ethionamide
mshA 575833 c.486C>T synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
ccsA 619535 c.-356C>T upstream_gene_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 619555 c.-336C>G upstream_gene_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 619574 c.-317G>A upstream_gene_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 619579 c.-312G>C upstream_gene_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 619591 c.-300G>C upstream_gene_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 619594 c.-297G>C upstream_gene_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 619618 c.-273C>G upstream_gene_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 619627 c.-264C>G upstream_gene_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 619634 c.-257T>A upstream_gene_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620198 p.Gln103Leu missense_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620226 c.336G>A synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620245 c.355T>C synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620249 p.Ser120Cys missense_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620254 c.364_366delCTCinsTTG synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620265 c.375C>G synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620283 c.393T>C synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620284 p.Ala132Pro missense_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620288 p.Arg133Gln missense_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>C synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620307 c.417C>G synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620349 c.459A>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.2 kanamycin
capreomycin
amikacin
Rv0565c 657269 p.Ser68Pro missense_variant 0.59 ethionamide Uncertain significance
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.23 ethionamide
hadA 732295 c.366G>C synonymous_variant 0.2 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.2 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.2 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.2 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.25 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.26 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.29 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.29 isoniazid
hadA 732355 c.426G>C synonymous_variant 0.31 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.34 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.33 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.35 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.34 isoniazid
nusG 734481 c.228C>T synonymous_variant 0.18 rifampicin
nusG 734538 c.285C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.2 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.19 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.27 rifampicin
nusG 734596 c.343_345delTTGinsCTC synonymous_variant 0.29 rifampicin
nusG 734604 c.351C>T synonymous_variant 0.32 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.31 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.27 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.29 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.27 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.27 rifampicin
nusG 734646 c.393G>C synonymous_variant 0.27 rifampicin
nusG 734658 c.405A>G synonymous_variant 0.27 rifampicin Not assoc w R
nusG 734661 c.408A>C synonymous_variant 0.28 rifampicin
nusG 734664 c.411T>G synonymous_variant 0.29 rifampicin
nusG 734667 c.414C>T synonymous_variant 0.29 rifampicin
nusG 734673 c.420A>G synonymous_variant 0.29 rifampicin
nusG 734679 c.426C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734680 p.Ala143Thr missense_variant 0.29 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.3 rifampicin
nusG 734709 c.456T>G synonymous_variant 0.31 rifampicin
nusG 734715 c.462G>C synonymous_variant 0.3 rifampicin
nusG 734718 c.465G>C synonymous_variant 0.29 rifampicin
nusG 734719 p.Ser156Ala missense_variant 0.29 rifampicin
nusG 734726 p.Arg158Lys missense_variant 0.27 rifampicin
nusG 734733 c.480T>C synonymous_variant 0.27 rifampicin
nusG 734742 c.489T>C synonymous_variant 0.19 rifampicin
nusG 734750 p.Ser166Thr missense_variant 0.27 rifampicin
nusG 734757 c.504T>C synonymous_variant 0.25 rifampicin
nusG 734771 p.Ala173Val missense_variant 0.23 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.21 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.21 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.2 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.2 rifampicin Uncertain significance
rpoB 760181 c.375T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.32 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.43 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.34 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.34 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.33 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.34 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.33 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.31 rifampicin
rpoB 760412 c.606C>T synonymous_variant 0.21 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760520 c.714C>G synonymous_variant 0.35 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.36 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.32 rifampicin
rpoB 760547 c.741G>T synonymous_variant 0.2 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.34 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.35 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.3 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.27 rifampicin
rpoB 760755 p.His317Asn missense_variant 0.27 rifampicin
rpoB 760765 p.Glu320Ala missense_variant 0.27 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.26 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.28 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.3 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.3 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.3 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.34 rifampicin
rpoB 760856 c.1050C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760859 c.1053T>C synonymous_variant 0.35 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.33 rifampicin
rpoB 760883 c.1077G>C synonymous_variant 0.35 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.36 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.36 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.37 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.32 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.32 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.31 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.34 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>G synonymous_variant 0.38 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.38 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.38 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.4 rifampicin
rpoB 761138 c.1332C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.47 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.31 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.31 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761361 c.1555_1556delAGinsTC synonymous_variant 0.28 rifampicin
rpoB 761373 p.Val523His missense_variant 0.27 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.26 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.25 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.26 rifampicin
rpoB 761437 p.Ala544Asp missense_variant 0.26 rifampicin
rpoB 761439 p.Asp545Lys missense_variant 0.27 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.27 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.28 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.28 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.3 rifampicin
rpoB 761465 c.1659G>C synonymous_variant 0.34 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.32 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.34 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.36 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.38 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.39 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.38 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.37 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.34 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.31 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.3 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.3 rifampicin
rpoB 761699 c.1893C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761711 c.1905C>G synonymous_variant 0.28 rifampicin
rpoB 761714 c.1908C>G synonymous_variant 0.28 rifampicin
rpoB 761717 c.1911C>G synonymous_variant 0.27 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.28 rifampicin
rpoB 761735 c.1929C>G synonymous_variant 0.3 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.31 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.31 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.34 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.3 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.31 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.34 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.31 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.31 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.32 rifampicin
rpoB 761846 c.2040G>A synonymous_variant 0.27 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.27 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.28 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.29 rifampicin
rpoB 761867 c.2061C>G synonymous_variant 0.3 rifampicin
rpoB 761870 p.Asp688Glu missense_variant 0.31 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.31 rifampicin
rpoB 761876 c.2070C>G synonymous_variant 0.31 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.31 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.32 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.32 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.34 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.34 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.34 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.37 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.47 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.45 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.43 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762074 c.2268C>G synonymous_variant 0.45 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.46 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.45 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.43 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.39 rifampicin
rpoB 762284 c.2478G>T synonymous_variant 0.35 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.35 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.34 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.33 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.34 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.31 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.3 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.33 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.3 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.18 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.2 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.17 rifampicin
rpoB 762750 p.Leu982Met missense_variant 0.18 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.38 rifampicin Uncertain significance
rpoB 762789 p.Leu995Met missense_variant 0.38 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.4 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.4 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.41 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 762821 c.-549C>T upstream_gene_variant 0.25 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762833 c.3027C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 762863 c.-507T>G upstream_gene_variant 0.46 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.51 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.5 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.5 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 762998 c.-372G>A upstream_gene_variant 0.31 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.34 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.3 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.38 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.2 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.26 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.39 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763561 c.192G>A synonymous_variant 0.29 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.41 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.45 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.44 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.44 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.44 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.44 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.43 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.44 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.37 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.31 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.28 rifampicin
rpoC 763852 c.483C>G synonymous_variant 0.23 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.22 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.22 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.23 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.23 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.24 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.25 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.26 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763933 c.564C>G synonymous_variant 0.31 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.3 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.32 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.3 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.32 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.33 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.34 rifampicin
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.33 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.33 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.32 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.32 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.35 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.37 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.37 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.39 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.45 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764198 c.829C>T synonymous_variant 0.41 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.4 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764213 p.Arg282Lys missense_variant 0.38 rifampicin Uncertain significance
rpoC 764257 c.888G>C synonymous_variant 0.42 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.4 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.4 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.39 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>A synonymous_variant 0.39 rifampicin
rpoC 764383 c.1014C>G synonymous_variant 0.38 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.34 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.34 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.34 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.33 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.34 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.35 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.35 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>C synonymous_variant 0.33 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.33 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.31 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.3 rifampicin
rpoC 764647 c.1278C>T synonymous_variant 0.33 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764720 c.1351C>T synonymous_variant 0.27 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.45 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.34 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.32 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.68 rifampicin Not assoc w R
rpoC 765187 c.1818C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 765319 c.1950A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.24 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.24 rifampicin Uncertain significance
rpoC 765361 c.1992C>A synonymous_variant 0.25 rifampicin
rpoC 765370 c.2001G>T synonymous_variant 0.25 rifampicin
rpoC 765371 c.2002C>T synonymous_variant 0.25 rifampicin
rpoC 765379 c.2010G>T synonymous_variant 0.28 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.28 rifampicin Uncertain significance
rpoC 765394 c.2025G>A synonymous_variant 0.28 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.29 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.27 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.28 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.27 rifampicin
rpoC 765452 p.Ala695Ser missense_variant 0.26 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.32 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.31 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.33 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.35 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.35 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.35 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.36 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.24 rifampicin
rpoC 765637 c.2268C>T synonymous_variant 0.2 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.38 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.39 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.39 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.39 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.39 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.38 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.39 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.39 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.36 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.34 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>G synonymous_variant 0.41 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766010 p.Ser881Arg missense_variant 0.29 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.33 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.33 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.29 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.22 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.23 rifampicin
rpoC 766097 p.Leu910Val missense_variant 0.18 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.2 rifampicin
rpoC 766327 c.2958C>G synonymous_variant 0.2 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.21 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.21 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.22 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.23 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.25 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.25 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.26 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766411 c.3042C>G synonymous_variant 0.27 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.26 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.33 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.38 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.38 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.38 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.42 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.47 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.46 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.47 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.41 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.42 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.42 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.43 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.4 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.42 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.43 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.44 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.44 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.45 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.38 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.38 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.38 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.36 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.39 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.43 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.43 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.43 rifampicin
rpoC 766918 c.3549C>G synonymous_variant 0.43 rifampicin
rpoC 766921 c.3552G>C synonymous_variant 0.42 rifampicin
rpoC 766924 p.Glu1185Asp missense_variant 0.41 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.43 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.46 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.45 rifampicin
rpoC 766987 c.3618G>C synonymous_variant 0.45 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767032 c.3663G>A synonymous_variant 0.44 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.4 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767105 p.Asn1246Gln missense_variant 0.3 rifampicin Uncertain significance
rpoC 767119 c.3750A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.25 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.22 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776656 p.Gly609Arg missense_variant 0.3 bedaquiline Uncertain significance
clofazimine Uncertain significance
rpsL 781138 c.-422C>G upstream_gene_variant 0.18 streptomycin
rpsL 781153 c.-407G>T upstream_gene_variant 0.19 streptomycin
rpsL 781170 c.-390G>C upstream_gene_variant 0.18 streptomycin
rpsL 781188 c.-372G>T upstream_gene_variant 0.18 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781421 c.-139C>A upstream_gene_variant 0.66 streptomycin Uncertain significance
rpsL 781571 c.12C>T synonymous_variant 0.17 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.23 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.23 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.22 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.22 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.34 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.34 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.36 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.39 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.39 streptomycin
rpsL 781718 c.159C>T synonymous_variant 0.38 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.39 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.39 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.41 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.4 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.41 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.39 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.39 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.37 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.4 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.4 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.38 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.36 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.37 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.36 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.37 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.36 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.36 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.36 streptomycin Uncertain significance
rplC 800537 c.-272C>T upstream_gene_variant 0.16 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.19 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.23 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.29 linezolid
rplC 800703 c.-106_-104delTTGinsCTC upstream_gene_variant 0.29 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.28 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.27 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.29 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.28 linezolid
rplC 800744 c.-65G>C upstream_gene_variant 0.29 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.29 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.27 linezolid
rplC 800798 c.-11T>C upstream_gene_variant 0.21 linezolid
rplC 800801 c.-8_-6delACAinsC upstream_gene_variant 0.23 linezolid
rplC 800806 c.-3G>C upstream_gene_variant 0.21 linezolid
rplC 800807 c.-2C>T upstream_gene_variant 0.21 linezolid
rplC 800808 c.-1A>C upstream_gene_variant 0.21 linezolid Uncertain significance
rplC 800815 c.7C>A synonymous_variant 0.2 linezolid
rplC 800820 c.12G>A synonymous_variant 0.21 linezolid
rplC 800829 c.21C>G synonymous_variant 0.22 linezolid
rplC 800844 c.36T>C synonymous_variant 0.2 linezolid
rplC 801207 c.399C>T synonymous_variant 0.16 linezolid
rplC 801210 c.402T>C synonymous_variant 0.18 linezolid
rplC 801307 p.Ala167Ser missense_variant 0.19 linezolid
rplC 801321 c.513C>T synonymous_variant 0.18 linezolid Not assoc w R - Interim
rplC 801348 c.540T>G synonymous_variant 0.18 linezolid
rplC 801357 c.549T>C synonymous_variant 0.21 linezolid
rplC 801396 c.588T>C synonymous_variant 0.24 linezolid
rplC 801402 c.594T>C synonymous_variant 0.25 linezolid
rplC 801405 c.597T>C synonymous_variant 0.23 linezolid
rplC 801423 c.615G>C synonymous_variant 0.23 linezolid
rplC 801427 p.Met207Val missense_variant 0.22 linezolid
rplC 801438 c.630T>C synonymous_variant 0.22 linezolid
rplC 801442 p.Ile212Val missense_variant 0.24 linezolid
fbiC 1303590 c.660A>T synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303608 c.678G>A synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>T synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303647 c.717G>T synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303661 p.Val244Ala missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303674 c.744C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303677 c.747C>A synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303686 c.756C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303727 p.Thr266Asn missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Thr missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.3 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>T synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303788 c.858T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303794 c.864A>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1303890 c.960G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303897 c.967C>T synonymous_variant 0.33 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303908 c.978C>A synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303911 c.981G>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303923 c.993C>T synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303932 c.1002G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303935 c.1005G>T synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303956 c.1026A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303961 p.Arg344Leu missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303969 p.Val347Ile missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303980 c.1050G>A synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303986 c.1056C>T synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304001 c.1071C>T synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304008 c.1078T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304022 c.1092T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304058 p.Glu376Asp missense_variant 0.17 pretomanid
delamanid Uncertain significance
clofazimine
fbiC 1304610 c.1680C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304625 c.1695C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304671 p.Val581Thr missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Glu missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>A synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>T synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Glu missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.3 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1304790 c.1860C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304796 c.1866G>A synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304853 c.1923C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304880 c.1950C>T synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304925 c.1995G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304940 c.2010A>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304955 c.2025G>A synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304970 c.2040G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304995 c.2065T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305012 c.2082G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305014 p.Thr695Ser missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>A synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1305033 c.2103T>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1305039 c.2109G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1305042 c.2112A>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1305045 c.2115A>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1305066 c.2136T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1305069 c.2139G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1305075 c.2145T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305078 c.2148A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305092 p.Ala721Gly missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305096 c.2166T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305099 c.2169T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305114 c.2184T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305117 c.2187T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305135 c.2205C>T synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305144 c.2214G>A synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305150 c.2220C>A synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305174 c.2244T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305181 c.2251T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305186 c.2256C>T synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305195 c.2265T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305199 p.Ala757Ser missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305215 p.Ser762Thr missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1305231 c.2301C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1305237 c.2307A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305244 c.2314T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305249 c.2319G>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
sigE 1364835 c.423C>G synonymous_variant 0.19 pyrazinamide
sigE 1364889 c.477A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
sigE 1364898 c.486C>T synonymous_variant 0.18 pyrazinamide
sigE 1364910 c.498G>T synonymous_variant 0.17 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473752 n.95G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473936 n.279A>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.76 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475758 n.2104delC non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.31 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476030 n.2373_2377delACCTCinsGTACA non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
inhA 1673601 c.-601G>A upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673610 c.-592C>T upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673625 c.-577C>G upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673633 c.-569G>A upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673657 c.-545C>A upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673660 c.-542C>A upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673710 c.-492C>A upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673716 c.-486G>A upstream_gene_variant 0.18 isoniazid Uncertain significance
ethionamide
inhA 1674060 c.-142A>G upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1674079 c.-123C>G upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1674084 c.-118C>G upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1674114 c.-88T>G upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1674123 c.-79T>C upstream_gene_variant 0.25 isoniazid
ethionamide
inhA 1674129 c.-73C>T upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1674132 c.-70T>C upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1674136 c.-66T>G upstream_gene_variant 0.22 isoniazid
ethionamide
inhA 1674324 c.123C>T synonymous_variant 0.25 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674331 c.130C>T synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674336 c.135G>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674352 p.Thr51Ala missense_variant 0.24 isoniazid
ethionamide Uncertain significance
inhA 1674368 p.Ala56Glu missense_variant 0.22 isoniazid
ethionamide
inhA 1674375 c.174C>G synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674382 p.Leu61Ile missense_variant 0.21 isoniazid
ethionamide
inhA 1674399 c.198A>G synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674443 p.Ala81Glu missense_variant 0.23 isoniazid
ethionamide
inhA 1674450 c.249G>C synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674452 p.Ala84Glu missense_variant 0.3 isoniazid
ethionamide
inhA 1674471 c.270G>T synonymous_variant 0.36 isoniazid
ethionamide
inhA 1674480 c.279T>C synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674486 c.285T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674489 c.288G>T synonymous_variant 0.47 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.51 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.49 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.45 isoniazid
ethionamide
inhA 1674550 p.Ser117Ala missense_variant 0.44 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.44 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.45 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.47 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.44 isoniazid
ethionamide
inhA 1674601 p.Leu134Thr missense_variant 0.41 isoniazid
ethionamide
inhA 1674624 c.423A>T synonymous_variant 0.36 isoniazid
ethionamide
inhA 1674627 c.426T>C synonymous_variant 0.49 isoniazid
ethionamide
inhA 1674636 c.435C>G synonymous_variant 0.51 isoniazid
ethionamide
inhA 1674690 c.489C>G synonymous_variant 0.48 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.47 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.46 isoniazid
ethionamide
inhA 1674714 c.513C>G synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674729 c.528G>T synonymous_variant 0.45 isoniazid
ethionamide
inhA 1674738 c.537C>G synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674746 p.Tyr182Phe missense_variant 0.43 isoniazid
ethionamide
inhA 1674750 c.549T>C synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674756 c.555T>A synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674771 c.570C>G synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.45 isoniazid
ethionamide
inhA 1674786 c.585G>A synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674789 c.588G>C synonymous_variant 0.45 isoniazid
ethionamide
inhA 1674795 c.594G>C synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.45 isoniazid
ethionamide
inhA 1674804 c.603G>C synonymous_variant 0.45 isoniazid
ethionamide Not assoc w R - Interim
inhA 1674816 c.615T>G synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674837 c.636C>G synonymous_variant 0.31 isoniazid
ethionamide
inhA 1674840 c.639C>G synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.43 isoniazid
ethionamide
inhA 1674858 c.657G>A synonymous_variant 0.43 isoniazid
ethionamide
inhA 1674870 c.669T>C synonymous_variant 0.45 isoniazid
ethionamide
inhA 1674879 c.678T>C synonymous_variant 0.43 isoniazid
ethionamide
inhA 1674903 c.702T>C synonymous_variant 0.36 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.36 isoniazid
ethionamide
inhA 1674934 c.733C>T synonymous_variant 0.35 isoniazid
ethionamide
inhA 1674939 c.738G>C synonymous_variant 0.34 isoniazid
ethionamide
inhA 1674942 c.741T>G synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674957 c.756G>C synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674960 c.759C>G synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674966 c.765T>G synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674967 p.Asp256Thr missense_variant 0.29 isoniazid
ethionamide
inhA 1674993 c.792G>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674994 p.His265Ser missense_variant 0.28 isoniazid
ethionamide
inhA 1675008 c.807C>G synonymous_variant 0.22 isoniazid
ethionamide
inhA 1675010 c.799delG frameshift_variant 0.21 isoniazid
ethionamide
rpsA 1833251 c.-291A>G upstream_gene_variant 0.19 pyrazinamide
rpsA 1833257 c.-285C>A upstream_gene_variant 0.19 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.24 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.3 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.3 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1833793 c.252C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.32 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.31 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.3 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.36 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.36 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.37 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.43 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.4 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834546 c.1005T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.41 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.36 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834684 c.1143C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.24 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.22 pyrazinamide
rpsA 1834775 p.Ala412Asn missense_variant 0.18 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.18 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.32 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.29 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.29 linezolid
tsnR 1853390 c.-216G>A upstream_gene_variant 0.27 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.26 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.25 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.24 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.24 linezolid
tsnR 1853444 c.-162C>T upstream_gene_variant 0.21 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.2 linezolid
tsnR 1853459 c.-147G>T upstream_gene_variant 0.19 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 0.69 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2155824 c.288C>T synonymous_variant 0.73 isoniazid Not assoc w R - Interim
katG 2156007 c.105C>T synonymous_variant 0.72 isoniazid Not assoc w R - Interim
PPE35 2168448 p.Gln722Arg missense_variant 0.51 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223421 c.-257G>A upstream_gene_variant 0.61 bedaquiline
clofazimine
kasA 2517917 c.-198G>T upstream_gene_variant 0.28 isoniazid
kasA 2517926 c.-189G>A upstream_gene_variant 0.29 isoniazid
kasA 2517950 c.-165C>T upstream_gene_variant 0.32 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.28 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.27 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.28 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.17 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.21 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.22 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.31 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.32 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.3 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.33 isoniazid
kasA 2518591 c.477G>T synonymous_variant 0.34 isoniazid
kasA 2518603 c.489G>C synonymous_variant 0.34 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.35 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.35 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.38 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.41 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.41 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.45 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.45 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.47 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.46 isoniazid
kasA 2518696 c.582C>T synonymous_variant 0.21 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.43 isoniazid
kasA 2518705 c.591T>G synonymous_variant 0.42 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.44 isoniazid
kasA 2518714 c.600A>T synonymous_variant 0.43 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.44 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.36 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.33 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.34 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.31 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.31 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.31 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.27 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.25 isoniazid
kasA 2518843 c.729T>G synonymous_variant 0.24 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.23 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.24 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.26 isoniazid
kasA 2518867 c.753G>A synonymous_variant 0.26 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.21 isoniazid
kasA 2518882 c.768C>T synonymous_variant 0.21 isoniazid
kasA 2518897 c.783G>A synonymous_variant 0.19 isoniazid
folC 2747059 c.540T>C synonymous_variant 0.21 para-aminosalicylic_acid
Rv2477c 2782510 c.1533G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782581 c.1461_1462insAA frameshift_variant 0.24 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2782585 c.1457_1458insC frameshift_variant 0.24 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2782588 c.1452_1454delTCT disruptive_inframe_deletion 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782594 c.1449T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782603 c.1440G>A synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782608 p.Gly479Ser missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782609 c.1434G>C synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782612 c.1431T>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782621 c.1422T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782624 c.1419G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782633 c.1410G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782636 c.1407G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782639 c.1404A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782645 c.1398C>T synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782651 c.1392T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782669 c.1374A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782680 c.1363T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782684 c.1359T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782705 c.1338G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782714 c.1329A>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782720 c.1323T>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782729 c.1314A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782732 c.1311A>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782738 c.1305C>T synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782747 c.1296G>A synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782750 c.1293T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782759 c.1284A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782777 c.1266A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782795 c.1248T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782847 p.Arg399Lys missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782861 c.1182T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.2 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2782873 c.1170C>T synonymous_variant 0.19 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782876 c.1167G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782879 c.1164C>T synonymous_variant 0.2 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782882 c.1161T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782885 c.1158G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782913 p.Ser377Ile missense_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Gln missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.34 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.36 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.44 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>G synonymous_variant 0.46 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.43 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>C synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>T synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.42 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.43 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783193 p.Ser284Gly missense_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783244 p.Thr267Ala missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.25 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.25 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783554 c.489C>T synonymous_variant 0.25 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783680 c.363G>A synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.37 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.25 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783695 c.348C>T synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 c.285C>T synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783770 c.273G>A synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783812 c.231G>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783838 p.Thr69Ser missense_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783853 c.190C>T synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.26 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rif