TB-Profiler result

Run: SRR1792478
Summary

Run ID: SRR1792478

Sample name:

Date: 2024-03-26T17:07:19.138670

Number of reads: 1439644

Percentage reads mapped: 53.19

Median coverage: 54.0

Strain: La1.7.1

Spoligotype:

Drug-resistance: HR-TB

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.7 M.bovis None 0.98
La1.7.1 M.bovis None 1.0
La1 M.bovis None 0.94
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser140Asn Uncertain significance Mutation from literature
ethambutol
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.601_603delATGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303531 c.601_603delATGinsCC frameshift_variant&missense_variant 0.17 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155693 p.Ser140Asn missense_variant 0.24 isoniazid Uncertain significance Mutation from literature
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
dnaA 624 c.624C>T synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 633 c.633T>G synonymous_variant 0.21 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 651 c.651G>T synonymous_variant 0.21 isoniazid
dnaA 652 c.652_654delCTAinsTG frameshift_variant&stop_gained 0.21 isoniazid Uncertain significance
dnaA 660 c.660G>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.21 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>C synonymous_variant 0.23 isoniazid
dnaA 682 c.682T>C synonymous_variant 0.23 isoniazid
dnaA 687 c.687C>T synonymous_variant 0.22 isoniazid
dnaA 690 c.690G>C synonymous_variant 0.21 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 699 c.699G>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.27 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.27 isoniazid
dnaA 714 c.714C>G synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 741 c.741T>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 748 c.748_750delCTCinsTG frameshift_variant&missense_variant 0.26 isoniazid Uncertain significance
dnaA 767 p.Val256Ala missense_variant 0.26 isoniazid
dnaA 769 p.Ala257Ser missense_variant 0.27 isoniazid Uncertain significance
dnaA 792 c.792C>T synonymous_variant 0.25 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.24 isoniazid Uncertain significance
dnaA 805 c.805T>C synonymous_variant 0.31 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.29 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.28 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.26 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.27 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.25 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.26 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.25 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.26 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.27 isoniazid
dnaA 888 c.888C>G synonymous_variant 0.26 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.29 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.27 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.25 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.23 isoniazid
dnaA 954 c.954G>T synonymous_variant 0.16 isoniazid
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6214 c.975G>A synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6217 c.978G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6242 p.Arg335Asn missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6259 p.Asp340Glu missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6266 p.Pro343Ala missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6280 c.1041T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6406 c.1167C>T synonymous_variant 0.97 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 0.96 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 6700 c.-602T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6766 c.-536G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6794 p.Ile519Leu missense_variant 0.27 levofloxacin
moxifloxacin
gyrB 6798 p.Gly520Ala missense_variant 0.27 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6802 c.1563G>A synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.32 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6820 c.-482C>A upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6896 p.Arg553Lys missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 6905 p.Ile556Val missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7451 c.150C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7670 c.369A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCC frameshift_variant&missense_variant 0.31 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7700 c.399G>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7703 c.402G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7706 c.405C>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7778 c.477G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7796 c.495G>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7821 c.520C>T synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7832 c.531G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7847 c.546G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7868 p.Ile189Met missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7871 c.570G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7880 c.579C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7886 c.585T>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8126 c.825G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8129 c.828T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8192 c.891C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8201 c.900C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.37 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8318 c.1017C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8321 c.1020C>T synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.5 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8354 c.1053G>T synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 8357 c.1056G>C synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.52 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8390 c.1089C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.43 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8400 p.Asp367Asn missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8408 c.1107A>G synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 8411 c.1110C>G synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8526 c.1225C>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8540 c.1239C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>T synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8556 p.Ala419Gln missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8562 c.1261C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8568 p.Glu423Gln missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8573 c.1272G>A synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8900 c.1599G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8906 c.1605C>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8915 c.1614A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9020 c.1719G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9051 c.1750T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9065 c.1764C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9092 c.1791C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCC frameshift_variant&missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9104 c.1803C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9113 c.1812C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9188 p.Asn629Lys missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9197 c.1896G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9206 c.1905C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9208 p.Lys636Arg missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9217 p.Asp639Ala missense_variant 0.8 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9230 c.1929T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9260 c.1959G>C synonymous_variant 0.3 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9267 p.Asn656Gly missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9329 c.2028C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9332 p.Asn677Lys missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9345 c.2044_2046delAGGinsCC frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9351 c.2050_2052delTCGinsGA frameshift_variant&missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9369 c.2068C>T synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 9395 c.2094G>C synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9419 c.2118T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9421 p.Ile707Thr missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 9429 p.Arg710Ala missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 9449 c.2148C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9453 c.2153_2155delGTG disruptive_inframe_deletion 0.23 levofloxacin
moxifloxacin
gyrA 9459 c.2158_2159delGGinsCCCGA missense_variant&conservative_inframe_insertion 0.23 levofloxacin
moxifloxacin
gyrA 9464 c.2163C>A synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9466 p.Tyr722Phe missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 9476 c.2175G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9483 c.2182_2184delTCAinsGC frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 9488 c.2187G>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9503 c.2202T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9515 p.Glu738Asp missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9518 c.2217A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9527 c.2226A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9539 c.2238C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
ccsA 620238 c.348G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620247 p.Leu119Phe missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620250 c.360C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620253 c.363G>T synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620256 c.366C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620257 p.Ile123Val missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620269 p.Val127Ile missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620275 c.385C>T synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620296 p.Pro136Ala missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620311 p.Leu141Val missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620319 c.429C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620326 c.436C>T synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620343 c.453G>T synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620352 c.462C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.17 ethionamide
Rv0565c 657725 c.-255G>C upstream_gene_variant 0.21 ethionamide
Rv0565c 657732 c.-263_-262delAGinsGA upstream_gene_variant 0.2 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.2 ethionamide
nusG 734475 c.222T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.2 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.17 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.28 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760271 c.465C>G synonymous_variant 0.33 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.27 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.27 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 0.29 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.3 rifampicin
rpoB 760331 c.525G>T synonymous_variant 0.3 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.31 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.32 rifampicin
rpoB 760359 p.Ile185Arg missense_variant 0.34 rifampicin
rpoB 760368 p.Ser188Thr missense_variant 0.38 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.41 rifampicin
rpoB 760407 c.601_603delAGCinsGG frameshift_variant&missense_variant 0.41 rifampicin
rpoB 760418 c.612G>A synonymous_variant 0.42 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.43 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760493 c.687C>G synonymous_variant 0.42 rifampicin
rpoB 760521 p.Ser239Ala missense_variant 0.38 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.34 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.34 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.33 rifampicin
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.34 rifampicin
rpoB 760634 c.828T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.29 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760674 c.868T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760965 c.1159_1161delATGinsCC frameshift_variant&missense_variant 0.18 rifampicin
rpoB 760970 c.1164G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.24 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761003 c.1197C>G synonymous_variant 0.24 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>A synonymous_variant 0.34 rifampicin
rpoB 761054 c.1248G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.39 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.38 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761217 c.1411_1413delCCGinsTC frameshift_variant&missense_variant 0.31 rifampicin
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.3 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>C synonymous_variant 0.35 rifampicin
rpoB 761261 c.1455G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761285 c.1479G>A synonymous_variant 0.27 rifampicin
rpoB 761289 p.Ser495Ala missense_variant 0.25 rifampicin
rpoB 761292 p.Val496Thr missense_variant 0.25 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761336 c.1530C>T synonymous_variant 0.26 rifampicin
rpoB 761346 p.Val514Asn missense_variant 0.19 rifampicin
rpoB 761349 c.1543_1545delGACinsAG frameshift_variant&missense_variant 0.18 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.19 rifampicin
rpoB 761357 c.1551G>C synonymous_variant 0.2 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761373 p.Val523His missense_variant 0.22 rifampicin
rpoB 761399 c.1593C>T synonymous_variant 0.18 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.18 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.19 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.2 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.18 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.18 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.18 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.18 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.19 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.19 rifampicin
rpoB 761702 c.1896C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761984 c.2178G>A synonymous_variant 0.31 rifampicin
rpoB 761999 c.2193G>C synonymous_variant 0.3 rifampicin
rpoB 762014 c.2208C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.43 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.44 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.45 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.45 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.44 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762251 c.2445G>C synonymous_variant 0.4 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.37 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.36 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.34 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762335 c.2529C>T synonymous_variant 0.36 rifampicin
rpoB 762338 c.2532T>C synonymous_variant 0.35 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.33 rifampicin
rpoB 762350 c.2544C>G synonymous_variant 0.32 rifampicin
rpoB 762353 c.2547C>T synonymous_variant 0.35 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.36 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.34 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.3 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.29 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.29 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.27 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.29 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762510 p.Ala902Pro missense_variant 0.26 rifampicin Uncertain significance
rpoC 762521 c.-849C>G upstream_gene_variant 0.24 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.21 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.19 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.2 rifampicin
rpoB 762537 c.2731_2733delTTGinsCC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.16 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762833 c.3027C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762839 c.-531G>A upstream_gene_variant 0.26 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.45 rifampicin Uncertain significance
rpoC 762908 c.-462G>A upstream_gene_variant 0.46 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.51 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.31 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.27 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.23 rifampicin
rpoC 763179 c.-191C>T upstream_gene_variant 0.24 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.3 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.49 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.49 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>A synonymous_variant 0.51 rifampicin
rpoC 763696 c.327T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.52 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.52 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.5 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.52 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.5 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763774 c.405G>C synonymous_variant 0.45 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.5 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.5 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.51 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.47 rifampicin
rpoC 763816 c.447C>G synonymous_variant 0.46 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.44 rifampicin
rpoC 763836 p.Ala156Val missense_variant 0.41 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.41 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.43 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.43 rifampicin
rpoC 763870 c.501C>T synonymous_variant 0.43 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.43 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.41 rifampicin
rpoC 763879 c.510A>C synonymous_variant 0.41 rifampicin
rpoC 763885 c.516C>G synonymous_variant 0.41 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.4 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.4 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763912 c.543G>C synonymous_variant 0.31 rifampicin
rpoC 763913 p.Ala182Lys missense_variant 0.31 rifampicin
rpoC 763921 c.552G>C synonymous_variant 0.31 rifampicin
rpoC 763926 p.Ala186Glu missense_variant 0.31 rifampicin
rpoC 763940 p.Ala191Ser missense_variant 0.31 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.34 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.35 rifampicin Uncertain significance
rpoC 763960 c.591T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763966 c.597C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.38 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.36 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.37 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.34 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.3 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.28 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.3 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.27 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.28 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.24 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.21 rifampicin
rpoC 764084 p.Asn239Val missense_variant 0.21 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764126 p.Thr253Gln missense_variant 0.29 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.3 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.32 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.33 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.31 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764209 c.840C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>T synonymous_variant 0.32 rifampicin
rpoC 764227 c.858G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764239 c.870T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>T synonymous_variant 0.35 rifampicin
rpoC 764254 c.885G>C synonymous_variant 0.35 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.4 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.41 rifampicin
rpoC 764269 c.900G>T synonymous_variant 0.41 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.33 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.32 rifampicin
rpoC 764344 c.975C>G synonymous_variant 0.3 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>T synonymous_variant 0.31 rifampicin
rpoC 764377 c.1008C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.25 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764392 c.1023C>T synonymous_variant 0.3 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.33 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.33 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.34 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.38 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.4 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.39 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.47 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764698 c.1329G>T synonymous_variant 0.37 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>A synonymous_variant 0.35 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764749 c.1380G>C synonymous_variant 0.3 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.35 rifampicin
rpoC 764803 c.1434C>G synonymous_variant 0.34 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.31 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764844 p.Ala492Gly missense_variant 0.25 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764923 c.1554A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.23 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.23 rifampicin
rpoC 764956 c.1587T>C synonymous_variant 0.23 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764983 c.1614T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>A synonymous_variant 0.24 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>T synonymous_variant 0.3 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.3 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.29 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.26 rifampicin
rpoC 765122 c.1753C>T synonymous_variant 0.21 rifampicin
rpoC 765126 p.Tyr586Phe missense_variant 0.2 rifampicin
rpoC 765404 c.2035C>T synonymous_variant 0.16 rifampicin
rpoC 765419 p.Val684Ile missense_variant 0.19 rifampicin Uncertain significance
rpoC 765425 p.Lys686Gln missense_variant 0.2 rifampicin
rpoC 765439 c.2070G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.23 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.26 rifampicin
rpoC 765469 c.2100G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765481 c.2112C>T synonymous_variant 0.28 rifampicin
rpoC 765496 c.2127C>T synonymous_variant 0.27 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.26 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.26 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.27 rifampicin
rpoC 765577 c.2208G>C synonymous_variant 0.29 rifampicin
rpoC 765578 c.2209_2211delCTGinsAC frameshift_variant&missense_variant 0.29 rifampicin
rpoC 765590 p.Arg741Asn missense_variant 0.28 rifampicin
rpoC 765596 p.Lys743Gln missense_variant 0.27 rifampicin
rpoC 765612 p.His748Arg missense_variant 0.17 rifampicin
rpoC 765644 p.Gln759Lys missense_variant 0.16 rifampicin
rpoC 765648 p.Phe760Tyr missense_variant 0.18 rifampicin
rpoC 765655 c.2286T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765684 p.Glu772Gly missense_variant 0.23 rifampicin
rpoC 765687 p.Ala773Glu missense_variant 0.23 rifampicin Uncertain significance
rpoC 765694 c.2325G>C synonymous_variant 0.23 rifampicin
rpoC 765695 p.Glu776Lys missense_variant 0.23 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765704 p.Lys779Gln missense_variant 0.23 rifampicin
rpoC 765707 c.2338_2340delGAAinsCG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 765712 c.2343C>G synonymous_variant 0.24 rifampicin
rpoC 765718 p.Asp783Glu missense_variant 0.24 rifampicin Uncertain significance
rpoC 765727 c.2358T>C synonymous_variant 0.24 rifampicin
rpoC 765728 p.Gln787Glu missense_variant 0.24 rifampicin
rpoC 765733 c.2364G>T synonymous_variant 0.25 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.28 rifampicin
rpoC 765752 c.2383_2385delGACinsCG frameshift_variant&missense_variant 0.28 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.31 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.32 rifampicin
rpoC 765790 c.2421C>G synonymous_variant 0.3 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.3 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.3 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.3 rifampicin
rpoC 765814 c.2445A>C synonymous_variant 0.28 rifampicin
rpoC 765823 c.2454C>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>A synonymous_variant 0.3 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.34 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.32 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765904 c.2535C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.23 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765961 c.2592G>T synonymous_variant 0.19 rifampicin
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.19 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765973 c.2604C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766003 c.2634G>C synonymous_variant 0.17 rifampicin
rpoC 766009 c.2640G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.17 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.17 rifampicin
rpoC 766027 c.2658G>T synonymous_variant 0.17 rifampicin
rpoC 766035 p.His889Pro missense_variant 0.16 rifampicin
rpoC 766042 c.2673C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766043 p.Gln892Glu missense_variant 0.15 rifampicin
rpoC 766363 c.2994G>T synonymous_variant 0.17 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.15 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.18 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.18 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.22 rifampicin
rpoC 766423 c.3054T>C synonymous_variant 0.3 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.3 rifampicin
rpoC 766429 c.3060C>G synonymous_variant 0.31 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.32 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.24 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.22 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.19 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.21 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.23 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.22 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.19 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.23 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.28 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.29 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.29 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.41 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>G synonymous_variant 0.47 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.48 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766876 c.3507C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 766883 p.Ser1172Ala missense_variant 0.48 rifampicin Uncertain significance
rpoC 766894 c.3525T>C synonymous_variant 0.47 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.47 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.48 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.48 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.48 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.48 rifampicin
rpoC 766920 p.Ala1184Gly missense_variant 0.49 rifampicin
rpoC 766931 c.3562_3564delGCAinsAC frameshift_variant&missense_variant 0.46 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766951 c.3582G>C synonymous_variant 0.44 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>T synonymous_variant 0.47 rifampicin
rpoC 766981 c.3612T>C synonymous_variant 0.48 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.31 rifampicin
rpoC 767110 c.3741T>C synonymous_variant 0.3 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.21 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 0.2 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.19 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767227 c.3858G>C synonymous_variant 0.18 rifampicin
rpoC 767230 c.3861G>T synonymous_variant 0.18 rifampicin
rpoC 767233 c.3864T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775865 c.2616T>C synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775881 p.Asn867Arg missense_variant 0.2 clofazimine
bedaquiline
mmpL5 775883 c.2596_2598delATCinsCG frameshift_variant&missense_variant 0.21 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775909 p.Leu858Phe missense_variant 0.18 clofazimine
bedaquiline
mmpL5 775910 c.2571G>C synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 775913 c.2566_2568delGCCinsTA frameshift_variant&missense_variant 0.2 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775916 c.2565T>G synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775922 c.2559G>T synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775925 c.2556G>C synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.29 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.32 streptomycin
rpsL 781649 c.90T>G synonymous_variant 0.35 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.36 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.42 streptomycin
rpsL 781670 c.111G>C synonymous_variant 0.48 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.54 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>G synonymous_variant 0.54 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.53 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.53 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.54 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.53 streptomycin
rpsL 781754 c.195G>T synonymous_variant 0.53 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.52 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.51 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.53 streptomycin Not assoc w R - Interim
rpsL 781769 c.210G>A synonymous_variant 0.5 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.47 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.48 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.49 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.47 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.48 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.46 streptomycin Not assoc w R - Interim
rpsL 781859 c.300T>G synonymous_variant 0.48 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.42 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.41 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.41 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.43 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.42 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.44 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.43 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.42 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.41 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.37 streptomycin Uncertain significance
rplC 800643 c.-166_-164delCGCinsAG upstream_gene_variant 0.19 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.2 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.23 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.24 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.22 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.22 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800744 c.-65G>A upstream_gene_variant 0.18 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.18 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.16 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303539 c.609G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303551 c.621G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303578 c.648G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303581 c.651G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304016 c.1086C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304820 c.1890G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304868 c.1938G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304872 c.1942_1944delAGCinsTCG synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304877 c.1947T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304880 c.1950C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304887 c.1957C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304901 c.1971C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304904 c.1974G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304913 c.1983G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304931 c.2001C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304934 c.2004C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304946 c.2016G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304967 c.2037G>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304970 c.2040G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304988 c.2058G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
sigE 1364691 c.279T>C synonymous_variant 0.17 pyrazinamide
sigE 1364694 c.282G>C synonymous_variant 0.18 pyrazinamide
sigE 1364709 c.297T>C synonymous_variant 0.22 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.22 pyrazinamide
sigE 1364716 c.304_306delCTCinsTG frameshift_variant&missense_variant 0.23 pyrazinamide Uncertain significance
sigE 1364751 c.339C>G synonymous_variant 0.28 pyrazinamide
sigE 1364760 c.348C>G synonymous_variant 0.29 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.29 pyrazinamide
sigE 1364767 c.355_357delAGGinsCC frameshift_variant&missense_variant 0.31 pyrazinamide Uncertain significance
sigE 1364781 c.369G>C synonymous_variant 0.36 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.34 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.35 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.35 pyrazinamide
sigE 1364805 c.393C>G synonymous_variant 0.36 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.38 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.38 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.45 pyrazinamide
sigE 1364860 c.448_450delCGCinsAG frameshift_variant&missense_variant 0.43 pyrazinamide Uncertain significance
sigE 1364865 c.453G>T synonymous_variant 0.44 pyrazinamide
sigE 1364867 p.Ala152Gly missense_variant 0.44 pyrazinamide
sigE 1364877 c.465G>A synonymous_variant 0.46 pyrazinamide
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.49 pyrazinamide Uncertain significance
sigE 1364905 c.493C>A synonymous_variant 0.45 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.28 pyrazinamide
sigE 1364922 c.510G>A synonymous_variant 0.28 pyrazinamide
sigE 1364931 c.519C>G synonymous_variant 0.22 pyrazinamide
sigE 1364949 c.537C>T synonymous_variant 0.19 pyrazinamide
sigE 1364950 c.538_540delGCAinsTG frameshift_variant&stop_gained 0.19 pyrazinamide Uncertain significance
sigE 1364955 c.543G>C synonymous_variant 0.19 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
sigE 1364979 c.567C>G synonymous_variant 0.18 pyrazinamide
sigE 1364980 c.568T>C synonymous_variant 0.18 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.19 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.17 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.16 pyrazinamide
sigE 1365027 c.615C>T synonymous_variant 0.17 pyrazinamide
sigE 1365033 c.621G>A synonymous_variant 0.18 pyrazinamide
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471926 n.81C>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472023 n.178_189delGGACCACGGGATinsTTCCTTGCTGGTC non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195delTinsGC non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472043 n.198T>G non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472048 n.203T>G non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472325 n.480G>A non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472453 n.608G>A non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472459 n.614C>T non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsGGT non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1473791 n.134A>G non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1473811 n.154C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473814 n.157A>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1473828 n.171G>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473830 n.173T>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474287 n.630_631insTC non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474294 n.637_649delCCTCTCCGGAGGAinsGGG non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474373 n.717dupT non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474376 n.719T>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474412 n.756_768delACCCACACGCGCA non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474428 n.771C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474431 n.774G>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474434 n.778_779insAGGGG non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474437 n.781_782delAA non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTCTAAG non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475202 n.1545G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475221 n.1564C>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475289 n.1632G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475296 n.1639G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475366 n.1709G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475375 n.1718G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475377 n.1721delA non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475380 n.1724delG non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475383 n.1726_1727insCC non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475387 n.1730C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475395 n.1738T>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475398 n.1741C>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475407 n.1750C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476077 n.2420T>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>C non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476119 n.2462G>A non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>A non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1476616 n.2959A>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476664 n.3007T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476665 n.3008T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476691 n.3034T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
inhA 1674489 c.288G>T synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674491 p.Phe97Tyr missense_variant 0.19 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674513 c.312C>G synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674543 c.342G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674550 c.349_351delTCCinsGA frameshift_variant&missense_variant 0.22 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674579 c.378G>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674585 c.384T>G synonymous_variant 0.22 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674589 p.Met130Leu missense_variant 0.25 ethionamide
isoniazid
inhA 1674600 c.399G>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.26 ethionamide
isoniazid
inhA 1674619 p.Pro140Lys missense_variant 0.21 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674627 c.426T>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.2 ethionamide
isoniazid
inhA 1674658 c.457C>A synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.16 ethionamide
isoniazid
rpsA 1833589 c.48A>C synonymous_variant 0.18 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.18 pyrazinamide
rpsA 1833616 c.75A>C synonymous_variant 0.22 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.22 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833634 c.93G>A synonymous_variant 0.22 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.26 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.29 pyrazinamide
rpsA 1833685 c.144G>T synonymous_variant 0.31 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.36 pyrazinamide
rpsA 1833712 c.171C>T synonymous_variant 0.36 pyrazinamide
rpsA 1833715 c.174G>A synonymous_variant 0.38 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833733 c.192C>T synonymous_variant 0.4 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.4 pyrazinamide
rpsA 1833739 c.198C>A synonymous_variant 0.39 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.39 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.4 pyrazinamide
rpsA 1833778 c.237C>T synonymous_variant 0.41 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.41 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.4 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.44 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.45 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.47 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.47 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.49 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.49 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.48 pyrazinamide
rpsA 1833901 c.360G>A synonymous_variant 0.5 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.48 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.48 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833979 c.438T>G synonymous_variant 0.46 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.43 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.41 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.42 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834090 c.549G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.28 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.25 pyrazinamide Uncertain significance
rpsA 1834162 c.621A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.25 pyrazinamide Uncertain significance
rpsA 1834172 p.Ile211Val missense_variant 0.25 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>T synonymous_variant 0.29 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834195 c.654G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834258 c.717G>A synonymous_variant 0.32 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834288 c.747C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834297 c.756C>A synonymous_variant 0.35 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834315 c.774C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834318 c.777C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.4 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.46 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.48 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.46 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.49 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.5 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.5 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834522 c.981C>T synonymous_variant 0.52 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834573 c.1032G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834579 c.1038C>G synonymous_variant 0.48 pyrazinamide
rpsA 1834600 c.1059G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.51 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834612 c.1071G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834624 c.1083G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.46 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.44 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.49 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.35 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.31 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834776 p.Ala412Asp missense_variant 0.28 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834798 c.1257C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834811 c.1270C>A synonymous_variant 0.22 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 0.98 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2064996 c.-268G>T upstream_gene_variant 0.15 streptomycin
kanamycin
capreomycin
amikacin
ndh 2103173 c.-132delG upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2155676 c.436C>A synonymous_variant 0.23 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.24 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.26 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.26 isoniazid
katG 2155722 c.390G>T synonymous_variant 0.23 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.22 isoniazid
katG 2155735 p.Met126Ala missense_variant 0.22 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.23 isoniazid
katG 2155748 p.Ala122Thr missense_variant 0.21 isoniazid Uncertain significance
katG 2155752 c.360C>T synonymous_variant 0.21 isoniazid
katG 2155765 p.His116Phe missense_variant 0.19 isoniazid
katG 2155782 c.330C>A synonymous_variant 0.21 isoniazid
katG 2155785 c.327T>C synonymous_variant 0.21 isoniazid
katG 2155796 p.Ala106Thr missense_variant 0.16 isoniazid
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168319 p.Thr765Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.2 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
Rv2477c 2782927 c.1116A>G synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.859_861delCGCinsAG frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783194 c.849A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783206 c.837G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783218 c.825C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783239 c.804G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783242 p.Thr267Gln missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783386 c.657G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783413 c.630G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783425 p.Pro206Lys missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783432 c.610_611delAGinsTC synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783434 c.609C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783449 c.594C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783456 p.Gln196Leu missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783568 p.Asn159His missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2681 2997325 p.Ala196Val missense_variant 1.0 capreomycin Uncertain significance
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623730 p.Ser394Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624350 c.561G>T synonymous_variant 0.96 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624593 c.318G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624710 c.201G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625602 c.-692T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625609 c.-699C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625623 p.Thr331Ala missense_variant 0.33 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625627 p.Asp329Glu missense_variant 0.33 bedaquiline
rifampicin
mtrB 3625633 p.Asp327Glu missense_variant 0.33 bedaquiline
rifampicin
mtrB 3625637 p.Ala326Asp missense_variant 0.34 bedaquiline
rifampicin
mtrB 3625648 c.964_966delTATinsCC frameshift_variant&missense_variant 0.33 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625656 c.958T>C synonymous_variant 0.33 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3625708 c.906C>T synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625720 c.894G>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625723 c.-813C>T upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.35 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>T synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 p.Ser283Gln missense_variant 0.32 bedaquiline
rifampicin
lpqB 3625801 c.-891G>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3625804 c.808_810delAGGinsCC frameshift_variant&missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625807 c.807C>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626699 c.651C>T synonymous_variant 0.18 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626708 c.-95G>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626711 p.Thr213Gln missense_variant 0.17 bedaquiline
rifampicin
mtrB 3626723 c.-110C>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3626749 c.601C>T synonymous_variant 0.28 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626753 c.-140G>A upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626773 c.-160C>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCT frameshift_variant&missense_variant 0.32 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626816 c.534G>A synonymous_variant 0.4 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3626846 c.504G>A synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626879 c.-266G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626894 c.-281C>T upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3626906 c.442_444delAACinsCG frameshift_variant&missense_variant 0.46 bedaquiline
rifampicin
mtrB 3626909 c.-296C>A upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626924 c.-311G>T upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.45 bedaquiline
rifampicin
mtrB 3626942 c.-329A>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626945 c.-332C>T upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3626969 c.381C>T synonymous_variant 0.48 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626972 c.-359A>G upstream_gene_variant 0.56 bedaquiline
rifampicin
mtrA 3626978 p.Asp124Glu missense_variant 0.62 bedaquiline
rifampicin Uncertain significance
mtrB 3626999 c.-386G>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627005 c.-392G>T upstream_gene_variant 0.58 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.6 bedaquiline
rifampicin
mtrB 3627023 c.-410C>G upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrB 3627032 c.-419G>C upstream_gene_variant 0.59 bedaquiline
rifampicin
mtrA 3627041 c.307_309delATCinsGG frameshift_variant&missense_variant 0.58 bedaquiline
rifampicin
mtrB 3627059 c.-446G>C upstream_gene_variant 0.55 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627071 c.-458G>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.47 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627110 c.-497G>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627140 c.-527G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627143 c.-530G>T upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.42 bedaquiline
rifampicin
mtrB 3627191 c.-578G>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3627196 c.-583C>T upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3627218 c.-605G>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627227 c.-614T>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627233 c.-620T>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627251 c.-638G>C upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627263 c.-650C>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrA 3627269 c.81G>T synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627272 c.-659G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627277 c.73C>T synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627284 c.-671C>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627287 c.-674C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
fbiB 3642478 p.Asp315Ala missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
alr 3840214 p.Arg403Cys missense_variant 1.0 cycloserine
rpoA 3877587 c.921A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.29 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.28 rifampicin
rpoA 3877671 c.837C>G synonymous_variant 0.28 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.31 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877701 c.807G>T synonymous_variant 0.4 rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.38 rifampicin
rpoA 3877740 c.768G>C synonymous_variant 0.38 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>T synonymous_variant 0.38 rifampicin
rpoA 3877749 c.759C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>A synonymous_variant 0.44 rifampicin
rpoA 3877770 c.738A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877803 c.705G>C synonymous_variant 0.48 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.42 rifampicin
rpoA 3877878 c.630G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>A synonymous_variant 0.38 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877898 p.Pro204Ala missense_variant 0.38 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.38 rifampicin
rpoA 3877905 c.603A>C synonymous_variant 0.38 rifampicin
rpoA 3877908 p.Asn200Ser missense_variant 0.38 rifampicin
rpoA 3877923 c.585C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>C synonymous_variant 0.46 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.48 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.46 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.45 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.45 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.44 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.45 rifampicin
rpoA 3878046 c.462T>G synonymous_variant 0.42 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.41 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.42 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.38 rifampicin
rpoA 3878064 c.444G>C synonymous_variant 0.38 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.39 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.39 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.41 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.39 rifampicin
rpoA 3878142 p.Gly122Glu missense_variant 0.41 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.46 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>T synonymous_variant 0.49 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.49 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.46 rifampicin Uncertain significance
rpoA 3878202 c.306G>T synonymous_variant 0.42 rifampicin
rpoA 3878205 c.303T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878214 c.294C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878256 c.252G>C synonymous_variant 0.47 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.47 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.44 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 0.43 rifampicin
rpoA 3878307 c.201C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.36 rifampicin
rpoA 3878349 c.159C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878358 c.150C>G synonymous_variant 0.34 rifampicin
rpoA 3878361 c.147G>A synonymous_variant 0.35 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.36 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.34 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878394 c.114G>T synonymous_variant 0.33 rifampicin
rpoA 3878406 c.102G>C synonymous_variant 0.33 rifampicin
rpoA 3878415 c.93C>G synonymous_variant 0.32 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.32 rifampicin
rpoA 3878432 c.76C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878436 c.72A>G synonymous_variant 0.3 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.3 rifampicin
rpoA 3878451 c.57C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878454 c.54A>C synonymous_variant 0.22 rifampicin
rpoA 3878460 p.Asp16Glu missense_variant 0.23 rifampicin
rpoA 3878465 p.Thr15Ala missense_variant 0.24 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.23 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.21 rifampicin
ddn 3986616 c.-228_-226delAGCinsGCA upstream_gene_variant 0.28 delamanid
pretomanid
ddn 3986630 c.-214C>G upstream_gene_variant 0.26 delamanid
pretomanid
ddn 3986633 c.-211C>G upstream_gene_variant 0.22 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.21 delamanid
pretomanid
ddn 3986646 c.-198_-196delCTCinsTG upstream_gene_variant 0.19 delamanid
pretomanid
ddn 3986651 c.-193G>A upstream_gene_variant 0.2 delamanid
pretomanid
ddn 3986661 c.-183C>A upstream_gene_variant 0.15 delamanid
pretomanid
clpC1 4038347 c.2358G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038386 c.2317_2319delTTGinsCA frameshift_variant&missense_variant 0.18 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038395 c.2310C>A synonymous_variant 0.18 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038410 c.2295C>T synonymous_variant 0.25 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.3 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.28 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.28 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.29 pyrazinamide
clpC1 4038474 p.Ser744Ala missense_variant 0.27 pyrazinamide
clpC1 4038485 c.2220delCinsAAAAG frameshift_variant&synonymous_variant 0.3 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.32 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.33 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4038587 c.2118C>G synonymous_variant 0.36 pyrazinamide
clpC1 4038593 c.2112C>T synonymous_variant 0.36 pyrazinamide
clpC1 4038602 c.2103G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.34 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.33 pyrazinamide
clpC1 4038647 c.2058T>G synonymous_variant 0.33 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.28 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.28 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038665 c.2040C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038668 c.2037G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038677 c.2026_2028delCCGinsGT frameshift_variant&missense_variant 0.28 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038704 c.2001T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.33 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>C synonymous_variant 0.41 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.4 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.43 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.43 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.44 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.42 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.44 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.45 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.46 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039094 c.1611C>A synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039097 c.1608G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 0.37 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.42 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039163 c.1540_1542delCTGinsAC frameshift_variant&missense_variant 0.38 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.37 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039193 c.1512C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.39 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039223 c.1482C>T synonymous_variant 0.42 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.43 pyrazinamide
clpC1 4039295 c.1410A>T synonymous_variant 0.43 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.43 pyrazinamide
clpC1 4039319 c.1384_1386delGCTinsAC frameshift_variant&missense_variant 0.42 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.42 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.4 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.42 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.44 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039408 c.1297C>A synonymous_variant 0.44 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.44 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.43 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.47 pyrazinamide
clpC1 4039451 c.1254G>A synonymous_variant 0.48 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.48 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039472 c.1233G>T synonymous_variant 0.5 pyrazinamide
clpC1 4039480 c.1225C>A synonymous_variant 0.47 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.46 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.46 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039694 c.1011G>T synonymous_variant 0.48 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.51 pyrazinamide
clpC1 4039756 c.949C>T synonymous_variant 0.5 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.51 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039790 c.915C>T synonymous_variant 0.54 pyrazinamide
clpC1 4039802 c.903G>C synonymous_variant 0.56 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.58 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.6 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.59 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.64 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.61 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.55 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039913 c.792C>T synonymous_variant 0.54 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.44 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.36 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039964 c.741C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040000 c.705C>T synonymous_variant 0.31 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040021 c.684A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.31 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040051 c.654C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040063 c.642G>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040069 c.636G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.24 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040138 c.567G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040141 c.564C>T synonymous_variant 0.23 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040180 c.525C>T synonymous_variant 0.19 pyrazinamide
clpC1 4040195 c.510G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040243 c.462C>A synonymous_variant 0.42 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.4 pyrazinamide
clpC1 4040257 p.Ala150Thr missense_variant 0.4 pyrazinamide
clpC1 4040270 c.435C>T synonymous_variant 0.39 pyrazinamide
clpC1 4040273 c.432T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.39 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.4 pyrazinamide
clpC1 4040326 c.379C>T synonymous_variant 0.31 pyrazinamide
clpC1 4040327 c.378G>A synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040333 c.372G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040336 c.369G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>G synonymous_variant 0.22 pyrazinamide
clpC1 4040429 c.274_276delTTGinsCT frameshift_variant&missense_variant 0.23 pyrazinamide
clpC1 4040437 c.268C>T synonymous_variant 0.26 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040462 c.243C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.27 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.34 pyrazinamide
clpC1 4040495 c.210C>T synonymous_variant 0.36 pyrazinamide
clpC1 4040498 c.207G>A synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>G synonymous_variant 0.38 pyrazinamide
clpC1 4040539 c.166C>T synonymous_variant 0.3 pyrazinamide
clpC1 4040540 c.165G>T synonymous_variant 0.29 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040549 c.154_156delTTGinsCT frameshift_variant&missense_variant 0.3 pyrazinamide
clpC1 4040552 c.153G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.35 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040588 c.117T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040594 c.111G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCT frameshift_variant&missense_variant 0.27 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.27 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.27 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.19 pyrazinamide
clpC1 4040648 c.57G>A synonymous_variant 0.18 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138696 p.Pro354Ser missense_variant 0.25 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138700 c.1056G>A synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1030_1032delGCAinsTG frameshift_variant&missense_variant 0.36 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138727 c.1029C>T synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138747 c.1009C>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138775 c.981C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4246551 p.Asn13Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248085 c.1572T>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248168 p.Thr552Ile missense_variant 0.15 ethambutol
embB 4248170 p.Ala553Ser missense_variant 0.15 ethambutol
embB 4248173 p.Val554Met missense_variant 0.16 ethambutol
embB 4248182 p.Met557Leu missense_variant 0.16 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248223 c.1710G>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248242 p.Val577Ile missense_variant 0.16 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.18 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.17 ethambutol
embB 4249538 c.3025_3027delATCinsGG frameshift_variant&missense_variant 0.16 ethambutol
aftB 4267858 p.Ile327Val missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 0.98 streptomycin Not assoc w R