TB-Profiler result

Run: ERR9119500
Summary

Run ID: ERR9119500

Sample name:

Date: 2024-03-27T01:19:38.129815

Number of reads: 4182358

Percentage reads mapped: 65.12

Median coverage: 129.0

Strain: lineage5.2

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage5.2 West-Africa 1 RD711 0.97
lineage5 West-Africa 1 RD711 0.88
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1294_1296delCAAinsAG Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.His445Asp Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embA c.-29_-28delCT Uncertain significance Mutation from literature
embB p.Met306Ile Assoc w R
p.His312Arg Mutation from literature
pyrazinamide pncA p.Gln10Pro Assoc w R
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.301_303delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.916_918delTTCinsGT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1825_1827delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491083 c.301_303delGTTinsAC frameshift_variant&missense_variant 0.2 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rpoB 761100 c.1294_1296delCAAinsAG frameshift_variant&missense_variant 0.6 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.36 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761139 p.His445Asp missense_variant 0.61 rifampicin Assoc w R
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.41 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303846 c.916_918delTTCinsGT frameshift_variant&missense_variant 0.39 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304755 c.1825_1827delCTAinsTG frameshift_variant&stop_gained 0.35 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.21 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 0.87 isoniazid Assoc w R High-level resistance
pncA 2289213 p.Gln10Pro missense_variant 1.0 pyrazinamide Assoc w R
embA 4243203 c.-29_-28delCT upstream_gene_variant 1.0 ethambutol Uncertain significance Mutation from literature
embB 4247431 p.Met306Ile missense_variant 0.8 ethambutol Assoc w R
embB 4247448 p.His312Arg missense_variant 0.2 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 975 c.975G>T synonymous_variant 0.21 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>G synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 996 c.996A>T synonymous_variant 0.19 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.22 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.24 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.24 isoniazid
dnaA 1050 c.1050G>C synonymous_variant 0.23 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.25 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.24 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.24 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.24 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.23 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.23 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.27 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.28 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.28 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.27 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.28 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.26 isoniazid
dnaA 1185 c.1185C>G synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 1191 c.1191T>C synonymous_variant 0.25 isoniazid
dnaA 1197 c.1197T>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 1204 c.1204C>T synonymous_variant 0.24 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.21 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.23 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.25 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.26 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.28 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.2 isoniazid
gyrB 6169 c.930C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6209 c.970C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.3 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6400 c.-902C>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6409 c.-893A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6412 c.-890G>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6415 c.-887G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6427 c.-875T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6440 p.Thr401Ala missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6446 p.Ala403Ser missense_variant 0.79 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6451 c.-851A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6460 c.-842G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6469 c.-833T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6484 c.-818A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6490 c.-812T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6502 c.-800T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6508 c.-794A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6523 c.-779G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6526 c.-776T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6535 c.1296C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6547 c.-755T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6550 c.-752A>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6551 c.1312_1314delTTGinsCA frameshift_variant&missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin
gyrA 6565 c.-737G>T upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6571 c.-731T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6580 c.-722C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.23 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6850 c.1611C>A synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6853 c.-449A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6898 c.-404G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.32 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6931 c.1692A>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6934 c.-368A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6970 c.-332C>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7045 c.-257C>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAC frameshift_variant&missense_variant 0.32 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrB 7156 c.1917C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7162 c.-140C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7189 c.-113C>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 7216 c.1977G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7626 c.325C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7685 c.384G>A synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7691 c.390C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7700 c.399G>A synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7703 c.402G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7710 c.409_411delTTGinsCC frameshift_variant&missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7769 c.468C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7841 c.540C>T synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7853 c.552C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8216 c.915G>A synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8219 c.918T>G synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8228 c.927G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.39 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.28 levofloxacin
moxifloxacin
gyrA 8340 c.1039_1041delGCGinsTC frameshift_variant&missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8360 c.1059G>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8392 p.Tyr364Phe missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8402 p.Asp367Glu missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8420 c.1119T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8426 c.1125G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8429 c.1128C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8501 c.1200G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8504 c.1203G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8520 c.1219C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8561 c.1260A>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8579 c.1278C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8762 c.1461G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9056 c.1755C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 9161 c.1860C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9191 c.1890G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9206 c.1905C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9566 c.2265C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13579 c.-21G>A upstream_gene_variant 1.0 isoniazid Uncertain significance
fgd1 491031 c.249C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491076 c.294G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491077 p.Asn99Asp missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491082 c.300T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491133 c.351A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491151 c.369G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491163 c.381G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491250 c.468G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491262 c.480C>A synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491283 p.Asp167Glu missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491289 c.507C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491292 c.510G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491296 p.Val172Ile missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491302 p.Ile174Val missense_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491349 c.567T>C synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491583 c.801G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575629 c.282A>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575632 c.285G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.21 ethionamide
isoniazid Not assoc w R - Interim
mshA 575638 c.291T>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575649 p.Val101Ala missense_variant 0.21 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575662 c.315C>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.29 ethionamide
isoniazid Not assoc w R - Interim
mshA 575701 c.354G>A synonymous_variant 0.29 ethionamide
isoniazid
mshA 575704 c.357T>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.36 ethionamide
isoniazid
mshA 575740 c.393G>A synonymous_variant 0.37 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.35 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.35 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.34 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.33 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.34 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.29 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575830 c.483C>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575845 c.498C>T synonymous_variant 0.31 ethionamide
isoniazid Not assoc w R - Interim
mshA 575864 c.517T>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575884 c.537G>C synonymous_variant 0.24 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.19 ethionamide
isoniazid
ccsA 619507 c.-384A>G upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619519 c.-372C>T upstream_gene_variant 0.71 capreomycin
amikacin
kanamycin
ccsA 619528 c.-363C>G upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619531 c.-360T>C upstream_gene_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 619535 c.-356_-354delCAAinsGCG upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619543 c.-348C>G upstream_gene_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 619552 c.-339A>G upstream_gene_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 619555 c.-336C>G upstream_gene_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 619570 c.-321G>C upstream_gene_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>G upstream_gene_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619668 c.-223_-222delCGinsGC upstream_gene_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 619672 c.-219A>C upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620256 c.366C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>G synonymous_variant 0.2 capreomycin
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620284 c.394_396delGCGinsCC frameshift_variant&missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620310 c.420C>T synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.32 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620424 c.534G>C synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620433 c.543C>G synonymous_variant 0.29 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>G synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620460 c.570T>A synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620461 p.Val191Ile missense_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620481 c.591T>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
Rv0565c 656916 c.555G>A synonymous_variant 0.16 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.24 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.24 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.24 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.24 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.25 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.23 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.22 ethionamide
Rv0565c 657348 c.123A>G synonymous_variant 0.21 ethionamide
Rv0565c 657356 p.Ile39Val missense_variant 0.21 ethionamide
Rv0565c 657359 p.Thr38Ala missense_variant 0.19 ethionamide
Rv0565c 657363 c.108C>G synonymous_variant 0.19 ethionamide
Rv0565c 657372 c.99G>C synonymous_variant 0.21 ethionamide
Rv0565c 657375 c.96C>T synonymous_variant 0.21 ethionamide
Rv0565c 657385 p.Ile29Thr missense_variant 0.22 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 1.0 ethionamide
hadA 731732 c.-198G>A upstream_gene_variant 0.2 isoniazid
hadA 731750 c.-180G>C upstream_gene_variant 0.83 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.17 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.17 isoniazid
hadA 732337 c.408G>A synonymous_variant 0.2 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.23 isoniazid
hadA 732361 c.432C>G synonymous_variant 0.28 isoniazid
hadA 732370 c.441C>G synonymous_variant 0.28 isoniazid
hadA 732373 p.Glu148Asp missense_variant 0.27 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.22 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.28 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.27 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.27 isoniazid
nusG 734360 p.Ala36Val missense_variant 0.2 rifampicin Uncertain significance
nusG 734370 c.117A>G synonymous_variant 0.22 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.23 rifampicin
nusG 734403 c.150C>T synonymous_variant 0.3 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.29 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.34 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.35 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.38 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.4 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.4 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.42 rifampicin
nusG 734481 c.228C>T synonymous_variant 0.44 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.32 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.33 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.34 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.32 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.31 rifampicin
nusG 734607 c.354C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734610 c.357C>G synonymous_variant 0.3 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.31 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.28 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.26 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.25 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.26 rifampicin
nusG 734646 c.393G>C synonymous_variant 0.27 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.27 rifampicin
nusG 734658 c.405A>G synonymous_variant 0.27 rifampicin Not assoc w R
nusG 734661 c.408A>C synonymous_variant 0.26 rifampicin
nusG 734664 c.411T>G synonymous_variant 0.25 rifampicin
nusG 734673 c.420A>G synonymous_variant 0.23 rifampicin
nusG 734679 c.426C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734680 c.427_429delGCCinsAG frameshift_variant&missense_variant 0.2 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.2 rifampicin
nusG 734775 c.522C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734781 c.528A>G synonymous_variant 0.19 rifampicin
nusG 734787 c.534T>C synonymous_variant 0.2 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.19 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.19 rifampicin Uncertain significance
nusG 734814 c.561G>C synonymous_variant 0.26 rifampicin
nusG 734826 c.573A>G synonymous_variant 0.25 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734847 c.594T>C synonymous_variant 0.23 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.22 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.22 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.22 rifampicin
rpoB 760061 p.Tyr85* stop_gained 0.17 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.26 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.31 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.31 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.33 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.29 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.32 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.34 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.32 rifampicin
rpoB 760331 c.525G>T synonymous_variant 0.33 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.35 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.36 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.35 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.3 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760519 p.Thr238Ser missense_variant 0.21 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.21 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.22 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.26 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.27 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.37 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760755 p.His317Asn missense_variant 0.43 rifampicin
rpoB 760763 c.957C>G synonymous_variant 0.43 rifampicin
rpoB 760765 p.Glu320Ala missense_variant 0.43 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.42 rifampicin
rpoB 760796 c.990A>G synonymous_variant 0.41 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.44 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.41 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.42 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.41 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.41 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.41 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.4 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.38 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.41 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.41 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.42 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761096 c.1290G>C synonymous_variant 0.4 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.4 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.38 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.42 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.41 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.45 rifampicin
rpoB 761318 c.1512G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.41 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.37 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761373 p.Val523His missense_variant 0.34 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.34 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.3 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.25 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.24 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.24 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.24 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.24 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.23 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.24 rifampicin
rpoB 761462 c.1656C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761465 c.1659G>C synonymous_variant 0.28 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.31 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.29 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.34 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.42 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.41 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.29 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.23 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.21 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.22 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.23 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.24 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.25 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.27 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.28 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.3 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.32 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.31 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.31 rifampicin
rpoB 761831 c.2025C>A synonymous_variant 0.33 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.33 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.31 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.32 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.33 rifampicin
rpoB 761867 c.2061C>T synonymous_variant 0.37 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.36 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.37 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.32 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.33 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.34 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.34 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761972 c.2166C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.41 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.47 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.47 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.45 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.45 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.46 rifampicin
rpoB 762212 c.2406G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762221 c.2415G>A synonymous_variant 0.44 rifampicin
rpoB 762233 c.2427G>T synonymous_variant 0.45 rifampicin
rpoB 762239 c.2433G>A synonymous_variant 0.45 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.44 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.42 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.42 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762323 c.2517C>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.39 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.37 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.35 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.36 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.35 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.3 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.28 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.32 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.33 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.36 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.27 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.27 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.28 rifampicin
rpoC 762521 c.-849C>G upstream_gene_variant 0.28 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.24 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.23 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.23 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.24 rifampicin
rpoB 762750 p.Leu982Met missense_variant 0.16 rifampicin
rpoB 762785 p.Asp993Glu missense_variant 0.25 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.27 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.28 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.28 rifampicin Uncertain significance
rpoB 762810 p.Ala1002Ser missense_variant 0.28 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.29 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762971 c.3165G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.41 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.52 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.35 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.34 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763202 c.-168A>C upstream_gene_variant 0.24 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.24 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.24 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763227 c.3421C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.2 rifampicin
rpoC 763402 c.33C>A synonymous_variant 0.21 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.21 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.24 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>A synonymous_variant 0.33 rifampicin
rpoC 763486 c.117T>G synonymous_variant 0.33 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.36 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.32 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>A synonymous_variant 0.33 rifampicin
rpoC 763723 c.354G>C synonymous_variant 0.32 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.33 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.34 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.34 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.34 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.34 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.35 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763835 p.Ala156Leu missense_variant 0.33 rifampicin
rpoC 763853 c.484_486delGTCinsAT frameshift_variant&missense_variant 0.35 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.35 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.36 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.37 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.38 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.36 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.35 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.35 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.39 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.36 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.31 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.32 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.35 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.37 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.34 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.33 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.34 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.36 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.31 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.36 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.35 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.38 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.39 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.4 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.42 rifampicin
rpoC 764218 c.849C>T synonymous_variant 0.43 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.39 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.35 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.34 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.34 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764329 c.960C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>T synonymous_variant 0.39 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.41 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.42 rifampicin
rpoC 764419 c.1050C>G synonymous_variant 0.45 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.4 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.4 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.4 rifampicin
rpoC 764455 c.1086G>T synonymous_variant 0.39 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.41 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764506 c.1137C>T synonymous_variant 0.36 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.32 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.35 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.36 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.33 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.38 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.42 rifampicin
rpoC 764719 c.1350G>A synonymous_variant 0.44 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.41 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.38 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.32 rifampicin Not assoc w R
rpoC 765007 c.1637_1638insGC frameshift_variant 0.23 rifampicin
rpoC 765010 c.1641_1643delGAGinsC frameshift_variant&missense_variant 0.24 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.28 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.19 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765371 c.2002C>T synonymous_variant 0.2 rifampicin
rpoC 765379 c.2010G>A synonymous_variant 0.2 rifampicin
rpoC 765383 c.2014_2016delATGinsCT frameshift_variant&missense_variant 0.21 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.25 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.26 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.27 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.3 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.34 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.42 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.41 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.36 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.36 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.38 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.38 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.4 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.33 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.33 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.36 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.34 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.36 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.35 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.35 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.39 rifampicin
rpoC 765883 c.2514C>G synonymous_variant 0.37 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.36 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765898 c.2529C>T synonymous_variant 0.37 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.29 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.22 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.23 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.22 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.22 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.21 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.16 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.18 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.2 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.28 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.3 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.32 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.33 rifampicin
rpoC 766360 c.2991C>T synonymous_variant 0.32 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.33 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.33 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.37 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.37 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.38 rifampicin
rpoC 766393 c.3024C>A synonymous_variant 0.38 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.39 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.41 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.41 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.43 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.37 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.36 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.39 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.41 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.39 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.38 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.37 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.37 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.33 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.32 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.34 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.36 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.41 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.44 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.45 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.4 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.4 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.43 rifampicin
rpoC 766733 c.3364C>T synonymous_variant 0.45 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.45 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.47 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.49 rifampicin
rpoC 766777 c.3408C>T synonymous_variant 0.49 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.47 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.47 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.43 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.42 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.43 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.43 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.47 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.48 rifampicin
rpoC 766981 c.3612T>C synonymous_variant 0.48 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.47 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.45 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.47 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.46 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.43 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.42 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.38 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767265 p.Ala1299Glu missense_variant 0.17 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775937 c.2544G>T synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.19 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.19 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.21 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.21 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.2 streptomycin Uncertain significance
rpsL 781609 p.Ser17Thr missense_variant 0.19 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.25 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.24 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.27 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.29 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.39 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.39 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.41 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.38 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.36 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.36 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.36 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.38 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.39 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.38 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.37 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.37 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.4 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.39 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.37 streptomycin
rpsL 781862 c.303G>A synonymous_variant 0.35 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.33 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.33 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.33 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.35 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.34 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.34 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.35 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.38 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.23 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.26 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.26 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.28 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.32 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.32 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.33 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.35 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.36 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.34 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.34 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.33 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.32 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.31 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.33 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.34 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.35 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.33 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.31 linezolid
rplC 800794 c.-15_-9delAGATTGGinsGAGTT upstream_gene_variant 0.29 linezolid
rplC 800814 c.6A>G synonymous_variant 0.29 linezolid
rplC 800817 c.9A>T synonymous_variant 0.31 linezolid
rplC 800844 c.36T>C synonymous_variant 0.31 linezolid
rplC 800865 c.57A>G synonymous_variant 0.23 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.23 linezolid
rplC 800873 p.Arg22Lys missense_variant 0.2 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.2 linezolid
rplC 800880 c.72A>G synonymous_variant 0.2 linezolid
rplC 800889 c.81C>G synonymous_variant 0.2 linezolid
rplC 800892 c.84G>C synonymous_variant 0.21 linezolid
rplC 800907 c.99C>G synonymous_variant 0.22 linezolid
rplC 800916 c.108A>G synonymous_variant 0.19 linezolid
rplC 801114 c.306C>G synonymous_variant 0.2 linezolid
rplC 801117 c.309G>C synonymous_variant 0.21 linezolid
rplC 801132 c.324T>C synonymous_variant 0.2 linezolid
rplC 801147 c.339T>C synonymous_variant 0.2 linezolid
rplC 801153 c.345G>C synonymous_variant 0.21 linezolid
rplC 801156 c.348T>A synonymous_variant 0.23 linezolid
rplC 801168 c.360C>G synonymous_variant 0.27 linezolid
rplC 801171 c.363A>G synonymous_variant 0.28 linezolid
rplC 801174 c.366T>C synonymous_variant 0.28 linezolid
rplC 801195 c.387G>C synonymous_variant 0.31 linezolid
rplC 801207 c.399C>T synonymous_variant 0.29 linezolid
rplC 801219 c.411C>G synonymous_variant 0.27 linezolid
rplC 801222 c.414T>C synonymous_variant 0.28 linezolid
rplC 801246 c.438C>T synonymous_variant 0.33 linezolid
rplC 801249 c.441T>C synonymous_variant 0.33 linezolid
rplC 801255 c.447C>T synonymous_variant 0.33 linezolid
rplC 801264 c.456C>T synonymous_variant 0.3 linezolid
rplC 801267 c.459A>T synonymous_variant 0.29 linezolid
rplC 801270 c.462T>C synonymous_variant 0.28 linezolid
rplC 801276 c.468G>C synonymous_variant 0.28 linezolid
rplC 801279 c.471G>C synonymous_variant 0.27 linezolid
rplC 801282 c.474G>C synonymous_variant 0.27 linezolid
rplC 801285 c.477G>T synonymous_variant 0.27 linezolid
rplC 801309 c.501C>G synonymous_variant 0.26 linezolid
rplC 801312 c.504G>C synonymous_variant 0.27 linezolid
rplC 801321 c.513C>T synonymous_variant 0.29 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.28 linezolid
rplC 801339 c.531T>C synonymous_variant 0.26 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.26 linezolid
rplC 801348 c.540T>G synonymous_variant 0.28 linezolid
rplC 801357 c.549T>C synonymous_variant 0.28 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.28 linezolid
rplC 801402 c.594T>C synonymous_variant 0.25 linezolid
rplC 801405 c.597T>C synonymous_variant 0.25 linezolid
rplC 801423 c.615G>C synonymous_variant 0.28 linezolid
rplC 801426 c.618C>G synonymous_variant 0.27 linezolid
rplC 801427 p.Met207Val missense_variant 0.3 linezolid
rplC 801438 c.630T>C synonymous_variant 0.3 linezolid
rplC 801442 p.Ile212Val missense_variant 0.32 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303501 c.571C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303521 c.591C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303654 c.724C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303660 p.Val244Thr missense_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.39 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303827 c.897A>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303833 c.903C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303869 c.939T>C synonymous_variant 0.46 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303881 c.951G>A synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.49 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.47 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304001 c.1071C>T synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304085 c.1155C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304090 p.Asp387Ala missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304115 c.1185A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304132 p.Ala401Gly missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304511 c.1581C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304517 c.1587C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304520 c.1590A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304562 c.1632G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>A synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304853 c.1923C>T synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304889 c.1959G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304904 c.1974G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304968 c.2038C>T synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1304991 c.2061G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305014 p.Thr695Ser missense_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>A synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305027 c.2097G>A synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305051 c.2121G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305074 p.Ser715Thr missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305252 c.2322G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305273 c.2343C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305306 c.2376A>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305311 p.Arg794Gln missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
atpE 1460825 c.-220C>T upstream_gene_variant 0.19 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.19 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.21 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.17 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.19 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.21 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.21 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.22 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.22 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.21 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.19 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.22 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474040 n.383G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474043 n.386G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.37 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
fabG1 1673338 c.-102G>A upstream_gene_variant 1.0 ethionamide
isoniazid
inhA 1673523 c.-679G>T upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673542 c.-660C>T upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673547 c.-655T>C upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.3 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.33 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>G upstream_gene_variant 0.32 ethionamide
isoniazid
inhA 1673595 c.-607A>C upstream_gene_variant 0.33 ethionamide
isoniazid
fabG1 1673596 p.Lys53Glu missense_variant 0.33 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1673616 c.-586A>G upstream_gene_variant 0.32 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.32 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.32 ethionamide
isoniazid
fabG1 1673635 p.Asp66Asn missense_variant 0.31 ethionamide
isoniazid
fabG1 1673641 p.Val68Ile missense_variant 0.32 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.3 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.3 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.3 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1673673 c.-529C>T upstream_gene_variant 0.3 ethionamide
isoniazid
inhA 1673679 c.-523T>C upstream_gene_variant 0.33 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673682 c.-520G>C upstream_gene_variant 0.34 ethionamide Uncertain significance
isoniazid Uncertain significance
fabG1 1673710 p.Leu91Ile missense_variant 0.28 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.21 ethionamide
isoniazid
inhA 1673736 c.-466G>A upstream_gene_variant 0.19 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.23 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.27 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.33 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.36 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.35 ethionamide
isoniazid
inhA 1674033 c.-169T>C upstream_gene_variant 0.32 ethionamide
isoniazid
fabG1 1674037 p.Gln200Ala missense_variant 0.29 ethionamide
isoniazid
inhA 1674042 c.-160G>C upstream_gene_variant 0.3 ethionamide
isoniazid Uncertain significance
fabG1 1674049 c.610_612delCAAinsGT frameshift_variant&missense_variant 0.28 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.29 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.3 ethionamide
isoniazid
inhA 1674063 c.-139G>C upstream_gene_variant 0.3 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.29 ethionamide
isoniazid
inhA 1674090 c.-112C>T upstream_gene_variant 0.25 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674699 c.498C>T synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674750 c.549T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674759 c.558G>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674816 c.615T>C synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674832 p.Ala211Thr missense_variant 0.26 ethionamide
isoniazid
inhA 1674838 p.Ala213Ser missense_variant 0.26 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.28 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.26 ethionamide
isoniazid
inhA 1674909 c.708G>A synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674960 c.759C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674967 p.Asp256Asn missense_variant 0.16 ethionamide
isoniazid
rpsA 1833634 c.93G>A synonymous_variant 0.25 pyrazinamide
rpsA 1833649 c.108C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.4 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.42 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.42 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.43 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.42 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.38 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.45 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.44 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.46 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.24 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.28 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.32 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.36 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.39 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>G synonymous_variant 0.47 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.48 pyrazinamide
rpsA 1834375 c.834G>A synonymous_variant 0.46 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834465 c.924T>A synonymous_variant 0.38 pyrazinamide
rpsA 1834468 c.927A>C synonymous_variant 0.4 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.45 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834546 c.1005T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.42 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.46 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.46 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.42 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.39 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.34 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.31 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.25 pyrazinamide
tsnR 1853360 c.-246G>A upstream_gene_variant 0.35 linezolid
tsnR 1853361 c.-245T>C upstream_gene_variant 0.35 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.35 linezolid
tsnR 1853375 c.-231G>C upstream_gene_variant 0.35 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.37 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.36 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.36 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.33 linezolid
tsnR 1853429 c.-177G>T upstream_gene_variant 0.31 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.3 linezolid
tsnR 1853444 c.-162C>T upstream_gene_variant 0.25 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.25 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.19 linezolid
tsnR 1853565 c.-41G>A upstream_gene_variant 1.0 linezolid Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1918356 c.417C>G synonymous_variant 0.18 capreomycin
tlyA 1918377 c.438T>G synonymous_variant 0.21 capreomycin
tlyA 1918379 p.Arg147Gln missense_variant 0.2 capreomycin
tlyA 1918382 p.Val148Ala missense_variant 0.19 capreomycin
tlyA 1918389 c.450G>C synonymous_variant 0.2 capreomycin
tlyA 1918392 c.453A>C synonymous_variant 0.2 capreomycin
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
ndh 2101918 c.1125G>A synonymous_variant 0.17 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2101921 c.1122G>A synonymous_variant 0.83 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101939 c.1104A>T synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2102635 c.408C>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102638 c.405A>C synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102644 c.399A>G synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102671 c.372T>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2103112 c.-70G>T upstream_gene_variant 1.0 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289949 c.-708A>G upstream_gene_variant 0.19 pyrazinamide
pncA 2289991 c.-750G>C upstream_gene_variant 0.19 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.19 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.21 pyrazinamide
pncA 2290024 c.-783C>G upstream_gene_variant 0.21 pyrazinamide
pncA 2290030 c.-791_-789delAATinsCC upstream_gene_variant 0.21 pyrazinamide
pncA 2290033 c.-794_-792delGCCinsAG upstream_gene_variant 0.21 pyrazinamide
pncA 2290042 c.-801T>C upstream_gene_variant 0.22 pyrazinamide
pncA 2290045 c.-804G>A upstream_gene_variant 0.22 pyrazinamide
pncA 2290062 c.-821G>A upstream_gene_variant 0.79 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.31 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.3 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.25 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.2 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.17 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518459 c.345T>C synonymous_variant 0.19 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.2 isoniazid
kasA 2518474 c.360G>A synonymous_variant 0.21 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.25 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.27 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.34 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.35 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.36 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.36 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.36 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.38 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.38 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.36 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.37 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.38 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.38 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.4 isoniazid
kasA 2518618 c.504G>T synonymous_variant 0.41 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.42 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.4 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.37 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.41 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.43 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.43 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.4 isoniazid
kasA 2518699 c.585C>T synonymous_variant 0.39 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.38 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.4 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.4 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.4 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.47 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.46 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.46 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.46 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.44 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.42 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.41 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.41 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.43 isoniazid
kasA 2518846 c.732G>C synonymous_variant 0.42 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.34 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.33 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.29 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.28 isoniazid
kasA 2518906 c.792A>T synonymous_variant 0.26 isoniazid
kasA 2518907 c.793T>C synonymous_variant 0.25 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.25 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.25 isoniazid
kasA 2518927 c.813C>G synonymous_variant 0.24 isoniazid
kasA 2518930 c.816G>C synonymous_variant 0.24 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.23 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.23 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.24 isoniazid
kasA 2518951 c.837G>C synonymous_variant 0.24 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.24 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.24 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.19 isoniazid
kasA 2519044 c.930G>C synonymous_variant 0.19 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.23 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.25 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.25 isoniazid
kasA 2519092 c.978C>T synonymous_variant 0.26 isoniazid
kasA 2519095 c.981C>G synonymous_variant 0.28 isoniazid
kasA 2519104 c.990T>C synonymous_variant 0.26 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.25 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.25 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.3 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.31 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.34 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.36 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.35 isoniazid
kasA 2519196 p.Thr361Ser missense_variant 0.32 isoniazid
kasA 2519221 c.1107G>C synonymous_variant 0.35 isoniazid
kasA 2519230 c.1116C>T synonymous_variant 0.3 isoniazid
kasA 2519236 c.1122G>A synonymous_variant 0.29 isoniazid
kasA 2519239 c.1125A>C synonymous_variant 0.28 isoniazid
kasA 2519242 c.1128C>T synonymous_variant 0.26 isoniazid
kasA 2519245 c.1131T>C synonymous_variant 0.25 isoniazid
kasA 2519260 c.1146T>G synonymous_variant 0.2 isoniazid
kasA 2519263 c.1149C>T synonymous_variant 0.2 isoniazid
kasA 2519266 c.1152C>T synonymous_variant 0.18 isoniazid
kasA 2519269 c.1155C>T synonymous_variant 0.19 isoniazid
kasA 2519281 c.1167G>T synonymous_variant 0.18 isoniazid
folC 2746308 p.Arg431Ser missense_variant 0.19 para-aminosalicylic_acid
folC 2746329 c.1270C>A synonymous_variant 0.18 para-aminosalicylic_acid
folC 2746353 p.Ala416Ser missense_variant 0.19 para-aminosalicylic_acid
folC 2746354 c.1245G>A synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.25 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.25 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.21 para-aminosalicylic_acid
folC 2747401 c.198G>C synonymous_variant 0.19 para-aminosalicylic_acid
Rv2477c 2782828 c.1215T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782841 p.Thr401Asn missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782846 p.Arg399Lys missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.26 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>T synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.43 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783248 c.795G>A synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783287 c.756C>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783521 c.522G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783668 c.375G>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783725 c.318C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783728 c.315G>A synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783737 c.306C>G synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783853 c.190C>T synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.42 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784366 c.-324G>C upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784372 c.-330G>A upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784375 c.-333T>C upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784381 c.-339T>C upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784390 c.-348G>C upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.93 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784399 c.-357G>A upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784411 c.-369G>A upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2681 2997060 p.Asn108Asp missense_variant 0.18 capreomycin
Rv2752c 3064664 p.Lys510Gln missense_variant 0.94 ethambutol Uncertain significance
moxifloxacin
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065430 c.762A>T synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065451 c.741G>A synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065457 c.735A>C synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065460 c.732G>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065463 c.729T>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065466 c.726G>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065481 c.711T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065484 c.708G>A synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065487 c.705T>G synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065490 c.702A>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065493 c.699G>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065496 c.696G>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065499 c.693A>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065502 p.Asp230Glu missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065508 c.684T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065511 c.681G>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065517 c.675C>G synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065520 c.672G>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065532 c.660A>G synonymous_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065553 c.639A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065946 p.Gly82Ala missense_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065957 c.235T>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065979 c.213T>C synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.3 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065997 c.195C>G synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066003 c.189C>T synonymous_variant 0.29 ethambutol
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin
isoniazid
Rv2752c 3066018 c.174T>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>G synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.23 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066437 c.-246G>A upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066498 c.-307C>A upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066713 c.-522C>T upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066734 c.-543G>A upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066748 c.-558_-557delCAinsAT upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066795 c.-604G>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066804 c.-613G>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066810 c.-619G>A upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066822 c.-631T>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066831 c.-640G>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066839 c.-648A>G upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067277 c.669C>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067281 p.Val222Ala missense_variant 0.21 para-aminosalicylic_acid
thyX 3067284 p.Ala221Asp missense_variant 0.21 para-aminosalicylic_acid
thyX 3067286 c.660C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067289 c.657C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067292 c.654G>A synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067295 c.651C>T synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067304 c.642A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067322 c.624C>T synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067343 c.603C>T synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067427 c.519G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067676 c.270C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067693 p.Ile85Leu missense_variant 0.29 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067730 c.216G>A synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.28 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.29 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067811 c.135G>A synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067853 c.93C>T synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.26 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.23 para-aminosalicylic_acid
thyX 3067949 c.-4C>T upstream_gene_variant 0.92 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.19 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.26 para-aminosalicylic_acid
thyA 3073902 c.570C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073958 c.514C>T synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.38 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3074013 c.459C>T synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.36 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.35 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3074121 p.Asp117Glu missense_variant 0.34 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074134 p.Ser113Thr missense_variant 0.32 para-aminosalicylic_acid
thyA 3074147 p.Ile109Val missense_variant 0.23 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAG frameshift_variant&missense_variant 0.21 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074184 c.288A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074199 c.273G>A synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.21 para-aminosalicylic_acid
thyA 3074214 p.Asp86Glu missense_variant 0.21 para-aminosalicylic_acid
thyA 3074244 c.228A>G synonymous_variant 0.19 para-aminosalicylic_acid
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
ald 3087172 p.Glu118Ala missense_variant 0.99 cycloserine
ald 3087184 c.368_373delCCGACG disruptive_inframe_deletion 0.99 cycloserine
Rv3236c 3612237 p.Ala294Ser missense_variant 1.0 pyrazinamide
lpqB 3623456 c.1455T>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3623465 c.1446G>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3623468 c.1443T>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623471 c.1440C>T synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3623484 p.Phe476Tyr missense_variant 0.24 bedaquiline
rifampicin
lpqB 3623489 c.1422C>T synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623492 c.1419T>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3623512 p.Gly467Ser missense_variant 0.29 bedaquiline
rifampicin
lpqB 3623528 c.1383G>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3623531 c.1380T>C synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3623555 c.1354_1356delGGGinsAC frameshift_variant&missense_variant 0.25 bedaquiline
rifampicin Uncertain significance
lpqB 3623561 c.1350T>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3623573 c.1338T>G synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3623576 c.1335T>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3623580 p.Asn444Thr missense_variant 0.19 bedaquiline
rifampicin
lpqB 3623627 c.1284T>C synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3623630 c.1281G>C synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624014 c.897T>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624026 c.884_885delAGinsTGAC frameshift_variant&missense_variant 0.23 bedaquiline
rifampicin Uncertain significance
lpqB 3624030 c.879_880delTG frameshift_variant 0.23 bedaquiline
rifampicin Uncertain significance
lpqB 3624037 c.874A>C synonymous_variant 0.25 bedaquiline
rifampicin
lpqB 3624041 p.Glu290Asp missense_variant 0.27 bedaquiline
rifampicin
lpqB 3624050 c.861C>G synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624077 c.834G>C synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624082 c.829A>C synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3624092 c.817_819delAGGinsCC frameshift_variant&missense_variant 0.33 bedaquiline
rifampicin Uncertain significance
lpqB 3624100 c.811T>C synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3624101 c.810C>G synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624119 c.792C>T synonymous_variant 0.37 bedaquiline
rifampicin
lpqB 3624124 p.Leu263Val missense_variant 0.34 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624166 p.Met249Leu missense_variant 0.28 bedaquiline
rifampicin
lpqB 3624167 c.744C>T synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624173 c.738A>C synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624179 c.732C>T synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624185 c.726C>T synonymous_variant 0.27 bedaquiline
rifampicin
lpqB 3624200 c.711A>G synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624204 p.Ser236Asn missense_variant 0.21 bedaquiline
rifampicin
lpqB 3624209 c.702A>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624350 c.561G>T synonymous_variant 0.96 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624632 c.279G>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624646 c.265T>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624650 c.261G>A synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624656 c.255C>T synonymous_variant 0.3 bedaquiline
rifampicin
lpqB 3624673 p.Ala80Ser missense_variant 0.31 bedaquiline
rifampicin
lpqB 3624674 c.237C>T synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.32 bedaquiline
rifampicin Uncertain significance
lpqB 3624698 c.213G>A synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624701 c.210T>C synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.33 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.34 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.37 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.34 bedaquiline
rifampicin Uncertain significance
lpqB 3624770 c.141T>C synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3624776 c.135T>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624783 p.Ser43Thr missense_variant 0.21 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625069 c.-159T>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625087 c.1525_1527delGCCinsTG frameshift_variant&missense_variant 0.27 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625093 p.Glu507Asp missense_variant 0.26 bedaquiline
rifampicin
lpqB 3625117 c.-207T>G upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625134 c.-224T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625135 c.1479A>G synonymous_variant 0.29 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625138 c.-228C>G upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625141 c.-231T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.34 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.36 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625189 c.-279A>C upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625195 c.-285A>G upstream_gene_variant 0.41 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3625206 p.Ser470Ala missense_variant 0.39 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625243 c.-333T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625246 c.-336G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625255 c.-345T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
lpqB 3625258 c.-348G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.4 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3625301 p.Ala438Gly missense_variant 0.38 bedaquiline
rifampicin
mtrB 3625313 p.Arg434Lys missense_variant 0.31 bedaquiline
rifampicin
lpqB 3625315 c.-405G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3625321 c.1293A>G synonymous_variant 0.28 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625327 c.-417A>G upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625345 c.-435T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625351 c.1263T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625357 c.-447T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625549 c.-639G>A upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.26 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.28 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.29 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625648 c.-738T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.24 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3625753 c.859_861delGCCinsAT frameshift_variant&missense_variant 0.35 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625762 c.852A>T synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625777 c.-867C>G upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3625804 c.808_810delAGGinsCC frameshift_variant&missense_variant 0.37 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625807 c.807C>G synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625879 c.-969G>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626750 c.-137T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.24 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627125 c.-512C>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627196 c.-583C>T upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627209 c.-596G>A upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.33 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3627343 p.Thr3Ser missense_variant 0.24 bedaquiline
rifampicin
fbiB 3641876 c.342C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3641879 c.345G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3641880 p.Ser116Asp missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3641888 c.354A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3641900 c.366G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3641906 c.372T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3641909 c.375T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3641914 p.Ala127Gly missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3641918 c.384T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3641924 c.390A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3641927 c.393C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3641928 c.394T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3641935 p.Ala134Val missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3641938 p.Gly135Ala missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3641957 c.423C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3641961 p.Thr143Glu missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3641969 c.435C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642581 c.1047A>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3642587 p.Met351Ile missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642593 c.1059G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiB 3642602 c.1068A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642605 c.1071A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiB 3642609 c.1075_1076delAGinsTC synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3642620 c.1086T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiB 3642659 c.1125C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiB 3642662 c.1128C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiB 3642668 c.1134A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiB 3642677 c.1143A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642680 c.1146A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642682 p.Ala383Gly missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiB 3642719 c.1185T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiB 3642731 c.1197C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3642758 c.1224C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
alr 3840932 c.489C>T synonymous_variant 0.92 cycloserine
alr 3840959 c.462G>C synonymous_variant 0.18 cycloserine
alr 3841017 p.Leu135Gln missense_variant 0.17 cycloserine
alr 3841033 p.Val130Ile missense_variant 0.19 cycloserine
alr 3841039 p.Val128Met missense_variant 0.19 cycloserine
alr 3841069 p.Ile118Phe missense_variant 0.2 cycloserine
rpoA 3877515 c.993G>C synonymous_variant 0.21 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.29 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.33 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.43 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.43 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877665 c.843C>T synonymous_variant 0.37 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.37 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.37 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.43 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.43 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.41 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.42 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.42 rifampicin
rpoA 3877896 c.612G>T synonymous_variant 0.4 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.39 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.36 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.36 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.36 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.33 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.31 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.3 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>A synonymous_variant 0.29 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.3 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.31 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.29 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.27 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.28 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.3 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.3 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.31 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.3 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.27 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.26 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.25 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.25 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.24 rifampicin Uncertain significance
rpoA 3878148 c.360C>T synonymous_variant 0.24 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878166 c.342C>G synonymous_variant 0.28 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.31 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.32 rifampicin
rpoA 3878205 c.303T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878232 c.276G>C synonymous_variant 0.34 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.32 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.26 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.29 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.27 rifampicin
rpoA 3878361 c.147G>C synonymous_variant 0.26 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.25 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.25 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.27 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.3 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.28 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.29 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.29 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.3 rifampicin
rpoA 3878400 c.108T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.29 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.27 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.24 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.22 rifampicin
rpoA 3878458 p.Asn17Ser missense_variant 0.21 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.2 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.23 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.24 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.24 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.29 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.34 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.34 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.36 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.35 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.37 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.3 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.3 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.37 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878884 c.-377C>T upstream_gene_variant 0.39 rifampicin
rpoA 3878890 c.-383C>G upstream_gene_variant 0.4 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.41 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.44 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.47 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.48 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.46 rifampicin Uncertain significance
rpoA 3878971 c.-464C>T upstream_gene_variant 0.45 rifampicin
rpoA 3878976 c.-469A>G upstream_gene_variant 0.47 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.46 rifampicin
rpoA 3878989 c.-482G>C upstream_gene_variant 0.45 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.45 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.42 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.45 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.46 rifampicin
rpoA 3879033 c.-526C>T upstream_gene_variant 0.44 rifampicin
rpoA 3879034 c.-527G>A upstream_gene_variant 0.44 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.38 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.36 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.35 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.37 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.37 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.35 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.34 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.32 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.27 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.23 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.26 rifampicin
ddn 3986645 c.-199G>A upstream_gene_variant 0.22 delamanid
pretomanid
ddn 3986987 c.144G>T synonymous_variant 1.0 delamanid Not assoc w R - Interim
pretomanid
ddn 3987180 p.Asp113Asn missense_variant 1.0 delamanid Uncertain significance
pretomanid
clpC1 4038271 p.Pro812Ala missense_variant 0.31 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.32 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.34 pyrazinamide
clpC1 4038308 c.2397G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038314 c.2391T>A synonymous_variant 0.36 pyrazinamide
clpC1 4038329 c.2376G>A synonymous_variant 0.35 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.34 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038374 c.2331C>T synonymous_variant 0.37 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.4 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.36 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.36 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.39 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.4 pyrazinamide
clpC1 4038458 c.2247G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038461 c.2244G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038488 c.2217C>G synonymous_variant 0.45 pyrazinamide
clpC1 4038498 p.Ser736Ala missense_variant 0.43 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.36 pyrazinamide
clpC1 4038533 p.Arg724Lys missense_variant 0.36 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.37 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.41 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.38 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038650 c.2055C>T synonymous_variant 0.35 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.34 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.34 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.34 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.38 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.36 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.37 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.39 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.39 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.37 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038977 c.1728G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038992 c.1713C>T synonymous_variant 0.39 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.37 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039193 c.1512C>A synonymous_variant 0.31 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.25 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.26 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.24 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.32 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.32 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.32 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039466 c.1239T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.37 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.37 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>T synonymous_variant 0.4 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.42 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.4 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.42 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039823 c.882T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.32 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039976 c.729G>A synonymous_variant 0.36 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.38 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.31 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040141 c.564C>T synonymous_variant 0.29 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.22 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040207 c.498T>G synonymous_variant 0.21 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.21 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.21 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.21 pyrazinamide
clpC1 4040234 c.471C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.24 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.25 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.28 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040345 c.360C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.22 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.25 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.22 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040824 c.-120C>T upstream_gene_variant 1.0 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.17 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.2 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.24 pyrazinamide
panD 4044742 c.-461T>C upstream_gene_variant 0.23 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.23 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.24 pyrazinamide
panD 4044758 c.-477C>T upstream_gene_variant 0.23 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.22 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.22 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.22 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.23 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.23 pyrazinamide
panD 4044822 c.-542_-541delGGinsAA upstream_gene_variant 0.23 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.23 pyrazinamide
panD 4044848 c.-567T>A upstream_gene_variant 0.22 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.21 pyrazinamide
panD 4044965 c.-684T>C upstream_gene_variant 0.22 pyrazinamide
panD 4044977 c.-696T>C upstream_gene_variant 0.21 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.2 pyrazinamide
panD 4044983 c.-702G>C upstream_gene_variant 0.2 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.2 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138409 c.1347G>T synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138418 c.1338T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138424 c.1332T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138429 c.1327T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138451 c.1305T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138460 c.1296C>T synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138472 c.1284G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138478 c.1278T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138481 c.1275G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138490 c.1266G>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138495 p.Gln421Glu missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138496 c.1260G>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138502 c.1254T>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138514 c.1242A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138517 p.Glu413Ala missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138523 c.1233C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138550 c.1206C>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.25 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138682 c.1074C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138694 p.Pro354Asp missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138712 c.1044G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138730 c.1026C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138733 c.1023C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139131 p.Glu209Lys missense_variant 0.85 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Uncertain significance
glpK 4139165 c.591A>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139177 c.579T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139186 c.570G>T synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139195 c.561G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139198 c.558C>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139228 c.528G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139231 c.525A>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139243 c.513A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139253 p.Asn168Arg missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139265 p.Ala164Glu missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139273 c.483A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139276 c.480T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139282 c.474T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139285 c.471A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139290 c.466C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139297 c.459G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239843 c.-20A>C upstream_gene_variant 1.0 ethambutol Not assoc w R - Interim
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240677 p.Gly272Ala missense_variant 0.2 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.2 ethambutol
embC 4240688 p.Leu276Met missense_variant 0.23 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.25 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.3 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.29 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.33 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.31 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.3 ethambutol
embC 4240831 c.969T>C synonymous_variant 0.3 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.26 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.24 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.24 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.24 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.24 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.21 ethambutol
embC 4240886 p.Ile342Val missense_variant 0.21 ethambutol
embC 4240897 c.1035C>A synonymous_variant 0.22 ethambutol
embC 4240898 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.22 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.26 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.26 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.26 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.25 ethambutol
embC 4240945 c.1083T>G synonymous_variant 0.21 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.2 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.21 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.22 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.26 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.27 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.34 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.37 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.4 ethambutol
embC 4241129 c.1267C>T synonymous_variant 0.4 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.39 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.35 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.34 ethambutol
embC 4241179 c.1317G>C synonymous_variant 0.34 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.26 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4241230 c.1368A>G synonymous_variant 0.18 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.24 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.23 ethambutol
embC 4241464 c.1602C>G synonymous_variant 0.27 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.26 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.27 ethambutol
embC 4241485 c.1623G>T synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4241488 c.1626G>C synonymous_variant 0.26 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.27 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.26 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.26 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.27 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.28 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>A synonymous_variant 0.27 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.24 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.24 ethambutol
embC 4241548 c.1686T>C synonymous_variant 0.24 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.23 ethambutol
embC 4241560 c.1698C>G synonymous_variant 0.25 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.24 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.23 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.21 ethambutol
embC 4241648 c.1786_1788delTTGinsCC frameshift_variant&missense_variant 0.18 ethambutol
embC 4241657 p.Ser599Pro missense_variant 0.2 ethambutol
embC 4241665 c.1803G>C synonymous_variant 0.23 ethambutol
embC 4241671 c.1809T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4241691 p.Gly610Ala missense_variant 0.22 ethambutol Uncertain significance
embC 4241694 p.Ala611Val missense_variant 0.24 ethambutol
embC 4241698 c.1836G>T synonymous_variant 0.23 ethambutol
embC 4241704 c.1842C>G synonymous_variant 0.22 ethambutol
embC 4241708 c.1846C>A synonymous_variant 0.23 ethambutol
embC 4241713 c.1851G>C synonymous_variant 0.22 ethambutol
embC 4241719 c.1857G>C synonymous_variant 0.23 ethambutol
embC 4241727 p.Phe622Tyr missense_variant 0.23 ethambutol
embC 4241734 c.1872C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4241741 p.Val627Leu missense_variant 0.2 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.97 ethambutol Not assoc w R
embA 4242739 c.-494C>G upstream_gene_variant 0.22 ethambutol
embA 4242742 c.-491C>G upstream_gene_variant 0.23 ethambutol
embA 4242748 c.-485A>G upstream_gene_variant 0.22 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.22 ethambutol
embC 4242756 p.Ile965Thr missense_variant 0.22 ethambutol
embC 4242762 p.Arg967Gln missense_variant 0.21 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.21 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.25 ethambutol
embC 4242791 c.2929_2931delGCAinsTC frameshift_variant&missense_variant 0.29 ethambutol
embA 4242796 c.-437G>C upstream_gene_variant 0.29 ethambutol
embA 4242799 c.-434T>C upstream_gene_variant 0.28 ethambutol
embA 4242820 c.-413G>C upstream_gene_variant 0.32 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.31 ethambutol
embA 4242832 c.-401A>C upstream_gene_variant 0.33 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.32 ethambutol
embA 4242844 c.-389A>G upstream_gene_variant 0.29 ethambutol
embA 4242847 c.-386C>A upstream_gene_variant 0.28 ethambutol
embA 4242862 c.-371A>G upstream_gene_variant 0.22 ethambutol
embC 4242863 p.Tyr1001Asn missense_variant 0.23 ethambutol
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244576 c.1344G>C synonymous_variant 0.19 ethambutol
embA 4244632 p.Thr467Ile missense_variant 0.17 ethambutol
embA 4244635 p.Val468Ala missense_variant 0.82 ethambutol Not assoc w R - Interim
embA 4245101 c.1869G>C synonymous_variant 0.21 ethambutol
embA 4245131 c.1899G>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embA 4245137 c.1905T>C synonymous_variant 0.34 ethambutol
embA 4245147 c.1915_1917delCCCinsTG frameshift_variant&missense_variant 0.65 ethambutol Uncertain significance
embA 4245152 c.1920C>G synonymous_variant 0.36 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.36 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.39 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.39 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.36 ethambutol
embA 4245206 c.1974A>G synonymous_variant 0.35 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.35 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.35 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.31 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.34 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.34 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embA 4245282 p.Ile684Val missense_variant 0.25 ethambutol
embA 4245285 c.2053T>C synonymous_variant 0.22 ethambutol
embA 4245290 c.2058C>G synonymous_variant 0.22 ethambutol
embA 4245293 c.2061T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embA 4245296 c.2064G>C synonymous_variant 0.23 ethambutol
embA 4245299 c.2067A>G synonymous_variant 0.23 ethambutol
embA 4245315 p.Val695Thr missense_variant 0.21 ethambutol
embA 4245328 p.Ala699Val missense_variant 0.18 ethambutol
embA 4245341 c.2109C>G synonymous_variant 0.19 ethambutol
embA 4245345 p.Met705Leu missense_variant 0.2 ethambutol
embA 4245348 p.Ala706Thr missense_variant 0.2 ethambutol
embA 4245355 p.Ala708Gly missense_variant 0.21 ethambutol
embA 4245368 c.2136T>C synonymous_variant 0.2 ethambutol
embB 4245767 c.-747G>A upstream_gene_variant 0.18 ethambutol
embA 4245771 p.Asn847Ser missense_variant 0.18 ethambutol Uncertain significance
embA 4245785 c.2553G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4245797 c.-717C>G upstream_gene_variant 0.23 ethambutol
embB 4247437 c.924A>C synonymous_variant 0.2 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.18 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.19 ethambutol
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248115 c.1602C>T synonymous_variant 0.22 ethambutol Not assoc w R
embB 4248118 c.1605T>C synonymous_variant 0.23 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.25 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.25 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.25 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.25 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4248160 c.1647C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.33 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.35 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.35 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.36 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.36 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embB 4248304 c.1791G>C synonymous_variant 0.3 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.25 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.27 ethambutol
embB 4248322 c.1809G>T synonymous_variant 0.28 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.28 ethambutol
embB 4248346 c.1833G>C synonymous_variant 0.27 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.25 ethambutol
embB 4248355 c.1842A>C synonymous_variant 0.25 ethambutol
embB 4248358 c.1845C>A synonymous_variant 0.25 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4248362 p.Ser617Ala missense_variant 0.26 ethambutol
embB 4248394 c.1881G>A synonymous_variant 0.28 ethambutol
embB 4248400 c.1887G>T synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4248407 p.Leu632Val missense_variant 0.25 ethambutol
embB 4248412 c.1899C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248416 c.1903_1905delCTGinsGA frameshift_variant&missense_variant 0.23 ethambutol
embB 4248419 c.1906C>T synonymous_variant 0.23 ethambutol
embB 4248424 c.1911G>C synonymous_variant 0.22 ethambutol
embB 4248425 c.1912T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4248432 p.Trp640Phe missense_variant 0.21 ethambutol
embB 4249348 c.2835G>C synonymous_variant 0.2 ethambutol
embB 4249351 c.2838C>G synonymous_variant 0.2 ethambutol
embB 4249354 c.2841G>A synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4249369 c.2856T>C synonymous_variant 0.24 ethambutol
embB 4249375 c.2862G>C synonymous_variant 0.26 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.32 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.33 ethambutol Uncertain significance
embB 4249432 c.2919A>G synonymous_variant 0.33 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.27 ethambutol
embB 4249445 c.2932_2934delGTGinsAC frameshift_variant&missense_variant 0.27 ethambutol
embB 4249456 c.2943G>C synonymous_variant 0.32 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.3 ethambutol
embB 4249486 c.2973T>A synonymous_variant 0.3 ethambutol
embB 4249495 c.2982C>T synonymous_variant 0.71 ethambutol Not assoc w R - Interim
embB 4249498 c.2985G>C synonymous_variant 0.29 ethambutol
embB 4249520 p.Ala1003Thr missense_variant 0.29 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.25 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.25 ethambutol Uncertain significance
embB 4249558 c.3045A>C synonymous_variant 0.19 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.18 ethambutol
embB 4249581 p.Leu1023Gln missense_variant 0.17 ethambutol
aftB 4267574 c.1263G>A synonymous_variant 0.23 ethambutol
aftB 4267580 c.1257G>T synonymous_variant 0.22 ethambutol
aftB 4267595 c.1242C>T synonymous_variant 0.24 ethambutol
aftB 4267604 c.1233C>G synonymous_variant 0.19 ethambutol
aftB 4268096 c.741C>G synonymous_variant 0.2 ethambutol
aftB 4268099 c.738G>C synonymous_variant 0.2 ethambutol
aftB 4268102 c.735C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
aftB 4268105 c.732T>C synonymous_variant 0.2 ethambutol
aftB 4268117 c.720G>C synonymous_variant 0.23 ethambutol
aftB 4268123 c.712_714delAGTinsGC frameshift_variant&synonymous_variant 0.23 ethambutol Uncertain significance
aftB 4268126 c.711G>C synonymous_variant 0.23 ethambutol
aftB 4268129 c.708T>G synonymous_variant 0.23 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.23 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.24 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.25 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.25 ethambutol
aftB 4268178 c.658_659insGC frameshift_variant 0.25 ethambutol Uncertain significance
aftB 4268181 c.654_655delAT frameshift_variant 0.26 ethambutol Uncertain significance
aftB 4268194 p.Leu215Val missense_variant 0.23 ethambutol
aftB 4268205 p.Val211Ala missense_variant 0.19 ethambutol
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326914 p.Ala187Glu missense_variant 1.0 ethionamide Uncertain significance
ethA 4327103 p.Gly124Asp missense_variant 1.0 ethionamide Uncertain significance
ethR 4328190 p.Glu214Asp missense_variant 1.0 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407946 p.Leu86Pro missense_variant 1.0 streptomycin Uncertain significance